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@article{LBFGS,
  title={On the limited memory BFGS method for large scale optimization},
  author={Liu, Dong C and Nocedal, Jorge},
  journal={Mathematical programming},
  volume={45},
  number={1-3},
  pages={503--528},
  year={1989},
  publisher={Springer}
}

@article{FIREMinimizer,
  title={Structural relaxation made simple},
  author={Bitzek, Erik and Koskinen, Pekka and G{\"a}hler, Franz and Moseler, Michael and Gumbsch, Peter},
  journal={Physical review letters},
  volume={97},
  number={17},
  pages={170201},
  year={2006},
  publisher={APS}
}
@article{LeimkuhlerMatthews2016,
  title={Efficient molecular dynamics using geodesic integration and solvent--solute splitting},
  author={Leimkuhler, Benedict and Matthews, Charles},
  journal={Proc. R. Soc. A},
  volume={472},
  number={2189},
  pages={20160138},
  year={2016},
  publisher={The Royal Society}
}
@article{Tan2017:SAMS,
  title={Optimally adjusted mixture sampling and locally weighted histogram analysis},
  author={Tan, Zhiqiang},
  journal={Journal of Computational and Graphical Statistics},
  volume={26},
  number={1},
  pages={54--65},
  year={2017},
  publisher={Taylor \& Francis}
}

@article{Berendsen1987,
   author = {Berendsen, H. J. C. and Grigera, J. R. and Straatsma, T. P.},
   title = {The missing term in effective pair potentials},
   journal = {Journal of Physical Chemistry},
   volume = {91},
   pages = {6269-6271},
   year = {1987},
   type = {Journal Article}
}

@article{Boresch2003,
   author = {Boresch, S. and Tettinger, F. and Leitgeb, M. and Karplus, M.},
   title = {Absolute Binding Free Energies:  A Quantitative Approach for Their Calculation},
   journal = {Journal of Physical Chemistry B},
   volume = {107},
   pages = {9535},
   year = {2003},
   type = {Journal Article}
}

@article{Essmann1995,
   author = {Essmann, Ulrich and Perera, Lalith and Berkowitz, Max L. and Darden, Tom and Lee, Hsing and Pedersen, Lee G.},
   title = {A smooth particle mesh {Ewald} method},
   journal = {Journal of Chemical Physics},
   volume = {103},
   number = {19},
   pages = {8577-8593},
   year = {1995},
   type = {Journal Article}
}

@article{Hawkins1995,
   author = {Hawkins, Gregory D. and Cramer, Christopher J. and Truhlar, Donald G.},
   title = {Pairwise solute descreening of solute charges from a dielectric medium},
   journal = {Chemical Physics Letters},
   volume = {246},
   number = {1-2},
   pages = {122-129},
   year = {1995},
   type = {Journal Article}
}

@article{Horn2004,
   author = {Horn, Hans W. and Swope, William C. and Pitera, Jed W. and Madura, Jeffry D. and Dick, Thomas J. and Hura, Greg L. and Head-Gordon, Teresa},
   title = {Development of an improved four-site water model for biomolecular simulations: {TIP4P-Ew}},
   journal = {Journal of Chemical Physics},
   volume = {120},
   pages = {9665-9678},
   year = {2004},
   type = {Journal Article}
}

@article{Jorgensen1983,
   author = {Jorgensen, William L. and Chandrasekhar, Jayaraman and Madura, Jeffry D. and Impey, Roger W. and Klein, Michael L.},
   title = {Comparison of simple potential functions for simulating liquid water},
   journal = {Journal of Chemical Physics},
   volume = {79},
   pages = {926-935},
   year = {1983},
   type = {Journal Article}
}

@article{Lamoureux2006,
   author = {Lamoureux, Guillaume and Harder, Edward and Vorobyov, Igor V. and Roux, Benoit and MacKerell Jr., Alexander D.},
   title = {A polarizable model of water for molecular dynamics simulations of biomolecules},
   journal = {Chemical Physics Letters},
   volume = {418},
   number = {1-3},
   pages = {245-249},
   year = {2006},
   type = {Journal Article}
}

@article{Mahoney2000,
   author = {Mahoney, Michael W. and Jorgensen, William L.},
   title = {A five-site model for liquid water and the reproduction of the density anomaly by rigid, nonpolarizable potential functions},
   journal = {Journal of Chemical Physics},
   volume = {112},
   pages = {8910-8922},
   year = {2000},
   type = {Journal Article}
}

@article{Mobley2006:orientational-restraints,
   author = {Mobley, D.L. and Chodera, J.D. and Dill, K.A.},
   title = {On the use of orientational restraints and symmetry corrections in alchemical free energy calculations},
   journal = {Journal of Chemical Physics},
   volume = {125},
   pages = {084902},
   year = {2006},
   type = {Journal Article}
}

@article{Mongan2007,
   author = {Mongan, John and Simmerling, Carlos and McCammon, J. Andrew and Case, David A. and Onufriev, Alexey},
   title = {Generalized {Born} model with a simple, robust molecular volume correction},
   journal = {Journal of Chemical Theory and Computation},
   volume = {3},
   number = {1},
   pages = {156-169},
   year = {2007},
   type = {Journal Article}
}

@article{Nguyen2013,
   author = {Nguyen, Hai and Roe, Daniel R. and Simmerling, Carlos},
   title = {Improved Generalized {Born} Solvent Model Parameters for Protein Simulations},
   journal = {Journal of Chemical Theory and Computation},
   volume = {9},
   number = {4},
   pages = {2020-2034},
   year = {2013},
   type = {Journal Article}
}

@article{Onufriev2004,
   author = {Onufriev, Alexey and Bashford, Donald and Case, David A.},
   title = {Exploring protein native states and large-scale conformational changes with a modified generalized {Born} model},
   journal = {Proteins},
   volume = {55},
   number = {22},
   pages = {383-394},
   year = {2004},
   type = {Journal Article}
}

@misc{Ponder,
   author = {Ponder, Jay W.},
   title = {Personal communication},
   type = {Personal Communication}
}

@article{Schaefer1998,
   author = {Schaefer, Michael and Bartels, Christian and Karplus, Martin},
   title = {Solution conformations and thermodynamics of structured peptides: molecular dynamics simulation with an implicit solvation model},
   journal = {Journal of Molecular Biology},
   volume = {284},
   number = {3},
   pages = {835-848},
   year = {1998},
   type = {Journal Article}
}

@article{Shirts2008,
   author = {Shirts, Michael R. and Chodera, John D.},
   title = {Statistically optimal analysis of samples from multiple equilibrium states},
   journal = {Journal of Chemical Physics},
   volume = {129},
   pages = {124105},
   year = {2008},
   type = {Journal Article}
}

@article{Shirts2007,
   author = {Shirts, Michael R. and Mobley, David L. and Chodera, John D. and Pande, Vijay S.},
   title = {Accurate and Efficient Corrections for Missing Dispersion Interactions in Molecular Simulations},
   journal = {Journal of Physical Chemistry B},
   volume = {111},
   pages = {13052-13063},
   year = {2007},
   type = {Journal Article}
}

@article{Shirts2013:yank,
   author = {Wang, K.K. and Chodera, J.D. and Yang, Y. and Shirts, Michael R.},
   title = {Identifying ligand binding sites and poses using GPU-accelerated Hamiltonian replica exchange molecular dynamics},
   journal = {Journal of Computed Aided Molecular Design},
   volume = {27},
   pages = {989},
   year = {2013},
   type = {Journal Article}
}

@article{Tironi1995,
   author = {Tironi, Ilario G. and Sperb, René and Smith, Paul E. and van Gunsteren, Wilfred F.},
   title = {A generalized reaction field method for molecular dynamics simulations},
   journal = {Journal of Chemical Physics},
   volume = {102},
   number = {13},
   pages = {5451-5459},
   year = {1995},
   type = {Journal Article}
}

@article{Toukmaji1996,
   author = {Toukmaji, Abdulnour Y.  and Board Jr, John A.},
   title = {{Ewald} summation techniques in perspective: a survey},
   journal = {Computer Physics Communications},
   volume = {95},
   pages = {73-92},
   year = {1996},
   type = {Journal Article}
}

@article{Wang2014,
   author = {Wang, Lee-Ping and Martinez, Todd J. and Pande, Vijay S.},
   title = {Building force fields: an automatic, systematic, and reproducible approach},
   journal = {Journal of Physical Chemistry Letters},
   volume = {5},
   pages = {1885-1891},
   year = {2014},
   type = {Journal Article}
}

@article{Chodera2011,
   author = {Chodera, John D. and Shirts, Michael R.},
   title = {Replica exchange and expanded ensemble simulations as Gibbs sampling: Simple improvements for enhanced mixing},
   journal = {The Journal of Chemical Physics},
   year = {2011},
   volume = {135},
   number = {19},
   eid = {194110},
   url = {http://scitation.aip.org/content/aip/journal/jcp/135/19/10.1063/1.3660669},
   doi = {http://dx.doi.org/10.1063/1.3660669},
}

@incollection{Shoemake1992,
   author = {Shoemake, K.},
   title = {Uniform random rotations},
   editor = {Kirk, D.},
   booktitle = {Graphics Gems III},
   publisher = {Academic},
   address = {New York},
   year = {1992},
   pages = {124-132}
}

@article{Chodera2016,
   author = {Chodera, John D.},
   title = {A Simple Method for Automated Equilibration Detection in Molecular Simulations},
   journal = {Journal of Chemical Theory and Computation},
   volume = {12},
   number = {4},
   pages = {1799-1805},
   year = {2016},
   doi = {10.1021/acs.jctc.5b00784},
   note ={PMID: 26771390},
   URL = {http://dx.doi.org/10.1021/acs.jctc.5b00784},
   eprint = {http://dx.doi.org/10.1021/acs.jctc.5b00784}
}


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%@article{Andersen1980,
   author = {Andersen, Hans C.},
   title = {Molecular dynamics simulations at constant pressure and/or temperature},
   journal = {Journal of Chemical Physics},
   volume = {72},
   number = {4},
   pages = {2384-2393},
   year = {1980},
   type = {Journal Article}
}

%@article{Aqvist2004,
   author = {Åqvist, Johan and Wennerström, Petra and Nervall, Martin and Bjelic, Sinisa and Brandsdal, Bjørn O.},
   title = {Molecular dynamics simulations of water and biomolecules with a {Monte Carlo} constant pressure algorithm},
   journal = {Chemical Physics Letters},
   volume = {384},
   pages = {288-294},
   year = {2004},
   type = {Journal Article}
}

%@article{Ceriotti2010,
   author = {Ceriotti, M. and Parrinello, M. and Markland, Thomas E. and Manolopoulos, David E.},
   title = {Efficient stochastic thermostatting of path integral molecular dynamics},
   journal = {Journal of Chemical Physics},
   volume = {133},
   number = {12},
   year = {2010},
   type = {Journal Article}
}

%@article{Chow1995,
   author = {Chow, Kim-Hung and Ferguson, David M.},
   title = {Isothermal-isobaric molecular dynamics simulations with {Monte Carlo} volume sampling},
   journal = {Computer Physics Communications},
   volume = {91},
   pages = {283-289},
   year = {1995},
   type = {Journal Article}
}

%@article{Craig2004,
   author = {Craig, I. R. and Manolopoulos, David E.},
   title = {Quantum statistics and classical mechanics: Real time correlation functions from ring polymer molecular dynamics},
   journal = {Journal of Chemical Physics},
   volume = {121},
   pages = {3368-3373},
   year = {2004},
   type = {Journal Article}
}

%@article{Duan2003,
   author = {Duan, Y.; Wu, C. and Chowdhury, S. and Lee, M.C. and Xiong, G. and Zhang, W. and Yang, R. and Cieplak, P. and Luo, R. and Lee, T.},
   title = {A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations},
   journal = {Journal of Computational Chemistry},
   volume = {24},
   pages = {1999-2012},
   year = {2003},
   type = {Journal Article}
}

%@article{Hall1984,
   author = {Hall, Randall W. and Berne, B. J.},
   title = {Nonergodicity in path integral molecular dynamics},
   journal = {Journal of Chemical Physics},
   volume = {81},
   number = {8},
   year = {1984},
   type = {Journal Article}
}

%@article{Hornak2006,
   author = {Hornak, V. and Abel, R. and Okur, A. and Strockbine, B. and Roitberg, A. and Simmerling, C.},
   title = {Comparison of multiple {Amber} force fields and development of improved protein backbone parameters},
   journal = {Proteins},
   volume = {65},
   pages = {712-725},
   year = {2006},
   type = {Journal Article}
}

%@article{Izaguirre2010,
   author = {Izaguirre, Jesús A. and Sweet, Chris R. and Pande, Vijay S.},
   title = {Multiscale dynamics of macromolecules using {Normal Mode Langevin}},
   journal = {Pacific Symposium on Biocomputing},
   volume = {15},
   pages = {240-251},
   year = {2010},
   type = {Journal Article}
}

%@inbook{Kollman1997,
   author = {Kollman, P.A. and Dixon, R. and Cornell, W. and Fox, T. and Chipot, C. and Pohorille, A.},
   title = {Computer Simulation of Biomolecular Systems},
   editor = {Wilkinson, A. and Weiner, P. and van Gunsteren, Wilfred F.},
   publisher = {Elsevier},
   volume = {3},
   pages = {83-96},
   year = {1997},
   type = {Book Section}
}

%@article{Labute2008,
   author = {Labute, Paul},
   title = {The generalized {Born}/volume integral implicit solvent model: Estimation of the free energy of hydration using {London} dispersion instead of atomic surface area},
   journal = {Journal of Computational Chemistry},
   volume = {29},
   number = {10},
   pages = {1693-1698},
   year = {2008},
   type = {Journal Article}
}

%@article{Lamoureux2003,
   author = {Lamoureux, Guillaume and Roux, Benoit},
   title = {Modeling induced polarization with classical {Drude} oscillators: Theory and molecular dynamics simulation algorithm},
   journal = {Journal of Chemical Physics},
   volume = {119},
   number = {6},
   pages = {3025-3039},
   year = {2003},
   type = {Journal Article}
}

%@article{Li2010,
   author = {Li, D.W. and Br{\"u}schweiler, R.},
   title = {{NMR}-based protein potentials},
   journal = {Angewandte Chemie International Edition},
   volume = {49},
   pages = {6778-6780},
   year = {2010},
   type = {Journal Article}
}

%@article{Lindorff-Larsen2010,
   author = {Lindorff-Larsen, K. and Piana, S. and Palmo, K. and Maragakis, P. and Klepeis, J. and Dror, R.O. and Shaw, D.E.},
   title = {Improved side-chain torsion potentials for the {Amber ff99SB} protein force field},
   journal = {Proteins},
   volume = {78},
   pages = {1950-1958},
   year = {2010},
   type = {Journal Article}
}

%@article{Liu1989,
   author = {Liu, Dong C. and Nocedal, Jorge},
   title = {On the Limited Memory {BFGS} Method For Large Scale Optimization},
   journal = {Mathematical Programming},
   volume = {45},
   pages = {503-528},
   year = {1989},
   type = {Journal Article}
}

%@article{Lopes2013,
    author = {Lopes, Pedro E. M. and Huang, Jing and Shim, Jihyun and Luo, Yun and Li, Hui and Roux, Benoît and MacKerell, Alexander D.},
    title = {Polarizable Force Field for Peptides and Proteins Based on the Classical {Drude} Oscillator},
    journal = {Journal of Chemical Theory and Computation},
    volume = {9},
    number = {12},
    pages = {5430-5449},
    year = {2013},
    type = {Journal Article}
}

%@article{Markland2008,
   author = {Markland, Thomas E. and Manolopoulos, David E.},
   title = {An efficient ring polymer contraction scheme for imaginary time path integral simulations},
   journal = {Journal of Chemical Physics},
   volume = {129},
   number = {2},
   year = {2008},
   type = {Journal Article}
}

%@article{Parrinello1984,
   author = {Parrinello, M. and Rahman, A.},
   title = {Study of an {F} center in molten {KCl}},
   journal = {Journal of Chemical Physics},
   volume = {80},
   number = {2},
   pages = {860-867},
   year = {1984},
   type = {Journal Article}
}

%@article{Ren2002,
   author = {Ren, P. and Ponder, Jay W.},
   title = {A Consistent Treatment of Inter- and Intramolecular Polarization in Molecular Mechanics Calculations},
   journal = {Journal of Computational Chemistry},
   volume = {23},
   pages = {1497-1506},
   year = {2002},
   type = {Journal Article}
}

%@article{Ren2003,
   author = {Ren, P. and Ponder, Jay W.},
   title = {Polarizable Atomic Multipole Water Model for Molecular Mechanics Simulation},
   journal = {Journal of Physical Chemistry B},
   volume = {107},
   pages = {5933-5947},
   year = {2003},
   type = {Journal Article}
}

%@article{Schnieders2007,
   author = {Schnieders, Michael J. and Ponder, Jay W.},
   title = {Polarizable Atomic Multipole Solutes in a Generalized {Kirkwood} Continuum},
   journal = {Journal of Chemical Theory and Computation},
   volume = {3},
   pages = {2083-2097},
   year = {2007},
   type = {Journal Article}
}


%@article{Shi2013,
   author = {Shi, Yue and Xia, Zhen and Zhang, Jiajing and Best, Robert and Wu, Chuanjie and Ponder, Jay W. and Ren, Pengyu},
   title = {Polarizable Atomic Multipole-Based {AMOEBA} Force Field for Proteins},
   journal = {Journal of Chemical Theory and Computation},
   volume = {9},
   number = {9},
   pages = {4046-4063},
   year = {2013},
   type = {Journal Article}
}

%@article{Shirts2005,
   author = {Shirts, Michael R. and Pande, Vijay S.},
   title = {Solvation free energies of amino acid side chain analogs for common molecular mechanics water models},
   journal = {Journal of Chemical Physics},
   volume = {132},
   pages = {134508},
   year = {2005},
   type = {Journal Article}
}

%@article{Sindhikara2009,
  author =   {Sindhikara, Daniel J. and Kim, Seonah and Voter,
                  Arthur F. and Roitberg, Adrian E.},
  title =    {{Bad Seeds Sprout Perilous Dynamics: Stochastic
                  Thermostat Induced Trajectory Synchronization in
                  Biomolecules}},
  journal =  {Journal of Chemical Theory and Computation},
  year =     2009,
  volume =   5,
  number =   6,
  pages =    {1624--1631},
  month =    {April},
}

%@article{Srinivasan1999,
   author = {Srinivasan, J and Trevathan, M. W. and Beroza, P. and Case, D. A.},
   title = {Application of a pairwise generalized {Born} model to proteins and nucleic acids: inclusion of salt effects},
   journal = {Theor. Chem. Acc.},
   volume = {101},
   pages = {426-434},
   year = {1999},
   type = {Journal Article}
}

%@article{Thole1981,
   author = {Thole, B. T.},
   title = {Molecular polarizabilities calculated with a modified dipole interaction},
   journal = {Chemical Physics},
   volume = {59},
   number = {3},
   pages = {341-350},
   year = {1981},
   type = {Journal Article}
}

%@misc{Tinker,
   author = {Ponder, Jay W.},
   title = {{TINKER - Software Tools for Molecular Design, 4.2}},
   year = {2004}
}

%@article{Uberuaga2004,
  author =   {Blas P. Uberuaga and Marian Anghel and Arthur
                  F. Voter},
  title =    {{Synchronization of trajectories in canonical
                  molecular-dynamics simulations: observation,
                  explanation, and exploitation}},
  journal =  {Journal of Chemical Physics},
  year =     2004,
  key =      {synchronization, parallelization},
  volume =   120,
  number =   14,
  pages =    {6363--6374},
}

%@article{Wang2000,
   author = {Wang, J. and Cieplak, P. and Kollman, P.A.},
   title = {How well does a restrained electrostatic potential ({RESP}) model perform in calculating conformational energies of organic and biological molecules?},
   journal = {Journal of Computational Chemistry},
   volume = {21},
   pages = {1049-1074},
   year = {2000},
   type = {Journal Article}
}

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