creative-connections/aurelia-bodylight-plugin

/**
 * pdbe-molstar
 * @version 1.1.1
 * @link https://github.com/PDBeurope/pdbe-molstar
 * @license Apache 2.0
 */
/**
 * Copyright 2019-2020 Mandar Deshpande <mandar@ebi.ac.uk>
 * European Bioinformatics Institute (EBI, http://www.ebi.ac.uk/)
 * European Molecular Biology Laboratory (EMBL, http://www.embl.de/)
 * Licensed under the Apache License, Version 2.0 (the "License");
 * you may not use this file except in compliance with the License.
 * You may obtain a copy of the License at 
 * http://www.apache.org/licenses/LICENSE-2.0
 * 
 * Unless required by applicable law or agreed to in writing, software
 * distributed under the License is distributed on an "AS IS" BASIS, 
 * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 * See the License for the specific language governing permissions and 
 * limitations under the License.
 */
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/*! *****************************************************************************
Copyright (c) Microsoft Corporation.

Permission to use, copy, modify, and/or distribute this software for any
purpose with or without fee is hereby granted.

THE SOFTWARE IS PROVIDED "AS IS" AND THE AUTHOR DISCLAIMS ALL WARRANTIES WITH
REGARD TO THIS SOFTWARE INCLUDING ALL IMPLIED WARRANTIES OF MERCHANTABILITY
AND FITNESS. IN NO EVENT SHALL THE AUTHOR BE LIABLE FOR ANY SPECIAL, DIRECT,
INDIRECT, OR CONSEQUENTIAL DAMAGES OR ANY DAMAGES WHATSOEVER RESULTING FROM
LOSS OF USE, DATA OR PROFITS, WHETHER IN AN ACTION OF CONTRACT, NEGLIGENCE OR
OTHER TORTIOUS ACTION, ARISING OUT OF OR IN CONNECTION WITH THE USE OR
PERFORMANCE OF THIS SOFTWARE.
***************************************************************************** */
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this.asImmutable().asTransient()},e.prototype.addChild=function(e,t){if(this.changeChildren(),this.childMutations.has(e))this.childMutations.get(e).add(t);else{var r=this.children.get(e).asMutable();r.add(t),this.children.set(e,r),this.childMutations.set(e,r)}},e.prototype.removeChild=function(e,t){if(this.changeChildren(),this.childMutations.has(e))this.childMutations.get(e).remove(t);else{var r=this.children.get(e).asMutable();r.remove(t),this.children.set(e,r),this.childMutations.set(e,r)}},e.prototype.clearRoot=function(){var e=d.a.RootRef;if(0!==this.children.get(e).size){this.changeChildren();var t=Object(l.OrderedSet)();this.children.set(e,t),this.childMutations.set(e,t)}},e.prototype.mutateDependency=function(e,t,r){var n=this.dependencyMutations.get(e);if(!n){var i=this.dependencies.get(e);if(!i&&"remove"===r)return;this.changeDependencies(),n=i?i.asMutable():Object(l.OrderedSet)().asMutable(),this.dependencyMutations.set(e,n),this.dependencies.set(e,n)}"add"===r?n.add(t):n.remove(t)},e.prototype.changeParent=function(e,t){v(this.transforms,e);var r=this.transforms.get(e);this.removeChild(r.parent,e),this.addChild(t,e),this.changeNodes(),this.transforms.set(e,d.a.withParent(r,t))},e.prototype.add=function(e){var t=e.ref;this.transforms.has(e.ref)&&(this.transforms.get(e.ref).parent!==e.parent&&function(e){throw new Error("Transform '"+e+"' is already present in the tree.")}(e.ref));var r=this.children.get(e.parent);if(r||function(e){throw new Error("Parent '"+e+"' must be present in the 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r=this.transforms.get(e);if(this._stateUpdates&&this._stateUpdates.has(e))return d.a.assignState(r.state,t),r;this._stateUpdates||(this._stateUpdates=new Set),this._stateUpdates.add(r.ref),this.changeNodes();var n=d.a.withState(r,t);return this.transforms.set(e,n),n},e.prototype.remove=function(e){var t=this.transforms.get(e);if(!t)return[];var r=c.subtreePostOrder(this,t);if(e===d.a.RootRef){if(r.pop(),0===r.length)return r;this.clearRoot()}else{if(0===r.length)return r;this.removeChild(t.parent,t.ref)}this.changeNodes(),this.changeChildren();for(var n=0,i=r;n<i.length;n++){var a=i[n];this.transforms.delete(a.ref),this.children.delete(a.ref),this._childMutations&&this._childMutations.delete(a.ref)}for(var o=[],s=0,u=r;s<u.length;s++){if((a=u[s]).dependsOn)for(var l=0,f=a.dependsOn;l<f.length;l++){var p=f[l];this.transforms.has(p)&&this.mutateDependency(p,a.ref,"remove")}if(this.dependencies.has(a.ref)){var m=this.dependencies.get(a.ref).toArray();this.changeDependencies(),this.dependencies.delete(a.ref),this._dependencyMutations&&this._dependencyMutations.delete(a.ref);for(var h=0,g=m;h<g.length;h++){var v=g[h];if(this.transforms.has(v))for(var b=0,y=this.remove(v);b<y.length;b++){var _=y[b];o[o.length]=_}}}}for(var S=0,x=o;S<x.length;S++){v=x[S];r[r.length]=v}return r},e.prototype.asImmutable=function(){return this.changedNodes||this.changedChildren||this._childMutations?(this._childMutations&&this._childMutations.forEach(h,this.children),this._dependencyMutations&&this._dependencyMutations.forEach(g,this.dependencies),c.create(this.changedNodes?this.transforms.asImmutable():this.transforms,this.changedChildren?this.children.asImmutable():this.children,this.changedDependencies?this.dependencies.asImmutable():this.dependencies)):this.tree},e}();function h(e,t){this.set(t,e.asImmutable())}function g(e,t){0===e.size?this.delete(t):this.set(t,e.asImmutable())}function 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n(this.state,t,this)},e.prototype.toRoot=function(){return new n(this.state,this.state.tree.root.ref,this)},e.prototype.delete=function(e){var t=o.resolveRef(e);return t&&this.state.tree.transforms.has(t)?(this.editInfo.count++,this.state.tree.remove(t),this.state.actions.push({kind:"delete",ref:t}),this):this},e.prototype.getTree=function(){return t(this.state)},e.prototype.commit=function(e){if(!this.state.state)throw new Error("Cannot commit template tree");return this.state.state.runTask(this.state.state.updateTree(this,e))},e}();e.Root=r;var n=function(){function e(e,t,r){if(this.state=e,this.root=r,this.ref=t,!this.state.tree.transforms.has(t))throw new Error("Could not find node '"+t+"'.")}return Object.defineProperty(e.prototype,"editInfo",{get:function(){return this.state.editInfo},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"selector",{get:function(){return new u(this.ref,this.state.state)},enumerable:!1,configurable:!0}),e.prototype.getApplyRoot=function(){return c.getDecoratorRoot(this.state.tree,this.ref)},e.prototype.apply=function(t,r,n){if(t.definition.isDecorator)return this.insert(t,r,n);var i=this.getApplyRoot(),a=t.apply(i,r,n);return this.state.tree.add(a),this.editInfo.count++,this.editInfo.lastUpdate=a.ref,this.state.actions.push({kind:"add",transform:a}),new e(this.state,a.ref,this.root)},e.prototype.applyOrUpdate=function(e,t,r,n){if(this.state.tree.transforms.has(e)){var i=this.to(e);return r&&i.update(r),i}return this.apply(t,r,Object(y.__assign)(Object(y.__assign)({},n),{ref:e}))},e.prototype.applyOrUpdateTagged=function(t,r,n,i){if(r.definition.isDecorator)throw new Error("Can't use applyOrUpdateTagged on decorator transformers.");for(var a=this.getApplyRoot(),o=this.state.tree.children.get(a).values();;){var s=o.next();if(s.done)break;var u=this.state.tree.transforms.get(s.value);if(u&&d.a.hasTags(u,t)){var c=this.to(s.value);return c.updateTagged(n,C(u.tags,t,i&&i.tags)),c}}var l=r.apply(a,n,Object(y.__assign)(Object(y.__assign)({},i),{tags:C(t,i&&i.tags)}));return this.state.tree.add(l),this.editInfo.count++,this.editInfo.lastUpdate=l.ref,this.state.actions.push({kind:"add",transform:l}),new e(this.state,l.ref,this.root)},e.prototype.group=function(e,t,r){return this.apply(e,t,r)},e.prototype.insert=function(t,r,n){var i=this.state.tree.children.get(this.ref).toArray(),a=t.apply(this.ref,r,n);this.state.tree.add(a);for(var o=0,s=i;o<s.length;o++){var u=s[o];this.state.tree.changeParent(u,a.ref)}return this.editInfo.count++,this.editInfo.lastUpdate=a.ref,this.state.actions.push({kind:"insert",ref:this.ref,transform:a}),new e(this.state,a.ref,this.root)},e.prototype.updateTagged=function(e,t){(this.state.tree.setParams(this.ref,e)||this.state.tree.setTags(this.ref,t))&&(this.editInfo.count++,this.editInfo.lastUpdate=this.ref,this.state.actions.push({kind:"update",ref:this.ref,params:e}))},e.prototype.update=function(e,t){var r;if(t){var n=this.state.tree.transforms.get(this.ref);r=Object(w.b)(n.params,t)}else r="function"==typeof e?Object(w.b)(this.state.tree.transforms.get(this.ref).params,e):e;return this.state.tree.setParams(this.ref,r)&&(this.editInfo.count++,this.editInfo.lastUpdate=this.ref,this.state.actions.push({kind:"update",ref:this.ref,params:r})),this.root},e.prototype.to=function(e){return this.root.to(e)},e.prototype.toRoot=function(){return this.root.toRoot()},e.prototype.delete=function(e){return this.root.delete(e)},e.prototype.getTree=function(){return t(this.state)},e.prototype.commit=function(e){if(!this.state.state)throw new Error("Cannot commit template tree");return this.state.state.runTask(this.state.state.updateTree(this,e))},e}();e.To=n}(x||(x={}));var j,P=function(){function e(){this.ev=O.RxEventHelper.create(),this.actions=new Map,this.fromTypeIndex=new Map,this.events={added:this.ev(),removed:this.ev()}}return e.prototype.add=function(e){var t=_.a.is(e)?e.toAction():e;if(this.actions.has(t.id))return this;this.actions.set(t.id,t);for(var r=0,n=t.definition.from;r<n.length;r++){var i=n[r];this.fromTypeIndex.has(i.type)?this.fromTypeIndex.get(i.type).push(t):this.fromTypeIndex.set(i.type,[t])}return this.events.added.next(),this},e.prototype.remove=function(e){var t=_.a.is(e)?e.toAction().id:a.c.is(e)?e:e.id,r=this.actions.get(t);if(!r)return this;this.actions.delete(t);for(var n=0,i=r.definition.from;n<i.length;n++){var o=i[n],s=this.fromTypeIndex.get(o.type);s&&(Object(p.arraySetRemove)(s,r),0===s.length&&this.fromTypeIndex.delete(o.type))}return this.events.removed.next(),this},e.prototype.fromCell=function(e,t){var r=e.obj;if(!r)return[];var n=this.fromTypeIndex.get(r.type);if(!n)return[];for(var i=!1,a=0,o=n;a<o.length;a++){if((l=o[a]).definition.isApplicable){i=!0;break}}if(!i)return n;for(var s=[],u=0,c=n;u<c.length;u++){var l;(l=c[u]).definition.isApplicable?l.definition.isApplicable(r,e.transform,t)&&s.push(l):s.push(l)}return s},e.prototype.dispose=function(){this.ev.dispose()},e}(),E=r(249),A=r(75),D=r(2),T=r(311),I=r(62),M=function(){function e(){this.queue=[],this.signal=new I.a}return Object.defineProperty(e.prototype,"length",{get:function(){return this.queue.length},enumerable:!1,configurable:!0}),e.prototype.enqueue=function(e){return this.queue.push(e),1===this.queue.length||this.waitFor(e)},e.prototype.handled=function(e){Object(p.arrayRemoveInPlace)(this.queue,e),this.queue.length>0&&this.signal.next({v:this.queue[0],stillPresent:!0})},e.prototype.remove=function(e){var t=Object(p.arrayRemoveInPlace)(this.queue,e);return t&&this.signal.next({v:e,stillPresent:!1}),t},e.prototype.waitFor=function(e){var t=this;return new Promise((function(r){var n=t.signal.subscribe((function(t){var i=t.v,a=t.stillPresent;i===e&&(n.unsubscribe(),r(a))}))}))},e}(),k=r(48),B=r(57),V=function(){function e(e,t){var r=this;this.errorFree=!0,this.ev=O.RxEventHelper.create(),this.globalContext=void 0,this.events={cell:{stateUpdated:this.ev(),created:this.ev(),removed:this.ev()},object:{updated:this.ev(),created:this.ev(),removed:this.ev()},log:this.ev(),changed:this.ev(),historyUpdated:this.ev()},this.behaviors={currentObject:this.ev.behavior({state:this,ref:d.a.RootRef}),isUpdating:this.ev.behavior(!1)},this.actions=new P,this.cells=new Map,this.spine=new T.a.Impl(this.cells),this.tryGetCellData=function(e){var t,n,i=null===(n=null===(t=r.cells.get(e))||void 0===t?void 0:t.obj)||void 0===n?void 0:n.data;if(!e)throw new Error("Cell '"+e+"' data undefined.");return i},this.historyCapacity=5,this.history=[],this.undoingHistory=!1,this.inTransaction=!1,this.inTransactionError=!1,this._inUpdate=!1,this.reverted=!1,this.updateQueue=new M,this._tree=c.createEmpty(d.a.createRoot(t&&t.rootState)).asTransient();var n=this._tree.root;this.runTask=t.runTask,void 0!==(null==t?void 0:t.historyCapacity)&&(this.historyCapacity=t.historyCapacity),this.cells.set(n.ref,{parent:this,transform:n,sourceRef:void 0,obj:e,status:"ok",state:Object(y.__assign)({},n.state),errorText:void 0,params:{definition:{},values:{}},paramsNormalizedVersion:n.version,dependencies:{dependentBy:[],dependsOn:[]},cache:{}}),this.globalContext=t&&t.globalContext}return Object.defineProperty(e.prototype,"tree",{get:function(){return this._tree},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"transforms",{get:function(){return this._tree.transforms},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"current",{get:function(){return this.behaviors.currentObject.value.ref},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"root",{get:function(){return this.cells.get(this._tree.root.ref)},enumerable:!1,configurable:!0}),e.prototype.build=function(){return new x.Root(this.tree,this)},e.prototype.addHistory=function(e,t){0!==this.historyCapacity&&(this.history.unshift([e,t||"Update"]),this.history.length>this.historyCapacity&&this.history.pop(),this.events.historyUpdated.next({state:this}))},e.prototype.clearHistory=function(){0!==this.history.length&&(this.history=[],this.events.historyUpdated.next({state:this}))},Object.defineProperty(e.prototype,"latestUndoLabel",{get:function(){return this.history.length>0?this.history[0][1]:void 0},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"canUndo",{get:function(){return this.history.length>0},enumerable:!1,configurable:!0}),e.prototype.undo=function(){var e=this;return S.b.create("Undo",(function(t){return Object(y.__awaiter)(e,void 0,void 0,(function(){var e;return Object(y.__generator)(this,(function(r){switch(r.label){case 0:if(!(e=this.history.shift()))return[2];this.events.historyUpdated.next({state:this}),this.undoingHistory=!0,r.label=1;case 1:return r.trys.push([1,,3,4]),[4,this.updateTree(e[0],{canUndo:!1}).runInContext(t)];case 2:return r.sent(),[3,4];case 3:return this.undoingHistory=!1,[7];case 4:return[2]}}))}))}))},e.prototype.getSnapshot=function(){return{tree:c.toJSON(this._tree)}},e.prototype.setSnapshot=function(e){var t=c.fromJSON(e.tree);return this.updateTree(t)},e.prototype.setCurrent=function(e){this.behaviors.currentObject.next({state:this,ref:e})},e.prototype.updateCellState=function(e,t){var r=this.cells.get(e);if(r){var n="function"==typeof t?t(r.state):t;d.a.assignState(r.state,n)&&(r.transform=this._tree.assignState(r.transform.ref,n),this.events.cell.stateUpdated.next({state:this,ref:e,cell:r}))}},e.prototype.dispose=function(){this.ev.dispose(),this.actions.dispose()},e.prototype.select=function(e){return b.select(e,this)},e.prototype.selectQ=function(e){return"string"==typeof e?b.select(e,this):b.select(e(b.Generators),this)},e.prototype.applyAction=function(e,t,r){var n=this;return void 0===r&&(r=d.a.RootRef),S.b.create("Apply Action",(function(i){var a=n.cells.get(r);if(!a)throw new Error("'"+r+"' does not exist.");if("ok"!==a.status)throw new Error("Action cannot be applied to a cell with status '"+a.status+"'");return ee(e.definition.run({ref:r,cell:a,a:a.obj,params:t,state:n},n.globalContext),i)}))},e.prototype.transaction=function(e,t){var r=this;return S.b.create("State Transaction",(function(n){return Object(y.__awaiter)(r,void 0,void 0,(function(){var r,i,a,o;return Object(y.__generator)(this,(function(s){switch(s.label){case 0:r=this.inTransaction,i=this._tree.asImmutable(),a=!1,s.label=1;case 1:return s.trys.push([1,5,8,9]),r||this.behaviors.isUpdating.next(!0),this.inTransaction=!0,this.inTransactionError=!1,[4,e(n)];case 2:return s.sent(),this.inTransactionError?(a=!0,[4,this.updateTree(i).runInContext(n)]):[3,4];case 3:s.sent(),s.label=4;case 4:return[3,9];case 5:return o=s.sent(),a?[3,7]:(a=!0,[4,this.updateTree(i).runInContext(n)]);case 6:s.sent(),this.events.log.next(E.a.error(""+o)),s.label=7;case 7:if(r)throw this.inTransactionError=!0,o;if(null==t?void 0:t.rethrowErrors)throw o;return[3,9];case 8:return r||(this.inTransaction=!1,this.events.changed.next({state:this,inTransaction:!1}),this.behaviors.isUpdating.next(!1),a||((null==t?void 0:t.canUndo)?this.addHistory(i,"string"==typeof t.canUndo?t.canUndo:void 0):this.clearHistory())),[7];case 9:return[2]}}))}))}))},Object.defineProperty(e.prototype,"inUpdate",{get:function(){return this._inUpdate},enumerable:!1,configurable:!0}),e.prototype.updateTree=function(e,t){var r=this,n={tree:e,options:t};return S.b.create("Update Tree",(function(i){return Object(y.__awaiter)(r,void 0,void 0,(function(){var r,a,o,s;return Object(y.__generator)(this,(function(c){switch(c.label){case 0:return[4,this.updateQueue.enqueue(n)];case 1:if(!c.sent())return[2];this._inUpdate=!0,r=(null==t?void 0:t.canUndo)?this._tree.asImmutable():void 0,a=!1,this.inTransaction||this.behaviors.isUpdating.next(!0),c.label=2;case 2:if(c.trys.push([2,,7,8]),x.is(e)){if(e.editInfo.applied)throw new Error("This builder has already been applied. Create a new builder for further state updates");e.editInfo.applied=!0}return this.reverted=!1,t&&(t.revertIfAborted||t.revertOnError)?[4,this._revertibleTreeUpdate(i,n,t)]:[3,4];case 3:return s=c.sent(),[3,6];case 4:return[4,this._updateTree(i,n)];case 5:s=c.sent(),c.label=6;case 6:return o=s,a=this.reverted,o.ctx.hadError&&(this.inTransactionError=!0),o.cell?[2,new u(o.cell.transform.ref,this)]:[2];case 7:return this._inUpdate=!1,this.updateQueue.handled(n),this.inTransaction||(this.behaviors.isUpdating.next(!1),(null==t?void 0:t.canUndo)?a||this.addHistory(r,"string"==typeof t.canUndo?t.canUndo:void 0):this.undoingHistory||this.clearHistory()),[7];case 8:return[2]}}))}))}),(function(){r.updateQueue.remove(n)}))},e.prototype._revertibleTreeUpdate=function(e,t,r){return Object(y.__awaiter)(this,void 0,void 0,(function(){var n,i;return Object(y.__generator)(this,(function(a){switch(a.label){case 0:return n=this.tree,[4,this._updateTree(e,t)];case 1:return i=a.sent(),(i.ctx.hadError||i.ctx.wasAborted)&&r.revertOnError||i.ctx.wasAborted&&r.revertIfAborted?(this.reverted=!0,[4,this._updateTree(e,{tree:n,options:t.options})]):[3,3];case 2:return[2,a.sent()];case 3:return[2,i]}}))}))},e.prototype._updateTree=function(e,t){return Object(y.__awaiter)(this,void 0,void 0,(function(){var r,n,i;return Object(y.__generator)(this,(function(a){switch(a.label){case 0:r=!1,n=this.updateTreeAndCreateCtx(t.tree,e,t.options),a.label=1;case 1:return a.trys.push([1,,3,4]),[4,L(n)];case 2:return r=a.sent(),x.isTo(t.tree)?(i=this.select(t.tree.ref)[0],[2,{ctx:n,cell:i}]):[2,{ctx:n}];case 3:return this.spine.current=void 0,r&&this.events.changed.next({state:this,inTransaction:this.inTransaction}),[7];case 4:return[2]}}))}))},e.prototype.updateTreeAndCreateCtx=function(e,t,r){var n=(x.is(e)?e.getTree():e).asTransient(),i=this._tree;this._tree=n;var a=this.cells,o={parent:this,editInfo:x.is(e)?e.editInfo:void 0,errorFree:this.errorFree,taskCtx:t,oldTree:i,tree:n,cells:this.cells,spine:this.spine,results:[],options:Object(y.__assign)(Object(y.__assign)({},R),r),changed:!1,hadError:!1,wasAborted:!1,newCurrent:void 0,getCellData:function(e){var t;return null===(t=a.get(e).obj)||void 0===t?void 0:t.data}};return this.errorFree=!0,o},e}();(j=V||(V={})).create=function(e,t){return new j(e,t)},(j.ObjectEvent||(j.ObjectEvent={})).isCell=function(e,t){return!!t&&e.ref===t.transform.ref&&e.state===t.parent};var R={doNotLogTiming:!1,doNotUpdateCurrent:!0,revertIfAborted:!1,revertOnError:!1,canUndo:!1};function L(e){return Object(y.__awaiter)(this,void 0,void 0,(function(){var t,r,i,a,o,s,u,l,d,f,p,m,h,g,v,b,_,S,x,O,w,C,j,P,E,A,D,T,I;return Object(y.__generator)(this,(function(y){switch(y.label){case 0:if(t=!(!e.editInfo||1!==e.editInfo.count||!e.editInfo.lastUpdate||e.editInfo.sourceTree!==e.oldTree),i=[],t)r=[],a=[e.editInfo.lastUpdate];else{for(r=function(e){var t={newTree:e.tree,cells:e.cells,deletes:[]};return c.doPostOrder(e.oldTree,e.oldTree.root,t,F),t.deletes}(e),T=e.parent.current,o=!1,s=0,u=r;s<u.length;s++)if((b=u[s])===T){o=!0;break}for(o&&(l=X(e.oldTree,T,r,e.cells),e.parent.setCurrent(l)),v=r.length-1;v>=0;v--)(O=e.cells.get(r[v]))&&J(O.transform,O.obj,null==O?void 0:O.transform.params,O.cache,e.parent.globalContext);for(d=0,f=r;d<f.length;d++)b=f[d],(O=e.cells.get(b))&&(O.parent=void 0,G(O)),p=O&&O.obj,e.cells.delete(b),i.push(p);M=e.cells,k=e.tree,V={roots:[],cells:M},c.doPreOrder(k,k.root,V,N),a=V.roots}for(m=function(e,t){for(var r,n={ctx:e,visited:new Set,added:[]},i=0,a=t;i<a.length;i++){var o=a[i];c.doPreOrder(e.tree,e.tree.transforms.get(o),n,q)}for(var s=0,u=n.added;s<u.length;s++){W(u[s],e)}return n.visited.forEach((function(t){for(var i=0,a=e.cells.get(t).dependencies.dependentBy;i<a.length;i++){var o=a[i];n.visited.has(o.transform.ref)||(r||(r=B.c.create()),B.c.add(r,o.transform.ref,o))}})),{added:n.added,dependent:r?r.array:void 0}}(e,a),h=0,g=m.added;h<g.length;h++)O=g[h],e.parent.events.cell.created.next({state:e.parent,ref:O.transform.ref,cell:O});for(v=0;v<r.length;v++)b=r[v],_=e.oldTree.transforms.get(b).parent,e.parent.events.object.removed.next({state:e.parent,ref:b,obj:i[v]}),e.parent.events.cell.removed.next({state:e.parent,ref:b,parent:_});if(i.length&&(i=[]),m.dependent)for(S=0,x=m.dependent;S<x.length;S++)O=x[S],a.push(O.transform.ref);!function(e,t){for(var r=0,n=t;r<n.length;r++){var i=n[r];c.doPreOrder(e.tree,e.tree.transforms.get(i),e,H)}}(e,a),w=0,C=a,y.label=1;case 1:return w<C.length?(j=C[w],[4,K(e,j)]):[3,4];case 2:y.sent(),y.label=3;case 3:return w++,[3,1];case 4:for(e.editInfo||function(e){c.doPreOrder(e.tree,e.tree.root,e,U)}(e),P=e.newCurrent,E=0,A=e.results;E<A.length;E++)"created"===(D=A[E]).action?(e.parent.events.object.created.next({state:e.parent,ref:D.ref,obj:D.obj}),e.newCurrent||e.tree.transforms.get(D.ref).state.isGhost||D.obj===n.Null||(P=D.ref)):"updated"===D.action?e.parent.events.object.updated.next({state:e.parent,ref:D.ref,action:"in-place",obj:D.obj,oldData:D.oldData}):"replaced"===D.action&&e.parent.events.object.updated.next({state:e.parent,ref:D.ref,action:"recreate",obj:D.obj,oldObj:D.oldObj});return P?e.options.doNotUpdateCurrent||e.parent.setCurrent(P):(T=e.parent.current,(I=e.cells.get(T))&&(I.obj===n.Null||"error"===I.status&&I.errorText===Q)&&(P=X(e.oldTree,T,[],e.cells),e.parent.setCurrent(P))),[2,r.length>0||a.length>0||e.changed]}var M,k,V}))}))}function N(e,t,r){var i=r.cells.get(e.ref);return i&&i.transform.version===e.version?"error"!==i.status&&(!i||i.obj!==n.Null):(r.roots.push(e.ref),!1)}function 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PERFORMANCE OF THIS SOFTWARE.
***************************************************************************** */
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o=this.getCoarseConformation(),s=C(this.kind,r);a||(a=Object(n.__assign)({},this.props),e.isSameConformation(this,r)||(a.boundary=void 0,a.lookup3d=void 0,a.principalAxes=void 0));var u=o!==s?i.a.createMapping(this.conformation.operator,s):this.conformation;return new t(this.id,this.invariantId,this.chainGroupId,this.traits,r,this.kind,this.elements,u,a)},Object.defineProperty(t.prototype,"boundary",{get:function(){if(this.props.boundary)return this.props.boundary;var e=this.getCoarseConformation(),t=e.x,r=e.y,n=e.z;return this.props.boundary=Object(_.a)({x:t,y:r,z:n,indices:this.elements}),this.props.boundary},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"lookup3d",{get:function(){if(this.props.lookup3d)return this.props.lookup3d;var e=this.getCoarseConformation(),t=e.x,r=e.y,n=e.z;return 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g.Mat4.areEqual(e.conformation.operator.matrix,t.conformation.operator.matrix,1e-6)},e.areConformationsEqual=function(e,t){return!!l.SortedArray.areEqual(e.elements,t.elements)&&T(e,t.model)},e.isSameConformation=T,e.getModelConformationOfKind=I,e.getConformation=function(e){return I(e.kind,e.model)},e.getModelHierarchyOfKind=M,e.getHierarchy=function(e){return M(e.kind,e.model)}}(y||(y={}));t.a=y},function(e,t,r){"use strict";r.d(t,"a",(function(){return n}));var n,i=r(0),a=r(5),o=r(1),s=r(9),u=r(122),c=r(124),l=r(53),d=r(115),f=r(12),p=r(2),m=r(52),h=r(30),g=r(129),v=r(130),b=r(136);!function(e){function t(e,t,r,i,o,c,l){return l?function(e,t,r,n,i,o,s){return s.vertexCount=i,s.triangleCount=o,a.e.update(s.vertexBuffer,e),a.e.update(s.indexBuffer,t),a.e.update(s.normalBuffer,r),a.e.update(s.groupBuffer,n),s}(e,t,r,i,o,c,l):function(e,t,r,i,o,c){var l,d=Object(s.g)(),f=-1,p=-1,h={kind:"mesh",vertexCount:o,triangleCount:c,vertexBuffer:a.e.create(e),indexBuffer:a.e.create(t),normalBuffer:a.e.create(r),groupBuffer:a.e.create(i),get boundingSphere(){var e=n(h);if(e!==f){var t=Object(m.a)(h.vertexBuffer.ref.value,h.vertexCount,1);s.g.copy(d,t),f=e}return d},get groupMapping(){return h.groupBuffer.ref.version!==p&&(l=Object(u.c)(h.groupBuffer.ref.value,h.vertexCount),p=h.groupBuffer.ref.version),l},setBoundingSphere:function(e){s.g.copy(d,e),f=n(h)}};return h}(e,t,r,i,o,c)}function r(e){return t(e?e.vertexBuffer.ref.value:new Float32Array(0),e?e.indexBuffer.ref.value:new Uint32Array(0),e?e.normalBuffer.ref.value:new Float32Array(0),e?e.groupBuffer.ref.value:new Float32Array(0),0,0,e)}function n(e){return Object(f.l)([e.vertexCount,e.triangleCount,e.vertexBuffer.ref.version,e.indexBuffer.ref.version,e.normalBuffer.ref.version,e.groupBuffer.ref.version])}e.create=t,e.createEmpty=r,e.computeNormals=function(e){var 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0:r.ignoreFilter)||this.filter.includeCategory(e.name)){var n=b(e,t),i=n.instance,a=n.rowCount,o=n.source;if(a){for(var s={name:"_"+e.name,columns:[],rowCount:a},u=0,c=v(i);u<c.length;u++){var l=c[u];if(this.filter.includeField(e.name,l.name)){var d=this.formatter.getFormat(e.name,l.name);s.columns.push(A(e.name,l,o,a,d,this.binaryEncodingProvider,this.autoClassify))}}s.columns.length&&this.dataBlocks[this.dataBlocks.length-1].categories.push(s)}}},e.prototype.encode=function(){this.encodedData||(this.encodedData=C(this.data),this.data=null,this.dataBlocks=null)},e.prototype.writeTo=function(e){e.writeBinary(this.encodedData)},e.prototype.getData=function(){return this.encode(),this.encodedData},e.prototype.getSize=function(){return this.encodedData.length},e}();function A(e,t,r,n,i,a,o){var s=function(e,t,r,n){for(var i=0===e.type,a=new t(r),o=new Uint8Array(r),s=e.valueKind,u=e.value,c=!0,l=0,d=0;d<n.length;d++)for(var f=n[d].data,p=n[d].keys();p.hasNext;){var m=p.move(),h=s?s(m,f):0;0!==h?(o[l]=h,i&&(a[l]=""),c=!1):(o[l]=0,a[l]=u(m,f,l)),l++}return{array:a,allPresent:c,mask:o}}(t,function(e,t){return t&&t.typedArray?t.typedArray:e.defaultFormat&&e.defaultFormat.typedArray?e.defaultFormat.typedArray:0===e.type?Array:1===e.type?Int32Array:Float64Array}(t,i),n,r),u=s.array,c=s.allPresent,d=s.mask,f=function(e,t,r,n){return r&&r.encoder?r.encoder:t.defaultFormat&&t.defaultFormat.encoder?t.defaultFormat.encoder:n?n.get(e,t.name):void 0}(e,t,i,a);f||(o?f=function(e,t){return 0===e?l.a.by(l.b.stringArray):1===e?Object(P.b)(t):Object(P.a)(t)}(t.type,u):f=0===t.type?l.a.by(l.b.stringArray):l.a.by(l.b.byteArray));var p=f.encode(u),m=void 0;if(!c){var h=l.a.by(l.b.runLength).and(l.b.byteArray).encode(d);m=h.data.length<d.length?h:l.a.by(l.b.byteArray).encode(d)}return{name:t.name,data:p,mask:m}}!function(e){e.Encoder=o,e.Category=i,e.Field=n,e.Encoding=l.b,e.createEncoder=function(e){var t=e||{},r=t.binary,n=void 0!==r&&r,i=t.encoderName;return n?new E(void 0===i?"mol*":i,e?e.binaryEncodingPovider:void 0,!!e&&!!e.binaryAutoClassifyEncoding):new y},e.fields=function(){return e.Field.build()};var t=e.Encoding;function r(e){var r=e.precision;if(void 0!==r){var n=Math.pow(10,r),i=t.by(t.fixedPoint(n));switch(e.encoding){case"pack":return i.and(t.integerPacking);case"rle":return i.and(t.runLength).and(t.integerPacking);case"delta":return i.and(t.delta).and(t.integerPacking);case"delta-rle":return i.and(t.delta).and(t.runLength).and(t.integerPacking)}}else switch(e.encoding){case"pack":return t.by(t.integerPacking);case"rle":return t.by(t.runLength).and(t.integerPacking);case"delta":return t.by(t.delta).and(t.integerPacking);case"delta-rle":return t.by(t.delta).and(t.runLength).and(t.integerPacking)}throw new Error("cannot be reached")}e.Encodings={deltaRLE:t.by(t.delta).and(t.runLength).and(t.integerPacking),fixedPoint2:t.by(t.fixedPoint(100)).and(t.delta).and(t.integerPacking),fixedPoint3:t.by(t.fixedPoint(1e3)).and(t.delta).and(t.integerPacking)},e.categoryInstance=function(e,t){return{fields:e,source:[t]}},e.createEncodingProviderFromCifFrame=function(e){return{get:function(t,r){var n=e.categories[t];if(n){var i=n.getField(r);return i&&i.binaryEncoding?l.a.fromEncoding(i.binaryEncoding):void 0}}}},e.createEncodingProviderFromJsonConfig=function(e){return{get:function(t,n){for(var i=0;i<e.length;i++){var a=e[i];if(a.categoryName===t&&a.columnName===n)return r(a)}}}}}(j||(j={}))},function(e,t,r){"use strict";r.d(t,"g",(function(){return f})),r.d(t,"f",(function(){return p})),r.d(t,"h",(function(){return m})),r.d(t,"a",(function(){return h})),r.d(t,"i",(function(){return g})),r.d(t,"d",(function(){return v})),r.d(t,"e",(function(){return b})),r.d(t,"b",(function(){return y})),r.d(t,"c",(function(){return _})),r.d(t,"j",(function(){return S}));var n=r(99),i=r(60),a=Object(n.a)(),o={apply_fog:"\nfloat viewZ = depthToViewZ(uIsOrtho, fragmentDepth, uNear, uFar);\nfloat fogFactor = smoothstep(uFogNear, uFogFar, abs(viewZ));\nfloat fogAlpha = (1.0 - fogFactor) * gl_FragColor.a;\nfloat preFogAlpha = gl_FragColor.a;\nif (!uTransparentBackground) {\n    if (gl_FragColor.a < 1.0) {\n        // transparent objects are blended with background color\n        gl_FragColor.a = fogAlpha;\n    } else {\n        // mix opaque objects with background color\n        gl_FragColor.rgb = mix(gl_FragColor.rgb, uFogColor, fogFactor);\n    }\n} else {\n    // pre-multiplied alpha expected for transparent background\n    gl_FragColor.rgb *= fogAlpha;\n    gl_FragColor.a = fogAlpha;\n}\n",apply_interior_color:"\nif (interior) {\n    if (uInteriorColorFlag) {\n        gl_FragColor.rgb = uInteriorColor;\n    } else {\n        gl_FragColor.rgb *= 1.0 - uInteriorDarkening;\n    }\n}\n",apply_light_color:"\n// inputs\n// - vec4 material\n// - vec3 vViewPosition\n// - vec3 normal\n// - float uMetalness\n// - float uRoughness\n// - float uReflectivity\n// - float uLightIntensity\n// - float uAmbientIntensity\n\n// outputs\n// - sets gl_FragColor\n\nvec4 color = material;\n\nReflectedLight reflectedLight = ReflectedLight(vec3(0.0), vec3(0.0), vec3(0.0));\n\nPhysicalMaterial physicalMaterial;\nphysicalMaterial.diffuseColor = color.rgb * (1.0 - uMetalness);\nphysicalMaterial.specularRoughness = clamp(uRoughness, 0.04, 1.0);\nphysicalMaterial.specularColor = mix(vec3(0.16 * pow2(uReflectivity)), color.rgb, uMetalness);\n\nGeometricContext geometry;\ngeometry.position = -vViewPosition;\ngeometry.normal = normal;\ngeometry.viewDir = normalize(vViewPosition);\n\nIncidentLight directLight;\ndirectLight.direction = vec3(0.0, 0.0, -1.0);\ndirectLight.color = vec3(uLightIntensity);\n\nRE_Direct_Physical(directLight, geometry, physicalMaterial, reflectedLight);\n\nvec3 irradiance = vec3(uAmbientIntensity) * PI;\nRE_IndirectDiffuse_Physical(irradiance, geometry, physicalMaterial, reflectedLight);\n\nvec3 outgoingLight = reflectedLight.directDiffuse + reflectedLight.indirectDiffuse + reflectedLight.directSpecular;\n\ngl_FragColor = vec4(outgoingLight, color.a);\n\n#ifdef dXrayShaded\n    gl_FragColor.a *= 1.0 - pow(abs(dot(normal, vec3(0, 0, 1))), uXrayEdgeFalloff);\n#endif\n",apply_marker_color:"\nfloat marker = floor(vMarker * 255.0 + 0.5); // rounding required to work on some cards on win\nif (marker > 0.1) {\n    if (intMod(marker, 2.0) > 0.1) {\n        gl_FragColor.rgb = mix(uHighlightColor, gl_FragColor.rgb, 0.3);\n        gl_FragColor.a = max(0.02, gl_FragColor.a); // for direct-volume rendering\n    } else {\n        gl_FragColor.rgb = mix(uSelectColor, gl_FragColor.rgb, 0.3);\n    }\n}\n",assign_clipping_varying:"\n#if dClipObjectCount != 0 && defined(dClipping)\n    vClipping = readFromTexture(tClipping, aInstance * float(uGroupCount) + group, uClippingTexDim).a;\n#endif\n",assign_color_varying:"\n#if defined(dRenderVariant_color)\n    #if defined(dColorType_attribute)\n        vColor.rgb = aColor;\n    #elif defined(dColorType_instance)\n        vColor.rgb = readFromTexture(tColor, aInstance, uColorTexDim).rgb;\n    #elif defined(dColorType_group)\n        vColor.rgb = readFromTexture(tColor, group, uColorTexDim).rgb;\n    #elif defined(dColorType_groupInstance)\n        vColor.rgb = readFromTexture(tColor, aInstance * float(uGroupCount) + group, uColorTexDim).rgb;\n    #elif defined(dColorType_vertex)\n        vColor.rgb = readFromTexture(tColor, VertexID, uColorTexDim).rgb;\n    #elif defined(dColorType_vertexInstance)\n        vColor.rgb = readFromTexture(tColor, int(aInstance) * uVertexCount + VertexID, uColorTexDim).rgb;\n    #endif\n\n    #ifdef dOverpaint\n        vOverpaint = readFromTexture(tOverpaint, aInstance * float(uGroupCount) + group, uOverpaintTexDim);\n    #endif\n#elif defined(dRenderVariant_pick)\n    #if defined(dRenderVariant_pickObject)\n        vColor = vec4(encodeFloatRGB(float(uObjectId)), 1.0);\n    #elif defined(dRenderVariant_pickInstance)\n        vColor = vec4(encodeFloatRGB(aInstance), 1.0);\n    #elif defined(dRenderVariant_pickGroup)\n        vColor = vec4(encodeFloatRGB(group), 1.0);\n    #endif\n#endif\n\n#ifdef dTransparency\n    vGroup = group;\n    vTransparency = readFromTexture(tTransparency, aInstance * float(uGroupCount) + group, uTransparencyTexDim).a;\n#endif\n",assign_group:"\n#ifdef dGeoTexture\n    float group = decodeFloatRGB(readFromTexture(tGroup, VertexID, uGeoTexDim).rgb);\n#else\n    float group = aGroup;\n#endif\n",assign_marker_varying:"\nvMarker = readFromTexture(tMarker, aInstance * float(uGroupCount) + group, uMarkerTexDim).a;\n",assign_material_color:"\n#if defined(dRenderVariant_color)\n    #if defined(dColorType_uniform)\n        vec4 material = vec4(uColor, uAlpha);\n    #elif defined(dColorType_varying)\n        vec4 material = vec4(vColor.rgb, uAlpha);\n    #endif\n\n    // mix material with overpaint\n    #if defined(dOverpaint)\n        material.rgb = mix(material.rgb, vOverpaint.rgb, vOverpaint.a);\n    #endif\n#elif defined(dRenderVariant_pick)\n    vec4 material = vColor;\n#elif defined(dRenderVariant_depth)\n    #ifdef enabledFragDepth\n        vec4 material = packDepthToRGBA(gl_FragDepthEXT);\n    #else\n        vec4 material = packDepthToRGBA(gl_FragCoord.z);\n    #endif\n#endif\n\n// apply screendoor transparency\n#if defined(dTransparency)\n    float ta = 1.0 - vTransparency;\n\n    #if defined(dRenderVariant_pick)\n        if (ta < uPickingAlphaThreshold)\n            discard; // ignore so the element below can be picked\n    #else\n        #if defined(dRenderVariant_colorBlended)\n            float at = 0.0;\n\n            // shift by view-offset during multi-sample rendering to allow for blending\n            vec2 coord = gl_FragCoord.xy + uViewOffset * 0.25;\n\n            const mat4 thresholdMatrix = mat4(\n                1.0 / 17.0,  9.0 / 17.0,  3.0 / 17.0, 11.0 / 17.0,\n                13.0 / 17.0,  5.0 / 17.0, 15.0 / 17.0,  7.0 / 17.0,\n                4.0 / 17.0, 12.0 / 17.0,  2.0 / 17.0, 10.0 / 17.0,\n                16.0 / 17.0,  8.0 / 17.0, 14.0 / 17.0,  6.0 / 17.0\n            );\n            int ci = int(intMod(coord.x, 4.0));\n            int ri = int(intMod(coord.y, 4.0));\n            #if __VERSION__ == 100\n                vec4 i = vec4(float(ci * 4 + ri));\n                vec4 v = thresholdMatrix[0] * vec4(equal(i, vec4(0.0, 1.0, 2.0, 3.0))) +\n                    thresholdMatrix[1] * vec4(equal(i, vec4(4.0, 5.0, 6.0, 7.0))) +\n                    thresholdMatrix[2] * vec4(equal(i, vec4(8.0, 9.0, 10.0, 11.0))) +\n                    thresholdMatrix[3] * vec4(equal(i, vec4(12.0, 13.0, 14.0, 15.0)));\n                at = v.x + v.y + v.z + v.w;\n            #else\n                at = thresholdMatrix[ci][ri];\n            #endif\n\n            if (ta < 0.99 && (ta < 0.01 || ta < at)) {\n                discard;\n            }\n        #elif defined(dRenderVariant_colorWboit)\n            material.a *= ta;\n        #endif\n    #endif\n#endif\n",assign_position:"\nmat4 model = uModel * aTransform;\nmat4 modelView = uView * model;\n#ifdef dGeoTexture\n    vec3 position = readFromTexture(tPosition, VertexID, uGeoTexDim).xyz;\n#else\n    vec3 position = aPosition;\n#endif\nvec4 position4 = vec4(position, 1.0);\nvModelPosition = (model * position4).xyz; // for clipping in frag shader\nvec4 mvPosition = modelView * position4;\nvViewPosition = mvPosition.xyz;\ngl_Position = uProjection * mvPosition;\n",assign_size:"\n#if defined(dSizeType_uniform)\n    float size = uSize;\n#elif defined(dSizeType_attribute)\n    float size = aSize;\n#elif defined(dSizeType_instance)\n    float size = decodeFloatRGB(readFromTexture(tSize, aInstance, uSizeTexDim).rgb);\n#elif defined(dSizeType_group)\n    float size = decodeFloatRGB(readFromTexture(tSize, group, uSizeTexDim).rgb);\n#elif defined(dSizeType_groupInstance)\n    float size = decodeFloatRGB(readFromTexture(tSize, aInstance * float(uGroupCount) + group, uSizeTexDim).rgb);\n#endif\n\n#if defined(dSizeType_instance) || defined(dSizeType_group) || defined(dSizeType_groupInstance)\n    size /= 100.0; // NOTE factor also set in TypeScript\n#endif\n\nsize *= uSizeFactor;\n",check_picking_alpha:"\nfloat viewZ = depthToViewZ(uIsOrtho, fragmentDepth, uNear, uFar);\nfloat fogFactor = smoothstep(uFogNear, uFogFar, abs(viewZ));\nfloat alpha = (1.0 - fogFactor) * uAlpha;\nif (uAlpha < uPickingAlphaThreshold || alpha < 0.1)\n    discard; // ignore so the element below can be picked\n",clip_instance:"\n#if defined(dClipVariant_instance) && dClipObjectCount != 0\n    int flag = 0;\n    #if defined(dClipping)\n        flag = int(floor(vClipping * 255.0 + 0.5));\n    #endif\n\n    vec4 mCenter = uModel * aTransform * vec4(uInvariantBoundingSphere.xyz, 1.0);\n    if (clipTest(vec4(mCenter.xyz, uInvariantBoundingSphere.w), flag))\n        // move out of [ -w, +w ] to 'discard' in vert shader\n        gl_Position.z = 2.0 * gl_Position.w;\n#endif\n",clip_pixel:"\n#if defined(dClipVariant_pixel) && dClipObjectCount != 0\n    #if defined(dClipping)\n        int clippingFlag = int(floor(vClipping * 255.0 + 0.5));\n    #else\n        int clippingFlag = 0;\n    #endif\n\n    if (clipTest(vec4(vModelPosition, 0.0), clippingFlag))\n        discard;\n#endif\n",color_frag_params:"\n#if defined(dRenderVariant_color)\n    #if defined(dColorType_uniform)\n        uniform vec3 uColor;\n    #elif defined(dColorType_varying)\n        varying vec4 vColor;\n    #endif\n\n    #ifdef dOverpaint\n        varying vec4 vOverpaint;\n    #endif\n#elif defined(dRenderVariant_pick)\n    #if __VERSION__ == 100\n        varying vec4 vColor;\n    #else\n        flat in vec4 vColor;\n    #endif\n#endif\n\n#ifdef dTransparency\n    varying float vGroup;\n    varying float vTransparency;\n#endif\n",color_vert_params:"\n#if defined(dRenderVariant_color)\n    #if defined(dColorType_uniform)\n        uniform vec3 uColor;\n    #elif defined(dColorType_attribute)\n        varying vec4 vColor;\n        attribute vec3 aColor;\n    #elif defined(dColorType_texture)\n        varying vec4 vColor;\n        uniform vec2 uColorTexDim;\n        uniform sampler2D tColor;\n    #endif\n\n    #ifdef dOverpaint\n        varying vec4 vOverpaint;\n        uniform vec2 uOverpaintTexDim;\n        uniform sampler2D tOverpaint;\n    #endif\n#elif defined(dRenderVariant_pick)\n    #if __VERSION__ == 100\n        varying vec4 vColor;\n    #else\n        flat out vec4 vColor;\n    #endif\n#endif\n\n#ifdef dTransparency\n    varying float vGroup;\n    varying float vTransparency;\n    uniform vec2 uTransparencyTexDim;\n    uniform sampler2D tTransparency;\n#endif\n",common_clip:"\n#if dClipObjectCount != 0\n    vec3 quaternionTransform(vec4 q, vec3 v) {\n        vec3 t = 2.0 * cross(q.xyz, v);\n        return v + q.w * t + cross(q.xyz, t);\n    }\n\n    vec4 computePlane(vec3 normal, vec3 inPoint) {\n        return vec4(normalize(normal), -dot(normal, inPoint));\n    }\n\n    float planeSD(vec4 plane, vec3 center) {\n        return -dot(plane.xyz, center - plane.xyz * -plane.w);\n    }\n\n    float sphereSD(vec3 position, vec4 rotation, vec3 size, vec3 center) {\n        return (\n            length(quaternionTransform(vec4(-rotation.x, -rotation.y, -rotation.z, rotation.w), center - position) / size) - 1.0\n        ) * min(min(size.x, size.y), size.z);\n    }\n\n    float cubeSD(vec3 position, vec4 rotation, vec3 size, vec3 center) {\n        vec3 d = abs(quaternionTransform(vec4(-rotation.x, -rotation.y, -rotation.z, rotation.w), center - position)) - size;\n        return min(max(d.x, max(d.y, d.z)), 0.0) + length(max(d, 0.0));\n    }\n\n    float cylinderSD(vec3 position, vec4 rotation, vec3 size, vec3 center) {\n        vec3 t = quaternionTransform(vec4(-rotation.x, -rotation.y, -rotation.z, rotation.w), center - position);\n\n        vec2 d = abs(vec2(length(t.xz), t.y)) - size.xy;\n        return min(max(d.x, d.y), 0.0) + length(max(d, 0.0));\n    }\n\n    float infiniteConeSD(vec3 position, vec4 rotation, vec3 size, vec3 center) {\n        vec3 t = quaternionTransform(vec4(-rotation.x, -rotation.y, -rotation.z, rotation.w), center - position);\n\n        float q = length(t.xy);\n        return dot(size.xy, vec2(q, t.z));\n    }\n\n    float getSignedDistance(vec3 center, int type, vec3 position, vec4 rotation, vec3 scale) {\n        if (type == 1) {\n            vec3 normal = quaternionTransform(rotation, vec3(0.0, 1.0, 0.0));\n            vec4 plane = computePlane(normal, position);\n            return planeSD(plane, center);\n        } else if (type == 2) {\n            return sphereSD(position, rotation, scale * 0.5, center);\n        } else if (type == 3) {\n            return cubeSD(position, rotation, scale * 0.5, center);\n        } else if (type == 4) {\n            return cylinderSD(position, rotation, scale * 0.5, center);\n        } else if (type == 5) {\n            return infiniteConeSD(position, rotation, scale * 0.5, center);\n        } else {\n            return 0.1;\n        }\n    }\n\n    #if __VERSION__ == 100\n        // 8-bit\n        int bitwiseAnd(int a, int b) {\n            int d = 128;\n            int result = 0;\n            for (int i = 0; i < 8; ++i) {\n                if (d <= 0) break;\n                if (a >= d && b >= d) result += d;\n                if (a >= d) a -= d;\n                if (b >= d) b -= d;\n                d /= 2;\n            }\n            return result;\n        }\n\n        bool hasBit(int mask, int bit) {\n            return bitwiseAnd(mask, bit) == 0;\n        }\n    #else\n        bool hasBit(int mask, int bit) {\n            return (mask & bit) == 0;\n        }\n    #endif\n\n    // flag is a bit-flag for clip-objects to ignore (note, object ids start at 1 not 0)\n    bool clipTest(vec4 sphere, int flag) {\n        for (int i = 0; i < dClipObjectCount; ++i) {\n            if (flag == 0 || hasBit(flag, i + 1)) {\n                // TODO take sphere radius into account?\n                bool test = getSignedDistance(sphere.xyz, uClipObjectType[i], uClipObjectPosition[i], uClipObjectRotation[i], uClipObjectScale[i]) <= 0.0;\n                if ((!uClipObjectInvert[i] && test) || (uClipObjectInvert[i] && !test)) {\n                    return true;\n                }\n            }\n        }\n        return false;\n    }\n#endif\n",common_frag_params:"\nuniform int uObjectId;\nuniform int uInstanceCount;\nuniform int uGroupCount;\n\n#if dClipObjectCount != 0\n    uniform int uClipObjectType[dClipObjectCount];\n    uniform bool uClipObjectInvert[dClipObjectCount];\n    uniform vec3 uClipObjectPosition[dClipObjectCount];\n    uniform vec4 uClipObjectRotation[dClipObjectCount];\n    uniform vec3 uClipObjectScale[dClipObjectCount];\n\n    #if defined(dClipping)\n        #if __VERSION__ == 100\n            varying float vClipping;\n        #else\n            flat in float vClipping;\n        #endif\n    #endif\n#endif\n\nuniform vec3 uHighlightColor;\nuniform vec3 uSelectColor;\n#if __VERSION__ == 100\n    varying float vMarker;\n#else\n    flat in float vMarker;\n#endif\n\nvarying vec3 vModelPosition;\nvarying vec3 vViewPosition;\n\nuniform vec2 uViewOffset;\n\nuniform float uNear;\nuniform float uFar;\nuniform float uIsOrtho;\n\nuniform float uFogNear;\nuniform float uFogFar;\nuniform vec3 uFogColor;\n\nuniform float uAlpha;\nuniform float uPickingAlphaThreshold;\nuniform bool uTransparentBackground;\n\nuniform float uInteriorDarkening;\nuniform bool uInteriorColorFlag;\nuniform vec3 uInteriorColor;\nbool interior;\n\nuniform float uXrayEdgeFalloff;\n\nuniform mat4 uProjection;\n",common_vert_params:"\nuniform mat4 uProjection, uModel, uView;\nuniform vec3 uCameraPosition;\n\nuniform int uObjectId;\nuniform int uVertexCount;\nuniform int uInstanceCount;\nuniform int uGroupCount;\nuniform vec4 uInvariantBoundingSphere;\n\n#if dClipObjectCount != 0\n    uniform int uClipObjectType[dClipObjectCount];\n    uniform bool uClipObjectInvert[dClipObjectCount];\n    uniform vec3 uClipObjectPosition[dClipObjectCount];\n    uniform vec4 uClipObjectRotation[dClipObjectCount];\n    uniform vec3 uClipObjectScale[dClipObjectCount];\n\n    #if defined(dClipping)\n        uniform vec2 uClippingTexDim;\n        uniform sampler2D tClipping;\n        #if __VERSION__ == 100\n            varying float vClipping;\n        #else\n            flat out float vClipping;\n        #endif\n    #endif\n#endif\n\nuniform vec2 uMarkerTexDim;\nuniform sampler2D tMarker;\n#if __VERSION__ == 100\n    varying float vMarker;\n#else\n    flat out float vMarker;\n#endif\n\nvarying vec3 vModelPosition;\nvarying vec3 vViewPosition;\n\n#if __VERSION__ == 100\n    attribute float aVertex;\n    #define VertexID int(aVertex)\n#else\n    // not using gl_VertexID but aVertex to ensure there is an active attribute with divisor 0\n    // since FF 85 this is not needed anymore but lets keep it for backwards compatibility\n    // https://bugzilla.mozilla.org/show_bug.cgi?id=1679693\n    // see also note in src/mol-gl/webgl/render-item.ts\n    attribute float aVertex;\n    #define VertexID int(aVertex)\n    // #define VertexID gl_VertexID\n#endif\n",common:"\n// TODO find a better place for these convenience defines\n\n#if defined(dRenderVariant_colorBlended) || defined(dRenderVariant_colorWboit)\n    #define dRenderVariant_color\n#endif\n\n#if defined(dRenderVariant_pickObject) || defined(dRenderVariant_pickInstance) || defined(dRenderVariant_pickGroup)\n    #define dRenderVariant_pick\n#endif\n\n#if defined(dColorType_instance) || defined(dColorType_group) || defined(dColorType_groupInstance) || defined(dColorType_vertex) || defined(dColorType_vertexInstance)\n    #define dColorType_texture\n#endif\n\n#if defined(dColorType_attribute) || defined(dColorType_texture)\n    #define dColorType_varying\n#endif\n\n//\n\n#define PI 3.14159265\n#define RECIPROCAL_PI 0.31830988618\n#define EPSILON 1e-6\n\n#define saturate(a) clamp(a, 0.0, 1.0)\n\nfloat intDiv(const in float a, const in float b) { return float(int(a) / int(b)); }\nvec2 ivec2Div(const in vec2 a, const in vec2 b) { return vec2(ivec2(a) / ivec2(b)); }\nfloat intMod(const in float a, const in float b) { return a - b * float(int(a) / int(b)); }\nint imod(const in int a, const in int b) { return a - b * (a / b); }\n\nfloat pow2(const in float x) { return x * x; }\n\nconst float maxFloat = 10000.0; // NOTE constant also set in TypeScript\nconst float floatLogFactor = 9.210440366976517; // log(maxFloat + 1.0);\nfloat encodeFloatLog(const in float value) { return log(value + 1.0) / floatLogFactor; }\nfloat decodeFloatLog(const in float value) { return exp(value * floatLogFactor) - 1.0; }\n\nvec3 encodeFloatRGB(in float value) {\n    value = clamp(value, 0.0, 16777216.0 - 1.0) + 1.0;\n    vec3 c = vec3(0.0);\n    c.b = mod(value, 256.0);\n    value = floor(value / 256.0);\n    c.g = mod(value, 256.0);\n    value = floor(value / 256.0);\n    c.r = mod(value, 256.0);\n    return c / 255.0;\n}\nfloat decodeFloatRGB(const in vec3 rgb) {\n    return (rgb.r * 256.0 * 256.0 * 255.0 + rgb.g * 256.0 * 255.0 + rgb.b * 255.0) - 1.0;\n}\n\nvec2 packUnitIntervalToRG(const in float v) {\n    vec2 enc;\n    enc.xy = vec2(fract(v * 256.0), v);\n    enc.y -= enc.x * (1.0 / 256.0);\n    enc.xy *=  256.0 / 255.0;\n\n    return enc;\n}\n\nfloat unpackRGToUnitInterval(const in vec2 enc) {\n    return dot(enc, vec2(255.0 / (256.0 * 256.0), 255.0 / 256.0));\n}\n\nvec3 screenSpaceToViewSpace(const in vec3 ssPos, const in mat4 invProjection) {\n    vec4 p = vec4(ssPos * 2.0 - 1.0, 1.0);\n    p = invProjection * p;\n    return p.xyz / p.w;\n}\n\nconst float PackUpscale = 256.0 / 255.0; // fraction -> 0..1 (including 1)\nconst float UnpackDownscale = 255.0 / 256.0; // 0..1 -> fraction (excluding 1)\nconst vec3 PackFactors = vec3(256.0 * 256.0 * 256.0, 256.0 * 256.0,  256.0);\nconst vec4 UnpackFactors = UnpackDownscale / vec4(PackFactors, 1.0);\nconst float ShiftRight8 = 1.0 / 256.0;\n\nvec4 packDepthToRGBA(const in float v) {\n    vec4 r = vec4(fract(v * PackFactors), v);\n    r.yzw -= r.xyz * ShiftRight8; // tidy overflow\n    return r * PackUpscale;\n}\nfloat unpackRGBAToDepth(const in vec4 v) {\n    return dot(v, UnpackFactors);\n}\n\nvec4 sRGBToLinear(const in vec4 c) {\n    return vec4(mix(pow(c.rgb * 0.9478672986 + vec3(0.0521327014), vec3(2.4)), c.rgb * 0.0773993808, vec3(lessThanEqual(c.rgb, vec3(0.04045)))), c.a);\n}\nvec4 linearTosRGB(const in vec4 c) {\n    return vec4(mix(pow(c.rgb, vec3(0.41666)) * 1.055 - vec3(0.055), c.rgb * 12.92, vec3(lessThanEqual(c.rgb, vec3(0.0031308)))), c.a);\n}\n\nfloat linearizeDepth(const in float depth, const in float near, const in float far) {\n    return (2.0 * near) / (far + near - depth * (far - near));\n}\n\nfloat perspectiveDepthToViewZ(const in float invClipZ, const in float near, const in float far) {\n    return (near * far) / ((far - near) * invClipZ - far);\n}\n\nfloat orthographicDepthToViewZ(const in float linearClipZ, const in float near, const in float far) {\n    return linearClipZ * (near - far) - near;\n}\n\nfloat depthToViewZ(const in float isOrtho, const in float linearClipZ, const in float near, const in float far) {\n    return isOrtho == 1.0 ? orthographicDepthToViewZ(linearClipZ, near, far) : perspectiveDepthToViewZ(linearClipZ, near, far);\n}\n\n#if __VERSION__ == 100\n    // transpose\n\n    float transpose(const in float m) {\n        return m;\n    }\n\n    mat2 transpose2(const in mat2 m) {\n        return mat2(\n            m[0][0], m[1][0],\n            m[0][1], m[1][1]\n        );\n    }\n\n    mat3 transpose3(const in mat3 m) {\n        return mat3(\n            m[0][0], m[1][0], m[2][0],\n            m[0][1], m[1][1], m[2][1],\n            m[0][2], m[1][2], m[2][2]\n        );\n    }\n\n    mat4 transpose4(const in mat4 m) {\n        return mat4(\n            m[0][0], m[1][0], m[2][0], m[3][0],\n            m[0][1], m[1][1], m[2][1], m[3][1],\n            m[0][2], m[1][2], m[2][2], m[3][2],\n            m[0][3], m[1][3], m[2][3], m[3][3]\n        );\n    }\n\n    // inverse\n\n    float inverse(const in float m) {\n        return 1.0 / m;\n    }\n\n    mat2 inverse2(const in mat2 m) {\n        return mat2(m[1][1],-m[0][1],\n                -m[1][0], m[0][0]) / (m[0][0]*m[1][1] - m[0][1]*m[1][0]);\n    }\n\n    mat3 inverse3(const in mat3 m) {\n        float a00 = m[0][0], a01 = m[0][1], a02 = m[0][2];\n        float a10 = m[1][0], a11 = m[1][1], a12 = m[1][2];\n        float a20 = m[2][0], a21 = m[2][1], a22 = m[2][2];\n\n        float b01 = a22 * a11 - a12 * a21;\n        float b11 = -a22 * a10 + a12 * a20;\n        float b21 = a21 * a10 - a11 * a20;\n\n        float det = a00 * b01 + a01 * b11 + a02 * b21;\n\n        return mat3(b01, (-a22 * a01 + a02 * a21), (a12 * a01 - a02 * a11),\n                    b11, (a22 * a00 - a02 * a20), (-a12 * a00 + a02 * a10),\n                    b21, (-a21 * a00 + a01 * a20), (a11 * a00 - a01 * a10)) / det;\n    }\n\n    mat4 inverse4(const in mat4 m) {\n        float\n            a00 = m[0][0], a01 = m[0][1], a02 = m[0][2], a03 = m[0][3],\n            a10 = m[1][0], a11 = m[1][1], a12 = m[1][2], a13 = m[1][3],\n            a20 = m[2][0], a21 = m[2][1], a22 = m[2][2], a23 = m[2][3],\n            a30 = m[3][0], a31 = m[3][1], a32 = m[3][2], a33 = m[3][3],\n\n            b00 = a00 * a11 - a01 * a10,\n            b01 = a00 * a12 - a02 * a10,\n            b02 = a00 * a13 - a03 * a10,\n            b03 = a01 * a12 - a02 * a11,\n            b04 = a01 * a13 - a03 * a11,\n            b05 = a02 * a13 - a03 * a12,\n            b06 = a20 * a31 - a21 * a30,\n            b07 = a20 * a32 - a22 * a30,\n            b08 = a20 * a33 - a23 * a30,\n            b09 = a21 * a32 - a22 * a31,\n            b10 = a21 * a33 - a23 * a31,\n            b11 = a22 * a33 - a23 * a32,\n\n            det = b00 * b11 - b01 * b10 + b02 * b09 + b03 * b08 - b04 * b07 + b05 * b06;\n\n        return mat4(\n            a11 * b11 - a12 * b10 + a13 * b09,\n            a02 * b10 - a01 * b11 - a03 * b09,\n            a31 * b05 - a32 * b04 + a33 * b03,\n            a22 * b04 - a21 * b05 - a23 * b03,\n            a12 * b08 - a10 * b11 - a13 * b07,\n            a00 * b11 - a02 * b08 + a03 * b07,\n            a32 * b02 - a30 * b05 - a33 * b01,\n            a20 * b05 - a22 * b02 + a23 * b01,\n            a10 * b10 - a11 * b08 + a13 * b06,\n            a01 * b08 - a00 * b10 - a03 * b06,\n            a30 * b04 - a31 * b02 + a33 * b00,\n            a21 * b02 - a20 * b04 - a23 * b00,\n            a11 * b07 - a10 * b09 - a12 * b06,\n            a00 * b09 - a01 * b07 + a02 * b06,\n            a31 * b01 - a30 * b03 - a32 * b00,\n            a20 * b03 - a21 * b01 + a22 * b00) / det;\n    }\n#else\n    #define transpose2(m) transpose(m)\n    #define transpose3(m) transpose(m)\n    #define transpose4(m) transpose(m)\n\n    #define inverse2(m) inverse(m)\n    #define inverse3(m) inverse(m)\n    #define inverse4(m) inverse(m)\n#endif\n",float_to_rgba:"\n    // floatToRgba adapted from https://github.com/equinor/glsl-float-to-rgba\n    // MIT License, Copyright (c) 2020 Equinor\n\n    float shiftRight (float v, float amt) {\n    v = floor(v) + 0.5;\n    return floor(v / exp2(amt));\n    }\n    float shiftLeft (float v, float amt) {\n        return floor(v * exp2(amt) + 0.5);\n    }\n    float maskLast (float v, float bits) {\n        return mod(v, shiftLeft(1.0, bits));\n    }\n    float extractBits (float num, float from, float to) {\n        from = floor(from + 0.5); to = floor(to + 0.5);\n        return maskLast(shiftRight(num, from), to - from);\n    }\n\n    vec4 floatToRgba(float texelFloat, bool littleEndian) {\n        if (texelFloat == 0.0) return vec4(0.0, 0.0, 0.0, 0.0);\n        float sign = texelFloat > 0.0 ? 0.0 : 1.0;\n        texelFloat = abs(texelFloat);\n        float exponent = floor(log2(texelFloat));\n        float biased_exponent = exponent + 127.0;\n        float fraction = ((texelFloat / exp2(exponent)) - 1.0) * 8388608.0;\n        float t = biased_exponent / 2.0;\n        float last_bit_of_biased_exponent = fract(t) * 2.0;\n        float remaining_bits_of_biased_exponent = floor(t);\n        float byte4 = extractBits(fraction, 0.0, 8.0) / 255.0;\n        float byte3 = extractBits(fraction, 8.0, 16.0) / 255.0;\n        float byte2 = (last_bit_of_biased_exponent * 128.0 + extractBits(fraction, 16.0, 23.0)) / 255.0;\n        float byte1 = (sign * 128.0 + remaining_bits_of_biased_exponent) / 255.0;\n        return (\n            littleEndian\n                ? vec4(byte4, byte3, byte2, byte1)\n                : vec4(byte1, byte2, byte3, byte4)\n        );\n    }\n",light_frag_params:"\nuniform float uLightIntensity;\nuniform float uAmbientIntensity;\nuniform float uReflectivity;\nuniform float uMetalness;\nuniform float uRoughness;\n\nstruct PhysicalMaterial {\n    vec3 diffuseColor;\n    float specularRoughness;\n    vec3 specularColor;\n};\n\nstruct IncidentLight {\n    vec3 color;\n    vec3 direction;\n};\n\nstruct ReflectedLight {\n    vec3 directDiffuse;\n    vec3 directSpecular;\n    vec3 indirectDiffuse;\n};\n\nstruct GeometricContext {\n    vec3 position;\n    vec3 normal;\n    vec3 viewDir;\n};\n\nvec3 F_Schlick(const in vec3 specularColor, const in float dotLH) {\n    // Original approximation by Christophe Schlick '94\n    // float fresnel = pow( 1.0 - dotLH, 5.0 );\n    // Optimized variant (presented by Epic at SIGGRAPH '13)\n    // https://cdn2.unrealengine.com/Resources/files/2013SiggraphPresentationsNotes-26915738.pdf\n    float fresnel = exp2((-5.55473 * dotLH - 6.98316) * dotLH);\n    return (1.0 - specularColor) * fresnel + specularColor;\n}\n\n// Moving Frostbite to Physically Based Rendering 3.0 - page 12, listing 2\n// https://seblagarde.files.wordpress.com/2015/07/course_notes_moving_frostbite_to_pbr_v32.pdf\nfloat G_GGX_SmithCorrelated(const in float alpha, const in float dotNL, const in float dotNV) {\n    float a2 = pow2(alpha);\n    // dotNL and dotNV are explicitly swapped. This is not a mistake.\n    float gv = dotNL * sqrt(a2 + (1.0 - a2) * pow2(dotNV));\n    float gl = dotNV * sqrt(a2 + (1.0 - a2) * pow2(dotNL));\n    return 0.5 / max(gv + gl, EPSILON);\n}\n\n// Microfacet Models for Refraction through Rough Surfaces - equation (33)\n// http://graphicrants.blogspot.com/2013/08/specular-brdf-reference.html\n// alpha is \"roughness squared\" in Disney’s reparameterization\nfloat D_GGX(const in float alpha, const in float dotNH) {\n    float a2 = pow2(alpha);\n    float denom = pow2(dotNH) * (a2 - 1.0) + 1.0; // avoid alpha = 0 with dotNH = 1\n    return RECIPROCAL_PI * a2 / pow2(denom);\n}\n\nvec3 BRDF_Diffuse_Lambert(const in vec3 diffuseColor) {\n    return RECIPROCAL_PI * diffuseColor;\n}\n\n// GGX Distribution, Schlick Fresnel, GGX-Smith Visibility\nvec3 BRDF_Specular_GGX(const in IncidentLight incidentLight, const in GeometricContext geometry, const in vec3 specularColor, const in float roughness) {\n    float alpha = pow2(roughness); // UE4's roughness\n    vec3 halfDir = normalize(incidentLight.direction + geometry.viewDir);\n\n    float dotNL = saturate(dot(geometry.normal, incidentLight.direction));\n    float dotNV = saturate(dot(geometry.normal, geometry.viewDir));\n    float dotNH = saturate(dot(geometry.normal, halfDir));\n    float dotLH = saturate(dot(incidentLight.direction, halfDir));\n\n    vec3 F = F_Schlick(specularColor, dotLH);\n    float G = G_GGX_SmithCorrelated(alpha, dotNL, dotNV);\n    float D = D_GGX(alpha, dotNH);\n    return F * (G * D);\n}\n\n// ref: https://www.unrealengine.com/blog/physically-based-shading-on-mobile - environmentBRDF for GGX on mobile\nvec3 BRDF_Specular_GGX_Environment(const in GeometricContext geometry, const in vec3 specularColor, const in float roughness) {\n    float dotNV = saturate(dot(geometry.normal, geometry.viewDir));\n    const vec4 c0 = vec4(-1, -0.0275, -0.572, 0.022);\n    const vec4 c1 = vec4(1, 0.0425, 1.04, -0.04);\n    vec4 r = roughness * c0 + c1;\n    float a004 = min(r.x * r.x, exp2(-9.28 * dotNV)) * r.x + r.y;\n    vec2 AB = vec2(-1.04, 1.04) * a004 + r.zw;\n    return specularColor * AB.x + AB.y;\n}\n\nvoid RE_Direct_Physical(const in IncidentLight directLight, const in GeometricContext geometry, const in PhysicalMaterial material, inout ReflectedLight reflectedLight) {\n    float dotNL = saturate(dot(geometry.normal, directLight.direction));\n    vec3 irradiance = dotNL * directLight.color;\n    irradiance *= PI; // punctual light\n\n    reflectedLight.directSpecular += irradiance * BRDF_Specular_GGX(directLight, geometry, material.specularColor, material.specularRoughness);\n    reflectedLight.directDiffuse += irradiance * BRDF_Diffuse_Lambert(material.diffuseColor);\n}\n\nvoid RE_IndirectDiffuse_Physical(const in vec3 irradiance, const in GeometricContext geometry, const in PhysicalMaterial material, inout ReflectedLight reflectedLight) {\n    reflectedLight.indirectDiffuse += irradiance * BRDF_Diffuse_Lambert(material.diffuseColor);\n}\n",matrix_scale:"\nfloat matrixScale(in mat4 m){\n    vec4 r = m[0];\n    return sqrt(r[0] * r[0] + r[1] * r[1] + r[2] * r[2]);\n}\n",normal_frag_params:"\nvarying vec3 vNormal;\n",read_from_texture:"\nvec4 readFromTexture(const in sampler2D tex, const in float i, const in vec2 dim) {\n    float x = intMod(i, dim.x);\n    float y = floor(intDiv(i, dim.x));\n    vec2 uv = (vec2(x, y) + 0.5) / dim;\n    return texture2D(tex, uv);\n}\n\nvec4 readFromTexture(const in sampler2D tex, const in int i, const in vec2 dim) {\n    int x = imod(i, int(dim.x));\n    int y = i / int(dim.x);\n    vec2 uv = (vec2(x, y) + 0.5) / dim;\n    return texture2D(tex, uv);\n}\n",rgba_to_float:'\n    // rgbaToFloat adapted from https://github.com/ihmeuw/glsl-rgba-to-float\n    // BSD 3-Clause License\n    //\n    // Copyright (c) 2019, Institute for Health Metrics and Evaluation All rights reserved.\n    // Redistribution and use in source and binary forms, with or without modification, are permitted provided that the following conditions are met:\n    //  - Redistributions of source code must retain the above copyright notice, this list of conditions and the following disclaimer.\n    //  - Redistributions in binary form must reproduce the above copyright notice, this list of conditions and the following disclaimer in the documentation and/or other materials provided with the distribution.\n    //  - Neither the name of the copyright holder nor the names of its contributors may be used to endorse or promote products derived from this software without specific prior written permission.\n    //\n    // THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND ANY EXPRESS OR IMPLIED WARRANTIES,\n    // INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED.\n    // IN NO EVENT SHALL THE COPYRIGHT HOLDER OR CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY,\n    // OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA,\n    // OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY,\n    // OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED\n    // OF THE POSSIBILITY OF SUCH DAMAGE.\n\n    ivec4 floatsToBytes(vec4 inputFloats, bool littleEndian) {\n        ivec4 bytes = ivec4(inputFloats * 255.0);\n        return (\n            littleEndian\n                ? bytes.abgr\n                : bytes\n        );\n    }\n\n    // Break the four bytes down into an array of 32 bits.\n    void bytesToBits(const in ivec4 bytes, out bool bits[32]) {\n        for (int channelIndex = 0; channelIndex < 4; ++channelIndex) {\n            float acc = float(bytes[channelIndex]);\n            for (int indexInByte = 7; indexInByte >= 0; --indexInByte) {\n                float powerOfTwo = exp2(float(indexInByte));\n                bool bit = acc >= powerOfTwo;\n                bits[channelIndex * 8 + (7 - indexInByte)] = bit;\n                acc = mod(acc, powerOfTwo);\n            }\n        }\n    }\n\n    // Compute the exponent of the 32-bit float.\n    float getExponent(bool bits[32]) {\n        const int startIndex = 1;\n        const int bitStringLength = 8;\n        const int endBeforeIndex = startIndex + bitStringLength;\n        float acc = 0.0;\n        int pow2 = bitStringLength - 1;\n        for (int bitIndex = startIndex; bitIndex < endBeforeIndex; ++bitIndex) {\n            acc += float(bits[bitIndex]) * exp2(float(pow2--));\n        }\n        return acc;\n    }\n\n    // Compute the mantissa of the 32-bit float.\n    float getMantissa(bool bits[32], bool subnormal) {\n        const int startIndex = 9;\n        const int bitStringLength = 23;\n        const int endBeforeIndex = startIndex + bitStringLength;\n        // Leading/implicit/hidden bit convention:\n        // If the number is not subnormal (with exponent 0), we add a leading 1 digit.\n        float acc = float(!subnormal) * exp2(float(bitStringLength));\n        int pow2 = bitStringLength - 1;\n        for (int bitIndex = startIndex; bitIndex < endBeforeIndex; ++bitIndex) {\n            acc += float(bits[bitIndex]) * exp2(float(pow2--));\n        }\n        return acc;\n    }\n\n    // Parse the float from its 32 bits.\n    float bitsToFloat(bool bits[32]) {\n        float signBit = float(bits[0]) * -2.0 + 1.0;\n        float exponent = getExponent(bits);\n        bool subnormal = abs(exponent - 0.0) < 0.01;\n        float mantissa = getMantissa(bits, subnormal);\n        float exponentBias = 127.0;\n        return signBit * mantissa * exp2(exponent - exponentBias - 23.0);\n    }\n\n    float rgbaToFloat(vec4 texelRGBA, bool littleEndian) {\n        ivec4 rgbaBytes = floatsToBytes(texelRGBA, littleEndian);\n        bool bits[32];\n        bytesToBits(rgbaBytes, bits);\n        return bitsToFloat(bits);\n    }\n',size_vert_params:"\n#if defined(dSizeType_uniform)\n    uniform float uSize;\n#elif defined(dSizeType_attribute)\n    attribute float aSize;\n#elif defined(dSizeType_instance) || defined(dSizeType_group) || defined(dSizeType_groupInstance)\n    uniform vec2 uSizeTexDim;\n    uniform sampler2D tSize;\n#endif\n\nuniform float uSizeFactor;\n",texture3d_from_1d_trilinear:"\nvec4 texture3dFrom1dTrilinear(const in sampler2D tex, const in vec3 pos, const in vec3 gridDim, const in vec2 texDim, const in float offset) {\n    float gdYZ = gridDim.z * gridDim.y;\n    float gdZ = gridDim.z;\n    vec3 p0 = floor(pos * gridDim);\n    vec3 p1 = ceil(pos * gridDim);\n    vec3 pd = (pos * gridDim - p0) / (p1 - p0);\n    vec4 s000 = readFromTexture(tex, offset + p0.z + p0.y * gdZ + p0.x * gdYZ, texDim);\n    vec4 s100 = readFromTexture(tex, offset + p0.z + p0.y * gdZ + p1.x * gdYZ, texDim);\n    vec4 s001 = readFromTexture(tex, offset + p1.z + p0.y * gdZ + p0.x * gdYZ, texDim);\n    vec4 s101 = readFromTexture(tex, offset + p1.z + p0.y * gdZ + p1.x * gdYZ, texDim);\n    vec4 s010 = readFromTexture(tex, offset + p0.z + p1.y * gdZ + p0.x * gdYZ, texDim);\n    vec4 s110 = readFromTexture(tex, offset + p0.z + p1.y * gdZ + p1.x * gdYZ, texDim);\n    vec4 s011 = readFromTexture(tex, offset + p1.z + p1.y * gdZ + p0.x * gdYZ, texDim);\n    vec4 s111 = readFromTexture(tex, offset + p1.z + p1.y * gdZ + p1.x * gdYZ, texDim);\n    vec4 s00 = mix(s000, s100, pd.x);\n    vec4 s01 = mix(s001, s101, pd.x);\n    vec4 s10 = mix(s010, s110, pd.x);\n    vec4 s11 = mix(s011, s111, pd.x);\n    vec4 s0 = mix(s00, s10, pd.y);\n    vec4 s1 = mix(s01, s11, pd.y);\n    return mix(s0, s1, pd.z);\n}\n",texture3d_from_2d_linear:"\nvec4 texture3dFrom2dLinear(sampler2D tex, vec3 pos, vec3 gridDim, vec2 texDim) {\n    float zSlice0 = floor(pos.z * gridDim.z);\n    float column0 = intMod(zSlice0 * gridDim.x, texDim.x) / gridDim.x;\n    float row0 = floor(intDiv(zSlice0 * gridDim.x, texDim.x));\n    vec2 coord0 = (vec2(column0 * gridDim.x, row0 * gridDim.y) + (pos.xy * gridDim.xy)) / texDim;\n    vec4 color0 = texture2D(tex, coord0);\n\n    float zSlice1 = zSlice0 + 1.0;\n    float column1 = intMod(zSlice1 * gridDim.x, texDim.x) / gridDim.x;\n    float row1 = floor(intDiv(zSlice1 * gridDim.x, texDim.x));\n    vec2 coord1 = (vec2(column1 * gridDim.x, row1 * gridDim.y) + (pos.xy * gridDim.xy)) / texDim;\n    vec4 color1 = texture2D(tex, coord1);\n\n    float delta0 = abs((pos.z * gridDim.z) - zSlice0);\n    return mix(color0, color1, delta0);\n}\n",texture3d_from_2d_nearest:"\nvec4 texture3dFrom2dNearest(sampler2D tex, vec3 pos, vec3 gridDim, vec2 texDim) {\n    float zSlice = floor(pos.z * gridDim.z + 0.5); // round to nearest z-slice\n    float column = intMod(zSlice * gridDim.x, texDim.x) / gridDim.x;\n    float row = floor(intDiv(zSlice * gridDim.x, texDim.x));\n    vec2 coord = (vec2(column * gridDim.x, row * gridDim.y) + (pos.xy * gridDim.xy)) / texDim;\n    return texture2D(tex, coord);\n}\n",wboit_params:"\n#if defined(dRenderVariant_colorWboit)\n    #if !defined(dRenderMode_volume) && !defined(dRenderMode_isosurface)\n        uniform sampler2D tDepth;\n        uniform vec2 uDrawingBufferSize;\n\n        float getDepth(const in vec2 coords) {\n            // always packed due to merged depth from primitives and volumes\n            return unpackRGBAToDepth(texture2D(tDepth, coords));\n        }\n    #endif\n#endif\n\nuniform bool uRenderWboit;\n\nfloat calcDepth(const in vec3 pos) {\n    vec2 clipZW = pos.z * uProjection[2].zw + uProjection[3].zw;\n    return 0.5 + 0.5 * clipZW.x / clipZW.y;\n}\n",wboit_write:"\n#if defined(dRenderVariant_colorWboit)\n    if (!uRenderWboit) {\n        if (preFogAlpha < 1.0) {\n            discard;\n        }\n    } else if (uRenderWboit) {\n        // the 'fragmentDepth > 0.99' check is to handle precision issues with packed depth\n        if (preFogAlpha != 1.0 && !interior && (fragmentDepth < getDepth(gl_FragCoord.xy / uDrawingBufferSize) || fragmentDepth > 0.99)) {\n            float alpha = gl_FragColor.a;\n            float wboitWeight = alpha * clamp(pow(1.0 - fragmentDepth, 2.0), 0.01, 1.0);\n            gl_FragColor = vec4(gl_FragColor.rgb * alpha * wboitWeight, alpha);\n            // extra alpha is to handle pre-multiplied alpha\n            #if !defined(dRenderMode_volume) && !defined(dRenderMode_isosurface)\n                gl_FragData[1] = vec4((uTransparentBackground ? alpha : 1.0) * alpha * wboitWeight);\n            #else\n                gl_FragData[1] = vec4(alpha * alpha * wboitWeight);\n            #endif\n        } else {\n            discard;\n        }\n    }\n#endif\n"},s=/^(?!\/\/)\s*#include\s+(\S+)/gim,u=/[ \t]*\/\/.*\n/g,c=/[ \t]*\/\*[\s\S]*?\*\//g,l=/\n{2,}/g;function d(e){return e.replace(s,(function(e,t){var r=o[t];if(!r)throw new Error("empty chunk, '"+t+"'");return r})).trim().replace(u,"\n").replace(c,"\n").replace(l,"\n")}function f(e,t,r,n,i){return void 0===n&&(n={}),void 0===i&&(i={}),{id:a(),name:e,vert:d(t),frag:d(r),extensions:n,outTypes:i}}var p=f("points","\nprecision highp float;\nprecision highp int;\n\n#include common\n#include read_from_texture\n#include common_vert_params\n#include color_vert_params\n#include size_vert_params\n#include common_clip\n\nuniform float uPixelRatio;\nuniform float uViewportHeight;\n\nattribute vec3 aPosition;\nattribute mat4 aTransform;\nattribute float aInstance;\nattribute float aGroup;\n\nvoid main(){\n    #include assign_group\n    #include assign_color_varying\n    #include assign_marker_varying\n    #include assign_clipping_varying\n    #include assign_position\n    #include assign_size\n\n    #ifdef dPointSizeAttenuation\n        gl_PointSize = size * uPixelRatio * ((uViewportHeight / 2.0) / -mvPosition.z) * 5.0;\n    #else\n        gl_PointSize = size * uPixelRatio;\n    #endif\n\n    gl_Position = uProjection * mvPosition;\n\n    #include clip_instance\n}\n","\nprecision highp float;\nprecision highp int;\n\n#include common\n#include common_frag_params\n#include color_frag_params\n#include common_clip\n#include wboit_params\n\n#ifdef dPointFilledCircle\n    uniform float uPointEdgeBleach;\n#endif\n\nconst vec2 center = vec2(0.5);\nconst float radius = 0.5;\n\nvoid main(){\n    #include clip_pixel\n\n    float fragmentDepth = gl_FragCoord.z;\n    bool interior = false;\n    #include assign_material_color\n\n    #if defined(dRenderVariant_pick)\n        #include check_picking_alpha\n        gl_FragColor = material;\n    #elif defined(dRenderVariant_depth)\n        gl_FragColor = material;\n    #elif defined(dRenderVariant_color)\n        gl_FragColor = material;\n\n        #ifdef dPointFilledCircle\n            float dist = distance(gl_PointCoord, center);\n            float alpha = 1.0 - smoothstep(radius - uPointEdgeBleach, radius, dist);\n            if (alpha < 0.0001) discard;\n            gl_FragColor.a *= alpha;\n        #endif\n\n        #include apply_marker_color\n        #include apply_fog\n        #include wboit_write\n    #endif\n}\n",{drawBuffers:"optional"}),m=f("spheres",'\nprecision highp float;\nprecision highp int;\n\n#include common\n#include read_from_texture\n#include common_vert_params\n#include color_vert_params\n#include size_vert_params\n#include common_clip\n\nuniform mat4 uModelView;\nuniform mat4 uInvProjection;\n\nattribute vec3 aPosition;\nattribute vec2 aMapping;\nattribute mat4 aTransform;\nattribute float aInstance;\nattribute float aGroup;\n\nvarying float vRadius;\nvarying float vRadiusSq;\nvarying vec3 vPoint;\nvarying vec3 vPointViewPosition;\n\n#include matrix_scale\n\nconst mat4 D = mat4(\n    1.0, 0.0, 0.0, 0.0,\n    0.0, 1.0, 0.0, 0.0,\n    0.0, 0.0, 1.0, 0.0,\n    0.0, 0.0, 0.0, -1.0\n);\n\n/**\n * Compute point size and center using the technique described in:\n * "GPU-Based Ray-Casting of Quadratic Surfaces" http://dl.acm.org/citation.cfm?id=2386396\n * by Christian Sigg, Tim Weyrich, Mario Botsch, Markus Gross.\n */\nvoid quadraticProjection(const in float radius, const in vec3 position){\n    vec2 xbc, ybc;\n\n    mat4 T = mat4(\n        radius, 0.0, 0.0, 0.0,\n        0.0, radius, 0.0, 0.0,\n        0.0, 0.0, radius, 0.0,\n        position.x, position.y, position.z, 1.0\n    );\n\n    mat4 R = transpose4(uProjection * uModelView * aTransform * T);\n    float A = dot(R[3], D * R[3]);\n    float B = -2.0 * dot(R[0], D * R[3]);\n    float C = dot(R[0], D * R[0]);\n    xbc[0] = (-B - sqrt(B * B - 4.0 * A * C)) / (2.0 * A);\n    xbc[1] = (-B + sqrt(B * B - 4.0 * A * C)) / (2.0 * A);\n    float sx = abs(xbc[0] - xbc[1]) * 0.5;\n\n    A = dot(R[3], D * R[3]);\n    B = -2.0 * dot(R[1], D * R[3]);\n    C = dot(R[1], D * R[1]);\n    ybc[0] = (-B - sqrt(B * B - 4.0 * A * C)) / (2.0 * A);\n    ybc[1] = (-B + sqrt(B * B - 4.0 * A * C)) / (2.0 * A);\n    float sy = abs(ybc[0] - ybc[1]) * 0.5;\n\n    gl_Position.xy = vec2(0.5 * (xbc.x + xbc.y), 0.5 * (ybc.x + ybc.y));\n    gl_Position.xy -= aMapping * vec2(sx, sy);\n    gl_Position.xy *= gl_Position.w;\n}\n\n\nvoid main(void){\n    #include assign_group\n    #include assign_color_varying\n    #include assign_marker_varying\n    #include assign_clipping_varying\n    #include assign_size\n\n    vRadius = size * matrixScale(uModelView);\n\n    vec4 position4 = vec4(aPosition, 1.0);\n    vec4 mvPosition = uModelView * aTransform * position4;\n    mvPosition.z -= vRadius; // avoid clipping, added again in fragment shader\n\n    gl_Position = uProjection * vec4(mvPosition.xyz, 1.0);\n    quadraticProjection(size, aPosition);\n\n    vRadiusSq = vRadius * vRadius;\n    vec4 vPoint4 = uInvProjection * gl_Position;\n    vPoint = vPoint4.xyz / vPoint4.w;\n    vPointViewPosition = -mvPosition.xyz / mvPosition.w;\n\n    vModelPosition = (uModel * aTransform * position4).xyz; // for clipping in frag shader\n\n    #include clip_instance\n}\n',"\nprecision highp float;\nprecision highp int;\n\n#include common\n#include common_frag_params\n#include color_frag_params\n#include light_frag_params\n#include common_clip\n#include wboit_params\n\nvarying float vRadius;\nvarying float vRadiusSq;\nvarying vec3 vPoint;\nvarying vec3 vPointViewPosition;\n\nvec3 cameraPos;\nvec3 cameraNormal;\n\nbool Impostor(out vec3 cameraPos, out vec3 cameraNormal){\n    vec3 cameraSpherePos = -vPointViewPosition;\n    cameraSpherePos.z += vRadius;\n\n    vec3 rayOrigin = mix(vec3(0.0, 0.0, 0.0), vPoint, uIsOrtho);\n    vec3 rayDirection = mix(normalize(vPoint), vec3(0.0, 0.0, 1.0), uIsOrtho);\n    vec3 cameraSphereDir = mix(cameraSpherePos, rayOrigin - cameraSpherePos, uIsOrtho);\n\n    float B = dot(rayDirection, cameraSphereDir);\n    float det = B * B + vRadiusSq - dot(cameraSphereDir, cameraSphereDir);\n\n    if (det < 0.0){\n        discard;\n        return false;\n    }\n\n    float sqrtDet = sqrt(det);\n    float posT = mix(B + sqrtDet, B + sqrtDet, uIsOrtho);\n    float negT = mix(B - sqrtDet, sqrtDet - B, uIsOrtho);\n\n    cameraPos = rayDirection * negT + rayOrigin;\n\n\n    if (calcDepth(cameraPos) <= 0.0) {\n        cameraPos = rayDirection * posT + rayOrigin;\n        interior = true;\n    } else {\n        interior = false;\n    }\n\n    cameraNormal = normalize(cameraPos - cameraSpherePos);\n    cameraNormal *= float(!interior) * 2.0 - 1.0;\n\n    return !interior;\n}\n\nvoid main(void){\n    #include clip_pixel\n\n    bool flag = Impostor(cameraPos, cameraNormal);\n    #ifndef dDoubleSided\n        if (interior)\n            discard;\n    #endif\n\n    vec3 vViewPosition = cameraPos;\n    gl_FragDepthEXT = calcDepth(vViewPosition);\n    if (!flag && gl_FragDepthEXT >= 0.0) {\n        gl_FragDepthEXT = 0.0 + (0.0000001 / vRadius);\n    }\n\n    // bugfix (mac only?)\n    if (gl_FragDepthEXT < 0.0) discard;\n    if (gl_FragDepthEXT > 1.0) discard;\n\n    float fragmentDepth = gl_FragDepthEXT;\n    #include assign_material_color\n\n    #if defined(dRenderVariant_pick)\n        #include check_picking_alpha\n        gl_FragColor = material;\n    #elif defined(dRenderVariant_depth)\n        gl_FragColor = material;\n    #elif defined(dRenderVariant_color)\n        #ifdef dIgnoreLight\n            gl_FragColor = material;\n        #else\n            vec3 normal = -cameraNormal;\n            #include apply_light_color\n        #endif\n\n        #include apply_interior_color\n        #include apply_marker_color\n        #include apply_fog\n        #include wboit_write\n    #endif\n}\n",{fragDepth:"required",drawBuffers:"optional"}),h=f("cylinders","\nprecision highp float;\nprecision highp int;\n\n#include common\n#include read_from_texture\n#include common_vert_params\n#include color_vert_params\n#include size_vert_params\n#include common_clip\n\nuniform mat4 uModelView;\n\nattribute mat4 aTransform;\nattribute float aInstance;\nattribute float aGroup;\n\nattribute vec3 aMapping;\nattribute vec3 aStart;\nattribute vec3 aEnd;\nattribute float aScale;\nattribute float aCap;\n\nvarying mat4 vTransform;\nvarying vec3 vStart;\nvarying vec3 vEnd;\nvarying float vSize;\nvarying float vCap;\n\nuniform float uIsOrtho;\nuniform vec3 uCameraDir;\n\nvoid main() {\n    #include assign_group\n    #include assign_color_varying\n    #include assign_marker_varying\n    #include assign_clipping_varying\n    #include assign_size\n\n    mat4 modelTransform = uModel * aTransform;\n\n    vTransform = aTransform;\n    vStart = (modelTransform * vec4(aStart, 1.0)).xyz;\n    vEnd = (modelTransform * vec4(aEnd, 1.0)).xyz;\n    vSize = size * aScale;\n    vCap = aCap;\n\n    vModelPosition = (vStart + vEnd) * 0.5;\n    vec3 camDir = -mix(normalize(vModelPosition - uCameraPosition), uCameraDir, uIsOrtho);\n    vec3 dir = vEnd - vStart;\n    // ensure cylinder 'dir' is pointing towards the camera\n    if(dot(camDir, dir) < 0.0) dir = -dir;\n\n    vec3 left = cross(camDir, dir);\n    vec3 up = cross(left, dir);\n    left = vSize * normalize(left);\n    up = vSize * normalize(up);\n\n    // move vertex in object-space from center to corner\n    vModelPosition += aMapping.x * dir + aMapping.y * left + aMapping.z * up;\n\n    vec4 mvPosition = uView * vec4(vModelPosition, 1.0);\n    vViewPosition = mvPosition.xyz;\n    gl_Position = uProjection * mvPosition;\n\n    #include clip_instance\n}\n","\nprecision highp float;\nprecision highp int;\n\nuniform mat4 uView;\n\nvarying mat4 vTransform;\nvarying vec3 vStart;\nvarying vec3 vEnd;\nvarying float vSize;\nvarying float vCap;\n\nuniform vec3 uCameraDir;\nuniform vec3 uCameraPosition;\n\n#include common\n#include common_frag_params\n#include color_frag_params\n#include light_frag_params\n#include common_clip\n#include wboit_params\n\n// adapted from https://www.shadertoy.com/view/4lcSRn\n// The MIT License, Copyright 2016 Inigo Quilez\nbool CylinderImpostor(\n    in vec3 rayOrigin, in vec3 rayDir,\n    in vec3 start, in vec3 end, in float radius,\n    out vec4 intersection, out bool interior\n){\n    vec3 ba = end - start;\n    vec3 oc = rayOrigin - start;\n\n    float baba = dot(ba, ba);\n    float bard = dot(ba, rayDir);\n    float baoc = dot(ba, oc);\n\n    float k2 = baba - bard*bard;\n    float k1 = baba * dot(oc, rayDir) - baoc * bard;\n    float k0 = baba * dot(oc, oc) - baoc * baoc - radius * radius * baba;\n\n    float h = k1 * k1 - k2 * k0;\n    if (h < 0.0) return false;\n\n    bool topCap = (vCap > 0.9 && vCap < 1.1) || vCap >= 2.9;\n    bool bottomCap = (vCap > 1.9 && vCap < 2.1) || vCap >= 2.9;\n\n    // body outside\n    h = sqrt(h);\n    float t = (-k1 - h) / k2;\n    float y = baoc + t * bard;\n    if (y > 0.0 && y < baba) {\n        interior = false;\n        intersection = vec4(t, (oc + t * rayDir - ba * y / baba) / radius);\n        return true;\n    }\n\n    if (topCap && y < 0.0) {\n        // top cap\n        t = -baoc / bard;\n        if (abs(k1 + k2 * t) < h) {\n            interior = false;\n            intersection = vec4(t, ba * sign(y) / baba);\n            return true;\n        }\n    } else if(bottomCap && y >= 0.0) {\n        // bottom cap\n        t = (baba - baoc) / bard;\n        if (abs(k1 + k2 * t) < h) {\n            interior = false;\n            intersection = vec4(t, ba * sign(y) / baba);\n            return true;\n        }\n    }\n\n    #ifdef dDoubleSided\n        // body inside\n        h = -h;\n        t = (-k1 - h) / k2;\n        y = baoc + t * bard;\n        if (y > 0.0 && y < baba) {\n            interior = true;\n            intersection = vec4(t, (oc + t * rayDir - ba * y / baba) / radius);\n            return true;\n        }\n\n        // TODO: handle inside caps???\n    #endif\n\n    return false;\n}\n\nvoid main() {\n    #include clip_pixel\n\n    vec3 rayDir = mix(normalize(vModelPosition - uCameraPosition), uCameraDir, uIsOrtho);\n\n    vec4 intersection;\n    bool interior;\n    bool hit = CylinderImpostor(vModelPosition, rayDir, vStart, vEnd, vSize, intersection, interior);\n    if (!hit) discard;\n\n    vec3 vViewPosition = vModelPosition + intersection.x * rayDir;\n    vViewPosition = (uView * vec4(vViewPosition, 1.0)).xyz;\n    gl_FragDepthEXT = calcDepth(vViewPosition);\n\n    // bugfix (mac only?)\n    if (gl_FragDepthEXT < 0.0) discard;\n    if (gl_FragDepthEXT > 1.0) discard;\n\n    float fragmentDepth = gl_FragDepthEXT;\n    #include assign_material_color\n\n    #if defined(dRenderVariant_pick)\n        #include check_picking_alpha\n        gl_FragColor = material;\n    #elif defined(dRenderVariant_depth)\n        gl_FragColor = material;\n    #elif defined(dRenderVariant_color)\n        #ifdef dIgnoreLight\n            gl_FragColor = material;\n        #else\n            mat3 normalMatrix = transpose3(inverse3(mat3(uView)));\n            vec3 normal = normalize(normalMatrix * -normalize(intersection.yzw));\n            #include apply_light_color\n        #endif\n\n        #include apply_interior_color\n        #include apply_marker_color\n        #include apply_fog\n        #include wboit_write\n    #endif\n}\n",{fragDepth:"required",drawBuffers:"optional"}),g=f("text","\nprecision highp float;\nprecision highp int;\n\n#include common\n#include read_from_texture\n#include common_vert_params\n#include color_vert_params\n#include size_vert_params\n#include common_clip\n\nuniform mat4 uModelView;\n\nattribute vec3 aPosition;\nattribute vec2 aMapping;\nattribute float aDepth;\nattribute vec2 aTexCoord;\nattribute mat4 aTransform;\nattribute float aInstance;\nattribute float aGroup;\n\nuniform float uOffsetX;\nuniform float uOffsetY;\nuniform float uOffsetZ;\n\n// uniform bool ortho;\nuniform float uPixelRatio;\nuniform float uViewportHeight;\n\nvarying vec2 vTexCoord;\n\n#include matrix_scale\n\nvoid main(void){\n    #include assign_group\n    #include assign_color_varying\n    #include assign_marker_varying\n    #include assign_clipping_varying\n    #include assign_size\n\n    vTexCoord = aTexCoord;\n\n    float scale = matrixScale(uModelView);\n\n    float offsetX = uOffsetX * scale;\n    float offsetY = uOffsetY * scale;\n    float offsetZ = (uOffsetZ + aDepth * 0.95) * scale;\n\n    vec4 position4 = vec4(aPosition, 1.0);\n    vec4 mvPosition = uModelView * aTransform * position4;\n\n    vModelPosition = (uModel * aTransform * position4).xyz; // for clipping in frag shader\n\n    // TODO\n    // #ifdef FIXED_SIZE\n    //     if (ortho) {\n    //         scale /= pixelRatio * ((uViewportHeight / 2.0) / -uCameraPosition.z) * 0.1;\n    //     } else {\n    //         scale /= pixelRatio * ((uViewportHeight / 2.0) / -mvPosition.z) * 0.1;\n    //     }\n    // #endif\n\n    vec4 mvCorner = vec4(mvPosition.xyz, 1.0);\n\n    if (vTexCoord.x == 10.0) { // indicates background plane\n        // move a bit to the back, taking distance to camera into account to avoid z-fighting\n        offsetZ -= 0.001 * distance(uCameraPosition, (uProjection * mvCorner).xyz);\n    }\n\n    mvCorner.xy += aMapping * size * scale;\n    mvCorner.x += offsetX;\n    mvCorner.y += offsetY;\n\n    // TODO\n    // if(ortho){\n    //     mvCorner.xyz += normalize(-uCameraPosition) * offsetZ;\n    // } else {\n    //     mvCorner.xyz += normalize(-mvCorner.xyz) * offsetZ;\n    // }\n    mvCorner.xyz += normalize(-mvCorner.xyz) * offsetZ;\n\n    gl_Position = uProjection * mvCorner;\n\n    vViewPosition = -mvCorner.xyz;\n\n    #include clip_instance\n}\n","\nprecision highp float;\nprecision highp int;\n\n#include common\n#include common_frag_params\n#include color_frag_params\n#include common_clip\n#include wboit_params\n\nuniform sampler2D tFont;\n\nuniform vec3 uBorderColor;\nuniform float uBorderWidth;\nuniform vec3 uBackgroundColor;\nuniform float uBackgroundOpacity;\n\nvarying vec2 vTexCoord;\n\nconst float smoothness = 32.0;\nconst float gamma = 2.2;\n\nvoid main2(){\n    gl_FragColor = vec4(1.0, 0.0, 0.0, 1.0);\n}\n\nvoid main(){\n    #include clip_pixel\n\n    float fragmentDepth = gl_FragCoord.z;\n    bool interior = false;\n    #include assign_material_color\n\n    if (vTexCoord.x > 1.0) {\n        gl_FragColor = vec4(uBackgroundColor, uBackgroundOpacity * material.a);\n    } else {\n        // retrieve signed distance\n        float sdf = texture2D(tFont, vTexCoord).a + uBorderWidth;\n\n        // perform adaptive anti-aliasing of the edges\n        float w = clamp(smoothness * (abs(dFdx(vTexCoord.x)) + abs(dFdy(vTexCoord.y))), 0.0, 0.5);\n        float a = smoothstep(0.5 - w, 0.5 + w, sdf);\n\n        // gamma correction for linear attenuation\n        a = pow(a, 1.0 / gamma);\n\n        if (a < 0.5) discard;\n        material.a *= a;\n\n        // add border\n        float t = 0.5 + uBorderWidth;\n        if (uBorderWidth > 0.0 && sdf < t) {\n            material.xyz = mix(uBorderColor, material.xyz, smoothstep(t - w, t, sdf));\n        }\n\n        gl_FragColor = material;\n    }\n\n    #if defined(dRenderVariant_pick)\n        #include check_picking_alpha\n    #elif defined(dRenderVariant_depth)\n        gl_FragColor = material;\n    #elif defined(dRenderVariant_color)\n        #include apply_marker_color\n        #include apply_fog\n        #include wboit_write\n    #endif\n}\n",{standardDerivatives:"required",drawBuffers:"optional"}),v=f("lines","\nprecision highp float;\nprecision highp int;\n\n#include common\n#include read_from_texture\n#include common_vert_params\n#include color_vert_params\n#include size_vert_params\n#include common_clip\n\nuniform float uPixelRatio;\nuniform float uViewportHeight;\n\nattribute mat4 aTransform;\nattribute float aInstance;\nattribute float aGroup;\n\nattribute vec2 aMapping;\nattribute vec3 aStart;\nattribute vec3 aEnd;\n\nvoid trimSegment(const in vec4 start, inout vec4 end) {\n    // trim end segment so it terminates between the camera plane and the near plane\n    // conservative estimate of the near plane\n    float a = uProjection[2][2];  // 3rd entry in 3rd column\n    float b = uProjection[3][2];  // 3rd entry in 4th column\n    float nearEstimate = -0.5 * b / a;\n    float alpha = (nearEstimate - start.z) / (end.z - start.z);\n    end.xyz = mix(start.xyz, end.xyz, alpha);\n}\n\nvoid main(){\n    #include assign_group\n    #include assign_color_varying\n    #include assign_marker_varying\n    #include assign_clipping_varying\n    #include assign_size\n\n    mat4 modelView = uView * uModel * aTransform;\n\n    // camera space\n    vec4 start = modelView * vec4(aStart, 1.0);\n    vec4 end = modelView * vec4(aEnd, 1.0);\n\n    // assign position\n    vec4 position4 = vec4((aMapping.y < 0.5) ? aStart : aEnd, 1.0);\n    vec4 mvPosition = modelView * position4;\n    vViewPosition = mvPosition.xyz;\n\n    vModelPosition = (uModel * aTransform * position4).xyz; // for clipping in frag shader\n\n    // special case for perspective projection, and segments that terminate either in, or behind, the camera plane\n    // clearly the gpu firmware has a way of addressing this issue when projecting into ndc space\n    // but we need to perform ndc-space calculations in the shader, so we must address this issue directly\n    // perhaps there is a more elegant solution -- WestLangley\n    bool perspective = (uProjection[2][3] == -1.0); // 4th entry in the 3rd column\n    if (perspective) {\n        if (start.z < 0.0 && end.z >= 0.0) {\n            trimSegment(start, end);\n        } else if (end.z < 0.0 && start.z >= 0.0) {\n            trimSegment(end, start);\n        }\n    }\n\n    // clip space\n    vec4 clipStart = uProjection * start;\n    vec4 clipEnd = uProjection * end;\n\n    // ndc space\n    vec2 ndcStart = clipStart.xy / clipStart.w;\n    vec2 ndcEnd = clipEnd.xy / clipEnd.w;\n\n    // direction\n    vec2 dir = ndcEnd - ndcStart;\n\n    // account for clip-space aspect ratio\n    dir.x *= uPixelRatio;\n    dir = normalize(dir);\n\n    // perpendicular to dir\n    vec2 offset = vec2(dir.y, - dir.x);\n\n    // undo aspect ratio adjustment\n    dir.x /= uPixelRatio;\n    offset.x /= uPixelRatio;\n\n    // sign flip\n    if (aMapping.x < 0.0) offset *= -1.0;\n\n    // calculate linewidth\n    float linewidth;\n    #ifdef dLineSizeAttenuation\n        linewidth = size * uPixelRatio * ((uViewportHeight / 2.0) / -start.z) * 5.0;\n    #else\n        linewidth = size * uPixelRatio;\n    #endif\n\n    // adjust for linewidth\n    offset *= linewidth;\n\n    // adjust for clip-space to screen-space conversion\n    offset /= uViewportHeight;\n\n    // select end\n    vec4 clip = (aMapping.y < 0.5) ? clipStart : clipEnd;\n\n    // back to clip space\n    offset *= clip.w;\n    clip.xy += offset;\n    gl_Position = clip;\n\n    #include clip_instance\n}\n","\nprecision highp float;\nprecision highp int;\n\n#include common\n#include common_frag_params\n#include color_frag_params\n#include common_clip\n#include wboit_params\n\nvoid main(){\n    #include clip_pixel\n\n    bool interior = false;\n    float fragmentDepth = gl_FragCoord.z;\n    #include assign_material_color\n\n    #if defined(dRenderVariant_pick)\n        #include check_picking_alpha\n        gl_FragColor = material;\n    #elif defined(dRenderVariant_depth)\n        gl_FragColor = material;\n    #elif defined(dRenderVariant_color)\n        gl_FragColor = material;\n\n        #include apply_marker_color\n        #include apply_fog\n        #include wboit_write\n    #endif\n}\n",{drawBuffers:"optional"}),b=f("mesh","\nprecision highp float;\nprecision highp int;\nprecision highp sampler2D;\n\n#include common\n#include read_from_texture\n#include common_vert_params\n#include color_vert_params\n#include common_clip\n\n#ifdef dGeoTexture\n    uniform vec2 uGeoTexDim;\n    uniform sampler2D tPosition;\n    uniform sampler2D tGroup;\n    uniform sampler2D tNormal;\n#else\n    attribute vec3 aPosition;\n    attribute float aGroup;\n    attribute vec3 aNormal;\n#endif\nattribute mat4 aTransform;\nattribute float aInstance;\n\nvarying vec3 vNormal;\n\nvoid main(){\n    #include assign_group\n    #include assign_color_varying\n    #include assign_marker_varying\n    #include assign_clipping_varying\n    #include assign_position\n    #include clip_instance\n\n    #ifdef dGeoTexture\n        vec3 normal = readFromTexture(tNormal, VertexID, uGeoTexDim).xyz;\n    #else\n        vec3 normal = aNormal;\n    #endif\n    mat3 normalMatrix = transpose3(inverse3(mat3(modelView)));\n    vec3 transformedNormal = normalize(normalMatrix * normalize(normal));\n    #if defined(dFlipSided) && !defined(dDoubleSided) // TODO checking dDoubleSided should not be required, ASR\n        transformedNormal = -transformedNormal;\n    #endif\n    vNormal = transformedNormal;\n}\n","\nprecision highp float;\nprecision highp int;\n\n#include common\n#include common_frag_params\n#include color_frag_params\n#include light_frag_params\n#include normal_frag_params\n#include common_clip\n#include wboit_params\n\nvoid main() {\n    #include clip_pixel\n\n    // Workaround for buggy gl_FrontFacing (e.g. on some integrated Intel GPUs)\n    #if defined(enabledStandardDerivatives)\n        vec3 fdx = dFdx(vViewPosition);\n        vec3 fdy = dFdy(vViewPosition);\n        vec3 faceNormal = normalize(cross(fdx,fdy));\n        bool frontFacing = dot(vNormal, faceNormal) > 0.0;\n    #else\n        bool frontFacing = dot(vNormal, vViewPosition) < 0.0;\n    #endif\n\n    #if defined(dFlipSided)\n        interior = frontFacing;\n    #else\n        interior = !frontFacing;\n    #endif\n\n    float fragmentDepth = gl_FragCoord.z;\n    #include assign_material_color\n\n    #if defined(dRenderVariant_pick)\n        #include check_picking_alpha\n        gl_FragColor = material;\n    #elif defined(dRenderVariant_depth)\n        gl_FragColor = material;\n    #elif defined(dRenderVariant_color)\n        #ifdef dIgnoreLight\n            gl_FragColor = material;\n        #else\n            #if defined(dFlatShaded) && defined(enabledStandardDerivatives)\n                vec3 normal = -faceNormal;\n            #else\n                vec3 normal = -normalize(vNormal);\n                #ifdef dDoubleSided\n                    normal = normal * (float(frontFacing) * 2.0 - 1.0);\n                #endif\n            #endif\n            #include apply_light_color\n        #endif\n\n        #include apply_interior_color\n        #include apply_marker_color\n        #include apply_fog\n        #include wboit_write\n    #endif\n}\n",{standardDerivatives:"optional",drawBuffers:"optional"}),y=f("direct-volume","\nprecision highp float;\n\nattribute vec3 aPosition;\nattribute mat4 aTransform;\nattribute float aInstance;\n\nuniform mat4 uModelView;\nuniform mat4 uProjection;\nuniform vec4 uInvariantBoundingSphere;\n\nvarying vec3 vOrigPos;\nvarying float vInstance;\nvarying vec4 vBoundingSphere;\nvarying mat4 vTransform;\n\nuniform vec3 uBboxSize;\nuniform vec3 uBboxMin;\nuniform vec3 uBboxMax;\nuniform vec3 uGridDim;\nuniform mat4 uTransform;\n\nuniform mat4 uUnitToCartn;\n\nvoid main() {\n    vec4 unitCoord = vec4(aPosition + vec3(0.5), 1.0);\n    vec4 mvPosition = uModelView * aTransform * uUnitToCartn * unitCoord;\n\n    vOrigPos = (aTransform * uUnitToCartn * unitCoord).xyz;\n    vInstance = aInstance;\n    vBoundingSphere = vec4(\n        (aTransform * vec4(uInvariantBoundingSphere.xyz, 1.0)).xyz,\n        uInvariantBoundingSphere.w\n    );\n    vTransform = aTransform;\n\n    gl_Position = uProjection * mvPosition;\n\n    // move z position to near clip plane (but not too close to get precision issues)\n    gl_Position.z = gl_Position.w - 0.01;\n}\n","\nprecision highp float;\nprecision highp int;\n\n#include common\n#include light_frag_params\n\n#if dClipObjectCount != 0\n    uniform int uClipObjectType[dClipObjectCount];\n    uniform bool uClipObjectInvert[dClipObjectCount];\n    uniform vec3 uClipObjectPosition[dClipObjectCount];\n    uniform vec4 uClipObjectRotation[dClipObjectCount];\n    uniform vec3 uClipObjectScale[dClipObjectCount];\n#endif\n#include common_clip\n\n#include read_from_texture\n#include texture3d_from_1d_trilinear\n#include texture3d_from_2d_nearest\n#include texture3d_from_2d_linear\n\nuniform mat4 uProjection, uTransform, uModelView, uModel, uView;\nuniform vec3 uCameraDir;\n\nuniform sampler2D tDepth;\nuniform vec2 uDrawingBufferSize;\n\nvarying vec3 vOrigPos;\nvarying float vInstance;\nvarying vec4 vBoundingSphere;\nvarying mat4 vTransform;\n\nuniform mat4 uInvView;\nuniform vec2 uIsoValue;\nuniform vec3 uGridDim;\nuniform vec3 uBboxSize;\nuniform sampler2D tTransferTex;\nuniform float uTransferScale;\nuniform float uStepScale;\nuniform float uJumpLength;\n\nuniform int uObjectId;\nuniform int uVertexCount;\nuniform int uInstanceCount;\nuniform int uGroupCount;\n\nuniform vec3 uHighlightColor;\nuniform vec3 uSelectColor;\nuniform vec2 uMarkerTexDim;\nuniform sampler2D tMarker;\n\nuniform float uFogNear;\nuniform float uFogFar;\nuniform vec3 uFogColor;\n\nuniform float uAlpha;\nuniform float uPickingAlphaThreshold;\nuniform bool uTransparentBackground;\n\nuniform float uInteriorDarkening;\nuniform bool uInteriorColorFlag;\nuniform vec3 uInteriorColor;\nbool interior;\n\nuniform float uNear;\nuniform float uFar;\nuniform float uIsOrtho;\n\nuniform vec3 uCellDim;\nuniform vec3 uCameraPosition;\nuniform mat4 uCartnToUnit;\n\n#if __VERSION__ != 100\n    // for webgl1 this is given as a 'define'\n    uniform int uMaxSteps;\n#endif\n\n#if defined(dGridTexType_2d)\n    precision highp sampler2D;\n    uniform sampler2D tGridTex;\n    uniform vec3 uGridTexDim;\n#elif defined(dGridTexType_3d)\n    precision highp sampler3D;\n    uniform sampler3D tGridTex;\n#endif\n\n#if defined(dRenderVariant_color)\n    #if defined(dColorType_uniform)\n        uniform vec3 uColor;\n    #elif defined(dColorType_texture)\n        uniform vec2 uColorTexDim;\n        uniform sampler2D tColor;\n    #endif\n\n    #ifdef dOverpaint\n        varying vec4 vOverpaint;\n        uniform vec2 uOverpaintTexDim;\n        uniform sampler2D tOverpaint;\n    #endif\n#endif\n\n#if defined(dGridTexType_2d)\n    vec4 textureVal(vec3 pos) {\n        return texture3dFrom2dLinear(tGridTex, pos + (vec3(0.5, 0.5, 0.0) / uGridDim), uGridDim, uGridTexDim.xy);\n    }\n    vec4 textureGroup(vec3 pos) {\n        return texture3dFrom2dNearest(tGridTex, pos + (vec3(0.5, 0.5, 0.0) / uGridDim), uGridDim, uGridTexDim.xy);\n    }\n#elif defined(dGridTexType_3d)\n    vec4 textureVal(vec3 pos) {\n        return texture(tGridTex, pos + (vec3(0.5) / uGridDim));\n    }\n    vec4 textureGroup(vec3 pos) {\n        return texelFetch(tGridTex, ivec3(pos * uGridDim), 0);\n    }\n#endif\n\n#include wboit_params\n\nvec4 transferFunction(float value) {\n    return texture2D(tTransferTex, vec2(value, 0.0));\n}\n\nfloat getDepth(const in vec2 coords) {\n    #ifdef depthTextureSupport\n        if (!uRenderWboit) {\n            // in case of opaque volumes (and depth texture support)\n            return texture2D(tDepth, coords).r;\n        } else {\n            return unpackRGBAToDepth(texture2D(tDepth, coords));\n        }\n    #else\n        return unpackRGBAToDepth(texture2D(tDepth, coords));\n    #endif\n}\n\nconst float gradOffset = 0.5;\n\nvec3 v3m4(vec3 p, mat4 m) {\n    return (m * vec4(p, 1.0)).xyz;\n}\n\nfloat preFogAlphaBlended = 0.0;\n\nvec4 raymarch(vec3 startLoc, vec3 step, vec3 rayDir) {\n    #if defined(dRenderVariant_color) && !defined(dIgnoreLight)\n        mat3 normalMatrix = transpose3(inverse3(mat3(uModelView * vTransform)));\n    #endif\n    mat4 cartnToUnit = uCartnToUnit * inverse4(vTransform);\n    #if defined(dClipVariant_pixel) && dClipObjectCount != 0\n        mat4 modelTransform = uModel * vTransform * uTransform;\n    #endif\n    mat4 modelViewTransform = uModelView * vTransform * uTransform;\n\n    vec3 scaleVol = vec3(1.0) / uGridDim;\n    vec3 pos = startLoc;\n    vec4 cell;\n    float prevValue = -1.0;\n    float value = 0.0;\n    vec4 src = vec4(0.0);\n    vec4 dst = vec4(0.0);\n    bool hit = false;\n    float fragmentDepth;\n\n    vec3 posMin = vec3(0.0);\n    vec3 posMax = vec3(1.0) - vec3(1.0) / uGridDim;\n\n    vec3 unitPos;\n    vec3 isoPos;\n\n    vec3 nextPos;\n    float nextValue;\n\n    vec3 color = vec3(0.45, 0.55, 0.8);\n    vec3 gradient = vec3(1.0);\n    vec3 dx = vec3(gradOffset * scaleVol.x, 0.0, 0.0);\n    vec3 dy = vec3(0.0, gradOffset * scaleVol.y, 0.0);\n    vec3 dz = vec3(0.0, 0.0, gradOffset * scaleVol.z);\n\n    float maxDist = min(vBoundingSphere.w * 2.0, uFar - uNear);\n    float maxDistSq = maxDist * maxDist;\n\n    for (int i = 0; i < uMaxSteps; ++i) {\n        // break when beyond bounding-sphere or far-plane\n        vec3 distVec = startLoc - pos;\n        if (dot(distVec, distVec) > maxDistSq) break;\n\n        unitPos = v3m4(pos, cartnToUnit);\n\n        // continue when outside of grid\n        if (unitPos.x > posMax.x || unitPos.y > posMax.y || unitPos.z > posMax.z ||\n            unitPos.x < posMin.x || unitPos.y < posMin.y || unitPos.z < posMin.z\n        ) {\n            if (hit) break;\n            prevValue = value;\n            pos += step;\n            continue;\n        }\n\n        cell = textureVal(unitPos);\n        value = cell.a; // current voxel value\n\n        if (uJumpLength > 0.0 && value < 0.01) {\n            nextPos = pos + rayDir * uJumpLength;\n            nextValue = textureVal(v3m4(nextPos, cartnToUnit)).a;\n            if (nextValue < 0.01) {\n                prevValue = nextValue;\n                pos = nextPos;\n                continue;\n            }\n        }\n\n        #if defined(dRenderMode_isosurface)\n            if (prevValue > 0.0 && ( // there was a prev Value\n                (prevValue < uIsoValue.x && value > uIsoValue.x) || // entering isosurface\n                (prevValue > uIsoValue.x && value < uIsoValue.x) // leaving isosurface\n            )) {\n                isoPos = v3m4(mix(pos - step, pos, ((prevValue - uIsoValue.x) / ((prevValue - uIsoValue.x) - (value - uIsoValue.x)))), cartnToUnit);\n\n                vec4 mvPosition = modelViewTransform * vec4(isoPos * uGridDim, 1.0);\n\n                #if defined(dClipVariant_pixel) && dClipObjectCount != 0\n                    vec3 vModelPosition = v3m4(isoPos * uGridDim, modelTransform);\n                    if (clipTest(vec4(vModelPosition, 0.0), 0)) {\n                        prevValue = value;\n                        pos += step;\n                        continue;\n                    }\n                #endif\n\n                float depth = calcDepth(mvPosition.xyz);\n                if (depth > getDepth(gl_FragCoord.xy / uDrawingBufferSize))\n                    break;\n\n                #ifdef enabledFragDepth\n                    if (!hit) {\n                        gl_FragDepthEXT = depth;\n                    }\n                #endif\n\n                #if defined(dRenderVariant_pickObject)\n                    return vec4(encodeFloatRGB(float(uObjectId)), 1.0);\n                #elif defined(dRenderVariant_pickInstance)\n                    return vec4(encodeFloatRGB(vInstance), 1.0);\n                #elif defined(dRenderVariant_pickGroup)\n                    #ifdef dPackedGroup\n                        return vec4(textureGroup(floor(isoPos * uGridDim + 0.5) / uGridDim).rgb, 1.0);\n                    #else\n                        vec3 g = floor(isoPos * uGridDim + 0.5);\n                        return vec4(encodeFloatRGB(g.z + g.y * uGridDim.z + g.x * uGridDim.z * uGridDim.y), 1.0);\n                    #endif\n                #elif defined(dRenderVariant_depth)\n                    #ifdef enabledFragDepth\n                        return packDepthToRGBA(gl_FragDepthEXT);\n                    #else\n                        return packDepthToRGBA(depth);\n                    #endif\n                #elif defined(dRenderVariant_color)\n                    #ifdef dPackedGroup\n                        float group = decodeFloatRGB(textureGroup(floor(isoPos * uGridDim + 0.5) / uGridDim).rgb);\n                    #else\n                        vec3 g = floor(isoPos * uGridDim + 0.5);\n                        float group = g.z + g.y * uGridDim.z + g.x * uGridDim.z * uGridDim.y;\n                    #endif\n\n                    #if defined(dColorType_uniform)\n                        color = uColor;\n                    #elif defined(dColorType_instance)\n                        color = readFromTexture(tColor, vInstance, uColorTexDim).rgb;\n                    #elif defined(dColorType_group)\n                        color = readFromTexture(tColor, group, uColorTexDim).rgb;\n                    #elif defined(dColorType_groupInstance)\n                        color = readFromTexture(tColor, vInstance * float(uGroupCount) + group, uColorTexDim).rgb;\n                    #elif defined(dColorType_vertex)\n                        color = texture3dFrom1dTrilinear(tColor, isoPos, uGridDim, uColorTexDim, 0.0).rgb;\n                    #elif defined(dColorType_vertexInstance)\n                        color = texture3dFrom1dTrilinear(tColor, isoPos, uGridDim, uColorTexDim, vInstance * float(uVertexCount)).rgb;\n                    #endif\n\n                    // handle flipping and negative isosurfaces\n                    #ifdef dFlipSided\n                        bool flipped = value < uIsoValue.y; // flipped\n                    #else\n                        bool flipped = value > uIsoValue.y;\n                    #endif\n                    interior = value < uIsoValue.x && flipped;\n                    #ifndef dDoubleSided\n                        if (interior) {\n                            prevValue = value;\n                            pos += step;\n                            continue;\n                        }\n                    #endif\n                    vec3 vViewPosition = mvPosition.xyz;\n                    vec4 material = vec4(color, uAlpha);\n\n                    #ifdef dIgnoreLight\n                        gl_FragColor = material;\n                    #else\n                        #if defined(dFlatShaded)\n                            // nearest grid point\n                            isoPos = floor(isoPos * uGridDim + 0.5) / uGridDim;\n                        #endif\n                        #ifdef dPackedGroup\n                            // compute gradient by central differences\n                            gradient.x = textureVal(isoPos - dx).a - textureVal(isoPos + dx).a;\n                            gradient.y = textureVal(isoPos - dy).a - textureVal(isoPos + dy).a;\n                            gradient.z = textureVal(isoPos - dz).a - textureVal(isoPos + dz).a;\n                        #else\n                            gradient = textureVal(isoPos).xyz * 2.0 - 1.0;\n                        #endif\n                        vec3 normal = -normalize(normalMatrix * normalize(gradient));\n                        normal = normal * (float(flipped) * 2.0 - 1.0);\n                        normal = normal * -(float(interior) * 2.0 - 1.0);\n                        #include apply_light_color\n                    #endif\n\n                    float vMarker = readFromTexture(tMarker, vInstance * float(uGroupCount) + group, uMarkerTexDim).a;\n                    #include apply_interior_color\n                    #include apply_marker_color\n\n                    preFogAlphaBlended = (1.0 - preFogAlphaBlended) * gl_FragColor.a + preFogAlphaBlended;\n                    fragmentDepth = depth;\n                    #include apply_fog\n\n                    src = gl_FragColor;\n\n                    if (!uTransparentBackground) {\n                        // done in 'apply_fog' otherwise\n                        src.rgb *= src.a;\n                    }\n                    dst = (1.0 - dst.a) * src + dst; // standard blending\n                #endif\n\n                #ifdef dSingleLayer\n                    break;\n                #endif\n\n                hit = true;\n            }\n            prevValue = value;\n        #elif defined(dRenderMode_volume)\n            vec4 mvPosition = modelViewTransform * vec4(unitPos * uGridDim, 1.0);\n            if (calcDepth(mvPosition.xyz) > getDepth(gl_FragCoord.xy / uDrawingBufferSize))\n                break;\n\n            #if defined(dClipVariant_pixel) && dClipObjectCount != 0\n                vec3 vModelPosition = v3m4(unitPos * uGridDim, modelTransform);\n                if (clipTest(vec4(vModelPosition, 0.0), 0)) {\n                    prevValue = value;\n                    pos += step;\n                    continue;\n                }\n            #endif\n\n            #if defined(dRenderVariant_color)\n                vec3 vViewPosition = mvPosition.xyz;\n                vec4 material = transferFunction(value);\n\n                #ifdef dIgnoreLight\n                    gl_FragColor.rgb = material.rgb;\n                #else\n                    if (material.a >= 0.01) {\n                        #ifdef dPackedGroup\n                            // compute gradient by central differences\n                            gradient.x = textureVal(unitPos - dx).a - textureVal(unitPos + dx).a;\n                            gradient.y = textureVal(unitPos - dy).a - textureVal(unitPos + dy).a;\n                            gradient.z = textureVal(unitPos - dz).a - textureVal(unitPos + dz).a;\n                        #else\n                            gradient = cell.xyz * 2.0 - 1.0;\n                        #endif\n                        vec3 normal = -normalize(normalMatrix * normalize(gradient));\n                        #include apply_light_color\n                    } else {\n                        gl_FragColor.rgb = material.rgb;\n                    }\n                #endif\n\n                gl_FragColor.a = material.a * uAlpha * uTransferScale;\n\n                #ifdef dPackedGroup\n                    float group = decodeFloatRGB(textureGroup(floor(unitPos * uGridDim + 0.5) / uGridDim).rgb);\n                #else\n                    vec3 g = floor(unitPos * uGridDim + 0.5);\n                    float group = g.z + g.y * uGridDim.z + g.x * uGridDim.z * uGridDim.y;\n                #endif\n\n                float vMarker = readFromTexture(tMarker, vInstance * float(uGroupCount) + group, uMarkerTexDim).a;\n                #include apply_marker_color\n\n                preFogAlphaBlended = (1.0 - preFogAlphaBlended) * gl_FragColor.a + preFogAlphaBlended;\n                fragmentDepth = calcDepth(mvPosition.xyz);\n                #include apply_fog\n\n                src = gl_FragColor;\n\n                if (!uTransparentBackground) {\n                    // done in 'apply_fog' otherwise\n                    src.rgb *= src.a;\n                }\n                dst = (1.0 - dst.a) * src + dst; // standard blending\n            #endif\n        #endif\n\n        // break if the color is opaque enough\n        if (dst.a > 0.95)\n            break;\n\n        pos += step;\n    }\n\n    #if defined(dRenderMode_isosurface) && defined(enabledFragDepth)\n        // ensure depth is written everywhere\n        if (!hit)\n            gl_FragDepthEXT = 1.0;\n    #endif\n\n    return dst;\n}\n\n// TODO: support float texture for higher precision values???\n// TODO: support clipping exclusion texture support\n\nvoid main() {\n    if (gl_FrontFacing)\n        discard;\n\n    #if defined(dRenderVariant_pick) || defined(dRenderVariant_depth)\n        #if defined(dRenderMode_volume)\n            // always ignore pick & depth for volume\n            discard;\n        #elif defined(dRenderMode_isosurface)\n            if (uAlpha < uPickingAlphaThreshold)\n                discard; // ignore so the element below can be picked\n        #endif\n    #endif\n\n    vec3 rayDir = mix(normalize(vOrigPos - uCameraPosition), uCameraDir, uIsOrtho);\n    vec3 step = rayDir * uStepScale;\n\n    float boundingSphereNear = distance(vBoundingSphere.xyz, uCameraPosition) - vBoundingSphere.w;\n    float d = max(uNear, boundingSphereNear) - mix(0.0, distance(vOrigPos, uCameraPosition), uIsOrtho);\n    vec3 start = mix(uCameraPosition, vOrigPos, uIsOrtho) + (d * rayDir);\n    gl_FragColor = raymarch(start, step, rayDir);\n\n    #if defined(dRenderVariant_pick) || defined(dRenderVariant_depth)\n        // discard when nothing was hit\n        if (gl_FragColor == vec4(0.0))\n            discard;\n    #endif\n\n    #if defined(dRenderVariant_color)\n        #if defined(dRenderMode_isosurface) && defined(enabledFragDepth)\n            float fragmentDepth = gl_FragDepthEXT;\n        #else\n            float fragmentDepth = calcDepth((uModelView * vec4(start, 1.0)).xyz);\n        #endif\n        float preFogAlpha = clamp(preFogAlphaBlended, 0.0, 1.0);\n        interior = false;\n        #include wboit_write\n    #endif\n}\n",{fragDepth:"optional",drawBuffers:"optional"}),_=f("image","\nprecision highp float;\nprecision highp int;\n\n#include common\n#include common_vert_params\n\nattribute vec3 aPosition;\nattribute vec2 aUv;\nattribute mat4 aTransform;\nattribute float aInstance;\n\nvarying vec2 vUv;\nvarying float vInstance;\n\nvoid main() {\n    #include assign_position\n\n    vUv = aUv;\n    vInstance = aInstance;\n}\n","\nprecision highp float;\nprecision highp int;\n\n#include common\n#include read_from_texture\n#include common_frag_params\n#include common_clip\n#include wboit_params\n\nuniform vec2 uImageTexDim;\nuniform sampler2D tImageTex;\nuniform sampler2D tGroupTex;\n\nuniform vec2 uMarkerTexDim;\nuniform sampler2D tMarker;\n\nvarying vec2 vUv;\nvarying float vInstance;\n\n#if defined(dInterpolation_catmulrom) || defined(dInterpolation_mitchell) || defined(dInterpolation_bspline)\n    #define dInterpolation_cubic\n#endif\n\n#if defined(dInterpolation_cubic)\n    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(imageData.a < 0.05)\n            discard;\n\n        gl_FragColor = packDepthToRGBA(gl_FragCoord.z);\n    #elif defined(dRenderVariant_color)\n        if (imageData.a < 0.05)\n            discard;\n\n        gl_FragColor = imageData;\n        gl_FragColor.a *= uAlpha;\n\n        float group = decodeFloatRGB(texture2D(tGroupTex, vUv).rgb);\n        float vMarker = readFromTexture(tMarker, vInstance * float(uGroupCount) + group, uMarkerTexDim).a;\n\n        #include apply_marker_color\n        #include apply_fog\n        #include wboit_write\n    #endif\n}\n",{drawBuffers:"optional"});function S(e,t,r,n){var o=function(e){if(void 0===e)return"";var t=[];for(var r in e){var n=e[r].ref.value;if(void 0!==n)if("string"==typeof n)t.push("#define "+r+"_"+n);else if("number"==typeof n)t.push("#define "+r+" "+n);else{if("boolean"!=typeof n)throw new Error("unknown define type");n&&t.push("#define "+r)}}return t.join("\n")+"\n"}(r),s=Object(i.q)(e)?"#version 300 es\n#define attribute in\n#define 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t.state={showHelp:!1},t.toggleHelp=function(){return t.setState({showHelp:!t.state.showHelp})},t}return Object(n.__extends)(t,e),t.prototype.update=function(e){this.props.onChange({param:this.props.param,name:this.props.name,value:e})},t.prototype.renderAddOn=function(){return null},t.prototype.render=function(){return I({props:this.props,state:this.state,control:this.renderControl(),toggleHelp:this.toggleHelp,addOn:this.renderAddOn()})},t}(i.PureComponent),k=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.onClick=function(e){t.update(!t.props.value),e.currentTarget.blur()},t}return Object(n.__extends)(t,e),t.prototype.renderControl=function(){return i.createElement("button",{onClick:this.onClick,disabled:this.props.isDisabled},i.createElement(_.Icon,{svg:this.props.value?_.CheckSvg:_.ClearSvg}),this.props.value?"On":"Off")},t}(M),B=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={isExpanded:!1,isOverPoint:!1,message:t.props.param.defaultValue.length+" points"},t.onHover=function(e){t.setState({isOverPoint:!t.state.isOverPoint}),e?t.setState({message:"("+e[0].toFixed(2)+", "+e[1].toFixed(2)+")"}):t.setState({message:t.props.value.length+" points"})},t.onDrag=function(e){t.setState({message:"("+e[0].toFixed(2)+", "+e[1].toFixed(2)+")"})},t.onChange=function(e){t.props.onChange({name:t.props.name,param:t.props.param,value:e})},t.toggleExpanded=function(e){t.setState({isExpanded:!t.state.isExpanded}),e.currentTarget.blur()},t}return Object(n.__extends)(t,e),t.prototype.render=function(){var e=this.props.param.label||Object(d.a)(this.props.name);return i.createElement(i.Fragment,null,i.createElement(m.ControlRow,{label:e,control:i.createElement("button",{onClick:this.toggleExpanded,disabled:this.props.isDisabled},""+this.state.message)}),i.createElement("div",{className:"msp-control-offset",style:{display:this.state.isExpanded?"block":"none"}},i.createElement(w,{data:this.props.param.defaultValue,onChange:this.onChange,onHover:this.onHover,onDrag:this.onDrag})))},t}(i.PureComponent),V=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={value:"0"},t.update=function(e){var r=Object(c.b)(t.props.param.step||.01);e=parseFloat(e.toFixed(r)),t.props.onChange({param:t.props.param,name:t.props.name,value:e})},t}return Object(n.__extends)(t,e),t.prototype.render=function(){var e=this.props.param.label||Object(d.a)(this.props.name),t=this.props.param.label||Object(d.a)(this.props.name),r=Object(c.b)(this.props.param.step||.01);return i.createElement(m.ControlRow,{title:this.props.param.description,label:t,control:i.createElement(m.TextInput,{numeric:!0,value:parseFloat(this.props.value.toFixed(r)),onEnter:this.props.onEnter,placeholder:e,isDisabled:this.props.isDisabled,onChange:this.update})})},t}(i.PureComponent),R=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.onChange=function(e){t.update(e)},t}return Object(n.__extends)(t,e),t.prototype.renderControl=function(){var e=void 0===this.props.value?this.props.param.defaultValue:this.props.value;return i.createElement(C.a,{value:e,min:this.props.param.min,max:this.props.param.max,step:this.props.param.step,onChange:this.onChange,onChangeImmediate:this.props.param.immediateUpdate?this.onChange:void 0,disabled:this.props.isDisabled,onEnter:this.props.onEnter})},t}(M),L=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.onChange=function(e){var 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t[0]===e.props.value}));return i.createElement("select",{className:"msp-form-control",title:this.props.title,value:void 0!==this.props.value?this.props.value:this.props.param.defaultValue,onChange:this.onChange,disabled:this.props.isDisabled},t&&i.createElement("option",{key:this.props.value,value:this.props.value},"[Invalid] "+this.props.value),this.props.param.options.map((function(e){var t=e[0],r=e[1];return i.createElement("option",{key:t,value:t},r)})))},t}(i.PureComponent),F=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={showHelp:!1,showOptions:!1},t.onSelect=function(e){e&&e.value!==t.props.value?t.setState({showOptions:!1},(function(){t.props.onChange({param:t.props.param,name:t.props.name,value:e.value})})):t.setState({showOptions:!1})},t.toggle=function(){return t.setState({showOptions:!t.state.showOptions})},t.cycle=function(){var e=t.props.param.options,r=e.findIndex((function(e){return e[0]===t.props.value})),n=r===e.length-1?0:r+1;t.props.onChange({param:t.props.param,name:t.props.name,value:e[n][0]})},t.items=Object(u.b)((function(e){return p.a.createItemsFromSelectOptions(e.options)})),t.toggleHelp=function(){return t.setState({showHelp:!t.state.showHelp})},t}return Object(n.__extends)(t,e),t.prototype.renderControl=function(){var e,t=this.items(this.props.param),r=void 0!==this.props.value?p.a.findItem(t,this.props.value):void 0,n=r?r.label:void 0===this.props.value?((null===(e=p.a.getFirstItem(t))||void 0===e?void 0:e.label)||"")+" [Default]":"[Invalid] "+this.props.value,a=this.props.param.cycle?this.cycle:this.toggle,o=this.props.param.cycle?"center":"left",s=this.props.param.cycle?"on"===this.props.value?_.CheckSvg:"off"===this.props.value?_.ClearSvg:void 0:void 0;return i.createElement(m.ToggleButton,{disabled:this.props.isDisabled,style:{textAlign:o,overflow:"hidden",textOverflow:"ellipsis"},label:n,title:n,icon:s,toggle:a,isSelected:this.state.showOptions})},t.prototype.renderAddOn=function(){if(!this.state.showOptions)return null;var e=this.items(this.props.param),t=p.a.findItem(e,this.props.value);return i.createElement(p.a,{items:e,current:t,onSelect:this.onSelect})},t.prototype.render=function(){return I({props:this.props,state:this.state,control:this.renderControl(),toggleHelp:this.toggleHelp,addOn:this.renderAddOn()})},t}(i.PureComponent),U=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={showHelp:!1,showOptions:!1},t.onSelect=function(e){e&&e.value!==t.props.value?t.setState({showOptions:!1},(function(){t.props.onChange({param:t.props.param,name:t.props.name,value:{ref:e.value}})})):t.setState({showOptions:!1})},t.toggle=function(){return t.setState({showOptions:!t.state.showOptions})},t.items=Object(u.b)((function(e){return p.a.createItemsFromSelectOptions(e.getOptions())})),t.toggleHelp=function(){return t.setState({showHelp:!t.state.showHelp})},t}return Object(n.__extends)(t,e),t.prototype.renderControl=function(){var e,t=this.items(this.props.param),r=this.props.value.ref?p.a.findItem(t,this.props.value.ref):void 0,n=r?r.label:"[Ref] "+(null!==(e=this.props.value.ref)&&void 0!==e?e:"");return i.createElement(m.ToggleButton,{disabled:this.props.isDisabled,style:{textAlign:"left",overflow:"hidden",textOverflow:"ellipsis"},label:n,title:n,toggle:this.toggle,isSelected:this.state.showOptions})},t.prototype.renderAddOn=function(){if(!this.state.showOptions)return null;var e=this.items(this.props.param),t=p.a.findItem(e,this.props.value.ref);return i.createElement(p.a,{items:e,current:t,onSelect:this.onSelect})},t.prototype.render=function(){return 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i.createElement(i.Fragment,null,i.createElement(m.ControlRow,{label:t,control:i.createElement("button",{onClick:this.toggleExpanded,disabled:this.props.isDisabled},n)}),this.state.isExpanded&&i.createElement("div",{className:"msp-control-offset"},i.createElement(P,{params:this.components,values:e,onChange:this.componentChange,onEnter:this.props.onEnter})))},t}(i.PureComponent),H=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.onChange=function(e){t.update(e)},t}return Object(n.__extends)(t,e),t.prototype.renderControl=function(){return i.createElement(C.b,{value:this.props.value,min:this.props.param.min,max:this.props.param.max,step:this.props.param.step,onChange:this.onChange,disabled:this.props.isDisabled,onEnter:this.props.onEnter})},t}(M),G=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.onChange=function(e){t.update(Object(o.Color)(parseInt(e.target.value)))},t}return 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e.color}))})},t.isInterpolatedChanged=function(e){var r=e.value;t.update({kind:r?"interpolate":"set",colors:t.props.value.colors})},t.toggleHelp=function(){return t.setState({showHelp:!t.state.showHelp})},t}return Object(n.__extends)(t,e),t.prototype.update=function(e){this.props.onChange({param:this.props.param,name:this.props.name,value:e})},t.prototype.renderControl=function(){var e=this.props.value;return i.createElement(i.Fragment,null,i.createElement("button",{onClick:this.toggleEdit,style:{position:"relative",paddingRight:"33px"}},1===e.colors.length?"1 color":e.colors.length+" colors",i.createElement("div",{style:Q(e,"33px")})),i.createElement(m.IconButton,{svg:_.BookmarksOutlinedSvg,onClick:this.togglePresets,toggleState:"presets"===this.state.show,title:"Color Presets",style:{padding:0,position:"absolute",right:0,top:0,width:"32px"}}))},t.prototype.renderColors=function(){if(!this.state.show)return null;var e=K(),t=e.ColorPresets,r=e.ColorsParam,n=e.IsInterpolatedParam,a=t[this.props.param.presetKind];if("presets"===this.state.show)return i.createElement(p.a,{items:a,onSelect:this.selectPreset});var o=this.props.value.colors.map((function(e){return{color:e}}));return i.createElement("div",{className:"msp-control-offset"},i.createElement(ce,{name:"colors",param:r,value:o,onChange:this.colorsChanged,isDisabled:this.props.isDisabled,onEnter:this.props.onEnter}),i.createElement(k,{name:"isInterpolated",param:n,value:"interpolate"===this.props.value.kind,onChange:this.isInterpolatedChanged,isDisabled:this.props.isDisabled,onEnter:this.props.onEnter}))},t.prototype.render=function(){return I({props:this.props,state:this.state,control:this.renderControl(),toggleHelp:this.toggleHelp,addOn:this.renderColors()})},t}(i.PureComponent),J=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={showHelp:!1,show:void 0},t.toggleEdit=function(){return t.setState({show:"edit"===t.state.show?void 0:"edit"})},t.togglePresets=function(){return t.setState({show:"presets"===t.state.show?void 0:"presets"})},t.selectPreset=function(e){if(e){t.setState({show:void 0});var r=Object(s.getColorListFromName)(e.value);t.update({kind:"qualitative"!==r.type?"interpolate":"set",colors:r.list})}},t.colorsChanged=function(e){var r=e.value.map((function(e){return[e.color,e.offset]}));r.sort((function(e,t){return e[1]-t[1]})),t.update({kind:t.props.value.kind,colors:r})},t.isInterpolatedChanged=function(e){var r=e.value;t.update({kind:r?"interpolate":"set",colors:t.props.value.colors})},t.toggleHelp=function(){return t.setState({showHelp:!t.state.showHelp})},t}return Object(n.__extends)(t,e),t.prototype.update=function(e){this.props.onChange({param:this.props.param,name:this.props.name,value:e})},t.prototype.renderControl=function(){var e=this.props.value;return i.createElement(i.Fragment,null,i.createElement("button",{onClick:this.toggleEdit,style:{position:"relative",paddingRight:"33px"}},1===e.colors.length?"1 color":e.colors.length+" colors",i.createElement("div",{style:Q(e,"33px")})),i.createElement(m.IconButton,{svg:_.BookmarksOutlinedSvg,onClick:this.togglePresets,toggleState:"presets"===this.state.show,title:"Color Presets",style:{padding:0,position:"absolute",right:0,top:0,width:"32px"}}))},t.prototype.renderColors=function(){if(!this.state.show)return null;var e=K(),t=e.ColorPresets,r=e.OffsetColorsParam,n=e.IsInterpolatedParam,a=t[this.props.param.presetKind];if("presets"===this.state.show)return i.createElement(p.a,{items:a,onSelect:this.selectPreset});var o=this.props.value.colors,s=o.map((function(e,t){return Array.isArray(e)?{color:e[0],offset:e[1]}:{color:e,offset:t/o.length}}));return s.sort((function(e,t){return e.offset-t.offset})),i.createElement("div",{className:"msp-control-offset"},i.createElement(ce,{name:"colors",param:r,value:s,onChange:this.colorsChanged,isDisabled:this.props.isDisabled,onEnter:this.props.onEnter}),i.createElement(k,{name:"isInterpolated",param:n,value:"interpolate"===this.props.value.kind,onChange:this.isInterpolatedChanged,isDisabled:this.props.isDisabled,onEnter:this.props.onEnter}))},t.prototype.render=function(){return I({props:this.props,state:this.state,control:this.renderControl(),toggleHelp:this.toggleHelp,addOn:this.renderColors()})},t}(i.PureComponent),$=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={isExpanded:!1},t.components={0:l.ParamDefinition.Numeric(0,{step:t.props.param.step},{label:t.props.param.fieldLabels&&t.props.param.fieldLabels.x||"X"}),1:l.ParamDefinition.Numeric(0,{step:t.props.param.step},{label:t.props.param.fieldLabels&&t.props.param.fieldLabels.y||"Y"}),2:l.ParamDefinition.Numeric(0,{step:t.props.param.step},{label:t.props.param.fieldLabels&&t.props.param.fieldLabels.z||"Z"})},t.componentChange=function(e){var r=e.name,n=e.value,i=a.Vec3.copy(a.Vec3.zero(),t.props.value);i[+r]=n,t.change(i)},t.toggleExpanded=function(e){t.setState({isExpanded:!t.state.isExpanded}),e.currentTarget.blur()},t}return Object(n.__extends)(t,e),t.prototype.change=function(e){this.props.onChange({name:this.props.name,param:this.props.param,value:e})},t.prototype.render=function(){var e=this.props.value,t=this.props.param.label||Object(d.a)(this.props.name),r=Object(c.b)(this.props.param.step||.01),n="["+e[0].toFixed(r)+", "+e[1].toFixed(r)+", "+e[2].toFixed(r)+"]";return i.createElement(i.Fragment,null,i.createElement(m.ControlRow,{label:t,control:i.createElement("button",{onClick:this.toggleExpanded,disabled:this.props.isDisabled},n)}),this.state.isExpanded&&i.createElement("div",{className:"msp-control-offset"},i.createElement(P,{params:this.components,values:e,onChange:this.componentChange,onEnter:this.props.onEnter})))},t}(i.PureComponent),ee=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={isExpanded:!1},t.components={json:l.ParamDefinition.Text(JSON.stringify(Object(a.Mat4)()),{description:"JSON array with 4x4 matrix in a column major (j * 4 + i indexing) format"})},t.componentChange=function(e){var r=e.name,n=e.value,i=a.Mat4.copy(Object(a.Mat4)(),t.props.value);"json"===r?a.Mat4.copy(i,JSON.parse(n)):i[+r]=n,t.change(i)},t.toggleExpanded=function(e){t.setState({isExpanded:!t.state.isExpanded}),e.currentTarget.blur()},t}return Object(n.__extends)(t,e),t.prototype.change=function(e){this.props.onChange({name:this.props.name,param:this.props.param,value:e})},t.prototype.changeValue=function(e){var t=this;return function(r){var n=a.Mat4.copy(Object(a.Mat4)(),t.props.value);n[e]=r,t.change(n)}},Object.defineProperty(t.prototype,"grid",{get:function(){for(var e=this.props.value,t=[],r=0;r<4;r++){for(var n=[],o=0;o<4;o++)n.push(i.createElement(m.TextInput,{key:o,numeric:!0,delayMs:50,value:a.Mat4.getValue(e,r,o),onChange:this.changeValue(4*o+r),className:"msp-form-control",blurOnEnter:!0,isDisabled:this.props.isDisabled}));t.push(i.createElement("div",{className:"msp-flex-row",key:r},n))}return i.createElement("div",{className:"msp-parameter-matrix"},t)},enumerable:!1,configurable:!0}),t.prototype.render=function(){var e={json:JSON.stringify(this.props.value)},t=this.props.param.label||Object(d.a)(this.props.name);return i.createElement(i.Fragment,null,i.createElement(m.ControlRow,{label:t,control:i.createElement("button",{onClick:this.toggleExpanded,disabled:this.props.isDisabled},"4×4 Matrix")}),this.state.isExpanded&&i.createElement("div",{className:"msp-control-offset"},this.grid,i.createElement(P,{params:this.components,values:e,onChange:this.componentChange,onEnter:this.props.onEnter})))},t}(i.PureComponent),te=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.onChange=function(e){var r=e.target.value;r!==j.Asset.getUrl(t.props.value||"")&&t.update(j.Asset.Url(r))},t.onKeyPress=function(e){13!==e.keyCode&&13!==e.charCode&&"Enter"!==e.key||t.props.onEnter&&t.props.onEnter(),e.stopPropagation()},t}return Object(n.__extends)(t,e),t.prototype.renderControl=function(){var e=this.props.param.label||Object(d.a)(this.props.name);return i.createElement("input",{type:"text",value:j.Asset.getUrl(this.props.value||""),placeholder:e,onChange:this.onChange,onKeyPress:this.props.onEnter?this.onKeyPress:void 0,disabled:this.props.isDisabled})},t}(M),re=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={showHelp:!1},t.onChangeFile=function(e){t.change(e.target.files[0])},t.toggleHelp=function(){return t.setState({showHelp:!t.state.showHelp})},t}return Object(n.__extends)(t,e),t.prototype.change=function(e){this.props.onChange({name:this.props.name,param:this.props.param,value:j.Asset.File(e)})},t.prototype.renderControl=function(){var e=this.props.value;return i.createElement("div",{className:"msp-btn msp-btn-block msp-btn-action msp-loader-msp-btn-file",style:{marginTop:"1px"}},e?e.name:"Select a file..."," ",i.createElement("input",{disabled:this.props.isDisabled,onChange:this.onChangeFile,type:"file",multiple:!1,accept:this.props.param.accept}))},t.prototype.render=function(){return this.props.param.label?I({props:this.props,state:this.state,control:this.renderControl(),toggleHelp:this.toggleHelp,addOn:null}):this.renderControl()},t}(i.PureComponent),ne=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={showHelp:!1},t.onChangeFileList=function(e){t.change(e.target.files)},t.toggleHelp=function(){return t.setState({showHelp:!t.state.showHelp})},t}return Object(n.__extends)(t,e),t.prototype.change=function(e){var t=[];if(e)for(var r=0,n=e.length;r<n;++r)t.push(j.Asset.File(e[r]));this.props.onChange({name:this.props.name,param:this.props.param,value:t})},t.prototype.renderControl=function(){var e=this.props.value,t=[];if(e)for(var r=0,n=e;r<n.length;r++){var a=n[r];t.push(a.name)}var o=0===t.length?"Select files...":1===t.length?t[0]:t.length+" files selected";return i.createElement("div",{className:"msp-btn msp-btn-block msp-btn-action msp-loader-msp-btn-file",style:{marginTop:"1px"}},o," ",i.createElement("input",{disabled:this.props.isDisabled,onChange:this.onChangeFileList,type:"file",multiple:!0,accept:this.props.param.accept}))},t.prototype.render=function(){return this.props.param.label?I({props:this.props,state:this.state,control:this.renderControl(),toggleHelp:this.toggleHelp,addOn:null}):this.renderControl()},t}(i.PureComponent),ie=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={isExpanded:!1},t.toggleExpanded=function(e){t.setState({isExpanded:!t.state.isExpanded}),e.currentTarget.blur()},t}return Object(n.__extends)(t,e),t.prototype.change=function(e){this.props.onChange({name:this.props.name,param:this.props.param,value:e})},t.prototype.toggle=function(e){var t=this;return function(r){t.props.value.indexOf(e)<0?t.change(t.props.value.concat(e)):t.change(t.props.value.filter((function(t){return t!==e}))),r.currentTarget.blur()}},t.prototype.render=function(){var e=this,t=this.props.value,r=this.props.param.emptyValue,n=this.props.param.label||Object(d.a)(this.props.name);return i.createElement(i.Fragment,null,i.createElement(m.ControlRow,{label:n,control:i.createElement("button",{onClick:this.toggleExpanded,disabled:this.props.isDisabled},0===t.length&&r?r:t.length+" of "+this.props.param.options.length)}),this.state.isExpanded&&i.createElement("div",{className:"msp-control-offset"},this.props.param.options.map((function(r){var n=r[0],a=r[1],o=t.indexOf(n)>=0;return i.createElement(m.Button,{key:n,onClick:e.toggle(n),disabled:e.props.isDisabled,style:{marginTop:"1px"}},i.createElement("span",{style:{float:o?"left":"right"}},o?"✓ "+a:a+" ✗"))}))))},t}(i.PureComponent),ae=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={isExpanded:!!t.props.param.isExpanded,showHelp:!1},t.onChangeParam=function(e){var r;t.change(Object(n.__assign)(Object(n.__assign)({},t.props.value),((r={})[e.name]=e.value,r)))},t.toggleExpanded=function(){return t.setState({isExpanded:!t.state.isExpanded})},t}return Object(n.__extends)(t,e),t.prototype.change=function(e){this.props.onChange({name:this.props.name,param:this.props.param,value:e})},t.prototype.pivoted=function(){var e=this.props.param.pivot,t=this.props.param.params,r=t[e],n=D(r),a=i.createElement(n,{name:e,param:r,value:this.props.value[e],onChange:this.onChangeParam,onEnter:this.props.onEnter,isDisabled:this.props.isDisabled});if(!this.state.isExpanded)return i.createElement("div",{className:"msp-mapped-parameter-group"},a,i.createElement(m.IconButton,{svg:_.MoreHorizSvg,onClick:this.toggleExpanded,toggleState:this.state.isExpanded,title:"More Options"}));for(var o=Object.create(null),s=0,u=Object.keys(t);s<u.length;s++){var c=u[s];c!==e&&(o[c]=t[c])}return i.createElement("div",{className:"msp-mapped-parameter-group"},a,i.createElement(m.IconButton,{svg:_.MoreHorizSvg,onClick:this.toggleExpanded,toggleState:this.state.isExpanded,title:"More Options"}),i.createElement("div",{className:"msp-control-offset"},i.createElement(P,{params:o,onEnter:this.props.onEnter,values:this.props.value,onChange:this.onChangeParam,isDisabled:this.props.isDisabled})))},t.prototype.render=function(){var e=this.props.param.params;if(0===Object.keys(e).length)return null;if(this.props.param.pivot)return this.pivoted();var t=this.props.param.label||Object(d.a)(this.props.name),r=i.createElement(P,{params:e,onChange:this.onChangeParam,values:this.props.value,onEnter:this.props.onEnter,isDisabled:this.props.isDisabled});return this.props.inMapped?i.createElement("div",{className:"msp-control-offset"},r):this.props.param.isFlat?r:i.createElement("div",{className:"msp-control-group-wrapper"},i.createElement("div",{className:"msp-control-group-header"},i.createElement("button",{className:"msp-btn msp-form-control msp-btn-block",onClick:this.toggleExpanded},i.createElement(_.Icon,{svg:this.state.isExpanded?_.ArrowDropDownSvg:_.ArrowRightSvg}),t)),this.state.isExpanded&&i.createElement("div",{className:"msp-control-offset"},r))},t}(i.PureComponent),oe=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={isExpanded:!1},t.valuesCache={},t.onChangeName=function(e){t.change({name:e.value,params:t.getValues(e.value)})},t.onChangeParam=function(e){t.setValues(t.props.value.name,e.value),t.change({name:t.props.value.name,params:e.value})},t.toggleExpanded=function(){return t.setState({isExpanded:!t.state.isExpanded})},t}return Object(n.__extends)(t,e),t.prototype.setValues=function(e,t){this.valuesCache[e]=t},t.prototype.getValues=function(e){return e in this.valuesCache?this.valuesCache[e]:this.props.param.map(e).defaultValue},t.prototype.change=function(e){this.props.onChange({name:this.props.name,param:this.props.param,value:e})},t.prototype.areParamsEmpty=function(e){for(var t=0,r=Object.keys(e);t<r.length;t++){if(!e[r[t]].isHidden)return!1}return!0},t.prototype.render=function(){var e=this,t=this.props.value||this.props.param.defaultValue,r=this.props.param.map(t.name),a=this.props.param.label||Object(d.a)(this.props.name),o=D(r),s=this.props.param.help,u=s?Object(n.__assign)(Object(n.__assign)({},this.props.param.select),{help:function(t){return s({name:t,params:e.getValues(t)})}}):this.props.param.select,c=i.createElement(F,{param:u,isDisabled:this.props.isDisabled,onChange:this.onChangeName,onEnter:this.props.onEnter,name:a,value:t.name});return o?"group"!==r.type||r.isFlat?i.createElement(i.Fragment,null,c,i.createElement(o,{param:r,value:t.params,name:t.name,onChange:this.onChangeParam,onEnter:this.props.onEnter,isDisabled:this.props.isDisabled})):this.areParamsEmpty(r.params)?c:i.createElement("div",{className:"msp-mapped-parameter-group"},c,i.createElement(m.IconButton,{svg:_.MoreHorizSvg,onClick:this.toggleExpanded,toggleState:this.state.isExpanded,title:a+" Properties"}),this.state.isExpanded&&i.createElement(ae,{inMapped:!0,param:r,value:t.params,name:t.name,onChange:this.onChangeParam,onEnter:this.props.onEnter,isDisabled:this.props.isDisabled})):c},t}(i.PureComponent),se=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={current:t.props.value},t.onChangeParam=function(e){var r;t.setState({current:Object(n.__assign)(Object(n.__assign)({},t.state.current),(r={},r[e.name]=e.value,r))})},t.apply=function(){t.props.apply(t.state.current)},t}return Object(n.__extends)(t,e),t.prototype.componentDidUpdate=function(e){this.props.params===e.params&&this.props.value===e.value||this.setState({current:this.props.value})},t.prototype.render=function(){return i.createElement(i.Fragment,null,i.createElement(P,{params:this.props.params,onChange:this.onChangeParam,values:this.state.current,onEnter:this.apply,isDisabled:this.props.isDisabled}),i.createElement("button",{className:"msp-btn msp-btn-block msp-form-control msp-control-top-offset",onClick:this.apply,disabled:this.props.isDisabled},this.props.isUpdate?"Update":"Add"))},t}(i.PureComponent),ue=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={isExpanded:!1},t.update=function(e){t.props.actions.update(e,t.props.index)},t.moveUp=function(){t.props.actions.move(t.props.index,-1)},t.moveDown=function(){t.props.actions.move(t.props.index,1)},t.remove=function(){t.setState({isExpanded:!1}),t.props.actions.remove(t.props.index)},t.toggleExpanded=function(e){t.setState({isExpanded:!t.state.isExpanded}),e.currentTarget.blur()},t}return Object(n.__extends)(t,e),t.prototype.render=function(){return i.createElement(i.Fragment,null,i.createElement("div",{className:"msp-param-object-list-item"},i.createElement("button",{className:"msp-btn msp-btn-block msp-form-control",onClick:this.toggleExpanded},i.createElement("span",null,this.props.index+1+": "),this.props.param.getLabel(this.props.value)),i.createElement("div",null,i.createElement(m.IconButton,{svg:_.ArrowDownwardSvg,title:"Move Up",onClick:this.moveUp,small:!0}),i.createElement(m.IconButton,{svg:_.ArrowUpwardSvg,title:"Move Down",onClick:this.moveDown,small:!0}),i.createElement(m.IconButton,{svg:_.DeleteOutlinedSvg,title:"Remove",onClick:this.remove,small:!0}))),this.state.isExpanded&&i.createElement("div",{className:"msp-control-offset"},i.createElement(se,{params:this.props.param.element,apply:this.update,value:this.props.value,isUpdate:!0,isDisabled:this.props.isDisabled})))},t}(i.PureComponent),ce=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={isExpanded:!1},t.add=function(e){t.change(Object(n.__spreadArrays)(t.props.value,[e]))},t.actions={update:function(e,r){var n=t.props.value.slice(0);n[r]=e,t.change(n)},move:function(e,r){var n=t.props.value;if(1!==n.length){var i=(e+r)%n.length;i<0&&(i+=n.length);var a=(n=n.slice(0))[e];n[e]=n[i],n[i]=a,t.change(n)}},remove:function(e){for(var r=t.props.value,n=[],i=0;i<r.length;i++)e!==i&&n.push(r[i]);t.change(n)}},t.toggleExpanded=function(e){t.setState({isExpanded:!t.state.isExpanded}),e.currentTarget.blur()},t}return Object(n.__extends)(t,e),t.prototype.change=function(e){this.props.onChange({name:this.props.name,param:this.props.param,value:e})},t.prototype.render=function(){var e=this,t=this.props.value,r=this.props.param.label||Object(d.a)(this.props.name),n=t.length+" item"+(1!==t.length?"s":"");return i.createElement(i.Fragment,null,i.createElement(m.ControlRow,{label:r,control:i.createElement("button",{onClick:this.toggleExpanded,disabled:this.props.isDisabled},n)}),this.state.isExpanded&&i.createElement("div",{className:"msp-control-offset"},this.props.value.map((function(t,r){return i.createElement(ue,{key:r,param:e.props.param,value:t,index:r,actions:e.actions,isDisabled:e.props.isDisabled})})),i.createElement(m.ControlGroup,{header:"New Item"},i.createElement(se,{params:this.props.param.element,apply:this.add,value:this.props.param.ctor(),isDisabled:this.props.isDisabled}))))},t}(i.PureComponent),le=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return 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diverging color scheme from ColorBrewer 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t[r+0]=e[0],t[r+1]=e[1],t[r+2]=e[2],t[r+3]=e[3],t[r+4]=e[4],t[r+5]=e[5],t[r+6]=e[6],t[r+7]=e[7],t[r+8]=e[8],t[r+9]=e[9],t[r+10]=e[10],t[r+11]=e[11],t[r+12]=e[12],t[r+13]=e[13],t[r+14]=e[14],t[r+15]=e[15],t},e.fromArray=function(e,t,r){return e[0]=t[r+0],e[1]=t[r+1],e[2]=t[r+2],e[3]=t[r+3],e[4]=t[r+4],e[5]=t[r+5],e[6]=t[r+6],e[7]=t[r+7],e[8]=t[r+8],e[9]=t[r+9],e[10]=t[r+10],e[11]=t[r+11],e[12]=t[r+12],e[13]=t[r+13],e[14]=t[r+14],e[15]=t[r+15],e},e.fromBasis=function(t,r,n,i){return e.setZero(t),e.setValue(t,0,0,r[0]),e.setValue(t,1,0,r[1]),e.setValue(t,2,0,r[2]),e.setValue(t,0,1,n[0]),e.setValue(t,1,1,n[1]),e.setValue(t,2,1,n[2]),e.setValue(t,0,2,i[0]),e.setValue(t,1,2,i[1]),e.setValue(t,2,2,i[2]),e.setValue(t,3,3,1),t},e.copy=function(e,t){return e[0]=t[0],e[1]=t[1],e[2]=t[2],e[3]=t[3],e[4]=t[4],e[5]=t[5],e[6]=t[6],e[7]=t[7],e[8]=t[8],e[9]=t[9],e[10]=t[10],e[11]=t[11],e[12]=t[12],e[13]=t[13],e[14]=t[14],e[15]=t[15],e},e.clone=function(t){return e.copy(e.zero(),t)},e.getTranslation=function(e,t){return e[0]=t[12],e[1]=t[13],e[2]=t[14],e},e.getScaling=function(e,t){var r=t[0],n=t[1],i=t[2],a=t[4],o=t[5],s=t[6],u=t[8],c=t[9],l=t[10];return e[0]=Math.sqrt(r*r+n*n+i*i),e[1]=Math.sqrt(a*a+o*o+s*s),e[2]=Math.sqrt(u*u+c*c+l*l),e},e.getRotation=function(e,t){var r=t[0]+t[5]+t[10],n=0;return r>0?(n=2*Math.sqrt(r+1),e[3]=.25*n,e[0]=(t[6]-t[9])/n,e[1]=(t[8]-t[2])/n,e[2]=(t[1]-t[4])/n):t[0]>t[5]&&t[0]>t[10]?(n=2*Math.sqrt(1+t[0]-t[5]-t[10]),e[3]=(t[6]-t[9])/n,e[0]=.25*n,e[1]=(t[1]+t[4])/n,e[2]=(t[8]+t[2])/n):t[5]>t[10]?(n=2*Math.sqrt(1+t[5]-t[0]-t[10]),e[3]=(t[8]-t[2])/n,e[0]=(t[1]+t[4])/n,e[1]=.25*n,e[2]=(t[6]+t[9])/n):(n=2*Math.sqrt(1+t[10]-t[0]-t[5]),e[3]=(t[1]-t[4])/n,e[0]=(t[8]+t[2])/n,e[1]=(t[6]+t[9])/n,e[2]=.25*n),e},e.extractRotation=function(e,t){var r=1/Math.sqrt(t[0]*t[0]+t[1]*t[1]+t[2]*t[2]),n=1/Math.sqrt(t[4]*t[4]+t[5]*t[5]+t[6]*t[6]),i=1/Math.sqrt(t[8]*t[8]+t[9]*t[9]+t[10]*t[10]);return e[0]=t[0]*r,e[1]=t[1]*r,e[2]=t[2]*r,e[3]=0,e[4]=t[4]*n,e[5]=t[5]*n,e[6]=t[6]*n,e[7]=0,e[8]=t[8]*i,e[9]=t[9]*i,e[10]=t[10]*i,e[11]=0,e[12]=0,e[13]=0,e[14]=0,e[15]=1,e},e.transpose=function(e,t){if(e===t){var r=t[1],n=t[2],i=t[3],a=t[6],o=t[7],s=t[11];e[1]=t[4],e[2]=t[8],e[3]=t[12],e[4]=r,e[6]=t[9],e[7]=t[13],e[8]=n,e[9]=a,e[11]=t[14],e[12]=i,e[13]=o,e[14]=s}else e[0]=t[0],e[1]=t[4],e[2]=t[8],e[3]=t[12],e[4]=t[1],e[5]=t[5],e[6]=t[9],e[7]=t[13],e[8]=t[2],e[9]=t[6],e[10]=t[10],e[11]=t[14],e[12]=t[3],e[13]=t[7],e[14]=t[11],e[15]=t[15];return e},e.invert=function(e,t){var r=t[0],n=t[1],i=t[2],a=t[3],o=t[4],s=t[5],u=t[6],c=t[7],l=t[8],d=t[9],f=t[10],p=t[11],m=t[12],h=t[13],g=t[14],v=t[15],b=r*s-n*o,y=r*u-i*o,_=r*c-a*o,S=n*u-i*s,x=n*c-a*s,O=i*c-a*u,w=l*h-d*m,C=l*g-f*m,j=l*v-p*m,P=d*g-f*h,E=d*v-p*h,A=f*v-p*g,D=b*A-y*E+_*P+S*j-x*C+O*w;return D?(D=1/D,e[0]=(s*A-u*E+c*P)*D,e[1]=(i*E-n*A-a*P)*D,e[2]=(h*O-g*x+v*S)*D,e[3]=(f*x-d*O-p*S)*D,e[4]=(u*j-o*A-c*C)*D,e[5]=(r*A-i*j+a*C)*D,e[6]=(g*_-m*O-v*y)*D,e[7]=(l*O-f*_+p*y)*D,e[8]=(o*E-s*j+c*w)*D,e[9]=(n*j-r*E-a*w)*D,e[10]=(m*x-h*_+v*b)*D,e[11]=(d*_-l*x-p*b)*D,e[12]=(s*C-o*P-u*w)*D,e[13]=(r*P-n*C+i*w)*D,e[14]=(h*y-m*S-g*b)*D,e[15]=(l*S-d*y+f*b)*D,e):(console.warn("non-invertible matrix.",t),e)},e.mul=d,e.mulOffset=function(e,t,r,n,i,a){var o=t[0+i],s=t[1+i],u=t[2+i],c=t[3+i],l=t[4+i],d=t[5+i],f=t[6+i],p=t[7+i],m=t[8+i],h=t[9+i],g=t[10+i],v=t[11+i],b=t[12+i],y=t[13+i],_=t[14+i],S=t[15+i],x=r[0+a],O=r[1+a],w=r[2+a],C=r[3+a];return e[0+n]=x*o+O*l+w*m+C*b,e[1+n]=x*s+O*d+w*h+C*y,e[2+n]=x*u+O*f+w*g+C*_,e[3+n]=x*c+O*p+w*v+C*S,x=r[4+a],O=r[5+a],w=r[6+a],C=r[7+a],e[4+n]=x*o+O*l+w*m+C*b,e[5+n]=x*s+O*d+w*h+C*y,e[6+n]=x*u+O*f+w*g+C*_,e[7+n]=x*c+O*p+w*v+C*S,x=r[8+a],O=r[9+a],w=r[10+a],C=r[11+a],e[8+n]=x*o+O*l+w*m+C*b,e[9+n]=x*s+O*d+w*h+C*y,e[10+n]=x*u+O*f+w*g+C*_,e[11+n]=x*c+O*p+w*v+C*S,x=r[12+a],O=r[13+a],w=r[14+a],C=r[15+a],e[12+n]=x*o+O*l+w*m+C*b,e[13+n]=x*s+O*d+w*h+C*y,e[14+n]=x*u+O*f+w*g+C*_,e[15+n]=x*c+O*p+w*v+C*S,e},e.mul3=function(e,t,r,n){return d(e,d(e,t,r),n)},e.translate=function(e,t,r){var n,i,a,o,s,u,c,l,d,f,p,m,h=r[0],g=r[1],v=r[2];return t===e?(e[12]=t[0]*h+t[4]*g+t[8]*v+t[12],e[13]=t[1]*h+t[5]*g+t[9]*v+t[13],e[14]=t[2]*h+t[6]*g+t[10]*v+t[14],e[15]=t[3]*h+t[7]*g+t[11]*v+t[15]):(n=t[0],i=t[1],a=t[2],o=t[3],s=t[4],u=t[5],c=t[6],l=t[7],d=t[8],f=t[9],p=t[10],m=t[11],e[0]=n,e[1]=i,e[2]=a,e[3]=o,e[4]=s,e[5]=u,e[6]=c,e[7]=l,e[8]=d,e[9]=f,e[10]=p,e[11]=m,e[12]=n*h+s*g+d*v+t[12],e[13]=i*h+u*g+f*v+t[13],e[14]=a*h+c*g+p*v+t[14],e[15]=o*h+l*g+m*v+t[15]),e},e.fromTranslation=function(e,t){return e[0]=1,e[1]=0,e[2]=0,e[3]=0,e[4]=0,e[5]=1,e[6]=0,e[7]=0,e[8]=0,e[9]=0,e[10]=1,e[11]=0,e[12]=t[0],e[13]=t[1],e[14]=t[2],e[15]=1,e},e.setTranslation=function(e,t){return e[12]=t[0],e[13]=t[1],e[14]=t[2],e},e.setAxes=function(e,t,r,n){return e[0]=r[0],e[4]=r[1],e[8]=r[2],e[1]=n[0],e[5]=n[1],e[9]=n[2],e[2]=t[0],e[6]=t[1],e[10]=t[2],e},e.rotate=function(t,r,i,a){var o,s,u,c,l,d,f,p,m,h,g,v,b,y,_,S,x,O,w,C,j,P,E,A,D=a[0],T=a[1],I=a[2],M=Math.sqrt(D*D+T*T+I*I);return Math.abs(M)<n.a?e.identity():(D*=M=1/M,T*=M,I*=M,o=Math.sin(i),u=1-(s=Math.cos(i)),c=r[0],l=r[1],d=r[2],f=r[3],p=r[4],m=r[5],h=r[6],g=r[7],v=r[8],b=r[9],y=r[10],_=r[11],S=D*D*u+s,x=T*D*u+I*o,O=I*D*u-T*o,w=D*T*u-I*o,C=T*T*u+s,j=I*T*u+D*o,P=D*I*u+T*o,E=T*I*u-D*o,A=I*I*u+s,t[0]=c*S+p*x+v*O,t[1]=l*S+m*x+b*O,t[2]=d*S+h*x+y*O,t[3]=f*S+g*x+_*O,t[4]=c*w+p*C+v*j,t[5]=l*w+m*C+b*j,t[6]=d*w+h*C+y*j,t[7]=f*w+g*C+_*j,t[8]=c*P+p*E+v*A,t[9]=l*P+m*E+b*A,t[10]=d*P+h*E+y*A,t[11]=f*P+g*E+_*A,r!==t&&(t[12]=r[12],t[13]=r[13],t[14]=r[14],t[15]=r[15]),t)},e.fromRotation=function(e,t,r){var i,a,s,u=r[0],c=r[1],l=r[2],d=Math.sqrt(u*u+c*c+l*l);return Math.abs(d)<n.a?o(e):(u*=d=1/d,c*=d,l*=d,i=Math.sin(t),s=1-(a=Math.cos(t)),e[0]=u*u*s+a,e[1]=c*u*s+l*i,e[2]=l*u*s-c*i,e[3]=0,e[4]=u*c*s-l*i,e[5]=c*c*s+a,e[6]=l*c*s+u*i,e[7]=0,e[8]=u*l*s+c*i,e[9]=c*l*s-u*i,e[10]=l*l*s+a,e[11]=0,e[12]=0,e[13]=0,e[14]=0,e[15]=1,e)},e.scale=function(e,t,r){var n=r[0],i=r[1],a=r[2];return e[0]=t[0]*n,e[1]=t[1]*n,e[2]=t[2]*n,e[3]=t[3]*n,e[4]=t[4]*i,e[5]=t[5]*i,e[6]=t[6]*i,e[7]=t[7]*i,e[8]=t[8]*a,e[9]=t[9]*a,e[10]=t[10]*a,e[11]=t[11]*a,e[12]=t[12],e[13]=t[13],e[14]=t[14],e[15]=t[15],e},e.scaleUniformly=function(e,t,r){return e[0]=t[0]*r,e[1]=t[1]*r,e[2]=t[2]*r,e[3]=t[3]*r,e[4]=t[4]*r,e[5]=t[5]*r,e[6]=t[6]*r,e[7]=t[7]*r,e[8]=t[8]*r,e[9]=t[9]*r,e[10]=t[10]*r,e[11]=t[11]*r,e[12]=t[12],e[13]=t[13],e[14]=t[14],e[15]=t[15],e},e.fromScaling=function(e,t){return e[0]=t[0],e[1]=0,e[2]=0,e[3]=0,e[4]=0,e[5]=t[1],e[6]=0,e[7]=0,e[8]=0,e[9]=0,e[10]=t[2],e[11]=0,e[12]=0,e[13]=0,e[14]=0,e[15]=1,e},e.fromUniformScaling=function(e,t){return e[0]=t,e[1]=0,e[2]=0,e[3]=0,e[4]=0,e[5]=t,e[6]=0,e[7]=0,e[8]=0,e[9]=0,e[10]=t,e[11]=0,e[12]=0,e[13]=0,e[14]=0,e[15]=1,e},e.fromMat3=function(e,t){return e[0]=t[0],e[1]=t[1],e[2]=t[2],e[4]=t[3],e[5]=t[4],e[6]=t[5],e[8]=t[6],e[9]=t[7],e[10]=t[8],e},e.makeTable=function(e){for(var t="",r=0;r<4;r++){for(var n=0;n<4;n++)t+=e[4*n+r].toString(),n<3&&(t+=" 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c=a[o.indices[s]];p.Vec3.set(this.pivot,e,t,r),c.conformation.operator.isIdentity||p.Vec3.transformMat4(this.pivot,this.pivot,c.conformation.operator.inverse);var l=c.lookup3d.find(this.pivot[0],this.pivot[1],this.pivot[2],n);if(0!==l.count){var d=c.elements;i.beginUnit(c.id);for(var f=0,m=l.count;f<m;f++)i.addElement(d[l.indices[f]]);i.commitUnit()}}},e.prototype.findIntoBuilderWithRadius=function(e,t,r,n,i,a,o,s){var u=this.structure.units,c=this.unitLookup.find(e,t,r,a);if(0!==c.count)for(var d=l.a.Location.create(this.structure),f=n+i+a,m=0,h=c.count;m<h;m++){var g=u[c.indices[m]];p.Vec3.set(this.pivot,e,t,r),g.conformation.operator.isIdentity||p.Vec3.transformMat4(this.pivot,this.pivot,g.conformation.operator.inverse);var v=g.lookup3d.find(this.pivot[0],this.pivot[1],this.pivot[2],f);if(0!==v.count){var b=g.elements;d.unit=g,s.beginUnit(g.id);for(var y=0,_=v.count;y<_;y++){d.element=b[v.indices[y]];var S=o(d);Math.sqrt(v.squaredDistances[y])-n-S>a||s.addElement(b[v.indices[y]])}s.commitUnit()}}},e.prototype.check=function(e,t,r,n){var i=this.structure.units,a=this.unitLookup.find(e,t,r,n);if(0===a.count)return!1;for(var o=0,s=a.count;o<s;o++){var u=i[a.indices[o]];if(p.Vec3.set(this.pivot,e,t,r),u.conformation.operator.isIdentity||p.Vec3.transformMat4(this.pivot,this.pivot,u.conformation.operator.inverse),u.lookup3d.check(this.pivot[0],this.pivot[1],this.pivot[2],n))return!0}return!1},Object.defineProperty(e.prototype,"boundary",{get:function(){return this.structure.boundary},enumerable:!1,configurable:!0}),e}(),h=r(251),g=function(){function e(e,t){this.parent=e,this.isSorted=t,this.ids=[],this.unitMap=a.IntMap.Mutable(),this.parentId=-1,this.currentUnit=[],this.elementCount=0}return e.prototype.addToUnit=function(e,t){var r=this.unitMap.get(e);r?r[r.length]=t:(this.unitMap.set(e,[t]),this.ids[this.ids.length]=e),this.elementCount++},e.prototype.beginUnit=function(e){this.parentId=e,this.currentUnit=this.currentUnit.length>0?[]:this.currentUnit},e.prototype.addElement=function(e){this.currentUnit[this.currentUnit.length]=e,this.elementCount++},e.prototype.addElementRange=function(e,t,r){for(var n=t;n<r;n++)this.currentUnit[this.currentUnit.length]=e[n],this.elementCount++},e.prototype.commitUnit=function(){0!==this.currentUnit.length&&(this.ids[this.ids.length]=this.parentId,this.unitMap.set(this.parentId,this.currentUnit),this.parentId=-1)},e.prototype.setUnit=function(e,t){this.ids[this.ids.length]=e,this.unitMap.set(e,t),this.elementCount+=t.length},e.prototype._getStructure=function(e){if(this.isEmpty)return $.Empty;var t=[];Object(c.q)(this.ids);for(var r=h.a.UnitEquivalenceBuilder(),n=0,i=this.ids.length;n<i;n++){var o=this.ids[n],s=this.parent.unitMap.get(o),u=this.unitMap.get(o),l=!1;e&&(this.isSorted||Object(c.q)(u),u=a.SortedArray.deduplicate(a.SortedArray.ofSortedArray(this.currentUnit)),l=!0);var d=u.length;if(u.length!==s.elements.length){!this.isSorted&&!l&&d>1&&Object(c.q)(u);var f=s.getChild(a.SortedArray.ofSortedArray(u)),p=r.add(f.id,f);f!==p&&(f=p.applyOperator(f.id,f.conformation.operator,!0)),t[t.length]=f}else t[t.length]=s,r.add(s.id,s)}return $.create(t,{parent:this.parent})},e.prototype.getStructure=function(){return this._getStructure(!1)},e.prototype.getStructureDeduplicate=function(){return this._getStructure(!0)},e.prototype.setSingletonLocation=function(e){var t=this.ids[0];e.unit=this.parent.unitMap.get(t),e.element=this.unitMap.get(t)[0]},Object.defineProperty(e.prototype,"isEmpty",{get:function(){return 0===this.elementCount},enumerable:!1,configurable:!0}),e}(),v=r(163),b=r(176);function y(e,t){for(var r=1;t--;)r*=e--;return r}var _=function(){function e(e,t){var r,n;this.array=e,this.hasNext=!1,this.index=(1<<t)-1,this.size=(r=e.length,(n=t)>r?0:y(r,n)/y(n,n)),this.maxIndex=1<<e.length,this.value=new Array(t),this.hasNext=t>0&&t<=e.length}return e.prototype.move=function(){if(this.hasNext){for(var e=0,t=0,r=this.index;r;r>>>=1,e++)1&r&&(this.value[t++]=this.array[e]);this.index=function(e){var t=e&-e,r=e+t;return r|((r&-r)/t>>1)-1}(this.index),this.hasNext=this.index<this.maxIndex}return this.value},e}();function S(e,t){for(var r=[],n=new _(e,t);n.hasNext;)r.push(n.move().slice());return r}var x=r(145),O=r(238),w=r(29),C=r(22),j=r(150),P=[],E={links:P,terminalLinks:P,elements:P,partialElements:P,getElementIndices:function(){return P},getLinkIndices:function(){return P},getTerminalLinkIndices:function(){return P}},A=r(209),D=Object(C.ElementSymbol)("C"),T=Object(C.ElementSymbol)("O"),I=[A.a.elementFingerprint([D,D,D,T]),A.a.elementFingerprint([D,D,D,D,T]),A.a.elementFingerprint([D,D,D,D,D,T]),A.a.elementFingerprint([D,D,D,D,D,D,T])];function M(e,t){for(var r=-1,n=-1,i=-1,a=-1,o=e.elements,s=e.model.atomicHierarchy.atoms,u=s.type_symbol,c=s.label_atom_id,l=e.bonds,d=l.b,f=l.offset,p=0,m=t.length;p<m;++p){var h=o[t[p]];if(u.value(h)===D){for(var g=0,v=0,b=f[t[p]],y=f[t[p]+1];b<y;++b){var _=o[d[b]],S=u.value(_);S===T?++g:S===D&&++v}if(2===g){r=h;break}1===g&&1===v?n=h:c.value(h).startsWith("C1")?i=h:a=h}}return-1!==r?r:-1!==n?n:-1!==i?i:-1!==a?a:o[t[0]]}function k(e,t,r,n){var i=t.conformation.position;return p.Vec3.normalize(e,p.Vec3.sub(e,n,i(r,e))),e}function B(e,t){var r=e.elements;return e.model.atomicHierarchy.atoms.label_atom_id.value(r[t])}function V(e,t){if(t&&t.length){for(var r=e.unit,n=e.all,i=new Set,o=S(Object(w.fillSerial)(new Array(t.length)),2),s=0,u=o.length;s<u;++s){var c=o[s],l=n[t[c[0]]],d=n[t[c[1]]];a.SortedArray.areIntersecting(l,d)&&A.a.getAltId(r,l)===A.a.getAltId(r,d)&&(i.add(t[c[0]]),i.add(t[c[1]]))}if(i.size){var f=[];for(s=0,u=t.length;s<u;++s)i.has(t[s])||f.push(t[s]);return f}return t}}function R(e,t){return t.properties.saccharideComponentMap.get(e)}function L(e){if(0===e.models.reduce((function(e,t){return e+t.properties.saccharideComponentMap.size}),0))return E;var t=[],r=[],n=[],o=[],s=new Map;function u(e,t,r){return e+"|"+t+"|"+r}function l(e,t){s.has(e)?s.get(e).push(t):s.set(e,[t])}function f(e,t){p.Vec3.sub(n[e].geometry.direction,n[t].geometry.center,n[e].geometry.center),p.Vec3.normalize(n[e].geometry.direction,n[e].geometry.direction)}var m=p.Vec3.zero();function h(e,t,r){var i=r.conformation.position,a=n[e].geometry;p.Vec3.sub(a.direction,i(r.elements[t],m),a.center),p.Vec3.normalize(a.direction,a.direction)}for(var g=0,v=e.units.length;g<v;++g){var b=e.units[g];if(d.a.isAtomic(b))for(var y=b.model,_=b.rings,P=y.atomicHierarchy,D=P.chainAtomSegments,T=P.residueAtomSegments,L=P.atoms.label_comp_id,N=a.Segmentation.transientSegments(D,b.elements),F=a.Segmentation.transientSegments(T,b.elements),U=void 0;N.hasNext;)for(F.setSegment(N.move());F.hasNext;){var z=F.move().index,H=R(L.value(T.offsets[z]),y);if(H){U||(U=A.b.byFingerprintAndResidue(_,I));var G=V(_,U.get(z));if(G&&G.length){for(var q=[],W=0,X=G.length;W<X;++W){var Y=_.all[G[W]],Q=M(b,Y),K=O.a.calculateMomentsAxes(Object(j.c)(b,Y)),Z=p.Vec3.copy(p.Vec3.zero(),K.origin),J=p.Vec3.copy(p.Vec3.zero(),K.dirC),$=k(p.Vec3.zero(),b,Q,Z);p.Vec3.orthogonalize($,J,$);var ee=A.a.getAltId(b,Y),te=n.length;q.push(te),l(u(z,b.id,ee),te),ee&&l(u(z,b.id,""),te),n.push({geometry:{center:Z,normal:J,direction:$},component:H,ringIndex:G[W],altId:ee,unit:b,residueIndex:z})}var re=S(Object(w.fillSerial)(new Array(G.length)),2);for(W=0,X=re.length;W<X;++W){var ne=re[W],ie=_.all[G[ne[0]]],ae=_.all[G[ne[1]]];if(x.a.areVertexSetsConnected(b.bonds,ie,ae,3)){var oe=q[ne[0]],se=q[ne[1]];n[oe].altId===n[se].altId&&(f(oe,se),f(se,oe),t.push({carbohydrateIndexA:oe,carbohydrateIndexB:se}),t.push({carbohydrateIndexA:se,carbohydrateIndexB:oe}))}}}else o.push({unit:b,residueIndex:z,component:H})}}}function ue(e,t){return s.get(u(e.getResidueIndex(t),e.id,function(e,t){var r=e.elements;return e.model.atomicHierarchy.atoms.label_alt_id.value(r[t])}(e,t)))||[]}for(g=0,v=n.length;g<v;++g){var ce=n[g];for(b=ce.unit,W=g+1;W<v;++W){var le=n[W];if(b===le.unit&&ce.residueIndex!==le.residueIndex){var de=b.rings.all[ce.ringIndex],fe=b.rings.all[le.ringIndex];x.a.areVertexSetsConnected(b.bonds,de,fe,3)&&(f(g,W),f(W,g),t.push({carbohydrateIndexA:g,carbohydrateIndexB:W}),t.push({carbohydrateIndexA:W,carbohydrateIndexB:g}))}}}for(g=0,v=e.units.length;g<v;++g){b=e.units[g];d.a.isAtomic(b)&&e.interUnitBonds.getConnectedUnits(b.id).forEach((function(n){n.connectedIndices.forEach((function(i){n.getEdges(i).forEach((function(a){var o=a.props,s=a.indexB;if(C.BondType.isCovalent(o.flag)){var u=e.unitMap.get(n.unitA),c=e.unitMap.get(n.unitB),l=ue(u,i),d=ue(c,s);if(l.length>0&&d.length>0)for(var p=l.length,m=d.length,g=0,v=Math.max(p,m);g<v;++g){var b=l[Math.min(g,p-1)],y=d[Math.min(g,m-1)];((x=B(u,i)).startsWith("O1")||x.startsWith("C1"))&&f(b,y),t.push({carbohydrateIndexA:b,carbohydrateIndexB:y})}else if(0===d.length)for(var _=0,S=l;_<S.length;_++){var x;b=S[_];((x=B(u,i)).startsWith("O1")||x.startsWith("C1"))&&h(b,s,c),r.push({carbohydrateIndex:b,elementIndex:s,elementUnit:c,fromCarbohydrate:!0})}else if(0===l.length)for(var O=0,w=d;O<w.length;O++){y=w[O];r.push({carbohydrateIndex:y,elementIndex:i,elementUnit:u,fromCarbohydrate:!1})}}}))}))}))}return Object(i.__assign)({links:t,terminalLinks:r,elements:n,partialElements:o},function(e,t,r){function n(e,t){return Object(c.f)(e.id,t)}function i(e,t,r){var i=[],a=e.get(n(t,r));if(void 0!==a)for(var o=0,s=a;o<s.length;o++){var u=s[o];Object(w.arraySetAdd)(i,u)}return i}for(var a=new Map,o=0,s=e.length;o<s;++o)for(var u=e[o],l=u.unit,d=u.ringIndex,f=l.rings.all[d],p=0,m=f.length;p<m;++p){var h=n(l,l.elements[f[p]]);void 0===(P=a.get(h))?a.set(h,[o]):P.push(o)}var g=new Map;for(o=0,s=t.length;o<s;++o){var v=t[o],b=e[v.carbohydrateIndexA];for(l=b.unit,d=b.ringIndex,f=l.rings.all[d],p=0,m=f.length;p<m;++p){h=n(l,l.elements[f[p]]);void 0===(P=g.get(h))?g.set(h,[o]):P.push(o)}}var y=new Map;for(o=0,s=r.length;o<s;++o){var _=r[o],S=_.fromCarbohydrate,x=_.carbohydrateIndex,O=_.elementUnit,C=_.elementIndex;if(S){var j=e[x];for(l=j.unit,d=j.ringIndex,f=l.rings.all[d],p=0,m=f.length;p<m;++p){h=n(l,l.elements[f[p]]);void 0===(P=y.get(h))?y.set(h,[o]):P.push(o)}}else{var P;h=n(O,O.elements[C]);void 0===(P=y.get(h))?y.set(h,[o]):P.push(o)}}return{getElementIndices:function(e,t){return i(a,e,t)},getLinkIndices:function(e,t){return i(g,e,t)},getTerminalLinkIndices:function(e,t){return i(y,e,t)}}}(n,t,r))}var N=r(99),F=r(66),U=r(120),z=r(39),H=(r(203),r(212)),G=r(17),q=r(128),W=Object(f.g)(),X=new q.a("14"),Y=new q.a("98");function Q(e){var t=e.units,r=t.length>500?X:Y;r.reset();for(var n=0,i=t.length;n<i;n++){var a=(o=t[n]).boundary;(s=o.conformation.operator).isIdentity?r.includeSphere(a.sphere):(f.g.transform(W,a.sphere,s.matrix),r.includeSphere(W))}r.finishedIncludeStep();for(n=0,i=t.length;n<i;n++){var o,s;a=(o=t[n]).boundary;(s=o.conformation.operator).isIdentity?r.radiusSphere(a.sphere):(f.g.transform(W,a.sphere,s.matrix),r.radiusSphere(W))}return{box:r.getBox(),sphere:r.getSphere()}}var K=function(){function e(e,t){void 0===t&&(t={}),this._props={hashCode:-1,transformHash:-1,elementCount:-1,bondCount:-1,uniqueElementCount:-1,atomicResidueCount:-1,polymerResidueCount:-1,polymerUnitCount:-1,coordinateSystem:s.a.Default,label:""};var r=this.initUnits(e),n=r.unitMap,i=r.unitIndexMap;this.unitMap=n,this.unitIndexMap=i,this.units=e,t.parent&&(this._props.parent=t.parent.parent||t.parent),t.interUnitBonds&&(this._props.interUnitBonds=t.interUnitBonds),t.coordinateSystem?this._props.coordinateSystem=t.coordinateSystem:t.parent&&(this._props.coordinateSystem=t.parent.coordinateSystem),t.label?this._props.label=t.label:t.parent&&(this._props.label=t.parent.label),t.masterModel?this._props.masterModel=t.masterModel:t.parent&&(this._props.masterModel=t.parent.masterModel),t.representativeModel?this._props.representativeModel=t.representativeModel:t.parent&&(this._props.representativeModel=t.parent.representativeModel)}return e.prototype.subsetBuilder=function(e){return new g(this,e)},Object.defineProperty(e.prototype,"elementCount",{get:function(){return this._props.elementCount},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"bondCount",{get:function(){return-1===this._props.bondCount&&(this._props.bondCount=this.interUnitBonds.edgeCount+v.a.getIntraUnitBondCount(this)),this._props.bondCount},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"hasCustomProperties",{get:function(){return!!this._props.customProps&&this._props.customProps.all.length>0},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"customPropertyDescriptors",{get:function(){return this._props.customProps||(this._props.customProps=new F.CustomProperties),this._props.customProps},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"currentPropertyData",{get:function(){return this._props.propertyData||(this._props.propertyData=Object.create(null)),this._props.propertyData},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"inheritedPropertyData",{get:function(){return this.parent?this.parent.currentPropertyData:this.currentPropertyData},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"polymerResidueCount",{get:function(){return-1===this._props.polymerResidueCount&&(this._props.polymerResidueCount=function(e){for(var t=e.units,r=0,n=0,i=t.length;n<i;n++)r+=t[n].polymerElements.length;return r}(this)),this._props.polymerResidueCount},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"polymerUnitCount",{get:function(){return-1===this._props.polymerUnitCount&&(this._props.polymerUnitCount=function(e){for(var t=e.units,r=0,n=0,i=t.length;n<i;n++)t[n].polymerElements.length>0&&(r+=1);return r}(this)),this._props.polymerUnitCount},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"uniqueElementCount",{get:function(){return-1===this._props.uniqueElementCount&&(this._props.uniqueElementCount=function(e){for(var t=e.unitSymmetryGroups,r=0,n=0,i=t.length;n<i;n++)r+=t[n].elements.length;return r}(this)),this._props.uniqueElementCount},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"atomicResidueCount",{get:function(){return-1===this._props.atomicResidueCount&&(this._props.atomicResidueCount=function(e){for(var t=e.units,r=0,n=0,i=t.length;n<i;n++){var a=t[n];if(d.a.isAtomic(a))for(var o=a.elements,s=a.residueIndex,u=-1,c=-1,l=0,f=o.length;l<f;++l)(u=s[o[l]])!==c&&(r+=1,c=u)}return r}(this)),this._props.atomicResidueCount},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"isCoarseGrained",{get:function(){var e=this.elementCount,t=this.polymerResidueCount;return!(!t||!e)&&e/t<2},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"isEmpty",{get:function(){return 0===this.units.length},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"hashCode",{get:function(){return-1!==this._props.hashCode?this._props.hashCode:this.computeHash()},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"transformHash",{get:function(){return-1!==this._props.transformHash||(this._props.transformHash=Object(c.l)(this.units.map((function(e){return e.id})))),this._props.transformHash},enumerable:!1,configurable:!0}),e.prototype.computeHash=function(){for(var e=23,t=0,r=this.units.length;t<r;t++){var n=this.units[t];e=31*(e=31*e+n.id|0)+a.SortedArray.hashCode(n.elements)|0}return e=31*e+this.elementCount|0,-1===(e=Object(c.h)(e))&&(e=0),this._props.hashCode=e,e},e.prototype.elementLocations=function(){return new e.ElementLocationIterator(this)},Object.defineProperty(e.prototype,"root",{get:function(){return this._props.parent||this},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"parent",{get:function(){return this._props.parent},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"coordinateSystem",{get:function(){return this._props.coordinateSystem},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"label",{get:function(){return this._props.label},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"boundary",{get:function(){return this._props.boundary||(this._props.boundary=Q(this)),this._props.boundary},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"lookup3d",{get:function(){return this._props.lookup3d||(this._props.lookup3d=new m(this)),this._props.lookup3d},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"interUnitBonds",{get:function(){return this._props.interUnitBonds||(this._props.interUnitBonds=Object(v.b)(this)),this._props.interUnitBonds},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"unitSymmetryGroups",{get:function(){return 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this.advance(),this.current},e.prototype.setElement=function(e,t,r){this.structure=e,this.unit=t,this.index=r,this.interBondIndices=e.interUnitBonds.getEdgeIndices(r,t.id),this.interBondCount=this.interBondIndices.length,this.interBondIndex=0,this.intraBondEnd=t.bonds.offset[r+1],this.intraBondIndex=t.bonds.offset[r],this.hasNext=this.interBondIndex<this.interBondCount||this.intraBondIndex<this.intraBondEnd},e.prototype.advance=function(){if(this.intraBondIndex<this.intraBondEnd)this.current.otherUnit=this.unit,this.current.otherIndex=this.unit.bonds.b[this.intraBondIndex],this.current.type=this.unit.bonds.edgeProps.flags[this.intraBondIndex],this.current.order=this.unit.bonds.edgeProps.order[this.intraBondIndex],this.intraBondIndex+=1;else{if(!(this.interBondIndex<this.interBondCount))return void(this.hasNext=!1);var e=this.structure.interUnitBonds.edges[this.interBondIndex];this.current.otherUnit=this.structure.unitMap.get(e.unitA!==this.unit.id?e.unitA:e.unitB),this.current.otherIndex=e.indexA!==this.index?e.indexA:e.indexB,this.current.type=e.props.flag,this.current.order=e.props.order,this.interBondIndex+=1}this.hasNext=this.interBondIndex<this.interBondCount||this.intraBondIndex<this.intraBondEnd},e}();e.ElementBondIterator=u,e.getBoundingSphere=function(e,t){return s.a.fromPairProvider(e.bonds.length,(function(t,r,n){var i=e.bonds[t],a=i.aUnit,o=i.aIndex,s=i.bUnit,u=i.bIndex;a.conformation.position(a.elements[o],r),s.conformation.position(s.elements[u],n)}),t)}}(I||(I={}))},function(e,t,r){"use strict";r.d(t,"a",(function(){return O}));var n,i,a=r(0),o=r(2),s=r(8),u=r(36),c=r(9),l=r(1),d=r(24),f=r(79),p=r(57);(i=n||(n={})).create=function(e){return{entries:Object(p.b)(),capacity:Math.max(1,e)}},i.get=function(e,t){for(var r=e.entries.first;r;r=r.next)if(r.value.key===t)return e.entries.remove(r),e.entries.addLast(r.value),r.value.data},i.set=function(e,t,r){var n=void 0;if(e.entries.count>=e.capacity){var i=e.entries.first;n=i.value.data,e.entries.remove(i)}return e.entries.addLast(function(e,t){return{key:e,data:t}}(t,r)),n};var m=r(267),h=r(26),g=r(312),v=r(27),b=r(13),y=r(4),_=r(23),S=r(119),x=r(273),O=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return Object(a.__extends)(t,e),t}(s.a.CreateBehavior({name:"Volume Streaming"}));!function(e){function t(e,t,r,n,i){var a,s,c,l;return void 0===i&&(i={}),o.ParamDefinition.Group({isoValue:u.b.createIsoValueParam(null!==(a=i.isoValue)&&void 0!==a?a:r,n),color:o.ParamDefinition.Color(null!==(s=i.color)&&void 0!==s?s:t),wireframe:o.ParamDefinition.Boolean(null!==(c=i.wireframe)&&void 0!==c&&c),opacity:o.ParamDefinition.Numeric(null!==(l=i.opacity)&&void 0!==l?l:.3,{min:0,max:1,step:.01})},{label:e,isExpanded:!0})}e.RootTag="volume-streaming-info";var r={byteOffset:0,rate:1,sampleCount:[1,1,1],valuesInfo:[{mean:0,min:-1,max:1,sigma:.1},{mean:0,min:-1,max:1,sigma:.1}]};function i(n){var i=n.entryData,a=n.defaultView,s=n.structure,f=n.channelParams,p=void 0===f?{}:f,m=i||{kind:"em",header:{sampling:[r],availablePrecisions:[{precision:0,maxVoxels:0}]},emDefaultContourLevel:u.b.IsoValue.relative(0)},h=s&&s.boundary.box||Object(c.b)();return{view:o.ParamDefinition.MappedStatic(a||("em"===m.kind?"cell":"selection-box"),{off:o.ParamDefinition.Group({}),box:o.ParamDefinition.Group({bottomLeft:o.ParamDefinition.Vec3(h.min),topRight:o.ParamDefinition.Vec3(h.max)},{description:"Static box defined by cartesian coords.",isFlat:!0}),"selection-box":o.ParamDefinition.Group({radius:o.ParamDefinition.Numeric(5,{min:0,max:50,step:.5},{description:"Radius in Å within which the volume is shown."}),bottomLeft:o.ParamDefinition.Vec3(l.Vec3.create(0,0,0),{},{isHidden:!0}),topRight:o.ParamDefinition.Vec3(l.Vec3.create(0,0,0),{},{isHidden:!0})},{description:"Box around focused element.",isFlat:!0}),cell:o.ParamDefinition.Group({}),auto:o.ParamDefinition.Group({radius:o.ParamDefinition.Numeric(5,{min:0,max:50,step:.5},{description:"Radius in Å within which the volume is shown."}),selectionDetailLevel:o.ParamDefinition.Select(Math.min(6,m.header.availablePrecisions.length-1),m.header.availablePrecisions.map((function(e,t){return[t,t+1+" [ "+(0|Math.pow(e.maxVoxels,1/3))+"^3 cells ]"]})),{label:"Selection Detail",description:"Determines the maximum number of voxels. Depending on the size of the volume options are in the range from 0 (0.52M voxels) to 6 (25.17M voxels)."}),isSelection:o.ParamDefinition.Boolean(!1,{isHidden:!0}),bottomLeft:o.ParamDefinition.Vec3(h.min,{},{isHidden:!0}),topRight:o.ParamDefinition.Vec3(h.max,{},{isHidden:!0})},{description:"Box around focused element.",isFlat:!0})},{options:e.ViewTypeOptions,description:'Controls what of the volume is displayed. "Off" hides the volume alltogether. "Bounded box" shows the volume inside the given box. "Around Interaction" shows the volume around the focused element/atom. "Whole Structure" shows the volume for the whole structure.'}),detailLevel:o.ParamDefinition.Select(Math.min(3,m.header.availablePrecisions.length-1),m.header.availablePrecisions.map((function(e,t){return[t,t+1+" [ "+(0|Math.pow(e.maxVoxels,1/3))+"^3 cells ]"]})),{description:"Determines the maximum number of voxels. Depending on the size of the volume options are in the range from 0 (0.52M voxels) to 6 (25.17M voxels)."}),channels:"em"===m.kind?o.ParamDefinition.Group({em:t("EM",Object(d.Color)(6524815),m.emDefaultContourLevel||u.b.IsoValue.relative(1),m.header.sampling[0].valuesInfo[0],p.em)},{isFlat:!0}):o.ParamDefinition.Group({"2fo-fc":t("2Fo-Fc",Object(d.Color)(3367602),u.b.IsoValue.relative(1.5),m.header.sampling[0].valuesInfo[0],p["2fo-fc"]),"fo-fc(+ve)":t("Fo-Fc(+ve)",Object(d.Color)(3390259),u.b.IsoValue.relative(3),m.header.sampling[0].valuesInfo[1],p["fo-fc(+ve)"]),"fo-fc(-ve)":t("Fo-Fc(-ve)",Object(d.Color)(12268339),u.b.IsoValue.relative(-3),m.header.sampling[0].valuesInfo[1],p["fo-fc(-ve)"])},{isFlat:!0})}}e.createParams=function(e){void 0===e&&(e={});var t=e.data,r=e.defaultView,n=e.channelParams,a=new Map;t&&t.entries.forEach((function(e){return a.set(e.dataId,e)}));var s=t?t.entries.map((function(e){return[e.dataId,e.dataId]})):[],u=t?t.entries[0].dataId:"";return{entry:o.ParamDefinition.Mapped(u,s,(function(e){return o.ParamDefinition.Group(i({entryData:a.get(e),defaultView:r,structure:t&&t.structure,channelParams:n}))}))}},e.createEntryParams=i,e.ViewTypeOptions=[["off","Off"],["box","Bounded Box"],["selection-box","Around Focus"],["cell","Whole Structure"],["auto","Auto"]],e.ChannelTypeOptions=[["em","em"],["2fo-fc","2fo-fc"],["fo-fc(+ve)","fo-fc(+ve)"],["fo-fc(-ve)","fo-fc(-ve)"]];var p=function(e){function t(t,r){var i=e.call(this,t,{})||this;return i.plugin=t,i.data=r,i.cache=n.create(25),i.params={},i.lastLoci=_.EmptyLoci,i.ref="",i.channels={},i._invTransform=Object(l.Mat4)(),i.infoMap=new Map,i.data.entries.forEach((function(e){return i.infoMap.set(e.dataId,e)})),i}return Object(a.__extends)(t,e),Object.defineProperty(t.prototype,"info",{get:function(){return this.infoMap.get(this.params.entry.name)},enumerable:!1,configurable:!0}),t.prototype.queryData=function(e){return Object(a.__awaiter)(this,void 0,void 0,(function(){var t,r,i,o,s,u,c,l,d;return Object(a.__generator)(this,(function(a){switch(a.label){case 0:return t=Object(m.a)(this.data.serverUrl,this.info.kind+"/"+this.info.dataId.toLowerCase()),e?(r=e.min,i=e.max,t+="/box/"+r.map((function(e){return Math.round(1e3*e)/1e3})).join(",")+"/"+i.map((function(e){return Math.round(1e3*e)/1e3})).join(",")):t+="/cell",o=this.params.entry.params.detailLevel,"auto"===this.params.entry.params.view.name&&this.params.entry.params.view.params.isSelection&&(o=this.params.entry.params.view.params.selectionDetailLevel),t+="?detail="+o,(s=n.get(this.cache,t))?[2,s.data]:(u=S.Asset.getUrlAsset(this.plugin.managers.asset,t),[4,this.plugin.runTask(this.plugin.managers.asset.resolve(u,"binary"))]);case 1:return c=a.sent(),[4,this.parseCif(c.data)];case 2:return(l=a.sent())?((d=n.set(this.cache,t,{data:l,asset:c}))&&d.asset.dispose(),[2,l]):[2]}}))}))},t.prototype.parseCif=function(e){return Object(a.__awaiter)(this,void 0,void 0,(function(){var t,r,n,i,o,s;return Object(a.__generator)(this,(function(a){switch(a.label){case 0:return[4,this.plugin.runTask(h.a.parseBinary(e))];case 1:if((t=a.sent()).isError)return this.plugin.log.error("VolumeStreaming, parsing CIF: "+t.toString()),[2];if(t.result.blocks.length<2)return this.plugin.log.error("VolumeStreaming: Invalid data."),[2];r={},n=1,a.label=2;case 2:return n<t.result.blocks.length?(i=t.result.blocks[n],o=h.a.schema.densityServer(i),[4,this.plugin.runTask(Object(g.b)(o))]):[3,5];case 3:s=a.sent(),r[i.header]=s,a.label=4;case 4:return n++,[3,2];case 5:return[2,r]}}))}))},t.prototype.updateSelectionBoxParams=function(e){if("selection-box"===this.params.entry.params.view.name){var t=this.plugin.state.data,r=Object(a.__assign)(Object(a.__assign)({},this.params),{entry:{name:this.params.entry.name,params:Object(a.__assign)(Object(a.__assign)({},this.params.entry.params),{view:{name:"selection-box",params:{radius:this.params.entry.params.view.params.radius,bottomLeft:e.min,topRight:e.max}}})}}),n=t.build().to(this.ref).update(r);v.PluginCommands.State.Update(this.plugin,{state:t,tree:n,options:{doNotUpdateCurrent:!0}})}},t.prototype.updateAutoParams=function(e,t){if("auto"===this.params.entry.params.view.name){var r=this.plugin.state.data,n=Object(a.__assign)(Object(a.__assign)({},this.params),{entry:{name:this.params.entry.name,params:Object(a.__assign)(Object(a.__assign)({},this.params.entry.params),{view:{name:"auto",params:{radius:this.params.entry.params.view.params.radius,selectionDetailLevel:this.params.entry.params.view.params.selectionDetailLevel,isSelection:t,bottomLeft:(null==e?void 0:e.min)||l.Vec3.zero(),topRight:(null==e?void 0:e.max)||l.Vec3.zero()}}})}}),i=r.build().to(this.ref).update(n);v.PluginCommands.State.Update(this.plugin,{state:r,tree:i,options:{doNotUpdateCurrent:!0}})}},t.prototype.getStructureRoot=function(){return this.plugin.state.data.select(b.StateSelection.Generators.byRef(this.ref).rootOfType(s.a.Molecule.Structure))[0]},t.prototype.register=function(e){var t=this;this.ref=e,this.subscribeObservable(this.plugin.state.events.object.removed,(function(e){s.a.Molecule.Structure.is(e.obj)&&y.StructureElement.Loci.is(t.lastLoci)&&t.lastLoci.structure===e.obj.data&&(t.lastLoci=_.EmptyLoci)})),this.subscribeObservable(this.plugin.state.events.object.updated,(function(e){s.a.Molecule.Structure.is(e.oldObj)&&y.StructureElement.Loci.is(t.lastLoci)&&t.lastLoci.structure===e.oldObj.data&&(t.lastLoci=_.EmptyLoci)})),this.subscribeObservable(this.plugin.managers.structure.focus.behaviors.current,(function(e){if(t.plugin.state.data.tree.children.has(t.ref)){var r=e?e.loci:_.EmptyLoci;switch(t.params.entry.params.view.name){case"auto":t.updateAuto(r);break;case"selection-box":t.updateSelectionBox(r);break;default:t.lastLoci=r}}}))},t.prototype.unregister=function(){for(var e=this.cache.entries.first;e;)e.value.data.asset.dispose(),e=e.next},t.prototype.getBoxFromLoci=function(e){var t,r,n;if(_.Loci.isEmpty(e))return Object(c.b)();var i=this.plugin.helpers.substructureParent.get(e.structure,!0);if(!i)return Object(c.b)();var a=this.getStructureRoot();if(!a||(null===(t=a.obj)||void 0===t?void 0:t.data)!==(null===(r=i.obj)||void 0===r?void 0:r.data))return Object(c.b)();var o=x.a.get(null===(n=a.obj)||void 0===n?void 0:n.data.models[0]);o&&l.Mat4.invert(this._invTransform,o);var s=y.StructureElement.Loci.extendToWholeResidues(e),u=y.StructureElement.Loci.getBoundary(s,o&&!Number.isNaN(this._invTransform[0])?this._invTransform:void 0).box;return 1===y.StructureElement.Loci.size(s)&&c.b.expand(u,u,l.Vec3.create(1,1,1)),u},t.prototype.updateAuto=function(e){if(this.lastLoci=e,Object(_.isEmptyLoci)(e))this.updateAutoParams("x-ray"===this.info.kind?this.data.structure.boundary.box:void 0,!1);else{var t=this.getBoxFromLoci(e);this.updateAutoParams(t,!0)}},t.prototype.updateSelectionBox=function(e){if(_.Loci.areEqual(this.lastLoci,e))return this.lastLoci=_.EmptyLoci,void this.updateSelectionBoxParams(Object(c.b)());if(this.lastLoci=e,Object(_.isEmptyLoci)(e))this.updateSelectionBoxParams(Object(c.b)());else{var t=this.getBoxFromLoci(e);this.updateSelectionBoxParams(t)}},t.prototype.update=function(e){return Object(a.__awaiter)(this,void 0,void 0,(function(){var t,r,n,i,o,s,d;return Object(a.__generator)(this,(function(a){switch(a.label){case 0:switch(t="selection-box"===e.entry.params.view.name&&this.params&&this.params.entry&&this.params.entry.params&&this.params.entry.params.view&&"selection-box"!==this.params.entry.params.view.name,this.params=e,r=void 0,n=!1,e.entry.params.view.name){case"off":n=!0;break;case"box":r=c.b.create(e.entry.params.view.params.bottomLeft,e.entry.params.view.params.topRight),n=c.b.volume(r)<1e-4;break;case"selection-box":r=t?this.getBoxFromLoci(this.lastLoci)||Object(c.b)():c.b.create(l.Vec3.clone(e.entry.params.view.params.bottomLeft),l.Vec3.clone(e.entry.params.view.params.topRight)),i=e.entry.params.view.params.radius,n=c.b.volume(r)<1e-4,c.b.expand(r,r,l.Vec3.create(i,i,i));break;case"cell":r="x-ray"===this.info.kind?this.data.structure.boundary.box:void 0;break;case"auto":(r=e.entry.params.view.params.isSelection||"x-ray"===this.info.kind?c.b.create(l.Vec3.clone(e.entry.params.view.params.bottomLeft),l.Vec3.clone(e.entry.params.view.params.topRight)):void 0)&&(n=c.b.volume(r)<1e-4,e.entry.params.view.params.isSelection&&(i=e.entry.params.view.params.radius,c.b.expand(r,r,l.Vec3.create(i,i,i))))}return n?(s={},[3,3]):[3,1];case 1:return[4,this.queryData(r)];case 2:s=a.sent(),a.label=3;case 3:return(o=s)?(d=e.entry.params.channels,"x-ray"===this.info.kind?(this.channels["2fo-fc"]=this.createChannel(o["2FO-FC"]||u.b.One,d["2fo-fc"],this.info.header.sampling[0].valuesInfo[0]),this.channels["fo-fc(+ve)"]=this.createChannel(o["FO-FC"]||u.b.One,d["fo-fc(+ve)"],this.info.header.sampling[0].valuesInfo[1]),this.channels["fo-fc(-ve)"]=this.createChannel(o["FO-FC"]||u.b.One,d["fo-fc(-ve)"],this.info.header.sampling[0].valuesInfo[1])):this.channels.em=this.createChannel(o.EM||u.b.One,d.em,this.info.header.sampling[0].valuesInfo[0]),[2,!0]):[2,!1]}}))}))},t.prototype.createChannel=function(e,t,r){var n=t;return{data:e,color:n.color,wireframe:n.wireframe,opacity:n.opacity,isoValue:"relative"===n.isoValue.kind?n.isoValue:u.b.IsoValue.toRelative(n.isoValue,r)}},t.prototype.getDescription=function(){return"selection-box"===this.params.entry.params.view.name?"Selection":"box"===this.params.entry.params.view.name?"Static Box":"cell"===this.params.entry.params.view.name?"Cell":""},t}(f.a.WithSubscribers);e.Behavior=p}(O||(O={}))},function(e,t,r){"use strict";r.d(t,"a",(function(){return s}));var n=r(46),i=r(244),a=r(44),o=r(70);function s(){return s.zero()}!function(e){function t(){var e=[.1,0,0];return e[0]=0,e}function r(e,t){var r=t[0],n=t[1],i=t[2],o=Math.sqrt(n*n+i*i),s=(Object(a.f)(Math.atan2(i,n))+360)%360;return 0===Math.round(1e4*o)&&(s=Number.NaN),e[0]=s,e[1]=o,e[2]=r,e}function s(e,t,r){return e[0]=t[0]-l*r,e[1]=t[1],e[2]=t[2],e}e.zero=t,e.create=function(e,r,n){var i=t();return i[0]=e,i[1]=r,i[2]=n,i},e.fromColor=function(e,t){var r=n.Color.toRgb(t),i=function(e,t,r){e=b(e),t=b(t),r=b(r);var n=y((.4124564*e+.3575761*t+.1804375*r)/d),i=y((.2126729*e+.7151522*t+.072175*r)/f),a=y((.0193339*e+.119192*t+.9503041*r)/p);return[n,i,a]}(r[0],r[1],r[2]),a=i[0],o=i[1],s=i[2],u=116*o-16;return e[0]=u<0?0:u,e[1]=500*(a-o),e[2]=200*(o-s),e},e.fromHcl=function(e,t){return i.a.toLab(e,t)},e.toColor=function(e){var t=(e[0]+16)/116,r=isNaN(e[1])?t:t+e[1]/500,i=isNaN(e[2])?t:t-e[2]/200;t=f*v(t);var a=g(3.2404542*(r=d*v(r))-1.5371385*t-.4985314*(i=p*v(i))),s=g(-.969266*r+1.8760108*t+.041556*i),u=g(.0556434*r-.2040259*t+1.0572252*i);return n.Color.fromRgb(Math.round(Object(o.a)(a,0,255)),Math.round(Object(o.a)(s,0,255)),Math.round(Object(o.a)(u,0,255)))},e.toHcl=r,e.copy=function(e,t){return e[0]=t[0],e[1]=t[1],e[2]=t[2],e},e.darken=s,e.lighten=function(e,t,r){return s(e,t,-r)};var u=[0,0,0];function c(e,t,n){return r(u,t),i.a.toLab(e,i.a.saturate(u,u,n))}e.saturate=c,e.desaturate=function(e,t,r){return c(e,t,-r)};var l=18,d=.95047,f=1,p=1.08883,m=.137931034,h=.12841855;function g(e){return 255*(e<=.00304?12.92*e:1.055*Math.pow(e,1/2.4)-.055)}function v(e){return e>.206896552?e*e*e:h*(e-m)}function b(e){return(e/=255)<=.04045?e/12.92:Math.pow((e+.055)/1.055,2.4)}function y(e){return e>.008856452?Math.pow(e,1/3):e/h+m}}(s||(s={}))},function(e,t,r){"use strict";r.d(t,"a",(function(){return n}));var n,i=r(0),a=r(5),o=r(1),s=r(122),u=r(115),c=r(124),l=r(132),d=r(53),f=r(2),p=r(52),m=r(9),h=r(30),g=r(129),v=r(130),b=r(12),y=r(136);!function(e){function t(e,t,r,i,o,u,c,l,d){return d?function(e,t,r,n,i,o,s,u,c){u>c.cylinderCount&&(a.e.update(c.mappingBuffer,e),a.e.update(c.indexBuffer,t));return c.cylinderCount=u,a.e.update(c.groupBuffer,r),a.e.update(c.startBuffer,n),a.e.update(c.endBuffer,i),a.e.update(c.scaleBuffer,o),a.e.update(c.capBuffer,s),c}(e,t,r,i,o,u,c,l,d):function(e,t,r,i,o,u,c,l){var 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c.d.Location.distance(this.a,this.b)},enumerable:!1,configurable:!0}),e}();(s||(s={})).run=function(e,t,r){return e(new f(t,r))};var m=r(0),h=r(57),g=r(6),v=r(118),b=r(159),y=function(){function e(e){this.source=e,this.set=Object(h.a)(c.c.hashCode,c.c.areUnitIdsAndIndicesEqual),this.structures=[],this.allSingletons=!0}return e.prototype.add=function(e){e.elementCount&&(1!==e.elementCount&&(this.allSingletons=!1),this.set.add(e)&&(this.structures[this.structures.length]=e))},e.prototype.getSelection=function(){return this.allSingletons?u.a.Singletons(this.source,Object(b.e)(this.source,this.structures)):u.a.Sequence(this.source,this.structures)},e}(),_=function(){function e(e){this.source=e,this.builders=[],this.builderMap=new Map}return e.prototype.add=function(e,t,r){var n=this.builderMap.get(e);n||(n=this.source.subsetBuilder(!0),this.builders[this.builders.length]=n,this.builderMap.set(e,n)),n.addToUnit(t,r)},e.prototype.allSingletons=function(){for(var e=0,t=this.builders.length;e<t;e++)if(this.builders[e].elementCount>1)return!1;return!0},e.prototype.singletonSelection=function(){for(var e=this.source.subsetBuilder(!0),t=c.d.Location.create(this.source),r=0,n=this.builders.length;r<n;r++)this.builders[r].setSingletonLocation(t),e.addToUnit(t.unit.id,t.element);return u.a.Singletons(this.source,e.getStructure())},e.prototype.fullSelection=function(){for(var e=new Array(this.builders.length),t=0,r=this.builders.length;t<r;t++)e[t]=this.builders[t].getStructure();return u.a.Sequence(this.source,e)},e.prototype.getSelection=function(){return 0===this.builders.length?u.a.Empty(this.source):this.allSingletons()?this.singletonSelection():this.fullSelection()},e}(),S=function(e){return u.a.Sequence(e.inputStructure,[])},x=function(e){return u.a.Singletons(e.inputStructure,e.inputStructure)};function O(e){return P(Object(m.__assign)(Object(m.__assign)({},e),{groupBy:function(e){return c.e.residue.key(e.element)}}))}function w(e){return P(Object(m.__assign)(Object(m.__assign)({},e),{groupBy:function(e){return c.e.chain.key(e.element)}}))}function C(e){return!0}function j(e){return 0}function P(e){if(!(e&&(e.atomTest||e.residueTest||e.chainTest||e.entityTest||e.unitTest||e.groupBy)))return x;if(e.atomTest&&!e.residueTest&&!e.chainTest&&!e.entityTest&&!e.unitTest&&!e.groupBy)return t=e.atomTest,function(e){var r=e.inputStructure,n=r.units,i=e.pushCurrentElement(),a=r.subsetBuilder(!0);i.structure=r;for(var o=0,s=n;o<s.length;o++){var c=s[o];i.unit=c;var l=c.elements;a.beginUnit(c.id);for(var d=0,f=l.length;d<f;d++)i.element=l[d],t(e)&&a.addElement(i.element);a.commitUnit(),e.throwIfTimedOut()}return e.popCurrentElement(),u.a.Singletons(r,a.getStructure())};var t,r={unitTest:e.unitTest||C,entityTest:e.entityTest||C,chainTest:e.chainTest||C,residueTest:e.residueTest||C,atomTest:e.atomTest||C,groupBy:e.groupBy||j};return e.groupBy?function(e){var t=e.unitTest,r=e.entityTest,n=e.chainTest,i=e.residueTest,a=e.atomTest,o=e.groupBy;return function(e){var s=e.inputStructure,u=s.units,c=e.pushCurrentElement(),l=new _(s);c.structure=s;for(var d=0,f=u;d<f.length;d++){var p=f[d];if(c.unit=p,t(e)){var m=p.elements,h=p.model;if(0===p.kind)for(var v=g.Segmentation.transientSegments(h.atomicHierarchy.chainAtomSegments,m),b=g.Segmentation.transientSegments(h.atomicHierarchy.residueAtomSegments,m);v.hasNext;){var y=v.move();if(c.element=m[y.start],r(e)&&n(e))for(b.setSegment(y);b.hasNext;){var S=b.move();if(c.element=m[S.start],i(e))for(var x=S.start,O=S.end;x<O;x++)c.element=m[x],a(e)&&l.add(o(e),p.id,c.element)}}else{var w=h.coarseHierarchy.spheres.chainElementSegments;for(v=g.Segmentation.transientSegments(w,m);v.hasNext;){y=v.move();if(c.element=m[y.start],r(e)&&n(e))for(x=y.start,O=y.end;x<O;x++)c.element=m[x],i(e)&&l.add(o(e),p.id,c.element)}}e.throwIfTimedOut()}}return e.popCurrentElement(),l.getSelection()}}(r):function(e){var t=e.unitTest,r=e.entityTest,n=e.chainTest,i=e.residueTest,a=e.atomTest;return function(e){var o=e.inputStructure,s=o.units,c=e.pushCurrentElement(),l=o.subsetBuilder(!0),d=i===C&&a===C,f=a===C;c.structure=o;for(var p=0,m=s;p<m.length;p++){var h=m[p];if(c.unit=h,t(e)){var v=h.elements,b=h.model;if(l.beginUnit(h.id),0===h.kind)for(var y=g.Segmentation.transientSegments(h.model.atomicHierarchy.chainAtomSegments,v),_=g.Segmentation.transientSegments(h.model.atomicHierarchy.residueAtomSegments,v);y.hasNext;){var S=y.move();if(c.element=v[S.start],r(e)&&n(e))if(d)l.addElementRange(v,S.start,S.end);else for(_.setSegment(S);_.hasNext;){var x=_.move();if(c.element=v[x.start],i(e))if(f)l.addElementRange(v,x.start,x.end);else for(var O=x.start,w=x.end;O<w;O++)c.element=v[O],a(e)&&l.addElement(c.element)}}else{var j=b.coarseHierarchy.spheres.chainElementSegments;for(y=g.Segmentation.transientSegments(j,v);y.hasNext;){S=y.move();if(c.element=v[S.start],r(e)&&n(e))if(d)l.addElementRange(v,S.start,S.end);else for(O=S.start,w=S.end;O<w;O++)c.element=v[O],i(e)&&l.addElement(c.element)}}l.commitUnit(),e.throwIfTimedOut()}}return e.popCurrentElement(),u.a.Singletons(o,l.getStructure())}}(r)}function E(e,t,r){for(var n=new Int32Array(t.length),i=0,a=t.length;i<a;i++)n[i]=e.elements[t[i]];return v.a.create([e.getChild(g.SortedArray.ofSortedArray(n))],{parent:r})}function A(e,t){return function(r){var n=r.inputStructure.units,i=u.a.LinearBuilder(r.inputStructure);if(e&&0!==e.length){for(var a=h.c.create(),o=0;o<e.length;o++)h.c.add(a,e[o],e[o]);for(var s=0,l=n;s<l.length;s++){_=l[s];if(c.g.isAtomic(_))for(var d=_.rings,f=0,p=a.array;f<p.length;f++){var m=p[f];if(d.byFingerprint.has(m))for(var g=0,v=d.byFingerprint.get(m);g<v.length;g++){O=v[g];t&&!d.aromaticRings.includes(O)||i.add(E(_,d.all[O],r.inputStructure))}}}}else for(var b=0,y=n;b<y.length;b++){var _=y[b];if(c.g.isAtomic(_))if(t)for(var S=0,x=_.rings.aromaticRings;S<x.length;S++){var O=x[S];i.add(E(_,_.rings.all[O],r.inputStructure))}else for(var w=0,C=_.rings.all;w<C.length;w++){var O=C[w];i.add(E(_,O,r.inputStructure))}}return i.getSelection()}}function D(e,t,r){return void 0===r&&(r=!1),function(n){var i=e(n);if(0===u.a.structureCount(i))return i;var a=r?Object(b.d)(n.inputStructure,u.a.unionStructure(i)):u.a.unionStructure(i);if(0===a.elementCount)return u.a.Empty(n.inputStructure);n.throwIfTimedOut(),n.pushInputStructure(a);var o=t(n);return n.popInputStructure(),u.a.withInputStructure(o,n.inputStructure)}}function T(e){return function(t){var r=t.inputStructure,n=r.interUnitBonds,i=u.a.UniqueBuilder(t.inputStructure);t.pushCurrentBond();var a=t.atomicBond;a.setTestFn(e),a.setStructure(r);for(var o=0,s=r.units;o<s.length;o++){var c=s[o];if(0===c.kind){var l=c.bonds,d=l.offset,f=l.b,p=l.edgeProps,m=p.flags,h=p.order;a.a.unit=c,a.b.unit=c;for(var g=0,v=c.elements.length;g<v;g++){a.aIndex=g,a.a.element=c.elements[g];for(var b=d[g],y=d[g+1];b<y;b++){if(a.bIndex=f[b],a.b.element=c.elements[f[b]],a.type=m[b],a.order=h[b],a.test(t,!1))(x=r.subsetBuilder(!1)).beginUnit(c.id),x.addElement(a.a.element),x.addElement(a.b.element),x.commitUnit(),i.add(x.getStructure())}}}}for(var _=0,S=n.edges;_<S.length;_++){var x,O=S[_];if(a.a.unit=r.unitMap.get(O.unitA),a.a.element=a.a.unit.elements[O.indexA],a.aIndex=O.indexA,a.b.unit=r.unitMap.get(O.unitA),a.b.element=a.b.unit.elements[O.indexB],a.bIndex=O.indexB,a.order=O.props.order,a.type=O.props.flag,a.test(t,!1))(x=r.subsetBuilder(!1)).addToUnit(a.a.unit.id,a.a.element),x.addToUnit(a.b.unit.id,a.b.element),i.add(x.getStructure())}return t.popCurrentBond(),i.getSelection()}}var I=r(12),M=r(251),k=function(){function 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e=[];Object(I.q)(this.ids);for(var t=M.a.UnitEquivalenceBuilder(),r=0,n=this.ids.length;r<n;r++){var i=this.ids[r],a=this.parent.unitMap.get(i),o=this.unitMap.get(i).array,s=o.length;if(o.length!==a.elements.length){s>1&&Object(I.q)(o);var u=a.getChild(g.SortedArray.ofSortedArray(o)),c=t.add(u.id,u);u!==c&&(u=c.applyOperator(u.id,u.conformation.operator,!0)),e[e.length]=u}else e[e.length]=a,t.add(a.id,a)}return v.a.create(e,{parent:this.parent})},Object.defineProperty(e.prototype,"isEmpty",{get:function(){return 0===this.elementCount},enumerable:!1,configurable:!0}),e}();function B(e,t,r){for(var n=t.subsetBuilder(!0),i=0,a=r.units;i<a.length;i++){var o=a[i];if(0===o.kind){var s=o.model.atomicHierarchy.residueAtomSegments,u=t.unitMap.get(o.id).elements,c=o.elements;n.beginUnit(o.id);for(var l=g.Segmentation.transientSegments(s,c);l.hasNext;)for(var d=l.move().index,f=s.offsets[d],p=s.offsets[d+1];f<p;f++)g.SortedArray.has(u,f)&&n.addElement(f);n.commitUnit(),e.throwIfTimedOut()}else 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r=this.renderable.values,n=t.edgeThresholdMin,i=t.edgeThresholdMax,a=t.iterations,o=t.subpixelQuality,u=!1;r.tColor.ref.value!==e&&(s.e.update(this.renderable.values.tColor,e),u=!0),r.dEdgeThresholdMin.ref.value!==n&&(u=!0),s.e.updateIfChanged(r.dEdgeThresholdMin,n),r.dEdgeThresholdMax.ref.value!==i&&(u=!0),s.e.updateIfChanged(r.dEdgeThresholdMax,i),r.dIterations.ref.value!==a&&(u=!0),s.e.updateIfChanged(r.dIterations,a),r.dSubpixelQuality.ref.value!==o&&(u=!0),s.e.updateIfChanged(r.dSubpixelQuality,o),u&&this.renderable.update()},e.prototype.render=function(e,t){t?t.bind():this.webgl.unbindFramebuffer(),this.updateState(e),this.renderable.render()},e}(),g=Object(n.__assign)(Object(n.__assign)({},i.b),{tColor:Object(a.i)("texture","rgba","ubyte","linear"),uTexSizeInv:Object(a.j)("v2"),dEdgeThresholdMin:Object(a.c)("number"),dEdgeThresholdMax:Object(a.c)("number"),dIterations:Object(a.c)("number"),dSubpixelQuality:Object(a.c)("number")}),v=Object(o.g)("fxaa",f.a,"\nprecision highp float;\nprecision highp int;\nprecision highp sampler2D;\n\nuniform sampler2D tColor;\nuniform vec2 uTexSizeInv;\n\n// adapted from https://github.com/kosua20/Rendu\n// MIT License Copyright (c) 2017 Simon Rodriguez\n\n#define QUALITY(q) ((q) < 5 ? 1.0 : ((q) > 5 ? ((q) < 10 ? 2.0 : ((q) < 11 ? 4.0 : 8.0)) : 1.5))\n\nfloat rgb2luma(vec3 rgb){\n    return sqrt(dot(rgb, vec3(0.299, 0.587, 0.114)));\n}\n\nfloat sampleLuma(vec2 uv) {\n    return rgb2luma(texture2D(tColor, uv).rgb);\n}\n\nfloat sampleLuma(vec2 uv, float uOffset, float vOffset) {\n    uv += uTexSizeInv * vec2(uOffset, vOffset);\n    return sampleLuma(uv);\n}\n\nvoid main(void) {\n    vec2 coords = gl_FragCoord.xy * uTexSizeInv;\n    vec2 inverseScreenSize = uTexSizeInv;\n\n    vec4 colorCenter = texture2D(tColor, coords);\n\n    // Luma at the current fragment\n    float lumaCenter = rgb2luma(colorCenter.rgb);\n\n    // Luma at the four direct neighbours of the current fragment.\n    float lumaDown = sampleLuma(coords, 0.0, -1.0);\n    float lumaUp = sampleLuma(coords, 0.0, 1.0);\n    float lumaLeft = sampleLuma(coords, -1.0, 0.0);\n    float lumaRight = sampleLuma(coords, 1.0, 0.0);\n\n    // Find the maximum and minimum luma around the current fragment.\n    float lumaMin = min(lumaCenter, min(min(lumaDown, lumaUp), min(lumaLeft, lumaRight)));\n    float lumaMax = max(lumaCenter, max(max(lumaDown, lumaUp), max(lumaLeft, lumaRight)));\n\n    // Compute the delta.\n    float lumaRange = lumaMax - lumaMin;\n\n    // If the luma variation is lower that a threshold (or if we are in a really dark area),\n    // we are not on an edge, don't perform any AA.\n    if (lumaRange < max(dEdgeThresholdMin, lumaMax * dEdgeThresholdMax)) {\n        gl_FragColor = colorCenter;\n        return;\n    }\n\n    // Query the 4 remaining corners lumas.\n    float lumaDownLeft = sampleLuma(coords, -1.0, -1.0);\n    float lumaUpRight = sampleLuma(coords, 1.0, 1.0);\n    float lumaUpLeft = sampleLuma(coords, -1.0, 1.0);\n    float lumaDownRight = sampleLuma(coords, 1.0, -1.0);\n\n    // Combine the four edges lumas (using intermediary variables for future computations\n    // with the same values).\n    float lumaDownUp = lumaDown + lumaUp;\n    float lumaLeftRight = lumaLeft + lumaRight;\n\n    // Same for corners\n    float lumaLeftCorners = lumaDownLeft + lumaUpLeft;\n    float lumaDownCorners = lumaDownLeft + lumaDownRight;\n    float lumaRightCorners = lumaDownRight + lumaUpRight;\n    float lumaUpCorners = lumaUpRight + lumaUpLeft;\n\n    // Compute an estimation of the gradient along the horizontal and vertical axis.\n    float edgeHorizontal = abs(-2.0 * lumaLeft + lumaLeftCorners) + abs(-2.0 * lumaCenter + lumaDownUp) * 2.0 + abs(-2.0 * lumaRight + lumaRightCorners);\n    float edgeVertical = abs(-2.0 * lumaUp + lumaUpCorners) + abs(-2.0 * lumaCenter + lumaLeftRight) * 2.0 + abs(-2.0 * lumaDown + lumaDownCorners);\n\n    // Is the local edge horizontal or vertical ?\n    bool isHorizontal = (edgeHorizontal >= edgeVertical);\n\n    // Choose the step size (one pixel) accordingly.\n    float stepLength = isHorizontal ? inverseScreenSize.y : inverseScreenSize.x;\n\n    // Select the two neighboring texels lumas in the opposite direction to the local edge.\n    float luma1 = isHorizontal ? lumaDown : lumaLeft;\n    float luma2 = isHorizontal ? lumaUp : lumaRight;\n    // Compute gradients in this direction.\n    float gradient1 = luma1 - lumaCenter;\n    float gradient2 = luma2 - lumaCenter;\n\n    // Which direction is the steepest ?\n    bool is1Steepest = abs(gradient1) >= abs(gradient2);\n\n    // Gradient in the corresponding direction, normalized.\n    float gradientScaled = 0.25 * max(abs(gradient1), abs(gradient2));\n\n    // Average luma in the correct direction.\n    float lumaLocalAverage = 0.0;\n    if(is1Steepest){\n        // Switch the direction\n        stepLength = -stepLength;\n        lumaLocalAverage = 0.5 * (luma1 + lumaCenter);\n    } else {\n        lumaLocalAverage = 0.5 * (luma2 + lumaCenter);\n    }\n\n    // Shift UV in the correct direction by half a pixel.\n    vec2 currentUv = coords;\n    if(isHorizontal){\n        currentUv.y += stepLength * 0.5;\n    } else {\n        currentUv.x += stepLength * 0.5;\n    }\n\n    // Compute offset (for each iteration step) in the right direction.\n    vec2 offset = isHorizontal ? vec2(inverseScreenSize.x, 0.0) : vec2(0.0, inverseScreenSize.y);\n    // Compute UVs to explore on each side of the edge, orthogonally.\n    // The QUALITY allows us to step faster.\n    vec2 uv1 = currentUv - offset * QUALITY(0);\n    vec2 uv2 = currentUv + offset * QUALITY(0);\n\n    // Read the lumas at both current extremities of the exploration segment,\n    // and compute the delta wrt to the local average luma.\n    float lumaEnd1 = sampleLuma(uv1);\n    float lumaEnd2 = sampleLuma(uv2);\n    lumaEnd1 -= lumaLocalAverage;\n    lumaEnd2 -= lumaLocalAverage;\n\n    // If the luma deltas at the current extremities is larger than the local gradient,\n    // we have reached the side of the edge.\n    bool reached1 = abs(lumaEnd1) >= gradientScaled;\n    bool reached2 = abs(lumaEnd2) >= gradientScaled;\n    bool reachedBoth = reached1 && reached2;\n\n    // If the side is not reached, we continue to explore in this direction.\n    if(!reached1){\n        uv1 -= offset * QUALITY(1);\n    }\n    if(!reached2){\n        uv2 += offset * QUALITY(1);\n    }\n\n    // If both sides have not been reached, continue to explore.\n    if(!reachedBoth){\n        for(int i = 2; i < dIterations; i++){\n            // If needed, read luma in 1st direction, compute delta.\n            if(!reached1){\n                lumaEnd1 = sampleLuma(uv1);\n                lumaEnd1 = lumaEnd1 - lumaLocalAverage;\n            }\n            // If needed, read luma in opposite direction, compute delta.\n            if(!reached2){\n                lumaEnd2 = sampleLuma(uv2);\n                lumaEnd2 = lumaEnd2 - lumaLocalAverage;\n            }\n            // If the luma deltas at the current extremities is larger than the local gradient,\n            // we have reached the side of the edge.\n            reached1 = abs(lumaEnd1) >= gradientScaled;\n            reached2 = abs(lumaEnd2) >= gradientScaled;\n            reachedBoth = reached1 && reached2;\n\n            // If the side is not reached, we continue to explore in this direction,\n            // with a variable quality.\n            if(!reached1){\n                uv1 -= offset * QUALITY(i);\n            }\n            if(!reached2){\n                uv2 += offset * QUALITY(i);\n            }\n\n            // If both sides have been reached, stop the exploration.\n            if(reachedBoth){\n                break;\n            }\n        }\n    }\n\n    // Compute the distances to each side edge of the edge (!).\n    float distance1 = isHorizontal ? (coords.x - uv1.x) : (coords.y - uv1.y);\n    float distance2 = isHorizontal ? (uv2.x - coords.x) : (uv2.y - coords.y);\n\n    // In which direction is the side of the edge closer ?\n    bool isDirection1 = distance1 < distance2;\n    float distanceFinal = min(distance1, distance2);\n\n    // Thickness of the edge.\n    float edgeThickness = (distance1 + distance2);\n\n    // Is the luma at center smaller than the local average ?\n    bool isLumaCenterSmaller = lumaCenter < lumaLocalAverage;\n\n    // If the luma at center is smaller than at its neighbour,\n    // the delta luma at each end should be positive (same variation).\n    bool correctVariation1 = (lumaEnd1 < 0.0) != isLumaCenterSmaller;\n    bool correctVariation2 = (lumaEnd2 < 0.0) != isLumaCenterSmaller;\n\n    // Only keep the result in the direction of the closer side of the edge.\n    bool correctVariation = isDirection1 ? correctVariation1 : correctVariation2;\n\n    // UV offset: read in the direction of the closest side of the edge.\n    float pixelOffset = - distanceFinal / edgeThickness + 0.5;\n\n    // If the luma variation is incorrect, do not offset.\n    float finalOffset = correctVariation ? pixelOffset : 0.0;\n\n    // Sub-pixel shifting\n    // Full weighted average of the luma over the 3x3 neighborhood.\n    float lumaAverage = (1.0 / 12.0) * (2.0 * (lumaDownUp + lumaLeftRight) + lumaLeftCorners + lumaRightCorners);\n    // Ratio of the delta between the global average and the center luma,\n    // over the luma range in the 3x3 neighborhood.\n    float subPixelOffset1 = clamp(abs(lumaAverage - lumaCenter) / lumaRange, 0.0, 1.0);\n    float subPixelOffset2 = (-2.0 * subPixelOffset1 + 3.0) * subPixelOffset1 * subPixelOffset1;\n    // Compute a sub-pixel offset based on this delta.\n    float subPixelOffsetFinal = subPixelOffset2 * subPixelOffset2 * float(dSubpixelQuality);\n\n    // Pick the biggest of the two offsets.\n    finalOffset = max(finalOffset, subPixelOffsetFinal);\n\n    // Compute the final UV coordinates.\n    vec2 finalUv = coords;\n    if(isHorizontal){\n        finalUv.y += finalOffset * stepLength;\n    } else {\n        finalUv.x += finalOffset * stepLength;\n    }\n\n    // Read the color at the new UV coordinates, and use it.\n    gl_FragColor = texture2D(tColor, finalUv);\n}\n");var b=r(204),y=r(105),_=r(48),S={edgeThreshold:d.ParamDefinition.Numeric(.1,{min:.05,max:.15,step:.01}),maxSearchSteps:d.ParamDefinition.Numeric(16,{min:0,max:32,step:1})},x=function(){function e(e,t){if(this.webgl=e,this._supported=!1,void 0!==typeof HTMLImageElement){var r=t.getWidth(),a=t.getHeight();this.edgesTarget=e.createRenderTarget(r,a,!1,"uint8","linear"),this.weightsTarget=e.createRenderTarget(r,a,!1,"uint8","linear"),this.edgesRenderable=function(e,t){var r=t.getWidth(),a=t.getHeight(),o=Object(n.__assign)(Object(n.__assign)({},i.c),{tColor:s.e.create(t),uTexSizeInv:s.e.create(l.Vec2.create(1/r,1/a)),uViewport:s.e.create(Object(l.Vec4)()),dEdgeThreshold:s.e.create(.1)}),d=Object(n.__assign)({},O),f=Object(u.a)(e,"triangles",w,d,o);return Object(c.a)(f,o)}(e,t),this.weightsRenderable=function(e,t){var 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/x0/4qxoPHjx+PXY9pqX9bgMvh/Nz9kpP4pOe1/fYf3axUiMdHLlPpZCNjgtNFAhcHEDxTumNONhHrBduW+vOyY++70WWnPXj98eA4kOt/mj/5E05l9+O4o8ePx67HFqyC+qSSnyselqjZGaVK2TadbFLPWAQ4NBhHqDCCV7OTpo34AlSSylPtIdd2AJZlyzYQrDJ5lcWGNceD80CunPLGGzsfD+7wRb95NevJI5docQ3tgCyr5bGnyaPRlmwNsFELViOOx9loebGNq2moDOKpHLVP5al2cymWHbkfzGXL7kfRl44H9wZy33tvt+PB/Xnf93e+nh5ZlU18wCiRUa9m7kib9LYuOk+hudQNbxwm0AQqbfloimaB2lM5fChex+ylMwuTbfmXQtmWlenZljbdXTLuOxjI/fDDHY4Hjx8/Hrse0zXfPFxbUN1kKqSCCSk50m0Ajtx3ub9XHBKHXESb8iO6E+qGytF4nO0OG3SXzbJlhxBnKtKyl0NwybjvYCD30aMdjgePHz8eu56SVTBbgxJMliQ3Oauwg0QHxXE2Ez/EIReLdQj42Gzb4CLS0YJD9xUx7bsi0vJi5mUbW1QzL0h0PFk17rtiIPfJk52MB48fPx67npJJwyrBa2RCCQRTbGZSPCxTPOiND4G2pYyOQ4h4jINIJh5wFU1NFZt+IsZ59LSnDqBjZ2awbOku+yInunLcd8VA7rNnOxkPHj9+PGY9B0MWJJNozOJmlglvDMXDEozdhQWbgs/U6oBanGzLrdSNNnZFjOkmbi5bNt1lX7JLLhn3vXAg9/h4y/Hg8ePHI9dzQMEkWCgdRfYykYKnkP7D4rIujsujaKPBsB54vE2TS00ccvFY/Tth7JXeq1hz+qgVy04sAJawTsvOknHfCwdyT062HA8eP348Zj0vdoXF4pilKa2BROed+9fyw9rWRXeTFXESMOanvDZfJuJaSXouQdMdDJZtekZcLLvEeK04d8m474UDuaenW44Hjx8/Xns9YYqZpszGWB3AN/4VHw+k7WSFtJ3Qicuqb/NlVmgXWsxh570xg2UwxUw3WfO6B5nOuO8aA7lnZxuPB48fPx6znm1i4bsfcbaptF3zNT78eFPtwi1OaCNOqp1x3zUGcs/PN++AGD1+fMXrSVm2baTtPhPahbPhA71wIHd2bXzRa69nG+3CraTtPivahV/55tXWg8fyRY/9AdsY8VbSdp8V7cKrrgdfM//z6ILQFtJ2nxHtwmuoB4/kf74+gLeRtvvMaBdeSz34+vifx0YG20jbfTa0C6+tHrwe//NmOG0L8EbSdp8R7cLrrQe/996O+ai3ujQOskpTNULa7jOjXXj99eCd8lHvoFiwsbTdZ0a78PrrwTvlo966pLuRtB2fFe3Cm6oHP9kNH/W2FryxtN1nTLvwRurBO+Kj3pWXHidtx2dFu/Bm68Fb81HvykuPlrb7LGkX3mw9eGs+6h1Y8MbSdjegXcguQLjmevDpTQLMxtJ2N6NdyBZu9AbrwVvwUW+LbteULUpCdqm0HTelXbhNPe8G68Gb8lFvVfYfSNuxvrTdTWoXbozAzdaDZzfkorOj1oxVxlIMlpSIlpLrt8D4hrQL17z+c3h6hU/wv4Q/utps4+bm+6P/hIcf0JwQ5oQGPBL0eKPTYEXTW+eL/2DKn73J9BTXYANG57hz1cEMviVf/4tf5b/6C5pTQkMIWoAq7hTpOJjtAM4pxKu5vg5vXeUrtI09/Mo/5H+4z+Mp5xULh7cEm2QbRP2tFIKR7WM3fPf/jZ3SWCqLM2l4NxID5zB72HQXv3jj/8mLR5xXNA5v8EbFQEz7PpRfl1+MB/hlAN65qgDn3wTgH13hK7T59bmP+NIx1SHHU84nLOITt3iVz8mNO+lPrjGAnBFqmioNn1mTyk1ta47R6d4MrX7tjrnjYUpdUbv2rVr6YpVfsGG58AG8Ah9eyUN8CX4WfgV+G8LVWPDGb+Zd4cU584CtqSbMKxauxTg+dyn/LkVgA+IR8KHtejeFKRtTmLLpxN6mYVLjYxwXf5x2VofiZcp/lwKk4wGOpYDnoIZPdg/AAbwMfx0+ge9dgZvYjuqKe4HnGnykYo5TvJbG0Vj12JagRhwKa44H95ShkZa5RyLGGdfYvG7aw1TsF6iapPAS29mNS3NmsTQZCmgTzFwgL3upCTgtBTRwvGMAKrgLn4evwin8+afJRcff+8izUGUM63GOOuAs3tJkw7J4kyoNreqrpO6cYLQeFUd7TTpr5YOTLc9RUUogUOVJQ1GYJaFLAW0oTmKyYS46ZooP4S4EON3xQ5zC8/CX4CnM4c1PE8ApexpoYuzqlP3d4S3OJP8ZDK7cKWNaTlqmgDiiHwl1YsE41w1zT4iRTm3DBqxvOUsbMKKDa/EHxagtnta072ejc3DOIh5ojvh8l3tk1JF/AV6FU6jh3U8HwEazLgdCLYSQ+MYiAI2ltomkzttUb0gGHdSUUgsIYjTzLG3mObX4FBRaYtpDVNZrih9TgTeYOBxsEnN1gOCTM8Bsw/ieMc75w9kuAT6A+/AiHGvN/+Gn4KRkiuzpNNDYhDGFndWRpE6SVfm8U5bxnSgVV2jrg6JCKmneqey8VMFgq2+AM/i4L4RUbfSi27lNXZ7R7W9RTcq/q9fk4Xw3AMQd4I5ifAZz8FcVtm9SAom/dyN4lczJQW/kC42ZrHgcCoIf1oVMKkVItmMBi9cOeNHGLqOZk+QqQmrbc5YmYgxELUUN35z2iohstgfLIFmcMV7s4CFmI74L9+EFmGsi+tGnAOD4Yk9gIpo01Y4cA43BWGygMdr4YZekG3OBIUXXNukvJS8tqa06e+lSDCtnqqMFu6hWHXCF+WaYt64m9QBmNxi7Ioy7D+fa1yHw+FMAcPt7SysFLtoG4PXAk7JOA3aAxBRqUiAdU9Yp5lK3HLSRFtOim0sa8euEt08xvKjYjzeJ2GU7YawexrnKI9tmobInjFXCewpwriY9+RR4aaezFhMhGCppKwom0ChrgFlKzyPKkGlTW1YQrE9HJqu8hKGgMc6hVi5QRq0PZxNfrYNgE64utmRv6KKHRpxf6VDUaOvNP5jCEx5q185My/7RKz69UQu2im5k4/eownpxZxNLwiZ1AZTO2ZjWjkU9uaB2HFn6Q3u0JcsSx/qV9hTEApRzeBLDJQXxYmTnq7bdLa3+uqFrxLJ5w1TehnNHx5ECvCh2g2c3hHH5YsfdaSKddztfjQ6imKFGSyFwlLzxEGPp6r5IevVjk1AMx3wMqi1NxDVjLBiPs9tbsCkIY5we5/ML22zrCScFxnNtzsr9Wcc3CnD+pYO+4VXXiDE0oc/vQQ/fDK3oPESJMYXNmJa/DuloJZkcTpcYE8lIH8Dz8DJMiynNC86Mb2lNaaqP/+L7f2fcE/yP7/Lde8xfgSOdMxvOixZf/9p3+M4hT1+F+zApxg9XfUvYjc8qX2lfOOpK2gNRtB4flpFu9FTKCp2XJRgXnX6olp1zyYjTKJSkGmLE2NjUr1bxFM4AeAAHBUFIeSLqXR+NvH/M9fOnfHzOD2vCSyQJKzfgsCh+yi/Mmc35F2fUrw7miW33W9hBD1vpuUojFphIyvg7aTeoymDkIkeW3XLHmguMzbIAJejN6B5MDrhipE2y6SoFRO/AK/AcHHZHNIfiWrEe/C6cr3f/yOvrQKB+zMM55/GQdLDsR+ifr5Fiuu+/y+M78LzOE5dsNuXC3PYvYWd8NXvphLSkJIasrlD2/HOqQ+RjcRdjKTGWYhhVUm4yxlyiGPuMsZR7sMCHUBeTuNWA7if+ifXgc/hovftHXs/DV+Fvwe+f8shzMiMcweFgBly3//vwJfg5AN4450fn1Hd1Rm1aBLu22Dy3y3H2+OqMemkbGZ4jozcDjJf6596xOLpC0eMTHbKnxLxH27uZ/bMTGs2jOaMOY4m87CfQwF0dw53oa1k80JRuz/XgS+8fX3N9Af4qPIMfzKgCp4H5TDGe9GGeFPzSsZz80SlPTxXjgwJmC45njzgt2vbQ4b4OAdUK4/vWhO8d8v6EE8fMUsfakXbPpFJeLs2ubM/qdm/la3WP91uWhxXHjoWhyRUq2iJ/+5mA73zwIIo+LoZ/SgvIRjAd1IMvvn98PfgOvAJfhhm8scAKVWDuaRaK8aQ9f7vuPDH6Bj47ZXau7rqYJ66mTDwEDU6lLbCjCK0qTXyl5mnDoeNRxanj3FJbaksTk0faXxHxLrssgPkWB9LnA/MFleXcJozzjwsUvUG0X/QCve51qkMDXp9mtcyOy3rwBfdvVJK7D6/ACSzg3RoruIq5UDeESfEmVclDxnniU82vxMLtceD0hGZWzBNPMM/jSPne2OVatiTKUpY5vY7gc0LdUAWeWM5tH+O2I66AOWw9xT2BuyRVLGdoDHUsVRXOo/c+ZdRXvFfnxWyIV4upFLCl9eAL7h8Zv0QH8Ry8pA2cHzQpGesctVA37ZtklBTgHjyvdSeKY/RZw/kJMk0Y25cSNRWSigQtlULPTw+kzuJPeYEkXjQRpoGZobYsLF79pyd1dMRHInbgFTZqNLhDqiIsTNpoex2WLcy0/X6rHcdMMQvFSd5dWA++4P7xv89deACnmr36uGlL69bRCL6BSZsS6c0TU2TKK5gtWCzgAOOwQcurqk9j8whvziZSMLcq5hbuwBEsYjopUBkqw1yYBGpLA97SRElEmx5MCInBY5vgLk94iKqSWmhIGmkJ4Bi9m4L645J68LyY4wsFYBfUg5feP/6gWWm58IEmKQM89hq7KsZNaKtP5TxxrUZZVkNmMJtjbKrGxLNEbHPJxhqy7lAmbC32ZqeF6lTaknRWcYaFpfLUBh/rwaQycCCJmW15Kstv6jRHyJFry2C1ahkkIW0LO75s61+owxK1y3XqweX9m5YLM2DPFeOjn/iiqCKJ+yKXF8t5Yl/kNsqaSCryxPq5xWTFIaP8KSW0RYxqupaUf0RcTNSSdJZGcKYdYA6kdtrtmyBckfKXwqk0pHpUHlwWaffjNRBYFPUDWa8e3Lt/o0R0CdisKDM89cX0pvRHEfM8ca4t0s2Xx4kgo91MPQJ/0c9MQYq0co8MBh7bz1fio0UUHLR4aAIOvOmoYO6kwlEVODSSTliWtOtH6sPkrtctF9ZtJ9GIerBskvhdVS5cFNv9s1BU0AbdUgdK4FG+dRnjFmDTzniRMdZO1QhzMK355vigbdkpz9P6qjUGE5J2qAcXmwJ20cZUiAD0z+pGMx6xkzJkmEf40Hr4qZfVg2XzF9YOyoV5BjzVkUJngKf8lgNYwKECEHrCNDrWZzMlflS3yBhr/InyoUgBc/lKT4pxVrrC6g1YwcceK3BmNxZcAtz3j5EIpqguh9H6wc011YN75cKDLpFDxuwkrPQmUwW4KTbj9mZTwBwLq4aQMUZbHm1rylJ46dzR0dua2n3RYCWZsiHROeywyJGR7mXKlpryyCiouY56sFkBWEnkEB/raeh/Sw4162KeuAxMQpEkzy5alMY5wamMsWKKrtW2WpEWNnReZWONKWjrdsKZarpFjqCslq773PLmEhM448Pc3+FKr1+94vv/rfw4tEcu+lKTBe4kZSdijBrykwv9vbCMPcLQTygBjzVckSLPRVGslqdunwJ4oegtFOYb4SwxNgWLCmD7T9kVjTv5YDgpo0XBmN34Z/rEHp0sgyz7lngsrm4lvMm2Mr1zNOJYJ5cuxuQxwMGJq/TP5emlb8fsQBZviK4t8hFL+zbhtlpwaRSxQRWfeETjuauPsdGxsBVdO7nmP4xvzSoT29pRl7kGqz+k26B3Oy0YNV+SXbbQas1ctC/GarskRdFpKczVAF1ZXnLcpaMuzVe6lZ2g/1ndcvOVgRG3sdUAY1bKD6achijMPdMxV4muKVorSpiDHituH7rSTs7n/4y5DhRXo4FVBN4vO/zbAcxhENzGbHCzU/98Mcx5e7a31kWjw9FCe/zNeYyQjZsWb1uc7U33pN4Mji6hCLhivqfa9Ss6xLg031AgfesA/l99m9fgvnaF9JoE6bYKmkGNK3aPbHB96w3+DnxFm4hs0drLsk7U8kf/N/CvwQNtllna0rjq61sH8L80HAuvwH1tvBy2ChqWSCaYTaGN19sTvlfzFD6n+iKTbvtayfrfe9ueWh6GJFoxLdr7V72a5ZpvHcCPDzma0wTO4EgbLyedxstO81n57LYBOBzyfsOhUKsW1J1BB5vr/tz8RyqOFylQP9Tvst2JALsC5lsH8PyQ40DV4ANzYa4dedNiKNR1s+x2wwbR7q4/4cTxqEk4LWDebfisuo36JXLiWFjOtLrlNWh3K1rRS4xvHcDNlFnNmWBBAl5SWaL3oPOfnvbr5pdjVnEaeBJSYjuLEkyLLsWhKccadmOphZkOPgVdalj2QpSmfOsADhMWE2ZBu4+EEJI4wKTAuCoC4xwQbWXBltpxbjkXJtKxxabo9e7tyhlgb6gNlSbUpMh+l/FaqzVwewGu8BW1Zx7pTpQDJUjb8tsUTW6+GDXbMn3mLbXlXJiGdggxFAoUrtPS3wE4Nk02UZG2OOzlk7fRs7i95QCLo3E0jtrjnM7SR3uS1p4qtS2nJ5OwtQVHgOvArLBFijZUV9QtSl8dAY5d0E0hM0w3HS2DpIeB6m/A1+HfhJcGUq4sOxH+x3f5+VO+Ds9rYNI7zPXOYWPrtf8bYMx6fuOAX5jzNR0PdsuON+X1f7EERxMJJoU6GkTEWBvVolVlb5lh3tKCg6Wx1IbaMDdJ+9sUCc5KC46hKGCk3IVOS4TCqdBNfUs7Kd4iXf2RjnT/LLysJy3XDcHLh/vde3x8DoGvwgsa67vBk91G5Pe/HbOe7xwym0NXbtiuuDkGO2IJDh9oQvJ4cY4vdoqLDuoH9Zl2F/ofsekn8lkuhIlhQcffUtSjytFyp++p6NiE7Rqx/lodgKVoceEp/CP4FfjrquZaTtj2AvH5K/ywpn7M34K/SsoYDAdIN448I1/0/wveW289T1/lX5xBzc8N5IaHr0XMOQdHsIkDuJFifj20pBm5jzwUv9e2FhwRsvhAbalCIuIw3bhJihY3p6nTFFIZgiSYjfTf3aXuOjmeGn4bPoGvwl+CFzTRczBIuHBEeImHc37/lGfwZR0cXzVDOvaKfNHvwe+suZ771K/y/XcBlsoN996JpBhoE2toYxOznNEOS5TJc6Id5GEXLjrWo+LEWGNpPDU4WAwsIRROu+1vM+0oW37z/MBN9kqHnSArwPfgFJ7Cq/Ai3Ie7g7ncmI09v8sjzw9mzOAEXoIHxURueaAce5V80f/DOuuZwHM8vsMb5wBzOFWM7wymTXPAEvm4vcFpZ2ut0VZRjkiP2MlmLd6DIpbGSiHOjdnUHN90hRYmhTnmvhzp1iKDNj+b7t5hi79lWGwQ+HN9RsfFMy0FXbEwhfuczKgCbyxYwBmcFhhvo/7a44v+i3XWcwDP86PzpGQYdWh7csP5dBvZ1jNzdxC8pBGuxqSW5vw40nBpj5JhMwvOzN0RWqERHMr4Lv1kWX84xLR830G3j6yqZ1a8UstTlW+qJPOZ+sZ7xZPKTJLhiNOAFd6tk+jrTH31ncLOxid8+nzRb128HhUcru/y0Wn6iT254YPC6FtVSIMoW2sk727AhvTtrWKZTvgsmckfXYZWeNRXx/3YQ2OUxLDrbHtN11IwrgXT6c8dATDwLniYwxzO4RzuQqTKSC5gAofMZ1QBK3zQ4JWobFbcvJm87FK+6JXrKahLn54m3p+McXzzYtP8VF/QpJuh1OwieElEoI1pRxPS09FBrkq2tWCU59+HdhNtTIqKm8EBrw2RTOEDpG3IKo2Y7mFdLm3ZeVjYwVw11o/oznceMve4CgMfNym/utA/d/ILMR7gpXzRy9eDsgLcgbs8O2Va1L0zzIdwGGemTBuwROHeoMShkUc7P+ISY3KH5ZZeWqO8mFTxQYeXTNuzvvK5FGPdQfuu00DwYFY9dyhctEt+OJDdnucfpmyhzUJzfsJjr29l8S0bXBfwRS9ZT26tmMIdZucch5ZboMz3Nio3nIOsYHCGoDT4kUA9MiXEp9Xsui1S8th/kbWIrMBxDGLodWUQIWcvnXy+9M23xPiSMOiRPqM+YMXkUN3gXFrZJwXGzUaMpJfyRS9ZT0lPe8TpScuRlbMHeUmlaKDoNuy62iWNTWNFYjoxFzuJs8oR+RhRx7O4SVNSXpa0ZJQ0K1LAHDQ+D9IepkMXpcsq5EVCvClBUIzDhDoyKwDw1Lc59GbTeORivugw1IcuaEOaGWdNm+Ps5fQ7/tm0DjMegq3yM3vb5j12qUId5UZD2oxDSEWOZMSqFl/W+5oynWDa/aI04tJRQ2eTXusg86SQVu/nwSYwpW6wLjlqIzwLuxGIvoAvul0PS+ZNz0/akp/pniO/8JDnGyaCkzbhl6YcqmK/69prxPqtpx2+Km9al9sjL+rwMgHw4jE/C8/HQ3m1vBuL1fldbzd8mOueVJ92syqdEY4KJjSCde3mcRw2TA6szxedn+zwhZMps0XrqEsiUjnC1hw0TELC2Ek7uAAdzcheXv1BYLagspxpzSAoZZUsIzIq35MnFQ9DOrlNB30jq3L4pkhccKUAA8/ocvN1Rzx9QyOtERs4CVsJRK/DF71kPYrxYsGsm6RMh4cps5g1DOmM54Ly1ii0Hd3Y/BMk8VWFgBVmhqrkJCPBHAolwZaWzLR9Vb7bcWdX9NyUYE+uB2BKfuaeBUcjDljbYVY4DdtsVWvzRZdWnyUzDpjNl1Du3aloAjVJTNDpcIOVVhrHFF66lLfJL1zJr9PQ2nFJSBaKoDe+sAvLufZVHVzYh7W0h/c6AAZ+7Tvj6q9j68G/cTCS/3n1vLKHZwNi+P+pS0WkZNMBMUl+LDLuiE4omZy71r3UFMwNJV+VJ/GC5ixVUkBStsT4gGKh0Gm4Oy3qvq7Lbmq24nPdDuDR9deR11XzP4vFu3TYzfnIyiSVmgizUYGqkIXNdKTY9pgb9D2Ix5t0+NHkVzCdU03suWkkVZAoCONCn0T35gAeW38de43mf97sMOpSvj4aa1KYUm58USI7Wxxes03bAZdRzk6UtbzMaCQ6IxO0dy7X+XsjoD16hpsBeGz9dfzHj+R/Hp8nCxZRqkEDTaCKCSywjiaoMJ1TITE9eg7Jqnq8HL6gDwiZb0u0V0Rr/rmvqjxKuaLCX7ZWXTvAY+uvm3z8CP7nzVpngqrJpZKwWnCUjIviYVlirlGOzPLI3SMVyp/elvBUjjDkNhrtufFFErQ8pmdSlbK16toBHlt/HV8uHMX/vEGALkV3RJREiSlopxwdMXOZPLZ+ix+kAHpMKIk8UtE1ygtquttwxNhphrIZ1IBzjGF3IIGxGcBj6q8bHJBG8T9vdsoWrTFEuebEZuVxhhClH6P5Zo89OG9fwHNjtNQTpD0TG9PJLEYqvEY6Rlxy+ZZGfL0Aj62/bnQCXp//eeM4KzfQVJbgMQbUjlMFIm6TpcfWlZje7NBSV6IsEVmumWIbjiloUzQX9OzYdo8L1wjw2PrrpimONfmfNyzKklrgnEkSzT5QWYQW40YShyzqsRmMXbvVxKtGuYyMKaU1ugenLDm5Ily4iT14fP11Mx+xJv+zZ3MvnfdFqxU3a1W/FTB4m3Qfsyc1XUcdVhDeUDZXSFHHLQj/Y5jtC7ZqM0CXGwB4bP11i3LhOvzPGygYtiUBiwQV/4wFO0majijGsafHyRLu0yG6q35cL1rOpVxr2s5cM2jJYMCdc10Aj6q/blRpWJ//+dmm5psMl0KA2+AFRx9jMe2WbC4jQxnikd4DU8TwUjRVacgdlhmr3bpddzuJ9zXqr2xnxJfzP29RexdtjDVZqzkqa6PyvcojGrfkXiJ8SEtml/nYskicv0ivlxbqjemwUjMw5evdg8fUX9nOiC/lf94Q2i7MURk9nW1MSj5j8eAyV6y5CN2S6qbnw3vdA1Iwq+XOSCl663udN3IzLnrt+us25cI1+Z83SXQUldqQq0b5XOT17bGpLd6ssN1VMPf8c+jG8L3NeCnMdF+Ra3fRa9dft39/LuZ/3vwHoHrqGmQFafmiQw6eyzMxS05K4bL9uA+SKUQzCnSDkqOGokXyJvbgJ/BHI+qvY69//4rl20NsmK2ou2dTsyIALv/91/8n3P2Aao71WFGi8KKv1fRC5+J67Q/507/E/SOshqN5TsmYIjVt+kcjAx98iz/4SaojbIV1rexE7/C29HcYD/DX4a0rBOF5VTu7omsb11L/AWcVlcVZHSsqGuXLLp9ha8I//w3Mv+T4Ew7nTBsmgapoCrNFObIcN4pf/Ob/mrvHTGqqgAupL8qWjWPS9m/31jAe4DjA+4+uCoQoT/zOzlrNd3qd4SdphFxsUvYwGWbTWtISc3wNOWH+kHBMfc6kpmpwPgHWwqaSUG2ZWWheYOGQGaHB+eQ/kn6b3pOgLV+ODSn94wDvr8Bvb70/LLuiPPEr8OGVWfDmr45PZyccEmsVXZGe1pRNX9SU5+AVQkNTIVPCHF/jGmyDC9j4R9LfWcQvfiETmgMMUCMN1uNCakkweZsowdYobiMSlnKA93u7NzTXlSfe+SVbfnPQXmg9LpYAQxpwEtONyEyaueWM4FPjjyjG3uOaFmBTWDNgBXGEiQpsaWhnAqIijB07Dlsy3fUGeP989xbWkyf+FF2SNEtT1E0f4DYYVlxFlbaSMPIRMk/3iMU5pME2SIWJvjckciebkQuIRRyhUvkHg/iUljG5kzVog5hV7vIlCuBrmlhvgPfNHQM8lCf+FEGsYbMIBC0qC9a0uuy2wLXVbLBaP5kjHokCRxapkQyzI4QEcwgYHRZBp+XEFTqXFuNVzMtjXLJgX4gAid24Hjwc4N3dtVSe+NNiwTrzH4WVUOlDobUqr1FuAgYllc8pmzoVrELRHSIW8ViPxNy4xwjBpyR55I6J220qQTZYR4guvUICJiSpr9gFFle4RcF/OMB7BRiX8sSfhpNSO3lvEZCQfLUVTKT78Ek1LRLhWN+yLyTnp8qWUZ46b6vxdRGXfHVqx3eI75YaLa4iNNiK4NOW7wPW6lhbSOF9/M9qw8e/aoB3d156qTzxp8pXx5BKAsYSTOIIiPkp68GmTq7sZtvyzBQaRLNxIZ+paozHWoLFeExIhRBrWitHCAHrCF7/thhD8JhYz84wg93QRV88wLuLY8zF8sQ36qF1J455bOlgnELfshKVxYOXKVuKx0jaj22sczTQqPqtV/XDgpswmGTWWMSDw3ssyUunLLrVPGjYRsH5ggHeHSWiV8kT33ycFSfMgkoOK8apCye0J6VW6GOYvffgU9RWsukEi2kUV2nl4dOYUzRik9p7bcA4ggdJ53LxKcEe17B1R8eqAd7dOepV8sTXf5lhejoL85hUdhDdknPtKHFhljOT+bdq0hxbm35p2nc8+Ja1Iw+tJykgp0EWuAAZYwMVwac5KzYMslhvgHdHRrxKnvhTYcfKsxTxtTETkjHO7rr3zjoV25lAQHrqpV7bTiy2aXMmUhTBnKS91jhtR3GEoF0oLnWhWNnYgtcc4N0FxlcgT7yz3TgNIKkscx9jtV1ZKpWW+Ub1tc1eOv5ucdgpx+FJy9pgbLE7xDyXb/f+hLHVGeitHOi6A7ybo3sF8sS7w7cgdk0nJaOn3hLj3uyD0Zp5pazFIUXUpuTTU18d1EPkDoX8SkmWTnVIozEdbTcZjoqxhNHf1JrSS/AcvHjZ/SMHhL/7i5z+POsTUh/8BvNfYMTA8n+yU/MlTZxSJDRStqvEuLQKWwDctMTQogUDyQRoTQG5Kc6oQRE1yV1jCA7ri7jdZyK0sYTRjCR0Hnnd+y7nHxNgTULqw+8wj0mQKxpYvhjm9uSUxg+TTy7s2GtLUGcywhXSKZN275GsqlclX90J6bRI1aouxmgL7Q0Nen5ziM80SqMIo8cSOo+8XplT/5DHNWsSUr/6lLN/QQ3rDyzLruEW5enpf7KqZoShEduuSFOV7DLX7Ye+GmXb6/hnNNqKsVXuMDFpb9Y9eH3C6NGEzuOuI3gpMH/I6e+zDiH1fXi15t3vA1czsLws0TGEtmPEJdiiFPwlwKbgLHAFk4P6ZyPdymYYHGE0dutsChQBl2JcBFlrEkY/N5bQeXQ18gjunuMfMfsBlxJSx3niO485fwO4fGD5T/+3fPQqkneWVdwnw/3bMPkW9Wbqg+iC765Zk+xcT98ibKZc2EdgHcLoF8cSOo/Oc8fS+OyEULF4g4sJqXVcmfMfsc7A8v1/yfGXmL9I6Fn5pRwZhsPv0TxFNlAfZCvG+Oohi82UC5f/2IsJo0cTOm9YrDoKhFPEUr/LBYTUNht9zelHXDqwfPCIw4owp3mOcIQcLttWXFe3VZ/j5H3cIc0G6oPbCR+6Y2xF2EC5cGUm6wKC5tGEzhsWqw5hNidUiKX5gFWE1GXh4/Qplw4sVzOmx9QxU78g3EF6wnZlEN4FzJ1QPSLEZz1KfXC7vd8ssGdIbNUYpVx4UapyFUHzJoTOo1McSkeNn1M5MDQfs4qQuhhX5vQZFw8suwWTcyYTgioISk2YdmkhehG4PkE7w51inyAGGaU+uCXADabGzJR1fn3lwkty0asIo8cROm9Vy1g0yDxxtPvHDAmpu+PKnM8Ix1wwsGw91YJqhteaWgjYBmmQiebmSpwKKzE19hx7jkzSWOm66oPbzZ8Yj6kxVSpYjVAuvLzYMCRo3oTQecOOjjgi3NQ4l9K5/hOGhNTdcWVOTrlgYNkEXINbpCkBRyqhp+LdRB3g0OU6rMfW2HPCFFMV9nSp+uB2woepdbLBuJQyaw/ZFysXrlXwHxI0b0LovEkiOpXGA1Ijagf+KUNC6rKNa9bQnLFqYNkEnMc1uJrg2u64ELPBHpkgWbmwKpJoDhMwNbbGzAp7Yg31wS2T5rGtzit59PrKhesWG550CZpHEzpv2NGRaxlNjbMqpmEIzygJqQfjypycs2pg2cS2RY9r8HUqkqdEgKTWtWTKoRvOBPDYBltja2SO0RGjy9UHtxwRjA11ujbKF+ti5cIR9eCnxUg6owidtyoU5tK4NLji5Q3HCtiyF2IqLGYsHViOXTXOYxucDqG0HyttqYAKqYo3KTY1ekyDXRAm2AWh9JmsVh/ccg9WJ2E8YjG201sPq5ULxxX8n3XLXuMInbft2mk80rRGjCGctJ8/GFdmEQ9Ug4FlE1ll1Y7jtiraqm5Fe04VV8lvSVBL8hiPrfFVd8+7QH3Qbu2ipTVi8cvSGivc9cj8yvH11YMHdNSERtuOslM97feYFOPKzGcsI4zW0YGAbTAOaxCnxdfiYUmVWslxiIblCeAYr9VYR1gM7GmoPrilunSxxeT3DN/2eBQ9H11+nk1adn6VK71+5+Jfct4/el10/7KBZfNryUunWSCPxPECk1rdOv1WVSrQmpC+Tl46YD3ikQYcpunSQgzVB2VHFhxHVGKDgMEY5GLlQnP7FMDzw7IacAWnO6sBr12u+XanW2AO0wQ8pknnFhsL7KYIqhkEPmEXFkwaN5KQphbkUmG72wgw7WSm9RiL9QT925hkjiVIIhphFS9HKI6/8QAjlpXqg9W2C0apyaVDwKQwrwLY3j6ADR13ZyUNByQXHQu6RY09Hu6zMqXRaNZGS/KEJs0cJEe9VH1QdvBSJv9h09eiRmy0V2uJcqHcShcdvbSNg5fxkenkVprXM9rDVnX24/y9MVtncvbKY706anNl3ASll9a43UiacVquXGhvq4s2FP62NGKfQLIQYu9q1WmdMfmUrDGt8eDS0cXozH/fjmUH6Jruvm50hBDSaEU/2Ru2LEN/dl006TSc/g7tfJERxGMsgDUEr104pfWH9lQaN+M4KWQjwZbVc2rZVNHsyHal23wZtIs2JJqtIc/WLXXRFCpJkfE9jvWlfFbsNQ9pP5ZBS0zKh4R0aMFj1IjTcTnvi0Zz2rt7NdvQb2mgbju1plsH8MmbnEk7KbK0b+wC2iy3aX3szW8xeZvDwET6hWZYwqTXSSG+wMETKum0Dq/q+x62gt2ua2ppAo309TRk9TPazfV3qL9H8z7uhGqGqxNVg/FKx0HBl9OVUORn8Q8Jx9gFttGQUDr3tzcXX9xGgN0EpzN9mdZ3GATtPhL+CjxFDmkeEU6x56kqZRusLzALXVqkCN7zMEcqwjmywDQ6OhyUe0Xao1Qpyncrg6wKp9XfWDsaZplElvQ/b3sdweeghorwBDlHzgk1JmMc/wiERICVy2VJFdMjFuLQSp3S0W3+sngt2njwNgLssFGVQdJ0tu0KH4ky1LW4yrbkuaA6Iy9oz/qEMMXMMDWyIHhsAyFZc2peV9hc7kiKvfULxCl9iddfRK1f8kk9qvbdOoBtOg7ZkOZ5MsGrSHsokgLXUp9y88smniwWyuFSIRVmjplga3yD8Uij5QS1ZiM4U3Qw5QlSm2bXjFe6jzzBFtpg+/YBbLAWG7OPynNjlCw65fukGNdkJRf7yM1fOxVzbxOJVocFoYIaGwH22mIQkrvu1E2nGuebxIgW9U9TSiukPGU+Lt++c3DJPKhyhEEbXCQLUpae2exiKy6tMPe9mDRBFCEMTWrtwxN8qvuGnt6MoihKWS5NSyBhbH8StXoAz8PLOrRgLtOT/+4vcu+7vDLnqNvztOq7fmd8sMmY9Xzn1zj8Dq8+XVdu2Nv0IIySgEdQo3xVHps3Q5i3fLFsV4aiqzAiBhbgMDEd1uh8qZZ+lwhjkgokkOIv4xNJmyncdfUUzgB4oFMBtiu71Xumpz/P+cfUP+SlwFExwWW62r7b+LSPxqxn/gvMZ5z9C16t15UbNlq+jbGJtco7p8wbYlL4alSyfWdeuu0j7JA3JFNuVAwtst7F7FhWBbPFNKIUORndWtLraFLmMu7KFVDDOzqkeaiN33YAW/r76wR4XDN/yN1z7hejPau06EddkS/6XThfcz1fI/4K736fO48vlxt2PXJYFaeUkFS8U15XE3428xdtn2kc8GQlf1vkIaNRRnOMvLTWrZbElEHeLWi1o0dlKPAh1MVgbbVquPJ5+Cr8LU5/H/+I2QlHIU2ClXM9G8v7Rr7oc/hozfUUgsPnb3D+I+7WF8kNO92GY0SNvuxiE+2Bt8prVJTkzE64sfOstxuwfxUUoyk8VjcTlsqe2qITSFoSj6Epd4KsT6BZOWmtgE3hBfir8IzZDwgV4ZTZvD8VvPHERo8v+vL1DASHTz/i9OlKueHDjK5Rnx/JB1Vb1ioXdBra16dmt7dgik10yA/FwJSVY6XjA3oy4SqM2frqDPPSRMex9qs3XQtoWxMj7/Er8GWYsXgjaVz4OYumP2+9kbxvny/6kvWsEBw+fcb5bInc8APdhpOSs01tEqIkoiZjbAqKMruLbJYddHuHFRIyJcbdEdbl2sVLaySygunutBg96Y2/JjKRCdyHV+AEFtTvIpbKIXOamknYSiB6KV/0JetZITgcjjk5ZdaskBtWO86UF0ap6ozGXJk2WNiRUlCPFir66lzdm/SLSuK7EUdPz8f1z29Skq6F1fXg8+5UVR6bszncP4Tn4KUkkdJ8UFCY1zR1i8RmL/qQL3rlei4THG7OODlnKko4oI01kd3CaM08Ia18kC3GNoVaO9iDh+hWxSyTXFABXoau7Q6q9OxYg/OVEMw6jdbtSrJ9cBcewGmaZmg+bvkUnUUaGr+ZfnMH45Ivevl61hMcXsxYLFTu1hTm2zViCp7u0o5l+2PSUh9bDj6FgYypufBDhqK2+oXkiuHFHR3zfj+9PtA8oR0xnqX8qn+sx3bFODSbbF0X8EUvWQ8jBIcjo5bRmLOljDNtcqNtOe756h3l0VhKa9hDd2l1eqmsnh0MNMT/Cqnx6BInumhLT8luljzQ53RiJeA/0dxe5NK0o2fA1+GLXr6eNQWHNUOJssQaTRlGpLHKL9fD+IrQzTOMZS9fNQD4AnRNVxvTdjC+fJdcDDWQcyB00B0t9BDwTxXgaAfzDZ/DBXzRnfWMFRwuNqocOmX6OKNkY63h5n/fFcB28McVHqnXZVI27K0i4rDLNE9lDKV/rT+udVbD8dFFu2GGZ8mOt0kAXcoX3ZkIWVtw+MNf5NjR2FbivROHmhV1/pj2egv/fMGIOWTIWrV3Av8N9imV9IWml36H6cUjqEWNv9aNc+veb2sH46PRaHSuMBxvtW+twxctq0z+QsHhux8Q7rCY4Ct8lqsx7c6Sy0dl5T89rIeEuZKoVctIk1hNpfavER6yyH1Vvm3MbsUHy4ab4hWr/OZPcsRBphnaV65/ZcdYPNNwsjN/djlf9NqCw9U5ExCPcdhKxUgLSmfROpLp4WSUr8ojdwbncbvCf+a/YzRaEc6QOvXcGO256TXc5Lab9POvB+AWY7PigWYjzhifbovuunzRawsO24ZqQQAqguBtmpmPB7ysXJfyDDaV/aPGillgz1MdQg4u5MYaEtBNNHFjkRlSpd65lp4hd2AVPTfbV7FGpyIOfmNc/XVsPfg7vzaS/3nkvLL593ANLvMuRMGpQIhiF7kUEW9QDpAUbTWYBcbp4WpacHHY1aacqQyjGZS9HI3yCBT9kUZJhVOD+zUDvEH9ddR11fzPcTDQ5TlgB0KwqdXSavk9BC0pKp0WmcuowSw07VXmXC5guzSa4p0UvRw2lbDiYUx0ExJJRzWzi6Gm8cnEkfXXsdcG/M/jAJa0+bmCgdmQ9CYlNlSYZOKixmRsgiFxkrmW4l3KdFKv1DM8tk6WxPYJZhUUzcd8Kdtgrw/gkfXXDT7+avmfVak32qhtkg6NVdUS5wgkru1YzIkSduTW1FDwVWV3JQVJVuieTc0y4iDpFwc7/BvSalvKdQM8sv662cevz/+8sQVnjVAT0W2wLllw1JiMhJRxgDjCjLQsOzSFSgZqx7lAW1JW0e03yAD3asC+GD3NbQhbe+mN5GXH1F83KDOM4n/e5JIuH4NpdQARrFPBVptUNcjj4cVMcFSRTE2NpR1LEYbYMmfWpXgP9KejaPsLUhuvLCsVXznAG9dfx9SR1ud/3hZdCLHb1GMdPqRJgqDmm76mHbvOXDtiO2QPUcKo/TWkQ0i2JFXpBoo7vij1i1Lp3ADAo+qvG3V0rM//vFnnTE4hxd5Ka/Cor5YEdsLVJyKtDgVoHgtW11pWSjolPNMnrlrVj9Fv2Qn60twMwKPqr+N/wvr8z5tZcDsDrv06tkqyzESM85Ycv6XBWA2birlNCXrI6VbD2lx2L0vQO0QVTVVLH4SE67fgsfVXv8n7sz7/85Z7cMtbE6f088wSaR4kCkCm10s6pKbJhfqiUNGLq+0gLWC6eUAZFPnLjwqtKd8EwGvWX59t7iPW4X/eAN1svgRVSY990YZg06BD1ohLMtyFTI4pKTJsS9xREq9EOaPWiO2gpms7397x6nQJkbh+Fz2q/rqRROX6/M8bJrqlVW4l6JEptKeUFuMYUbtCQ7CIttpGc6MY93x1r1vgAnRXvY5cvwWPqb9uWQm+lP95QxdNMeWhOq1x0Db55C7GcUv2ZUuN6n8iKzsvOxibC//Yfs9Na8r2Rlz02vXXDT57FP/zJi66/EJSmsJKa8QxnoqW3VLQ+jZVUtJwJ8PNX1NQCwfNgdhhHD9on7PdRdrdGPF28rJr1F+3LBdeyv+8yYfLoMYet1vX4upNAjVvwOUWnlNXJXlkzk5Il6kqeoiL0C07qno+/CYBXq/+utlnsz7/Mzvy0tmI4zm4ag23PRN3t/CWryoUVJGm+5+K8RJ0V8Hc88/XHUX/HfiAq7t+BH+x6v8t438enWmdJwFA6ZINriLGKv/95f8lT9/FnyA1NMVEvQyaXuu+gz36f/DD73E4pwqpLcvm/o0Vle78n//+L/NPvoefp1pTJye6e4A/D082FERa5/opeH9zpvh13cNm19/4v/LDe5xMWTi8I0Ta0qKlK27AS/v3/r+/x/2GO9K2c7kVMonDpq7//jc5PKCxeNPpFVzaRr01wF8C4Pu76hXuX18H4LduTr79guuFD3n5BHfI+ZRFhY8w29TYhbbLi/bvBdqKE4fUgg1pBKnV3FEaCWOWyA+m3WpORZr/j+9TKJtW8yBTF2/ZEODI9/QavHkVdGFp/Pjn4Q+u5hXapsP5sOH+OXXA1LiKuqJxiMNbhTkbdJTCy4llEt6NnqRT4dhg1V3nbdrm6dYMecA1yTOL4PWTE9L5VzPFlLBCvlG58AhehnN4uHsAYinyJ+AZ/NkVvELbfOBUuOO5syBIEtiqHU1k9XeISX5bsimrkUUhnGDxourN8SgUsCZVtKyGbyGzHXdjOhsAvOAswSRyIBddRdEZWP6GZhNK/yjwew9ehBo+3jEADu7Ay2n8mDc+TS7awUHg0OMzR0LABhqLD4hJEh/BEGyBdGlSJoXYXtr+3HS4ijzVpgi0paWXtdruGTknXBz+11qT1Q2inxaTzQCO46P3lfLpyS4fou2PH/PupwZgCxNhGlj4IvUuWEsTkqMWm6i4xCSMc9N1RDQoCVcuGItJ/MRWefais+3synowi/dESgJjkilnWnBTGvRWmaw8oR15257t7CHmCf8HOn7cwI8+NQBXMBEmAa8PMRemrNCEhLGEhDQKcGZWS319BX9PFBEwGTbRBhLbDcaV3drFcDqk5kCTd2JF1Wp0HraqBx8U0wwBTnbpCadwBA/gTH/CDrcCs93LV8E0YlmmcyQRQnjBa8JESmGUfIjK/7fkaDJpmD2QptFNVJU1bbtIAjjWQizepOKptRjbzR9Kag6xZmMLLjHOtcLT3Tx9o/0EcTT1XN3E45u24AiwEypDJXihKjQxjLprEwcmRKclaDNZCVqr/V8mYWyFADbusiY5hvgFoU2vio49RgJLn5OsReRFN6tabeetiiy0V7KFHT3HyZLx491u95sn4K1QQSPKM9hNT0wMVvAWbzDSVdrKw4zRjZMyJIHkfq1VAVCDl/bUhNKlGq0zGr05+YAceXVPCttVk0oqjVwMPt+BBefx4yPtGVkUsqY3CHDPiCM5ngupUwCdbkpd8kbPrCWHhkmtIKLEetF2499eS1jZlIPGYnlcPXeM2KD9vLS0bW3ktYNqUllpKLn5ZrsxlIzxvDu5eHxzGLctkZLEY4PgSOg2IUVVcUONzUDBEpRaMoXNmUc0tFZrTZquiLyKxrSm3DvIW9Fil+AkhXu5PhEPx9mUNwqypDvZWdKlhIJQY7vn2OsnmBeOWnYZ0m1iwbbw1U60by5om47iHRV6fOgzjMf/DAZrlP40Z7syxpLK0lJ0gqaAK1c2KQKu7tabTXkLFz0sCftuwX++MyNeNn68k5Buq23YQhUh0SNTJa1ioQ0p4nUG2y0XilF1JqODqdImloPS4Bp111DEWT0jJjVv95uX9BBV7eB3bUWcu0acSVM23YZdd8R8UbQUxJ9wdu3oMuhdt929ME+mh6JXJ8di2RxbTi6TbrDquqV4aUKR2iwT6aZbyOwEXN3DUsWr8Hn4EhwNyHuXHh7/pdaUjtR7vnDh/d8c9xD/s5f501eQ1+CuDiCvGhk1AN/4Tf74RfxPwD3toLarR0zNtsnPzmS64KIRk861dMWCU8ArasG9T9H0ZBpsDGnjtAOM2+/LuIb2iIUGXNgl5ZmKD/Tw8TlaAuihaFP5yrw18v4x1898zIdP+DDAX1bM3GAMvPgRP/cJn3zCW013nrhHkrITyvYuwOUkcHuKlRSW5C6rzIdY4ppnF7J8aAJbQepgbJYBjCY9usGXDKQxq7RZfh9eg5d1UHMVATRaD/4BHK93/1iAgYZ/+jqPn8Dn4UExmWrpa3+ZOK6MvM3bjwfzxNWA2dhs8+51XHSPJiaAhGSpWevEs5xHLXcEGFXYiCONySH3fPWq93JIsBiSWvWyc3CAN+EcXoT7rCSANloPPoa31rt/5PUA/gp8Q/jDD3hyrjzlR8VkanfOvB1XPubt17vzxAfdSVbD1pzAnfgyF3ycadOTOTXhpEUoLC1HZyNGW3dtmjeXgr2r56JNmRwdNNWaQVBddd6rh4MhviEB9EFRD/7RGvePvCbwAL4Mx/D6M541hHO4D3e7g6PafdcZVw689z7NGTwo5om7A8sPhccT6qKcl9NJl9aM/9kX+e59Hh1yPqGuCCZxuITcsmNaJ5F7d0q6J3H48TO1/+M57085q2icdu2U+W36Ldllz9Agiv4YGljoEN908EzvDOrBF98/vtJwCC/BF2AG75xxEmjmMIcjxbjoaxqOK3/4hPOZzhMPBpYPG44CM0dTVm1LjLtUWWVz1Bcf8tEx0zs8O2A2YVHRxKYOiy/aOVoAaMu0i7ubu43njjmd4ibMHU1sIDHaQNKrZND/FZYdk54oCXetjq7E7IVl9eAL7t+oHnwXXtLx44czzoRFHBztYVwtH1d+NOMkupZ5MTM+gUmq90X+Bh9zjRlmaQ+m7YMqUL/veemcecAtOJ0yq1JnVlN27di2E0+Klp1tAJ4KRw1eMI7aJjsO3R8kPSI3fUFXnIOfdQe86sIIVtWDL7h//Ok6vj8vwDk08NEcI8zz7OhBy+WwalzZeZ4+0XniRfst9pAJqQHDGLzVQ2pheZnnv1OWhwO43/AgcvAEXEVVpa4db9sGvNK8wjaENHkfFQ4Ci5i7dqnQlPoLQrHXZDvO3BIXZbJOBrOaEbML6sFL798I4FhKihjHMsPjBUZYCMFr6nvaArxqXPn4lCa+cHfSa2cP27g3Z3ziYTRrcbQNGLQmGF3F3cBdzzzX7AILx0IB9rbwn9kx2G1FW3Inic+ZLIsVvKR8Zwfj0l1fkqo8LWY1M3IX14OX3r9RKTIO+d9XzAI8qRPGPn/4NC2n6o4rN8XJ82TOIvuVA8zLKUHRFgBCetlDZlqR1gLKjS39xoE7Bt8UvA6BxuEDjU3tFsEijgA+615tmZkXKqiEENrh41iLDDZNq4pKTWR3LZfnos81LOuNa15cD956vLMsJd1rqYp51gDUQqMYm2XsxnUhD2jg1DM7SeuJxxgrmpfISSXVIJIS5qJJSvJPEQ49DQTVIbYWJ9QWa/E2+c/oPK1drmC7WSfJRNKBO5Yjvcp7Gc3dmmI/Xh1kDTEuiSnWqQf37h+fTMhGnDf6dsS8SQfQWlqqwXXGlc/PEZ/SC5mtzIV0nAshlQdM/LvUtYutrEZ/Y+EAFtq1k28zQhOwLr1AIeANzhF8t9qzTdZf2qRKO6MWE9ohBYwibbOmrFtNmg3mcS+tB28xv2uKd/agYCvOP+GkSc+0lr7RXzyufL7QbkUpjLjEWFLqOIkAGu2B0tNlO9Eau2W1qcOUvVRgKzypKIQZ5KI3q0MLzqTNRYqiZOqmtqloIRlmkBHVpHmRYV6/HixbO6UC47KOFJnoMrVyr7wYz+SlW6GUaghYbY1I6kkxA2W1fSJokUdSh2LQ1GAimRGm0MT+uu57H5l7QgOWxERpO9moLRPgTtquWCfFlGlIjQaRly9odmzMOWY+IBO5tB4sW/0+VWGUh32qYk79EidWKrjWuiLpiVNGFWFRJVktyeXWmbgBBzVl8anPuXyNJlBJOlKLTgAbi/EYHVHxWiDaVR06GnHQNpJcWcK2jJtiCfG2sEHLzuI66sGrMK47nPIInPnu799935aOK2cvmvubrE38ZzZjrELCmXM2hM7UcpXD2oC3+ECVp7xtIuxptJ0jUr3sBmBS47TVxlvJ1Sqb/E0uLdvLj0lLr29ypdd/eMX3f6lrxGlKwKQxEGvw0qHbkbwrF3uHKwVENbIV2wZ13kNEF6zD+x24aLNMfDTCbDPnEikZFyTNttxWBXDaBuM8KtI2rmaMdUY7cXcUPstqTGvBGSrFWIpNMfbdea990bvAOC1YX0qbc6smDS1mPxSJoW4fwEXvjMmhlijDRq6qale6aJEuFGoppYDoBELQzLBuh/mZNx7jkinv0EtnUp50lO9hbNK57lZaMAWuWR5Yo9/kYwcYI0t4gWM47Umnl3YmpeBPqSyNp3K7s2DSAS/39KRuEN2bS4xvowV3dFRMx/VFcp2Yp8w2nTO9hCXtHG1kF1L4KlrJr2wKfyq77R7MKpFKzWlY9UkhYxyHWW6nBWPaudvEAl3CGcNpSXPZ6R9BbBtIl6cHL3gIBi+42CYXqCx1gfGWe7Ap0h3luyXdt1MKy4YUT9xSF01G16YEdWsouW9mgDHd3veyA97H+Ya47ZmEbqMY72oPztCGvK0onL44AvgC49saZKkWRz4veWljE1FHjbRJaWv6ZKKtl875h4CziFCZhG5rx7tefsl0aRT1bMHZjm8dwL/6u7wCRysaQblQoG5yAQN5zpatMNY/+yf8z+GLcH/Qn0iX2W2oEfXP4GvwQHuIL9AYGnaO3zqAX6946nkgqZNnUhx43DIdQtMFeOPrgy/y3Yd85HlJWwjLFkU3kFwq28xPnuPhMWeS+tDLV9Otllq7pQCf3uXJDN9wFDiUTgefHaiYbdfi3b3u8+iY6TnzhgehI1LTe8lcd7s1wJSzKbahCRxKKztTLXstGAiu3a6rPuQs5pk9TWAan5f0BZmGf7Ylxzzk/A7PAs4QPPPAHeFQ2hbFHszlgZuKZsJcUmbDC40sEU403cEjczstOEypa+YxevL4QBC8oRYqWdK6b7sK25tfE+oDZgtOQ2Jg8T41HGcBE6fTWHn4JtHcu9S7uYgU5KSCkl/mcnq+5/YBXOEr6lCUCwOTOM1taOI8mSxx1NsCXBEmLKbMAg5MkwbLmpBaFOPrNSlO2HnLiEqW3tHEwd8AeiQLmn+2gxjC3k6AxREqvKcJbTEzlpLiw4rNZK6oJdidbMMGX9FULKr0AkW+2qDEPBNNm5QAt2Ik2nftNWHetubosHLo2nG4vQA7GkcVCgVCgaDixHqo9UUn1A6OshapaNR/LPRYFV8siT1cCtJE0k/3WtaNSuUZYKPnsVIW0xXWnMUxq5+En4Kvw/MqQmVXnAXj9Z+9zM98zM/Agy7F/qqj2Nh67b8HjFnPP3iBn/tkpdzwEJX/whIcQUXOaikeliCRGUk7tiwF0rItwMEhjkZ309hikFoRAmLTpEXWuHS6y+am/KB/fM50aLEhGnSMwkpxzOov4H0AvgovwJ1iGzDLtJn/9BU+fAINfwUe6FHSLhu83viV/+/HrOePX+STT2B9uWGbrMHHLldRBlhS/CJQmcRxJFqZica01XixAZsYiH1uolZxLrR/SgxVIJjkpQP4PE9sE59LKLr7kltSBogS5tyszzH8Fvw8/AS8rNOg0xUS9fIaHwb+6et8Q/gyvKRjf5OusOzGx8evA/BP4IP11uN/grca5O0lcsPLJ5YjwI4QkJBOHa0WdMZYGxPbh2W2nR9v3WxEWqgp/G3+6VZbRLSAAZ3BhdhAaUL33VUSw9yjEsvbaQ9u4A/gGXwZXoEHOuU1GSj2chf+Mo+f8IcfcAxfIKVmyunRbYQVnoevwgfw3TXXcw++xNuP4fhyueEUNttEduRVaDttddoP0eSxLe2LENk6itYxlrxBNBYrNNKSQmeaLcm9c8UsaB5WyO6675yyQIAWSDpBVoA/gxmcwEvwoDv0m58UE7gHn+fJOa8/Ywan8EKRfjsopF83eCglX/Sfr7OeaRoQfvt1CGvIDccH5BCvw1sWIzRGC/66t0VTcLZQZtm6PlAasbOJ9iwWtUo7biktTSIPxnR24jxP1ZKaqq+2RcXM9OrBAm/AAs7hDJ5bNmGb+KIfwCs8a3jnjBrOFeMjHSCdbKr+2uOLfnOd9eiA8Hvvwwq54VbP2OqwkB48Ytc4YEOiH2vTXqodabfWEOzso4qxdbqD5L6tbtNPECqbhnA708DZH4QOJUXqScmUlks7Ot6FBuZw3n2mEbaUX7kDzxHOOQk8nKWMzAzu6ZZ8sOFw4RK+6PcuXo9tB4SbMz58ApfKDXf3szjNIIbGpD5TKTRxGkEMLjLl+K3wlWXBsCUxIDU+jbOiysESqAy1MGUJpXgwbTWzNOVEziIXZrJ+VIztl1PUBxTSo0dwn2bOmfDRPD3TRTGlfbCJvO9KvuhL1hMHhB9wPuPRLGHcdOWG2xc0U+5bQtAJT0nRTewXL1pgk2+rZAdeWmz3jxAqfNQQdzTlbF8uJ5ecEIWvTkevAHpwz7w78QujlD/Lr491bD8/1vhM2yrUQRrWXNQY4fGilfctMWYjL72UL/qS9eiA8EmN88nbNdour+PBbbAjOjIa4iBhfFg6rxeKdEGcL6p3EWR1Qq2Qkhs2DrnkRnmN9tG2EAqmgPw6hoL7Oza7B+3SCrR9tRftko+Lsf2F/mkTndN2LmzuMcKTuj/mX2+4Va3ki16+nnJY+S7MefpkidxwnV+4wkXH8TKnX0tsYzYp29DOOoSW1nf7nTh2akYiWmcJOuTidSaqESrTYpwjJJNVGQr+rLI7WsqerHW6Kp/oM2pKuV7T1QY9gjqlZp41/WfKpl56FV/0kvXQFRyeQ83xaTu5E8p5dNP3dUF34ihyI3GSpeCsywSh22ZJdWto9winhqifb7VRvgktxp13vyjrS0EjvrRfZ62uyqddSWaWYlwTPAtJZ2oZ3j/Sgi/mi+6vpzesfAcWNA0n8xVyw90GVFGuZjTXEQy+6GfLGLMLL523f5E0OmxVjDoOuRiH91RKU+vtoCtH7TgmvBLvtFXWLW15H9GTdVw8ow4IlRLeHECN9ym1e9K0I+Cbnhgv4Yu+aD2HaQJ80XDqOzSGAV4+4yCqBxrsJAX6ZTIoX36QnvzhhzzMfFW2dZVLOJfo0zbce5OvwXMFaZ81mOnlTVXpDZsQNuoYWveketKb5+6JOOsgX+NTm7H49fUTlx+WLuWL7qxnOFh4BxpmJx0p2gDzA/BUARuS6phR+pUsY7MMboAHx5xNsSVfVZcYSwqCKrqon7zM+8ecCkeS4nm3rINuaWvVNnMRI1IRpxTqx8PZUZ0Br/UEduo3B3hNvmgZfs9gQPj8vIOxd2kndir3awvJ6BLvoUuOfFWNYB0LR1OQJoUySKb9IlOBx74q1+ADC2G6rOdmFdJcD8BkfualA+BdjOOzP9uUhGUEX/TwhZsUduwRr8wNuXKurCixLBgpQI0mDbJr9dIqUuV+92ngkJZ7xduCk2yZKbfWrH1VBiTg9VdzsgRjW3CVXCvAwDd+c1z9dWw9+B+8MJL/eY15ZQ/HqvTwVdsZn5WQsgRRnMaWaecu3jFvMBEmgg+FJFZsnSl0zjB9OqPYaBD7qmoVyImFvzi41usesV0julaAR9dfR15Xzv9sEruRDyk1nb+QaLU67T885GTls6YgcY+UiMa25M/pwGrbCfzkvR3e0jjtuaFtnwuagHTSb5y7boBH119HXhvwP487jJLsLJ4XnUkHX5sLbS61dpiAXRoZSCrFJ+EjpeU3puVfitngYNo6PJrAigKktmwjyQdZpfq30mmtulaAx9Zfx15Xzv+cyeuiBFUs9zq8Kq+XB9a4PVvph3GV4E3y8HENJrN55H1X2p8VyqSKwVusJDKzXOZzplWdzBUFK9e+B4+uv468xvI/b5xtSAkBHQaPvtqWzllVvEOxPbuiE6+j2pvjcKsbvI7txnRErgfH7LdXqjq0IokKzga14GzQ23SSbCQvO6r+Or7SMIr/efOkkqSdMnj9mBx2DRsiY29Uj6+qK9ZrssCKaptR6HKURdwUYeUWA2kPzVKQO8ku2nU3Anhs/XWkBx3F/7wJtCTTTIKftthue1ty9xvNYLY/zo5KSbIuKbXpbEdSyeRyYdAIwKY2neyoc3+k1XUaufYga3T9daMUx/r8z1s10ITknIO0kuoMt+TB8jK0lpayqqjsJ2qtXAYwBU932zinimgmd6mTRDnQfr88q36NAI+tv24E8Pr8zxtasBqx0+xHH9HhlrwsxxNUfKOHQaZBITNf0uccj8GXiVmXAuPEAKSdN/4GLHhs/XWj92dN/uetNuBMnVR+XWDc25JLjo5Mg5IZIq226tmCsip2zZliL213YrTlL2hcFjpCduyim3M7/eB16q/blQsv5X/esDRbtJeabLIosWy3ycavwLhtxdWzbMmHiBTiVjJo6lCLjXZsi7p9PEPnsq6X6wd4bP11i0rD5fzPm/0A6brrIsllenZs0lCJlU4abakR59enZKrKe3BZihbTxlyZ2zl1+g0wvgmA166/bhwDrcn/7Ddz0eWZuJvfSESug6NzZsox3Z04FIxz0mUjMwVOOVTq1CQ0AhdbBGVdjG/CgsfUX7esJl3K/7ytWHRv683praW/8iDOCqWLLhpljDY1ZpzK75QiaZoOTpLKl60auHS/97oBXrv+umU9+FL+5+NtLFgjqVLCdbmj7pY5zPCPLOHNCwXGOcLquOhi8CmCWvbcuO73XmMUPab+ug3A6/A/78Bwe0bcS2+tgHn4J5pyS2WbOck0F51Vq3LcjhLvZ67p1ABbaL2H67bg78BfjKi/jr3+T/ABV3ilLmNXTI2SpvxWBtt6/Z//D0z/FXaGbSBgylzlsEGp+5//xrd4/ae4d8DUUjlslfIYS3t06HZpvfQtvv0N7AHWqtjP2pW08QD/FLy//da38vo8PNlKHf5y37Dxdfe/oj4kVIgFq3koLReSR76W/bx//n9k8jonZxzWTANVwEniDsg87sOSd/z7//PvMp3jQiptGVWFX2caezzAXwfgtzYUvbr0iozs32c3Uge7varH+CNE6cvEYmzbPZ9hMaYDdjK4V2iecf6EcEbdUDVUARda2KzO/JtCuDbNQB/iTeL0EG1JSO1jbXS+nLxtPMDPw1fh5+EPrgSEKE/8Gry5A73ui87AmxwdatyMEBCPNOCSKUeRZ2P6Myb5MRvgCHmA9ywsMifU+AYXcB6Xa5GibUC5TSyerxyh0j6QgLVpdyhfArRTTLqQjwe4HOD9s92D4Ap54odXAPBWLAwB02igG5Kkc+piN4lvODIFGAZgT+EO4Si1s7fjSR7vcQETUkRm9O+MXyo9OYhfe4xt9STQ2pcZRLayCV90b4D3jR0DYAfyxJ+eywg2IL7NTMXna7S/RpQ63JhWEM8U41ZyQGjwsVS0QBrEKLu8xwZsbi4wLcCT+OGidPIOCe1PiSc9Qt+go+vYqB7cG+B9d8cAD+WJPz0Am2gxXgU9IneOqDpAAXOsOltVuMzpdakJXrdPCzXiNVUpCeOos5cxnpQT39G+XVLhs1osQVvJKPZyNq8HDwd4d7pNDuWJPxVX7MSzqUDU6gfadKiNlUFTzLeFHHDlzO4kpa7aiKhBPGKwOqxsBAmYkOIpipyXcQSPlRTf+Tii0U3EJGaZsDER2qoB3h2hu0qe+NNwUooYU8y5mILbJe6OuX+2FTKy7bieTDAemaQyQ0CPthljSWO+xmFDIYiESjM5xKd6Ik5lvLq5GrQ3aCMLvmCA9wowLuWJb9xF59hVVP6O0CrBi3ZjZSNOvRy+I6klNVRJYRBaEzdN+imiUXQ8iVF8fsp+W4JXw7WISW7fDh7lptWkCwZ4d7QTXyBPfJMYK7SijjFppGnlIVJBJBYj7eUwtiP1IBXGI1XCsjNpbjENVpSAJ2hq2LTywEly3hUYazt31J8w2+aiLx3g3fohXixPfOMYm6zCGs9LVo9MoW3MCJE7R5u/WsOIjrqBoHUO0bJE9vxBpbhsd3+Nb4/vtPCZ4oZYCitNeYuC/8UDvDvy0qvkiW/cgqNqRyzqSZa/s0mqNGjtKOoTm14zZpUauiQgVfqtQiZjq7Q27JNaSK5ExRcrGCXO1FJYh6jR6CFqK7bZdQZ4t8g0rSlPfP1RdBtqaa9diqtzJkQ9duSryi2brQXbxDwbRUpFMBHjRj8+Nt7GDKgvph9okW7LX47gu0SpGnnFQ1S1lYldOsC7hYteR574ZuKs7Ei1lBsfdz7IZoxzzCVmmVqaSySzQbBVAWDek+N4jh9E/4VqZrJjPwiv9BC1XcvOWgO8275CVyBPvAtTVlDJfZkaZGU7NpqBogAj/xEHkeAuJihWYCxGN6e8+9JtSegFXF1TrhhLGP1fak3pebgPz192/8gB4d/6WT7+GdYnpH7hH/DJzzFiYPn/vjW0SgNpTNuPIZoAEZv8tlGw4+RLxy+ZjnKa5NdFoC7UaW0aduoYse6+bXg1DLg6UfRYwmhGEjqPvF75U558SANrElK/+MdpXvmqBpaXOa/MTZaa1DOcSiLaw9j0NNNst3c+63c7EKTpkvKHzu6bPbP0RkuHAVcbRY8ijP46MIbQeeT1mhA+5PV/inyDdQipf8LTvMXbwvoDy7IruDNVZKTfV4CTSRUYdybUCnGU7KUTDxLgCknqUm5aAW6/1p6eMsOYsphLzsHrE0Y/P5bQedx1F/4yPHnMB3/IOoTU9+BL8PhtjuFKBpZXnYNJxTuv+2XqolKR2UQgHhS5novuxVySJhBNRF3SoKK1XZbbXjVwWNyOjlqWJjrWJIy+P5bQedyldNScP+HZ61xKSK3jyrz+NiHG1hcOLL/+P+PDF2gOkekKGiNWKgJ+8Z/x8Iv4DdQHzcpZyF4v19I27w9/yPGDFQvmEpKtqv/TLiWMfn4sofMm9eAH8Ao0zzh7h4sJqYtxZd5/D7hkYPneDzl5idlzNHcIB0jVlQ+8ULzw/nc5/ojzl2juE0apD7LRnJxe04dMz2iOCFNtGFpTuXA5AhcTRo8mdN4kz30nVjEC4YTZQy4gpC7GlTlrePKhGsKKgeXpCYeO0MAd/GH7yKQUlXPLOasOH3FnSphjHuDvEu4gB8g66oNbtr6eMbFIA4fIBJkgayoXriw2XEDQPJrQeROAlY6aeYOcMf+IVYTU3XFlZufMHinGywaW3YLpObVBAsbjF4QJMsVUSayjk4voPsHJOQfPWDhCgDnmDl6XIRerD24HsGtw86RMHOLvVSHrKBdeVE26gKB5NKHzaIwLOmrqBWJYZDLhASG16c0Tn+CdRhWDgWXnqRZUTnPIHuMJTfLVpkoYy5CzylHVTGZMTwkGAo2HBlkQplrJX6U+uF1wZz2uwS1SQ12IqWaPuO4baZaEFBdukksJmkcTOm+YJSvoqPFzxFA/YUhIvWxcmSdPWTWwbAKVp6rxTtPFUZfKIwpzm4IoMfaYQLWgmlG5FME2gdBgm+J7J+rtS/XBbaVLsR7bpPQnpMFlo2doWaVceHk9+MkyguZNCJ1He+kuHTWyQAzNM5YSUg/GlTk9ZunAsg1qELVOhUSAK0LABIJHLKbqaEbHZLL1VA3VgqoiOKXYiS+HRyaEKgsfIqX64HYWbLRXy/qWoylIV9gudL1OWBNgBgTNmxA6b4txDT4gi3Ri7xFSLxtXpmmYnzAcWDZgY8d503LFogz5sbonDgkKcxGsWsE1OI+rcQtlgBBCSOKD1mtqYpIU8cTvBmAT0yZe+zUzeY92fYjTtGipXLhuR0ePoHk0ofNWBX+lo8Z7pAZDk8mEw5L7dVyZZoE/pTewbI6SNbiAL5xeygW4xPRuLCGbhcO4RIeTMFYHEJkYyEO9HmJfXMDEj/LaH781wHHZEtqSQ/69UnGpzH7LKIAZEDSPJnTesJTUa+rwTepI9dLJEawYV+ZkRn9g+QirD8vF8Mq0jFQ29js6kCS3E1+jZIhgPNanHdHFqFvPJLHqFwQqbIA4jhDxcNsOCCQLDomaL/dr5lyJaJU6FxPFjO3JOh3kVMcROo8u+C+jo05GjMF3P3/FuDLn5x2M04xXULPwaS6hBYki+MrMdZJSgPHlcB7nCR5bJ9Kr5ACUn9jk5kivdd8tk95SOGrtqu9lr2IhK65ZtEl7ZKrp7DrqwZfRUSN1el7+7NJxZbywOC8neNKTch5vsTEMNsoCCqHBCqIPRjIPkm0BjvFODGtto99rCl+d3wmHkW0FPdpZtC7MMcVtGFQjJLX5bdQ2+x9ypdc313uj8xlsrfuLgWXz1cRhZvJYX0iNVBRcVcmCXZs6aEf3RQF2WI/TcCbKmGU3IOoDJGDdDub0+hYckt6PlGu2BcxmhbTdj/klhccLGJMcqRjMJP1jW2ETqLSWJ/29MAoORluJ+6LPffBZbi5gqi5h6catQpmOT7/OFf5UorRpLzCqcMltBLhwd1are3kztrSzXO0LUbXRQcdLh/RdSZ+swRm819REDrtqzC4es6Gw4JCKlSnjYVpo0xeq33PrADbFLL3RuCmObVmPN+24kfa+AojDuM4umKe2QwCf6EN906HwjujaitDs5o0s1y+k3lgbT2W2i7FJdnwbLXhJUBq/9liTctSmFC/0OqUinb0QddTWamtjbHRFuWJJ6NpqZ8vO3fZJ37Db+2GkaPYLGHs7XTTdiFQJ68SkVJFVmY6McR5UycflNCsccHFaV9FNbR4NttLxw4pQ7wJd066Z0ohVbzihaxHVExd/ay04oxUKWt+AsdiQ9OUyZ2krzN19IZIwafSTFgIBnMV73ADj7V/K8u1MaY2sJp2HWm0f41tqwajEvdHWOJs510MaAqN4aoSiPCXtN2KSi46dUxHdaMquar82O1x5jqhDGvqmoE9LfxcY3zqA7/x3HA67r9ZG4O6Cuxu12/+TP+eLP+I+HErqDDCDVmBDO4larujNe7x8om2rMug0MX0rL1+IWwdwfR+p1TNTyNmVJ85ljWzbWuGv8/C7HD/izjkHNZNYlhZcUOKVzKFUxsxxN/kax+8zPWPSFKw80rJr9Tizyj3o1gEsdwgWGoxPezDdZ1TSENE1dLdNvuKL+I84nxKesZgxXVA1VA1OcL49dFlpFV5yJMhzyCmNQ+a4BqusPJ2bB+xo8V9u3x48VVIEPS/mc3DvAbXyoYr6VgDfh5do5hhHOCXMqBZUPhWYbWZECwVJljLgMUWOCB4MUuMaxGNUQDVI50TQ+S3kFgIcu2qKkNSHVoM0SHsgoZxP2d5HH8B9woOk4x5bPkKtAHucZsdykjxuIpbUrSILgrT8G7G5oCW+K0990o7E3T6AdW4TilH5kDjds+H64kS0mz24grtwlzDHBJqI8YJQExotPvoC4JBq0lEjjQkyBZ8oH2LnRsQ4Hu1QsgDTJbO8fQDnllitkxuVskoiKbRF9VwzMDvxHAdwB7mD9yCplhHFEyUWHx3WtwCbSMMTCUCcEmSGlg4gTXkHpZXWQ7kpznK3EmCHiXInqndkQjunG5kxTKEeGye7jWz9cyMR2mGiFQ15ENRBTbCp+Gh86vAyASdgmJq2MC6hoADQ3GosP0QHbnMHjyBQvQqfhy/BUbeHd5WY/G/9LK/8Ka8Jd7UFeNWEZvzPb458Dn8DGLOe3/wGL/4xP+HXlRt+M1PE2iLhR8t+lfgxsuh7AfO2AOf+owWhSZRYQbd622hbpKWKuU+XuvNzP0OseRDa+mObgDHJUSc/pKx31QdKffQ5OIJpt8GWjlgTwMc/w5MPCR/yl1XC2a2Yut54SvOtMev55Of45BOat9aWG27p2ZVORRvnEk1hqWMVUmqa7S2YtvlIpspuF1pt0syuZS2NV14mUidCSfzQzg+KqvIYCMljIx2YK2AO34fX4GWdu5xcIAb8MzTw+j/lyWM+Dw/gjs4GD6ehNgA48kX/AI7XXM/XAN4WHr+9ntywqoCakCqmKP0rmQrJJEErG2Upg1JObr01lKQy4jskWalKYfJ/EDLMpjNSHFEUAde2fltaDgmrNaWQ9+AAb8I5vKjz3L1n1LriB/BXkG/wwR9y/oRX4LlioHA4LzP2inzRx/DWmutRweFjeP3tNeSGlaE1Fde0OS11yOpmbIp2u/jF1n2RRZviJM0yBT3IZl2HWImKjQOxIyeU325b/qWyU9Moj1o07tS0G7qJDoGHg5m8yeCxMoEH8GU45tnrNM84D2l297DQ9t1YP7jki/7RmutRweEA77/HWXOh3HCxkRgldDQkAjNTMl2Iloc1qN5JfJeeTlyTRzxURTdn1Ixv2uKjs12AbdEWlBtmVdk2k7FFwj07PCZ9XAwW3dG+8xKzNFr4EnwBZpy9Qzhh3jDXebBpYcpuo4fQ44u+fD1dweEnHzI7v0xuuOALRUV8rXpFyfSTQYkhd7IHm07jpyhlkCmI0ALYqPTpUxXS+z4jgDj1Pflvmz5ecuItpIBxyTHpSTGWd9g1ApfD/bvwUhL4nT1EzqgX7cxfCcNmb3mPL/qi9SwTHJ49oj5ZLjccbTG3pRmlYi6JCG0mQrAt1+i2UXTZ2dv9IlQpN5naMYtviaXlTrFpoMsl3bOAFEa8sqPj2WCMrx3Yjx99qFwO59Aw/wgx+HlqNz8oZvA3exRDvuhL1jMQHPaOJ0+XyA3fp1OfM3qObEVdhxjvynxNMXQV4+GJyvOEFqeQBaIbbO7i63rpxCltdZShPFxkjM2FPVkn3TG+Rp9pO3l2RzFegGfxGDHIAh8SteR0C4HopXzRF61nheDw6TFN05Ebvq8M3VKKpGjjO6r7nhudTEGMtYM92HTDaR1FDMXJ1eThsbKfywyoWwrzRSXkc51flG3vIid62h29bIcFbTGhfV+faaB+ohj7dPN0C2e2lC96+XouFByen9AsunLDJZ9z7NExiUc0OuoYW6UZkIyx2YUR2z6/TiRjyKMx5GbbjLHvHuf7YmtKghf34LJfx63Yg8vrvN2zC7lY0x0tvKezo4HmGYDU+Gab6dFL+KI761lDcNifcjLrrr9LWZJctG1FfU1uwhoQE22ObjdfkSzY63CbU5hzs21WeTddH2BaL11Gi7lVdlxP1nkxqhnKhVY6knS3EPgVGg1JpN5cP/hivujOelhXcPj8HC/LyI6MkteVjlolBdMmF3a3DbsuAYhL44dxzthWSN065xxUd55Lmf0wRbOYOqH09/o9WbO2VtFdaMb4qBgtFJoT1SqoN8wPXMoXLb3p1PUEhxfnnLzGzBI0Ku7FxrKsNJj/8bn/H8fPIVOd3rfrklUB/DOeO+nkghgSPzrlPxluCMtOnDL4Yml6dK1r3vsgMxgtPOrMFUZbEUbTdIzii5beq72G4PD0DKnwjmBULUVFmy8t+k7fZ3pKc0Q4UC6jpVRqS9Umv8bxw35flZVOU1X7qkjnhZlsMbk24qQ6Hz7QcuL6sDC0iHHki96Uh2UdvmgZnjIvExy2TeJdMDZNSbdZyAHe/Yd1xsQhHiKzjh7GxQ4yqMPaywPkjMamvqrYpmO7Knad+ZQC5msCuAPWUoxrxVhrGv7a+KLXFhyONdTMrZ7ke23qiO40ZJUyzgYyX5XyL0mV7NiUzEs9mjtbMN0dERqwyAJpigad0B3/zRV7s4PIfXSu6YV/MK7+OrYe/JvfGMn/PHJe2fyUdtnFrKRNpXV0Y2559aWPt/G4BlvjTMtXlVIWCnNyA3YQBDmYIodFz41PvXPSa6rq9lWZawZ4dP115HXV/M/tnFkkrBOdzg6aP4pID+MZnTJ1SuuB6iZlyiox4HT2y3YBtkUKWooacBQUDTpjwaDt5poBHl1/HXltwP887lKKXxNUEyPqpGTyA699UqY/lt9yGdlUKra0fFWS+36iylVWrAyd7Uw0CZM0z7xKTOduznLIjG2Hx8cDPLb+OvK6Bv7n1DYci4CxUuRxrjBc0bb4vD3rN5Zz36ntLb83eVJIB8LiIzCmn6SMPjlX+yNlTjvIGjs+QzHPf60Aj62/jrzG8j9vYMFtm1VoRWCJdmw7z9N0t+c8cxZpPeK4aTRicS25QhrVtUp7U578chk4q04Wx4YoQSjFryUlpcQ1AbxZ/XVMknIU//OGl7Q6z9Zpxi0+3yFhSkjUDpnCIUhLWVX23KQ+L9vKvFKI0ZWFQgkDLvBoylrHNVmaw10zwCPrr5tlodfnf94EWnQ0lFRWy8pW9LbkLsyUVDc2NSTHGDtnD1uMtchjbCeb1mpxFP0YbcClhzdLu6lfO8Bj6q+bdT2sz/+8SZCV7VIxtt0DUn9L7r4cLYWDSXnseEpOGFuty0qbOVlS7NNzs5FOGJUqQpl2Q64/yBpZf90sxbE+//PGdZ02HSipCbmD6NItmQ4Lk5XUrGpDMkhbMm2ZVheNYV+VbUWTcv99+2NyX1VoafSuC+AN6q9bFIMv5X/eagNWXZxEa9JjlMwNWb00akGUkSoepp1/yRuuqHGbUn3UdBSTxBU6SEVklzWRUkPndVvw2PrrpjvxOvzPmwHc0hpmq82npi7GRro8dXp0KXnUQmhZbRL7NEVp1uuZmO45vuzKsHrktS3GLWXODVjw+vXXLYx4Hf7njRPd0i3aoAGX6W29GnaV5YdyDj9TFkakje7GHYzDoObfddHtOSpoi2SmzJHrB3hM/XUDDEbxP2/oosszcRlehWXUvzHv4TpBVktHqwenFo8uLVmy4DKLa5d3RtLrmrM3aMFr1183E4sewf+85VWeg1c5ag276NZrM9IJVNcmLEvDNaV62aq+14IAOGFsBt973Ra8Xv11YzXwNfmft7Jg2oS+XOyoC8/cwzi66Dhmgk38kUmP1CUiYWOX1bpD2zWXt2FCp7uq8703APAa9dfNdscR/M/bZLIyouVxqJfeWvG9Je+JVckHQ9+CI9NWxz+blX/KYYvO5n2tAP/vrlZ7+8/h9y+9qeB/Hnt967e5mevX10rALDWK//FaAT5MXdBXdP0C/BAes792c40H+AiAp1e1oH8HgH94g/Lttx1gp63op1eyoM/Bvw5/G/7xFbqJPcCXnmBiwDPb/YKO4FX4OjyCb289db2/Noqicw4i7N6TVtoz8tNwDH+8x/i6Ae7lmaQVENzJFb3Di/BFeAwz+Is9SjeQySpPqbLFlNmyz47z5a/AF+AYFvDmHqibSXTEzoT4Gc3OALaqAP4KPFUJ6n+1x+rGAM6Zd78bgJ0a8QN4GU614vxwD9e1Amy6CcskNrczLx1JIp6HE5UZD/DBHrFr2oNlgG4Odv226BodoryjGJ9q2T/AR3vQrsOCS0ctXZi3ruLlhpFDJYl4HmYtjQCP9rhdn4suySLKDt6wLcC52h8xPlcjju1fn+yhuw4LZsAGUuo2b4Fx2UwQu77uqRHXGtg92aN3tQCbFexc0uk93vhTXbct6y7MulLycoUljx8ngDMBg1tvJjAazpEmOtxlzclvj1vQf1Tx7QlPDpGpqgtdSKz/d9/hdy1vTfFHSmC9dGDZbLiezz7Ac801HirGZsWjydfZyPvHXL/Y8Mjzg8BxTZiuwKz4Eb8sBE9zznszmjvFwHKPIWUnwhqfVRcd4Ck0K6ate48m1oOfrX3/yOtvAsJ8zsPAM89sjnddmuLuDPjX9Bu/L7x7xpMzFk6nWtyQfPg278Gn4Aekz2ZgOmU9eJ37R14vwE/BL8G3aibCiWMWWDQ0ZtkPMnlcGeAu/Ag+8ZyecU5BPuy2ILD+sQqyZhAKmn7XZd+jIMTN9eBL7x95xVLSX4On8EcNlXDqmBlqS13jG4LpmGbkF/0CnOi3H8ETOIXzmnmtb0a16Tzxj1sUvQCBiXZGDtmB3KAefPH94xcUa/6vwRn80GOFyjEXFpba4A1e8KQfFF+259tx5XS4egYn8fQsLGrqGrHbztr+uByTahWuL1NUGbDpsnrwBfePPwHHIf9X4RnM4Z2ABWdxUBlqQ2PwhuDxoS0vvqB1JzS0P4h2nA/QgTrsJFn+Y3AOjs9JFC07CGWX1oNX3T/yHOzgDjwPn1PM3g9Jk9lZrMEpxnlPmBbjyo2+KFXRU52TJM/2ALcY57RUzjObbjqxVw++4P6RAOf58pcVsw9Daje3htriYrpDOonre3CudSe6bfkTEgHBHuDiyu5MCsc7BHhYDx7ePxLjqigXZsw+ijMHFhuwBmtoTPtOxOrTvYJDnC75dnUbhfwu/ZW9AgYd+peL68HD+0emKquiXHhWjJg/UrkJYzuiaL3E9aI/ytrCvAd4GcYZMCkSQxfUg3v3j8c4e90j5ZTPdvmJJGHnOCI2nHS8081X013pHuBlV1gB2MX1YNmWLHqqGN/TWmG0y6clJWthxNUl48q38Bi8vtMKyzzpFdSDhxZ5WBA5ZLt8Jv3895DduBlgbPYAj8C4B8hO68FDkoh5lydC4FiWvBOVqjYdqjiLv92t8yPDjrDaiHdUD15qkSURSGmXJwOMSxWAXYwr3zaAufJ66l+94vv3AO+vPcD7aw/w/toDvL/2AO+vPcD7aw/wHuD9tQd4f+0B3l97gPfXHuD9tQd4f+0B3l97gG8LwP8G/AL8O/A5OCq0Ys2KIdv/qOIXG/4mvFAMF16gZD+2Xvu/B8as5+8bfllWyg0zaNO5bfXj6vfhhwD86/Aq3NfRS9t9WPnhfnvCIw/CT8GLcFTMnpntdF/z9V+PWc/vWoIH+FL3Znv57PitcdGP4R/C34avw5fgRVUInCwbsn1yyA8C8zm/BH8NXoXnVE6wVPjdeCI38kX/3+Ct9dbz1pTmHFRu+Hm4O9Ch3clr99negxfwj+ER/DR8EV6B5+DuQOnTgUw5rnkY+FbNU3gNXh0o/JYTuWOvyBf9FvzX663HH/HejO8LwAl8Hl5YLTd8q7sqA3wbjuExfAFegQdwfyDoSkWY8swzEf6o4Qyewefg+cHNbqMQruSL/u/WWc+E5g7vnnEXgDmcDeSGb/F4cBcCgT+GGRzDU3hZYburAt9TEtHgbM6JoxJ+6NMzzTcf6c2bycv2+KK/f+l6LBzw5IwfqZJhA3M472pWT/ajKxnjv4AFnMEpnBTPND6s2J7qHbPAqcMK74T2mZ4VGB9uJA465It+/eL1WKhYOD7xHOkr1ajK7d0C4+ke4Hy9qXZwpgLr+Znm/uNFw8xQOSy8H9IzjUrd9+BIfenYaylf9FsXr8fBAadnPIEDna8IBcwlxnuA0/Wv6GAWPd7dDIKjMdSWueAsBj4M7TOd06qBbwDwKr7oleuxMOEcTuEZTHWvDYUO7aHqAe0Bbq+HEFRzOz7WVoTDQkVds7A4sIIxfCQdCefFRoIOF/NFL1mPab/nvOakSL/Q1aFtNpUb/nFOVX6gzyg/1nISyDfUhsokIzaBR9Kxm80s5mK+6P56il1jXic7nhQxsxSm3OwBHl4fFdLqi64nDQZvqE2at7cWAp/IVvrN6/BFL1mPhYrGMBfOi4PyjuSGf6wBBh7p/FZTghCNWGgMzlBbrNJoPJX2mW5mwZfyRffXo7OFi5pZcS4qZUrlViptrXtw+GQoyhDPS+ANjcGBNRiLCQDPZPMHuiZfdFpPSTcQwwKYdRNqpkjm7AFeeT0pJzALgo7g8YYGrMHS0iocy+YTm2vyRUvvpXCIpQ5pe666TJrcygnScUf/p0NDs/iAI/nqDHC8TmQT8x3NF91l76oDdQGwu61Z6E0ABv7uO1dbf/37Zlv+Zw/Pbh8f1s4Avur6657/+YYBvur6657/+YYBvur6657/+YYBvur6657/+aYBvuL6657/+VMA8FXWX/f8zzcN8BXXX/f8zzcNMFdbf93zP38KLPiK6697/uebtuArrr/u+Z9vGmCusP6653/+1FjwVdZf9/zPN7oHX339dc//fNMu+irrr3v+50+Bi+Zq6697/uebA/jz8Pudf9ht/fWv517J/XUzAP8C/BAeX9WCDrUpZ3/dEMBxgPcfbtTVvsYV5Yn32u03B3Ac4P3b8I+vxNBKeeL9dRMAlwO83959qGO78sT769oB7g3w/vGVYFzKE++v6wV4OMD7F7tckFkmT7y/rhHgpQO8b+4Y46XyxPvrugBeNcB7BRiX8sT767oAvmCA9woAHsoT76+rBJjLBnh3txOvkifeX1dswZcO8G6N7sXyxPvr6i340gHe3TnqVfLE++uKAb50gHcXLnrX8sR7gNdPRqwzwLu7Y/FO5Yn3AK9jXCMGeHdgxDuVJ75VAI8ljP7PAb3/RfjcZfePHBB+79dpfpH1CanN30d+mT1h9GqAxxJGM5LQeeQ1+Tb+EQJrElLb38VHQ94TRq900aMIo8cSOo+8Dp8QfsB8zpqE1NO3OI9Zrj1h9EV78PqE0WMJnUdeU6E+Jjyk/hbrEFIfeWbvId8H9oTRFwdZaxJGvziW0Hn0gqYB/wyZ0PwRlxJST+BOw9m77Amj14ii1yGM/txYQudN0qDzGe4EqfA/5GJCagsHcPaEPWH0esekSwmjRxM6b5JEcZ4ww50ilvAOFxBSx4yLW+A/YU8YvfY5+ALC6NGEzhtmyZoFZoarwBLeZxUhtY4rc3bKnjB6TKJjFUHzJoTOozF2YBpsjcyxDgzhQ1YRUse8+J4wenwmaylB82hC5w0zoRXUNXaRBmSMQUqiWSWkLsaVqc/ZE0aPTFUuJWgeTei8SfLZQeMxNaZSIzbII4aE1Nmr13P2hNHjc9E9guYNCZ032YlNwESMLcZiLQHkE4aE1BFg0yAR4z1h9AiAGRA0jyZ03tyIxWMajMPWBIsxYJCnlITU5ShiHYdZ94TR4wCmSxg9jtB5KyPGYzymAYexWEMwAPIsAdYdV6aObmNPGD0aYLoEzaMJnTc0Ygs+YDw0GAtqxBjkuP38bMRWCHn73xNGjz75P73WenCEJnhwyVe3AEe8TtKdJcYhBl97wuhNAObK66lvD/9J9NS75v17wuitAN5fe4D31x7g/bUHeH/tAd5fe4D3AO+vPcD7aw/w/toDvL/2AO+vPcD7aw/w/toDvAd4f/24ABzZ8o+KLsSLS+Pv/TqTb3P4hKlQrTGh+fbIBT0Axqznnb+L/V2mb3HkN5Mb/nEHeK7d4IcDld6lmDW/iH9E+AH1MdOw/Jlu2T1xNmY98sv4wHnD7D3uNHu54WUuOsBTbQuvBsPT/UfzNxGYzwkP8c+Yz3C+r/i6DcyRL/rZ+utRwWH5PmfvcvYEt9jLDS/bg0/B64DWKrQM8AL8FPwS9beQCe6EMKNZYJol37jBMy35otdaz0Bw2H/C2Smc7+WGB0HWDELBmOByA3r5QONo4V+DpzR/hFS4U8wMW1PXNB4TOqYz9urxRV++ntWCw/U59Ty9ebdWbrgfRS9AYKKN63ZokZVygr8GZ/gfIhZXIXPsAlNjPOLBby5c1eOLvmQ9lwkOy5x6QV1j5TYqpS05JtUgUHUp5toHGsVfn4NX4RnMCe+AxTpwmApTYxqMxwfCeJGjpXzRF61nbcHhUBPqWze9svwcHJ+S6NPscKrEjug78Dx8Lj3T8D4YxGIdxmJcwhi34fzZUr7olevZCw5vkOhoClq5zBPZAnygD/Tl9EzDh6kl3VhsHYcDEb+hCtJSvuiV69kLDm+WycrOTArHmB5/VYyP6jOVjwgGawk2zQOaTcc1L+aLXrKeveDwZqlKrw8U9Y1p66uK8dEzdYwBeUQAY7DbyYNezBfdWQ97weEtAKYQg2xJIkuveAT3dYeLGH+ShrWNwZgN0b2YL7qznr3g8JYAo5bQBziPjx7BPZ0d9RCQp4UZbnFdzBddor4XHN4KYMrB2qHFRIzzcLAHQZ5the5ovui94PCWAPefaYnxIdzRwdHCbuR4B+tbiy96Lzi8E4D7z7S0mEPd+eqO3cT53Z0Y8SV80XvB4Z0ADJi/f7X113f+7p7/+UYBvur6657/+YYBvur6657/+aYBvuL6657/+aYBvuL6657/+aYBvuL6657/+aYBvuL6657/+VMA8FXWX/f8z58OgK+y/rrnf75RgLna+uue//lTA/CV1V/3/M837aKvvv6653++UQvmauuve/7nTwfAV1N/3fM/fzr24Cuuv+75nz8FFnxl9dc9//MOr/8/glixwRuUfM4AAAAASUVORK5CYII=",f.tArea,o),Object(b.d)("data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAEIAAAAhCAAAAABIXyLAAAAAOElEQVRIx2NgGAWjYBSMglEwEICREYRgFBZBqDCSLA2MGPUIVQETE9iNUAqLR5gIeoQKRgwXjwAAGn4AtaFeYLEAAAAASUVORK5CYII=",f.tSearch,d);var p=Object(n.__assign)({},C),m=Object(u.a)(e,"triangles",j,p,f);return Object(c.a)(m,f)}(e,this.edgesTarget.texture),this.blendRenderable=function(e,t,r){var a=t.getWidth(),o=t.getHeight(),d=Object(n.__assign)(Object(n.__assign)({},i.c),{tColor:s.e.create(t),tWeights:s.e.create(r),uTexSizeInv:s.e.create(l.Vec2.create(1/a,1/o)),uViewport:s.e.create(Object(l.Vec4)())}),f=Object(n.__assign)({},P),p=Object(u.a)(e,"triangles",E,f,d);return Object(c.a)(p,d)}(e,t,this.weightsTarget.texture),this._supported=!0}else _.a&&console.log('Missing "HTMLImageElement" required for "SMAA"')}return Object.defineProperty(e.prototype,"supported",{get:function(){return this._supported},enumerable:!1,configurable:!0}),e.prototype.updateState=function(e){var t=this.webgl,r=t.gl,n=t.state;n.enable(r.SCISSOR_TEST),n.disable(r.BLEND),n.disable(r.DEPTH_TEST),n.depthMask(!1);var i=e.x,a=e.y,o=e.width,u=e.height;r.viewport(i,a,o,u),r.scissor(i,a,o,u),n.clearColor(0,0,0,1),r.clear(r.COLOR_BUFFER_BIT),s.e.update(this.edgesRenderable.values.uViewport,y.a.toVec4(this.edgesRenderable.values.uViewport.ref.value,e)),s.e.update(this.weightsRenderable.values.uViewport,y.a.toVec4(this.weightsRenderable.values.uViewport.ref.value,e)),s.e.update(this.blendRenderable.values.uViewport,y.a.toVec4(this.blendRenderable.values.uViewport.ref.value,e))},e.prototype.setSize=function(e,t){var r=this.edgesTarget.getWidth(),n=this.edgesTarget.getHeight();e===r&&t===n||(this.edgesTarget.setSize(e,t),this.weightsTarget.setSize(e,t),s.e.update(this.edgesRenderable.values.uTexSizeInv,l.Vec2.set(this.edgesRenderable.values.uTexSizeInv.ref.value,1/e,1/t)),s.e.update(this.weightsRenderable.values.uTexSizeInv,l.Vec2.set(this.weightsRenderable.values.uTexSizeInv.ref.value,1/e,1/t)),s.e.update(this.blendRenderable.values.uTexSizeInv,l.Vec2.set(this.blendRenderable.values.uTexSizeInv.ref.value,1/e,1/t)))},e.prototype.update=function(e,t){var r=!1;this.edgesRenderable.values.tColor.ref.value!==e&&(s.e.update(this.edgesRenderable.values.tColor,e),r=!0),this.edgesRenderable.values.dEdgeThreshold.ref.value!==t.edgeThreshold&&(s.e.update(this.edgesRenderable.values.dEdgeThreshold,t.edgeThreshold),r=!0),r&&this.edgesRenderable.update(),this.weightsRenderable.values.dMaxSearchSteps.ref.value!==t.maxSearchSteps&&(s.e.update(this.weightsRenderable.values.dMaxSearchSteps,t.maxSearchSteps),this.weightsRenderable.update()),this.blendRenderable.values.tColor.ref.value!==e&&(s.e.update(this.blendRenderable.values.tColor,e),this.blendRenderable.update())},e.prototype.render=function(e,t){this.edgesTarget.bind(),this.updateState(e),this.edgesRenderable.render(),this.weightsTarget.bind(),this.updateState(e),this.weightsRenderable.render(),t?t.bind():this.webgl.unbindFramebuffer(),this.updateState(e),this.blendRenderable.render()},e}(),O=Object(n.__assign)(Object(n.__assign)({},i.b),{tColor:Object(a.i)("texture","rgba","ubyte","linear"),uTexSizeInv:Object(a.j)("v2"),uViewport:Object(a.j)("v4"),dEdgeThreshold:Object(a.c)("number")}),w=Object(o.g)("smaa-edges","\nprecision highp float;\n\nattribute vec2 aPosition;\nuniform vec2 uQuadScale;\n\nuniform vec2 uTexSizeInv;\nuniform vec4 uViewport;\n\nvarying vec2 vUv;\nvarying vec4 vOffset[3];\n\nvoid SMAAEdgeDetectionVS(vec2 texCoord) {\n    vOffset[0] = texCoord.xyxy + uTexSizeInv.xyxy * vec4(-1.0, 0.0, 0.0, 1.0); // WebGL port note: Changed sign in W component\n    vOffset[1] = texCoord.xyxy + uTexSizeInv.xyxy * vec4(1.0, 0.0, 0.0, -1.0); // WebGL port note: Changed sign in W component\n    vOffset[2] = texCoord.xyxy + uTexSizeInv.xyxy * vec4(-2.0, 0.0, 0.0, 2.0); // WebGL port note: Changed sign in W component\n}\n\nvoid main() {\n    vec2 scale = uViewport.zw * uTexSizeInv;\n    vec2 shift = uViewport.xy * uTexSizeInv;\n    vUv = (aPosition + 1.0) * 0.5 * scale + shift;\n    SMAAEdgeDetectionVS(vUv);\n    vec2 position = aPosition * uQuadScale - vec2(1.0, 1.0) + uQuadScale;\n    gl_Position = vec4(position, 0.0, 1.0);\n}\n","\nprecision highp float;\nprecision highp int;\nprecision highp sampler2D;\n\nuniform sampler2D tColor;\nuniform vec2 uTexSizeInv;\n\nvarying vec2 vUv;\nvarying vec4 vOffset[3];\n\nvec4 SMAAColorEdgeDetectionPS(vec2 texcoord, vec4 offset[3], sampler2D colorTex) {\n    vec2 threshold = vec2(dEdgeThreshold, dEdgeThreshold);\n\n    // Calculate color deltas:\n    vec4 delta;\n    vec3 C = texture2D(colorTex, texcoord).rgb;\n\n    vec3 Cleft = texture2D(colorTex, offset[0].xy).rgb;\n    vec3 t = abs(C - Cleft);\n    delta.x = max(max(t.r, t.g), t.b);\n\n    vec3 Ctop = texture2D(colorTex, offset[0].zw).rgb;\n    t = abs(C - Ctop);\n    delta.y = max(max(t.r, t.g), t.b);\n\n    // We do the usual threshold:\n    vec2 edges = step(threshold, delta.xy);\n\n    // Then discard if there is no edge:\n    if (dot(edges, vec2(1.0, 1.0 )) == 0.0)\n        discard;\n\n    // Calculate right and bottom deltas:\n    vec3 Cright = texture2D(colorTex, offset[1].xy).rgb;\n    t = abs( C - Cright );\n    delta.z = max(max(t.r, t.g), t.b);\n\n    vec3 Cbottom  = texture2D(colorTex, offset[1].zw).rgb;\n    t = abs(C - Cbottom);\n    delta.w = max(max(t.r, t.g), t.b);\n\n    // Calculate the maximum delta in the direct neighborhood:\n    float maxDelta = max(max(max(delta.x, delta.y), delta.z), delta.w );\n\n    // Calculate left-left and top-top deltas:\n    vec3 Cleftleft  = texture2D(colorTex, offset[2].xy).rgb;\n    t = abs( C - Cleftleft );\n    delta.z = max(max(t.r, t.g), t.b);\n\n    vec3 Ctoptop = texture2D(colorTex, offset[2].zw).rgb;\n    t = abs(C - Ctoptop);\n    delta.w = max(max(t.r, t.g), t.b);\n\n    // Calculate the final maximum delta:\n    maxDelta = max(max(maxDelta, delta.z), delta.w);\n\n    // Local contrast adaptation in action:\n    edges.xy *= step(0.5 * maxDelta, delta.xy);\n\n    return vec4(edges, 0.0, 0.0);\n}\n\nvoid main() {\n    gl_FragColor = SMAAColorEdgeDetectionPS(vUv, vOffset, tColor);\n}\n");var C=Object(n.__assign)(Object(n.__assign)({},i.b),{tEdges:Object(a.i)("texture","rgba","ubyte","linear"),tArea:Object(a.i)("texture","rgb","ubyte","linear"),tSearch:Object(a.i)("texture","rgba","ubyte","nearest"),uTexSizeInv:Object(a.j)("v2"),uViewport:Object(a.j)("v4"),dMaxSearchSteps:Object(a.c)("number")}),j=Object(o.g)("smaa-weights","\nprecision highp float;\n\nattribute vec2 aPosition;\nuniform vec2 uQuadScale;\n\nuniform vec2 uTexSizeInv;\nuniform vec4 uViewport;\n\nvarying vec2 vUv;\nvarying vec4 vOffset[3];\nvarying vec2 vPixCoord;\n\nvoid SMAABlendingWeightCalculationVS(vec2 texCoord) {\n    vPixCoord = texCoord / uTexSizeInv;\n\n    // We will use these offsets for the searches later on (see @PSEUDO_GATHER4):\n    vOffset[0] = texCoord.xyxy + uTexSizeInv.xyxy * vec4(-0.25, 0.125, 1.25, 0.125); // WebGL port note: Changed sign in Y and W components\n    vOffset[1] = texCoord.xyxy + uTexSizeInv.xyxy * vec4(-0.125, 0.25, -0.125, -1.25); // WebGL port note: Changed sign in Y and W components\n\n    // And these for the searches, they indicate the ends of the loops:\n    vOffset[2] = vec4(vOffset[0].xz, vOffset[1].yw) + vec4(-2.0, 2.0, -2.0, 2.0) * uTexSizeInv.xxyy * float(dMaxSearchSteps);\n}\n\nvoid main() {\n    vec2 scale = uViewport.zw * uTexSizeInv;\n    vec2 shift = uViewport.xy * uTexSizeInv;\n    vUv = (aPosition + 1.0) * 0.5 * scale + shift;\n    SMAABlendingWeightCalculationVS(vUv);\n    vec2 position = aPosition * uQuadScale - vec2(1.0, 1.0) + uQuadScale;\n    gl_Position = vec4(position, 0.0, 1.0);\n}\n","\nprecision highp float;\nprecision highp int;\nprecision highp sampler2D;\n\n#define SMAASampleLevelZeroOffset(tex, coord, offset) texture2D(tex, coord + float(offset) * uTexSizeInv, 0.0)\n\n#define SMAA_AREATEX_MAX_DISTANCE 16\n#define SMAA_AREATEX_PIXEL_SIZE (1.0 / vec2(160.0, 560.0))\n#define SMAA_AREATEX_SUBTEX_SIZE (1.0 / 7.0)\n\nuniform sampler2D tEdges;\nuniform sampler2D tArea;\nuniform sampler2D tSearch;\nuniform vec2 uTexSizeInv;\n\nvarying vec2 vUv;\nvarying vec4 vOffset[3];\nvarying vec2 vPixCoord;\n\n#if __VERSION__ == 100\n    vec2 round(vec2 x) {\n        return sign(x) * floor(abs(x) + 0.5);\n    }\n#endif\n\nfloat SMAASearchLength(sampler2D searchTex, vec2 e, float bias, float scale) {\n    // Not required if searchTex accesses are set to point:\n    // float2 SEARCH_TEX_PIXEL_SIZE = 1.0 / float2(66.0, 33.0);\n    // e = float2(bias, 0.0) + 0.5 * SEARCH_TEX_PIXEL_SIZE +\n    //     e * float2(scale, 1.0) * float2(64.0, 32.0) * SEARCH_TEX_PIXEL_SIZE;\n    e.r = bias + e.r * scale;\n    return 255.0 * texture2D(searchTex, e, 0.0).r;\n}\n\nfloat SMAASearchXLeft(sampler2D edgesTex, sampler2D searchTex, vec2 texCoord, float end) {\n    /**\n     * @PSEUDO_GATHER4\n     * This texCoord has been offset by (-0.25, -0.125) in the vertex shader to\n     * sample between edge, thus fetching four edges in a row.\n     * Sampling with different offsets in each direction allows to disambiguate\n     * which edges are active from the four fetched ones.\n     */\n    vec2 e = vec2(0.0, 1.0);\n\n    for (int i = 0; i < dMaxSearchSteps; i++) { // WebGL port note: Changed while to for\n        e = texture2D( edgesTex, texCoord, 0.0).rg;\n        texCoord -= vec2(2.0, 0.0) * uTexSizeInv;\n        if (!(texCoord.x > end && e.g > 0.8281 && e.r == 0.0)) break;\n    }\n\n    // We correct the previous (-0.25, -0.125) offset we applied:\n    texCoord.x += 0.25 * uTexSizeInv.x;\n\n    // The searches are bias by 1, so adjust the coords accordingly:\n    texCoord.x += uTexSizeInv.x;\n\n    // Disambiguate the length added by the last step:\n    texCoord.x += 2.0 * uTexSizeInv.x; // Undo last step\n    texCoord.x -= uTexSizeInv.x * SMAASearchLength(searchTex, e, 0.0, 0.5);\n\n    return texCoord.x;\n}\n\nfloat SMAASearchXRight(sampler2D edgesTex, sampler2D searchTex, vec2 texCoord, float end) {\n    vec2 e = vec2( 0.0, 1.0 );\n\n    for (int i = 0; i < dMaxSearchSteps; i++) { // WebGL port note: Changed while to for\n        e = texture2D(edgesTex, texCoord, 0.0).rg;\n        texCoord += vec2(2.0, 0.0) * uTexSizeInv;\n        if (!(texCoord.x < end && e.g > 0.8281 && e.r == 0.0)) break;\n    }\n\n    texCoord.x -= 0.25 * uTexSizeInv.x;\n    texCoord.x -= uTexSizeInv.x;\n    texCoord.x -= 2.0 * uTexSizeInv.x;\n    texCoord.x += uTexSizeInv.x * SMAASearchLength( searchTex, e, 0.5, 0.5 );\n\n    return texCoord.x;\n}\n\nfloat SMAASearchYUp(sampler2D edgesTex, sampler2D searchTex, vec2 texCoord, float end) {\n    vec2 e = vec2( 1.0, 0.0 );\n\n    for (int i = 0; i < dMaxSearchSteps; i++) { // WebGL port note: Changed while to for\n        e = texture2D(edgesTex, texCoord, 0.0).rg;\n        texCoord += vec2(0.0, 2.0) * uTexSizeInv; // WebGL port note: Changed sign\n        if (!(texCoord.y > end && e.r > 0.8281 && e.g == 0.0)) break;\n    }\n\n    texCoord.y -= 0.25 * uTexSizeInv.y; // WebGL port note: Changed sign\n    texCoord.y -= uTexSizeInv.y; // WebGL port note: Changed sign\n    texCoord.y -= 2.0 * uTexSizeInv.y; // WebGL port note: Changed sign\n    texCoord.y += uTexSizeInv.y * SMAASearchLength(searchTex, e.gr, 0.0, 0.5); // WebGL port note: Changed sign\n\n    return texCoord.y;\n}\n\nfloat SMAASearchYDown(sampler2D edgesTex, sampler2D searchTex, vec2 texCoord, float end) {\n    vec2 e = vec2( 1.0, 0.0 );\n\n    for (int i = 0; i < dMaxSearchSteps; i++) { // WebGL port note: Changed while to for\n        e = texture2D(edgesTex, texCoord, 0.0).rg;\n        texCoord -= vec2( 0.0, 2.0 ) * uTexSizeInv; // WebGL port note: Changed sign\n        if (!(texCoord.y < end && e.r > 0.8281 && e.g == 0.0)) break;\n    }\n\n    texCoord.y += 0.25 * uTexSizeInv.y; // WebGL port note: Changed sign\n    texCoord.y += uTexSizeInv.y; // WebGL port note: Changed sign\n    texCoord.y += 2.0 * uTexSizeInv.y; // WebGL port note: Changed sign\n    texCoord.y -= uTexSizeInv.y * SMAASearchLength(searchTex, e.gr, 0.5, 0.5); // WebGL port note: Changed sign\n\n    return texCoord.y;\n}\n\nvec2 SMAAArea(sampler2D areaTex, vec2 dist, float e1, float e2, float offset) {\n    // Rounding prevents precision errors of bilinear filtering:\n    vec2 texCoord = float(SMAA_AREATEX_MAX_DISTANCE) * round(4.0 * vec2(e1, e2)) + dist;\n\n    // We do a scale and bias for mapping to texel space:\n    texCoord = SMAA_AREATEX_PIXEL_SIZE * texCoord + (0.5 * SMAA_AREATEX_PIXEL_SIZE);\n\n    // Move to proper place, according to the subpixel offset:\n    texCoord.y += SMAA_AREATEX_SUBTEX_SIZE * offset;\n\n    return texture2D(areaTex, texCoord, 0.0).rg;\n}\n\nvec4 SMAABlendingWeightCalculationPS(vec2 texCoord, vec2 pixCoord, vec4 offset[3], sampler2D edgesTex, sampler2D areaTex, sampler2D searchTex, ivec4 subsampleIndices) {\n    vec4 weights = vec4(0.0, 0.0, 0.0, 0.0);\n\n    vec2 e = texture2D(edgesTex, texCoord).rg;\n\n    if (e.g > 0.0) { // Edge at north\n        vec2 d;\n\n        // Find the distance to the left:\n        vec2 coords;\n        coords.x = SMAASearchXLeft(edgesTex, searchTex, offset[0].xy, offset[2].x );\n        coords.y = offset[1].y; // offset[1].y = texCoord.y - 0.25 * uTexSizeInv.y (@CROSSING_OFFSET)\n        d.x = coords.x;\n\n        // Now fetch the left crossing edges, two at a time using bilinear\n        // filtering. Sampling at -0.25 (see @CROSSING_OFFSET) enables to\n        // discern what value each edge has:\n        float e1 = texture2D(edgesTex, coords, 0.0).r;\n\n        // Find the distance to the right:\n        coords.x = SMAASearchXRight(edgesTex, searchTex, offset[0].zw, offset[2].y);\n        d.y = coords.x;\n\n        // We want the distances to be in pixel units (doing this here allow to\n        // better interleave arithmetic and memory accesses):\n        d = d / uTexSizeInv.x - pixCoord.x;\n\n        // SMAAArea below needs a sqrt, as the areas texture is compressed\n        // quadratically:\n        vec2 sqrt_d = sqrt(abs(d));\n\n        // Fetch the right crossing edges:\n        coords.y -= 1.0 * uTexSizeInv.y; // WebGL port note: Added\n        float e2 = SMAASampleLevelZeroOffset(edgesTex, coords, ivec2(1, 0)).r;\n\n        // Ok, we know how this pattern looks like, now it is time for getting\n        // the actual area:\n        weights.rg = SMAAArea(areaTex, sqrt_d, e1, e2, float(subsampleIndices.y));\n    }\n\n    if (e.r > 0.0) { // Edge at west\n        vec2 d;\n\n        // Find the distance to the top:\n        vec2 coords;\n\n        coords.y = SMAASearchYUp(edgesTex, searchTex, offset[1].xy, offset[2].z );\n        coords.x = offset[0].x; // offset[1].x = texCoord.x - 0.25 * uTexSizeInv.x;\n        d.x = coords.y;\n\n        // Fetch the top crossing edges:\n        float e1 = texture2D(edgesTex, coords, 0.0).g;\n\n        // Find the distance to the bottom:\n        coords.y = SMAASearchYDown(edgesTex, searchTex, offset[1].zw, offset[2].w);\n        d.y = coords.y;\n\n        // We want the distances to be in pixel units:\n        d = d / uTexSizeInv.y - pixCoord.y;\n\n        // SMAAArea below needs a sqrt, as the areas texture is compressed\n        // quadratically:\n        vec2 sqrt_d = sqrt(abs(d));\n\n        // Fetch the bottom crossing edges:\n        coords.y -= 1.0 * uTexSizeInv.y; // WebGL port note: Added\n        float e2 = SMAASampleLevelZeroOffset(edgesTex, coords, ivec2(0, 1)).g;\n\n        // Get the area for this direction:\n        weights.ba = SMAAArea(areaTex, sqrt_d, e1, e2, float(subsampleIndices.x));\n    }\n\n    return weights;\n}\n\nvoid main() {\n    gl_FragColor = SMAABlendingWeightCalculationPS(vUv, vPixCoord, vOffset, tEdges, tArea, tSearch, ivec4(0.0));\n}\n");var P=Object(n.__assign)(Object(n.__assign)({},i.b),{tColor:Object(a.i)("texture","rgba","ubyte","linear"),tWeights:Object(a.i)("texture","rgba","ubyte","linear"),uTexSizeInv:Object(a.j)("v2"),uViewport:Object(a.j)("v4")}),E=Object(o.g)("smaa-blend","\nprecision highp float;\n\nattribute vec2 aPosition;\nuniform vec2 uQuadScale;\n\nuniform vec2 uTexSizeInv;\nuniform vec4 uViewport;\n\nvarying vec2 vUv;\nvarying vec4 vOffset[2];\n\nvoid SMAANeighborhoodBlendingVS(vec2 texCoord) {\n    vOffset[0] = texCoord.xyxy + uTexSizeInv.xyxy * vec4(-1.0, 0.0, 0.0, 1.0); // WebGL port note: Changed sign in W component\n    vOffset[1] = texCoord.xyxy + uTexSizeInv.xyxy * vec4(1.0, 0.0, 0.0, -1.0); // WebGL port note: Changed sign in W component\n}\n\nvoid main() {\n    vec2 scale = uViewport.zw * uTexSizeInv;\n    vec2 shift = uViewport.xy * uTexSizeInv;\n    vUv = (aPosition + 1.0) * 0.5 * scale + shift;\n    SMAANeighborhoodBlendingVS(vUv);\n    vec2 position = aPosition * uQuadScale - vec2(1.0, 1.0) + uQuadScale;\n    gl_Position = vec4(position, 0.0, 1.0);\n}\n","\nprecision highp float;\nprecision highp int;\nprecision highp sampler2D;\n\nuniform sampler2D tWeights;\nuniform sampler2D tColor;\nuniform vec2 uTexSizeInv;\n\nvarying vec2 vUv;\nvarying vec4 vOffset[2];\n\nvec4 SMAANeighborhoodBlendingPS(vec2 texCoord, vec4 offset[2], sampler2D colorTex, sampler2D blendTex) {\n    // Fetch the blending weights for current pixel:\n    vec4 a;\n    a.xz = texture2D(blendTex, texCoord).xz;\n    a.y = texture2D(blendTex, offset[1].zw).g;\n    a.w = texture2D(blendTex, offset[1].xy).a;\n\n    // Is there any blending weight with a value greater than 0.0?\n    if (dot(a, vec4(1.0, 1.0, 1.0, 1.0)) < 1e-5) {\n        return texture2D(colorTex, texCoord, 0.0);\n    } else {\n        // Up to 4 lines can be crossing a pixel (one through each edge). We\n        // favor blending by choosing the line with the maximum weight for each\n        // direction:\n        vec2 offset;\n        offset.x = a.a > a.b ? a.a : -a.b; // left vs. right\n        offset.y = a.g > a.r ? -a.g : a.r; // top vs. bottom // WebGL port note: Changed signs\n\n        // Then we go in the direction that has the maximum weight:\n        if (abs(offset.x) > abs(offset.y)) { // horizontal vs. vertical\n            offset.y = 0.0;\n        } else {\n            offset.x = 0.0;\n        }\n\n        // Fetch the opposite color and lerp by hand:\n        vec4 C = texture2D(colorTex, texCoord, 0.0);\n        texCoord += sign(offset) * uTexSizeInv;\n        vec4 Cop = texture2D(colorTex, texCoord, 0.0);\n        float s = abs(offset.x) > abs(offset.y) ? abs(offset.x) : abs(offset.y);\n\n        // WebGL port note: Added gamma correction\n        C.xyz = pow(C.xyz, vec3(2.2));\n        Cop.xyz = pow(Cop.xyz, vec3(2.2));\n        vec4 mixed = mix(C, Cop, s);\n        mixed.xyz = pow(mixed.xyz, vec3(1.0 / 2.2));\n\n        return mixed;\n    }\n}\n\nvoid main() {\n    gl_FragColor = SMAANeighborhoodBlendingPS(vUv, vOffset, tColor, tWeights);\n}\n");var A=Object(n.__assign)(Object(n.__assign)({},i.b),{tDepth:Object(a.i)("texture","rgba","ubyte","nearest"),uTexSize:Object(a.j)("v2"),dOrthographic:Object(a.c)("number"),uNear:Object(a.j)("f"),uFar:Object(a.j)("f"),uMaxPossibleViewZDiff:Object(a.j)("f")});var D=Object(n.__assign)(Object(n.__assign)({},i.b),{tDepth:Object(a.i)("texture","rgba","ubyte","nearest"),uSamples:Object(a.j)("v3[]"),dNSamples:Object(a.c)("number"),uProjection:Object(a.j)("m4"),uInvProjection:Object(a.j)("m4"),uTexSize:Object(a.j)("v2"),uRadius:Object(a.j)("f"),uBias:Object(a.j)("f")});var T=Object(n.__assign)(Object(n.__assign)({},i.b),{tSsaoDepth:Object(a.i)("texture","rgba","ubyte","nearest"),uTexSize:Object(a.j)("v2"),uKernel:Object(a.j)("f[]"),dOcclusionKernelSize:Object(a.c)("number"),uBlurDirectionX:Object(a.j)("f"),uBlurDirectionY:Object(a.j)("f"),uMaxPossibleViewZDiff:Object(a.j)("f"),uNear:Object(a.j)("f"),uFar:Object(a.j)("f"),dOrthographic:Object(a.c)("number")});function I(e,t,r){var a=Object(n.__assign)(Object(n.__assign)({},i.c),{tSsaoDepth:s.e.create(t),uTexSize:s.e.create(l.Vec2.create(t.getWidth(),t.getHeight())),uKernel:s.e.create([0]),dOcclusionKernelSize:s.e.create(1),uBlurDirectionX:s.e.create("horizontal"===r?1:0),uBlurDirectionY:s.e.create("vertical"===r?1:0),uMaxPossibleViewZDiff:s.e.create(.5),uNear:s.e.create(0),uFar:s.e.create(1e4),dOrthographic:s.e.create(0)}),d=Object(n.__assign)({},T),p=Object(o.g)("ssao_blur",f.a,"\nprecision highp float;\nprecision highp int;\nprecision highp sampler2D;\n\nuniform sampler2D tSsaoDepth;\nuniform vec2 uTexSize;\n\nuniform float uKernel[dOcclusionKernelSize];\n\nuniform float uBlurDirectionX;\nuniform float uBlurDirectionY;\n\nuniform float uMaxPossibleViewZDiff;\n\nuniform float uNear;\nuniform float uFar;\n\n#include common\n\nfloat getViewZ(const in float depth) {\n    #if dOrthographic == 1\n        return orthographicDepthToViewZ(depth, uNear, uFar);\n    #else\n        return perspectiveDepthToViewZ(depth, uNear, uFar);\n    #endif\n}\n\nbool isBackground(const in float depth) {\n    return depth == 1.0;\n}\n\nvoid main(void) {\n    vec2 coords = gl_FragCoord.xy / uTexSize;\n\n    vec2 packedDepth = texture2D(tSsaoDepth, coords).zw;\n\n    float selfDepth = unpackRGToUnitInterval(packedDepth);\n    // if background and if second pass\n    if (isBackground(selfDepth) && uBlurDirectionY != 0.0) {\n       gl_FragColor = vec4(packUnitIntervalToRG(1.0), packedDepth);\n       return;\n    }\n\n    float selfViewZ = getViewZ(selfDepth);\n\n    vec2 offset = vec2(uBlurDirectionX, uBlurDirectionY) / uTexSize;\n\n    float sum = 0.0;\n    float kernelSum = 0.0;\n    // only if kernelSize is odd\n    for (int i = -dOcclusionKernelSize / 2; i <= dOcclusionKernelSize / 2; i++) {\n        vec2 sampleCoords = coords + float(i) * offset;\n\n        vec4 sampleSsaoDepth = texture2D(tSsaoDepth, sampleCoords);\n\n        float sampleDepth = unpackRGToUnitInterval(sampleSsaoDepth.zw);\n        if (isBackground(sampleDepth)) {\n            continue;\n        }\n\n        if (abs(float(i)) > 1.0) { // abs is not defined for int in webgl1\n            float sampleViewZ = getViewZ(sampleDepth);\n            if (abs(selfViewZ - sampleViewZ) > uMaxPossibleViewZDiff) {\n                continue;\n            }\n        }\n\n        float kernel = uKernel[int(abs(float(i)))]; // abs is not defined for int in webgl1\n        float sampleValue = unpackRGToUnitInterval(sampleSsaoDepth.xy);\n\n        sum += kernel * sampleValue;\n        kernelSum += kernel;\n    }\n\n    gl_FragColor = vec4(packUnitIntervalToRG(sum / kernelSum), packedDepth);\n}\n"),m=Object(u.a)(e,"triangles",p,d,a);return Object(c.a)(m,a)}var M=Object(n.__assign)(Object(n.__assign)({},i.b),{tSsaoDepth:Object(a.i)("texture","rgba","ubyte","nearest"),tColor:Object(a.i)("texture","rgba","ubyte","nearest"),tDepth:Object(a.i)("texture","rgba","ubyte","nearest"),tOutlines:Object(a.i)("texture","rgba","ubyte","nearest"),uTexSize:Object(a.j)("v2"),dOrthographic:Object(a.c)("number"),uNear:Object(a.j)("f"),uFar:Object(a.j)("f"),uFogNear:Object(a.j)("f"),uFogFar:Object(a.j)("f"),uFogColor:Object(a.j)("v3"),uTransparentBackground:Object(a.j)("b"),uMaxPossibleViewZDiff:Object(a.j)("f"),dOcclusionEnable:Object(a.c)("boolean"),dOutlineEnable:Object(a.c)("boolean"),dOutlineScale:Object(a.c)("number"),uOutlineThreshold:Object(a.j)("f")});var k={occlusion:d.ParamDefinition.MappedStatic("on",{on:d.ParamDefinition.Group({samples:d.ParamDefinition.Numeric(32,{min:1,max:256,step:1}),radius:d.ParamDefinition.Numeric(5,{min:0,max:10,step:.1},{description:"Final radius is 2^x."}),bias:d.ParamDefinition.Numeric(.8,{min:0,max:3,step:.1}),blurKernelSize:d.ParamDefinition.Numeric(15,{min:1,max:25,step:2})}),off:d.ParamDefinition.Group({})},{cycle:!0,description:"Darken occluded crevices with the ambient occlusion effect"}),outline:d.ParamDefinition.MappedStatic("off",{on:d.ParamDefinition.Group({scale:d.ParamDefinition.Numeric(1,{min:1,max:5,step:1}),threshold:d.ParamDefinition.Numeric(.33,{min:.01,max:1,step:.01})}),off:d.ParamDefinition.Group({})},{cycle:!0,description:"Draw outline around 3D objects"}),antialiasing:d.ParamDefinition.MappedStatic("smaa",{fxaa:d.ParamDefinition.Group(m),smaa:d.ParamDefinition.Group(S),off:d.ParamDefinition.Group({})},{options:[["fxaa","FXAA"],["smaa","SMAA"],["off","Off"]],description:"Smooth pixel edges"})},B=function(){function e(e,t){this.webgl=e,this.scale=1/this.webgl.pixelRatio;var r=t.colorTarget,a=t.depthTexture,d=r.getWidth(),p=r.getHeight();this.nSamples=1,this.blurKernelSize=1,this.target=e.createRenderTarget(d,p,!1,"uint8","linear"),this.outlinesTarget=e.createRenderTarget(d,p,!1),this.outlinesRenderable=function(e,t){var r=Object(n.__assign)(Object(n.__assign)({},i.c),{tDepth:s.e.create(t),uTexSize:s.e.create(l.Vec2.create(t.getWidth(),t.getHeight())),dOrthographic:s.e.create(0),uNear:s.e.create(1),uFar:s.e.create(1e4),uMaxPossibleViewZDiff:s.e.create(.5)}),a=Object(n.__assign)({},A),d=Object(o.g)("outlines",f.a,"\nprecision highp float;\nprecision highp int;\nprecision highp sampler2D;\n\nuniform sampler2D tDepth;\nuniform vec2 uTexSize;\n\nuniform float uNear;\nuniform float uFar;\n\nuniform float uMaxPossibleViewZDiff;\n\n#include common\n\nfloat getViewZ(const in float depth) {\n    #if dOrthographic == 1\n        return orthographicDepthToViewZ(depth, uNear, uFar);\n    #else\n        return perspectiveDepthToViewZ(depth, uNear, uFar);\n    #endif\n}\n\nfloat getDepth(const in vec2 coords) {\n    return unpackRGBAToDepth(texture2D(tDepth, coords));\n}\n\nbool isBackground(const in float depth) {\n    return depth == 1.0;\n}\n\nvoid main(void) {\n    float backgroundViewZ = uFar + 3.0 * uMaxPossibleViewZDiff;\n\n    vec2 coords = gl_FragCoord.xy / uTexSize;\n    vec2 invTexSize = 1.0 / uTexSize;\n\n    float selfDepth = getDepth(coords);\n    float selfViewZ = isBackground(selfDepth) ? backgroundViewZ : getViewZ(getDepth(coords));\n\n    float outline = 1.0;\n    float bestDepth = 1.0;\n\n    for (int y = -1; y <= 1; y++) {\n        for (int x = -1; x <= 1; x++) {\n            vec2 sampleCoords = coords + vec2(float(x), float(y)) * invTexSize;\n            float sampleDepth = getDepth(sampleCoords);\n            float sampleViewZ = isBackground(sampleDepth) ? backgroundViewZ : getViewZ(sampleDepth);\n\n            if (abs(selfViewZ - sampleViewZ) > uMaxPossibleViewZDiff && selfDepth > sampleDepth && sampleDepth <= bestDepth) {\n                outline = 0.0;\n                bestDepth = sampleDepth;\n            }\n        }\n    }\n\n    gl_FragColor = vec4(outline, packUnitIntervalToRG(bestDepth), 0.0);\n}\n"),p=Object(u.a)(e,"triangles",d,a,r);return Object(c.a)(p,r)}(e,a),this.randomHemisphereVector=[];for(var m=0;m<256;m++){var h=Object(l.Vec3)();h[0]=2*Math.random()-1,h[1]=2*Math.random()-1,h[2]=Math.random(),l.Vec3.normalize(h,h),l.Vec3.scale(h,h,Math.random()),this.randomHemisphereVector.push(h)}this.ssaoFramebuffer=e.resources.framebuffer(),this.ssaoBlurFirstPassFramebuffer=e.resources.framebuffer(),this.ssaoBlurSecondPassFramebuffer=e.resources.framebuffer();var g=Math.floor(d*this.scale),v=Math.floor(p*this.scale);this.ssaoDepthTexture=e.resources.texture("image-uint8","rgba","ubyte","linear"),this.ssaoDepthTexture.define(g,v),this.ssaoDepthTexture.attachFramebuffer(this.ssaoFramebuffer,"color0"),this.ssaoDepthBlurProxyTexture=e.resources.texture("image-uint8","rgba","ubyte","linear"),this.ssaoDepthBlurProxyTexture.define(g,v),this.ssaoDepthBlurProxyTexture.attachFramebuffer(this.ssaoBlurFirstPassFramebuffer,"color0"),this.ssaoDepthTexture.attachFramebuffer(this.ssaoBlurSecondPassFramebuffer,"color0"),this.ssaoRenderable=function(e,t){var r=Object(n.__assign)(Object(n.__assign)({},i.c),{tDepth:s.e.create(t),uSamples:s.e.create([0,0,1]),dNSamples:s.e.create(1),uProjection:s.e.create(l.Mat4.identity()),uInvProjection:s.e.create(l.Mat4.identity()),uTexSize:s.e.create(l.Vec2.create(e.gl.drawingBufferWidth,e.gl.drawingBufferHeight)),uRadius:s.e.create(8),uBias:s.e.create(.025)}),a=Object(n.__assign)({},D),d=Object(o.g)("ssao",f.a,"\nprecision highp float;\nprecision highp int;\nprecision highp sampler2D;\n\n#include common\n\nuniform sampler2D tDepth;\n\nuniform vec3 uSamples[dNSamples];\n\nuniform mat4 uProjection;\nuniform mat4 uInvProjection;\n\nuniform vec2 uTexSize;\n\nuniform float uRadius;\nuniform float uBias;\n\nfloat smootherstep(float edge0, float edge1, float x) {\n    x = clamp((x - edge0) / (edge1 - edge0), 0.0, 1.0);\n    return x * x * x * (x * (x * 6.0 - 15.0) + 10.0);\n}\n\nfloat noise(const in vec2 coords) {\n    float a = 12.9898;\n    float b = 78.233;\n    float c = 43758.5453;\n    float dt = dot(coords, vec2(a,b));\n    float sn = mod(dt, PI);\n    return abs(fract(sin(sn) * c)); // is abs necessary?\n}\n\nvec2 getNoiseVec2(const in vec2 coords) {\n    return vec2(noise(coords), noise(coords + vec2(PI, 2.71828)));\n}\n\nbool isBackground(const in float depth) {\n    return depth == 1.0;\n}\n\nfloat getDepth(const in vec2 coords) {\n    return unpackRGBAToDepth(texture2D(tDepth, coords));\n}\n\nvec3 normalFromDepth(const in float depth, const in float depth1, const in float depth2, vec2 offset1, vec2 offset2) {\n    vec3 p1 = vec3(offset1, depth1 - depth);\n    vec3 p2 = vec3(offset2, depth2 - depth);\n\n    vec3 normal = cross(p1, p2);\n    normal.z = -normal.z;\n\n    return normalize(normal);\n}\n\n// StarCraft II Ambient Occlusion by [Filion and McNaughton 2008]\nvoid main(void) {\n    vec2 invTexSize = 1.0 / uTexSize;\n    vec2 selfCoords = gl_FragCoord.xy * invTexSize;\n\n    float selfDepth = getDepth(selfCoords);\n    vec2 selfPackedDepth = packUnitIntervalToRG(selfDepth);\n\n    if (isBackground(selfDepth)) {\n        gl_FragColor = vec4(packUnitIntervalToRG(0.0), selfPackedDepth);\n        return;\n    }\n\n    vec2 offset1 = vec2(0.0, invTexSize.y);\n    vec2 offset2 = vec2(invTexSize.x, 0.0);\n\n    float selfDepth1 = getDepth(selfCoords + offset1);\n    float selfDepth2 = getDepth(selfCoords + offset2);\n\n    vec3 selfViewNormal = normalFromDepth(selfDepth, selfDepth1, selfDepth2, offset1, offset2);\n    vec3 selfViewPos = screenSpaceToViewSpace(vec3(selfCoords, selfDepth), uInvProjection);\n\n    vec3 randomVec = normalize(vec3(getNoiseVec2(selfCoords) * 2.0 - 1.0, 0.0));\n\n    vec3 tangent = normalize(randomVec - selfViewNormal * dot(randomVec, selfViewNormal));\n    vec3 bitangent = cross(selfViewNormal, tangent);\n    mat3 TBN = mat3(tangent, bitangent, selfViewNormal);\n\n    float occlusion = 0.0;\n    for(int i = 0; i < dNSamples; i++){\n        vec3 sampleViewPos = TBN * uSamples[i];\n        sampleViewPos = selfViewPos + sampleViewPos * uRadius;\n\n        vec4 offset = vec4(sampleViewPos, 1.0);\n        offset = uProjection * offset;\n        offset.xyz = (offset.xyz / offset.w) * 0.5 + 0.5;\n\n        float sampleViewZ = screenSpaceToViewSpace(vec3(offset.xy, getDepth(offset.xy)), uInvProjection).z;\n\n        occlusion += step(sampleViewPos.z + 0.025, sampleViewZ) * smootherstep(0.0, 1.0, uRadius / abs(selfViewPos.z - sampleViewZ));\n    }\n    occlusion = 1.0 - (uBias * occlusion / float(dNSamples));\n\n    vec2 packedOcclusion = packUnitIntervalToRG(occlusion);\n\n    gl_FragColor = vec4(packedOcclusion, selfPackedDepth);\n}\n"),p=Object(u.a)(e,"triangles",d,a,r);return Object(c.a)(p,r)}(e,a),this.ssaoBlurFirstPassRenderable=I(e,this.ssaoDepthTexture,"horizontal"),this.ssaoBlurSecondPassRenderable=I(e,this.ssaoDepthBlurProxyTexture,"vertical"),this.renderable=function(e,t,r,a,d){var p=Object(n.__assign)(Object(n.__assign)({},i.c),{tSsaoDepth:s.e.create(d),tColor:s.e.create(t),tDepth:s.e.create(r),tOutlines:s.e.create(a),uTexSize:s.e.create(l.Vec2.create(t.getWidth(),t.getHeight())),dOrthographic:s.e.create(0),uNear:s.e.create(1),uFar:s.e.create(1e4),uFogNear:s.e.create(1e4),uFogFar:s.e.create(1e4),uFogColor:s.e.create(l.Vec3.create(1,1,1)),uTransparentBackground:s.e.create(!1),uMaxPossibleViewZDiff:s.e.create(.5),dOcclusionEnable:s.e.create(!1),dOutlineEnable:s.e.create(!1),dOutlineScale:s.e.create(1),uOutlineThreshold:s.e.create(.33)}),m=Object(n.__assign)({},M),h=Object(o.g)("postprocessing",f.a,"\nprecision highp float;\nprecision highp int;\nprecision highp sampler2D;\n\nuniform sampler2D tSsaoDepth;\nuniform sampler2D tColor;\nuniform sampler2D tDepth;\nuniform sampler2D tOutlines;\nuniform vec2 uTexSize;\n\nuniform float uNear;\nuniform float uFar;\nuniform float uFogNear;\nuniform float uFogFar;\nuniform vec3 uFogColor;\nuniform bool uTransparentBackground;\n\nuniform float uOcclusionBias;\nuniform float uOcclusionRadius;\n\nuniform float uOutlineScale;\nuniform float uOutlineThreshold;\n\nuniform float uMaxPossibleViewZDiff;\n\nconst vec3 occlusionColor = vec3(0.0);\n\n#include common\n\nfloat getViewZ(const in float depth) {\n    #if dOrthographic == 1\n        return orthographicDepthToViewZ(depth, uNear, uFar);\n    #else\n        return perspectiveDepthToViewZ(depth, uNear, uFar);\n    #endif\n}\n\nfloat getDepth(const in vec2 coords) {\n    return unpackRGBAToDepth(texture2D(tDepth, coords));\n}\n\nbool isBackground(const in float depth) {\n    return depth == 1.0;\n}\n\nfloat getOutline(const in vec2 coords, out float closestTexel) {\n    float backgroundViewZ = uFar + 3.0 * uMaxPossibleViewZDiff;\n    vec2 invTexSize = 1.0 / uTexSize;\n\n    float selfDepth = getDepth(coords);\n    float selfViewZ = isBackground(selfDepth) ? backgroundViewZ : getViewZ(selfDepth);\n\n    float outline = 1.0;\n    closestTexel = 1.0;\n    for (int y = -dOutlineScale; y <= dOutlineScale; y++) {\n        for (int x = -dOutlineScale; x <= dOutlineScale; x++) {\n            if (x * x + y * y > dOutlineScale * dOutlineScale) {\n                continue;\n            }\n\n            vec2 sampleCoords = coords + vec2(float(x), float(y)) * invTexSize;\n\n            vec4 sampleOutlineCombined = texture2D(tOutlines, sampleCoords);\n            float sampleOutline = sampleOutlineCombined.r;\n            float sampleOutlineDepth = unpackRGToUnitInterval(sampleOutlineCombined.gb);\n\n            if (sampleOutline == 0.0 && sampleOutlineDepth < closestTexel && abs(selfViewZ - sampleOutlineDepth) > uMaxPossibleViewZDiff) {\n                outline = 0.0;\n                closestTexel = sampleOutlineDepth;\n            }\n        }\n    }\n    return outline;\n}\n\nfloat getSsao(vec2 coords) {\n    float rawSsao = unpackRGToUnitInterval(texture2D(tSsaoDepth, coords).xy);\n    if (rawSsao > 0.999) {\n        return 1.0;\n    } else if (rawSsao > 0.001) {\n        return rawSsao;\n    }\n    return 0.0;\n}\n\nvoid main(void) {\n    vec2 coords = gl_FragCoord.xy / uTexSize;\n    vec4 color = texture2D(tColor, coords);\n\n    float viewDist;\n    float fogFactor;\n\n    #ifdef dOcclusionEnable\n        float depth = getDepth(coords);\n        if (!isBackground(depth)) {\n            viewDist = abs(getViewZ(depth));\n            fogFactor = smoothstep(uFogNear, uFogFar, viewDist);\n            float occlusionFactor = getSsao(coords);\n            if (!uTransparentBackground) {\n                color.rgb = mix(mix(occlusionColor, uFogColor, fogFactor), color.rgb, occlusionFactor);\n            } else {\n                color.rgb = mix(occlusionColor * (1.0 - fogFactor), color.rgb, occlusionFactor);\n            }\n        }\n    #endif\n\n    // outline needs to be handled after occlusion to keep them clean\n    #ifdef dOutlineEnable\n        float closestTexel;\n        float outline = getOutline(coords, closestTexel);\n\n        if (outline == 0.0) {\n            color.rgb *= outline;\n            viewDist = abs(getViewZ(closestTexel));\n            fogFactor = smoothstep(uFogNear, uFogFar, viewDist);\n            if (!uTransparentBackground) {\n                color.rgb = mix(color.rgb, uFogColor, fogFactor);\n            } else {\n                color.a = 1.0 - fogFactor;\n            }\n        }\n    #endif\n\n    gl_FragColor = color;\n}\n"),g=Object(u.a)(e,"triangles",h,m,p);return Object(c.a)(g,p)}(e,r.texture,a,this.outlinesTarget.texture,this.ssaoDepthTexture)}return e.isEnabled=function(e){return"on"===e.occlusion.name||"on"===e.outline.name},e.prototype.setSize=function(e,t){var r=this.renderable.values.uTexSize.ref.value,n=r[0],i=r[1];if(e!==n||t!==i){var a=Math.floor(e*this.scale),o=Math.floor(t*this.scale);this.target.setSize(e,t),this.outlinesTarget.setSize(e,t),this.ssaoDepthTexture.define(a,o),this.ssaoDepthBlurProxyTexture.define(a,o),s.e.update(this.renderable.values.uTexSize,l.Vec2.set(this.renderable.values.uTexSize.ref.value,e,t)),s.e.update(this.outlinesRenderable.values.uTexSize,l.Vec2.set(this.outlinesRenderable.values.uTexSize.ref.value,e,t)),s.e.update(this.ssaoRenderable.values.uTexSize,l.Vec2.set(this.ssaoRenderable.values.uTexSize.ref.value,a,o)),s.e.update(this.ssaoBlurFirstPassRenderable.values.uTexSize,l.Vec2.set(this.ssaoRenderable.values.uTexSize.ref.value,a,o)),s.e.update(this.ssaoBlurSecondPassRenderable.values.uTexSize,l.Vec2.set(this.ssaoRenderable.values.uTexSize.ref.value,a,o))}},e.prototype.updateState=function(e,t,r,n){var i=!1,a=!1,o=!1,u="orthographic"===e.state.mode?1:0,c="on"===n.outline.name,d="on"===n.occlusion.name,f=l.Mat4.identity();if(l.Mat4.invert(f,e.projection),"on"===n.occlusion.name&&(s.e.updateIfChanged(this.ssaoRenderable.values.uProjection,e.projection),s.e.updateIfChanged(this.ssaoRenderable.values.uInvProjection,f),s.e.updateIfChanged(this.ssaoBlurFirstPassRenderable.values.uNear,e.near),s.e.updateIfChanged(this.ssaoBlurSecondPassRenderable.values.uNear,e.near),s.e.updateIfChanged(this.ssaoBlurFirstPassRenderable.values.uFar,e.far),s.e.updateIfChanged(this.ssaoBlurSecondPassRenderable.values.uFar,e.far),this.ssaoBlurFirstPassRenderable.values.dOrthographic.ref.value!==u&&(o=!0),s.e.updateIfChanged(this.ssaoBlurFirstPassRenderable.values.dOrthographic,u),s.e.updateIfChanged(this.ssaoBlurSecondPassRenderable.values.dOrthographic,u),this.nSamples!==n.occlusion.params.samples&&(a=!0,this.nSamples=n.occlusion.params.samples,s.e.updateIfChanged(this.ssaoRenderable.values.uSamples,function(e,t){for(var r=[],n=0;n<t;n++){var i=(n*n+2*n+1)/(t*t);i=.1+.9*i,r.push(e[n][0]*i),r.push(e[n][1]*i),r.push(e[n][2]*i)}return r}(this.randomHemisphereVector,this.nSamples)),s.e.updateIfChanged(this.ssaoRenderable.values.dNSamples,this.nSamples)),s.e.updateIfChanged(this.ssaoRenderable.values.uRadius,Math.pow(2,n.occlusion.params.radius)),s.e.updateIfChanged(this.ssaoRenderable.values.uBias,n.occlusion.params.bias),this.blurKernelSize!==n.occlusion.params.blurKernelSize)){o=!0,this.blurKernelSize=n.occlusion.params.blurKernelSize;var m=function(e){for(var t=e/3,r=Math.floor((e+1)/2),n=[],i=0;i<r;i++)n.push(1/(Math.sqrt(2*Math.PI)*t)*Math.exp(-i*i/(2*t*t)));return n}(this.blurKernelSize);s.e.updateIfChanged(this.ssaoBlurFirstPassRenderable.values.uKernel,m),s.e.updateIfChanged(this.ssaoBlurSecondPassRenderable.values.uKernel,m),s.e.updateIfChanged(this.ssaoBlurFirstPassRenderable.values.dOcclusionKernelSize,this.blurKernelSize),s.e.updateIfChanged(this.ssaoBlurSecondPassRenderable.values.dOcclusionKernelSize,this.blurKernelSize)}if("on"===n.outline.name){var h=Math.pow(1e3,n.outline.params.threshold)/1e3*(e.far-e.near),g=n.outline.params.scale-1;s.e.updateIfChanged(this.outlinesRenderable.values.uNear,e.near),s.e.updateIfChanged(this.outlinesRenderable.values.uFar,e.far),s.e.updateIfChanged(this.outlinesRenderable.values.uMaxPossibleViewZDiff,h),s.e.updateIfChanged(this.renderable.values.uMaxPossibleViewZDiff,h),s.e.updateIfChanged(this.renderable.values.uOutlineThreshold,n.outline.params.threshold),this.renderable.values.dOutlineScale.ref.value!==g&&(i=!0),s.e.updateIfChanged(this.renderable.values.dOutlineScale,g)}s.e.updateIfChanged(this.renderable.values.uFar,e.far),s.e.updateIfChanged(this.renderable.values.uNear,e.near),s.e.updateIfChanged(this.renderable.values.uFogFar,e.fogFar),s.e.updateIfChanged(this.renderable.values.uFogNear,e.fogNear),s.e.update(this.renderable.values.uFogColor,p.Color.toVec3Normalized(this.renderable.values.uFogColor.ref.value,r)),s.e.updateIfChanged(this.renderable.values.uTransparentBackground,t),this.renderable.values.dOrthographic.ref.value!==u&&(i=!0),s.e.updateIfChanged(this.renderable.values.dOrthographic,u),this.renderable.values.dOutlineEnable.ref.value!==c&&(i=!0),s.e.updateIfChanged(this.renderable.values.dOutlineEnable,c),this.renderable.values.dOcclusionEnable.ref.value!==d&&(i=!0),s.e.updateIfChanged(this.renderable.values.dOcclusionEnable,d),a&&this.ssaoRenderable.update(),o&&(this.ssaoBlurFirstPassRenderable.update(),this.ssaoBlurSecondPassRenderable.update()),i&&this.renderable.update();var v=this.webgl,b=v.gl,y=v.state;y.enable(b.SCISSOR_TEST),y.disable(b.BLEND),y.disable(b.DEPTH_TEST),y.depthMask(!1);var _=e.viewport,S=_.x,x=_.y,O=_.width,w=_.height;b.viewport(S,x,O,w),b.scissor(S,x,O,w)},e.prototype.render=function(e,t,r,n,i){if(this.updateState(e,r,n,i),"on"===i.outline.name&&(this.outlinesTarget.bind(),this.outlinesRenderable.render()),"on"===i.occlusion.name){var a=e.viewport,o=a.x,s=a.y,u=a.width,c=a.height,l=Math.floor(o*this.scale),d=Math.floor(s*this.scale),f=Math.floor(u*this.scale),p=Math.floor(c*this.scale);this.webgl.gl.viewport(l,d,f,p),this.webgl.gl.scissor(l,d,f,p),this.ssaoFramebuffer.bind(),this.ssaoRenderable.render(),this.ssaoBlurFirstPassFramebuffer.bind(),this.ssaoBlurFirstPassRenderable.render(),this.ssaoBlurSecondPassFramebuffer.bind(),this.ssaoBlurSecondPassRenderable.render(),this.webgl.gl.viewport(o,s,u,c),this.webgl.gl.scissor(o,s,u,c)}t?this.webgl.unbindFramebuffer():this.target.bind();var m=this.webgl,h=m.gl;m.state.clearColor(0,0,0,1),h.clear(h.COLOR_BUFFER_BIT),this.renderable.render()},e}(),V=function(){function e(e,t){this.drawPass=t;var r=t.colorTarget,n=r.getWidth(),i=r.getHeight();this.target=e.createRenderTarget(n,i,!1),this.fxaa=new h(e,this.target.texture),this.smaa=new x(e,this.target.texture)}return e.isEnabled=function(e){return"off"!==e.antialiasing.name},e.prototype.setSize=function(e,t){var r=this.target.texture.getWidth(),n=this.target.texture.getHeight();e===r&&t===n||(this.target.setSize(e,t),this.fxaa.setSize(e,t),this.smaa.supported&&this.smaa.setSize(e,t))},e.prototype._renderFxaa=function(e,t,r){if("fxaa"===r.antialiasing.name){var n=B.isEnabled(r)?this.drawPass.postprocessing.target.texture:this.drawPass.colorTarget.texture;this.fxaa.update(n,r.antialiasing.params),this.fxaa.render(e.viewport,t?void 0:this.target)}},e.prototype._renderSmaa=function(e,t,r){if("smaa"===r.antialiasing.name){var n=B.isEnabled(r)?this.drawPass.postprocessing.target.texture:this.drawPass.colorTarget.texture;this.smaa.update(n,r.antialiasing.params),this.smaa.render(e.viewport,t?void 0:this.target)}},e.prototype.render=function(e,t,r){if("off"!==r.antialiasing.name)if("fxaa"===r.antialiasing.name)this._renderFxaa(e,t,r);else if("smaa"===r.antialiasing.name){if(!this.smaa.supported)throw new Error('SMAA not supported, missing "HTMLImageElement"');this._renderSmaa(e,t,r)}},e}()},function(e,t,r){"use strict";r.d(t,"a",(function(){return se}));var n=r(0),i=r(7),a=r(200),o=r(361),s=r(66),u=r(6),c=r(120),l=r(313),d=r(12);function f(e,t){return t?1===t.length?Object(d.f)(t.charCodeAt(0),e):2===t.length?Object(d.f)(t.charCodeAt(0),Object(d.f)(t.charCodeAt(1),e)):e+" "+t:e}function p(e,t,r,n){if(e.has(t)){(i=e.get(t)).has(r)||i.set(r,n)}else{var i=new Map;e.set(t,i),i.set(r,n)}}function m(e){throw new Error("Missing entity entry for entity id '"+e+"'.")}var h=l.b.EmptyResidueKey(),g=function(){function e(e){this.map=e,this.entityIndex=e.entities.getEntityIndex,this.residueOffsets=this.map.segments.residueAtomSegments.offsets}return e.prototype.getEntityFromChain=function(e){return this.map.chain_index_entity_index[e]},e.prototype.findEntity=function(e){var t=this.map.label_asym_id.get(e);return void 0!==t?t:-1},e.prototype.findChainLabel=function(e){var t=this.entityIndex(e.label_entity_id);if(t<0||!this.map.entity_index_label_asym_id.has(t))return-1;var r=this.map.entity_index_label_asym_id.get(t);return r&&r.has(e.label_asym_id)?r.get(e.label_asym_id):-1},e.prototype.findChainAuth=function(e){if(!this.map.auth_asym_id_auth_seq_id.has(e.auth_asym_id))return-1;var t=this.map.auth_asym_id_auth_seq_id.get(e.auth_asym_id);return t.has(e.auth_seq_id)?t.get(e.auth_seq_id):-1},e.prototype.findResidue=function(e,t,r,n){var i;1===arguments.length?i=e:(h.label_entity_id=e,h.label_asym_id=t,h.auth_seq_id=r,h.pdbx_PDB_ins_code=n,i=h);var a=this.findChainLabel(i);if(a<0)return-1;var o=this.map.chain_index_auth_seq_id.get(a),s=f(i.auth_seq_id,i.pdbx_PDB_ins_code||"");return o.has(s)?o.get(s):-1},e.prototype.findResidueAuth=function(e){var t=this.findChainAuth(e);if(t<0)return-1;var r=this.map.chain_index_auth_seq_id.get(t),n=f(e.auth_seq_id,e.pdbx_PDB_ins_code||"");return r.has(n)?r.get(n):-1},e.prototype.findResidueInsertion=function(e){var t=this.findChainLabel(e);if(t<0)return-1;var r=this.map.chain_index_label_seq_id.get(t),n=f(e.label_seq_id,e.pdbx_PDB_ins_code||"");if(r.has(n))return r.get(n);var i=u.SortedArray.findPredecessorIndex(this.map.label_seq_id,e.label_seq_id),a=l.a.chainStartResidueIndex(this.map.segments,t);if(i<a)return a;var o=l.a.chainEndResidueIndexExcl(this.map.segments,t)-1;return i>=o?o:i},e.prototype.findAtom=function(e){var t=this.findResidue(e);return t<0?-1:void 0===e.label_alt_id?v(this.residueOffsets[t],this.residueOffsets[t+1],this.map.label_atom_id,e.label_atom_id):b(this.residueOffsets[t],this.residueOffsets[t+1],this.map.label_atom_id,this.map.label_alt_id,e.label_atom_id,e.label_alt_id)},e.prototype.findAtomAuth=function(e){var t=this.findResidueAuth(e);return t<0?-1:void 0===e.label_alt_id?v(this.residueOffsets[t],this.residueOffsets[t+1],this.map.auth_atom_id,e.auth_atom_id):b(this.residueOffsets[t],this.residueOffsets[t+1],this.map.auth_atom_id,this.map.label_alt_id,e.auth_atom_id,e.label_alt_id)},e.prototype.findAtomOnResidue=function(e,t,r){return void 0===r?v(this.residueOffsets[e],this.residueOffsets[e+1],this.map.label_atom_id,t):b(this.residueOffsets[e],this.residueOffsets[e+1],this.map.label_atom_id,this.map.label_alt_id,t,r)},e.prototype.findAtomsOnResidue=function(e,t){return function(e,t,r,n){for(var i=e;i<t;i++)if(n.has(r.value(i)))return i;return-1}(this.residueOffsets[e],this.residueOffsets[e+1],this.map.label_atom_id,t)},e}();function v(e,t,r,n){for(var i=e;i<t;i++)if(r.value(i)===n)return i;return-1}function b(e,t,r,n,i,a){for(var o=e;o<t;o++)if(r.value(o)===i&&n.value(o)===a)return o;return-1}function y(e,t,r){for(var n=function(e,t,r){return{entities:e,segments:r,label_seq_id:u.SortedArray.ofSortedArray(t.residues.label_seq_id.toArray({array:Int32Array})),label_atom_id:t.atoms.label_atom_id,auth_atom_id:t.atoms.auth_atom_id,label_alt_id:t.atoms.label_alt_id,chain_index_entity_index:new Int32Array(t.chains._rowCount),entity_index_label_asym_id:new Map,chain_index_label_seq_id:new Map,auth_asym_id_auth_seq_id:new Map,chain_index_auth_seq_id:new Map,label_asym_id:new Map}}(t,e,r),i=e.residues,a=i.label_seq_id,o=i.auth_seq_id,s=i.pdbx_PDB_ins_code,c=e.chains,l=c.label_entity_id,d=c.label_asym_id,h=c.auth_asym_id,v=u.Interval.ofBounds(0,e.atoms._rowCount),b=u.Segmentation.transientSegments(r.chainAtomSegments,v);b.hasNext;){var y=b.move(),_=y.index,S=t.getEntityIndex(l.value(_));S<0&&m(l.value(_)),n.chain_index_entity_index[_]=S;var x=h.value(_),O=n.auth_asym_id_auth_seq_id.get(x);O||(O=new Map,n.auth_asym_id_auth_seq_id.set(x,O));var w=d.value(_);n.label_asym_id.has(w)||n.label_asym_id.set(w,S),p(n.entity_index_label_asym_id,S,w,_);var C=new Map,j=new Map;n.chain_index_label_seq_id.set(_,C),n.chain_index_auth_seq_id.set(_,j);for(var P=u.Segmentation.transientSegments(r.residueAtomSegments,v,y);P.hasNext;){var E=P.move().index,A=o.value(E),D=s.value(E);C.set(f(a.value(E),D),E),j.set(f(A,D),E),O.set(A,_)}}return new g(n)}var _=r(22),S=r(150),x=r(48);var O,w=r(9),C=r(74),j=r(333),P=r(152),E=r(1);function A(e,t,r){e[t].isDefined||(e[t]=e[r]),e[r].isDefined||(e[r]=e[t])}function D(e,t,r,a,o,s){var l,d,f=function(e){if(0===e._rowCount)return{residues:[],chains:[]};for(var t=e._rowCount,r=[0],n=[0],i=e.label_entity_id,a=e.label_asym_id,o=e.label_seq_id,s=e.auth_seq_id,u=e.pdbx_PDB_ins_code,c=1;c<t;c++){var l=!i.areValuesEqual(c-1,c)||!a.areValuesEqual(c-1,c);(l||!o.areValuesEqual(c-1,c)||!s.areValuesEqual(c-1,c)||!u.areValuesEqual(c-1,c))&&(r[r.length]=c),l&&(n[n.length]=c)}return{residues:r,chains:n}}(e),p=function(e,t,r){var n=i.d.ofColumns(c.e,{type_symbol:i.a.ofArray({array:i.a.mapToArray(e.type_symbol,_.ElementSymbol),schema:i.a.Schema.Aliased(i.a.Schema.str)}),label_atom_id:e.label_atom_id,auth_atom_id:e.auth_atom_id,label_alt_id:e.label_alt_id,label_comp_id:e.label_comp_id,auth_comp_id:e.auth_comp_id,pdbx_formal_charge:e.pdbx_formal_charge}),a=i.d.view(e,c.g,r.residues),o=i.d.view(e,c.f,r.chains);if(!a.label_seq_id.isDefined){for(var s=new Int32Array(a.label_seq_id.rowCount),u=r.residues,l=r.chains,d=0,f=0,p=0,m=s.length;p<m;++p)u[p]>l[d+1]&&(d+=1,f=0),s[p]=++f;a.label_seq_id=i.a.ofIntArray(s)}return i.d.columnToArray(a,"label_seq_id",Int32Array),i.d.columnToArray(a,"auth_seq_id",Int32Array),A(n,"label_atom_id","auth_atom_id"),A(n,"label_comp_id","auth_comp_id"),A(a,"label_seq_id","auth_seq_id"),A(o,"label_asym_id","auth_asym_id"),{atoms:n,residues:a,chains:o,atomSourceIndex:t}}(e,t,f),m=function(e,t){var r=new Map;if(!C.a.is(t))return r;var n=Object(P.a)(j.a,t.data.frame).molstar_atom_site_operator_mapping;if(0===n._rowCount)return r;for(var a=new Map,o=new Map,s=0;s<n._rowCount;s++){var u=0===n.assembly_operator_id.valueKind(s)?{id:n.assembly_id.value(s),operList:[],operId:n.assembly_operator_id.value(s)}:void 0,c=w.h.create(n.operator_name.value(s),E.Mat4.identity(),{assembly:u,spgrOp:0===n.symmetry_operator_index.valueKind(s)?n.symmetry_operator_index.value(s):void 0,hkl:E.Vec3.ofArray(n.symmetry_hkl.value(s)),ncsId:n.ncs_id.value(s)}),l=n.suffix.value(s),d=n.label_asym_id.value(s);a.set(""+d+l,{name:d,operator:c});var f=n.auth_asym_id.value(s);o.set(""+f+l,f)}var p=e.chains,m=p.label_asym_id,h=p.auth_asym_id,g=new Array(m.rowCount),v=new Array(m.rowCount);for(s=0;s<m.rowCount;s++){d=m.value(s),f=h.value(s);if(a.has(d)){var b=a.get(d),y=b.name;c=b.operator;r.set(s,c),g[s]=y,v[s]=o.get(f)||f}else g[s]=d,v[s]=f}return e.chains.label_asym_id=i.a.ofArray({array:g,valueKind:e.chains.label_asym_id.valueKind,schema:e.chains.label_asym_id.schema}),e.chains.auth_asym_id=i.a.ofArray({array:v,valueKind:e.chains.auth_asym_id.valueKind,schema:e.chains.auth_asym_id.schema}),r}(p,o);if(s&&(l=s.atomicHierarchy,d=p,i.d.areEqual(l.chains,d.chains)&&i.d.areEqual(l.residues,d.residues)&&i.d.areEqual(l.atoms,d.atoms)))return{sameAsPrevious:!0,hierarchy:s.atomicHierarchy,chainOperatorMapping:m};var h={residueAtomSegments:u.Segmentation.ofOffsets(f.residues,u.Interval.ofBounds(0,e._rowCount)),chainAtomSegments:u.Segmentation.ofOffsets(f.chains,u.Interval.ofBounds(0,e._rowCount))},g=y(p,r,h),v=function(e,t,r,n){for(var i=e.atoms,a=i.label_comp_id,o=i.type_symbol,s=i._rowCount,u=e.residues._rowCount,l=t.residueAtomSegments.offsets,d=new Uint8Array(s),f=0;f<s;++f)d[f]=Object(c.a)(o.value(f));var p=new Int32Array(u),m=new Int32Array(u),h=new Int32Array(u),g=new Uint8Array(u),v=new Uint8Array(u),b=new Map,y=new Map;for(f=0;f<u;++f){var O=a.value(l[f]),w=n,C=void 0,j=void 0;if(b.has(O))C=b.get(O),j=y.get(O);else{var P=void 0;w.has(O)?P=w.get(O).type:(x.b||console.info("chemComp not found",O),P=Object(_.getComponentType)(O)),C=Object(_.getMoleculeType)(P,O),j=Object(_.getPolymerType)(P,C),b.set(O,C),y.set(O,j)}g[f]=C,v[f]=j;var E=Object(S.a)(j,"trace"),A=r.findAtomsOnResidue(f,E);if(-1===A){var D=Object(S.a)(j,"coarseBackbone");A=r.findAtomsOnResidue(f,D)}p[f]=A;var T=Object(S.a)(j,"directionFrom");m[f]=r.findAtomsOnResidue(f,T);var I=Object(S.a)(j,"directionTo");h[f]=r.findAtomsOnResidue(f,I)}return{atom:{atomicNumber:d},residue:{traceElementIndex:p,directionFromElementIndex:m,directionToElementIndex:h,moleculeType:g,polymerType:v}}}(p,h,g,a);return{sameAsPrevious:!1,hierarchy:Object(n.__assign)(Object(n.__assign)(Object(n.__assign)({},p),h),{index:g,derived:v}),chainOperatorMapping:m}}function T(e,t,r,n,i,o){var s=D(e,t,r,n,i,o),u=s.sameAsPrevious,c=s.hierarchy,l=s.chainOperatorMapping;return{sameAsPrevious:u,hierarchy:c,conformation:function(e){return{id:a.a.create22(),atomId:e.id,occupancy:e.occupancy,B_iso_or_equiv:e.B_iso_or_equiv,xyzDefined:e.Cartn_x.isDefined&&e.Cartn_y.isDefined&&e.Cartn_z.isDefined,x:e.Cartn_x.toArray({array:Float32Array}),y:e.Cartn_y.toArray({array:Float32Array}),z:e.Cartn_z.toArray({array:Float32Array})}}(e),chainOperatorMapping:l}}!function(e){e.Empty={isDefined:!1}}(O||(O={}));var I=r(88);function M(e,t,r){if(e.has(t))return e.get(t);var n=r.index++;return e.set(t,n),n}function k(e,t){if(e.has(t))return e.get(t);var r=new Map;return e.set(t,r),r}function B(e){throw new Error("Missing entity entry for entity id '"+e+"'.")}function V(e,t){for(var r=e.entity_id,n=e.asym_id,i=e.seq_id_begin,a=e.seq_id_end,o=e.count,s=e.chainElementSegments,c=new Map,l=new Map,d={index:0},f=new Int32Array(o),p=new Int32Array(o),m=new Int32Array(s.count),h=0;h<o;h++)p[h]=t.getEntityIndex(r.value(h)),p[h]<0&&B(r.value(h));for(var g=0;g<s.count;g++){var v=s.offsets[g],b=s.offsets[g+1],y=p[v];m[g]=y;var _=M(k(l,y),n.value(v),d);for(h=v;h<b;h++)f[h]=_;var S=[],x=[];for(h=v;h<b;h++){var O=i.value(h),w=a.value(h);S.push(h),x.push(O,w)}var C={elementIndices:S,seqRanges:I.a.ofSortedRanges(x)};c.set(_,C)}var j=function(e,t,r){var n=e.getEntityIndex;return{findChainKey:function(e,r){var i=n(e);if(i<0)return-1;var a=t.get(i);return a.has(r)?a.get(r):-1},findSequenceKey:function(e,i,a){var o=n(e);if(o<0)return-1;var s=t.get(o);if(void 0===s)return-1;var c=s.get(i);if(void 0===c)return-1;var l=r.get(c),d=l.elementIndices,f=l.seqRanges,p=I.a.firstIntersectionIndex(f,u.OrderedSet.ofSingleton(a));return-1!==p?d[p]:-1}}}(t,l,c),P=j.findChainKey;return{chainKey:f,entityKey:p,findSequenceKey:j.findSequenceKey,findChainKey:P,getEntityFromChain:function(e){return m[e]}}}var R=r(5);function L(e,t){for(var r=[],n=[],i=u.Segmentation.transientSegments(e.chainElementSegments,u.Interval.ofBounds(0,e.count)),a=e.seq_id_begin,o=e.seq_id_end;i.hasNext;)for(var s=i.move(),c=s.start,l=s.end,d=-1,f=-1,p=c;p<l;++p){var m=o.value(p);p===c?(d=p,f=o.value(p)):a.value(p)-f>1&&(r.push(d,p-1),n.push(p-1,p),d=p),p===l-1&&r.push(d,p),f=m}return{polymerRanges:I.a.ofSortedRanges(r),gapRanges:I.a.ofSortedRanges(n)}}var N=r(111),F={hierarchy:O.Empty,conformation:void 0};function U(e,t){var r=e.ihm_sphere_obj_site,i=e.ihm_gaussian_obj_site;if(0===r._rowCount&&0===i._rowCount)return F;var a=z(r),o=function(e){return{x:e.Cartn_x.toArray({array:Float32Array}),y:e.Cartn_y.toArray({array:Float32Array}),z:e.Cartn_z.toArray({array:Float32Array}),radius:e.object_radius.toArray({array:Float32Array}),rmsf:e.rmsf.toArray({array:Float32Array})}}(r),s=V(a,e.entities),u=L(a,t.chemicalComponentMap),c=z(i),l=function(e){for(var t=N.a.ihm_gaussian_obj_site.covariance_matrix.space,r=[],n=e.covariance_matrix,i=0,a=n.rowCount;i<a;i++)r[i]=E.Tensor.toMat3(Object(E.Mat3)(),t,n.value(i));return{x:e.mean_Cartn_x.toArray({array:Float32Array}),y:e.mean_Cartn_y.toArray({array:Float32Array}),z:e.mean_Cartn_z.toArray({array:Float32Array}),weight:e.weight.toArray({array:Float32Array}),covariance_matrix:r}}(i),d=V(c,e.entities),f=L(c,t.chemicalComponentMap);return{hierarchy:{isDefined:!0,spheres:Object(n.__assign)(Object(n.__assign)(Object(n.__assign)({},a),s),u),gaussians:Object(n.__assign)(Object(n.__assign)(Object(n.__assign)({},c),d),f)},conformation:{id:R.c.create22(),spheres:o,gaussians:l}}}function z(e){var t=e.entity_id,r=e.seq_id_begin,i=e.seq_id_end,a=e.asym_id;return Object(n.__assign)({count:t.rowCount,entity_id:t,asym_id:a,seq_id_begin:r,seq_id_end:i},function(e,t,r){for(var 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f=n.findAtomsOnResidue(e,Object(S.a)(l,"backboneStart")),p=n.findAtomsOnResidue(t,Object(S.a)(d,"backboneEnd"));-1!==f&&-1!==p||(f=n.findAtomsOnResidue(e,Object(S.a)(l,"coarseBackbone")),p=n.findAtomsOnResidue(t,Object(S.a)(d,"coarseBackbone")));var m=r.x,h=r.y,g=r.z,v=E.Vec3.create(m[f],h[f],g[f]),b=E.Vec3.create(m[p],h[p],g[p]),y=-1===u[e]||-1===c[e]||-1===u[t]||-1===c[t];return E.Vec3.distance(v,b)<(y?10:3)}function Q(e,t,r,n){for(var i,a,o,s,c=[],l=[],d=new Map,f=u.Segmentation.transientSegments(e.chainAtomSegments,u.Interval.ofBounds(0,e.atoms._rowCount)),p=u.Segmentation.transientSegments(e.residueAtomSegments,u.Interval.ofBounds(0,e.atoms._rowCount)),m=e.index,h=e.derived,g=e.residues.label_seq_id,v=e.chains.label_entity_id,b=h.residue,y=b.moleculeType,S=b.traceElementIndex;f.hasNext;){var x=f.move();p.setSegment(x),i=-1,a=-1,o=-1,s=-1;var O=t.getEntityIndex(v.value(x.index)),w=n.byEntityKey[O],C=w?w.sequence.seqId.value(w.sequence.seqId.rowCount-1):-1,j=e.residueAtomSegments.index[x.start],P=e.residueAtomSegments.index[x.end-1],E=g.value(j),A=g.value(P);for(1===E&&A===C&&r.xyzDefined&&Y(j,P,r,m,h)&&(d.set(j,P),d.set(P,j));p.hasNext;){var D=p.move(),T=D.index,M=g.value(T);if(Object(_.isPolymer)(y[T])&&-1!==S[T])if(-1!==s)if(M!==i+1)c.push(s,o-1),l.push(a,D.end-1),s=D.start;else if(p.hasNext){var k=e.residueAtomSegments.index[D.start],B=e.residueAtomSegments.index[o-1];r.xyzDefined&&!Y(k,B,r,e.index,h)&&(c.push(s,o-1),l.push(a,D.end-1),s=D.start)}else c.push(s,D.end-1);else s=D.start;else-1!==s&&(c.push(s,o-1),s=-1);a=D.start,o=D.end,i=M}}return{polymerRanges:I.a.ofSortedRanges(c),gapRanges:I.a.ofSortedRanges(l),cyclicPolymerMap:d}}var K=r(184),Z=r(154);function J(e){for(var t=new Map,r=function(e,t,r){return e+"|"+t+"|"+r},n=e.pdbx_unobs_or_zero_occ_residues,i=0,a=n._rowCount;i<a;++i){var 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l&&d.push(l),0===e.struct.title.valueKind(0)&&d.push(e.struct.title.value(0)),t.model_name&&d.push(t.model_name),t.model_group_name&&d.push(t.model_group_name),{id:a.a.create22(),entryId:l,label:d.join(" | "),entry:l,sourceData:n,modelNum:t.model_id,parent:void 0,entities:t.entities,sequence:u,atomicHierarchy:i.hierarchy,atomicConformation:i.conformation,atomicRanges:c,atomicChainOperatorMappinng:i.chainOperatorMapping,coarseHierarchy:o.hierarchy,coarseConformation:o.conformation,properties:r,customProperties:new s.CustomProperties,_staticPropertyData:Object.create(null),_dynamicPropertyData:Object.create(null)}}(t,C,r,o),p.push(j),n.label=5;case 5:return v++,[3,1];case 6:return[2,p]}}))}))}},function(e,t,r){"use strict";var n=r(37),i=r(120),a=r(181),o=r(9);function s(){throw"Property only available for atomic models."}function u(e){if(e)throw"Property only available for coarse models ("+e+").";throw"Property only available for coarse models."}var c={key:function(e){return 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r=i(e,t);return-1===r?-1:n(B.StructureProperties.atom.label_comp_id(e),r)}e.compute=function(e,r){var n=this;void 0===r&&(r={});var i=Object(C.__assign)(Object(C.__assign)({},P.ParamDefinition.getDefaultValues(ae)),r);return L.b.create("Compute Accessible Surface Area",(function(r){return Object(C.__awaiter)(n,void 0,void 0,(function(){return Object(C.__generator)(this,(function(n){switch(n.label){case 0:return[4,t(r,e,i)];case 1:return[2,n.sent()]}}))}))}))},e.normalize=n,e.getValue=i,e.getNormalizedValue=a,e.getFlag=function(e,t){var r=a(e,t);return-1===r?0:r<.16?1:2}}(ie||(ie={}));var oe=r(212),se=r(169),ue=r(19),ce=r(16),le=r(66),de=Object(C.__assign)({},ae),fe={isBuried:se.QuerySymbolRuntime.Dynamic(Object(ue.c)("computed","accessible-surface-area.is-buried",ce.a.Bool),(function(e){if(!B.Unit.isAtomic(e.element.unit))return!1;var t=pe.get(e.element.structure).value;return!!t&&1===ie.getFlag(e.element,t)})),isAccessible:se.QuerySymbolRuntime.Dynamic(Object(ue.c)("computed","accessible-surface-area.is-accessible",ce.a.Bool),(function(e){if(!B.Unit.isAtomic(e.element.unit))return!1;var t=pe.get(e.element.structure).value;return!!t&&2===ie.getFlag(e.element,t)}))},pe=oe.a.createProvider({label:"Accessible Surface Area",descriptor:Object(le.CustomPropertyDescriptor)({name:"molstar_accessible_surface_area",symbols:fe}),type:"root",defaultParams:de,getParams:function(e){return de},isApplicable:function(e){return!0},obtain:function(e,t,r){return Object(C.__awaiter)(void 0,void 0,void 0,(function(){var n,i;return Object(C.__generator)(this,(function(a){switch(a.label){case 0:return n=Object(C.__assign)(Object(C.__assign)({},P.ParamDefinition.getDefaultValues(de)),r),i={},[4,ie.compute(t,n).runInContext(e.runtime)];case 1:return[2,(i.value=a.sent(),i)]}}))}))}}),me=r(24),he=r(12),ge=Object(me.Color)(16448250),ve={list:P.ParamDefinition.ColorList("rainbow",{presetKind:"scale"})};var be={name:"accessible-surface-area",label:"Accessible Surface Area",category:"Residue Property",factory:function e(t,r){var n,i=me.ColorScale.create({listOrName:r.list.colors,minLabel:"buried",maxLabel:"exposed",domain:[0,1]}),a=t.structure&&pe.get(t.structure),o=a?Object(he.i)(a.id,a.version):-1;if((null==a?void 0:a.value)&&t.structure){var s=B.StructureElement.Location.create(t.structure),u=a.value,c=function(e){var t=ie.getNormalizedValue(e,u);return-1===t?ge:i.color(t)};n=function(e){return B.StructureElement.Location.is(e)&&B.Unit.isAtomic(e.unit)?c(e):B.Bond.isLocation(e)?(s.unit=e.aUnit,s.element=e.aUnit.elements[e.aIndex],c(s)):ge}}else n=function(){return ge};return{factory:e,granularity:"group",color:n,props:r,contextHash:o,description:"Assigns a color based on the relative accessible surface area of a 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this.params.autoAttach=e.autoAttach,this.params.showTooltip=e.showTooltip,this.ctx.customStructureProperties.setDefaultAutoAttach(this.provider.descriptor.name,this.params.autoAttach),t},t.prototype.register=function(){se.DefaultQueryRuntimeTable.addCustomProp(this.provider.descriptor),this.ctx.customStructureProperties.register(this.provider,this.params.autoAttach),this.ctx.representation.structure.themes.colorThemeRegistry.add(be),this.ctx.managers.lociLabels.addProvider(this.labelProvider),this.ctx.query.structure.registry.add(Pe),this.ctx.query.structure.registry.add(Ee)},t.prototype.unregister=function(){se.DefaultQueryRuntimeTable.removeCustomProp(this.provider.descriptor),this.ctx.customStructureProperties.unregister(this.provider.descriptor.name),this.ctx.representation.structure.themes.colorThemeRegistry.remove(be),this.ctx.managers.lociLabels.removeProvider(this.labelProvider),this.ctx.query.structure.registry.remove(Pe),this.ctx.query.structure.registry.remove(Ee)},t}(u.a.Handler),params:function(){return{autoAttach:P.ParamDefinition.Boolean(!1),showTooltip:P.ParamDefinition.Boolean(!0)}}});function we(e){if("element-loci"===e.kind){if(0===e.elements.length)return;if(!(l=pe.get(e.structure).value)||e.structure.customPropertyDescriptors.hasReference(pe.descriptor))return;for(var t=e.structure.root.serialMapping.getSerialIndex,r=l.area,n=l.serialResidueIndex,i=new Set,a=0,o=function(e,o){var s=o.elements;ye.OrderedSet.forEach(e,(function(e){var u=n[t(o,s[e])];-1===u||i.has(u)||(a+=r[u],i.add(u))}))},s=0,u=e.elements;s<u.length;s++){var c=u[s];o(c.indices,c.unit)}if(0===i.size)return;return"Accessible Surface Area "+("<small>("+i.size+" "+(i.size>1?"Residues sum":"Residue")+")</small>")+": "+a.toFixed(2)+" Å<sup>2</sup>"}if("structure-loci"===e.kind){var l;if(!(l=pe.get(e.structure).value)||e.structure.customPropertyDescriptors.hasReference(pe.descriptor))return;return"Accessible Surface Area <small>(Whole Structure)</small>: "+Object(_e.arraySum)(l.area).toFixed(2)+" Å<sup>2</sup>"}}var Ce,je,Pe=Object(Se.c)("Buried Protein 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pe.attach(e,t)}}),Ae=r(106),De=r(139),Te=r(264),Ie=r(338),Me=r(342),ke=u.a.create({name:"computed-interactions-prop",category:"custom-props",display:{name:"Interactions"},ctor:function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.provider=Ae.a,t.labelProvider={label:function(e){if(t.params.showTooltip)switch(e.kind){case"element-loci":if(0===e.elements.length)return;for(var r=[],n=0,i=t.getStructures(e.structure);n<i.length;n++){var a=i[n],o=t.provider.get(a).value;if(o){var s=De.a.Loci.remap(e,a);if(1===s.elements.length){var u=s.elements[0];if(1===ye.OrderedSet.size(u.indices)){var c=o.unitsFeatures.get(u.unit.id);if(c){for(var l=[],d=[],f=[],p=ye.OrderedSet.start(u.indices),m=c.types,h=c.groups,g=c.elementsIndex,v=g.indices,b=g.offsets,y=b[p],_=b[p+1];y<_;++y){var S=v[y],x=m[S],O=h[S];x&&l.push(Object(Te.d)(x)),O&&d.push(Object(Te.c)(O))}l.length&&f.push("<small>Types</small> "+l.join(", ")),d.length&&f.push("<small>Groups</small> "+d.join(", 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this.params.autoAttach=e.autoAttach,this.params.showTooltip=e.showTooltip,this.ctx.customStructureProperties.setDefaultAutoAttach(this.provider.descriptor.name,this.params.autoAttach),t},t.prototype.register=function(){this.ctx.customStructureProperties.register(this.provider,this.params.autoAttach),this.ctx.representation.structure.themes.colorThemeRegistry.add(Ie.a),this.ctx.managers.lociLabels.addProvider(this.labelProvider),this.ctx.representation.structure.registry.add(Me.a)},t.prototype.unregister=function(){this.ctx.customStructureProperties.unregister(this.provider.descriptor.name),this.ctx.representation.structure.themes.colorThemeRegistry.remove(Ie.a),this.ctx.managers.lociLabels.removeProvider(this.labelProvider),this.ctx.representation.structure.registry.remove(Me.a)},t}(u.a.Handler),params:function(){return{autoAttach:P.ParamDefinition.Boolean(!1),showTooltip:P.ParamDefinition.Boolean(!0)}}}),Be=r(181),Ve=u.a.create({name:"computed-secondary-structure-prop",category:"custom-props",display:{name:"Secondary Structure"},ctor:function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.provider=Be.a,t}return Object(C.__extends)(t,e),t.prototype.update=function(e){var t=this.params.autoAttach!==e.autoAttach;return this.params.autoAttach=e.autoAttach,this.ctx.customStructureProperties.setDefaultAutoAttach(this.provider.descriptor.name,this.params.autoAttach),t},t.prototype.register=function(){this.ctx.customStructureProperties.register(this.provider,this.params.autoAttach)},t.prototype.unregister=function(){this.ctx.customStructureProperties.unregister(this.provider.descriptor.name)},t}(u.a.Handler),params:function(){return{autoAttach:P.ParamDefinition.Boolean(!1)}}}),Re=r(239),Le=r(155),Ne=u.a.create({name:"computed-valence-model-prop",category:"custom-props",display:{name:"Valence Model"},ctor:function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.provider=Re.a,t.labelProvider={label:function(e){if(t.params.showTooltip)switch(e.kind){case"element-loci":if(0===e.elements.length)return;for(var r=[],n=0,i=t.getStructures(e.structure);n<i.length;n++){var a=i[n],o=t.provider.get(a).value;if(o){var s=B.StructureElement.Loci.remap(e,a);if(1===s.elements.length){var u=s.elements[0];if(1===ye.OrderedSet.size(u.indices)){var c=o.get(u.unit.id);if(c){var l=ye.OrderedSet.start(u.indices),d=c.charge[l],f=c.idealGeometry[l],p=c.implicitH[l],m=c.totalH[l];r.push("Valence Model: <small>Charge</small> "+d+" | <small>Ideal Geometry</small> "+Object(Le.e)(f)+" | <small>Implicit H</small> "+p+" | <small>Total H</small> "+m)}}}}}return r.length?r.join("<br/>"):void 0;default:return}}},t}return Object(C.__extends)(t,e),t.prototype.getStructures=function(e){var t=[],r=this.ctx.helpers.substructureParent.get(e);if(r)for(var n=0,i=this.ctx.state.data.select(V.StateSelection.Generators.ofType(l.a.Molecule.Structure,r.transform.ref));n<i.length;n++){var a=i[n];a.obj&&Object(_e.arraySetAdd)(t,a.obj.data)}return t},t.prototype.update=function(e){var t=this.params.autoAttach!==e.autoAttach||this.params.showTooltip!==e.showTooltip;return this.params.autoAttach=e.autoAttach,this.params.showTooltip=e.showTooltip,this.ctx.customStructureProperties.setDefaultAutoAttach(this.provider.descriptor.name,this.params.autoAttach),t},t.prototype.register=function(){this.ctx.customStructureProperties.register(this.provider,this.params.autoAttach),this.ctx.managers.lociLabels.addProvider(this.labelProvider)},t.prototype.unregister=function(){this.ctx.customStructureProperties.unregister(this.provider.descriptor.name),this.ctx.managers.lociLabels.removeProvider(this.labelProvider)},t}(u.a.Handler),params:function(){return{autoAttach:P.ParamDefinition.Boolean(!1),showTooltip:P.ParamDefinition.Boolean(!0)}}}),Fe=r(157);(je=Ce||(Ce={})).Descriptor={name:"ihm_cross_link_restraint"},je.Provider=Fe.a.create(je.Descriptor),je.fromTable=function(e,t){var r={entity_id:e.entity_id_1,asym_id:e.asym_id_1,seq_id:e.seq_id_1,atom_id:e.atom_id_1},n={entity_id:e.entity_id_2,asym_id:e.asym_id_2,seq_id:e.seq_id_2,atom_id:e.atom_id_2};function i(e,t,r){var n=e.get(t);n?n.push(r):e.set(t,[r])}function a(r,n){var a=n.entity_id.value(r),c=n.asym_id.value(r),l=n.seq_id.value(r);if("by-atom"===e.model_granularity.value(r)){var d=t.atomicHierarchy.index.findAtom({auth_seq_id:l,label_asym_id:c,label_atom_id:n.atom_id.value(r),label_entity_id:a});d>=0&&i(o,d,r)}else if(t.coarseHierarchy.isDefined){var f=t.coarseHierarchy.spheres.findSequenceKey(a,c,l);if(f>=0)i(s,f,r);else{var p=t.coarseHierarchy.gaussians.findSequenceKey(a,c,l);p>=0&&i(u,p,r)}}}for(var o=new Map,s=new Map,u=new Map,c=[],l=0;l<e._rowCount;++l)a(l,r),a(l,n);return{getIndicesByElement:function(e,t){var r=function(e){switch(e){case 0:return o;case 1:return s;case 2:return u}}(t).get(e);return void 0!==r?r:c},data:e}};var Ue=r(74),ze=r(41),He=r(38),Ge=r(53),qe=r(112),We=r(92),Xe=r(55),Ye=[];function Qe(e,t,r,n){return e+"|"+t.id+"|"+r+"|"+n.id}var Ke,Ze=function(){function e(e){this.pairs=e;var t=new Map;this.pairs.forEach((function(e,r){var n=Qe(e.indexA,e.unitA,e.indexB,e.unitB),i=t.get(n);i?i.push(r):t.set(n,[r])})),this.count=e.length,this.pairKeyIndices=t}return e.prototype.getPairIndices=function(e,t,r,n){var i=Qe(e,t,r,n);return this.pairKeyIndices.get(i)||Ye},e.prototype.getPairs=function(e,t,r,n){var i=this;return this.getPairIndices(e,t,r,n).map((function(e){return i.pairs[e]}))},e}(),Je=r(117),$e=r(201),et=r(77),tt=oe.a.createProvider({label:"Cross Link Restraint",descriptor:Object(le.CustomPropertyDescriptor)({name:"integrative-cross-link-restraint"}),type:"local",defaultParams:{},getParams:function(e){return{}},isApplicable:function(e){return e.models.some((function(e){return!!Ce.Provider.get(e)}))},obtain:function(e,t,r){return Object(C.__awaiter)(void 0,void 0,void 0,(function(){return Object(C.__generator)(this,(function(e){return[2,{value:ot(t)}]}))}))}});function rt(e,t,r){for(var n=t.elements,i=n.length,a=t.kind,o=function(t){var i=n[t];r.getIndicesByElement(i,a).forEach((function(r){return e.set(r,t)}))},s=0;s<i;s++)o(s)}function nt(e,t,r){if(t.model===r.model&&"mmCIF"===t.model.sourceData.kind){var n=Ce.Provider.get(t.model);if(n){var i=new Map,a=new Map;rt(i,t,n),rt(a,r,n),i.forEach((function(i,o){var s=a.get(o);void 0!==s&&e.push(at(t,i,r,s,n,o),at(r,s,t,i,n,o))}))}}}function it(e,t){if("mmCIF"===t.model.sourceData.kind){var r=Ce.Provider.get(t.model);if(r){for(var n=t.elements,i=n.length,a=t.kind,o=new Map,s=function(e){var t=n[e];r.getIndicesByElement(t,a).forEach((function(t){var r=o.get(t);r?r.push(e):o.set(t,[e])}))},u=0;u<i;u++)s(u);o.forEach((function(n,i){if(!(n.length<2)){var a=n[0],o=n[1];e.push(at(t,a,t,o,r,i),at(t,o,t,a,r,i))}}))}}}function at(e,t,r,n,i,a){return{unitA:e,indexA:t,unitB:r,indexB:n,restraintType:i.data.restraint_type.value(a),distanceThreshold:i.data.distance_threshold.value(a),psi:i.data.psi.value(a),sigma1:i.data.sigma_1.value(a),sigma2:i.data.sigma_2.value(a)}}function ot(e){var t=[];if(!e.models.some((function(e){return Ce.Provider.get(e)})))return new Ze(t);for(var r=e.units.length,n=0;n<r;++n){var i=e.units[n];it(t,i);for(var a=n+1;a<r;++a){var o=e.units[a];i.model===o.model&&nt(t,i,o)}}return new Ze(t)}function st(e,t,r,n,i){var a=tt.get(t).value;if(!a.count)return He.a.createEmpty(i);var o=n.sizeFactor,s=B.StructureElement.Location.create(t),u={linkCount:a.count,position:function(e,t,r){var n=a.pairs[r],i=n.unitA,o=n.unitB;i.conformation.position(i.elements[n.indexA],e),o.conformation.position(o.elements[n.indexB],t)},radius:function(e){var t=a.pairs[e];return s.unit=t.unitA,s.element=t.unitA.elements[t.indexA],r.size.size(s)*o}};return Object(qe.d)(e,u,n,i)}!function(e){!function(e){e.CrossLinkRestraint="cross-link-restraint"}(e.Tag||(e.Tag={})),e.isApplicable=function(e){return e.models.some((function(e){return!!Ce.Provider.get(e)}))};var t=Object(N.Vec3)(),r=Object(N.Vec3)();function n(e){return e.unitA.conformation.position(e.unitA.elements[e.indexA],t),e.unitB.conformation.position(e.unitB.elements[e.indexB],r),N.Vec3.distance(t,r)}function i(e,t){var r=e.pairs[t];return"Cross Link Restraint | Type: "+r.restraintType+" | Threshold: "+r.distanceThreshold+" Å | Psi: "+r.psi+" | Sigma 1: "+r.sigma1+" | Sigma 2: "+r.sigma2+" | Distance: "+n(r).toFixed(2)+" Å"}function a(e,t,r){return $e.a.fromPairProvider(t.length,(function(r,n,i){var a=e.pairs[t[r]];a.unitA.conformation.position(a.unitA.elements[a.indexA],n),a.unitB.conformation.position(a.unitB.elements[a.indexB],i)}),r)}function o(e,t,r){var n=r[0];if(void 0===n)return"";var 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D};return{factory:e,granularity:"group",color:n,props:r,description:"Gives every polymer chain a color based on its `asym_id` value.",legend:a}},getParams:function(e){var t=o.ParamDefinition.clone(T);return e.structure&&M(e.structure.root).size>A.ColorLists["dark-2"].list.length&&(t.palette.defaultValue.name="colors",t.palette.defaultValue.params=Object(h.__assign)(Object(h.__assign)({},t.palette.defaultValue.params),{list:{kind:"interpolate",colors:Object(A.getColorListFromName)("dark-2").list}})),t},defaultValues:o.ParamDefinition.getDefaultValues(T),isApplicable:function(e){return!!e.structure}},B=Object(n.Color)(13421772),V=Object(h.__assign)({},Object(v.b)({type:"colors",colorList:"dark-2"}));function R(e){for(var t=0,r=e.units,n=0,i=r.length;n<i;++n)r[n].polymerElements.length>0&&++t;return t}var L={name:"polymer-index",label:"Polymer Chain Instance",category:"Chain Property",factory:function e(t,r){var n,a;if(t.structure){var o=Object(v.a)(R(t.structure.root),r);a=o.legend;for(var s=t.structure.root.units,u=new Map,c=0,l=0,d=s.length;c<d;++c)s[c].polymerElements.length>0&&(u.set(s[c].id,o.color(l)),++l);n=function(e){var t;return i.StructureElement.Location.is(e)?t=u.get(e.unit.id):i.Bond.isLocation(e)&&(t=u.get(e.aUnit.id)),void 0!==t?t:B}}else n=function(){return B};return{factory:e,granularity:"instance",color:n,props:r,description:"Gives every polymer chain instance a unique color based on the position (index) of the polymer in the list of polymers in the structure.",legend:a}},getParams:function(e){var t=o.ParamDefinition.clone(V);return e.structure&&R(e.structure.root)>A.ColorLists["dark-2"].list.length&&(t.palette.defaultValue.name="colors",t.palette.defaultValue.params=Object(h.__assign)(Object(h.__assign)({},t.palette.defaultValue.params),{list:{kind:"interpolate",colors:Object(A.getColorListFromName)("dark-2").list}})),t},defaultValues:o.ParamDefinition.getDefaultValues(V),isApplicable:function(e){return!!e.structure}},N=Object(n.ColorMap)({ALA:9240460,ARG:124,ASN:16743536,ASP:10485826,CYS:16777072,GLN:16731212,GLU:6684672,GLY:15658734,HIS:7368959,ILE:19456,LEU:4546117,LYS:4671416,MET:12099650,PHE:5459026,PRO:5395026,SER:16740418,THR:12078080,TRP:5195264,TYR:9203788,VAL:16747775,A:14423100,G:3329330,I:10145074,C:16766720,T:4286945,U:4251856,DA:14423100,DG:3329330,DI:10145074,DC:16766720,DT:4286945,DU:4251856,APN:14423100,GPN:3329330,CPN:16766720,TPN:4286945}),F=Object(n.Color)(16711935),U={saturation:o.ParamDefinition.Numeric(0,{min:-6,max:6,step:.1}),lightness:o.ParamDefinition.Numeric(1,{min:-6,max:6,step:.1})};function z(e,t){return e.model.atomicHierarchy.atoms.label_comp_id.value(t)}function H(e,t){var r=e.coarseElements.seq_id_begin.value(t);if(r===e.coarseElements.seq_id_end.value(t)){var n=e.coarseElements.entityKey[t];return e.model.sequence.byEntityKey[n].sequence.compId.value(r-1)}}function G(e,t){var r=e[t];return void 0===r?F:r}var q={name:"residue-name",label:"Residue Name",category:"Residue Property",factory:function e(t,r){var n=Object(O.getAdjustedColorMap)(N,r.saturation,r.lightness);return{factory:e,granularity:"group",color:function(e){if(i.StructureElement.Location.is(e)){if(i.Unit.isAtomic(e.unit)){var t=z(e.unit,e.element);return G(n,t)}if(t=H(e.unit,e.element))return G(n,t)}else if(i.Bond.isLocation(e)){if(i.Unit.isAtomic(e.aUnit)){t=z(e.aUnit,e.aUnit.elements[e.aIndex]);return G(n,t)}if(t=H(e.aUnit,e.aUnit.elements[e.aIndex]))return G(n,t)}return F},props:r,description:"Assigns a color to every residue according to its name.",legend:Object(s.b)(Object.keys(N).map((function(e){return[e,N[e]]})).concat([["Unknown",F]]))}},getParams:function(e){return U},defaultValues:o.ParamDefinition.getDefaultValues(U),isApplicable:function(e){return!!e.structure}},W=r(22),X=r(181),Y=r(12),Q=Object(n.ColorMap)({alphaHelix:16711808,threeTenHelix:10485888,piHelix:6291584,betaTurn:6324479,betaStrand:16762880,coil:16777215,bend:6740169,turn:45670,dna:11403518,rna:16580962,carbohydrate:10921722}),K=Object(n.Color)(8421504),Z={saturation:o.ParamDefinition.Numeric(-1,{min:-6,max:6,step:.1}),lightness:o.ParamDefinition.Numeric(0,{min:-6,max:6,step:.1})};function J(e,t,r,n){var a=W.SecondaryStructureType.create(0);if(n&&i.Unit.isAtomic(t)){var o=n.get(t.invariantId);o&&(a=o.type[o.getIndex(t.residueIndex[r])])}if(W.SecondaryStructureType.is(a,2))return W.SecondaryStructureType.is(a,2048)?e.threeTenHelix:W.SecondaryStructureType.is(a,32768)?e.piHelix:e.alphaHelix;if(W.SecondaryStructureType.is(a,4))return e.betaStrand;if(W.SecondaryStructureType.is(a,8))return e.bend;if(W.SecondaryStructureType.is(a,16))return e.turn;var s=Object(x.b)(t,r);return 7===s?e.dna:6===s?e.rna:9===s?e.carbohydrate:5===s?e.coil:K}var $={name:"secondary-structure",label:"Secondary Structure",category:"Residue Property",factory:function e(t,r){var n=t.structure&&X.a.get(t.structure),a=n?Object(Y.i)(n.id,n.version):-1,o=Object(O.getAdjustedColorMap)(Q,r.saturation,r.lightness);return{factory:e,granularity:"group",color:function(e){return i.StructureElement.Location.is(e)?J(o,e.unit,e.element,null==n?void 0:n.value):i.Bond.isLocation(e)?J(o,e.aUnit,e.aUnit.elements[e.aIndex],null==n?void 0:n.value):K},props:r,contextHash:a,description:"Assigns a color based on the type of secondary structure and basic molecule type.",legend:Object(s.b)(Object.keys(Q).map((function(e){return[e,Q[e]]})).concat([["Other",K]]))}},getParams:function(e){return Z},defaultValues:o.ParamDefinition.getDefaultValues(Z),isApplicable:function(e){return!!e.structure},ensureCustomProperties:{attach:function(e,t){return t.structure?X.a.attach(e,t.structure,void 0,!0):Promise.resolve()},detach:function(e){return e.structure&&e.structure.customPropertyDescriptors.reference(X.a.descriptor,!1)}}},ee=Object(n.Color)(13421772),te={list:o.ParamDefinition.ColorList("turbo",{presetKind:"scale"})};function re(e,t){var r=e.model;switch(e.kind){case 0:var n=r.atomicHierarchy.residueAtomSegments.index[t];return r.atomicHierarchy.residues.label_seq_id.value(n);case 1:return Math.round((r.coarseHierarchy.spheres.seq_id_begin.value(t)+r.coarseHierarchy.spheres.seq_id_end.value(t))/2);case 2:return Math.round((r.coarseHierarchy.gaussians.seq_id_begin.value(t)+r.coarseHierarchy.gaussians.seq_id_end.value(t))/2)}}function ne(e,t){var r=e.model,n="";switch(e.kind){case 0:var i=r.atomicHierarchy.chainAtomSegments.index[t];n=r.atomicHierarchy.chains.label_entity_id.value(i);break;case 1:n=r.coarseHierarchy.spheres.entity_id.value(t);break;case 2:n=r.coarseHierarchy.gaussians.entity_id.value(t)}if(""===n)return 0;var a=r.entities.getEntityIndex(n);if(-1===a)return 0;var o=r.sequence.byEntityKey[a];return void 0===o?0:o.sequence.length}var ie={name:"sequence-id",label:"Sequence Id",category:"Residue Property",factory:function e(t,r){var a=n.ColorScale.create({listOrName:r.list.colors,minLabel:"Start",maxLabel:"End"});return{factory:e,granularity:"group",color:function(e){if(i.StructureElement.Location.is(e)){var t=e.unit,r=e.element;if((n=re(t,r))>0)if(o=ne(t,r))return a.setDomain(0,o-1),a.color(n)}else if(i.Bond.isLocation(e)){var n,o,s=e.aUnit,u=e.aIndex;if((n=re(s,s.elements[u]))>0)if(o=ne(s,s.elements[u]))return a.setDomain(0,o-1),a.color(n)}return ee},props:r,description:"Gives every polymer residue a color based on its `seq_id` value.",legend:a?a.legend:void 0}},getParams:function(e){return te},defaultValues:o.ParamDefinition.getDefaultValues(te),isApplicable:function(e){return!!e.structure}},ae=r(370),oe=Object(n.Color)(13421772),se=Object(h.__assign)({},Object(v.b)({type:"colors",colorList:"dark-2"}));var ue={name:"unit-index",label:"Chain Instance",category:"Chain Property",factory:function e(t,r){var n,a;if(t.structure){var o=t.structure.root.units,s=Object(v.a)(o.length,r);a=s.legend;for(var u=new Map,c=0,l=o.length;c<l;++c)u.set(o[c].id,s.color(c));n=function(e){return i.StructureElement.Location.is(e)?u.get(e.unit.id):i.Bond.isLocation(e)?u.get(e.aUnit.id):oe}}else n=function(){return oe};return{factory:e,granularity:"instance",color:n,props:r,description:"Gives every chain instance (single chain or collection of single elements) a unique color based on the position (index) of the chain in the list of chains in the structure.",legend:a}},getParams:function(e){var t=o.ParamDefinition.clone(se);return e.structure&&e.structure.root.units.length>A.ColorLists["dark-2"].list.length&&(t.palette.defaultValue.name="colors",t.palette.defaultValue.params=Object(h.__assign)(Object(h.__assign)({},t.palette.defaultValue.params),{list:{kind:"interpolate",colors:Object(A.getColorListFromName)("dark-2").list}})),t},defaultValues:o.ParamDefinition.getDefaultValues(se),isApplicable:function(e){return!!e.structure}},ce=Object(n.Color)(16777113),le={domain:o.ParamDefinition.Interval([0,100]),list:o.ParamDefinition.ColorList("red-white-blue",{presetKind:"scale"})};function de(e,t){return i.Unit.isAtomic(e)?e.model.atomicConformation.B_iso_or_equiv.value(t):i.Unit.isSpheres(e)?e.model.coarseConformation.spheres.rmsf[t]:0}var fe={name:"uncertainty",label:"Uncertainty/Disorder",category:"Atom Property",factory:function e(t,r){var a=n.ColorScale.create({reverse:!0,domain:r.domain,listOrName:r.list.colors});return{factory:e,granularity:"group",color:function(e){return i.StructureElement.Location.is(e)?a.color(de(e.unit,e.element)):i.Bond.isLocation(e)?a.color(de(e.aUnit,e.aUnit.elements[e.aIndex])):ce},props:r,description:"Assigns a color based on the uncertainty or disorder of an element's position, e.g. B-factor or RMSF, depending on the data availability and experimental technique.",legend:a?a.legend:void 0}},getParams:function(e){return le},defaultValues:o.ParamDefinition.getDefaultValues(le),isApplicable:function(e){return!!e.structure&&e.structure.models.some((function(e){return e.atomicConformation.B_iso_or_equiv.isDefined||e.coarseHierarchy.isDefined}))}},pe=r(179),me=r(74),he=Object(n.Color)(16448250),ge=Object(h.__assign)({},Object(v.b)({type:"colors",colorList:"dark-2"}));function ve(e,t){return e+"|"+t}function be(e,t,r,n,i,a){return e+"|"+t+"|"+r+"|"+(a||(i||n))}function ye(e,t,r,n,i,a,o,s){for(var u=i.entity_id,c=i.pdbx_src_id,l=i.pdbx_beg_seq_num,d=i.pdbx_end_seq_num,f=0,p=i._rowCount;f<p;++f){var m=u.value(f),h=ve(r,m),g=void 0;if(e.has(h))g=e.get(h);else{var v=n.entities.getEntityIndex(m),b=n.sequence.sequences[v].sequence;g=new Int16Array(b.length),e.set(h,g)}var y=o?o.value(f):"",_=s?s.value(f)[0]:"",S=be(r,m,a.value(f),c.value(f),y,_),x=0===l.valueKind(f)?l.value(f):1,O=0===d.valueKind(f)?d.value(f):g.length,w=void 0;t.has(S)?w=t.get(S):(w=t.size+1,t.set(S,w));for(var C=x,j=O;C<=j;++C)g[C-1]=w}}function _e(e){for(var t=new Map,r=new Map,n=0,i=e.length;n<i;++n){var a=e[n];if(me.a.is(a.sourceData)){var o=a.sourceData.data.db,s=o.entity_src_gen,u=o.entity_src_nat,c=o.pdbx_entity_src_syn;ye(t,r,n,a,s,s.pdbx_gene_src_scientific_name,s.plasmid_name,s.pdbx_gene_src_gene),ye(t,r,n,a,u,u.pdbx_organism_scientific,u.pdbx_plasmid_name),ye(t,r,n,a,c,c.organism_scientific)}}return{seqToSrcByModelEntity:t,srcKeySerialMap:r}}var Se={name:"entity-source",label:"Entity Source",category:"Chain Property",factory:function e(t,r){var n,a;if(t.structure){var o=i.StructureElement.Location.create(t.structure),s=t.structure.root.models,u=_e(s),c=u.seqToSrcByModelEntity,l=u.srcKeySerialMap,d=function(e){var t=0;return Array.from(e.keys()).map((function(e){var r=e.split("|"),n=r[2];return(Object(pe.d)(r[3])?"Unnamed "+ ++t:r[3])+(n?" ("+n+")":"")}))}(l),f=Object(v.a)(l.size,r,{valueLabel:function(e){return d[e]}});a=f.legend;var p=function(e){var t=ve(s.indexOf(e.unit.model),i.StructureProperties.entity.id(e)),r=c.get(t);return r?f.color(r[i.StructureProperties.residue.label_seq_id(e)-1]-1):he};n=function(e){return i.StructureElement.Location.is(e)?p(e):i.Bond.isLocation(e)?(o.unit=e.aUnit,o.element=e.aUnit.elements[e.aIndex],p(o)):he}}else n=function(){return he};return{factory:e,granularity:"group",color:n,props:r,description:"Gives ranges of a polymer chain a color based on the entity source it originates from (e.g. gene, plasmid, organism).",legend:a}},getParams:function(e){var t=o.ParamDefinition.clone(ge);return e.structure&&_e(e.structure.root.models).srcKeySerialMap.size>A.ColorLists["dark-2"].list.length&&(t.palette.defaultValue.name="colors",t.palette.defaultValue.params=Object(h.__assign)(Object(h.__assign)({},t.palette.defaultValue.params),{list:{kind:"interpolate",colors:Object(A.getColorListFromName)("dark-2").list}})),t},defaultValues:o.ParamDefinition.getDefaultValues(ge),isApplicable:function(e){return!!e.structure}},xe=Object(n.Color)(15658734),Oe=Object(h.__assign)({},m.b);var we={name:"illustrative",label:"Illustrative",category:"Miscellaneous",factory:function e(t,r){var a=Object(m.a)(t,r),o=a.color;function s(e,t){var r=o(e,!1);return"C"===t?n.Color.lighten(r,.8):r}return{factory:e,granularity:"group",color:function(e){if(i.StructureElement.Location.is(e)&&i.Unit.isAtomic(e.unit)){var t=e.unit.model.atomicHierarchy.atoms.type_symbol.value(e.element);return s(e,t)}if(i.Bond.isLocation(e)&&i.Unit.isAtomic(e.aUnit)){var r=e.aUnit.elements[e.aIndex];t=e.aUnit.model.atomicHierarchy.atoms.type_symbol.value(r);return s(e,t)}return xe},props:r,description:"Assigns an illustrative color that gives every chain a unique color with lighter carbons (inspired by David Goodsell's Molecule of the Month style).",legend:a.legend}},getParams:function(e){return Oe},defaultValues:o.ParamDefinition.getDefaultValues(Oe),isApplicable:function(e){return!!e.structure}},Ce={list:o.ParamDefinition.ColorList("red-yellow-green",{presetKind:"scale"}),scale:o.ParamDefinition.Select("DGwif",[["DGwif","DG water-membrane"],["DGwoct","DG water-octanol"],["Oct-IF","DG difference"]])};var je={DGwif:0,DGwoct:1,"Oct-IF":2};function Pe(e,t){return e.model.atomicHierarchy.atoms.label_comp_id.value(t)}function Ee(e,t){var r=e.coarseElements.seq_id_begin.value(t);if(r===e.coarseElements.seq_id_end.value(t)){var n=e.coarseElements.entityKey[t];return e.model.sequence.byEntityKey[n].sequence.compId.value(r-1)}}var Ae={name:"hydrophobicity",label:"Hydrophobicity",category:"Residue Property",factory:function e(t,r){var a=je[r.scale],o=1/0,s=-1/0;for(var u in W.ResidueHydrophobicity){var c=W.ResidueHydrophobicity[u][a];o=Math.min(o,c),s=Math.max(s,c)}var l=n.ColorScale.create({listOrName:r.list.colors,domain:[s,o],minLabel:"Hydrophobic",maxLabel:"Hydrophilic"});return{factory:e,granularity:"group",color:function(e){var t;return i.StructureElement.Location.is(e)?t=i.Unit.isAtomic(e.unit)?Pe(e.unit,e.element):Ee(e.unit,e.element):i.Bond.isLocation(e)&&(t=i.Unit.isAtomic(e.aUnit)?Pe(e.aUnit,e.aUnit.elements[e.aIndex]):Ee(e.aUnit,e.aUnit.elements[e.aIndex])),l.color(t?function(e,t){var r=W.ResidueHydrophobicity[e];return void 0===r?0:r[t]}(t,a):0)},props:r,description:'Assigns a color to every amino acid according to the "Experimentally determined hydrophobicity scale for proteins at membrane interfaces" by Wimely and White (doi:10.1038/nsb1096-842).',legend:l?l.legend:void 0}},getParams:function(e){return Ce},defaultValues:o.ParamDefinition.getDefaultValues(Ce),isApplicable:function(e){return!!e.structure}},De=Object(n.Color)(13421772),Te=Object(h.__assign)({},Object(v.b)({type:"colors",colorList:"purples"}));var Ie={name:"model-index",label:"Model Index",category:"Chain Property",factory:function e(t,r){var n,a,o,s;if(t.structure){for(var u=t.structure.root.models,c=0,l=0,d=u;l<d.length;l++){var f=d[l];c=Math.max(c,(null===(n=i.Model.TrajectoryInfo.get(f))||void 0===n?void 0:n.size)||0)}var p=Object(v.a)(c,r);s=p.legend;for(var m=new Map,h=0,g=u.length;h<g;++h){var b=(null===(a=i.Model.TrajectoryInfo.get(u[h]))||void 0===a?void 0:a.index)||0;m.set(b,p.color(b))}o=function(e){return i.StructureElement.Location.is(e)?m.get(i.Model.TrajectoryInfo.get(e.unit.model).index):i.Bond.isLocation(e)?m.get(i.Model.TrajectoryInfo.get(e.aUnit.model).index):De}}else o=function(){return De};return{factory:e,granularity:"instance",color:o,props:r,description:"Gives 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0===this._isIdentity){this._isIdentity=!0;for(var e=0,t=16*this.size;e<t;e+=16)if(E.Mat4.fromArray(D,this.unitTransforms,e),!E.Mat4.isIdentity(D)){this._isIdentity=!1;break}}return this._isIdentity},enumerable:!1,configurable:!0}),e.prototype.setTransform=function(e,t){this.version=(this.version+1)%2147483647,E.Mat4.toArray(e,this.unitTransforms,this.unitOffsetMap.get(t.id)),this._isIdentity=void 0},e.prototype.getTransform=function(e,t){return E.Mat4.fromArray(e,this.unitTransforms,this.unitOffsetMap.get(t.id))},e.prototype.getSymmetryGroupTransforms=function(e){return this.groupUnitTransforms[this.groupIndexMap.get(e.hashCode)]},e}(),I=r(9),M=E.Mat4.zero();function k(e,t,r){for(var n=0,i=e.units.length;n<i;n++){var a=e.units[n];I.h.lerpFromIdentity(M,a.conformation.operator,r),t.setTransform(M,a)}}var B=E.Vec3.zero(),V=E.Vec3.zero(),R=E.Mat4.zero();function L(e,t,r){for(var n=e.boundary.sphere,i=n.radius*r,a=0,o=e.units.length;a<o;a++){var s=e.units[a];E.Vec3.transformMat4(B,s.lookup3d.boundary.sphere.center,s.conformation.operator.matrix),E.Vec3.sub(V,B,n.center),E.Vec3.setMagnitude(V,V,i),E.Mat4.fromTranslation(R,V),t.setTransform(R,s)}}var N=r(24),F=r(140),U=r(141),z=r(30),H=r(126),G=r(38),q=r(35),W=r(256),X=r(190),Y=E.Mat4.fromTranslation(Object(E.Mat4)(),E.Vec3.create(.5,.5,.5)),Q=Object(X.c)(Object(X.a)(Object(W.b)()),Y),K=Object(E.Vec3)(),Z=Object(E.Mat4)(),J=Object(n.__assign)(Object(n.__assign)({},G.a.Params),{cellColor:c.ParamDefinition.Color(d.a.orange),cellScale:c.ParamDefinition.Numeric(2,{min:.1,max:5,step:.1}),ref:c.ParamDefinition.Select("model",c.ParamDefinition.objectToOptions({origin:"Origin",model:"Model"}),{isEssential:!0}),attachment:c.ParamDefinition.Select("corner",c.ParamDefinition.objectToOptions({corner:"Corner",center:"Center"}),{isEssential:!0})}),$={mesh:function(e,t){return P(te,G.a.Utils)}},ee=Object(n.__assign)({},J);function te(e,t,r,n){var a=function(e,t,r){var n=q.a.createState(256,128,r),i=e.symmetry.spacegroup.cell.fromFractional;E.Vec3.copy(K,e.ref),"center"===t.attachment?(E.Vec3.trunc(K,K),E.Vec3.subScalar(K,K,.5)):E.Vec3.floor(K,K),E.Mat4.fromTranslation(Z,K);var a=Object(X.c)(Object(X.a)(Q),Z),o=Math.cbrt(e.symmetry.spacegroup.cell.volume)/300*t.cellScale;n.currentGroup=1,q.a.addCage(n,i,a,o,2,20);var s=I.g.fromDimensionsAndTransform(Object(I.g)(),E.Vec3.unit,i);E.Vec3.transformMat4(K,K,i),I.g.translate(s,s,K),I.g.expand(s,s,o);var u=q.a.getMesh(n);return u.setBoundingSphere(s),u}(t,r,n&&n.geometry),o=i.Symmetry.getUnitcellLabel(t.symmetry);return m.a.create(o,t,a,(function(){return r.cellColor}),(function(){return 1}),(function(){return o}))}function re(e,t,r){var n=Object(E.Vec3)();return"model"===r.ref&&E.Vec3.transformMat4(n,i.Model.getCenter(e),t.spacegroup.cell.toFractional),{symmetry:t,ref:n}}var ne=r(80),ie=r(144),ae=r(170),oe=r(216),se=r(77),ue=r(232),ce={unitLabel:c.ParamDefinition.Text("Å",{isEssential:!0})},le=Object(n.__assign)(Object(n.__assign)(Object(n.__assign)({},ne.a.Params),ce),{lineSizeAttenuation:c.ParamDefinition.Boolean(!0),linesColor:c.ParamDefinition.Color(d.a.lightgreen,{isEssential:!0}),linesSize:c.ParamDefinition.Numeric(.075,{min:.01,max:5,step:.01}),dashLength:c.ParamDefinition.Numeric(.2,{min:.01,max:.2,step:.01})}),de=Object(n.__assign)(Object(n.__assign)({},ue.a),ce),fe={lines:function(e,t){return P(ve,ne.a.Utils,{modifyState:function(e){return Object(n.__assign)(Object(n.__assign)({},e),{markerActions:y.b.Highlighting})}})},text:function(e,t){return P(be,ie.a.Utils,{modifyState:function(e){return Object(n.__assign)(Object(n.__assign)({},e),{markerActions:y.a.None})}})}},pe=Object(n.__assign)(Object(n.__assign)(Object(n.__assign)({},le),de),{visuals:c.ParamDefinition.MultiSelect(["lines","text"],c.ParamDefinition.objectToOptions(fe))});function me(e,t){var r=t.sphereA,n=t.sphereB,i=t.center,a=e.loci,o=a[0],s=a[1];return O.Loci.getBoundingSphere(o,r),O.Loci.getBoundingSphere(s,n),E.Vec3.add(i,r.center,n.center),E.Vec3.scale(i,i,.5),t.distance=E.Vec3.distance(r.center,n.center),t}var he={sphereA:Object(I.g)(),sphereB:Object(I.g)(),center:Object(E.Vec3)(),distance:0};function ge(e,t){return 1===e.pairs.length?"Distance "+Object(se.distanceLabel)(e.pairs[0],{unitLabel:t,measureOnly:!0}):e.pairs.length+" Distances"}function ve(e,t,r,n){var i=function(e,t,r){for(var n=ae.a.create(128,64,r),i=0,a=e.pairs.length;i<a;++i)me(e.pairs[i],he),n.addFixedLengthDashes(he.sphereA.center,he.sphereB.center,t.dashLength,i);return n.getLines()}(t,r,n&&n.geometry),a=ge(t,r.unitLabel);return m.a.create(a,t,i,(function(){return r.linesColor}),(function(){return r.linesSize}),(function(e){return Object(se.distanceLabel)(t.pairs[e],r)}))}function be(e,t,r,n){var i=function(e,t,r){for(var n=oe.a.create(t,128,64,r),i=0,a=e.pairs.length;i<a;++i){me(e.pairs[i],he);var o=he.center,s=he.distance,u=he.sphereA,c=he.sphereB,l=t.customText||s.toFixed(2)+" "+t.unitLabel,d=Math.max(2,u.radius,c.radius)/2;n.add(l,o[0],o[1],o[2],1,d,i)}return n.getText()}(t,r,n&&n.geometry),a=ge(t,r.unitLabel);return m.a.create(a,t,i,(function(){return r.textColor}),(function(){return r.textSize}),(function(e){return Object(se.distanceLabel)(t.pairs[e],r)}))}function ye(e){return{pairs:[{loci:[e[0].loci,e[1].loci]}]}}function _e(e){return{triples:[{loci:[e[0].loci,e[1].loci,e[2].loci]}]}}function Se(e){return{quads:[{loci:[e[0].loci,e[1].loci,e[2].loci,e[3].loci]}]}}function xe(e){return{infos:[{loci:e[0].loci}]}}function Oe(e){return{locis:[e[0].loci]}}var we=Object(n.__assign)(Object(n.__assign)({},ue.a),{offsetZ:c.ParamDefinition.Numeric(2,{min:0,max:10,step:.1})}),Ce={text:function(e,t){return P(Ae,ie.a.Utils,{modifyState:function(e){return Object(n.__assign)(Object(n.__assign)({},e),{pickable:!1})}})}},je=Object(n.__assign)(Object(n.__assign)({},we),{scaleByRadius:c.ParamDefinition.Boolean(!0),visuals:c.ParamDefinition.MultiSelect(["text"],c.ParamDefinition.objectToOptions(Ce))}),Pe=Object(I.g)();function Ee(e,t){return void 0===t&&(t=!1),e.label||Object(se.lociLabel)(e.loci,{hidePrefix:!0,htmlStyling:!1,condensed:t})}function Ae(e,t,r,n){var i=function(e,t,r){for(var n=oe.a.create(t,128,64,r),i=t.customText.trim(),a=0,o=e.infos.length;a<o;++a){var s=e.infos[a],u=O.Loci.getBoundingSphere(s.loci,Pe);if(u){var c=u.center,l=u.radius,d=i||Ee(s,!0);n.add(d,c[0],c[1],c[2],t.scaleByRadius?l/.9:0,t.scaleByRadius?Math.max(1,l):1,a)}}return n.getText()}(t,r,n&&n.geometry),a=function(e){return 1===e.infos.length?Ee(e.infos[0]):e.infos.length+" Labels"}(t),o=r.customText.trim(),s=o?function(e){return o}:function(e){return Ee(t.infos[e])};return m.a.create(a,t,i,(function(){return r.textColor}),(function(){return r.textSize}),s)}var De=Object(E.Vec3)(),Te=E.Mat4.identity(),Ie=new Float32Array(18),Me=new Uint8Array([0,1,2,3,4,5]);function ke(e,t,r,n,i){var a=t.origin,o=t.dirA,s=t.dirB,u=t.dirC;E.Vec3.add(De,a,o),E.Vec3.toArray(E.Vec3.add(De,a,o),Ie,0),E.Vec3.toArray(E.Vec3.sub(De,a,o),Ie,3),E.Vec3.toArray(E.Vec3.add(De,a,s),Ie,6),E.Vec3.toArray(E.Vec3.sub(De,a,s),Ie,9),E.Vec3.toArray(E.Vec3.add(De,a,u),Ie,12),E.Vec3.toArray(E.Vec3.sub(De,a,u),Ie,15);var c=Object(X.b)(Ie,Me),l=I.a.volume(t),d=Math.cbrt(l)/300*r;q.a.addCage(e,Te,c,d,n,i)}r(91),r(82),E.Vec3.zero(),E.Vec3.zero();var Be=Object(E.Vec3)(),Ve=Object(E.Vec3)(),Re=Object(E.Vec3)(),Le=Object(E.Vec3)(),Ne=E.Mat4.identity(),Fe=new Float32Array(24),Ue=new Uint8Array([0,1,0,3,0,6,1,2,1,7,2,3,2,4,3,5,4,5,4,7,5,6,6,7]);function ze(e,t,r,n,i){var a=t.origin,o=t.dirA,s=t.dirB,u=t.dirC,c=E.Vec3.negate(Ve,o),l=E.Vec3.negate(Re,s),d=E.Vec3.negate(Le,u),f=0,p=function(e,t,r){E.Vec3.copy(Be,a),E.Vec3.add(Be,Be,e),E.Vec3.add(Be,Be,t),E.Vec3.add(Be,Be,r),E.Vec3.toArray(Be,Fe,f),f+=3};p(o,s,u),p(o,s,d),p(o,l,d),p(o,l,u),p(c,l,d),p(c,l,u),p(c,s,u),p(c,s,d);var m=Object(X.b)(Fe,Ue),h=I.a.volume(t),g=Math.cbrt(h)/300*r;q.a.addCage(e,Ne,m,g,n,i)}var He=r(317),Ge={color:c.ParamDefinition.Color(d.a.orange),scale:c.ParamDefinition.Numeric(2,{min:.1,max:10,step:.1})},qe=Object(n.__assign)(Object(n.__assign)({},G.a.Params),Ge),We=Object(n.__assign)(Object(n.__assign)({},G.a.Params),Ge),Xe=(Object(n.__assign)(Object(n.__assign)({},G.a.Params),Ge),{axes:function(e,t){return P(Ze,G.a.Utils)},box:function(e,t){return P(Je,G.a.Utils)},ellipsoid:function(e,t){return P($e,G.a.Utils)}}),Ye=Object(n.__assign)(Object(n.__assign)(Object(n.__assign)({},qe),We),{visuals:c.ParamDefinition.MultiSelect(["box"],c.ParamDefinition.objectToOptions(Xe)),color:c.ParamDefinition.Color(d.a.orange),scale:c.ParamDefinition.Numeric(2,{min:.1,max:5,step:.1})});function Qe(e){return"Principal Axes of "+Object(se.lociLabel)(e,{countsOnly:!0})}function Ke(e){return 1===e.locis.length?Qe(e.locis[0]):e.locis.length+" Orientations"}function Ze(e,t,r,n){var i=function(e,t,r){for(var n=q.a.createState(256,128,r),i=0,a=e.locis.length;i<a;++i){var o=O.Loci.getPrincipalAxes(e.locis[i]);o&&(n.currentGroup=i,ke(n,o.momentsAxes,t.scale,2,20))}return q.a.getMesh(n)}(t,r,n&&n.geometry),a=Ke(t);return m.a.create(a,t,i,(function(){return r.color}),(function(){return 1}),(function(e){return Qe(t.locis[e])}))}function Je(e,t,r,n){var i=function(e,t,r){for(var n=q.a.createState(256,128,r),i=0,a=e.locis.length;i<a;++i){var o=O.Loci.getPrincipalAxes(e.locis[i]);o&&(n.currentGroup=i,ze(n,o.boxAxes,t.scale,2,20))}return q.a.getMesh(n)}(t,r,n&&n.geometry),a=Ke(t);return m.a.create(a,t,i,(function(){return r.color}),(function(){return 1}),(function(e){return Qe(t.locis[e])}))}function $e(e,t,r,n){var i=function(e,t,r){for(var n=q.a.createState(256,128,r),i=0,a=e.locis.length;i<a;++i){var o=O.Loci.getPrincipalAxes(e.locis[i]);if(o){var s=o.boxAxes,u=s.origin,c=s.dirA,l=s.dirB,d=I.a.size(Object(E.Vec3)(),s);E.Vec3.scale(d,d,.5);var f=E.Vec3.create(d[2],d[1],d[0]);n.currentGroup=i,Object(He.a)(n,u,c,l,f,2)}}return q.a.getMesh(n)}(t,0,n&&n.geometry),a=Ke(t);return m.a.create(a,t,i,(function(){return r.color}),(function(){return 1}),(function(e){return Qe(t.locis[e])}))}var et=r(44),tt={radius:1,segments:36,thetaStart:0,thetaLength:2*Math.PI};function rt(e){var t=Object(n.__assign)(Object(n.__assign)({},tt),e),r=t.radius,i=t.segments,a=t.thetaStart,o=t.thetaLength,s=o===2*Math.PI,u=s?i+1:i+2,c=new Float32Array(3*u),l=new Float32Array(3*u),d=new Uint32Array(3*i);c[0]=0,c[1]=0,c[2]=0,l[0]=0,l[1]=1,l[2]=0;for(var f=0,p=3;f<i;++f,p+=3){var m=a+f/i*o;c[p]=r*Math.sin(m),c[p+1]=0,c[p+2]=r*Math.cos(m),l[p]=0,l[p+1]=1,l[p+2]=0}for(f=1,p=0;f<i;++f,p+=3)d[p]=f,d[p+1]=f+1,d[p+2]=0;if(s){d[h=3*(i-1)]=i,d[h+1]=1,d[h+2]=0}else{var h;m=a+o;c[p=3*(i+1)]=r*Math.sin(m),c[p+1]=0,c[p+2]=r*Math.cos(m),l[p]=0,l[p+1]=1,l[p+2]=0,d[h=3*(i-1)]=i,d[h+1]=i+1,d[h+2]=0}return{vertices:c,normals:l,indices:d}}var nt=r(137),it={color:c.ParamDefinition.Color(d.a.lightgreen),arcScale:c.ParamDefinition.Numeric(.7,{min:.01,max:1,step:.01})},at=Object(n.__assign)(Object(n.__assign)(Object(n.__assign)({},ne.a.Params),it),{lineSizeAttenuation:c.ParamDefinition.Boolean(!0),linesSize:c.ParamDefinition.Numeric(.04,{min:.01,max:5,step:.01}),dashLength:c.ParamDefinition.Numeric(.04,{min:.01,max:.2,step:.01})}),ot=Object(n.__assign)({},at),st=Object(n.__assign)({},at),ut=Object(n.__assign)(Object(n.__assign)(Object(n.__assign)({},G.a.Params),it),{ignoreLight:c.ParamDefinition.Boolean(!0),sectorOpacity:c.ParamDefinition.Numeric(.75,{min:0,max:1,step:.01})}),ct={vectors:function(e,t){return P(vt,ne.a.Utils,{modifyState:function(e){return Object(n.__assign)(Object(n.__assign)({},e),{pickable:!1})}})},arc:function(e,t){return P(bt,ne.a.Utils,{modifyState:function(e){return Object(n.__assign)(Object(n.__assign)({},e),{pickable:!1})}})},sector:function(e,t){return P(yt,G.a.Utils,{modifyProps:function(e){return Object(n.__assign)(Object(n.__assign)({},e),{alpha:e.sectorOpacity})},modifyState:function(e){return Object(n.__assign)(Object(n.__assign)({},e),{markerActions:y.b.Highlighting})}})},text:function(e,t){return P(_t,ie.a.Utils,{modifyState:function(e){return Object(n.__assign)(Object(n.__assign)({},e),{markerActions:y.a.None})}})}},lt=Object(n.__assign)(Object(n.__assign)(Object(n.__assign)(Object(n.__assign)(Object(n.__assign)({},ot),st),ut),ue.a),{visuals:c.ParamDefinition.MultiSelect(["vectors","sector","text"],c.ParamDefinition.objectToOptions(ct))});var dt=Object(E.Vec3)(),ft=Object(E.Mat4)();function pt(e,t,r){var n=t.sphereA,i=t.sphereB,a=t.sphereC,o=t.arcDirA,s=t.arcDirC,u=t.arcNormal,c=e.loci,l=c[0],d=c[1],f=c[2];O.Loci.getBoundingSphere(l,n),O.Loci.getBoundingSphere(d,i),O.Loci.getBoundingSphere(f,a),E.Vec3.sub(o,n.center,i.center),E.Vec3.sub(s,a.center,i.center),E.Vec3.cross(u,o,s);var p=Math.min(E.Vec3.magnitude(o),E.Vec3.magnitude(s))*r;return t.radius=p,t.angle=E.Vec3.angle(o,s),t}function mt(e,t){var r=e.radius,n=e.angle,i=t?Object(et.b)(n,r)/t:32;E.Mat4.targetTo(ft,e.sphereB.center,e.sphereA.center,e.arcNormal),E.Mat4.setTranslation(ft,e.sphereB.center),E.Mat4.mul(ft,ft,E.Mat4.rotY180);var a=rt({radius:r,thetaLength:n,segments:i});return Object(nt.c)(a,ft)}var ht={sphereA:Object(I.g)(),sphereB:Object(I.g)(),sphereC:Object(I.g)(),arcDirA:Object(E.Vec3)(),arcDirC:Object(E.Vec3)(),arcNormal:Object(E.Vec3)(),radius:0,angle:0};function gt(e){return 1===e.triples.length?"Angle "+Object(se.angleLabel)(e.triples[0],{measureOnly:!0}):e.triples.length+" Angles"}function vt(e,t,r,n){var i=function(e,t,r){for(var n=ae.a.create(128,64,r),i=0,a=e.triples.length;i<a;++i)pt(e.triples[i],ht,t.arcScale),n.addFixedLengthDashes(ht.sphereB.center,ht.sphereA.center,t.dashLength,i),n.addFixedLengthDashes(ht.sphereB.center,ht.sphereC.center,t.dashLength,i);return n.getLines()}(t,r,n&&n.geometry),a=gt(t);return m.a.create(a,t,i,(function(){return r.color}),(function(){return r.linesSize}),(function(){return""}))}function bt(e,t,r,n){var i=function(e,t,r){for(var n=ae.a.create(128,64,r),i=0,a=e.triples.length;i<a;++i){pt(e.triples[i],ht,t.arcScale);for(var o=mt(ht,t.dashLength),s=o.indices,u=o.vertices,c=0,l=s.length;c<l;c+=3)if(c%2!=1){var d=3*s[c],f=3*s[c+1],p=u[d],m=u[d+1],h=u[d+2],g=u[f],v=u[f+1],b=u[f+2];n.add(p,m,h,g,v,b,i)}}return n.getLines()}(t,r,n&&n.geometry),a=gt(t);return m.a.create(a,t,i,(function(){return r.color}),(function(){return r.linesSize}),(function(){return""}))}function yt(e,t,r,n){var i=function(e,t,r){for(var n=q.a.createState(128,64,r),i=0,a=e.triples.length;i<a;++i){pt(e.triples[i],ht,t.arcScale);var o=mt(ht);n.currentGroup=i,q.a.addPrimitive(n,E.Mat4.id,o),q.a.addPrimitiveFlipped(n,E.Mat4.id,o)}return q.a.getMesh(n)}(t,r,n&&n.geometry),a=gt(t);return m.a.create(a,t,i,(function(){return r.color}),(function(){return 1}),(function(e){return Object(se.angleLabel)(t.triples[e])}))}function _t(e,t,r,n){var i=function(e,t,r){for(var n=oe.a.create(t,128,64,r),i=0,a=e.triples.length;i<a;++i){pt(e.triples[i],ht,t.arcScale),E.Vec3.add(dt,ht.arcDirA,ht.arcDirC),E.Vec3.setMagnitude(dt,dt,ht.radius),E.Vec3.add(dt,ht.sphereB.center,dt);var o=Object(et.f)(ht.angle).toFixed(2),s=t.customText||o+"°",u=Math.max(2,ht.sphereA.radius,ht.sphereB.radius,ht.sphereC.radius)/2;n.add(s,dt[0],dt[1],dt[2],.1,u,i)}return n.getText()}(t,r,n&&n.geometry),a=gt(t);return m.a.create(a,t,i,(function(){return r.textColor}),(function(){return r.textSize}),(function(e){return Object(se.angleLabel)(t.triples[e])}))}var St={color:c.ParamDefinition.Color(d.a.lightgreen),arcScale:c.ParamDefinition.Numeric(.7,{min:.01,max:1,step:.01})},xt=Object(n.__assign)(Object(n.__assign)(Object(n.__assign)({},ne.a.Params),St),{lineSizeAttenuation:c.ParamDefinition.Boolean(!0),linesSize:c.ParamDefinition.Numeric(.04,{min:.01,max:5,step:.01}),dashLength:c.ParamDefinition.Numeric(.04,{min:.01,max:.2,step:.01})}),Ot=Object(n.__assign)({},xt),wt=Object(n.__assign)({},xt),Ct=Object(n.__assign)({},xt),jt=Object(n.__assign)({},xt),Pt=Object(n.__assign)(Object(n.__assign)(Object(n.__assign)({},G.a.Params),St),{ignoreLight:c.ParamDefinition.Boolean(!0),sectorOpacity:c.ParamDefinition.Numeric(.75,{min:0,max:1,step:.01})}),Et={vectors:function(e,t){return P(Vt,ne.a.Utils,{modifyState:function(e){return Object(n.__assign)(Object(n.__assign)({},e),{pickable:!1})}})},extenders:function(e,t){return P(Nt,ne.a.Utils,{modifyState:function(e){return 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n=t.sphereA,i=t.sphereB,a=t.sphereC,o=t.sphereD,s=t.dirBA,u=t.dirCD,c=t.projA,l=t.projD,d=t.arcPointA,f=t.arcPointD,p=t.arcDirA,m=t.arcDirD,h=t.arcCenter,g=t.arcNormal,v=e.loci,b=v[0],y=v[1],_=v[2],S=v[3];O.Loci.getBoundingSphere(b,n),O.Loci.getBoundingSphere(y,i),O.Loci.getBoundingSphere(_,a),O.Loci.getBoundingSphere(S,o),E.Vec3.add(h,i.center,a.center),E.Vec3.scale(h,h,.5),E.Vec3.sub(s,n.center,i.center),E.Vec3.sub(u,o.center,a.center),E.Vec3.add(d,h,s),E.Vec3.add(f,h,u),E.Vec3.sub(g,a.center,i.center),E.Vec3.orthogonalize(p,g,s),E.Vec3.orthogonalize(m,g,u),E.Vec3.projectPointOnVector(c,d,p,h),E.Vec3.projectPointOnVector(l,f,m,h);var x=Math.min(E.Vec3.distance(c,h),E.Vec3.distance(l,h))*r;E.Vec3.setMagnitude(p,p,x),E.Vec3.setMagnitude(m,m,x),E.Vec3.add(d,h,p),E.Vec3.add(f,h,m),t.radius=x,t.angle=E.Vec3.dihedralAngle(n.center,i.center,a.center,o.center),E.Vec3.matchDirection(Dt,g,E.Vec3.sub(Dt,d,n.center));var w=E.Vec3.angle(s,Dt),C=x/Math.cos(w-et.d);E.Vec3.add(c,i.center,E.Vec3.setMagnitude(Dt,s,C)),E.Vec3.matchDirection(Dt,g,E.Vec3.sub(Dt,f,o.center));var j=E.Vec3.angle(u,Dt),P=x/Math.cos(j-et.d);return E.Vec3.add(l,a.center,E.Vec3.setMagnitude(Dt,u,P)),t}function Mt(e,t){var r=e.radius,n=e.angle,i=t?Object(et.b)(n,r)/t:32;E.Mat4.targetTo(Tt,e.arcCenter,n<0?e.arcPointD:e.arcPointA,e.arcNormal),E.Mat4.setTranslation(Tt,e.arcCenter),E.Mat4.mul(Tt,Tt,E.Mat4.rotY180);var a=rt({radius:r,thetaLength:Math.abs(n),segments:i});return Object(nt.c)(a,Tt)}var kt={sphereA:Object(I.g)(),sphereB:Object(I.g)(),sphereC:Object(I.g)(),sphereD:Object(I.g)(),dirBA:Object(E.Vec3)(),dirCD:Object(E.Vec3)(),projA:Object(E.Vec3)(),projD:Object(E.Vec3)(),arcPointA:Object(E.Vec3)(),arcPointD:Object(E.Vec3)(),arcDirA:Object(E.Vec3)(),arcDirD:Object(E.Vec3)(),arcCenter:Object(E.Vec3)(),arcNormal:Object(E.Vec3)(),radius:0,angle:0};function Bt(e){return 1===e.quads.length?"Dihedral 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o=Mt(kt,t.dashLength),s=o.indices,u=o.vertices,c=0,l=s.length;c<l;c+=3)if(c%2!=1){var d=3*s[c],f=3*s[c+1],p=u[d],m=u[d+1],h=u[d+2],g=u[f],v=u[f+1],b=u[f+2];n.add(p,m,h,g,v,b,i)}}return n.getLines()}(t,r,n&&n.geometry),a=Bt(t);return m.a.create(a,t,i,(function(){return r.color}),(function(){return r.linesSize}),(function(){return""}))}function Ut(e,t,r,n){var i=function(e,t,r){for(var n=q.a.createState(128,64,r),i=0,a=e.quads.length;i<a;++i){It(e.quads[i],kt,t.arcScale);var o=Mt(kt);n.currentGroup=i,q.a.addPrimitive(n,E.Mat4.id,o),q.a.addPrimitiveFlipped(n,E.Mat4.id,o)}return q.a.getMesh(n)}(t,r,n&&n.geometry),a=Bt(t);return m.a.create(a,t,i,(function(){return r.color}),(function(){return 1}),(function(e){return Object(se.dihedralLabel)(t.quads[e])}))}function zt(e,t,r,n){var i=function(e,t,r){for(var n=oe.a.create(t,128,64,r),i=0,a=e.quads.length;i<a;++i){It(e.quads[i],kt,t.arcScale),E.Vec3.add(Dt,kt.arcDirA,kt.arcDirD),E.Vec3.setMagnitude(Dt,Dt,kt.radius),E.Vec3.add(Dt,kt.arcCenter,Dt);var o=Object(et.f)(kt.angle).toFixed(2);"-0.00"===o&&(o="0.00");var s=t.customText||o+"°",u=Math.max(2,kt.sphereA.radius,kt.sphereB.radius,kt.sphereC.radius,kt.sphereD.radius)/2;n.add(s,Dt[0],Dt[1],Dt[2],.1,u,i)}return n.getText()}(t,r,n&&n.geometry),a=Bt(t);return m.a.create(a,t,i,(function(){return r.textColor}),(function(){return r.textSize}),(function(e){return Object(se.dihedralLabel)(t.quads[e])}))}var Ht,Gt,qt=r(95),Wt=r(85),Xt=r(291),Yt=l.b.BuiltIn({name:"structure-representation-3d",display:"3D Representation",from:l.a.Molecule.Structure,to:l.a.Molecule.Structure.Representation3D,params:function(e,t){var r=t.representation.structure,n=r.registry,a=r.themes,o=n.get(n.default.name);if(!e){var s={help:function(e){var 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i=r.data.source.data,a=t.representation.structure.registry.get(n.type.name);a.ensureCustomProperties&&a.ensureCustomProperties.detach(i),u.a.releaseDependencies(t.representation.structure.themes,{structure:i},n)}},interpolate:function(e,t,r){if("uniform"!==e.colorTheme.name||"uniform"!==t.colorTheme.name)return r<=.5?e:t;var n=e.colorTheme.params.value,i=t.colorTheme.params.value,a=N.Color.interpolate(n,i,r);return{type:r<=.5?e.type:t.type,colorTheme:{name:"uniform",params:{value:a}},sizeTheme:r<=.5?e.sizeTheme:t.sizeTheme}}}),Qt=l.b.BuiltIn({name:"unwind-structure-assembly-representation-3d",display:"Unwind Assembly 3D Representation",from:l.a.Molecule.Structure.Representation3D,to:l.a.Molecule.Structure.Representation3DState,params:{t:c.ParamDefinition.Numeric(0,{min:0,max:1,step:.01})}})({canAutoUpdate:function(){return!0},apply:function(e){var t=e.a,r=e.params,n=t.data.source.data,i=new T(n);return k(n,i,r.t),new 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Object(n.__extends)(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.events.canvas3d.settingsUpdated,(function(){return e.forceUpdate()})),this.subscribe(this.plugin.layout.events.updated,(function(){return e.forceUpdate()})),this.subscribe(this.plugin.behaviors.interaction.selectionMode,(function(){return e.forceUpdate()}))},t.prototype.render=function(){var e=this.props.inline?{background:"transparent",width:"auto",height:"auto",lineHeight:"unset"}:{background:"transparent"};return i.createElement(p.IconButton,{svg:h.SelectionModeSvg,onClick:this._toggleSelMode,title:"Toggle Selection Mode",style:e,toggleState:this.plugin.selectionMode})},t}(d.PurePluginUIComponent),y={granularity:o.a.Params.granularity},_=new Map([["add","Add/Union Selection"],["remove","Remove/Subtract Selection"],["intersect","Intersect Selection"],["set","Set Selection"]]),S=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={action:void 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s=t.atomicHierarchy.index.findAtomOnResidue(a,o,r.label_alt_id.value(e));if(!(s<0))return{residueIndex:a,atomIndex:s,symmetry:r.symmetry.value(e)}}}}}},c=[],l=0;l<e._rowCount;l++){var d=u(l,a),f=u(l,s);if(void 0!==d&&void 0!==f){var p=r.value(l),m=0,h=1;switch((i.value(l)||"").toLowerCase()){case"sing":h=1;break;case"doub":h=2;break;case"trip":h=3;break;case"quad":h=4;break;default:h=Object(o.a)(e.ptnr1_label_comp_id.value(l),e.ptnr1_label_atom_id.value(l),e.ptnr2_label_comp_id.value(l),e.ptnr2_label_atom_id.value(l))}switch(p){case"covale":m=1;break;case"disulf":m=9;break;case"hydrog":m=4;break;case"metalc":m=2}c.push({rowIndex:l,flags:m,order:h,distance:n.value(l),partnerA:d,partnerB:f})}}return c}}(n||(n={}))},function(e,t,r){"use strict";r.d(t,"b",(function(){return g})),r.d(t,"a",(function(){return A}));var n=r(0),i=r(2),a=r(30),o=r(4),s=r(13),u=r(89),c=r(78),l=r(327),d=r(167),f=r(241),p=r(257),m=r(133),h=r(219);function g(e){return 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n,i,a,o,s,u,c=e.state.data.build(),l=e.builders.structure.representation,d={quality:e.managers.structure.component.state.options.visualQuality,ignoreHydrogens:!e.managers.structure.component.state.options.showHydrogens};t.quality&&"auto"!==t.quality&&(d.quality=t.quality),void 0!==t.ignoreHydrogens&&(d.ignoreHydrogens=!!t.ignoreHydrogens);var m,h=(null===(n=t.theme)||void 0===n?void 0:n.globalName)?null===(i=t.theme)||void 0===i?void 0:i.globalName:void 0,g=void 0!==(null===(a=t.theme)||void 0===a?void 0:a.carbonColor)?{carbonColor:(m=null===(o=t.theme)||void 0===o?void 0:o.carbonColor,"chain-id"===m?{name:m,params:f.c.defaultValues}:"operator-name"===m?{name:m,params:p.c.defaultValues}:{name:m,params:{}})}:{};return{update:c,builder:l,color:h,symmetryColor:r&&(null===(s=t.theme)||void 0===s?void 0:s.symmetryColor)&&function(e){return e.units.some((function(e){return!e.conformation.operator.assembly&&e.conformation.operator.spgrOp>=0}))}(r)?null===(u=t.theme)||void 0===u?void 0:u.symmetryColor:h,typeParams:d,ballAndStickColor:g}},e.updateFocusRepr=function(e,t,r,n){return e.state.updateBehavior(l.StructureFocusRepresentation,(function(i){var a=Object(d.createStructureColorThemeParams)(e,t,"ball-and-stick",r||"element-symbol",n);i.surroundingsParams.colorTheme=a,i.targetParams.colorTheme=a}))}}(g||(g={}));var v=g.CommonParams,b=g.reprBuilder,y=g.updateFocusRepr,_=g({id:"preset-structure-representation-auto",display:{name:"Automatic",description:"Show representations based on the size of the structure. 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I.lipid=M.sent(),[4,P(r,h,"coarse")];case 8:return I.coarse=M.sent(),g=I,v=h.obj.data,_={sizeFactor:v.isCoarseGrained?.8:.2},S=((null===(o=null===(a=null===(i=g.water)||void 0===i?void 0:i.obj)||void 0===a?void 0:a.data)||void 0===o?void 0:o.elementCount)||0)>5e4?"line":"ball-and-stick",x=((null===(l=null===(c=null===(u=g.lipid)||void 0===u?void 0:u.obj)||void 0===c?void 0:c.data)||void 0===l?void 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n,i=r(16),a=r(210),o=r(19),s=r(43);!function(e){e.ElementSymbol=i.a.Value("Structure","ElementSymbol"),e.AtomName=i.a.Value("Structure","AtomName"),e.BondFlag=i.a.OneOf("Structure","BondFlag",i.a.Str,["covalent","metallic","ion","hydrogen","sulfide","computed","aromatic"]),e.BondFlags=a.a.Flags(e.BondFlag,"BondFlags"),e.SecondaryStructureFlag=i.a.OneOf("Structure","SecondaryStructureFlag",i.a.Str,["alpha","beta","3-10","pi","sheet","strand","helix","turn","none"]),e.SecondaryStructureFlags=a.a.Flags(e.SecondaryStructureFlag,"SecondaryStructureFlag"),e.RingFingerprint=i.a.Value("Structure","RingFingerprint"),e.EntityType=i.a.OneOf("Structure","EntityType",i.a.Str,["polymer","non-polymer","water","branched"]),e.EntitySubtype=i.a.OneOf("Structure","EntitySubtype",i.a.Str,["other","polypeptide(D)","polypeptide(L)","polydeoxyribonucleotide","polyribonucleotide","polydeoxyribonucleotide/polyribonucleotide hybrid","cyclic-pseudo-peptide","peptide nucleic acid","oligosaccharide"]),e.ObjectPrimitive=i.a.OneOf("Structure","ObjectPrimitive",i.a.Str,["atomistic","sphere","gaussian","other"]),e.ResidueId=i.a.Value("Structure","ResidueId"),e.ElementSet=i.a.Value("Structure","ElementSet"),e.ElementSelection=i.a.Value("Structure","ElementSelection"),e.ElementReference=i.a.Value("Structure","ElementReference"),e.ElementSelectionQuery=a.a.Fn(e.ElementSelection,"ElementSelectionQuery")}(n||(n={}));var u={"@header":"Types",elementSymbol:Object(s.b)(o.b.Dictionary({0:Object(o.a)(i.a.Str)}),n.ElementSymbol,"Create element symbol representation from a string value."),atomName:Object(s.b)(o.b.Dictionary({0:Object(o.a)(i.a.AnyValue)}),n.AtomName,"Convert a value to an atom name."),entityType:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.EntityType)}),n.EntityType,"Create normalized representation of entity type: "+i.a.oneOfValues(n.EntityType).join(", ")+"."),bondFlags:Object(s.b)(o.b.List(n.BondFlag),n.BondFlags,"Create bond flags representation from a list of strings. Allowed flags: "+i.a.oneOfValues(n.BondFlag).join(", ")+"."),ringFingerprint:Object(s.b)(o.b.List(n.ElementSymbol,{nonEmpty:!0}),n.RingFingerprint,"Create ring fingerprint from the supplied atom element list."),secondaryStructureFlags:Object(s.b)(o.b.List(n.SecondaryStructureFlag),n.SecondaryStructureFlags,"Create secondary structure flags representation from a list of strings. Allowed flags: "+i.a.oneOfValues(n.SecondaryStructureFlag).join(", ")+"."),authResidueId:Object(s.b)(o.b.Dictionary({0:Object(o.a)(i.a.Str,{description:"auth_asym_id"}),1:Object(o.a)(i.a.Num,{description:"auth_seq_id"}),2:Object(o.a)(i.a.Str,{description:"pdbx_PDB_ins_code",isOptional:!0})}),n.ResidueId,'Residue identifier based on "auth_" annotation.'),labelResidueId:Object(s.b)(o.b.Dictionary({0:Object(o.a)(i.a.Str,{description:"label_entity_id"}),1:Object(o.a)(i.a.Str,{description:"label_asym_id"}),2:Object(o.a)(i.a.Num,{description:"label_seq_id"}),3:Object(o.a)(i.a.Str,{description:"pdbx_PDB_ins_code",isOptional:!0})}),n.ResidueId,'Residue identifier based on mmCIF\'s "label_" annotation.')},c={"@header":"Iteration Slots",element:Object(s.b)(o.b.None,n.ElementReference,"A reference to the current element."),elementSetReduce:Object(s.b)(o.b.None,i.a.Variable("a",i.a.AnyValue,!0),"Current value of the element set reducer.")},l={"@header":"Generators",all:Object(s.b)(o.b.None,n.ElementSelectionQuery,"The entire structure."),atomGroups:Object(s.b)(o.b.Dictionary({"entity-test":Object(o.a)(i.a.Bool,{isOptional:!0,defaultValue:!0,description:"Test for the 1st atom of every entity"}),"chain-test":Object(o.a)(i.a.Bool,{isOptional:!0,defaultValue:!0,description:"Test for the 1st atom of every chain"}),"residue-test":Object(o.a)(i.a.Bool,{isOptional:!0,defaultValue:!0,description:"Test for the 1st atom every residue"}),"atom-test":Object(o.a)(i.a.Bool,{isOptional:!0,defaultValue:!0}),"group-by":Object(o.a)(i.a.Any,{isOptional:!0,defaultValue:"atom-key",description:"Group atoms to sets based on this property. Default: each atom has its own set"})}),n.ElementSelectionQuery,"Return all atoms for which the tests are satisfied, grouped into sets."),bondedAtomicPairs:Object(s.b)(o.b.Dictionary({0:Object(o.a)(i.a.Bool,{isOptional:!0,defaultValue:"true for covalent bonds",description:"Test each bond with this predicate. Each bond is visited twice with swapped atom order."})}),n.ElementSelectionQuery,"Return all pairs of atoms for which the test is satisfied."),rings:Object(s.b)(o.b.Dictionary({fingerprint:Object(o.a)(n.RingFingerprint,{isOptional:!0}),"only-aromatic":Object(o.a)(i.a.Bool,{isOptional:!0,defaultValue:!1})}),n.ElementSelectionQuery,"Return all rings or those with the specified fingerprint and/or only aromatic rings."),queryInSelection:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.ElementSelectionQuery),query:Object(o.a)(n.ElementSelectionQuery),"in-complement":Object(o.a)(i.a.Bool,{isOptional:!0,defaultValue:!1})}),n.ElementSelectionQuery,"Executes query only on atoms that are in the source selection."),empty:Object(s.b)(o.b.None,n.ElementSelectionQuery,"Nada.")},d={"@header":"Selection Modifications",queryEach:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.ElementSelectionQuery),query:Object(o.a)(n.ElementSelectionQuery)}),n.ElementSelectionQuery,"Query every atom set in the input selection separately."),intersectBy:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.ElementSelectionQuery),by:Object(o.a)(n.ElementSelectionQuery)}),n.ElementSelectionQuery,"Intersect each atom set from the first sequence from atoms in the second one."),exceptBy:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.ElementSelectionQuery),by:Object(o.a)(n.ElementSelectionQuery)}),n.ElementSelectionQuery,"Remove all atoms from 'selection' that occur in 'by'."),unionBy:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.ElementSelectionQuery),by:Object(o.a)(n.ElementSelectionQuery)}),n.ElementSelectionQuery,"For each atom set A in the orginal sequence, combine all atoms sets in the target selection that intersect with A."),union:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.ElementSelectionQuery)}),n.ElementSelectionQuery,"Collects all atom sets in the sequence into a single atom set."),cluster:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.ElementSelectionQuery),"min-distance":Object(o.a)(i.a.Num,{isOptional:!0,defaultValue:0}),"max-distance":Object(o.a)(i.a.Num),"min-size":Object(o.a)(i.a.Num,{description:"Minimal number of sets to merge, must be at least 2",isOptional:!0,defaultValue:2}),"max-size":Object(o.a)(i.a.Num,{description:"Maximal number of sets to merge, if not set, no limit",isOptional:!0})}),n.ElementSelectionQuery,"Combines atom sets that have mutual distance in the interval [min-radius, max-radius]. Minimum/maximum size determines how many atom sets can be combined."),includeSurroundings:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.ElementSelectionQuery),radius:Object(o.a)(i.a.Num),"atom-radius":Object(o.a)(i.a.Num,{isOptional:!0,defaultValue:0,description:"Value added to each atom before the distance check, for example VDW radius. Using this argument is computationally demanding."}),"as-whole-residues":Object(o.a)(i.a.Bool,{isOptional:!0})}),n.ElementSelectionQuery,"For each atom set in the selection, include all surrouding atoms/residues that are within the specified radius."),includeConnected:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.ElementSelectionQuery),"bond-test":Object(o.a)(i.a.Bool,{isOptional:!0,defaultValue:"true for covalent bonds"}),"layer-count":Object(o.a)(i.a.Num,{isOptional:!0,defaultValue:1,description:"Number of bonded layers to include."}),"as-whole-residues":Object(o.a)(i.a.Bool,{isOptional:!0})}),n.ElementSelectionQuery,"Pick all atom sets that are connected to the target."),wholeResidues:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.ElementSelectionQuery)}),n.ElementSelectionQuery,"Expand the selection to whole residues."),expandProperty:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.ElementSelectionQuery),property:Object(o.a)(i.a.AnyValue)}),n.ElementSelectionQuery,"To each atom set in the selection, add all atoms that have the same property value that was already present in the set.")},f={"@header":"Selection Filters",pick:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.ElementSelectionQuery),test:Object(o.a)(i.a.Bool)}),n.ElementSelectionQuery,"Pick all atom sets that satisfy the test."),first:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.ElementSelectionQuery)}),n.ElementSelectionQuery,"Take the 1st atom set in the sequence."),withSameAtomProperties:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.ElementSelectionQuery),source:Object(o.a)(n.ElementSelectionQuery),property:Object(o.a)(i.a.Any)}),n.ElementSelectionQuery,"Pick all atom sets for which the set of given atom properties is a subset of the source properties."),intersectedBy:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.ElementSelectionQuery),by:Object(o.a)(n.ElementSelectionQuery)}),n.ElementSelectionQuery,"Pick all atom sets that have non-zero intersection with the target."),within:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.ElementSelectionQuery),target:Object(o.a)(n.ElementSelectionQuery),"min-radius":Object(o.a)(i.a.Num,{isOptional:!0,defaultValue:0}),"max-radius":Object(o.a)(i.a.Num),"atom-radius":Object(o.a)(i.a.Num,{isOptional:!0,defaultValue:0,description:"Value added to each atom before the distance check, for example VDW radius. Using this argument is computationally demanding."}),invert:Object(o.a)(i.a.Bool,{isOptional:!0,defaultValue:!1,description:"If true, pick only atom sets that are further than the specified radius."})}),n.ElementSelectionQuery,"Pick all atom sets from selection that have any atom within the radius of any atom from target."),isConnectedTo:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.ElementSelectionQuery),target:Object(o.a)(n.ElementSelectionQuery),"bond-test":Object(o.a)(i.a.Bool,{isOptional:!0,defaultValue:"true for covalent bonds"}),disjunct:Object(o.a)(i.a.Bool,{isOptional:!0,defaultValue:!0,description:"If true, there must exist a bond to an atom that lies outside the given atom set to pass test."}),invert:Object(o.a)(i.a.Bool,{isOptional:!0,defaultValue:!1,description:"If true, return atom sets that are not connected."})}),n.ElementSelectionQuery,"Pick all atom sets that are connected to the target.")},p={"@header":"Selection Combinators",intersect:Object(s.b)(o.b.List(n.ElementSelectionQuery),n.ElementSelectionQuery,"Return all unique atom sets that appear in all of the source selections."),merge:Object(s.b)(o.b.List(n.ElementSelectionQuery),n.ElementSelectionQuery,"Merges multiple selections into a single one. Only unique atom sets are kept."),distanceCluster:Object(s.b)(o.b.Dictionary({matrix:Object(o.a)(a.a.List(a.a.List(i.a.Num)),{description:"Distance matrix, represented as list of rows (num[][])). Lower triangle is min distance, upper triangle is max distance."}),selections:Object(o.a)(a.a.List(n.ElementSelectionQuery),{description:"A list of held selections."})}),n.ElementSelectionQuery,"Pick combinations of atom sets from the source sequences that are mutually within distances specified by a matrix.")},m={"@header":"Atom Sets",atomCount:Object(s.b)(o.b.None,i.a.Num),countQuery:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.ElementSelectionQuery)}),i.a.Num,"Counts the number of occurences of a specific query inside the current atom set."),reduce:Object(s.b)(o.b.Dictionary({initial:Object(o.a)(i.a.Variable("a",i.a.AnyValue,!0),{description:"Initial value assigned to slot.atom-set-reduce. Current atom is set to the 1st atom of the current set for this."}),value:Object(o.a)(i.a.Variable("a",i.a.AnyValue,!0),{description:"Expression executed for each atom in the set"})}),i.a.Variable("a",i.a.AnyValue,!0),"Execute the value expression for each atom in the current atom set and return the result. Works the same way as Array.reduce in JavaScript (``result = value(value(...value(initial)))``)"),propertySet:Object(s.b)(o.b.Dictionary({0:Object(o.a)(a.a.ConstrainedVar)}),a.a.Set(a.a.ConstrainedVar),"Returns a set with all values of the given property in the current atom set.")},h={"@header":"Atom Properties",core:{"@header":"Core Properties",elementSymbol:v(n.ElementSymbol),vdw:v(i.a.Num,"Van der Waals radius"),mass:v(i.a.Num,"Atomic weight"),atomicNumber:v(i.a.Num,"Atomic number"),x:v(i.a.Num,"Cartesian X coordinate"),y:v(i.a.Num,"Cartesian Y coordinate"),z:v(i.a.Num,"Cartesian Z coordinate"),atomKey:v(i.a.AnyValue,"Unique value for each atom. Main use case is grouping of atoms."),bondCount:Object(s.b)(o.b.Dictionary({0:Object(o.a)(n.ElementReference,{isOptional:!0,defaultValue:"slot.current-atom"}),flags:Object(o.a)(n.BondFlags,{isOptional:!0,defaultValue:"covalent"})}),i.a.Num,"Number of bonds (by default only covalent bonds are counted)."),sourceIndex:v(i.a.Num,"Index of the atom/element in the input file."),operatorName:v(i.a.Str,"Name of the symmetry operator applied to this element."),modelIndex:v(i.a.Num,"Index of the model in the input file."),modelLabel:v(i.a.Str,"Label/header of the model in the input file.")},topology:{connectedComponentKey:v(i.a.AnyValue,"Unique value for each connected component.")},macromolecular:{"@header":"Macromolecular Properties (derived from the mmCIF format)",authResidueId:v(n.ResidueId,"type.auth-residue-id symbol executed on current atom's residue"),labelResidueId:v(n.ResidueId,"type.label-residue-id symbol executed on current atom's residue"),residueKey:v(i.a.AnyValue,"Unique value for each tuple ``(label_entity_id,auth_asym_id, auth_seq_id, pdbx_PDB_ins_code)``, main use case is grouping of atoms"),chainKey:v(i.a.AnyValue,"Unique value for each tuple ``(label_entity_id, auth_asym_id)``, main use case is grouping of atoms"),entityKey:v(i.a.AnyValue,"Unique value for each tuple ``label_entity_id``, main use case is grouping of atoms"),isHet:v(i.a.Bool,"Equivalent to atom_site.group_PDB !== ATOM"),id:v(i.a.Num,"_atom_site.id"),label_atom_id:v(n.AtomName),label_alt_id:v(i.a.Str),label_comp_id:v(i.a.Str),label_asym_id:v(i.a.Str),label_entity_id:v(i.a.Str),label_seq_id:v(i.a.Num),auth_atom_id:v(n.AtomName),auth_comp_id:v(i.a.Str),auth_asym_id:v(i.a.Str),auth_seq_id:v(i.a.Num),pdbx_PDB_ins_code:v(i.a.Str),pdbx_formal_charge:v(i.a.Num),occupancy:v(i.a.Num),B_iso_or_equiv:v(i.a.Num),entityType:v(n.EntityType,"Type of the entity as defined in mmCIF (polymer, non-polymer, branched, water)"),entitySubtype:v(n.EntitySubtype,"Subtype of the entity as defined in mmCIF _entity_poly.type and _pdbx_entity_branch.type (other, polypeptide(D), polypeptide(L), polydeoxyribonucleotide, polyribonucleotide, polydeoxyribonucleotide/polyribonucleotide hybrid, cyclic-pseudo-peptide, peptide nucleic acid, oligosaccharide)"),entityPrdId:v(i.a.Str,"The PRD ID of the entity."),entityDescription:v(a.a.List(i.a.Str)),objectPrimitive:v(n.ObjectPrimitive,"Type of the primitive object used to model this segment as defined in mmCIF/IHM (atomistic, sphere, gaussian, other)"),secondaryStructureKey:v(i.a.AnyValue,"Unique value for each secondary structure element."),secondaryStructureFlags:v(n.SecondaryStructureFlags),isModified:v(i.a.Bool,"True if the atom belongs to modification of a standard residue."),modifiedParentName:v(i.a.Str,"'3-letter' code of the modifed parent residue."),isNonStandard:v(i.a.Bool,"True if this is a non-standard residue."),chemCompType:v(i.a.Str,"Type of the chemical component as defined in mmCIF.")}},g={"@header":"Bond 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d=n.instanceCount,y=n.groupCount,O=e.Utils.createPositionIterator(t,r),w=Object(p.a)(n,O,a.color),C=Object(m.a)(d*y),j=Object(h.c)(),P=Object(g.c)(),E=Object(b.d)(),A={drawCount:S.length,vertexCount:_.a.length/3,groupCount:y,instanceCount:d},D=u.g.clone(t.boundingSphere),T=Object(s.b)(D,r.aTransform.ref.value,d);return Object(i.__assign)(Object(i.__assign)(Object(i.__assign)(Object(i.__assign)(Object(i.__assign)(Object(i.__assign)(Object(i.__assign)(Object(i.__assign)({},w),C),j),P),E),r),f.a.createValues(o,A)),{aPosition:t.cornerBuffer,aUv:l.e.create(x),elements:l.e.create(S),aGroup:l.e.create(Object(v.fillSerial)(new Float32Array(4))),boundingSphere:l.e.create(T),invariantBoundingSphere:l.e.create(D),uInvariantBoundingSphere:l.e.create(c.Vec4.ofSphere(D)),dInterpolation:l.e.create(o.interpolation),uImageTexDim:t.imageTextureDim,tImageTex:t.imageTexture,tGroupTex:t.groupTexture})}e.create=function(e,t,r,n){return n?function(e,t,r,n){var i=e.width,a=e.height;return 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e,t,r,n,i,a=this.makeScoreFn(),o=this,s=o.V,u=o.H,c=o.S,l=o.n,d=o.m,f=o.gapExtensionPenalty,p=o.gapPenalty,m=1;m<=l;++m){t=c[m-1],e=s[m-1],r=s[m],n=u[m],i=c[m];for(var h=1;h<=d;++h)r[h]=Math.max(t[h]+p,e[h]+f),n[h]=Math.max(i[h-1]+p,n[h-1]+f),i[h]=Math.max(t[h-1]+a(m-1,h-1),r[h],n[h])}},e.prototype.trace=function(){var e,t,r=this.makeScoreFn(),n=this,i=n.V,a=n.H,o=n.S,s=n.seqA,u=n.seqB,c=n.gapExtensionPenalty,l=n.gapPenalty,d=this.n,f=this.m,p="",m="";for(o[d][f]>=i[d][f]?(e="S",t=o[d][f]):i[d][f]>=a[d][f]?(e="V",t=i[d][f]):(e="H",t=a[d][f]);d>0&&f>0;)"S"===e?o[d][f]===o[d-1][f-1]+r(d-1,f-1)?(p=s[d-1]+p,m=u[f-1]+m,--d,--f,e="S"):o[d][f]===i[d][f]?e="V":o[d][f]===a[d][f]?e="H":(--d,--f):"V"===e?i[d][f]===i[d-1][f]+c?(p=s[d-1]+p,m="-"+m,--d,e="V"):i[d][f]===o[d-1][f]+l?(p=s[d-1]+p,m="-"+m,--d,e="S"):--d:"H"===e&&(a[d][f]===a[d][f-1]+c?(p="-"+p,m=u[f-1]+m,--f,e="H"):a[d][f]===o[d][f-1]+l?(p="-"+p,m=u[f-1]+m,--f,e="S"):--f);for(;d>0;)p=s[d-1]+p,m="-"+m,--d;for(;f>0;)p="-"+p,m=u[f-1]+m,--f;return{aliA:p,aliB:m,score:t}},e}();function K(e){return e.model.sequence.byEntityKey[function(e){switch(e.kind){case 0:return e.model.atomicHierarchy.index.getEntityFromChain(e.chainIndex[e.elements[0]]);case 1:return e.model.coarseHierarchy.spheres.entityKey[e.elements[0]];case 2:return 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Object(n.__extends)(t,e),t.prototype.defaultState=function(){return{isCollapsed:!1,header:"Superposition",brand:{accent:"gray",svg:w.SuperpositionSvg},isHidden:!0}},t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.managers.structure.hierarchy.behaviors.selection,(function(t){e.setState({isHidden:t.structures.length<2})}))},t.prototype.renderControls=function(){return i.createElement(i.Fragment,null,i.createElement(ue,null))},t}(x.CollapsableControls),oe={alignSequences:s.ParamDefinition.Boolean(!0,{isEssential:!0,description:"Perform a sequence alignment and use the aligned residue pairs to guide the 3D superposition."})},se=s.ParamDefinition.getDefaultValues(oe),ue=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={isBusy:!1,action:void 0,options:se},t.superposeChains=function(){return Object(n.__awaiter)(t,void 0,void 0,(function(){var e,t,r,i,a,o,s,u,c,l,d,f,p,m=this;return 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Object(n.__extends)(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.selection.events.changed,(function(){e.forceUpdate()})),this.subscribe(this.selection.events.additionsHistoryUpdated,(function(){e.forceUpdate()})),this.subscribe(this.plugin.behaviors.state.isBusy,(function(t){e.setState({isBusy:t})}))},Object.defineProperty(t.prototype,"selection",{get:function(){return this.plugin.managers.structure.selection},enumerable:!1,configurable:!0}),t.prototype.transform=function(e,t){return Object(n.__awaiter)(this,void 0,void 0,(function(){var r,i,o,s;return Object(n.__generator)(this,(function(n){switch(n.label){case 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t=this.destination;this.acc=e,this.hasValue=!0,t.next(e)},t.prototype.notifyComplete=function(){var e=this.buffer;this.active--,e.length>0?this._next(e.shift()):0===this.active&&this.hasCompleted&&(!1===this.hasValue&&this.destination.next(this.acc),this.destination.complete())},t}(i.b);function Lt(e){return At("function"==typeof e?function(t,r){return e(t,r)<0?t:r}:function(e,t){return e<t?e:t})}var Nt=r(356);function Ft(e,t){return function(r){var n;if(n="function"==typeof e?e:function(){return e},"function"==typeof t)return r.lift(new Ut(n,t));var i=Object.create(r,Nt.b);return i.source=r,i.subjectFactory=n,i}}var Ut=function(){function e(e,t){this.subjectFactory=e,this.selector=t}return e.prototype.call=function(e,t){var r=this.selector,n=this.subjectFactory(),i=r(n).subscribe(e);return i.add(t.subscribe(n)),i},e}(),zt=r(357);function Ht(){for(var e=[],t=0;t<arguments.length;t++)e[t]=arguments[t];return 1===e.length&&Object(U.a)(e[0])&&(e=e[0]),function(t){return t.lift(new Gt(e))}}var Gt=function(){function e(e){this.nextSources=e}return e.prototype.call=function(e,t){return t.subscribe(new qt(e,this.nextSources))},e}(),qt=function(e){function t(t,r){var n=e.call(this,t)||this;return n.destination=t,n.nextSources=r,n}return n.a(t,e),t.prototype.notifyError=function(){this.subscribeToNextSource()},t.prototype.notifyComplete=function(){this.subscribeToNextSource()},t.prototype._error=function(e){this.subscribeToNextSource(),this.unsubscribe()},t.prototype._complete=function(){this.subscribeToNextSource(),this.unsubscribe()},t.prototype.subscribeToNextSource=function(){var e=this.nextSources.shift();if(e){var t=new i.a(this),r=this.destination;r.add(t);var n=Object(i.c)(e,t);n!==t&&r.add(n)}else this.destination.complete()},t}(i.b);function Wt(){return function(e){return e.lift(new Xt)}}var Xt=function(){function e(){}return e.prototype.call=function(e,t){return t.subscribe(new Yt(e))},e}(),Yt=function(e){function t(t){var r=e.call(this,t)||this;return r.hasPrev=!1,r}return n.a(t,e),t.prototype._next=function(e){var t;this.hasPrev?t=[this.prev,e]:this.hasPrev=!0,this.prev=e,t&&this.destination.next(t)},t}(m.a),Qt=r(389);function Kt(e,t){return function(r){return[Object(Ae.a)(e,t)(r),Object(Ae.a)(Object(Qt.a)(e,t))(r)]}}function Zt(){for(var e=[],t=0;t<arguments.length;t++)e[t]=arguments[t];var r=e.length;if(0===r)throw new Error("list of properties cannot be empty.");return function(t){return Object(qe.a)(Jt(e,r))(t)}}function Jt(e,t){return function(r){for(var n=r,i=0;i<t;i++){var a=null!=n?n[e[i]]:void 0;if(void 0===a)return;n=a}return n}}var $t=r(62);function er(e){return e?Ft((function(){return new $t.a}),e):Ft(new $t.a)}var tr=r(245);function rr(e){return function(t){return Ft(new tr.a(e))(t)}}var nr=r(237);function ir(){return function(e){return Ft(new nr.a)(e)}}var ar=r(305);function or(e,t,r,n){r&&"function"!=typeof r&&(n=r);var i="function"==typeof r?r:void 0,a=new ar.a(e,t,n);return function(e){return Ft((function(){return a}),i)(e)}}var sr=r(358);function ur(){for(var e=[],t=0;t<arguments.length;t++)e[t]=arguments[t];return function(t){return 1===e.length&&Object(U.a)(e[0])&&(e=e[0]),t.lift.call(sr.a.apply(void 0,[t].concat(e)))}}function cr(e){return void 0===e&&(e=-1),function(t){return 0===e?Object(mt.b)():e<0?t.lift(new lr(-1,t)):t.lift(new lr(e-1,t))}}var lr=function(){function e(e,t){this.count=e,this.source=t}return e.prototype.call=function(e,t){return t.subscribe(new dr(e,this.count,this.source))},e}(),dr=function(e){function t(t,r,n){var i=e.call(this,t)||this;return i.count=r,i.source=n,i}return n.a(t,e),t.prototype.complete=function(){if(!this.isStopped){var t=this.source,r=this.count;if(0===r)return e.prototype.complete.call(this);r>-1&&(this.count=r-1),t.subscribe(this._unsubscribeAndRecycle())}},t}(m.a);function fr(e){return function(t){return t.lift(new pr(e))}}var pr=function(){function e(e){this.notifier=e}return e.prototype.call=function(e,t){return t.subscribe(new mr(e,this.notifier,t))},e}(),mr=function(e){function t(t,r,n){var i=e.call(this,t)||this;return i.notifier=r,i.source=n,i.sourceIsBeingSubscribedTo=!0,i}return n.a(t,e),t.prototype.notifyNext=function(){this.sourceIsBeingSubscribedTo=!0,this.source.subscribe(this)},t.prototype.notifyComplete=function(){if(!1===this.sourceIsBeingSubscribedTo)return e.prototype.complete.call(this)},t.prototype.complete=function(){if(this.sourceIsBeingSubscribedTo=!1,!this.isStopped){if(this.retries||this.subscribeToRetries(),!this.retriesSubscription||this.retriesSubscription.closed)return e.prototype.complete.call(this);this._unsubscribeAndRecycle(),this.notifications.next(void 0)}},t.prototype._unsubscribe=function(){var e=this.notifications,t=this.retriesSubscription;e&&(e.unsubscribe(),this.notifications=void 0),t&&(t.unsubscribe(),this.retriesSubscription=void 0),this.retries=void 0},t.prototype._unsubscribeAndRecycle=function(){var t=this._unsubscribe;return this._unsubscribe=null,e.prototype._unsubscribeAndRecycle.call(this),this._unsubscribe=t,this},t.prototype.subscribeToRetries=function(){var t;this.notifications=new $t.a;try{t=(0,this.notifier)(this.notifications)}catch(t){return e.prototype.complete.call(this)}this.retries=t,this.retriesSubscription=Object(i.c)(t,new i.a(this))},t}(i.b);function hr(e){return void 0===e&&(e=-1),function(t){return t.lift(new gr(e,t))}}var gr=function(){function e(e,t){this.count=e,this.source=t}return e.prototype.call=function(e,t){return t.subscribe(new vr(e,this.count,this.source))},e}(),vr=function(e){function t(t,r,n){var i=e.call(this,t)||this;return i.count=r,i.source=n,i}return n.a(t,e),t.prototype.error=function(t){if(!this.isStopped){var r=this.source,n=this.count;if(0===n)return e.prototype.error.call(this,t);n>-1&&(this.count=n-1),r.subscribe(this._unsubscribeAndRecycle())}},t}(m.a);function br(e){return function(t){return t.lift(new yr(e,t))}}var yr=function(){function e(e,t){this.notifier=e,this.source=t}return e.prototype.call=function(e,t){return t.subscribe(new _r(e,this.notifier,this.source))},e}(),_r=function(e){function t(t,r,n){var i=e.call(this,t)||this;return i.notifier=r,i.source=n,i}return n.a(t,e),t.prototype.error=function(t){if(!this.isStopped){var r=this.errors,n=this.retries,a=this.retriesSubscription;if(n)this.errors=void 0,this.retriesSubscription=void 0;else{r=new $t.a;try{n=(0,this.notifier)(r)}catch(t){return e.prototype.error.call(this,t)}a=Object(i.c)(n,new i.a(this))}this._unsubscribeAndRecycle(),this.errors=r,this.retries=n,this.retriesSubscription=a,r.next(t)}},t.prototype._unsubscribe=function(){var e=this.errors,t=this.retriesSubscription;e&&(e.unsubscribe(),this.errors=void 0),t&&(t.unsubscribe(),this.retriesSubscription=void 0),this.retries=void 0},t.prototype.notifyNext=function(){var e=this._unsubscribe;this._unsubscribe=null,this._unsubscribeAndRecycle(),this._unsubscribe=e,this.source.subscribe(this)},t}(i.b),Sr=r(304);function xr(e){return function(t){return t.lift(new Or(e))}}var Or=function(){function e(e){this.notifier=e}return e.prototype.call=function(e,t){var r=new wr(e),n=t.subscribe(r);return n.add(Object(i.c)(this.notifier,new i.a(r))),n},e}(),wr=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.hasValue=!1,t}return n.a(t,e),t.prototype._next=function(e){this.value=e,this.hasValue=!0},t.prototype.notifyNext=function(){this.emitValue()},t.prototype.notifyComplete=function(){this.emitValue()},t.prototype.emitValue=function(){this.hasValue&&(this.hasValue=!1,this.destination.next(this.value))},t}(i.b);function Cr(e,t){return void 0===t&&(t=u.a),function(r){return r.lift(new jr(e,t))}}var jr=function(){function e(e,t){this.period=e,this.scheduler=t}return e.prototype.call=function(e,t){return t.subscribe(new Pr(e,this.period,this.scheduler))},e}(),Pr=function(e){function t(t,r,n){var i=e.call(this,t)||this;return i.period=r,i.scheduler=n,i.hasValue=!1,i.add(n.schedule(Er,r,{subscriber:i,period:r})),i}return n.a(t,e),t.prototype._next=function(e){this.lastValue=e,this.hasValue=!0},t.prototype.notifyNext=function(){this.hasValue&&(this.hasValue=!1,this.destination.next(this.lastValue))},t}(m.a);function Er(e){var t=e.subscriber,r=e.period;t.notifyNext(),this.schedule(e,r)}function Ar(e,t){return function(r){return r.lift(new Dr(e,t))}}var Dr=function(){function e(e,t){this.compareTo=e,this.comparator=t}return e.prototype.call=function(e,t){return t.subscribe(new Tr(e,this.compareTo,this.comparator))},e}(),Tr=function(e){function t(t,r,n){var i=e.call(this,t)||this;return i.compareTo=r,i.comparator=n,i._a=[],i._b=[],i._oneComplete=!1,i.destination.add(r.subscribe(new Ir(t,i))),i}return n.a(t,e),t.prototype._next=function(e){this._oneComplete&&0===this._b.length?this.emit(!1):(this._a.push(e),this.checkValues())},t.prototype._complete=function(){this._oneComplete?this.emit(0===this._a.length&&0===this._b.length):this._oneComplete=!0,this.unsubscribe()},t.prototype.checkValues=function(){for(var e=this._a,t=this._b,r=this.comparator;e.length>0&&t.length>0;){var n=e.shift(),i=t.shift(),a=!1;try{a=r?r(n,i):n===i}catch(e){this.destination.error(e)}a||this.emit(!1)}},t.prototype.emit=function(e){var t=this.destination;t.next(e),t.complete()},t.prototype.nextB=function(e){this._oneComplete&&0===this._a.length?this.emit(!1):(this._b.push(e),this.checkValues())},t.prototype.completeB=function(){this._oneComplete?this.emit(0===this._a.length&&0===this._b.length):this._oneComplete=!0},t}(m.a),Ir=function(e){function t(t,r){var n=e.call(this,t)||this;return n.parent=r,n}return n.a(t,e),t.prototype._next=function(e){this.parent.nextB(e)},t.prototype._error=function(e){this.parent.error(e),this.unsubscribe()},t.prototype._complete=function(){this.parent.completeB(),this.unsubscribe()},t}(m.a);function Mr(){return new $t.a}function kr(){return function(e){return Object(Sr.a)()(Ft(Mr)(e))}}function Br(e,t,r){var n;return n=e&&"object"==typeof e?e:{bufferSize:e,windowTime:t,refCount:!1,scheduler:r},function(e){return e.lift(function(e){var t,r,n=e.bufferSize,i=void 0===n?Number.POSITIVE_INFINITY:n,a=e.windowTime,o=void 0===a?Number.POSITIVE_INFINITY:a,s=e.refCount,u=e.scheduler,c=0,l=!1,d=!1;return function(e){var n;c++,!t||l?(l=!1,t=new ar.a(i,o,u),n=t.subscribe(this),r=e.subscribe({next:function(e){t.next(e)},error:function(e){l=!0,t.error(e)},complete:function(){d=!0,r=void 0,t.complete()}}),d&&(r=void 0)):n=t.subscribe(this),this.add((function(){c--,n.unsubscribe(),n=void 0,r&&!d&&s&&0===c&&(r.unsubscribe(),r=void 0,t=void 0)}))}}(n))}}function Vr(e){return function(t){return t.lift(new Rr(e,t))}}var Rr=function(){function e(e,t){this.predicate=e,this.source=t}return e.prototype.call=function(e,t){return t.subscribe(new Lr(e,this.predicate,this.source))},e}(),Lr=function(e){function t(t,r,n){var i=e.call(this,t)||this;return i.predicate=r,i.source=n,i.seenValue=!1,i.index=0,i}return n.a(t,e),t.prototype.applySingleValue=function(e){this.seenValue?this.destination.error("Sequence contains more than one element"):(this.seenValue=!0,this.singleValue=e)},t.prototype._next=function(e){var t=this.index++;this.predicate?this.tryNext(e,t):this.applySingleValue(e)},t.prototype.tryNext=function(e,t){try{this.predicate(e,t,this.source)&&this.applySingleValue(e)}catch(e){this.destination.error(e)}},t.prototype._complete=function(){var e=this.destination;this.index>0?(e.next(this.seenValue?this.singleValue:void 0),e.complete()):e.error(new De.a)},t}(m.a);function Nr(e){return function(t){return t.lift(new Fr(e))}}var Fr=function(){function e(e){this.total=e}return e.prototype.call=function(e,t){return t.subscribe(new Ur(e,this.total))},e}(),Ur=function(e){function t(t,r){var n=e.call(this,t)||this;return n.total=r,n.count=0,n}return n.a(t,e),t.prototype._next=function(e){++this.count>this.total&&this.destination.next(e)},t}(m.a);function zr(e){return function(t){return t.lift(new Hr(e))}}var Hr=function(){function e(e){if(this._skipCount=e,this._skipCount<0)throw new Ee.a}return e.prototype.call=function(e,t){return 0===this._skipCount?t.subscribe(new m.a(e)):t.subscribe(new Gr(e,this._skipCount))},e}(),Gr=function(e){function t(t,r){var n=e.call(this,t)||this;return n._skipCount=r,n._count=0,n._ring=new Array(r),n}return n.a(t,e),t.prototype._next=function(e){var t=this._skipCount,r=this._count++;if(r<t)this._ring[r]=e;else{var n=r%t,i=this._ring,a=i[n];i[n]=e,this.destination.next(a)}},t}(m.a);function qr(e){return function(t){return t.lift(new Wr(e))}}var Wr=function(){function e(e){this.notifier=e}return e.prototype.call=function(e,t){return t.subscribe(new Xr(e,this.notifier))},e}(),Xr=function(e){function t(t,r){var n=e.call(this,t)||this;n.hasValue=!1;var a=new i.a(n);n.add(a),n.innerSubscription=a;var o=Object(i.c)(r,a);return o!==a&&(n.add(o),n.innerSubscription=o),n}return n.a(t,e),t.prototype._next=function(t){this.hasValue&&e.prototype._next.call(this,t)},t.prototype.notifyNext=function(){this.hasValue=!0,this.innerSubscription&&this.innerSubscription.unsubscribe()},t.prototype.notifyComplete=function(){},t}(i.b);function Yr(e){return function(t){return t.lift(new Qr(e))}}var Qr=function(){function e(e){this.predicate=e}return e.prototype.call=function(e,t){return t.subscribe(new Kr(e,this.predicate))},e}(),Kr=function(e){function t(t,r){var n=e.call(this,t)||this;return n.predicate=r,n.skipping=!0,n.index=0,n}return n.a(t,e),t.prototype._next=function(e){var t=this.destination;this.skipping&&this.tryCallPredicate(e),this.skipping||t.next(e)},t.prototype.tryCallPredicate=function(e){try{var t=this.predicate(e,this.index++);this.skipping=Boolean(t)}catch(e){this.destination.error(e)}},t}(m.a);function Zr(){for(var e=[],t=0;t<arguments.length;t++)e[t]=arguments[t];var r=e[e.length-1];return Object(y.a)(r)?(e.pop(),function(t){return Object(G.a)(e,t,r)}):function(t){return Object(G.a)(e,t)}}var Jr=r(283),$r=r(243),en=function(e){function t(t,r,n){void 0===r&&(r=0),void 0===n&&(n=Jr.a);var i=e.call(this)||this;return i.source=t,i.delayTime=r,i.scheduler=n,(!Object($r.a)(r)||r<0)&&(i.delayTime=0),n&&"function"==typeof n.schedule||(i.scheduler=Jr.a),i}return n.a(t,e),t.create=function(e,r,n){return void 0===r&&(r=0),void 0===n&&(n=Jr.a),new t(e,r,n)},t.dispatch=function(e){var t=e.source,r=e.subscriber;return this.add(t.subscribe(r))},t.prototype._subscribe=function(e){var r=this.delayTime,n=this.source;return this.scheduler.schedule(t.dispatch,r,{source:n,subscriber:e})},t}(fe.a);function tn(e,t){return void 0===t&&(t=0),function(r){return r.lift(new rn(e,t))}}var rn=function(){function e(e,t){this.scheduler=e,this.delay=t}return e.prototype.call=function(e,t){return new en(t,this.delay,this.scheduler).subscribe(e)},e}();function nn(e,t){return"function"==typeof t?function(r){return r.pipe(nn((function(r,n){return Object(z.a)(e(r,n)).pipe(Object(qe.a)((function(e,i){return t(r,e,n,i)})))})))}:function(t){return t.lift(new an(e))}}var an=function(){function e(e){this.project=e}return e.prototype.call=function(e,t){return t.subscribe(new on(e,this.project))},e}(),on=function(e){function t(t,r){var n=e.call(this,t)||this;return n.project=r,n.index=0,n}return n.a(t,e),t.prototype._next=function(e){var t,r=this.index++;try{t=this.project(e,r)}catch(e){return void this.destination.error(e)}this._innerSub(t)},t.prototype._innerSub=function(e){var t=this.innerSubscription;t&&t.unsubscribe();var r=new i.a(this),n=this.destination;n.add(r),this.innerSubscription=Object(i.c)(e,r),this.innerSubscription!==r&&n.add(this.innerSubscription)},t.prototype._complete=function(){var t=this.innerSubscription;t&&!t.closed||e.prototype._complete.call(this),this.unsubscribe()},t.prototype._unsubscribe=function(){this.innerSubscription=void 0},t.prototype.notifyComplete=function(){this.innerSubscription=void 0,this.isStopped&&e.prototype._complete.call(this)},t.prototype.notifyNext=function(e){this.destination.next(e)},t}(i.b);function sn(){return nn(at.a)}function un(e,t){return t?nn((function(){return e}),t):nn((function(){return e}))}function cn(e){return function(t){return t.lift(new ln(e))}}var ln=function(){function e(e){this.notifier=e}return e.prototype.call=function(e,t){var r=new dn(e),n=Object(i.c)(this.notifier,new i.a(r));return n&&!r.seenValue?(r.add(n),t.subscribe(r)):r},e}(),dn=function(e){function t(t){var r=e.call(this,t)||this;return r.seenValue=!1,r}return n.a(t,e),t.prototype.notifyNext=function(){this.seenValue=!0,this.complete()},t.prototype.notifyComplete=function(){},t}(i.b);function fn(e,t){return void 0===t&&(t=!1),function(r){return r.lift(new pn(e,t))}}var pn=function(){function e(e,t){this.predicate=e,this.inclusive=t}return e.prototype.call=function(e,t){return t.subscribe(new mn(e,this.predicate,this.inclusive))},e}(),mn=function(e){function t(t,r,n){var i=e.call(this,t)||this;return i.predicate=r,i.inclusive=n,i.index=0,i}return n.a(t,e),t.prototype._next=function(e){var t,r=this.destination;try{t=this.predicate(e,this.index++)}catch(e){return void r.error(e)}this.nextOrComplete(e,t)},t.prototype.nextOrComplete=function(e,t){var r=this.destination;Boolean(t)?r.next(e):(this.inclusive&&r.next(e),r.complete())},t}(m.a),hn=r(207),gn=r(223);function vn(e,t,r){return function(n){return n.lift(new bn(e,t,r))}}var bn=function(){function e(e,t,r){this.nextOrObserver=e,this.error=t,this.complete=r}return e.prototype.call=function(e,t){return t.subscribe(new yn(e,this.nextOrObserver,this.error,this.complete))},e}(),yn=function(e){function t(t,r,n,i){var a=e.call(this,t)||this;return a._tapNext=hn.a,a._tapError=hn.a,a._tapComplete=hn.a,a._tapError=n||hn.a,a._tapComplete=i||hn.a,Object(gn.a)(r)?(a._context=a,a._tapNext=r):r&&(a._context=r,a._tapNext=r.next||hn.a,a._tapError=r.error||hn.a,a._tapComplete=r.complete||hn.a),a}return n.a(t,e),t.prototype._next=function(e){try{this._tapNext.call(this._context,e)}catch(e){return void this.destination.error(e)}this.destination.next(e)},t.prototype._error=function(e){try{this._tapError.call(this._context,e)}catch(e){return void this.destination.error(e)}this.destination.error(e)},t.prototype._complete=function(){try{this._tapComplete.call(this._context)}catch(e){return void this.destination.error(e)}return this.destination.complete()},t}(m.a),_n={leading:!0,trailing:!1};function Sn(e,t){return void 0===t&&(t=_n),function(r){return r.lift(new xn(e,!!t.leading,!!t.trailing))}}var xn=function(){function e(e,t,r){this.durationSelector=e,this.leading=t,this.trailing=r}return e.prototype.call=function(e,t){return t.subscribe(new On(e,this.durationSelector,this.leading,this.trailing))},e}(),On=function(e){function t(t,r,n,i){var a=e.call(this,t)||this;return a.destination=t,a.durationSelector=r,a._leading=n,a._trailing=i,a._hasValue=!1,a}return n.a(t,e),t.prototype._next=function(e){this._hasValue=!0,this._sendValue=e,this._throttled||(this._leading?this.send():this.throttle(e))},t.prototype.send=function(){var e=this._hasValue,t=this._sendValue;e&&(this.destination.next(t),this.throttle(t)),this._hasValue=!1,this._sendValue=void 0},t.prototype.throttle=function(e){var t=this.tryDurationSelector(e);t&&this.add(this._throttled=Object(i.c)(t,new i.a(this)))},t.prototype.tryDurationSelector=function(e){try{return this.durationSelector(e)}catch(e){return this.destination.error(e),null}},t.prototype.throttlingDone=function(){var e=this._throttled,t=this._trailing;e&&e.unsubscribe(),this._throttled=void 0,t&&this.send()},t.prototype.notifyNext=function(){this.throttlingDone()},t.prototype.notifyComplete=function(){this.throttlingDone()},t}(i.b);function wn(e,t,r){return void 0===t&&(t=u.a),void 0===r&&(r=_n),function(n){return n.lift(new Cn(e,t,r.leading,r.trailing))}}var Cn=function(){function e(e,t,r,n){this.duration=e,this.scheduler=t,this.leading=r,this.trailing=n}return e.prototype.call=function(e,t){return t.subscribe(new jn(e,this.duration,this.scheduler,this.leading,this.trailing))},e}(),jn=function(e){function t(t,r,n,i,a){var o=e.call(this,t)||this;return o.duration=r,o.scheduler=n,o.leading=i,o.trailing=a,o._hasTrailingValue=!1,o._trailingValue=null,o}return n.a(t,e),t.prototype._next=function(e){this.throttled?this.trailing&&(this._trailingValue=e,this._hasTrailingValue=!0):(this.add(this.throttled=this.scheduler.schedule(Pn,this.duration,{subscriber:this})),this.leading?this.destination.next(e):this.trailing&&(this._trailingValue=e,this._hasTrailingValue=!0))},t.prototype._complete=function(){this._hasTrailingValue?(this.destination.next(this._trailingValue),this.destination.complete()):this.destination.complete()},t.prototype.clearThrottle=function(){var e=this.throttled;e&&(this.trailing&&this._hasTrailingValue&&(this.destination.next(this._trailingValue),this._trailingValue=null,this._hasTrailingValue=!1),e.unsubscribe(),this.remove(e),this.throttled=null)},t}(m.a);function Pn(e){e.subscriber.clearThrottle()}var En=r(306);function An(e){return void 0===e&&(e=u.a),function(t){return Object(En.a)((function(){return t.pipe(Ct((function(t,r){var n=t.current;return{value:r,current:e.now(),last:n}}),{current:e.now(),value:void 0,last:void 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e=this.action;e?this.action=e.schedule(this,this.waitFor):this.add(this.action=this.scheduler.schedule(t.dispatchTimeout,this.waitFor,this))},t.prototype._next=function(t){this.absoluteTimeout||this.scheduleTimeout(),e.prototype._next.call(this,t)},t.prototype._unsubscribe=function(){this.action=void 0,this.scheduler=null,this.withObservable=null},t}(i.b),Bn=r(303);function Vn(e,t){return void 0===t&&(t=u.a),In(e,Object(Bn.a)(new Tn.a),t)}function Rn(e){return void 0===e&&(e=u.a),Object(qe.a)((function(t){return new Ln(t,e.now())}))}var Ln=function(){return function(e,t){this.value=e,this.timestamp=t}}();function Nn(e,t,r){return 0===r?[t]:(e.push(t),e)}function Fn(){return At(Nn,[])}function Un(e){return function(t){return t.lift(new zn(e))}}var zn=function(){function e(e){this.windowBoundaries=e}return e.prototype.call=function(e,t){var r=new Hn(e),n=t.subscribe(r);return n.closed||r.add(Object(i.c)(this.windowBoundaries,new i.a(r))),n},e}(),Hn=function(e){function t(t){var r=e.call(this,t)||this;return r.window=new $t.a,t.next(r.window),r}return n.a(t,e),t.prototype.notifyNext=function(){this.openWindow()},t.prototype.notifyError=function(e){this._error(e)},t.prototype.notifyComplete=function(){this._complete()},t.prototype._next=function(e){this.window.next(e)},t.prototype._error=function(e){this.window.error(e),this.destination.error(e)},t.prototype._complete=function(){this.window.complete(),this.destination.complete()},t.prototype._unsubscribe=function(){this.window=null},t.prototype.openWindow=function(){var e=this.window;e&&e.complete();var t=this.destination,r=this.window=new $t.a;t.next(r)},t}(i.b);function Gn(e,t){return void 0===t&&(t=0),function(r){return r.lift(new qn(e,t))}}var qn=function(){function e(e,t){this.windowSize=e,this.startWindowEvery=t}return e.prototype.call=function(e,t){return t.subscribe(new Wn(e,this.windowSize,this.startWindowEvery))},e}(),Wn=function(e){function t(t,r,n){var i=e.call(this,t)||this;return i.destination=t,i.windowSize=r,i.startWindowEvery=n,i.windows=[new $t.a],i.count=0,t.next(i.windows[0]),i}return n.a(t,e),t.prototype._next=function(e){for(var t=this.startWindowEvery>0?this.startWindowEvery:this.windowSize,r=this.destination,n=this.windowSize,i=this.windows,a=i.length,o=0;o<a&&!this.closed;o++)i[o].next(e);var s=this.count-n+1;if(s>=0&&s%t==0&&!this.closed&&i.shift().complete(),++this.count%t==0&&!this.closed){var u=new $t.a;i.push(u),r.next(u)}},t.prototype._error=function(e){var t=this.windows;if(t)for(;t.length>0&&!this.closed;)t.shift().error(e);this.destination.error(e)},t.prototype._complete=function(){var e=this.windows;if(e)for(;e.length>0&&!this.closed;)e.shift().complete();this.destination.complete()},t.prototype._unsubscribe=function(){this.count=0,this.windows=null},t}(m.a);function Xn(e){var t=u.a,r=null,n=Number.POSITIVE_INFINITY;return Object(y.a)(arguments[3])&&(t=arguments[3]),Object(y.a)(arguments[2])?t=arguments[2]:Object($r.a)(arguments[2])&&(n=Number(arguments[2])),Object(y.a)(arguments[1])?t=arguments[1]:Object($r.a)(arguments[1])&&(r=Number(arguments[1])),function(i){return i.lift(new Yn(e,r,n,t))}}var Yn=function(){function e(e,t,r,n){this.windowTimeSpan=e,this.windowCreationInterval=t,this.maxWindowSize=r,this.scheduler=n}return e.prototype.call=function(e,t){return t.subscribe(new Kn(e,this.windowTimeSpan,this.windowCreationInterval,this.maxWindowSize,this.scheduler))},e}(),Qn=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t._numberOfNextedValues=0,t}return n.a(t,e),t.prototype.next=function(t){this._numberOfNextedValues++,e.prototype.next.call(this,t)},Object.defineProperty(t.prototype,"numberOfNextedValues",{get:function(){return this._numberOfNextedValues},enumerable:!0,configurable:!0}),t}($t.a),Kn=function(e){function t(t,r,n,i,a){var o=e.call(this,t)||this;o.destination=t,o.windowTimeSpan=r,o.windowCreationInterval=n,o.maxWindowSize=i,o.scheduler=a,o.windows=[];var s=o.openWindow();if(null!==n&&n>=0){var u={subscriber:o,window:s,context:null},c={windowTimeSpan:r,windowCreationInterval:n,subscriber:o,scheduler:a};o.add(a.schedule($n,r,u)),o.add(a.schedule(Jn,n,c))}else{var l={subscriber:o,window:s,windowTimeSpan:r};o.add(a.schedule(Zn,r,l))}return o}return n.a(t,e),t.prototype._next=function(e){for(var t=this.windows,r=t.length,n=0;n<r;n++){var i=t[n];i.closed||(i.next(e),i.numberOfNextedValues>=this.maxWindowSize&&this.closeWindow(i))}},t.prototype._error=function(e){for(var t=this.windows;t.length>0;)t.shift().error(e);this.destination.error(e)},t.prototype._complete=function(){for(var e=this.windows;e.length>0;){var t=e.shift();t.closed||t.complete()}this.destination.complete()},t.prototype.openWindow=function(){var e=new Qn;return 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s=(i=o,e.data.substring(e.indices[2*i],e.indices[2*i+1])),u=s.split(/\s+/);0===(m=parseInt(s[5])-1)&&(n=g.Mat4.identity(),a.push(n)),g.Mat4.setValue(n,m,0,parseFloat(u[2])),g.Mat4.setValue(n,m,1,parseFloat(u[3])),g.Mat4.setValue(n,m,2,parseFloat(u[4])),g.Mat4.setValue(n,m,3,parseFloat(u[5]))}if(0===a.length)return[];for(var c=[],l=1,d=0,f=a;d<f.length;d++){var p=f[d],m={id:"ncsop"+l++,code:".",details:"."};for(o=0;o<3;o++){for(var h=0;h<3;h++)m["matrix["+(o+1)+"]["+(h+1)+"]"]=""+g.Mat4.getValue(p,o,h);m["vector["+(o+1)+"]"]=""+g.Mat4.getValue(p,o,3)}c.push(m)}var v={id:oe.c.ofStrings(c.map((function(e){return e.id}))),code:oe.c.ofStrings(c.map((function(e){return e.code}))),details:oe.c.ofStrings(c.map((function(e){return e.details})))},b=function(e){for(var t=function(t){var r="matrix["+(e+1)+"]["+(t+1)+"]";v[r]=oe.c.ofStrings(c.map((function(e){return e[r]})))},r=0;r<3;r++)t(r);var n="vector["+(e+1)+"]";v[n]=oe.c.ofStrings(c.map((function(e){return e[n]})))};for(o=0;o<3;o++)b(o);return[oe.b.ofFields("struct_ncs_oper",v)]}var de={1:"HELX_RH_AL_P",2:"HELX_RH_OM_P",3:"HELX_RH_PI_P",4:"HELX_RH_GA_P",5:"HELX_RH_3T_P",6:"HELX_LH_AL_P",7:"HELX_LH_OM_P",8:"HELX_LH_GA_P",9:"HELX_RH_27_P",10:"HELX_RH_PP_P"};function fe(e,t,r){for(var n,i=[],a=t;a<r;a++){var o=(n=a,e.data.substring(e.indices[2*n],e.indices[2*n+1]));i.push({serNum:o.substr(7,3).trim(),helixID:o.substr(11,3).trim(),initResName:o.substr(15,3).trim(),initChainID:o.substr(19,1).trim(),initSeqNum:o.substr(21,4).trim(),initICode:o.substr(25,1).trim(),endResName:o.substr(27,3).trim(),endChainID:o.substr(31,3).trim(),endSeqNum:o.substr(33,4).trim(),endICode:o.substr(37,1).trim(),helixClass:o.substr(38,2).trim(),comment:o.substr(40,30).trim(),length:o.substr(71,5).trim()})}var s=oe.c.ofStrings(i.map((function(e){return e.initChainID}))),c=oe.c.ofStrings(i.map((function(e){return e.initResName}))),l=oe.c.ofStrings(i.map((function(e){return e.endChainID}))),d=oe.c.ofStrings(i.map((function(e){return e.endResName}))),f={beg_label_asym_id:s,beg_label_comp_id:c,beg_label_seq_id:oe.c.ofUndefined(i.length,u.a.Schema.int),beg_auth_asym_id:s,beg_auth_comp_id:c,beg_auth_seq_id:oe.c.ofStrings(i.map((function(e){return e.initSeqNum}))),conf_type_id:oe.c.ofStrings(i.map((function(e){return t=e.helixClass,de[t]||"HELX_P";var t}))),details:oe.c.ofStrings(i.map((function(e){return e.comment}))),end_label_asym_id:l,end_label_comp_id:d,end_label_seq_id:oe.c.ofUndefined(i.length,u.a.Schema.int),end_auth_asym_id:l,end_auth_comp_id:d,end_auth_seq_id:oe.c.ofStrings(i.map((function(e){return e.endSeqNum}))),id:oe.c.ofStrings(i.map((function(e){return e.serNum}))),pdbx_beg_PDB_ins_code:oe.c.ofStrings(i.map((function(e){return e.initICode}))),pdbx_end_PDB_ins_code:oe.c.ofStrings(i.map((function(e){return e.endICode}))),pdbx_PDB_helix_class:oe.c.ofStrings(i.map((function(e){return e.helixClass}))),pdbx_PDB_helix_length:oe.c.ofStrings(i.map((function(e){return e.length}))),pdbx_PDB_helix_id:oe.c.ofStrings(i.map((function(e){return e.helixID})))};return oe.b.ofFields("struct_conf",f)}function pe(e,t,r){for(var n,i=[],a=t;a<r;a++){var o=(n=a,e.data.substring(e.indices[2*n],e.indices[2*n+1]));i.push({strand:o.substr(7,3).trim(),sheetID:o.substr(11,3).trim(),numStrands:o.substr(14,2).trim(),initResName:o.substr(17,3).trim(),initChainID:o.substr(21,1).trim(),initSeqNum:o.substr(22,4).trim(),initICode:o.substr(26,1).trim(),endResName:o.substr(28,3).trim(),endChainID:o.substr(32,1).trim(),endSeqNum:o.substr(33,4).trim(),endICode:o.substr(37,1).trim(),sense:o.substr(38,2).trim(),curAtom:o.substr(41,4).trim(),curResName:o.substr(45,3).trim(),curChainId:o.substr(49,1).trim(),curResSeq:o.substr(50,4).trim(),curICode:o.substr(54,1).trim(),prevAtom:o.substr(56,4).trim(),prevResName:o.substr(60,3).trim(),prevChainId:o.substr(64,1).trim(),prevResSeq:o.substr(65,4).trim(),prevICode:o.substr(69,1).trim()})}var s=oe.c.ofStrings(i.map((function(e){return e.initChainID}))),u=oe.c.ofStrings(i.map((function(e){return e.initResName}))),c=oe.c.ofStrings(i.map((function(e){return e.initSeqNum}))),l=oe.c.ofStrings(i.map((function(e){return e.endChainID}))),d=oe.c.ofStrings(i.map((function(e){return e.endResName}))),f=oe.c.ofStrings(i.map((function(e){return e.endSeqNum}))),p={beg_label_asym_id:s,beg_label_comp_id:u,beg_label_seq_id:c,beg_auth_asym_id:s,beg_auth_comp_id:u,beg_auth_seq_id:c,end_label_asym_id:l,end_label_comp_id:l,end_label_seq_id:f,end_auth_asym_id:l,end_auth_comp_id:d,end_auth_seq_id:f,id:oe.c.ofStrings(i.map((function(e){return e.strand}))),sheet_id:oe.c.ofStrings(i.map((function(e){return e.sheetID}))),pdbx_beg_PDB_ins_code:oe.c.ofStrings(i.map((function(e){return e.initICode}))),pdbx_end_PDB_ins_code:oe.c.ofStrings(i.map((function(e){return e.endICode})))};return oe.b.ofFields("struct_sheet_range",p)}var me={MOL_ID:"",MOLECULE:"",CHAIN:"",FRAGMENT:"",SYNONYM:"",EC:"",ENGINEERED:"",MUTATION:"",OTHER_DETAILS:""};function he(e,t,r){for(var n,i,a={chains:[],description:""},o=[],s=t;s<r;s++){var u=(i=s,e.data.substring(e.indices[2*i],e.indices[2*i+1])).substr(10,70).trim(),c=u.indexOf(":"),l=u.substring(0,c),d=void 0;l in me?(n=l,d=u.substring(c+2)):d=u,d=d.replace(/;$/,""),"MOL_ID"===n?(a={chains:[],description:""},o.push(a)):"MOLECULE"===n?(a.description&&(a.description+=" "),a.description+=d):"CHAIN"===n&&Array.prototype.push.apply(a.chains,d.split(/\s*,\s*/))}return o}function ge(e,t,r){for(var n,i=new Map,a=t;a<r;a++){var o=(n=a,e.data.substring(e.indices[2*n],e.indices[2*n+1])),s=o.substr(11,3).trim(),u=o.substr(15).trim();i.has(s)?i.set(s,i.get(s)+" "+u):i.set(s,u)}return i}function ve(e,t,r,n,i,a){var o=r.data,s=i-n;c.a.addToken(e.group_PDB,c.b.trim(r,n,n+6)),c.b.trim(r,n+6,n+11),e.id[e.index]=r.data.substring(r.tokenStart,r.tokenEnd),c.a.addToken(e.auth_atom_id,c.b.trim(r,n+12,n+16)),32===o.charCodeAt(n+16)?c.a.add(e.label_alt_id,0,0):c.a.add(e.label_alt_id,n+16,n+17),c.a.addToken(e.auth_comp_id,c.b.trim(r,n+17,n+20)),c.a.add(e.auth_asym_id,n+21,n+22),c.a.addToken(e.auth_seq_id,c.b.trim(r,n+22,n+26)),32===o.charCodeAt(n+26)?c.a.add(e.pdbx_PDB_ins_code,0,0):c.a.add(e.pdbx_PDB_ins_code,n+26,n+27),c.a.addToken(e.Cartn_x,c.b.trim(r,n+30,n+38)),c.a.addToken(e.Cartn_y,c.b.trim(r,n+38,n+46)),c.a.addToken(e.Cartn_z,c.b.trim(r,n+46,n+54)),c.a.addToken(e.occupancy,c.b.trim(r,n+54,n+60)),s>=66?c.a.addToken(e.B_iso_or_equiv,c.b.trim(r,n+60,n+66)):c.a.add(e.B_iso_or_equiv,0,0),a&&c.a.addToken(e.partial_charge,c.b.trim(r,n+70,n+76)),s>=78&&!a?(c.b.trim(r,n+76,n+78),r.tokenStart<r.tokenEnd?c.a.addToken(e.type_symbol,r):N(e.type_symbol,o,n+12,n+16)):N(e.type_symbol,o,n+12,n+16),e.pdbx_PDB_model_num[e.index]=t,e.index++}function be(e){var t=oe.c.ofTokens(e.pdbx_auth_seq_id),r=oe.c.ofTokens(e.pdbx_auth_comp_id),n=oe.c.ofTokens(e.pdbx_auth_asym_id),i=oe.c.ofTokens(e.pdbx_auth_atom_id),a={id:oe.c.ofStrings(e.id),type_symbol:oe.c.ofTokens(e.type_symbol),pdbx_label_atom_id:i,pdbx_label_alt_id:oe.c.ofTokens(e.pdbx_label_alt_id),pdbx_label_comp_id:r,pdbx_label_asym_id:n,pdbx_label_seq_id:t,pdbx_PDB_ins_code:oe.c.ofTokens(e.pdbx_PDB_ins_code),pdbx_auth_seq_id:t,pdbx_auth_comp_id:r,pdbx_auth_asym_id:n,pdbx_auth_atom_id:i};return a["U[1][1]"]=oe.c.ofNumbers(e["U[1][1]"]),a["U[2][2]"]=oe.c.ofNumbers(e["U[2][2]"]),a["U[3][3]"]=oe.c.ofNumbers(e["U[3][3]"]),a["U[1][2]"]=oe.c.ofNumbers(e["U[1][2]"]),a["U[1][3]"]=oe.c.ofNumbers(e["U[1][3]"]),a["U[2][3]"]=oe.c.ofNumbers(e["U[2][3]"]),a}function ye(e,t,r,n,i){var a=r.data,o=i-n;c.b.trim(r,n+6,n+11),e.id[e.index]=a.substring(r.tokenStart,r.tokenEnd),c.a.addToken(e.pdbx_auth_atom_id,c.b.trim(r,n+12,n+16)),32===a.charCodeAt(n+16)?c.a.add(e.pdbx_label_alt_id,0,0):c.a.add(e.pdbx_label_alt_id,n+16,n+17),c.a.addToken(e.pdbx_auth_comp_id,c.b.trim(r,n+17,n+20)),c.a.add(e.pdbx_auth_asym_id,n+21,n+22),c.a.addToken(e.pdbx_auth_seq_id,c.b.trim(r,n+22,n+26)),32===a.charCodeAt(n+26)?c.a.add(e.pdbx_PDB_ins_code,0,0):c.a.add(e.pdbx_PDB_ins_code,n+26,n+27),e["U[1][1]"][e.index]=Object(l.e)(a,n+28,n+35)/1e4,e["U[2][2]"][e.index]=Object(l.e)(a,n+35,n+42)/1e4,e["U[3][3]"][e.index]=Object(l.e)(a,n+42,n+49)/1e4,e["U[1][2]"][e.index]=Object(l.e)(a,n+49,n+56)/1e4,e["U[1][3]"][e.index]=Object(l.e)(a,n+56,n+63)/1e4,e["U[2][3]"][e.index]=Object(l.e)(a,n+63,n+70)/1e4,o>=78?(c.b.trim(r,n+76,n+78),r.tokenStart<r.tokenEnd?c.a.addToken(e.type_symbol,r):N(e.type_symbol,a,n+12,n+16)):N(e.type_symbol,a,n+12,n+16),e.index++}var _e=r(48);function Se(e){return Object(n.__awaiter)(this,void 0,void 0,(function(){var t,r,i,a,o,s,l,d,f,p,m,h,g,v,b,y,_,S,x,O,w,C,P,E,A,D,T,I,M,k,B,V,R;return Object(n.__generator)(this,(function(n){for(t=e.lines,r=t.data,i=t.indices,a=Object(c.b)(r),o=!!e.isPdbqt,s=0,l=0,A=0,y=t.count;A<y;A++)switch(_=i[2*A],S=i[2*A+1],r[_]){case"A":Object(j.f)(r,_,S,"ATOM  ")?s++:Object(j.f)(r,_,S,"ANISOU")&&l++;break;case"H":Object(j.f)(r,_,S,"HETATM")&&s++}for(d=function(e,t){var r=function(){return c.a.create(e,2*t)};return{index:0,group_PDB:r(),id:[],auth_atom_id:r(),label_alt_id:r(),auth_comp_id:r(),auth_asym_id:r(),auth_seq_id:r(),pdbx_PDB_ins_code:r(),Cartn_x:r(),Cartn_y:r(),Cartn_z:r(),occupancy:r(),B_iso_or_equiv:r(),type_symbol:r(),pdbx_PDB_model_num:[],label_entity_id:[],partial_charge:r()}}(r,s),f=function(e,t){var r=function(){return new Float32Array(t)},n=function(){return c.a.create(e,2*t)};return{index:0,count:t,id:[],type_symbol:n(),pdbx_label_atom_id:n(),pdbx_label_alt_id:n(),pdbx_label_comp_id:n(),pdbx_label_asym_id:n(),pdbx_label_seq_id:n(),pdbx_PDB_ins_code:n(),"U[1][1]":r(),"U[2][2]":r(),"U[3][3]":r(),"U[1][2]":r(),"U[1][3]":r(),"U[2][3]":r(),pdbx_auth_seq_id:n(),pdbx_auth_comp_id:n(),pdbx_auth_asym_id:n(),pdbx_auth_atom_id:n()}}(r,l),p=new te,m=[],h=[],g=0,v="",b=void 0,A=0,y=t.count;A<y;A++)switch(_=i[2*A],S=i[2*A+1],r[_]){case"A":Object(j.f)(r,_,S,"ATOM  ")?(g||(g++,v=""+g),ve(d,v,a,_,S,o)):Object(j.f)(r,_,S,"ANISOU")&&ye(f,0,a,_,S);break;case"C":if(Object(j.f)(r,_,S,"CRYST1"))m.push.apply(m,se(e.id||"?",r.substring(_,S)));else if(Object(j.f)(r,_,S,"CONECT")){for(x=A+1;_=i[2*x],S=i[2*x+1],Object(j.f)(r,_,S,"CONECT");)x++;b?_e.a&&console.log("only single CONECT block allowed, ignoring others"):b=[A,x],A=x-1}else if(Object(j.f)(r,_,S,"COMPND")){for(x=A+1;_=i[2*x],S=i[2*x+1],Object(j.f)(r,_,S,"COMPND");)x++;p.setCompounds(he(t,A,x)),A=x-1}break;case"H":if(Object(j.f)(r,_,S,"HETATM"))g||(g++,v=""+g),ve(d,v,a,_,S,o);else if(Object(j.f)(r,_,S,"HELIX")){for(x=A+1;_=i[2*x],S=i[2*x+1],Object(j.f)(r,_,S,"HELIX");)x++;m.push(fe(t,A,x)),A=x-1}else if(Object(j.f)(r,_,S,"HETNAM")){for(x=A+1;_=i[2*x],S=i[2*x+1],Object(j.f)(r,_,S,"HETNAM");)x++;h.push.apply(h,Array.from(ge(t,A,x).entries())),A=x-1}break;case"M":if(Object(j.f)(r,_,S,"MODEL ")&&(g++,v=""+g),Object(j.f)(r,_,S,"MTRIX")){for(x=A+1;_=i[2*x],S=i[2*x+1],Object(j.f)(r,_,S,"MTRIX");)x++;m.push.apply(m,le(t,A,x)),A=x-1}break;case"O":break;case"R":if(Object(j.f)(r,_,S,"REMARK 350")){for(x=A+1;_=i[2*x],S=i[2*x+1],Object(j.f)(r,_,S,"REMARK 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L,N,F,U;for(L=d,N=oe.c.ofTokens(L.auth_asym_id),F=oe.c.ofTokens(L.auth_atom_id),U=oe.c.ofTokens(L.auth_comp_id),M={auth_asym_id:N,auth_atom_id:F,auth_comp_id:U,auth_seq_id:oe.c.ofTokens(L.auth_seq_id),B_iso_or_equiv:oe.c.ofTokens(L.B_iso_or_equiv),Cartn_x:oe.c.ofTokens(L.Cartn_x),Cartn_y:oe.c.ofTokens(L.Cartn_y),Cartn_z:oe.c.ofTokens(L.Cartn_z),group_PDB:oe.c.ofTokens(L.group_PDB),id:oe.c.ofStrings(L.id),label_alt_id:oe.c.ofTokens(L.label_alt_id),label_asym_id:N,label_atom_id:F,label_comp_id:U,label_seq_id:oe.c.ofUndefined(L.index,u.a.Schema.int),label_entity_id:oe.c.ofStrings(L.label_entity_id),occupancy:oe.c.ofTokens(L.occupancy),type_symbol:oe.c.ofTokens(L.type_symbol),pdbx_PDB_ins_code:oe.c.ofTokens(L.pdbx_PDB_ins_code),pdbx_PDB_model_num:oe.c.ofStrings(L.pdbx_PDB_model_num),partial_charge:oe.c.ofTokens(L.partial_charge)},o||delete M.partial_charge,b&&m.push(function(e,t,r,n){for(var i={},a=0,o=n.id.rowCount;a<o;++a)i[n.id.str(a)]=a;var s,u=[],c=[],l=[],d=[],f=[],p=[],m=[],h=[],g=[],v=[],b=[11,16,21,26],y=1;for(a=t;a<r;a++){var _=(s=a,e.data.substring(e.indices[2*s],e.indices[2*s+1])),S=i[parseInt(_.substr(6,5))],x={};if(void 0!==S)for(var O=0;O<4;++O){var w=parseInt(_.substr(b[O],5));if(!Number.isNaN(w)){var C=i[w];void 0!==C&&(S>C||void 0===x[C]&&(u.push("covale"+y),c.push("covale"),l.push(n.label_asym_id.str(S)),f.push(n.auth_seq_id.int(S)),d.push(n.label_seq_id.int(S)),p.push(n.label_atom_id.str(S)),m.push(n.label_asym_id.str(C)),g.push(n.auth_seq_id.int(C)),h.push(n.label_seq_id.int(C)),v.push(n.label_atom_id.str(C)),y+=1))}}}var j={id:oe.c.ofStrings(u),conn_type_id:oe.c.ofStrings(c),ptnr1_label_asym_id:oe.c.ofStrings(l),ptnr1_auth_seq_id:oe.c.ofNumbers(f),ptnr1_label_seq_id:oe.c.ofNumbers(d),ptnr1_label_atom_id:oe.c.ofStrings(p),ptnr2_label_asym_id:oe.c.ofStrings(m),ptnr2_label_seq_id:oe.c.ofNumbers(h),ptnr2_auth_seq_id:oe.c.ofNumbers(g),ptnr2_label_atom_id:oe.c.ofStrings(v)};return oe.b.ofFields("struct_conn",j)}(t,b[0],b[1],M)),k={entity:oe.b.ofTable("entity",p.getEntityTable()),chem_comp:oe.b.ofTable("chem_comp",E.getChemCompTable()),atom_site:oe.b.ofFields("atom_site",M),atom_site_anisotrop:oe.b.ofFields("atom_site_anisotrop",be(f))},B=0,V=m;B<V.length;B++)R=V[B],k[R.name]=R;return[2,{header:e.id||"PDB",categoryNames:Object.keys(k),categories:k}]}))}))}var xe,Oe=r(289);function we(e){var t=this;return a.b.create("Parse PDB",(function(r){return Object(n.__awaiter)(t,void 0,void 0,(function(){var t,i,a,o,s,c,l,d,f,p,m;return Object(n.__generator)(this,(function(n){switch(n.label){case 0:return[4,r.update("Converting to mmCIF")];case 1:return n.sent(),[4,Se(e)];case 2:return t=n.sent(),i=ae.a.fromFrame(t,void 0,xe.create(e)),[4,Object(re.a)(i.data.db,i,r)];case 3:return a=n.sent(),(o=null===(m=t.categories.atom_site)||void 0===m?void 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b=e.residueId.value(g),y=e.segmentName.value(g);if(f!==y?(l=ee(c),c+=1,d=0,p=!0,f=y):p=!1,p||b!==h){var _=e.residueName.value(g),S=Object(H.getMoleculeType)(o.add(_,g).type,_);p||S===m&&b===h+1||(l=ee(c),c+=1,d=0),s=a.getEntityId(_,S,l),d+=1,h=b,m=S}t[g]=s,r[g]=l,n[g]=d,i[g]=g}var x=u.d.ofPartialColumns(q.a.atom_site,{auth_asym_id:e.segmentName,auth_atom_id:e.atomName,auth_comp_id:e.residueName,auth_seq_id:e.residueId,id:u.a.ofIntArray(i),label_asym_id:u.a.ofStringArray(r),label_atom_id:e.atomName,label_comp_id:e.residueName,label_seq_id:u.a.ofIntArray(n),label_entity_id:u.a.ofStringArray(t),occupancy:u.a.ofConst(1,e.count,u.a.Schema.float),type_symbol:u.a.ofStringArray(u.a.mapToArray(e.atomName,(function(e){return U(e)}))),pdbx_PDB_model_num:u.a.ofConst(1,e.count,u.a.Schema.int)},e.count);return Object(q.b)({entity:a.getEntityTable(),chem_comp:o.getChemCompTable(),atom_site:x})}(e.atoms),i=e.bonds,a=i.atomIdA,o=i.atomIdB,s={indexA:u.a.ofLambda({value:function(e){return 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Object(n.__generator)(this,(function(n){switch(n.label){case 0:return[4,s(r.data).runInContext(e)];case 1:if((t=n.sent()).isError)throw new Error(t.message);return[4,L(t.result).runInContext(e)];case 2:return i=n.sent(),[2,new Ve.a.Molecule.Coordinates(i,{label:r.label,description:"Coordinates"})]}}))}))}))}}),bt=Ve.b.BuiltIn({name:"coordinates-from-xtc",display:{name:"Parse XTC",description:"Parse XTC binary data."},from:[Ve.a.Data.Binary],to:Ve.a.Molecule.Coordinates})({apply:function(e){var t=this,r=e.a;return a.b.create("Parse XTC",(function(e){return Object(n.__awaiter)(t,void 0,void 0,(function(){var t,i;return Object(n.__generator)(this,(function(n){switch(n.label){case 0:return[4,ht(r.data).runInContext(e)];case 1:if((t=n.sent()).isError)throw new Error(t.message);return[4,gt(t.result).runInContext(e)];case 2:return i=n.sent(),[2,new Ve.a.Molecule.Coordinates(i,{label:r.label,description:"Coordinates"})]}}))}))}))}}),yt=Ve.b.BuiltIn({name:"topology-from-psf",display:{name:"PSF 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St=Ve.b.BuiltIn({name:"trajectory-from-model-and-coordinates",display:{name:"Trajectory from Topology & Coordinates",description:"Create a trajectory from existing model/topology and coordinates."},from:Ve.a.Root,to:Ve.a.Molecule.Trajectory,params:{modelRef:O.ParamDefinition.Text("",{isHidden:!0}),coordinatesRef:O.ParamDefinition.Text("",{isHidden:!0})}})({apply:function(e){var t=this,r=e.params,i=e.dependencies;return a.b.create("Create trajectory from model/topology and coordinates",(function(e){return Object(n.__awaiter)(t,void 0,void 0,(function(){var t,a,o;return Object(n.__generator)(this,(function(n){switch(n.label){case 0:return t=i[r.coordinatesRef].data,[4,_t(e,i[r.modelRef],t)];case 1:return a=n.sent(),o={label:"Trajectory",description:a.frameCount+" model"+(1===a.frameCount?"":"s")},[2,new Ve.a.Molecule.Trajectory(a,o)]}}))}))}))}}),xt=Ve.b.BuiltIn({name:"trajectory-from-blob",display:{name:"Parse Blob",description:"Parse format blob into a single trajectory."},from:Ve.a.Format.Blob,to:Ve.a.Molecule.Trajectory})({apply:function(e){var t=this,r=e.a;return a.b.create("Parse Format Blob",(function(e){return Object(n.__awaiter)(t,void 0,void 0,(function(){var t,i,o,s,u,c,l,d,f;return Object(n.__generator)(this,(function(n){switch(n.label){case 0:t=[],i=0,o=r.data,n.label=1;case 1:return i<o.length?"cif"!==(s=o[i]).kind?[3,6]:(u=s.data.blocks[0],[4,Object(ae.b)(u).runInContext(e)]):[3,7];case 2:if(0===(c=n.sent()).frameCount)throw new Error("No models found.");d=0,n.label=3;case 3:return d<c.frameCount?[4,a.b.resolveInContext(c.getFrameAtIndex(d),e)]:[3,6];case 4:l=n.sent(),t.push(l),n.label=5;case 5:return d++,[3,3];case 6:return i++,[3,1];case 7:for(d=0;d<t.length;d++)Ae.Model.TrajectoryInfo.set(t[d],{index:d,size:t.length});return f={label:"Trajectory",description:t.length+" model"+(1===t.length?"":"s")},[2,new Ve.a.Molecule.Trajectory(new Ae.ArrayTrajectory(t),f)]}}))}))}))}});function Ot(e){return{label:""+e.representative.entry,description:e.frameCount+" model"+(1===e.frameCount?"":"s")}}var wt=Ve.b.BuiltIn({name:"trajectory-from-mmcif",display:{name:"Trajectory from mmCIF",description:"Identify and create all separate models in the specified CIF data block"},from:Ve.a.Format.Cif,to:Ve.a.Molecule.Trajectory,params:function(e){if(!e)return{blockHeader:O.ParamDefinition.Optional(O.ParamDefinition.Text(void 0,{description:"Header of the block to parse. 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If none is specifed, the 1st data block in the file is used."}))};var t=e.data.blocks;return{blockHeader:O.ParamDefinition.Optional(O.ParamDefinition.Select(t[0]&&t[0].header,t.map((function(e){return[e.header,e.header]})),{description:"Header of the block to parse"}))}}})({apply:function(e){var t=this,r=e.a,i=e.params;return a.b.create("Parse CIF Core",(function(e){return Object(n.__awaiter)(t,void 0,void 0,(function(){var t,o,s,u;return Object(n.__generator)(this,(function(n){switch(n.label){case 0:if(t=i.blockHeader||r.data.blocks[0].header,!(o=r.data.blocks.find((function(e){return e.header===t}))))throw new Error("Data block '"+[t]+"' not found.");return[4,(c=o,l=qe.fromFrame(c),a.b.create("Parse CIF Core",(function(e){return Ze(l.data.db,l,e)}))).runInContext(e)];case 1:if(0===(s=n.sent()).frameCount)throw new Error("No models found.");return u=Ot(s),[2,new Ve.a.Molecule.Trajectory(s,u)]}var c,l}))}))}))}}),Tt=function(e){return e+1},It=function(e){return e-1},Mt=Ve.b.BuiltIn({name:"model-from-trajectory",display:{name:"Molecular Model",description:"Create a molecular model from specified index in a trajectory."},from:Ve.a.Molecule.Trajectory,to:Ve.a.Molecule.Model,params:function(e){return e?{modelIndex:O.ParamDefinition.Converted(Tt,It,O.ParamDefinition.Numeric(1,{min:1,max:e.data.frameCount,step:1},{description:"Model Index"}))}:{modelIndex:O.ParamDefinition.Numeric(0,{},{description:"Zero-based index of the model"})}}})({isApplicable:function(e){return e.data.frameCount>0},apply:function(e){var t=this,r=e.a,i=e.params;return a.b.create("Model from Trajectory",(function(e){return Object(n.__awaiter)(t,void 0,void 0,(function(){var t,o,s,u;return Object(n.__generator)(this,(function(n){switch(n.label){case 0:return(t=i.modelIndex%r.data.frameCount)<0&&(t+=r.data.frameCount),[4,a.b.resolveInContext(r.data.getFrameAtIndex(t),e)];case 1:return o=n.sent(),s="Model "+(t+1),u=1===r.data.frameCount?void 0:"of "+r.data.frameCount,[2,new Ve.a.Molecule.Model(o,{label:s,description:u})]}}))}))}))},dispose:function(e){var t=e.b;null==t||t.data.customProperties.dispose()}}),kt=Ve.b.BuiltIn({name:"structure-from-trajectory",display:{name:"Structure from Trajectory",description:"Create a molecular structure from a trajectory."},from:Ve.a.Molecule.Trajectory,to:Ve.a.Molecule.Structure})({apply:function(e){var t=this,r=e.a;return a.b.create("Build Structure",(function(e){return Object(n.__awaiter)(t,void 0,void 0,(function(){var t,i;return Object(n.__generator)(this,(function(n){switch(n.label){case 0:return[4,Ae.Structure.ofTrajectory(r.data,e)];case 1:return t=n.sent(),i={label:"Ensemble",description:Ae.Structure.elementDescription(t)},[2,new Ve.a.Molecule.Structure(t,i)]}}))}))}))},dispose:function(e){var t=e.b;null==t||t.data.customPropertyDescriptors.dispose()}}),Bt=Ve.b.BuiltIn({name:"structure-from-model",display:{name:"Structure",description:"Create a molecular structure (model, assembly, or symmetry) from the specified model."},from:Ve.a.Molecule.Model,to:Ve.a.Molecule.Structure,params:function(e){return ke.a.getParams(e&&e.data)}})({canAutoUpdate:function(e){var t=e.oldParams,r=e.newParams;return ke.a.canAutoUpdate(t.type,r.type)},apply:function(e,t){var r=this,i=e.a,o=e.params;return a.b.create("Build Structure",(function(e){return Object(n.__awaiter)(r,void 0,void 0,(function(){return Object(n.__generator)(this,(function(r){return[2,ke.a.create(t,e,i.data,o&&o.type)]}))}))}))},update:function(e){var t=e.a,r=e.b,n=e.oldParams,i=e.newParams;return Object(Me.g)(n,i)?r.data.model===t.data?Ie.StateTransformer.UpdateResult.Unchanged:Ae.Model.areHierarchiesEqual(t.data,r.data.model)?(r.data=r.data.remapModel(t.data),Ie.StateTransformer.UpdateResult.Updated):Ie.StateTransformer.UpdateResult.Recreate:Ie.StateTransformer.UpdateResult.Recreate},dispose:function(e){var t=e.b;null==t||t.data.customPropertyDescriptors.dispose()}}),Vt=Object(g.Vec3)(),Rt=Object(g.Mat4)(),Lt=Object(g.Mat4)(),Nt=Ve.b.BuiltIn({name:"transform-structure-conformation",display:{name:"Transform Conformation"},isDecorator:!0,from:Ve.a.Molecule.Structure,to:Ve.a.Molecule.Structure,params:{transform:O.ParamDefinition.MappedStatic("components",{components:O.ParamDefinition.Group({axis:O.ParamDefinition.Vec3(g.Vec3.create(1,0,0)),angle:O.ParamDefinition.Numeric(0,{min:-180,max:180,step:.1}),translation:O.ParamDefinition.Vec3(g.Vec3.create(0,0,0))},{isFlat:!0}),matrix:O.ParamDefinition.Group({data:O.ParamDefinition.Mat4(g.Mat4.identity()),transpose:O.ParamDefinition.Boolean(!1)},{isFlat:!0})},{label:"Kind"})}})({canAutoUpdate:function(e){return"matrix"!==e.newParams.transform.name},apply:function(e){var t=e.a,r=e.params,n=Object(g.Mat4)();if("components"===r.transform.name){var i=r.transform.params,a=i.axis,o=i.angle,s=i.translation,u=t.data.boundary.sphere.center;g.Mat4.fromTranslation(Rt,g.Vec3.negate(Vt,u)),g.Mat4.fromTranslation(Lt,g.Vec3.add(Vt,u,s));var c=g.Mat4.fromRotation(Object(g.Mat4)(),Math.PI/180*o,g.Vec3.normalize(Object(g.Vec3)(),a));g.Mat4.mul3(n,Lt,c,Rt)}else"matrix"===r.transform.name&&(g.Mat4.copy(n,r.transform.params.data),r.transform.params.transpose&&g.Mat4.transpose(n,n));var l=Ae.Structure.transform(t.data,n);return new Ve.a.Molecule.Structure(l,{label:t.label,description:t.description+" [Transformed]"})},dispose:function(e){var t=e.b;null==t||t.data.customPropertyDescriptors.dispose()}}),Ft=Ve.b.BuiltIn({name:"structure-selection-from-expression",display:{name:"Selection",description:"Create a molecular structure from the specified expression."},from:Ve.a.Molecule.Structure,to:Ve.a.Molecule.Structure,params:{expression:O.ParamDefinition.Value(De.MolScriptBuilder.struct.generator.all,{isHidden:!0}),label:O.ParamDefinition.Optional(O.ParamDefinition.Text("",{isHidden:!0}))}})({apply:function(e){var t=e.a,r=e.params,n=e.cache,i=Ee.createAndRun(t.data,r.expression),a=i.selection,o=i.entry;if(n.entry=o,Ae.StructureSelection.isEmpty(a))return Ie.StateObject.Null;var s=Ae.StructureSelection.unionStructure(a),u={label:""+(r.label||"Selection"),description:Ae.Structure.elementDescription(s)};return new Ve.a.Molecule.Structure(s,u)},update:function(e){var t=e.a,r=e.b,n=e.oldParams,i=e.newParams,a=e.cache;if(n.expression!==i.expression)return Ie.StateTransformer.UpdateResult.Recreate;var o=a.entry;if(o.currentStructure===t.data)return Ie.StateTransformer.UpdateResult.Unchanged;var s=Ee.updateStructure(o,t.data);return Ae.StructureSelection.isEmpty(s)?Ie.StateTransformer.UpdateResult.Null:(Ee.updateStructureObject(r,s,i.label),Ie.StateTransformer.UpdateResult.Updated)},dispose:function(e){var t=e.b;null==t||t.data.customPropertyDescriptors.dispose()}}),Ut=Ve.b.BuiltIn({name:"structure-multi-selection-from-expression",display:{name:"Multi-structure Measurement Selection",description:"Create selection object from multiple structures."},from:Ve.a.Root,to:Ve.a.Molecule.Structure.Selections,params:{selections:O.ParamDefinition.ObjectList({key:O.ParamDefinition.Text(void 0,{description:"A unique key."}),ref:O.ParamDefinition.Text(),groupId:O.ParamDefinition.Optional(O.ParamDefinition.Text()),expression:O.ParamDefinition.Value(De.MolScriptBuilder.struct.generator.empty)},(function(e){return e.ref}),{isHidden:!0}),isTransitive:O.ParamDefinition.Optional(O.ParamDefinition.Boolean(!1,{isHidden:!0,description:"Remap the selections from the original structure if structurally equivalent."})),label:O.ParamDefinition.Optional(O.ParamDefinition.Text("",{isHidden:!0}))}})({apply:function(e){for(var t=e.params,r=e.cache,n=e.dependencies,i=new Map,a=[],o=0,s=0,u=t.selections;s<u.length;s++){var c=u[s],l=Ee.createAndRun(n[c.ref].data,c.expression),d=l.selection,f=l.entry;i.set(c.key,f);var p=Ae.StructureSelection.toLociWithSourceUnits(d);a.push({key:c.key,loci:p,groupId:c.groupId}),o+=Ae.StructureElement.Loci.size(p)}r.entries=i;var m={label:""+(t.label||"Multi-selection"),description:t.selections.length+" source(s), "+o+" element(s) total"};return new Ve.a.Molecule.Structure.Selections(a,m)},update:function(e){var t=e.b,r=e.oldParams,n=e.newParams,i=e.cache,a=e.dependencies;if(!!r.isTransitive!=!!n.isTransitive)return Ie.StateTransformer.UpdateResult.Recreate;for(var o=i.entries,s=new Map,u=new Map,c=0,l=t.data;c<l.length;c++){var d=l[c];u.set(d.key,d)}for(var f=!1,p=0,m=[],h=0,g=n.selections;h<g.length;h++){var v=g[h],b=a[v.ref].data,y=!1;if(o.has(v.key)){var _=o.get(v.key);if(Ee.isUnchanged(_,v.expression,b)&&u.has(v.key)){(O=u.get(v.key)).groupId!==v.groupId&&(O.groupId=v.groupId,f=!0),s.set(v.key,_),m.push(O),p+=Ae.StructureElement.Loci.size(O.loci);continue}if(_.expression!==v.expression)y=!0;else{var S=!1;if(n.isTransitive)if(Ae.Structure.areUnitIdsAndIndicesEqual(_.originalStructure,b)){var x=Ee.run(_,_.originalStructure);_.currentStructure=b,s.set(v.key,_);var O=Ae.StructureElement.Loci.remap(Ae.StructureSelection.toLociWithSourceUnits(x),b);m.push({key:v.key,loci:O,groupId:v.groupId}),p+=Ae.StructureElement.Loci.size(O),f=!0}else S=!0;else S=!0;if(S){f=!0;x=Ee.updateStructure(_,b);s.set(v.key,_);O=Ae.StructureSelection.toLociWithSourceUnits(x);m.push({key:v.key,loci:O,groupId:v.groupId}),p+=Ae.StructureElement.Loci.size(O)}}}else y=!0;if(y){f=!0;var w=Ee.createAndRun(b,v.expression);x=w.selection,_=w.entry;s.set(v.key,_);O=Ae.StructureSelection.toLociWithSourceUnits(x);m.push({key:v.key,loci:O}),p+=Ae.StructureElement.Loci.size(O)}}return f?(i.entries=s,t.data=m,t.label=""+(n.label||"Multi-selection"),t.description=m.length+" source(s), "+p+" element(s) total",Ie.StateTransformer.UpdateResult.Updated):Ie.StateTransformer.UpdateResult.Unchanged}}),zt=Ve.b.BuiltIn({name:"structure-selection-from-script",display:{name:"Selection",description:"Create a molecular structure from the specified script."},from:Ve.a.Molecule.Structure,to:Ve.a.Molecule.Structure,params:{script:O.ParamDefinition.Script({language:"mol-script",expression:"(sel.atom.atom-groups :residue-test (= atom.resname ALA))"}),label:O.ParamDefinition.Optional(O.ParamDefinition.Text(""))}})({apply:function(e){var t=e.a,r=e.params,n=e.cache,i=Ee.createAndRun(t.data,r.script),a=i.selection,o=i.entry;n.entry=o;var s=Ae.StructureSelection.unionStructure(a),u={label:""+(r.label||"Selection"),description:Ae.Structure.elementDescription(s)};return new Ve.a.Molecule.Structure(s,u)},update:function(e){var t=e.a,r=e.b,n=e.oldParams,i=e.newParams,a=e.cache;if(!Te.Script.areEqual(n.script,i.script))return Ie.StateTransformer.UpdateResult.Recreate;var o=a.entry;if(o.currentStructure===t.data)return Ie.StateTransformer.UpdateResult.Unchanged;var s=Ee.updateStructure(o,t.data);return Ee.updateStructureObject(r,s,i.label),Ie.StateTransformer.UpdateResult.Updated},dispose:function(e){var t=e.b;null==t||t.data.customPropertyDescriptors.dispose()}}),Ht=Ve.b.BuiltIn({name:"structure-selection-from-bundle",display:{name:"Selection",description:"Create a molecular structure from the specified structure-element bundle."},from:Ve.a.Molecule.Structure,to:Ve.a.Molecule.Structure,params:{bundle:O.ParamDefinition.Value(Ae.StructureElement.Bundle.Empty,{isHidden:!0}),label:O.ParamDefinition.Optional(O.ParamDefinition.Text("",{isHidden:!0}))}})({apply:function(e){var t=e.a,r=e.params,n=e.cache;if(r.bundle.hash!==t.data.hashCode)return Ie.StateObject.Null;n.source=t.data;var i=Ae.StructureElement.Bundle.toStructure(r.bundle,t.data);if(0===i.elementCount)return Ie.StateObject.Null;var a={label:""+(r.label||"Selection"),description:Ae.Structure.elementDescription(i)};return new Ve.a.Molecule.Structure(i,a)},update:function(e){var t=e.a,r=e.b,n=e.oldParams,i=e.newParams,a=e.cache;if(!Ae.StructureElement.Bundle.areEqual(n.bundle,i.bundle))return Ie.StateTransformer.UpdateResult.Recreate;if(i.bundle.hash!==t.data.hashCode)return Ie.StateTransformer.UpdateResult.Null;if(a.source===t.data)return Ie.StateTransformer.UpdateResult.Unchanged;a.source=t.data;var o=Ae.StructureElement.Bundle.toStructure(i.bundle,t.data);return 0===o.elementCount?Ie.StateTransformer.UpdateResult.Null:(r.label=""+(i.label||"Selection"),r.description=Ae.Structure.elementDescription(o),r.data=o,Ie.StateTransformer.UpdateResult.Updated)},dispose:function(e){var t=e.b;null==t||t.data.customPropertyDescriptors.dispose()}}),Gt={polymer:"polymer",protein:"protein",nucleic:"nucleic",water:"water",branched:"branched",ligand:"ligand","non-standard":"non-standard",coarse:"coarse","atomic-sequence":"atomic-sequence","atomic-het":"atomic-het",spheres:"spheres"},qt=O.ParamDefinition.objectToOptions(Gt),Wt=Ve.b.BuiltIn({name:"structure-complex-element",display:{name:"Complex Element",description:"Create a molecular structure from the specified model."},from:Ve.a.Molecule.Structure,to:Ve.a.Molecule.Structure,params:{type:O.ParamDefinition.Select("atomic-sequence",qt,{isHidden:!0})}})({apply:function(e){var 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i=[[0,0,0,0,0],[4,4,8,4,0],[4,5,16,8,0],[4,6,16,16,0],[4,10,16,32,0],[8,16,32,32,0],[8,16,128,128,0],[8,32,128,256,0],[32,128,258,1024,1],[32,258,258,4096,1]][n],a=0,o=r<<3,s=0,u=e.length;if(0===n){for(;a<u;){R(t,o,a+(S=Math.min(65535,u-a))===u?1:0),o=T(e,a,S,t,o+8),a+=S}return o>>>3}var c=m.lits,l=m.strt,d=m.prev,f=0,p=0,h=0,g=0,v=0,b=0;for(u>2&&(l[b=A(e,0)]=0),a=0;a<u;a++){if(v=b,a+1<u-2){b=A(e,a+1);var y=a+1&32767;d[y]=l[b],l[b]=y}if(s<=a){(f>14e3||p>26697)&&u-a>100&&(s<a&&(c[f]=a-s,f+=2,s=a),o=D(a===u-1||s===u?1:0,c,f,g,e,h,a-h,t,o),f=p=g=0,h=a);var _=0;if(a<u-2&&(_=P(e,a,d,v,Math.min(i[2],u-a),i[3])),0!==_){var S,x=65535&_,O=B(S=_>>>16,m.of0);m.lhst[257+O]++;var w=B(x,m.df0);m.dhst[w]++,g+=m.exb[O]+m.dxb[w],c[f]=S<<23|a-s,c[f+1]=x<<16|O<<8|w,f+=2,s=a+S}else m.lhst[e[a]]++;p++}}for(h===a&&0!==e.length||(s<a&&(c[f]=a-s,f+=2,s=a),o=D(1,c,f,g,e,h,a-h,t,o),f=0,p=0,f=p=g=0,h=a);0!=(7&o);)o++;return o>>>3}function P(e,t,r,n,i,a){var o=32767&t,s=r[o],u=o-s+32768&32767;if(s===o||n!==A(e,t-u))return 0;for(var c=0,l=0,d=Math.min(32767,t);u<=d&&0!=--a&&s!==o;){if(0===c||e[t+c]===e[t+c-u]){var f=E(e,t,u);if(f>c){if(l=u,(c=f)>=i)break;u+2<f&&(f=u+2);for(var p=0,m=0;m<f-2;m++){var h=t-u+m+32768&32767,g=h-r[h]+32768&32767;g>p&&(p=g,s=h)}}}u+=(o=s)-(s=r[o])+32768&32767}return c<<16|l}function E(e,t,r){if(e[t]!==e[t-r]||e[t+1]!==e[t+1-r]||e[t+2]!==e[t+2-r])return 0;var n=t,i=Math.min(e.length,t+258);for(t+=3;t<i&&e[t]===e[t-r];)t++;return t-n}function A(e,t){return(e[t]<<8|e[t+1])+(e[t+2]<<4)&65535}function D(e,t,r,n,i,a,o,s,u){m.lhst[256]++;var c=function(){for(var e=C(m.lhst,m.ltree,15),t=C(m.dhst,m.dtree,15),r=[],n=k(m.ltree,r),i=[],a=k(m.dtree,i),o=0;o<r.length;o+=2)m.ihst[r[o]]++;for(o=0;o<i.length;o+=2)m.ihst[i[o]]++;var s=C(m.ihst,m.itree,7),u=19;for(;u>4&&0===m.itree[1+(m.ordr[u-1]<<1)];)u--;return[e,t,s,n,a,u,r,i]}(),l=c[0],d=c[1],f=c[2],p=c[3],h=c[4],b=c[5],y=c[6],_=c[7],S=32+(0==(u+3&7)?0:8-(u+3&7))+(o<<3),x=n+I(m.fltree,m.lhst)+I(m.fdtree,m.dhst),O=n+I(m.ltree,m.lhst)+I(m.dtree,m.dhst);O+=14+3*b+I(m.itree,m.ihst)+(2*m.ihst[16]+3*m.ihst[17]+7*m.ihst[18]);for(var w=0;w<286;w++)m.lhst[w]=0;for(w=0;w<30;w++)m.dhst[w]=0;for(w=0;w<19;w++)m.ihst[w]=0;var j=S<x&&S<O?0:x<O?1:2;if(L(s,u,e),L(s,u+1,j),u+=3,0===j){for(;0!=(7&u);)u++;u=T(i,a,o,s,u)}else{var P=void 0,E=void 0;if(1===j)P=m.fltree,E=m.fdtree;else{if(2!==j)throw new Error("unknown BTYPE "+j);g(m.ltree,l),v(m.ltree,l),g(m.dtree,d),v(m.dtree,d),g(m.itree,f),v(m.itree,f),P=m.ltree,E=m.dtree,R(s,u,p-257),R(s,u+=5,h-1),R(s,u+=5,b-4),u+=4;for(var A=0;A<b;A++)R(s,u+3*A,m.itree[1+(m.ordr[A]<<1)]);u+=3*b,u=M(y,m.itree,s,u),u=M(_,m.itree,s,u)}for(var D=a,B=0;B<r;B+=2){for(var N=t[B],F=N>>>23,U=D+(8388607&N);D<U;)u=V(i[D++],P,s,u);if(0!==F){var z=t[B+1],H=z>>16,G=z>>8&255,q=255&z;R(s,u=V(257+G,P,s,u),F-m.of0[G]),L(s,u=V(q,E,s,u+=m.exb[G]),H-m.df0[q]),u+=m.dxb[q],D+=F}}u=V(256,P,s,u)}return u}function T(e,t,r,n,i){var a=i>>>3;return n[a]=r,n[a+1]=r>>>8,n[a+2]=255-n[a],n[a+3]=255-n[a+1],a+=4,n.set(new Uint8Array(e.buffer,t,r),a),i+(r+4<<3)}function I(e,t){for(var r=0,n=0;n<t.length;n++)r+=t[n]*e[1+(n<<1)];return r}function M(e,t,r,n){for(var i=0;i<e.length;i+=2){var a=e[i],o=e[i+1];n=V(a,t,r,n);var s=16===a?2:17===a?3:7;a>15&&(R(r,n,o),n+=s)}return n}function k(e,t){for(var r=e.length;2!==r&&0===e[r-1];)r-=2;for(var n=0;n<r;n+=2){var i=e[n+1],a=n+3<r?e[n+3]:-1,o=n+5<r?e[n+5]:-1,s=0===n?-1:e[n-1];if(0===i&&a===i&&o===i){for(var u=n+5;u+2<r&&e[u+2]===i;)u+=2;(c=Math.min(u+1-n>>>1,138))<11?t.push(17,c-3):t.push(18,c-11),n+=2*c-2}else if(i===s&&a===i&&o===i){for(u=n+5;u+2<r&&e[u+2]===i;)u+=2;var c=Math.min(u+1-n>>>1,6);t.push(16,c-3),n+=2*c-2}else t.push(i,0)}return r>>>1}function B(e,t){var r=0;return 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Object(n.__generator)(this,(function(n){switch(n.label){case 0:return r+=4,r+=2,l=i(t,r+=2),r+=2,r+=4,r+=4,d=i(t,r+=8),f=i(t,r+=2),p=u(t,r+=2,d),r+=d,r+=f,c?(a[p]={size:s,csize:o},[2]):(m=new Uint8Array(t.buffer,r),0!==l?[3,1]:(a[p]=new Uint8Array(m.buffer.slice(r,r+o)),[3,4]));case 1:return 8!==l?[3,3]:(h=new Uint8Array(s),[4,U(e,m,h)]);case 2:return n.sent(),a[p]=h,[3,4];case 3:throw"unknown compression method: "+l;case 4:return[2]}}))}))}function U(e,t,r){return Object(n.__awaiter)(this,void 0,void 0,(function(){return Object(n.__generator)(this,(function(n){return[2,b(e,t,r)]}))}))}function z(e,t,r){return Object(n.__awaiter)(this,void 0,void 0,(function(){var a,s,u,c,l,f,p,m,h;return Object(n.__generator)(this,(function(n){switch(n.label){case 0:if(a=t[3],s=10,4&a&&(u=i(t,s),s+=u),8&a){for(c=s;0!==t[c];)++c;s=c+1}if(16&a){for(c=s;0!==t[c];)++c;s=c+1}return 1&a&&(s+=2),g=o(t,t.length-8),l=g>>0,f=o(t,t.length-4),void 0===r&&(r=new Uint8Array(f)),p=new 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s(e,t,0===i?67324752:33639248),t+=4,1===i&&(t+=2),a(e,t,20),a(e,t+=2,0),a(e,t+=2,n.cpr?8:0),s(e,t+=2,0),s(e,t+=4,n.crc),s(e,t+=4,u.length),s(e,t+=4,n.usize),a(e,t+=4,c(r)),a(e,t+=2,0),t+=2,1===i&&(t+=2,t+=2,s(e,t+=6,o),t+=4),t+=function(e,t,r){for(var n=r.length,i=0,a=0;a<n;a++){var o=r.charCodeAt(a);if(0==(4294967168&o))e[t+i]=o,i++;else if(0==(4294965248&o))e[t+i]=192|o>>6,e[t+i+1]=128|o>>0&63,i+=2;else if(0==(4294901760&o))e[t+i]=224|o>>12,e[t+i+1]=128|o>>6&63,e[t+i+2]=128|o>>0&63,i+=3;else{if(0!=(4292870144&o))throw"e";e[t+i]=240|o>>18,e[t+i+1]=128|o>>12&63,e[t+i+2]=128|o>>6&63,e[t+i+3]=128|o>>0&63,i+=4}}return i}(e,t,r),0===i&&(e.set(u,t),t+=u.length),t}!function(){for(var e=0;e<32768;e++){var t=e;t=(4278255360&(t=(4042322160&(t=(3435973836&(t=(2863311530&t)>>>1|(1431655765&t)<<1))>>>2|(858993459&t)<<2))>>>4|(252645135&t)<<4))>>>8|(16711935&t)<<8,m.rev15[e]=(t>>>16|t<<16)>>>17}function r(e,t,r){for(;0!=t--;)e.push(0,r)}for(e=0;e<32;e++)m.ldef[e]=m.of0[e]<<3|m.exb[e],m.ddef[e]=m.df0[e]<<4|m.dxb[e];r(m.fltree,144,8),r(m.fltree,112,9),r(m.fltree,24,7),r(m.fltree,8,8),g(m.fltree,9),h(m.fltree,9,m.flmap),v(m.fltree,9),r(m.fdtree,32,5),g(m.fdtree,5),h(m.fdtree,5,m.fdmap),v(m.fdtree,5),r(m.itree,19,0),r(m.ltree,286,0),r(m.dtree,30,0),r(m.ttree,320,0)}()},function(e,t,r){"use strict";r.d(t,"b",(function(){return a})),r.d(t,"a",(function(){return o}));var n=r(20),i=function(e){function t(t,r){var n=e.call(this,t,r)||this;return n.scheduler=t,n.work=r,n}return n.a(t,e),t.prototype.schedule=function(t,r){return void 0===r&&(r=0),r>0?e.prototype.schedule.call(this,t,r):(this.delay=r,this.state=t,this.scheduler.flush(this),this)},t.prototype.execute=function(t,r){return r>0||this.closed?e.prototype.execute.call(this,t,r):this._execute(t,r)},t.prototype.requestAsyncId=function(t,r,n){return void 0===n&&(n=0),null!==n&&n>0||null===n&&this.delay>0?e.prototype.requestAsyncId.call(this,t,r,n):t.flush(this)},t}(r(240).a),a=new(function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return n.a(t,e),t}(r(236).a))(i),o=a},function(e,t,r){"use strict";r.r(t),r.d(t,"StructureFocusRepresentationTags",(function(){return n})),r.d(t,"StructureFocusRepresentation",(function(){return y}));var n,i=r(0),a=r(342),o=r(338),s=r(4),u=r(167),c=r(31),l=r(177),d=r(10),f=r(13),p=r(135),m=r(2),h=r(27),g=["target","surroundings","interactions"];!function(e){e.TargetSel="structure-focus-target-sel",e.TargetRepr="structure-focus-target-repr",e.SurrSel="structure-focus-surr-sel",e.SurrRepr="structure-focus-surr-repr",e.SurrNciRepr="structure-focus-surr-nci-repr"}(n||(n={}));var v=new Set([n.TargetSel,n.TargetRepr,n.SurrSel,n.SurrRepr,n.SurrNciRepr]),b=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.currentSource=void 0,t}return Object(i.__extends)(t,e),Object.defineProperty(t.prototype,"surrLabel",{get:function(){return"[Focus] Surroundings ("+this.params.expandRadius+" Å)"},enumerable:!1,configurable:!0}),t.prototype.getReprParams=function(e){return Object(i.__assign)(Object(i.__assign)({},this.params.targetParams),{type:{name:e.type.name,params:Object(i.__assign)(Object(i.__assign)({},e.type.params),{ignoreHydrogens:this.params.ignoreHydrogens})}})},t.prototype.ensureShape=function(e){var t=this.plugin.state.data,r=t.tree,i=t.build(),a=f.StateSelection.findUniqueTagsInSubtree(r,e.transform.ref,v);a[n.TargetSel]||(a[n.TargetSel]=i.to(e).apply(c.StateTransforms.Model.StructureSelectionFromBundle,{bundle:s.StructureElement.Bundle.Empty,label:"[Focus] Target"},{tags:n.TargetSel}).ref),a[n.SurrSel]||(a[n.SurrSel]=i.to(e).apply(c.StateTransforms.Model.StructureSelectionFromExpression,{expression:d.MolScriptBuilder.struct.generator.empty(),label:this.surrLabel},{tags:n.SurrSel}).ref);var o=this.params.components;return o.indexOf("target")>=0&&!a[n.TargetRepr]&&(a[n.TargetRepr]=i.to(a[n.TargetSel]).apply(c.StateTransforms.Representation.StructureRepresentation3D,this.getReprParams(this.params.targetParams),{tags:n.TargetRepr}).ref),o.indexOf("surroundings")>=0&&!a[n.SurrRepr]&&(a[n.SurrRepr]=i.to(a[n.SurrSel]).apply(c.StateTransforms.Representation.StructureRepresentation3D,this.getReprParams(this.params.surroundingsParams),{tags:n.SurrRepr}).ref),o.indexOf("interactions")>=0&&!a[n.SurrNciRepr]&&(a[n.SurrNciRepr]=i.to(a[n.SurrSel]).apply(c.StateTransforms.Representation.StructureRepresentation3D,this.params.nciParams,{tags:n.SurrNciRepr}).ref),{state:t,builder:i,refs:a}},t.prototype.clear=function(e){var t=this.plugin.state.data;this.currentSource=void 0;var r=t.select(f.StateSelection.Generators.byRef(e).subtree().withTag(n.TargetSel)),a=t.select(f.StateSelection.Generators.byRef(e).subtree().withTag(n.SurrSel));if(0!==r.length||0!==a.length){for(var o=t.build(),u=s.StructureElement.Bundle.Empty,l=0,p=r;l<p.length;l++){var m=p[l];o.to(m).update(c.StateTransforms.Model.StructureSelectionFromBundle,(function(e){return Object(i.__assign)(Object(i.__assign)({},e),{bundle:u})}))}for(var g=d.MolScriptBuilder.struct.generator.empty(),v=0,b=a;v<b.length;v++){var y=b[v];o.to(y).update(c.StateTransforms.Model.StructureSelectionFromExpression,(function(e){return Object(i.__assign)(Object(i.__assign)({},e),{expression:g})}))}return h.PluginCommands.State.Update(this.plugin,{state:t,tree:o,options:{doNotLogTiming:!0,doNotUpdateCurrent:!0}})}},t.prototype.focus=function(e){return Object(i.__awaiter)(this,void 0,void 0,(function(){var t,r,a,o,u,l,f,p,m,g,v=this;return Object(i.__generator)(this,(function(b){switch(b.label){case 0:return(t=this.plugin.helpers.substructureParent.get(e.structure))&&t.obj?(this.currentSource=e,r=s.StructureElement.Loci.remap(e,t.obj.data),a=s.StructureElement.Loci.extendToWholeResidues(r),o=s.StructureElement.Bundle.fromLoci(a),u=s.StructureElement.Bundle.toExpression(o),l=d.MolScriptBuilder.struct.modifier.includeSurroundings({0:u,radius:this.params.expandRadius,"as-whole-residues":!0}),this.params.excludeTargetFromSurroundings&&(l=d.MolScriptBuilder.struct.modifier.exceptBy({0:l,by:u})),f=this.ensureShape(t),p=f.state,m=f.builder,g=f.refs,m.to(g[n.TargetSel]).update(c.StateTransforms.Model.StructureSelectionFromBundle,(function(e){return Object(i.__assign)(Object(i.__assign)({},e),{bundle:o})})),m.to(g[n.SurrSel]).update(c.StateTransforms.Model.StructureSelectionFromExpression,(function(e){return Object(i.__assign)(Object(i.__assign)({},e),{expression:l,label:v.surrLabel})})),[4,h.PluginCommands.State.Update(this.plugin,{state:p,tree:m,options:{doNotLogTiming:!0,doNotUpdateCurrent:!0}})]):[2];case 1:return b.sent(),[2]}}))}))},t.prototype.register=function(e){var t=this;this.subscribeObservable(this.plugin.managers.structure.focus.behaviors.current,(function(e){e?t.focus(e.loci):t.clear(f.StateTransform.RootRef)}))},t.prototype.update=function(e){return Object(i.__awaiter)(this,void 0,void 0,(function(){var t,r,a,o,s,u,c,l,d,p,m,g,v;return Object(i.__generator)(this,(function(i){switch(i.label){case 0:if(t=this.params,this.params=e,t.excludeTargetFromSurroundings!==e.excludeTargetFromSurroundings)return this.currentSource&&this.focus(this.currentSource),[2,!0];for(r=this.plugin.state.data,a=r.build(),o=f.StateSelection.Generators.root.subtree(),s=this.params.components,u=s.indexOf("target")>=0,c=0,l=r.select(o.withTag(n.TargetRepr));c<l.length;c++)v=l[c],u?a.to(v).update(this.getReprParams(this.params.targetParams)):a.delete(v.transform.ref);for(u=s.indexOf("surroundings")>=0,d=0,p=r.select(o.withTag(n.SurrRepr));d<p.length;d++)v=p[d],u?a.to(v).update(this.getReprParams(this.params.surroundingsParams)):a.delete(v.transform.ref);for(u=s.indexOf("interactions")>=0,m=0,g=r.select(o.withTag(n.SurrNciRepr));m<g.length;m++)v=g[m],u?a.to(v).update(this.params.nciParams):a.delete(v.transform.ref);return[4,h.PluginCommands.State.Update(this.plugin,{state:r,tree:a,options:{doNotLogTiming:!0,doNotUpdateCurrent:!0}})];case 1:return i.sent(),e.expandRadius!==t.expandRadius?(this.currentSource&&this.focus(this.currentSource),[2,!0]):[2,!0]}}))}))},t}(l.PluginBehavior.WithSubscribers),y=l.PluginBehavior.create({name:"create-structure-focus-representation",display:{name:"Structure Focus Representation"},category:"interaction",ctor:b,params:function(e,t){return function(e){var t=c.StateTransforms.Representation.StructureRepresentation3D.definition.params(void 0,e);return{expandRadius:m.ParamDefinition.Numeric(5,{min:1,max:10,step:1}),targetParams:m.ParamDefinition.Group(t,{label:"Target",customDefault:Object(u.createStructureRepresentationParams)(e,void 0,{type:"ball-and-stick",size:"physical",typeParams:{sizeFactor:.26,alpha:.51}})}),surroundingsParams:m.ParamDefinition.Group(t,{label:"Surroundings",customDefault:Object(u.createStructureRepresentationParams)(e,void 0,{type:"ball-and-stick",size:"physical",typeParams:{sizeFactor:.16}})}),nciParams:m.ParamDefinition.Group(t,{label:"Non-covalent 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t=e.plugin,r=e.cropFrameColor,a=t.helpers.viewportScreenshot,o=Object(i.useState)(null),s=o[0],u=o[1],c=Object(i.useRef)(null),l=Object(i.useRef)(e);return Object(i.useEffect)((function(){l.current=e}),Object.values(e)),Object(i.useEffect)((function(){s!==c.current&&u(c.current)})),Object(i.useEffect)((function(){var e,r=!1,n=[];function i(e,t){e&&n.push(e.subscribe(t))}function o(){var e=l.current;!e.suspend&&c.current&&g(a,c.current,e.customBackground,e.borderColor,e.borderWidth),c.current||(r=!0)}var s=setInterval((function(){r&&(r=!1,o())}),125);i(t.events.canvas3d.settingsUpdated,(function(){return r=!0})),i(null===(e=t.canvas3d)||void 0===e?void 0:e.didDraw,(function(){return r=!0})),i(t.state.data.behaviors.isUpdating,(function(e){e||(r=!0)})),i(a.behaviors.values,(function(){return r=!0})),i(a.behaviors.cropParams,(function(){return r=!0}));var u=void 0;"undefined"!=typeof ResizeObserver&&(u=new ResizeObserver((function(){return r=!0})));var d=c.current;return 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i.createElement("div",null,this.state.showPreview&&i.createElement("div",{className:"msp-image-preview"},i.createElement(h,{plugin:this.plugin}),i.createElement(O,{plugin:this.plugin})),i.createElement("div",{className:"msp-flex-row"},r&&i.createElement(u.Button,{icon:c.CopySvg,onClick:this.copy,disabled:this.state.isDisabled},"Copy"),!r&&!this.state.imageData&&i.createElement(u.Button,{icon:c.CopySvg,onClick:this.copyImg,disabled:this.state.isDisabled},"Copy"),this.state.imageData&&i.createElement(u.Button,{onClick:function(){return t.setState({imageData:void 0})},disabled:this.state.isDisabled},"Clear"),i.createElement(u.Button,{icon:c.GetAppSvg,onClick:this.download,disabled:this.state.isDisabled},"Download")),this.state.imageData&&i.createElement("div",{className:"msp-row msp-copy-image-wrapper"},i.createElement("div",null,"Right click below + Copy 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t.allCollapsedState={isSettingsExpanded:!1,isScreenshotExpanded:!1},t.state=Object(n.__assign)({},t.allCollapsedState),t.resetCamera=function(){a.PluginCommands.Camera.Reset(t.plugin,{})},t.toggleSettingsExpanded=t.toggle("isSettingsExpanded"),t.toggleScreenshotExpanded=t.toggle("isScreenshotExpanded"),t.toggleControls=function(){a.PluginCommands.Layout.Update(t.plugin,{state:{showControls:!t.plugin.layout.state.showControls}})},t.toggleExpanded=function(){a.PluginCommands.Layout.Update(t.plugin,{state:{isExpanded:!t.plugin.layout.state.isExpanded}})},t.setSettings=function(e){var r;a.PluginCommands.Canvas3D.SetSettings(t.plugin,{settings:(r={},r[e.name]=e.value,r)})},t.setLayout=function(e){var r;a.PluginCommands.Layout.Update(t.plugin,{state:(r={},r[e.name]=e.value,r)})},t.screenshot=function(){var e;null===(e=t.plugin.helpers.viewportScreenshot)||void 0===e||e.download()},t.onMouseMove=function(e){0===e.buttons&&e.stopPropagation()},t}return Object(n.__extends)(t,e),t.prototype.toggle=function(e){var t=this;return function(r){var i;t.setState(Object(n.__assign)(Object(n.__assign)({},t.allCollapsedState),((i={})[e]=!t.state[e],i))),null==r||r.currentTarget.blur()}},t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.events.canvas3d.settingsUpdated,(function(){return e.forceUpdate()})),this.subscribe(this.plugin.layout.events.updated,(function(){return e.forceUpdate()}))},t.prototype.icon=function(e,t,r,n){return void 0===n&&(n=!0),i.createElement(u.IconButton,{svg:e,toggleState:n,onClick:t,title:r,style:{background:"transparent"}})},t.prototype.render=function(){return i.createElement("div",{className:"msp-viewport-controls",onMouseMove:this.onMouseMove},i.createElement("div",{className:"msp-viewport-controls-buttons"},i.createElement("div",null,i.createElement("div",{className:"msp-semi-transparent-background"}),this.icon(c.AutorenewSvg,this.resetCamera,"Reset 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close.",initialExpanded:!0,hideExpander:!0,hideOffset:!0,onHeaderClick:this.toggleSettingsExpanded,topRightIcon:c.CloseSvg,noTopMargin:!0,childrenClassName:"msp-viewport-controls-panel-controls"},i.createElement(w.SimpleSettingsControl,null))))},t}(s.PluginUIComponent),j=function(){return i.createElement("a",{className:"msp-logo",href:"https://molstar.org",target:"_blank"})},P=function(){return i.createElement(d,{logo:j})}},function(e,t,r){"use strict";r.r(t),r.d(t,"StructureComponentControls",(function(){return y})),r.d(t,"AddComponentControls",(function(){return S}));var n=r(0),i=r(3),a=r(167),o=r(260),s=r(284),u=r(27),c=r(13),l=r(2),d=r(33),f=r(56),p=r(18),m=r(15),h=r(73),g=r(189),v=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return Object(n.__extends)(t,e),Object.defineProperty(t.prototype,"current",{get:function(){return this.plugin.managers.structure.hierarchy.behaviors.selection},enumerable:!1,configurable:!0}),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.current,(function(){return e.forceUpdate()}))},Object.defineProperty(t.prototype,"unitcell",{get:function(){var e,t=this.plugin.managers.structure.hierarchy.selection;if(0===t.structures.length)return null;for(var r=[],n=0,a=t.structures;n<a.length;n++){var o=a[n].model;(null==o?void 0:o.unitcell)&&(null===(e=o.unitcell)||void 0===e?void 0:e.cell.obj)&&r.push(o.unitcell)}return 0===r.length?null:i.createElement(b,{refs:r,labelMultiple:"Unit Cells"})},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"customControls",{get:function(){var e=this,t=[];return this.plugin.genericRepresentationControls.forEach((function(r,n){var a=r(e.plugin.managers.structure.hierarchy.selection),o=a[0],s=a[1];o.length>0&&t.push(i.createElement("div",{key:n},i.createElement(b,{refs:o,labelMultiple:s})))})),t.length>0?t:null},enumerable:!1,configurable:!0}),t.prototype.render=function(){return i.createElement(i.Fragment,null,i.createElement("div",{style:{marginTop:"6px"}},this.unitcell,this.customControls))},t}(d.PurePluginUIComponent),b=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={showOptions:!1},t.toggleVisibility=function(e){e.preventDefault(),t.plugin.managers.structure.hierarchy.toggleVisibility(t.props.refs),e.currentTarget.blur()},t.highlight=function(e){e.preventDefault(),t.pivot.cell.parent&&u.PluginCommands.Interactivity.Object.Highlight(t.plugin,{state:t.pivot.cell.parent,ref:t.props.refs.map((function(e){return e.cell.transform.ref}))})},t.clearHighlight=function(e){e.preventDefault(),u.PluginCommands.Interactivity.ClearHighlights(t.plugin)},t.focus=function(e){var r;e.preventDefault();for(var n=!0,i=0,a=t.props.refs;i<a.length;i++){if(!(c=a[i]).cell.state.isHidden){n=!1;break}}n&&t.plugin.managers.structure.hierarchy.toggleVisibility(t.props.refs,"show");for(var o=[],s=0,u=t.props.refs;s<u.length;s++){var c;if(!(c=u[s]).cell.state.isHidden){var l=null===(r=c.cell.obj)||void 0===r?void 0:r.data.repr.getLoci();l&&o.push(l)}}t.plugin.managers.camera.focusLoci(o)},t.toggleOptions=function(){return t.setState({showOptions:!t.state.showOptions})},t}return Object(n.__extends)(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.state.events.cell.stateUpdated,(function(t){var r;c.State.ObjectEvent.isCell(t,null===(r=e.pivot)||void 0===r?void 0:r.cell)&&e.forceUpdate()}))},Object.defineProperty(t.prototype,"pivot",{get:function(){return this.props.refs[0]},enumerable:!1,configurable:!0}),t.prototype.render=function(){var e=this.props,t=e.refs,r=e.labelMultiple;if(0===t.length)return null;var n,a,o=t[0];if(1===t.length){var s=o.cell.obj;if(!s)return null;n=null==s?void 0:s.label,a=null==s?void 0:s.description}else n=t.length+" "+(r||"Objects");return i.createElement(i.Fragment,null,i.createElement("div",{className:"msp-flex-row"},i.createElement("button",{className:"msp-form-control msp-control-button-label",title:n+". Click to focus.",onClick:this.focus,onMouseEnter:this.highlight,onMouseLeave:this.clearHighlight,style:{textAlign:"left"}},n," ",i.createElement("small",null,a)),i.createElement(p.IconButton,{svg:o.cell.state.isHidden?m.VisibilityOffOutlinedSvg:m.VisibilityOutlinedSvg,toggleState:!1,className:"msp-form-control",onClick:this.toggleVisibility,title:o.cell.state.isHidden?"Show":"Hide",small:!0,flex:!0}),1===t.length&&i.createElement(p.IconButton,{svg:m.MoreHorizSvg,className:"msp-form-control",onClick:this.toggleOptions,title:"Options",toggleState:this.state.showOptions,flex:!0})),1===t.length&&this.state.showOptions&&o.cell.parent&&i.createElement(i.Fragment,null,i.createElement("div",{className:"msp-control-offset"},i.createElement(g.UpdateTransformControl,{state:o.cell.parent,transform:o.cell.transform,customHeader:"none",autoHideApply:!0}))))},t}(d.PurePluginUIComponent),y=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return Object(n.__extends)(t,e),t.prototype.defaultState=function(){return{header:"Components",isCollapsed:!1,isDisabled:!1,brand:{accent:"blue",svg:m.CubeOutlineSvg}}},t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.managers.structure.hierarchy.behaviors.selection,(function(t){return e.setState({description:s.StructureHierarchyManager.getSelectedStructuresDescription(e.plugin)})}))},t.prototype.renderControls=function(){return i.createElement(i.Fragment,null,i.createElement(_,null),i.createElement(O,null),i.createElement(v,null))},t}(d.CollapsableControls),_=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={isEmpty:!0,isBusy:!1,canUndo:!1},t.togglePreset=t.toggleAction("preset"),t.toggleAdd=t.toggleAction("add"),t.toggleOptions=t.toggleAction("options"),t.hideAction=function(){return t.setState({action:void 0})},t.applyPreset=function(e){if(t.hideAction(),e){var r=t.plugin.managers.structure,n=r.hierarchy.selection.structures;null===e.value?r.component.clear(n):r.component.applyPreset(n,e.value)}},t.undo=function(){var e=t.plugin.state.data.undo();e&&t.plugin.runTask(e)},t}return Object(n.__extends)(t,e),Object.defineProperty(t.prototype,"isDisabled",{get:function(){return this.state.isBusy||this.state.isEmpty},enumerable:!1,configurable:!0}),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.managers.structure.hierarchy.behaviors.selection,(function(t){return e.setState({action:"options"!==e.state.action||0===t.structures.length?void 0:"options",isEmpty:0===t.structures.length})})),this.subscribe(this.plugin.behaviors.state.isBusy,(function(t){e.setState({isBusy:t,action:"options"!==e.state.action?void 0:"options"})})),this.subscribe(this.plugin.state.data.events.historyUpdated,(function(t){var r=t.state;e.setState({canUndo:r.canUndo})}))},t.prototype.toggleAction=function(e){var t=this;return function(){return t.setState({action:t.state.action===e?void 0:e})}},Object.defineProperty(t.prototype,"presetControls",{get:function(){return i.createElement(f.a,{items:this.presetActions,onSelect:this.applyPreset})},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"presetActions",{get:function(){var e=this.plugin.managers.structure.component.pivotStructure,t=this.plugin.builders.structure.representation.getPresets(null==e?void 0:e.cell.obj);return f.a.createItems(t,{label:function(e){return e.display.name},category:function(e){return e.display.group},description:function(e){return e.display.description}})},enumerable:!1,configurable:!0}),t.prototype.render=function(){var e=this.state.canUndo?"Undo "+this.plugin.state.data.latestUndoLabel:"Some mistakes of the past can be undone.";return i.createElement(i.Fragment,null,i.createElement("div",{className:"msp-flex-row"},i.createElement(p.ToggleButton,{icon:m.BookmarksOutlinedSvg,label:"Preset",title:"Apply a representation preset for the current structure(s).",toggle:this.togglePreset,isSelected:"preset"===this.state.action,disabled:this.isDisabled}),i.createElement(p.ToggleButton,{icon:m.AddSvg,label:"Add",title:"Add a new representation component for a selection.",toggle:this.toggleAdd,isSelected:"add"===this.state.action,disabled:this.isDisabled}),i.createElement(p.ToggleButton,{icon:m.TuneSvg,label:"",title:"Options that are applied to all applicable representations.",style:{flex:"0 0 40px",padding:0},toggle:this.toggleOptions,isSelected:"options"===this.state.action,disabled:this.isDisabled}),i.createElement(p.IconButton,{svg:m.RestoreSvg,className:"msp-flex-item",flex:"40px",onClick:this.undo,disabled:!this.state.canUndo||this.isDisabled,title:e})),"preset"===this.state.action&&this.presetControls,"add"===this.state.action&&i.createElement("div",{className:"msp-control-offset"},i.createElement(S,{onApply:this.hideAction})),"options"===this.state.action&&i.createElement("div",{className:"msp-control-offset"},i.createElement(x,{isDisabled:this.isDisabled})))},t}(d.PurePluginUIComponent),S=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state=t.createState(),t.apply=function(){var e=t.props.forSelection?t.currentStructures:t.selectedStructures;t.props.onApply(),t.plugin.managers.structure.component.add(t.state.values,e)},t.paramsChanged=function(e){return t.setState({values:e})},t}return Object(n.__extends)(t,e),t.prototype.createState=function(){var e=o.StructureComponentManager.getAddParams(this.plugin);return{params:e,values:l.ParamDefinition.getDefaultValues(e)}},Object.defineProperty(t.prototype,"selectedStructures",{get:function(){return this.plugin.managers.structure.component.currentStructures},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"currentStructures",{get:function(){return this.plugin.managers.structure.hierarchy.current.structures},enumerable:!1,configurable:!0}),t.prototype.render=function(){return i.createElement(i.Fragment,null,i.createElement(h.ParameterControls,{params:this.state.params,values:this.state.values,onChangeValues:this.paramsChanged}),i.createElement(p.Button,{icon:m.AddSvg,title:"Use Selection and optional Representation to create a new Component.",className:"msp-btn-commit msp-btn-commit-on",onClick:this.apply,style:{marginTop:"1px"}},"Create Component"))},t}(d.PurePluginUIComponent),x=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.update=function(e){return t.plugin.managers.structure.component.setOptions(e)},t}return Object(n.__extends)(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.managers.structure.component.events.optionsUpdated,(function(){return e.forceUpdate()}))},t.prototype.render=function(){return i.createElement(h.ParameterControls,{params:o.StructureComponentManager.OptionsParams,values:this.plugin.managers.structure.component.state.options,onChangeValues:this.update,isDisabled:this.props.isDisabled})},t}(d.PurePluginUIComponent),O=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return Object(n.__extends)(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.managers.structure.hierarchy.behaviors.selection,(function(){e.forceUpdate()}))},t.prototype.render=function(){var e=this.plugin.managers.structure.hierarchy.currentComponentGroups;return 0===e.length?null:i.createElement("div",{style:{marginTop:"6px"}},e.map((function(e){return i.createElement(w,{key:e[0].cell.transform.ref,group:e})})))},t}(d.PurePluginUIComponent),w=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={action:void 0},t.toggleVisible=function(e){e.preventDefault(),e.currentTarget.blur(),t.plugin.managers.structure.component.toggleVisibility(t.props.group)},t.selectAction=function(e){e&&(t.setState({action:void 0}),(null==e?void 0:e.value)())},t.remove=function(){return t.plugin.managers.structure.hierarchy.remove(t.props.group,!0)},t.toggleAction=function(){return t.setState({action:"action"===t.state.action?void 0:"action"})},t.toggleLabel=function(){return t.setState({action:"label"===t.state.action?void 0:"label"})},t.highlight=function(e){e.preventDefault(),t.props.group[0].cell.parent&&u.PluginCommands.Interactivity.Object.Highlight(t.plugin,{state:t.props.group[0].cell.parent,ref:t.props.group.map((function(e){return e.cell.transform.ref}))})},t.clearHighlight=function(e){e.preventDefault(),u.PluginCommands.Interactivity.ClearHighlights(t.plugin)},t.focus=function(){for(var e=!0,r=0,n=t.props.group;r<n.length;r++){if(!n[r].cell.state.isHidden){e=!1;break}}e&&t.plugin.managers.structure.hierarchy.toggleVisibility(t.props.group,"show"),t.plugin.managers.camera.focusSpheres(t.props.group,(function(e){var t;if(!e.cell.state.isHidden)return null===(t=e.cell.obj)||void 0===t?void 0:t.data.boundary.sphere}))},t.updateLabel=function(e){t.plugin.managers.structure.component.updateLabel(t.pivot,e)},t}return Object(n.__extends)(t,e),Object.defineProperty(t.prototype,"pivot",{get:function(){return this.props.group[0]},enumerable:!1,configurable:!0}),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.state.events.cell.stateUpdated,(function(t){c.State.ObjectEvent.isCell(t,e.pivot.cell)&&e.forceUpdate()}))},Object.defineProperty(t.prototype,"colorByActions",{get:function(){var e,t,r=this,n=this.plugin.managers.structure.component,i=null===(e=this.pivot.representations[0].cell.transform.params)||void 0===e?void 0:e.colorTheme.name,o=Object(a.getStructureThemeTypes)(this.plugin,null===(t=this.pivot.cell.obj)||void 0===t?void 0:t.data);return f.a.createItemsFromSelectOptions(o,{value:function(e){return function(){return n.updateRepresentationsTheme(r.props.group,{color:e[0]})}},selected:function(e){return e[0]===i}})},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"actions",{get:function(){var e=this,t=this.plugin.managers.structure.component,r=[Object(n.__spreadArrays)([f.a.Header("Add Representation")],o.StructureComponentManager.getRepresentationTypes(this.plugin,this.props.group[0]).map((function(r){return f.a.Item(r[1],(function(){return t.addRepresentation(e.props.group,r[0])}))})))];return this.pivot.representations.length>0&&r.push(Object(n.__spreadArrays)([f.a.Header("Set Coloring",{isIndependent:!0})],this.colorByActions)),t.canBeModified(this.props.group[0])&&r.push([f.a.Header("Modify by Selection"),f.a.Item("Include",(function(){return t.modifyByCurrentSelection(e.props.group,"union")}),{icon:m.UnionSvg}),f.a.Item("Subtract",(function(){return t.modifyByCurrentSelection(e.props.group,"subtract")}),{icon:m.SubtractSvg}),f.a.Item("Intersect",(function(){return t.modifyByCurrentSelection(e.props.group,"intersect")}),{icon:m.IntersectSvg})]),r.push(f.a.Item("Select This",(function(){return t.selectThis(e.props.group)}),{icon:m.SetSvg})),t.canBeModified(this.props.group[0])&&r.push(f.a.Item("Edit Label",this.toggleLabel)),r},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"reprLabel",{get:function(){var e,t=this.pivot;return 0===t.representations.length?"No repr.":1===t.representations.length?null===(e=t.representations[0].cell.obj)||void 0===e?void 0:e.label:t.representations.length+" reprs"},enumerable:!1,configurable:!0}),t.prototype.render=function(){var e,t=this,r=this.pivot,n=r.cell,a=null===(e=n.obj)||void 0===e?void 0:e.label,o=this.reprLabel;return i.createElement(i.Fragment,null,i.createElement("div",{className:"msp-flex-row"},i.createElement(p.Button,{noOverflow:!0,className:"msp-control-button-label",title:a+". Click to focus.",onClick:this.focus,onMouseEnter:this.highlight,onMouseLeave:this.clearHighlight,style:{textAlign:"left"}},a,i.createElement("small",{className:"msp-25-lower-contrast-text",style:{float:"right"}},o)),i.createElement(p.IconButton,{svg:n.state.isHidden?m.VisibilityOffOutlinedSvg:m.VisibilityOutlinedSvg,toggleState:!1,onClick:this.toggleVisible,title:(n.state.isHidden?"Show":"Hide")+" component",small:!0,className:"msp-form-control",flex:!0}),i.createElement(p.IconButton,{svg:m.DeleteOutlinedSvg,toggleState:!1,onClick:this.remove,title:"Remove",small:!0,className:"msp-form-control",flex:!0}),i.createElement(p.IconButton,{svg:m.MoreHorizSvg,onClick:this.toggleAction,title:"Actions",toggleState:"action"===this.state.action,className:"msp-form-control",flex:!0})),"label"===this.state.action&&i.createElement("div",{className:"msp-control-offset",style:{marginBottom:"6px"}},i.createElement(p.ControlRow,{label:"Label",control:i.createElement("div",{style:{display:"flex",textAlignLast:"center"}},i.createElement(p.TextInput,{onChange:this.updateLabel,value:a,style:{flex:"1 1 auto",minWidth:0},className:"msp-form-control",blurOnEnter:!0,blurOnEscape:!0}),i.createElement(p.IconButton,{svg:m.CheckSvg,onClick:this.toggleLabel,className:"msp-form-control msp-control-button-label",flex:!0}))})),"action"===this.state.action&&i.createElement("div",{className:"msp-accent-offset"},i.createElement("div",{style:{marginBottom:"6px"}},i.createElement(f.a,{items:this.actions,onSelect:this.selectAction,noOffset:!0})),i.createElement("div",{style:{marginBottom:"6px"}},r.representations.map((function(e){return i.createElement(C,{group:t.props.group,key:e.cell.transform.ref,representation:e})})))))},t}(d.PurePluginUIComponent),C=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.remove=function(){return t.plugin.managers.structure.component.removeRepresentations(t.props.group,t.props.representation)},t.toggleVisible=function(e){e.preventDefault(),e.currentTarget.blur(),t.plugin.managers.structure.component.toggleVisibility(t.props.group,t.props.representation)},t.update=function(e){return t.plugin.managers.structure.component.updateRepresentations(t.props.group,t.props.representation,e)},t}return Object(n.__extends)(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.state.events.cell.stateUpdated,(function(t){c.State.ObjectEvent.isCell(t,e.props.representation.cell)&&e.forceUpdate()}))},t.prototype.render=function(){var e,t=this.props.representation.cell;return i.createElement("div",{className:"msp-representation-entry"},t.parent&&i.createElement(p.ExpandGroup,{header:((null===(e=t.obj)||void 0===e?void 0:e.label)||"")+" 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o=e.namedComputeRenderables["histogram-pyramid"].values;u.e.update(o.tInputLevel,t),u.e.update(o.tPreviousLevel,r),e.namedComputeRenderables["histogram-pyramid"].update()}else e.namedComputeRenderables["histogram-pyramid"]=function(e,t,r){var o=Object(n.__assign)(Object(n.__assign)({},c.c),{tInputLevel:u.e.create(t),tPreviousLevel:u.e.create(r),uSize:u.e.create(0),uTexSize:u.e.create(0),uFirst:u.e.create(!0)}),l=Object(n.__assign)({},b),f=Object(s.g)("reduction",d.a,"\nprecision highp float;\nprecision highp int;\nprecision highp sampler2D;\n\nuniform sampler2D tInputLevel;\n\n// previous level used to evaluate the new level\n#if __VERSION__ == 100\n    uniform sampler2D tPreviousLevel;\n#else\n    precision highp isampler2D;\n    uniform isampler2D tPreviousLevel;\n#endif\n\n// inverted size of the previous level texture.\nuniform float uSize;\nuniform float uTexSize;\nuniform bool uFirst;\n\n#include common\n\nvoid main(void) {\n    float k = 0.5 * uSize;\n    vec2 position = floor((gl_FragCoord.xy / uTexSize) / uSize) * uSize;\n\n    #if __VERSION__ == 100\n        float a, b, c, d;\n\n        if (uFirst) {\n            a = texture2D(tInputLevel, position).r * 255.0;\n            b = texture2D(tInputLevel, position + vec2(k, 0.0)).r * 255.0;\n            c = texture2D(tInputLevel, position + vec2(0.0, k)).r * 255.0;\n            d = texture2D(tInputLevel, position + vec2(k, k)).r * 255.0;\n        } else {\n            a = decodeFloatRGB(texture2D(tPreviousLevel, position).rgb);\n            b = decodeFloatRGB(texture2D(tPreviousLevel, position + vec2(k, 0.0)).rgb);\n            c = decodeFloatRGB(texture2D(tPreviousLevel, position + vec2(0.0, k)).rgb);\n            d = decodeFloatRGB(texture2D(tPreviousLevel, position + vec2(k, k)).rgb);\n        }\n        gl_FragColor = vec4(encodeFloatRGB(a + b + c + d), 1.0);\n    #else\n        int a, b, c, d;\n\n        if (uFirst) {\n            a = int(texture2D(tInputLevel, position).r * 255.0);\n            b = int(texture2D(tInputLevel, position + vec2(k, 0.0)).r * 255.0);\n            c = int(texture2D(tInputLevel, position + vec2(0.0, k)).r * 255.0);\n            d = int(texture2D(tInputLevel, position + vec2(k, k)).r * 255.0);\n        } else {\n            a = texture2D(tPreviousLevel, position).r;\n            b = texture2D(tPreviousLevel, position + vec2(k, 0.0)).r;\n            c = texture2D(tPreviousLevel, position + vec2(0.0, k)).r;\n            d = texture2D(tPreviousLevel, position + vec2(k, k)).r;\n        }\n        gl_FragColor = ivec4(a + b + c + d);\n    #endif\n}\n",{},{0:"ivec4"}),p=Object(a.a)(e,"triangles",f,l,o);return Object(i.a)(p,o)}(e,t,r);return e.namedComputeRenderables["histogram-pyramid"]}var _=[];function S(e,t){var r=_[t],n=Math.pow(2,t);if(void 0===r){var i=e.isWebGL2?O("level"+t,e,"image-int32","alpha","int","nearest"):O("level"+t,e,"image-uint8","rgba","ubyte","nearest");i.define(n,n);var a=x("level"+t,e);i.attachFramebuffer(a,0),r={texture:i,framebuffer:a},_[t]=r}return r}function x(e,t){var r="histogram-pyramid-"+e;return t.namedFramebuffers[r]||(t.namedFramebuffers[r]=t.resources.framebuffer()),t.namedFramebuffers[r]}function O(e,t,r,n,i,a){var o="histogram-pyramid-"+e;return t.namedTextures[o]||(t.namedTextures[o]=t.resources.texture(r,n,i,a)),t.namedTextures[o]}function w(e,t,r,n){var i=e.gl,a=t.getWidth();if(a!==t.getHeight()||!Object(v.e)(a))throw new Error("inputTexture must be of square power-of-two size");var o=Math.ceil(Math.log(a)/Math.log(2)),s=Math.pow(2,o),c=Math.pow(2,o),d=Math.pow(2,o-1),p=e.isWebGL2?O("pyramid",e,"image-int32","alpha","int","nearest"):O("pyramid",e,"image-uint8","rgba","ubyte","nearest");p.define(c,d);var b=x("pyramid",e);p.attachFramebuffer(b,0),i.viewport(0,0,c,d),Object(f.q)(i)?i.clearBufferiv(i.COLOR,0,[0,0,0,0]):i.clear(i.COLOR_BUFFER_BIT);for(var _=[],w=0;w<o;++w)_.push(S(e,w));var C=y(e,t,_[0].texture);e.state.currentRenderItemId=-1,function(e){var t=e.gl,r=e.state;r.disable(t.CULL_FACE),r.disable(t.BLEND),r.disable(t.DEPTH_TEST),r.enable(t.SCISSOR_TEST),r.depthMask(!1),r.colorMask(!0,!0,!0,!0),r.clearColor(0,0,0,0)}(e);var j=0;for(w=0;w<o;w++){var P=o-1-w;_[P].framebuffer.bind();var E=Math.pow(2,P);u.e.update(C.values.uSize,Math.pow(2,w+1)/s),u.e.update(C.values.uTexSize,E),u.e.updateIfChanged(C.values.uFirst,0===w),w>0&&(u.e.update(C.values.tPreviousLevel,_[o-w].texture),C.update()),e.state.currentRenderItemId=-1,i.viewport(0,0,E,E),i.scissor(0,0,E,E),Object(f.q)(i)?i.clearBufferiv(i.COLOR,0,[0,0,0,0]):i.clear(i.COLOR_BUFFER_BIT),i.scissor(0,0,n[0],n[1]),C.render(),p.bind(0),i.copyTexSubImage2D(i.TEXTURE_2D,0,j,0,0,0,E,E),p.unbind(0),j+=E}i.finish();var A=Math.max(1,function(e,t){var r=e.gl,n=e.resources,i=m(e,t);e.state.currentRenderItemId=-1,e.namedFramebuffers["histopyramid-sum"]||(e.namedFramebuffers["histopyramid-sum"]=n.framebuffer());var a=e.namedFramebuffers["histopyramid-sum"];return e.namedTextures["histopyramid-sum"]||(e.namedTextures["histopyramid-sum"]=Object(f.q)(r)?n.texture("image-int32","rgba","int","nearest"):n.texture("image-uint8","rgba","ubyte","nearest"),e.namedTextures["histopyramid-sum"].define(1,1)),e.namedTextures["histopyramid-sum"].attachFramebuffer(a,0),function(e){var t=e.gl,r=e.state;r.disable(t.CULL_FACE),r.disable(t.BLEND),r.disable(t.DEPTH_TEST),r.disable(t.SCISSOR_TEST),r.depthMask(!1),r.colorMask(!0,!0,!0,!0),r.clearColor(0,0,0,0)}(e),r.viewport(0,0,1,1),i.render(),r.finish(),e.readPixels(0,0,1,1,Object(f.q)(r)?g:h),e.unbindFramebuffer(),Object(f.q)(r)?g[0]:Object(l.a)(h[0],h[1],h[2])}(e,_[0].texture));return{pyramidTex:p,count:A,height:Math.ceil(A/Math.pow(2,o)),levels:o,scale:r}}var C,j,P=r(193),E=r(52);function A(){if(void 0!==C)return C;for(var e=(C=Object(E.c)(256,1,Uint8Array)).array,t=0,r=P.e.length;t<r;++t)e[t]=P.e[t].length/3;return C}function D(){if(void 0!==j)return j;for(var e=(j=Object(E.c)(4096,1,Uint8Array)).array,t=0,r=P.e.length;t<r;++t)for(var n=0;n<16;++n)n<P.e[t].length?e[16*t+n]=P.e[t][n]:e[16*t+n]=255;return j}var T=Object(n.__assign)(Object(n.__assign)({},c.b),{tTriCount:Object(o.i)("image-uint8","alpha","ubyte","nearest"),tVolumeData:Object(o.i)("texture","rgba","ubyte","nearest"),uIsoValue:Object(o.j)("f"),uGridDim:Object(o.j)("v3"),uGridTexDim:Object(o.j)("v3"),uScale:Object(o.j)("v2")});function I(e,t,r,o,l,f){if(e.namedComputeRenderables["active-voxels"]){var p=e.namedComputeRenderables["active-voxels"].values;u.e.update(p.uQuadScale,f),u.e.update(p.tVolumeData,t),u.e.updateIfChanged(p.uIsoValue,l),u.e.update(p.uGridDim,r),u.e.update(p.uGridTexDim,o),u.e.update(p.uScale,f),e.namedComputeRenderables["active-voxels"].update()}else e.namedComputeRenderables["active-voxels"]=function(e,t,r,o,l,f){var p=Object(n.__assign)(Object(n.__assign)({},c.c),{tTriCount:u.e.create(A()),uQuadScale:u.e.create(f),tVolumeData:u.e.create(t),uIsoValue:u.e.create(l),uGridDim:u.e.create(r),uGridTexDim:u.e.create(o),uScale:u.e.create(f)}),m=Object(n.__assign)({},T),h=Object(s.g)("active-voxels",d.a,"\nprecision highp float;\nprecision highp int;\nprecision highp sampler2D;\n\nuniform sampler2D tTriCount;\nuniform sampler2D tVolumeData;\n\nuniform float uIsoValue;\nuniform vec3 uGridDim;\nuniform vec3 uGridTexDim;\nuniform vec2 uScale;\n\n#include common\n\n// cube corners (excluding origin)\nconst vec3 c1 = vec3(1., 0., 0.);\nconst vec3 c2 = vec3(1., 1., 0.);\nconst vec3 c3 = vec3(0., 1., 0.);\nconst vec3 c4 = vec3(0., 0., 1.);\nconst vec3 c5 = vec3(1., 0., 1.);\nconst vec3 c6 = vec3(1., 1., 1.);\nconst vec3 c7 = vec3(0., 1., 1.);\n\nvec3 index3dFrom2d(vec2 coord) {\n    vec2 gridTexPos = coord * uGridTexDim.xy;\n    vec2 columnRow = ivec2Div(gridTexPos, uGridDim.xy);\n    vec2 posXY = gridTexPos - columnRow * uGridDim.xy;\n    float posZ = columnRow.y * intDiv(uGridTexDim.x, uGridDim.x) + columnRow.x;\n    return vec3(posXY, posZ);\n}\n\nvec4 texture3dFrom2dNearest(sampler2D tex, vec3 pos, vec3 gridDim, vec2 texDim) {\n    float zSlice = floor(pos.z * gridDim.z + 0.5); // round to nearest z-slice\n    float column = intDiv(intMod(zSlice * gridDim.x, texDim.x), gridDim.x);\n    float row = intDiv(zSlice * gridDim.x, texDim.x);\n    vec2 coord = (vec2(column * gridDim.x, row * gridDim.y) + (pos.xy * gridDim.xy)) / (texDim / uScale);\n    return texture2D(tex, coord);\n}\n\nvec4 voxel(vec3 pos) {\n    pos = min(max(vec3(0.0), pos), uGridDim - vec3(1.0));\n    return texture3dFrom2dNearest(tVolumeData, pos / uGridDim, uGridDim, uGridTexDim.xy);\n}\n\nvoid main(void) {\n    vec2 uv = gl_FragCoord.xy / uGridTexDim.xy;\n    vec3 posXYZ = index3dFrom2d(uv);\n\n    // get MC case as the sum of corners that are below the given iso level\n    float c = step(voxel(posXYZ).a, uIsoValue)\n        + 2. * step(voxel(posXYZ + c1).a, uIsoValue)\n        + 4. * step(voxel(posXYZ + c2).a, uIsoValue)\n        + 8. * step(voxel(posXYZ + c3).a, uIsoValue)\n        + 16. * step(voxel(posXYZ + c4).a, uIsoValue)\n        + 32. * step(voxel(posXYZ + c5).a, uIsoValue)\n        + 64. * step(voxel(posXYZ + c6).a, uIsoValue)\n        + 128. * step(voxel(posXYZ + c7).a, uIsoValue);\n    c *= step(c, 254.);\n\n    // handle out of bounds positions\n    posXYZ += 1.0;\n    posXYZ.xy += 1.0; // pixel padding (usually ok even if the texture has no padding)\n    if (posXYZ.x >= uGridDim.x || posXYZ.y >= uGridDim.y || posXYZ.z >= uGridDim.z)\n        c = 0.0;\n\n    // get total triangles to generate for calculated MC case from triCount texture\n    float totalTrianglesToGenerate = texture2D(tTriCount, vec2(intMod(c, 16.), floor(c / 16.)) / 16.).a;\n    gl_FragColor = vec4(vec3(totalTrianglesToGenerate * 3.0), c / 255.0);\n}\n"),g=Object(a.a)(e,"triangles",h,m,p);return Object(i.a)(g,p)}(e,t,r,o,l,f);return e.namedComputeRenderables["active-voxels"]}var M=Object(n.__assign)(Object(n.__assign)({},c.b),{tTriIndices:Object(o.i)("image-uint8","alpha","ubyte","nearest"),tActiveVoxelsPyramid:Object(o.i)("texture","rgba","float","nearest"),tActiveVoxelsBase:Object(o.i)("texture","rgba","float","nearest"),tVolumeData:Object(o.i)("texture","rgba","ubyte","nearest"),uIsoValue:Object(o.j)("f"),uSize:Object(o.j)("f"),uLevels:Object(o.j)("f"),uCount:Object(o.j)("f"),uGridDim:Object(o.j)("v3"),uGridTexDim:Object(o.j)("v3"),uGridTransform:Object(o.j)("m4"),uScale:Object(o.j)("v2"),dPackedGroup:Object(o.c)("boolean")});function k(e,t,r,o,l,f,p,m,h,g,v,b){if(e.namedComputeRenderables.isosurface){var y=e.namedComputeRenderables.isosurface.values;u.e.update(y.tActiveVoxelsPyramid,t),u.e.update(y.tActiveVoxelsBase,r),u.e.update(y.tVolumeData,o),u.e.updateIfChanged(y.uIsoValue,m),u.e.updateIfChanged(y.uSize,Math.pow(2,h)),u.e.updateIfChanged(y.uLevels,h),u.e.updateIfChanged(y.uCount,v),u.e.update(y.uGridDim,l),u.e.update(y.uGridTexDim,f),u.e.update(y.uGridTransform,p),u.e.update(y.uScale,g),u.e.update(y.dPackedGroup,b),e.namedComputeRenderables.isosurface.update()}else e.namedComputeRenderables.isosurface=function(e,t,r,o,l,f,p,m,h,g,v,b){var y=Object(n.__assign)(Object(n.__assign)({},c.c),{tTriIndices:u.e.create(D()),tActiveVoxelsPyramid:u.e.create(t),tActiveVoxelsBase:u.e.create(r),tVolumeData:u.e.create(o),uIsoValue:u.e.create(m),uSize:u.e.create(Math.pow(2,h)),uLevels:u.e.create(h),uCount:u.e.create(v),uGridDim:u.e.create(l),uGridTexDim:u.e.create(f),uGridTransform:u.e.create(p),uScale:u.e.create(g),dPackedGroup:u.e.create(b)}),_=Object(n.__assign)({},M),S=Object(s.g)("isosurface",d.a,"\nprecision highp float;\nprecision highp int;\nprecision highp sampler2D;\n\n#if __VERSION__ == 100\n    uniform sampler2D tActiveVoxelsPyramid;\n#else\n    precision highp isampler2D;\n    uniform isampler2D tActiveVoxelsPyramid;\n#endif\n\nuniform sampler2D tActiveVoxelsBase;\nuniform sampler2D tVolumeData;\nuniform sampler2D tTriIndices;\n\nuniform float uIsoValue;\nuniform float uLevels;\nuniform float uSize;\nuniform float uCount;\n\nuniform vec3 uGridDim;\nuniform vec3 uGridTexDim;\nuniform mat4 uGridTransform;\n\n// scale to volume data coord\nuniform vec2 uScale;\n\n#include common\n\n// cube corners (excluding origin)\nconst vec3 c1 = vec3(1., 0., 0.);\nconst vec3 c2 = vec3(1., 1., 0.);\nconst vec3 c3 = vec3(0., 1., 0.);\nconst vec3 c4 = vec3(0., 0., 1.);\nconst vec3 c5 = vec3(1., 0., 1.);\nconst vec3 c6 = vec3(1., 1., 1.);\nconst vec3 c7 = vec3(0., 1., 1.);\n\nvec3 index3dFrom2d(vec2 coord) {\n    vec2 gridTexPos = coord * uGridTexDim.xy;\n    vec2 columnRow = ivec2Div(gridTexPos, uGridDim.xy);\n    vec2 posXY = gridTexPos - columnRow * uGridDim.xy;\n    float posZ = columnRow.y * intDiv(uGridTexDim.x, uGridDim.x) + columnRow.x;\n    return vec3(posXY, posZ);\n}\n\nvec4 texture3dFrom2dNearest(sampler2D tex, vec3 pos, vec3 gridDim, vec2 texDim) {\n    float zSlice = floor(pos.z * gridDim.z + 0.5); // round to nearest z-slice\n    float column = intDiv(intMod(zSlice * gridDim.x, texDim.x), gridDim.x);\n    float row = intDiv(zSlice * gridDim.x, texDim.x);\n    vec2 coord = (vec2(column * gridDim.x, row * gridDim.y) + (pos.xy * gridDim.xy)) / (texDim / uScale);\n    return texture2D(tex, coord + 0.5 / (texDim / uScale));\n}\n\nvec4 voxel(vec3 pos) {\n    pos = min(max(vec3(0.0), pos), uGridDim - vec3(1.0));\n    return texture3dFrom2dNearest(tVolumeData, pos / uGridDim, uGridDim, uGridTexDim.xy);\n}\n\nvec4 voxelPadded(vec3 pos) {\n    pos = min(max(vec3(0.0), pos), uGridDim - vec3(vec2(2.0), 1.0)); // remove xy padding\n    return texture3dFrom2dNearest(tVolumeData, pos / uGridDim, uGridDim, uGridTexDim.xy);\n}\n\nint idot2(const in ivec2 a, const in ivec2 b) {\n    return a.x * b.x + a.y * b.y;\n}\n\nint idot4(const in ivec4 a, const in ivec4 b) {\n    return a.x * b.x + a.y * b.y + a.z * b.z + a.w * b.w;\n}\n\n#if __VERSION__ == 100\n    int pyramidVoxel(vec2 pos) {\n        return int(decodeFloatRGB(texture2D(tActiveVoxelsPyramid, pos / (vec2(1.0, 0.5) * uSize)).rgb));\n    }\n#else\n    int pyramidVoxel(vec2 pos) {\n        return texture2D(tActiveVoxelsPyramid, pos / (vec2(1.0, 0.5) * uSize)).r;\n    }\n#endif\n\nvec4 baseVoxel(vec2 pos) {\n    return texture2D(tActiveVoxelsBase, pos / uSize);\n}\n\nvoid main(void) {\n    // get 1D index\n    int vI = int(gl_FragCoord.x) + int(gl_FragCoord.y) * int(uSize);\n\n    // ignore 1D indices outside of the grid\n    if(vI >= int(uCount)) discard;\n\n    ivec2 offset = ivec2(int(uSize) - 2, 0);\n\n    int start = 0;\n    ivec4 starts = ivec4(0);\n    ivec4 ends = ivec4(0);\n    int diff = 2;\n    ivec4 m = ivec4(0);\n    ivec2 position = ivec2(0);\n    ivec4 vI4 = ivec4(vI);\n\n    ivec2 relativePosition = ivec2(0);\n    int end = 0;\n    ivec2 pos1 = ivec2(0);\n    ivec2 pos2 = ivec2(0);\n    ivec2 pos3 = ivec2(0);\n    ivec2 pos4 = ivec2(0);\n    ivec3 vI3 = ivec3(vI);\n    ivec3 mask = ivec3(0);\n\n    // traverse the different levels of the pyramid\n    for(int i = 1; i < 14; i++) {\n        if(float(i) >= uLevels) break;\n\n        offset.x -= diff;\n        diff *= 2;\n        relativePosition = position + offset;\n\n        end = start + pyramidVoxel(vec2(relativePosition));\n        pos1 = ivec2(relativePosition);\n        starts.x = start;\n        ends.x = end;\n        pos2 = ivec2(relativePosition + ivec2(1, 0));\n        starts.y = ends.x;\n        ends.y = ends.x + pyramidVoxel(vec2(pos2));\n        pos3 = relativePosition + ivec2(0, 1);\n        starts.z = ends.y;\n        ends.z = ends.y + pyramidVoxel(vec2(pos3));\n        pos4 = relativePosition + ivec2(1, 1);\n        starts.w = ends.z;\n        mask = ivec3(greaterThanEqual(vI3, starts.rgb)) * ivec3(lessThan(vI3, ends.rgb));\n        m = ivec4(mask, 1 - int(any(bvec3(mask))));\n\n        relativePosition = m.x * pos1 + m.y * pos2 + m.z * pos3 + m.w * pos4;\n        start = idot4(m, starts);\n        position = 2 * (relativePosition - offset);\n    }\n\n    end = start + int(baseVoxel(vec2(position)).r * 255.0);\n    pos1 = position;\n    starts.x = start;\n    ends.x = end;\n    pos2 = position + ivec2(1, 0);\n    starts.y = ends.x;\n    ends.y = ends.x + int(baseVoxel(vec2(pos2)).r * 255.0);\n    pos3 = position + ivec2(0, 1);\n    starts.z = ends.y;\n    ends.z = ends.y + int(baseVoxel(vec2(pos3)).r * 255.0);\n    pos4 = position + ivec2(1, 1);\n    starts.w = ends.z;\n    mask = ivec3(greaterThanEqual(vI3, starts.rgb)) * ivec3(lessThan(vI3, ends.rgb));\n    m = ivec4(mask, 1 - int(any(bvec3(mask))));\n    position = m.x * pos1 + m.y * pos2 + m.z * pos3 + m.w * pos4;\n\n    vec2 coord2d = (vec2(position) / uSize) / uScale;\n    vec3 coord3d = floor(index3dFrom2d(coord2d) + 0.5);\n\n    float edgeIndex = floor(baseVoxel(vec2(position)).a * 255.0 + 0.5);\n\n    // current vertex for the up to 15 MC cases\n    int currentVertex = vI - idot4(m, starts);\n\n    // get index into triIndices table\n    int mcIndex = 16 * int(edgeIndex) + currentVertex;\n    vec4 mcData = texture2D(tTriIndices, vec2(imod(mcIndex, 64), mcIndex / 64) / 64.);\n\n    // bit mask to avoid conditionals (see comment below) for getting MC case corner\n    vec4 m0 = vec4(floor(mcData.a * 255.0 + 0.5));\n\n    // get edge value masks\n    vec4 m1 = vec4(equal(m0, vec4(0., 1., 2., 3.)));\n    vec4 m2 = vec4(equal(m0, vec4(4., 5., 6., 7.)));\n    vec4 m3 = vec4(equal(m0, vec4(8., 9., 10., 11.)));\n\n    // apply bit masks\n    vec3 b0 = coord3d +\n                m1.y * c1 +\n                m1.z * c2 +\n                m1.w * c3 +\n                m2.x * c4 +\n                m2.y * c5 +\n                m2.z * c6 +\n                m2.w * c7 +\n                m3.y * c1 +\n                m3.z * c2 +\n                m3.w * c3;\n    vec3 b1 = coord3d +\n                m1.x * c1 +\n                m1.y * c2 +\n                m1.z * c3 +\n                m2.x * c5 +\n                m2.y * c6 +\n                m2.z * c7 +\n                m2.w * c4 +\n                m3.x * c4 +\n                m3.y * c5 +\n                m3.z * c6 +\n                m3.w * c7;\n\n    // the conditionals that are avoided by above bitmasks\n    // vec3 b0 = coord3d;\n    // vec3 b1 = coord3d;\n    // if (mcIndex == 0.0) {\n    //     b1 += c1;\n    // } else if (mcIndex == 1.0) {\n    //     b0 += c1; b1 += c2;\n    // } else if (mcIndex == 2.0) {\n    //     b0 += c2; b1 += c3;\n    // } else if (mcIndex == 3.0) {\n    //     b0 += c3;\n    // } else if (mcIndex == 4.0) {\n    //     b0 += c4; b1 += c5;\n    // } else if (mcIndex == 5.0) {\n    //     b0 += c5; b1 += c6;\n    // } else if (mcIndex == 6.0) {\n    //     b0 += c6; b1 += c7;\n    // } else if (mcIndex == 7.0) {\n    //     b0 += c7; b1 += c4;\n    // } else if (mcIndex == 8.0) {\n    //     b1 += c4;\n    // } else if (mcIndex == 9.0) {\n    //     b0 += c1; b1 += c5;\n    // } else if (mcIndex == 10.0) {\n    //     b0 += c2; b1 += c6;\n    // } else if (mcIndex == 11.0) {\n    //     b0 += c3; b1 += c7;\n    // }\n    // b0 = floor(b0 + 0.5);\n    // b1 = floor(b1 + 0.5);\n\n    vec4 d0 = voxel(b0);\n    vec4 d1 = voxel(b1);\n\n    float v0 = d0.a;\n    float v1 = d1.a;\n\n    float t = (uIsoValue - v0) / (v0 - v1);\n    gl_FragData[0].xyz = (uGridTransform * vec4(b0 + t * (b0 - b1), 1.0)).xyz;\n\n    // group id\n    #if __VERSION__ == 100\n        // webgl1 does not support 'flat' interpolation (i.e. no interpolation)\n        // so we ensure a constant group id per triangle here\n        #ifdef dPackedGroup\n            gl_FragData[1] = vec4(voxel(coord3d).rgb, 1.0);\n        #else\n            vec3 gridDim = uGridDim - vec3(1.0, 1.0, 0.0); // remove xy padding\n            float group = coord3d.z + coord3d.y * gridDim.z + coord3d.x * gridDim.z * gridDim.y;\n            gl_FragData[1] = vec4(group > 16777215.5 ? vec3(1.0) : encodeFloatRGB(group), 1.0);\n        #endif\n    #else\n        #ifdef dPackedGroup\n            gl_FragData[1] = vec4(t < 0.5 ? d0.rgb : d1.rgb, 1.0);\n        #else\n            vec3 b = t < 0.5 ? b0 : b1;\n            vec3 gridDim = uGridDim - vec3(1.0, 1.0, 0.0); // remove xy padding\n            float group = b.z + b.y * gridDim.z + b.x * gridDim.z * gridDim.y;\n            gl_FragData[1] = vec4(group > 16777215.5 ? vec3(1.0) : encodeFloatRGB(group), 1.0);\n        #endif\n    #endif\n\n    // normals from gradients\n    vec3 n0 = -normalize(vec3(\n        voxelPadded(b0 - c1).a - voxelPadded(b0 + c1).a,\n        voxelPadded(b0 - c3).a - voxelPadded(b0 + c3).a,\n        voxelPadded(b0 - c4).a - voxelPadded(b0 + c4).a\n    ));\n    vec3 n1 = -normalize(vec3(\n        voxelPadded(b1 - c1).a - voxelPadded(b1 + c1).a,\n        voxelPadded(b1 - c3).a - voxelPadded(b1 + c3).a,\n        voxelPadded(b1 - c4).a - voxelPadded(b1 + c4).a\n    ));\n    mat3 normalMatrix = transpose3(inverse3(mat3(uGridTransform)));\n    gl_FragData[2].xyz = normalMatrix * -vec3(\n        n0.x + t * (n0.x - n1.x),\n        n0.y + t * (n0.y - n1.y),\n        n0.z + t * (n0.z - n1.z)\n    );\n}\n",{drawBuffers:"required"}),x=Object(a.a)(e,"triangles",S,_,y);return Object(i.a)(x,y)}(e,t,r,o,l,f,p,m,h,g,v,b);return e.namedComputeRenderables.isosurface}function B(e,t,r,n,i,a,o,s,u,c,l){var d=function(e,t,r,n,i,a){var o=e.gl,s=e.resources,u=t.getWidth(),c=t.getHeight();e.namedFramebuffers["active-voxels"]||(e.namedFramebuffers["active-voxels"]=s.framebuffer());var l=e.namedFramebuffers["active-voxels"];l.bind(),e.namedTextures["active-voxels"]||(e.namedTextures["active-voxels"]=s.texture("image-uint8","rgba","ubyte","nearest"));var d=e.namedTextures["active-voxels"];d.define(u,c);var f=I(e,t,r,n,i,a);return e.state.currentRenderItemId=-1,d.attachFramebuffer(l,0),function(e){var t=e.gl,r=e.state;r.disable(t.CULL_FACE),r.disable(t.BLEND),r.disable(t.DEPTH_TEST),r.enable(t.SCISSOR_TEST),r.depthMask(!1),r.colorMask(!0,!0,!0,!0),r.clearColor(0,0,0,0)}(e),o.viewport(0,0,u,c),o.scissor(0,0,u,c),o.clear(o.COLOR_BUFFER_BIT),o.scissor(0,0,n[0],n[1]),f.render(),o.finish(),d}(e,t,r,n,o,i);return function(e,t,r,n,i,a,o,s,u,c,l,d){var p=e.gl,m=e.resources,h=e.extensions,g=n.pyramidTex,v=n.height,b=n.levels,y=n.scale,_=n.count,S=g.getWidth();e.namedFramebuffers.isosurface||(e.namedFramebuffers.isosurface=m.framebuffer());var x=e.namedFramebuffers.isosurface;Object(f.q)(p)?(c||(c=h.colorBufferHalfFloat&&h.textureHalfFloat?m.texture("image-float16","rgba","fp16","nearest"):m.texture("image-float32","rgba","float","nearest")),l||(l=m.texture("image-uint8","rgba","ubyte","nearest")),d||(d=h.colorBufferHalfFloat&&h.textureHalfFloat?m.texture("image-float16","rgba","fp16","nearest"):m.texture("image-float32","rgba","float","nearest"))):(c||(c=m.texture("image-float32","rgba","float","nearest")),l||(l=m.texture("image-float32","rgba","float","nearest")),d||(d=m.texture("image-float32","rgba","float","nearest"))),c.define(S,v),l.define(S,v),d.define(S,v),c.attachFramebuffer(x,0),l.attachFramebuffer(x,1),d.attachFramebuffer(x,2);var O=k(e,g,t,r,i,a,o,s,b,y,_,u);e.state.currentRenderItemId=-1;var w=e.extensions.drawBuffers;if(!w)throw new Error("need WebGL draw buffers");return x.bind(),w.drawBuffers([w.COLOR_ATTACHMENT0,w.COLOR_ATTACHMENT1,w.COLOR_ATTACHMENT2]),function(e){var t=e.gl,r=e.state;r.disable(t.CULL_FACE),r.disable(t.BLEND),r.disable(t.DEPTH_TEST),r.disable(t.SCISSOR_TEST),r.depthMask(!1),r.colorMask(!0,!0,!0,!0),r.clearColor(0,0,0,0)}(e),p.viewport(0,0,S,v),p.clear(p.COLOR_BUFFER_BIT),O.render(),p.flush(),{vertexTexture:c,groupTexture:l,normalTexture:d,vertexCount:_}}(e,d,t,w(e,d,i,n),r,n,a,o,s,u,c,l)}},function(e,t,r){"use strict";r.d(t,"a",(function(){return V}));var n=r(0),i=r(2),a=r(41),o=r(55),s=r(4),u=r(1),c=r(23),l=r(6),d=r(38),f=r(106),p=r(112),m=r(49),h=r(53),g=r(208),v=r(9);function b(e,t,r,i,a,o){return Object(n.__awaiter)(this,void 0,void 0,(function(){var c,l,m,h,g,b,y,_,S,x,O,w,C,j,P,E,A;return Object(n.__generator)(this,(function(n){return 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this.entryMap.get(e)},t.prototype.remove=function(e){var t=this.entryMap.get(e);t&&(this.entryMap.delete(e),this.updateState({current:this.state.current===e?void 0:this.state.current,entries:this.state.entries.delete(this.getIndex(t))}),this.events.changed.next())},t.prototype.add=function(e){this.entryMap.set(e.snapshot.id,e),this.updateState({current:e.snapshot.id,entries:this.state.entries.push(e)}),this.events.changed.next()},t.prototype.replace=function(e,r){var n=this.getEntry(e);if(n){var i=this.getIndex(n),a=t.Entry(r,{name:n.name,description:n.description});this.entryMap.set(r.id,a),this.updateState({current:a.snapshot.id,entries:this.state.entries.set(i,a)}),this.events.changed.next()}},t.prototype.move=function(e,t){var r=this.state.entries.size;if(!(r<2)){var n=this.getEntry(e);if(n){var i=this.getIndex(n),a=(i+t)%r;a<0&&(a+=r);var o=this.state.entries.get(a),s=this.state.entries.asMutable();s.set(a,n),s.set(i,o),this.updateState({current:n.snapshot.id,entries:s.asImmutable()}),this.events.changed.next()}}},t.prototype.clear=function(){0!==this.state.entries.size&&(this.entryMap.clear(),this.updateState({current:void 0,entries:Object(i.List)()}),this.events.changed.next())},t.prototype.setCurrent=function(e){var t=this.getEntry(e);return t&&(this.updateState({current:e}),this.events.changed.next()),t&&t.snapshot},t.prototype.getNextId=function(e,t){var r=this.state.entries.size;if(!e){if(0===r)return;var n=-1===t?r-1:0;return this.state.entries.get(n).snapshot.id}var i=this.getEntry(e);if(i){var a=this.getIndex(i);if(!(a<0))return(a=(a+t)%r)<0&&(a+=r),this.state.entries.get(a).snapshot.id}},t.prototype.setStateSnapshot=function(e){return Object(n.__awaiter)(this,void 0,void 0,(function(){var r,a,o,s,u,c,d;return Object(n.__generator)(this,(function(n){switch(n.label){case 0:for(e.version,l.a,this.clear(),r=Object(i.List)().asMutable(),a=0,o=e.entries;a<o.length;a++)s=o[a],this.entryMap.set(s.snapshot.id,s),r.push(s);return u=e.current?e.current:e.entries.length>0?e.entries[0].snapshot.id:void 0,this.updateState({current:u,entries:r.asImmutable(),isPlaying:!1,nextSnapshotDelayInMs:e.playback?e.playback.nextSnapshotDelayInMs:t.DefaultNextSnapshotDelayInMs}),this.events.changed.next(),u?(c=this.getEntry(u),(d=c&&c.snapshot)?[4,this.plugin.state.setSnapshot(d)]:[2]):[2];case 1:return n.sent(),e.playback&&e.playback.isPlaying&&this.play(!0),[2,d]}}))}))},t.prototype.syncCurrent=function(e){var r=this.plugin.state.getSnapshot(null==e?void 0:e.params);0!==this.state.entries.size&&this.state.current?this.replace(this.state.current,r):this.add(t.Entry(r,{name:null==e?void 0:e.name,description:null==e?void 0:e.description}))},t.prototype.getStateSnapshot=function(e){return this.syncCurrent(e),{timestamp:+new Date,version:l.a,name:e&&e.name,description:e&&e.description,current:this.state.current,playback:{isPlaying:!(!e||!e.playOnLoad),nextSnapshotDelayInMs:this.state.nextSnapshotDelayInMs},entries:this.state.entries.valueSeq().toArray()}},t.prototype.serialize=function(e){return Object(n.__awaiter)(this,void 0,void 0,(function(){var t,r,i,a,u,c,l,d,f,p,m,h,g,v,b;return Object(n.__generator)(this,(function(n){switch(n.label){case 0:return t=JSON.stringify(this.getStateSnapshot({params:null==e?void 0:e.params}),null,2),(null==e?void 0:e.type)&&"json"!==e.type&&"molj"!==e.type?[3,1]:[2,new Blob([t],{type:"application/json;charset=utf-8"})];case 1:r=new Uint8Array(Object(o.a)(t)),Object(o.c)(r,0,t),i={"state.json":r},a=[],u=0,c=this.plugin.managers.asset.assets,n.label=2;case 2:return u<c.length?(l=c[u],d=l.asset,f=l.file,a.push([d.id,d]),p=i,m="assets/"+d.id,h=Uint8Array.bind,[4,f.arrayBuffer()]):[3,5];case 3:p[m]=new(h.apply(Uint8Array,[void 0,n.sent()])),n.label=4;case 4:return u++,[3,2];case 5:return a.length>0&&(g=JSON.stringify(a,null,2),v=new Uint8Array(Object(o.a)(g)),Object(o.c)(v,0,g),i["assets.json"]=v),b=Object(s.c)(i),[2,new Blob([b],{type:"application/zip"})]}}))}))},t.prototype.open=function(e){return Object(n.__awaiter)(this,void 0,void 0,(function(){var r,i,a,o,s,l,d,f,p,m,h,g,v,b,y,_;return Object(n.__generator)(this,(function(n){switch(n.label){case 0:return n.trys.push([0,8,,9]),(r=e.name.toLowerCase()).endsWith("json")||r.endsWith("molj")?[4,this.plugin.runTask(Object(u.c)(e,"string"))]:[3,2];case 1:return i=n.sent(),y=JSON.parse(i),t.isStateSnapshot(y)?[2,this.setStateSnapshot(y)]:t.isStateSnapshot(y.data)?[2,this.setStateSnapshot(y.data)]:(this.plugin.state.setSnapshot(y),[3,7]);case 2:return[4,this.plugin.runTask(Object(u.c)(e,"zip"))];case 3:return i=n.sent(),a=Object.create(null),Object(c.c)(i,(function(e,t){if("state.json"!==t&&"assets.json"!==t){var r=t.substring(t.indexOf("/")+1);a[r]=new File([e],r)}})),o=new File([i["state.json"]],"state.json"),[4,this.plugin.runTask(Object(u.c)(o,"string"))];case 4:return s=n.sent(),i["assets.json"]?(l=new File([i["assets.json"]],"assets.json"),p=(f=JSON).parse,[4,this.plugin.runTask(Object(u.c)(l,"string"))]):[3,6];case 5:for(d=p.apply(f,[n.sent()]),m=0,h=d;m<h.length;m++)g=h[m],v=g[0],b=g[1],this.plugin.managers.asset.set(b,a[v]);n.label=6;case 6:return y=JSON.parse(s),[2,this.setStateSnapshot(y)];case 7:return[3,9];case 8:return _=n.sent(),this.plugin.log.error("Reading state: "+_),[3,9];case 9:return[2]}}))}))},t.prototype.play=function(e){if(void 0===e&&(e=!1),this.updateState({isPlaying:!0}),e){var t=this.getEntry(this.state.current);if(!t)return void this.next();this.events.changed.next();var r=t.snapshot,n=void 0!==r.durationInMs?r.durationInMs:this.state.nextSnapshotDelayInMs;this.timeoutHandle=setTimeout(this.next,n)}else this.next()},t.prototype.stop=function(){this.updateState({isPlaying:!1}),void 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a=this.drawPass.depthTexturePrimitives;e.clear(!1),e.renderPick(r.primitives,t,i,null),e.renderPick(r.volumes,t,i,a),e.renderPick(n.handle.scene,t,i,null)},e.prototype.render=function(e,t,r,n){e.update(t),this.objectPickTarget.bind(),this.renderVariant(e,t,r,n,"pickObject"),this.instancePickTarget.bind(),this.renderVariant(e,t,r,n,"pickInstance"),this.groupPickTarget.bind(),this.renderVariant(e,t,r,n,"pickGroup"),this.depthPickTarget.bind(),this.renderVariant(e,t,r,n,"depth")},e}(),c=function(){function e(e,t,r,n,i,a){this.webgl=e,this.renderer=t,this.scene=r,this.helper=n,this.pickPass=i,this.dirty=!0,this.viewport=Object(o.a)(),this.setViewport(a.x,a.y,a.width,a.height)}return e.prototype.setupBuffers=function(){var e=this.pickWidth*this.pickHeight*4;this.objectBuffer&&this.objectBuffer.length===e||(this.objectBuffer=new Uint8Array(e),this.instanceBuffer=new Uint8Array(e),this.groupBuffer=new Uint8Array(e),this.depthBuffer=new 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0===n.length?this._empty:n},t.prototype.sync=function(){this.updateState({labels:this.getTransforms(o.StateTransforms.Representation.StructureSelectionsLabel3D),distances:this.getTransforms(o.StateTransforms.Representation.StructureSelectionsDistance3D),angles:this.getTransforms(o.StateTransforms.Representation.StructureSelectionsAngle3D),dihedrals:this.getTransforms(o.StateTransforms.Representation.StructureSelectionsDihedral3D),orientations:this.getTransforms(o.StateTransforms.Representation.StructureSelectionsOrientation3D)})&&this.stateUpdated()},t}(c.b)},function(e,t,r){"use strict";r.d(t,"a",(function(){return l}));var n=r(0),i=r(23),a=r(4),o=r(41),s=r(51),u=r(87),c=r(2),l=function(e){function t(r,i){void 0===i&&(i={});var a=e.call(this,{props:Object(n.__assign)(Object(n.__assign)({},c.ParamDefinition.getDefaultValues(t.Params)),i)})||this;return a.plugin=r,a._props=c.ParamDefinition.getDefaultValues(t.Params),a.events={propsUpdated:a.ev()},a.lociSelects=new t.LociSelectManager(r,a._props),a.lociHighlights=new t.LociHighlightManager(r,a._props),a}return Object(n.__extends)(t,e),Object.defineProperty(t.prototype,"props",{get:function(){return Object(n.__assign)({},this.state.props)},enumerable:!1,configurable:!0}),t.prototype.setProps=function(e){var t=this.props,r=Object(n.__assign)(Object(n.__assign)({},this.state.props),e);Object(u.d)(t,r)||(this.updateState({props:r}),this.lociSelects.setProps(r),this.lociHighlights.setProps(r),this.events.propsUpdated.next())},t}(r(116).b);!function(e){e.Params={granularity:c.ParamDefinition.Select("residue",i.Loci.GranularityOptions,{label:"Picking Level",description:"Controls if selections are expanded upon picking to whole residues, chains, structures, instances, or left as atoms and coarse elements"})};var t=function(){function t(t,r){void 0===r&&(r={}),this.ctx=t,this.providers=[],this.props=c.ParamDefinition.getDefaultValues(e.Params),this.sel=t.managers.structure.selection,this.setProps(r)}return t.prototype.setProps=function(e){Object.assign(this.props,e)},t.prototype.addProvider=function(e){this.providers.push(e)},t.prototype.removeProvider=function(e){this.providers=this.providers.filter((function(t){return t!==e}))},t.prototype.normalizedLoci=function(e,t){void 0===t&&(t=!0);var r=e.loci,n=e.repr,a=t?this.props.granularity:void 0;return{loci:i.Loci.normalize(r,a),repr:n}},t.prototype.mark=function(e,t){if(!i.Loci.isEmpty(e.loci))for(var r=0,n=this.providers;r<n.length;r++){(0,n[r])(e,t)}},t}();e.LociMarkManager=t;var r=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.prev=[],t.clearHighlights=function(){for(var e=0,r=t.prev;e<r.length;e++){var n=r[e];t.mark(n,s.a.RemoveHighlight)}t.prev.length=0},t}return Object(n.__extends)(t,e),t.prototype.isHighlighted=function(e){for(var t=0,r=this.prev;t<r.length;t++){var n=r[t];if(o.a.Loci.areEqual(n,e))return!0}return!1},t.prototype.addHighlight=function(e){this.mark(e,s.a.Highlight),this.prev.push(e)},t.prototype.highlight=function(e,t){void 0===t&&(t=!0);var r=this.normalizedLoci(e,t);this.isHighlighted(r)||this.addHighlight(r)},t.prototype.highlightOnly=function(e,t){void 0===t&&(t=!0);var r=this.normalizedLoci(e,t);this.isHighlighted(r)||(this.clearHighlights(),this.addHighlight(r))},t.prototype.highlightOnlyExtend=function(e,t){void 0===t&&(t=!0);var r=this.normalizedLoci(e,t);if(a.StructureElement.Loci.is(r.loci)){var n={loci:this.sel.tryGetRange(r.loci)||r.loci,repr:r.repr};this.isHighlighted(n)||(this.clearHighlights(),this.addHighlight(n))}},t}(t);e.LociHighlightManager=r;var u=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return Object(n.__extends)(t,e),t.prototype.toggle=function(t,r){if(void 0===r&&(r=!0),!i.Loci.isEmpty(t.loci)){var n=this.normalizedLoci(t,r);a.StructureElement.Loci.is(n.loci)?this.toggleSel(n):e.prototype.mark.call(this,n,s.a.Toggle)}},t.prototype.toggleExtend=function(e,t){if(void 0===t&&(t=!0),!i.Loci.isEmpty(e.loci)){var r=this.normalizedLoci(e,t);if(a.StructureElement.Loci.is(r.loci)){var n=this.sel.tryGetRange(r.loci)||r.loci;this.toggleSel({loci:n,repr:r.repr})}}},t.prototype.select=function(e,t){void 0===t&&(t=!0);var r=this.normalizedLoci(e,t);a.StructureElement.Loci.is(r.loci)&&this.sel.modify("add",r.loci),this.mark(r,s.a.Select)},t.prototype.selectJoin=function(e,t){void 0===t&&(t=!0);var r=this.normalizedLoci(e,t);a.StructureElement.Loci.is(r.loci)&&this.sel.modify("intersect",r.loci),this.mark(r,s.a.Select)},t.prototype.selectOnly=function(e,t){void 0===t&&(t=!0);var r=this.normalizedLoci(e,t);a.StructureElement.Loci.is(r.loci)&&(this.deselect({loci:a.Structure.toStructureElementLoci(r.loci.structure),repr:r.repr},!1),this.sel.modify("set",r.loci)),this.mark(r,s.a.Select)},t.prototype.deselect=function(e,t){void 0===t&&(t=!0);var r=this.normalizedLoci(e,t);a.StructureElement.Loci.is(r.loci)&&this.sel.modify("remove",r.loci),this.mark(r,s.a.Deselect)},t.prototype.deselectAll=function(){this.sel.clear(),this.mark({loci:i.EveryLoci},s.a.Deselect)},t.prototype.deselectAllOnEmpty=function(e){Object(i.isEmptyLoci)(e.loci)&&this.deselectAll()},t.prototype.mark=function(t,r){var n=t.loci;i.Loci.isEmpty(n)||(a.StructureElement.Loci.is(n)?(e.prototype.mark.call(this,{loci:a.Structure.Loci(n.structure)},s.a.Deselect),e.prototype.mark.call(this,{loci:this.sel.getLoci(n.structure)},s.a.Select)):e.prototype.mark.call(this,t,r))},t.prototype.toggleSel=function(e){this.sel.has(e.loci)?(this.sel.modify("remove",e.loci),this.mark(e,s.a.Deselect)):(this.sel.modify("add",e.loci),this.mark(e,s.a.Select))},t}(t);e.LociSelectManager=u}(l||(l={}))},function(e,t,r){"use strict";r.r(t),r.d(t,"VolumeStreamingControls",(function(){return y})),r.d(t,"VolumeSourceControls",(function(){return _}));var n=r(0),i=r(3),a=r(284),o=r(392),s=r(234),u=r(164),c=r(308),l=r(13),d=r(33),f=r(56),p=r(18),m=r(318),h=r(189),g=r(195),v=r(27),b=r(15),y=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return Object(n.__extends)(t,e),t.prototype.defaultState=function(){return{header:"Volume Streaming",isCollapsed:!1,isBusy:!1,isHidden:!0,brand:{accent:"cyan",svg:b.BlurOnSvg}}},t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.managers.structure.hierarchy.behaviors.selection,(function(){e.setState({isHidden:!e.canEnable(),description:a.StructureHierarchyManager.getSelectedStructuresDescription(e.plugin)})})),this.subscribe(this.plugin.state.events.cell.stateUpdated,(function(t){l.StateTransform.hasTag(t.cell.transform,u.a.RootTag)&&e.forceUpdate()})),this.subscribe(this.plugin.behaviors.state.isBusy,(function(t){e.setState({isBusy:t})}))},Object.defineProperty(t.prototype,"pivot",{get:function(){return this.plugin.managers.structure.hierarchy.selection.structures[0]},enumerable:!1,configurable:!0}),t.prototype.canEnable=function(){var e,t;if(1!==this.plugin.managers.structure.hierarchy.selection.structures.length)return!1;var r=this.pivot.cell;return!!r.obj&&!!(null===(t=(e=c.InitVolumeStreaming.definition).isApplicable)||void 0===t?void 0:t.call(e,r.obj,r.transform,this.plugin))},t.prototype.renderEnable=function(){var e,t=this.pivot;if(!t.cell.parent)return null;var r=l.StateSelection.findTagInSubtree(t.cell.parent.tree,this.pivot.cell.transform.ref,u.a.RootTag),n=r&&t.cell.parent.cells.get(r),a=n&&"error"===n.status?{header:"Error enabling",icon:b.ErrorSvg,title:n.errorText}:n&&0===(null===(e=n.obj)||void 0===e?void 0:e.data.entries.length)?{header:"Error enabling",icon:b.ErrorSvg,title:"No entry for streaming found"}:{header:"Enable",icon:b.CheckSvg,title:"Enable"};return i.createElement(m.a,{state:t.cell.parent,action:c.InitVolumeStreaming,initiallyCollapsed:!0,nodeRef:t.cell.transform.ref,simpleApply:a})},t.prototype.renderParams=function(){var e,t,r,n,a,o=this.pivot;if(!o.cell.parent)return null;var u="selection-box"===(null===(t=null===(e=o.volumeStreaming)||void 0===e?void 0:e.cell.transform.params)||void 0===t?void 0:t.entry.params.view.name)&&(null===(a=null===(n=null===(r=this.plugin.state.behaviors.cells.get(s.FocusLoci.id))||void 0===r?void 0:r.params)||void 0===n?void 0:n.values)||void 0===a?void 0:a.bindings);return i.createElement(i.Fragment,null,i.createElement(h.UpdateTransformControl,{state:o.cell.parent,transform:o.volumeStreaming.cell.transform,customHeader:"none",noMargin:!0}),u&&i.createElement(p.ExpandGroup,{header:"Controls Help"},i.createElement(g.BindingsHelp,{bindings:u})))},t.prototype.renderControls=function(){var e=this.pivot;return e?e.volumeStreaming?this.renderParams():this.renderEnable():null},t}(d.CollapsableControls),_=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.item=function(e){var r,n=t.plugin.managers.volume.hierarchy.selection;return{kind:"item",label:(null===(r=e.cell.obj)||void 0===r?void 0:r.label)||"Volume"||e.kind,selected:n===e,value:e}},t.selectCurrent=function(e){t.toggleHierarchy(),e&&t.plugin.managers.volume.hierarchy.setCurrent(e.value)},t.selectAdd=function(e){e&&(t.setState({show:void 0}),e.value())},t.toggleHierarchy=function(){return t.setState({show:"hierarchy"!==t.state.show?"hierarchy":void 0})},t.toggleAddRepr=function(){return t.setState({show:"add-repr"!==t.state.show?"add-repr":void 0})},t}return Object(n.__extends)(t,e),t.prototype.defaultState=function(){return{header:"Volume",isCollapsed:!1,isBusy:!1,isHidden:!0,brand:{accent:"purple",svg:b.BlurOnSvg}}},t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.managers.volume.hierarchy.behaviors.selection,(function(t){e.setState({isHidden:0===t.hierarchy.volumes.length})})),this.subscribe(this.plugin.behaviors.state.isBusy,(function(t){e.setState({isBusy:t})}))},Object.defineProperty(t.prototype,"hierarchyItems",{get:function(){for(var e=[],t=0,r=this.plugin.managers.volume.hierarchy.current.volumes;t<r.length;t++){var n=r[t];e.push(this.item(n))}return e},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"addActions",{get:function(){var e=this.plugin.managers.volume.hierarchy,t=e.selection;return Object(n.__spreadArrays)(o.a.getRepresentationTypes(this.plugin,t).map((function(r){return f.a.Item(r[1],(function(){return e.addRepresentation(t,r[0])}))})))},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"isEmpty",{get:function(){return 0===this.plugin.managers.volume.hierarchy.current.volumes.length},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"label",{get:function(){var e,t=this.plugin.managers.volume.hierarchy.selection;return t?(null===(e=null==t?void 0:t.cell.obj)||void 0===e?void 0:e.label)||"Volume":"Nothing Selected"},enumerable:!1,configurable:!0}),t.prototype.renderControls=function(){var e=this.state.isBusy||this.isEmpty,t=this.label,r=this.plugin.managers.volume.hierarchy.selection;return i.createElement(i.Fragment,null,i.createElement("div",{className:"msp-flex-row",style:{marginTop:"1px"}},i.createElement(p.Button,{noOverflow:!0,flex:!0,onClick:this.toggleHierarchy,disabled:e,title:t},t),!this.isEmpty&&i.createElement(p.IconButton,{svg:b.AddSvg,onClick:this.toggleAddRepr,title:"Apply a structure presets to the current hierarchy.",toggleState:"add-repr"===this.state.show,disabled:e})),"hierarchy"===this.state.show&&i.createElement(f.a,{items:this.hierarchyItems,onSelect:this.selectCurrent}),"add-repr"===this.state.show&&i.createElement(f.a,{items:this.addActions,onSelect:this.selectAdd}),r&&r.representations.length>0&&i.createElement("div",{style:{marginTop:"6px"}},r.representations.map((function(e){return i.createElement(S,{key:e.cell.transform.ref,representation:e})}))))},t}(d.CollapsableControls),S=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={action:void 0},t.remove=function(){return t.plugin.managers.volume.hierarchy.remove([t.props.representation],!0)},t.toggleVisible=function(e){e.preventDefault(),e.currentTarget.blur(),t.plugin.managers.volume.hierarchy.toggleVisibility([t.props.representation])},t.toggleUpdate=function(){return t.setState({action:"update"===t.state.action?void 0:"update"})},t.highlight=function(e){e.preventDefault(),t.props.representation.cell.parent&&v.PluginCommands.Interactivity.Object.Highlight(t.plugin,{state:t.props.representation.cell.parent,ref:t.props.representation.cell.transform.ref})},t.clearHighlight=function(e){e.preventDefault(),v.PluginCommands.Interactivity.ClearHighlights(t.plugin)},t.focus=function(){var e,r=t.props.representation,n=null===(e=t.props.representation.cell.obj)||void 0===e?void 0:e.data.repr.renderObjects;r.cell.state.isHidden&&t.plugin.managers.volume.hierarchy.toggleVisibility([t.props.representation],"show"),t.plugin.managers.camera.focusRenderObjects(n,{extraRadius:1})},t}return Object(n.__extends)(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.state.events.cell.stateUpdated,(function(t){l.State.ObjectEvent.isCell(t,e.props.representation.cell)&&e.forceUpdate()}))},t.prototype.render=function(){var e,t,r,n=this.props.representation.cell;return i.createElement(i.Fragment,null,i.createElement("div",{className:"msp-flex-row"},i.createElement(p.Button,{noOverflow:!0,className:"msp-control-button-label",title:(null===(e=n.obj)||void 0===e?void 0:e.label)+". Click to focus.",onClick:this.focus,onMouseEnter:this.highlight,onMouseLeave:this.clearHighlight,style:{textAlign:"left"}},null===(t=n.obj)||void 0===t?void 0:t.label,i.createElement("small",{className:"msp-25-lower-contrast-text",style:{float:"right"}},null===(r=n.obj)||void 0===r?void 0:r.description)),i.createElement(p.IconButton,{svg:n.state.isHidden?b.VisibilityOffOutlinedSvg:b.VisibilityOutlinedSvg,toggleState:!1,onClick:this.toggleVisible,title:(n.state.isHidden?"Show":"Hide")+" component",small:!0,className:"msp-form-control",flex:!0}),i.createElement(p.IconButton,{svg:b.DeleteOutlinedSvg,onClick:this.remove,title:"Remove",small:!0}),i.createElement(p.IconButton,{svg:b.MoreHorizSvg,onClick:this.toggleUpdate,title:"Actions",toggleState:"update"===this.state.action})),"update"===this.state.action&&!!n.parent&&i.createElement("div",{style:{marginBottom:"6px"},className:"msp-accent-offset"},i.createElement(h.UpdateTransformControl,{state:n.parent,transform:n.transform,customHeader:"none",noMargin:!0})))},t}(d.PurePluginUIComponent)},function(e,t,r){"use strict";r.d(t,"a",(function(){return h}));var n=r(0),i=r(13),a=r(8),o=r(177),s=r(146),u=r(27),c=r(2),l=r(5),d=r(158),f=r(247),p=r(116),m=r(78),h=function(e){function t(r){var s=e.call(this)||this;return s.plugin=r,s.data=i.State.create(new a.a.Root({}),{runTask:s.plugin.runTask,globalContext:s.plugin,historyCapacity:s.plugin.config.get(m.PluginConfig.State.HistoryCapacity)}),s.behaviors=i.State.create(new o.PluginBehavior.Root({}),{runTask:s.plugin.runTask,globalContext:s.plugin,rootState:{isLocked:!0}}),s.events={cell:{stateUpdated:Object(f.a)(s.data.events.cell.stateUpdated,s.behaviors.events.cell.stateUpdated),created:Object(f.a)(s.data.events.cell.created,s.behaviors.events.cell.created),removed:Object(f.a)(s.data.events.cell.removed,s.behaviors.events.cell.removed)},object:{created:Object(f.a)(s.data.events.object.created,s.behaviors.events.object.created),removed:Object(f.a)(s.data.events.object.removed,s.behaviors.events.object.removed),updated:Object(f.a)(s.data.events.object.updated,s.behaviors.events.object.updated)}},s.snapshotParams=s.ev.behavior(t.DefaultSnapshotParams),s.setSnapshotParams=function(e){s.snapshotParams.next(Object(n.__assign)(Object(n.__assign)({},t.DefaultSnapshotParams),e))},s}return Object(n.__extends)(t,e),Object.defineProperty(t.prototype,"animation",{get:function(){return this.plugin.managers.animation},enumerable:!1,configurable:!0}),t.prototype.getSnapshot=function(e){var t,r,i=Object(n.__assign)(Object(n.__assign)({},this.snapshotParams.value),e);return{id:l.c.create22(),data:i.data?this.data.getSnapshot():void 0,behaviour:i.behavior?this.behaviors.getSnapshot():void 0,animation:i.animation?this.animation.getSnapshot():void 0,startAnimation:i.startAnimation?!!i.startAnimation:void 0,camera:i.camera?{current:this.plugin.canvas3d.camera.getSnapshot(),transitionStyle:i.cameraTransition.name,transitionDurationInMs:"animate"===(null===(t=null==i?void 0:i.cameraTransition)||void 0===t?void 0:t.name)?i.cameraTransition.params.durationInMs:void 0}:void 0,canvas3d:i.canvas3d?{props:null===(r=this.plugin.canvas3d)||void 0===r?void 0:r.props}:void 0,interactivity:i.interactivity?{props:this.plugin.managers.interactivity.props}:void 0,structureFocus:this.plugin.managers.structure.focus.getSnapshot(),durationInMs:null==i?void 0:i.durationInMs}},t.prototype.setSnapshot=function(e){var t;return Object(n.__awaiter)(this,void 0,void 0,(function(){var r;return Object(n.__generator)(this,(function(n){switch(n.label){case 0:return[4,this.animation.stop()];case 1:return n.sent(),e.behaviour?[4,this.plugin.runTask(this.behaviors.setSnapshot(e.behaviour))]:[3,3];case 2:n.sent(),n.label=3;case 3:return e.data?[4,this.plugin.runTask(this.data.setSnapshot(e.data))]:[3,5];case 4:n.sent(),n.label=5;case 5:return(null===(t=e.canvas3d)||void 0===t?void 0:t.props)?(r=c.ParamDefinition.normalizeParams(s.Canvas3DParams,e.canvas3d.props,"children"),[4,u.PluginCommands.Canvas3D.SetSettings(this.plugin,{settings:r})]):[3,7];case 6:n.sent(),n.label=7;case 7:return e.interactivity&&e.interactivity.props&&this.plugin.managers.interactivity.setProps(e.interactivity.props),e.structureFocus&&this.plugin.managers.structure.focus.setSnapshot(e.structureFocus),e.animation&&this.animation.setSnapshot(e.animation),e.camera&&u.PluginCommands.Camera.Reset(this.plugin,{snapshot:e.camera.current,durationMs:"animate"===e.camera.transitionStyle?e.camera.transitionDurationInMs:void 0}),e.startAnimation&&this.animation.start(),[2]}}))}))},t.prototype.updateTransform=function(e,t,r,n){var i=e.build().to(t).update(r);return u.PluginCommands.State.Update(this.plugin,{state:e,tree:i,options:{canUndo:n}})},t.prototype.updateBehavior=function(e,t){var r=this.behaviors.build();if(this.behaviors.tree.transforms.has(e.id))r.to(e.id).update(t);else{var n=e.createDefaultParams(void 0,this.plugin);r.to(o.PluginBehavior.getCategoryId(e)).apply(e,Object(d.b)(n,t),{ref:e.id})}return this.plugin.runTask(this.behaviors.updateTree(r))},t.prototype.dispose=function(){this.behaviors.cells.forEach((function(e){o.PluginBehavior.Behavior.is(e.obj)&&e.obj.data.unregister()})),e.prototype.dispose.call(this),this.data.dispose(),this.behaviors.dispose(),this.animation.dispose()},t}(p.a);!function(e){e.SnapshotParams={durationInMs:c.ParamDefinition.Numeric(1500,{min:100,max:15e3,step:100},{label:"Duration in ms"}),data:c.ParamDefinition.Boolean(!0),behavior:c.ParamDefinition.Boolean(!1),animation:c.ParamDefinition.Boolean(!0),startAnimation:c.ParamDefinition.Boolean(!1),canvas3d:c.ParamDefinition.Boolean(!0),interactivity:c.ParamDefinition.Boolean(!0),camera:c.ParamDefinition.Boolean(!0),cameraTransition:c.ParamDefinition.MappedStatic("animate",{animate:c.ParamDefinition.Group({durationInMs:c.ParamDefinition.Numeric(250,{min:100,max:5e3,step:500},{label:"Duration in ms"})}),instant:c.ParamDefinition.Group({})},{options:[["animate","Animate"],["instant","Instant"]]})},e.DefaultSnapshotParams=c.ParamDefinition.getDefaultValues(e.SnapshotParams)}(h||(h={}))},function(e,t,r){"use strict";r.d(t,"a",(function(){return n}));var n=function(e){return e&&"number"==typeof e.length&&"function"!=typeof e}},function(e,t,r){"use strict";r.d(t,"a",(function(){return n}));var n=function(e){return function(t){for(var r=0,n=e.length;r<n&&!t.closed;r++)t.next(e[r]);t.complete()}}},function(e,t,r){"use strict";function n(e){return!!e&&"function"!=typeof e.subscribe&&"function"==typeof e.then}r.d(t,"a",(function(){return n}))},function(e,t,r){"use strict";r.r(t),r.d(t,"StateTree",(function(){return g}));var n=r(0),i=r(3),a=r(168),o=r(400),s=r(27),u=r(13),c=r(311),l=r(33),d=r(56),f=r(18),p=r(15),m=r(318),h=r(189),g=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={showActions:!0},t}return Object(n.__extends)(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.state.events.cell.created,(function(t){t.cell.transform.parent===u.StateTransform.RootRef&&e.forceUpdate()})),this.subscribe(this.plugin.state.events.cell.removed,(function(t){t.parent===u.StateTransform.RootRef&&e.forceUpdate()}))},t.getDerivedStateFromProps=function(e,t){var r=e.state.tree.root.ref,n=0===e.state.tree.children.get(r).size;return t.showActions===n?null:{showActions:n}},t.prototype.render=function(){var e=this.props.state.tree.root.ref;return this.state.showActions?i.createElement("div",{style:{margin:"10px",cursor:"default"}},i.createElement("p",null,"Nothing to see here yet."),i.createElement("p",null,"Structures and Volumes can be loaded from the ",i.createElement(p.Icon,{svg:p.HomeOutlinedSvg})," tab.")):i.createElement(v,{cell:this.props.state.cells.get(e),depth:0})},t}(l.PluginUIComponent),v=function(e){function t(){var r=null!==e&&e.apply(this,arguments)||this;return r.state={isCollapsed:!!r.props.cell.state.isCollapsed,isNull:t.isNull(r.props.cell),showLabel:t.showLabel(r.props.cell)},r}return Object(n.__extends)(t,e),t.prototype.is=function(e){return e.ref===this.ref&&e.state===this.props.cell.parent},Object.defineProperty(t.prototype,"ref",{get:function(){return this.props.cell.transform.ref},enumerable:!1,configurable:!0}),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.state.events.cell.stateUpdated,(function(r){e.props.cell===r.cell&&e.is(r)&&r.state.cells.has(e.ref)&&(e.state.isCollapsed===!!r.cell.state.isCollapsed&&e.state.isNull===t.isNull(r.cell)&&e.state.showLabel===t.showLabel(r.cell)||e.forceUpdate())})),this.subscribe(this.plugin.state.events.cell.created,(function(t){e.props.cell.parent===t.state&&e.ref===t.cell.transform.parent&&e.forceUpdate()})),this.subscribe(this.plugin.state.events.cell.removed,(function(t){e.props.cell.parent===t.state&&e.ref===t.parent&&e.forceUpdate()}))},t.getDerivedStateFromProps=function(e,r){var n=t.isNull(e.cell),i=t.showLabel(e.cell);return!!e.cell.state.isCollapsed===r.isCollapsed&&r.isNull===n&&r.showLabel===i?null:{isCollapsed:!!e.cell.state.isCollapsed,isNull:n,showLabel:i}},t.hasDecorator=function(e){var t,r=e.parent.tree.children.get(e.transform.ref);return 1===r.size&&!!(null===(t=e.parent)||void 0===t?void 0:t.tree.transforms.get(r.first()).transformer.definition.isDecorator)},t.isNull=function(e){return!e||!e.parent||e.obj===u.StateObject.Null||!e.parent.tree.transforms.has(e.transform.ref)},t.showLabel=function(e){return e.transform.ref!==u.StateTransform.RootRef&&("ok"!==e.status||!e.state.isGhost&&!t.hasDecorator(e))},t.prototype.render=function(){var e=this;if(this.state.isNull)return null;var r=this.props.cell,n=r.parent.tree.children.get(this.ref);if(!this.state.showLabel)return 0===n.size?null:i.createElement(i.Fragment,null,n.map((function(n){return i.createElement(t,{cell:r.parent.cells.get(n),key:n,depth:e.props.depth})})));var a=this.props.depth+1;return i.createElement(i.Fragment,null,i.createElement(b,{cell:r,depth:this.props.depth}),0===n.size?void 0:i.createElement("div",{style:{display:this.state.isCollapsed?"none":"block"}},n.map((function(e){return i.createElement(t,{cell:r.parent.cells.get(e),key:e,depth:a})}))))},t}(l.PluginUIComponent),b=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={isCurrent:t.props.cell.parent.current===t.ref,isCollapsed:!!t.props.cell.state.isCollapsed,action:void 0,currentAction:void 0},t.setCurrent=function(e){null==e||e.preventDefault(),null==e||e.currentTarget.blur(),s.PluginCommands.State.SetCurrentObject(t.plugin,{state:t.props.cell.parent,ref:t.ref})},t.setCurrentRoot=function(e){null==e||e.preventDefault(),null==e||e.currentTarget.blur(),s.PluginCommands.State.SetCurrentObject(t.plugin,{state:t.props.cell.parent,ref:u.StateTransform.RootRef})},t.remove=function(e){null==e||e.preventDefault(),s.PluginCommands.State.RemoveObject(t.plugin,{state:t.props.cell.parent,ref:t.ref,removeParentGhosts:!0})},t.toggleVisible=function(e){e.preventDefault(),s.PluginCommands.State.ToggleVisibility(t.plugin,{state:t.props.cell.parent,ref:t.ref}),e.currentTarget.blur()},t.toggleExpanded=function(e){e.preventDefault(),s.PluginCommands.State.ToggleExpanded(t.plugin,{state:t.props.cell.parent,ref:t.ref}),e.currentTarget.blur()},t.highlight=function(e){e.preventDefault(),s.PluginCommands.Interactivity.Object.Highlight(t.plugin,{state:t.props.cell.parent,ref:t.ref}),e.currentTarget.blur()},t.clearHighlight=function(e){e.preventDefault(),s.PluginCommands.Interactivity.ClearHighlights(t.plugin),e.currentTarget.blur()},t.hideApply=function(){t.setCurrentRoot()},t.selectAction=function(e){e&&(null==e?void 0:e.value)()},t}return Object(n.__extends)(t,e),t.prototype.is=function(e){return e.ref===this.ref&&e.state===this.props.cell.parent},Object.defineProperty(t.prototype,"ref",{get:function(){return this.props.cell.transform.ref},enumerable:!1,configurable:!0}),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.state.events.cell.stateUpdated.pipe(Object(a.a)((function(t){return e.is(t)})),Object(o.a)(33)),(function(t){e.forceUpdate()})),this.subscribe(this.props.cell.parent.behaviors.currentObject,(function(t){e.is(t)?t.state.transforms.has(e.ref)&&e._setCurrent(e.props.cell.parent.current===e.ref,!!e.props.cell.state.isCollapsed):e.state.isCurrent&&t.state.transforms.has(e.ref)&&e._setCurrent(e.props.cell.parent.current===e.ref,e.state.isCollapsed)}))},t.prototype._setCurrent=function(e,t){e?this.setState({isCurrent:e,action:"options",currentAction:void 0,isCollapsed:t}):this.setState({isCurrent:e,action:void 0,currentAction:void 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o=r[a];n.push(i.createElement(h.UpdateTransformControl,{key:o.transform.transformer.id+"-"+a,state:t.parent,transform:o.transform,noMargin:!0,wrapInExpander:!0,expanderHeaderLeftMargin:e}))}return i.createElement("div",{className:"msp-tree-updates-wrapper"},n)},t.prototype.render=function(){var e=this.props.cell,t=e.transform;if(!e)return null;var r,n=this.is(e.parent.behaviors.currentObject.value),a="error"!==e.status&&"ok"!==e.status;if("error"!==e.status&&e.obj){var o=e.obj,s=o.label+" "+(o.description?o.description:"");r=i.createElement(f.Button,{className:"msp-btn-tree-label msp-type-class-"+o.type.typeClass,noOverflow:!0,disabled:a,title:s,onClick:this.state.isCurrent?this.setCurrentRoot:this.setCurrent},i.createElement("span",null,o.label)," ",o.description?i.createElement("small",null,o.description):void 0)}else{var u="error"===e.status?e.errorText:t.transformer.definition.display.name;r=i.createElement(f.Button,{className:"msp-btn-tree-label 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r=t.resources,n=o.a.getGridToCartesianTransform(e.grid),i=A.Vec3.clone(e.grid.cells.space.dimensions),a=U(i,1),s=a.width,u=a.height,c=a.powerOfTwoSize,l=A.Vec3.create(s,u,0),d=A.Vec2.create(s/c,u/c);if(c>t.maxTextureSize/2)throw new Error("volume too large for gpu isosurface extraction");if(!e._propertyData[te]){e._propertyData[te]=r.texture("image-uint8","alpha","ubyte","linear");var f=e._propertyData[te];f.define(c,c),f.load(z(e,"data",1),!0),e.customProperties.add(ee.descriptor),e.customProperties.assets(ee.descriptor,[{dispose:function(){return f.destroy()}}])}return i[0]+=1,i[1]+=1,{texture:e._propertyData[te],transform:n,gridDimension:i,gridTexDim:l,gridTexScale:d}};var ae=Object(n.__assign)(Object(n.__assign)(Object(n.__assign)({},E.a.Params),W),{quality:Object(n.__assign)(Object(n.__assign)({},E.a.Params.quality),{isEssential:!1}),sizeFactor:a.ParamDefinition.Numeric(3,{min:0,max:10,step:.1})});function oe(e){return 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r=e.cells.space,n=he(e,t),i=n.width,a=n.height,o=n.x0,s=n.y0,u=n.z0,c=n.nx,l=n.ny,d=n.nz,f=new Uint8Array(i*a*4),p=0,m=s;m<l;++m)for(var h=o;h<c;++h)for(var g=u;g<d;++g)Object(M.b)(r.dataOffset(h,m,g),f,p),p+=4;return f}(t.grid,i),R=0,L=E;L<T;++L)for(N=j;N<D;++N)for(F=A;F<I;++F)U=c.get(l,N,L,F),z=(U-f)/(p-f),B[R]=v*z*2*255,B[R+1]=b*z*2*255,B[R+2]=y*z*2*255,B[R+3]=U>=m?255:0,R+=4;return H={width:S,height:x,array:B,flipY:!0},G={width:S,height:x,array:V,flipY:!0},q=o.a.getGridToCartesianTransform(t.grid),Object(fe.e)(q,k,0,4),[2,de.a.create(H,k,G,a)]}))}))}function he(e,t){var r,n,i,a,o,s=t.dimension,u=s.name,c=s.params,l=0,d=0,f=0,p=e.cells.space.dimensions,m=p[0],h=p[1],g=p[2];return"x"===u?(a=h-1,o=g-1,r=g,n=h,m=(l=i=c)+1):"y"===u?(i=m-1,o=g-1,r=g,n=m,h=(d=a=c)+1):(i=m-1,a=h-1,r=m,n=h,g=(f=o=c)+1),{width:r,height:n,x:i,y:a,z:o,x0:l,y0:d,z0:f,nx:m,ny:h,nz:g}}function ge(e,t){var r=function(e,t){for(var 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Object(j.a)(e.grid.cells.data.length,1,1,(function(){return P.b}))},getLoci:ve,eachLocation:be,setUpdateState:function(e,t,r,n,i,a){e.createGeometry=r.dimension.name!==n.dimension.name||r.dimension.params!==n.dimension.params||!o.b.IsoValue.areSame(r.isoValue,n.isoValue,t.grid.stats)||!v.a.areEqual(i.color,a.color)},geometryUtils:Object(n.__assign)(Object(n.__assign)({},de.a.Utils),{createRenderableState:function(e){var t=de.a.Utils.createRenderableState(e);return Se(t,e),t},updateRenderableState:Se})},e)}function Se(e,t){de.a.Utils.updateRenderableState(e,t),e.opaque=!1,e.writeDepth=!0}var xe={name:"slice",label:"Slice",description:"Slice of volume rendered as image with interpolation.",factory:function(e,t){return C("Slice",e,t,_e,ge)},getParams:function(e,t){var r=a.ParamDefinition.clone(ye),n=t.grid.cells.space.dimensions;return r.dimension=a.ParamDefinition.MappedStatic("x",{x:a.ParamDefinition.Numeric(0,{min:0,max:n[0]-1,step:1}),y:a.ParamDefinition.Numeric(0,{min:0,max:n[1]-1,step:1}),z:a.ParamDefinition.Numeric(0,{min:0,max:n[2]-1,step:1})},{isEssential:!0}),r.isoValue=o.b.createIsoValueParam(o.b.IsoValue.absolute(t.grid.stats.min),t.grid.stats),r},defaultValues:a.ParamDefinition.getDefaultValues(ye),defaultColorTheme:{name:"uniform"},defaultSizeTheme:{name:"uniform"},isApplicable:function(e){return!o.b.isEmpty(e)}},Oe=r(9),we=r(151);function Ce(e,t){var r=Object(Oe.b)();return Oe.b.add(r,e),Oe.b.transform(r,r,t),r}function je(e,t,r,n){var i=r.grid.cells.space.dimensions,a=U(i),s=a.width,u=a.height;if(Math.max(s,u)>t.maxTextureSize/2)throw new Error("volume too large for direct-volume rendering");var c=z(r,"normals"),l=o.a.getGridToCartesianTransform(r.grid),d=Ce(i,l),f=n?n.gridTexture.ref.value:t.resources.texture("image-uint8","rgba","ubyte","linear");f.load(c);var p=Pe(r.grid),m=p.unitToCartn,h=p.cellDim;return we.a.create(d,i,l,m,h,f,r.grid.stats,!1,n)}function Pe(e){if("matrix"===e.transform.kind)return{unitToCartn:A.Mat4.mul(Object(A.Mat4)(),e.transform.matrix,A.Mat4.fromScaling(Object(A.Mat4)(),e.cells.space.dimensions)),cellDim:A.Mat4.getScaling(Object(A.Vec3)(),e.transform.matrix)};var t=e.transform.fractionalBox,r=Oe.b.size(Object(A.Vec3)(),t);return{unitToCartn:A.Mat4.mul3(Object(A.Mat4)(),e.transform.cell.fromFractional,A.Mat4.fromTranslation(Object(A.Mat4)(),t.min),A.Mat4.fromScaling(Object(A.Mat4)(),r)),cellDim:A.Vec3.div(Object(A.Vec3)(),e.transform.cell.size,e.cells.space.dimensions)}}function Ee(e,t,r,n){var i=r.grid.cells.space.dimensions;if(Math.max.apply(Math,i)>t.max3dTextureSize/2)throw new Error("volume too large for direct-volume rendering");var a=function(e){for(var t=e.grid,r=t.cells,n=r.space,i=r.data,a=t.stats,o=a.max,s=a.min,u=n.dimensions,c=u[0],l=u[1],d=u[2],f=n.dataOffset,p=new 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De(e,t){return"isosurface"===t.renderMode.name?o.b.Isosurface.Loci(e,t.renderMode.params.isoValue):o.b.Loci(e)}function Te(e,t,r,n){var i=e.objectId,a=e.groupId;return n===i?o.b.Cell.Loci(t,h.Interval.ofSingleton(a)):m.EmptyLoci}function Ie(e,t,r,n){return F(e,t,"isosurface"===r.renderMode.name?r.renderMode.params.isoValue:void 0,n)}var Me=Object(n.__assign)(Object(n.__assign)({},we.a.Params),{quality:Object(n.__assign)(Object(n.__assign)({},we.a.Params.quality),{isEssential:!1})});function ke(e){return w({defaultProps:a.ParamDefinition.getDefaultValues(Me),createGeometry:Ae,createLocationIterator:function(e){return Object(j.a)(e.grid.cells.data.length,1,1,(function(){return P.b}))},getLoci:Te,eachLocation:Ie,setUpdateState:function(e,t,r,n){},geometryUtils:we.a.Utils,dispose:function(e){e.gridTexture.ref.value.destroy()}},e)}var Be={name:"direct-volume",label:"Direct Volume",description:"Direct rendering of volumetric data.",factory:function(e,t){return C("Direct 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tDepthVolumes;\nuniform vec2 uTexSize;\n\n#include common\n\nfloat getDepth(const in vec2 coords, sampler2D tDepth) {\n    #ifdef dPackedDepth\n        return unpackRGBAToDepth(texture2D(tDepth, coords));\n    #else\n        return texture2D(tDepth, coords).r;\n    #endif\n}\n\nvoid main() {\n    vec2 coords = gl_FragCoord.xy / uTexSize;\n    float depth = min(getDepth(coords, tDepthPrimitives), getDepth(coords, tDepthVolumes));\n    gl_FragColor = packDepthToRGBA(depth);\n}\n");var S=Object(n.__assign)(Object(n.__assign)({},a.b),{tColor:Object(o.i)("texture","rgba","ubyte","nearest"),uTexSize:Object(o.j)("v2")}),x=Object(u.g)("copy",f.a,"\nprecision highp float;\nprecision highp sampler2D;\n\nuniform sampler2D tColor;\nuniform vec2 uTexSize;\n\nvoid main() {\n    vec2 coords = gl_FragCoord.xy / uTexSize;\n    gl_FragColor = texture2D(tColor, coords);\n}\n");function O(e,t){var r=Object(n.__assign)(Object(n.__assign)({},a.c),{tColor:l.e.create(t),uTexSize:l.e.create(d.Vec2.create(t.getWidth(),t.getHeight()))}),i=Object(n.__assign)({},S),o=Object(c.a)(e,"triangles",x,i,r);return Object(s.a)(o,r)}var w=function(){function e(e,t,r,o){this.webgl=e;var u,f,p,m,h,g,S,x=e.extensions,w=e.resources;this.drawTarget=Object(i.a)(e.gl),this.colorTarget=e.createRenderTarget(t,r,!0,"uint8","linear"),this.packedDepth=!x.depthTexture,this.depthTarget=e.createRenderTarget(t,r),this.depthTexture=this.depthTarget.texture,this.depthTargetPrimitives=this.packedDepth?e.createRenderTarget(t,r):null,this.depthTargetVolumes=this.packedDepth?e.createRenderTarget(t,r):null,this.depthTexturePrimitives=this.depthTargetPrimitives?this.depthTargetPrimitives.texture:w.texture("image-depth","depth","ushort","nearest"),this.depthTextureVolumes=this.depthTargetVolumes?this.depthTargetVolumes.texture:w.texture("image-depth","depth","ushort","nearest"),this.packedDepth||(this.depthTexturePrimitives.define(t,r),this.depthTextureVolumes.define(t,r)),this.depthMerge=(u=e,f=this.depthTexturePrimitives,p=this.depthTextureVolumes,m=this.packedDepth,h=Object(n.__assign)(Object(n.__assign)({},a.c),{tDepthPrimitives:l.e.create(f),tDepthVolumes:l.e.create(p),uTexSize:l.e.create(d.Vec2.create(f.getWidth(),f.getHeight())),dPackedDepth:l.e.create(m)}),g=Object(n.__assign)({},y),S=Object(c.a)(u,"triangles",_,g,h),Object(s.a)(S,h)),this.wboit=o?new v(e,t,r):void 0,this.postprocessing=new b.c(e,this),this.antialiasing=new b.a(e,this),this.copyFboTarget=O(e,this.colorTarget.texture),this.copyFboPostprocessing=O(e,this.postprocessing.target.texture)}return Object.defineProperty(e.prototype,"wboitEnabled",{get:function(){var e;return!!(null===(e=this.wboit)||void 0===e?void 0:e.supported)},enumerable:!1,configurable:!0}),e.prototype.reset=function(){var e;null===(e=this.wboit)||void 0===e||e.reset()},e.prototype.setSize=function(e,t){var r,n=this.colorTarget.getWidth(),i=this.colorTarget.getHeight();e===n&&t===i||(this.colorTarget.setSize(e,t),this.depthTarget.setSize(e,t),this.depthTargetPrimitives?this.depthTargetPrimitives.setSize(e,t):this.depthTexturePrimitives.define(e,t),this.depthTargetVolumes?this.depthTargetVolumes.setSize(e,t):this.depthTextureVolumes.define(e,t),l.e.update(this.depthMerge.values.uTexSize,d.Vec2.set(this.depthMerge.values.uTexSize.ref.value,e,t)),l.e.update(this.copyFboTarget.values.uTexSize,d.Vec2.set(this.copyFboTarget.values.uTexSize.ref.value,e,t)),l.e.update(this.copyFboPostprocessing.values.uTexSize,d.Vec2.set(this.copyFboPostprocessing.values.uTexSize.ref.value,e,t)),(null===(r=this.wboit)||void 0===r?void 0:r.supported)&&this.wboit.setSize(e,t),this.postprocessing.setSize(e,t),this.antialiasing.setSize(e,t))},e.prototype._depthMerge=function(){var e=this.webgl,t=e.state,r=e.gl;this.depthMerge.update(),this.depthTarget.bind(),t.disable(r.BLEND),t.disable(r.DEPTH_TEST),t.disable(r.CULL_FACE),t.depthMask(!1),t.clearColor(1,1,1,1),r.clear(r.COLOR_BUFFER_BIT),this.depthMerge.render()},e.prototype._renderWboit=function(e,t,r,n,i){var a;if(!(null===(a=this.wboit)||void 0===a?void 0:a.supported))throw new Error("expected wboit to be supported");this.colorTarget.bind(),e.clear(!0),this.depthTexturePrimitives.attachFramebuffer(this.colorTarget.framebuffer,"depth"),this.colorTarget.bind(),e.clearDepth(),e.renderWboitOpaque(r.primitives,t,null),this.depthTextureVolumes.attachFramebuffer(this.colorTarget.framebuffer,"depth"),this.colorTarget.bind(),e.clearDepth(),e.renderWboitOpaque(r.volumes,t,this.depthTexturePrimitives),this._depthMerge(),b.c.isEnabled(i)&&this.postprocessing.render(t,!1,n,e.props.backgroundColor,i),this.wboit.bind(),e.renderWboitTransparent(r.primitives,t,this.depthTexture),e.renderWboitTransparent(r.volumes,t,this.depthTexture),b.c.isEnabled(i)?(this.depthTexturePrimitives.attachFramebuffer(this.postprocessing.target.framebuffer,"depth"),this.postprocessing.target.bind()):(this.depthTexturePrimitives.attachFramebuffer(this.colorTarget.framebuffer,"depth"),this.colorTarget.bind()),this.wboit.render()},e.prototype._renderBlended=function(e,t,r,n,i,a){if(n?this.drawTarget.bind():(this.colorTarget.bind(),this.packedDepth||this.depthTexturePrimitives.attachFramebuffer(this.colorTarget.framebuffer,"depth")),e.clear(!0),e.renderBlendedOpaque(r.primitives,t,null),!n){this.depthTargetPrimitives&&(this.depthTargetPrimitives.bind(),e.clear(!1),e.renderDepth(r.primitives,t,null),this.colorTarget.bind()),this.packedDepth||(this.depthTextureVolumes.attachFramebuffer(this.colorTarget.framebuffer,"depth"),e.clearDepth()),e.renderBlendedVolumeOpaque(r.volumes,t,this.depthTexturePrimitives),this.depthTargetVolumes&&(this.depthTargetVolumes.bind(),e.clear(!1),e.renderDepth(r.volumes,t,this.depthTexturePrimitives),this.colorTarget.bind()),this._depthMerge(),this.colorTarget.bind(),b.c.isEnabled(a)&&this.postprocessing.render(t,!1,i,e.props.backgroundColor,a),e.renderBlendedVolumeTransparent(r.volumes,t,this.depthTexturePrimitives);var o=b.c.isEnabled(a)?this.postprocessing.target:this.colorTarget;this.packedDepth||this.depthTexturePrimitives.attachFramebuffer(o.framebuffer,"depth"),o.bind()}e.renderBlendedTransparent(r.primitives,t,null)},e.prototype._render=function(e,t,r,n,i,a,o){var s=r.volumes.renderables.length>0,u=b.c.isEnabled(o),c=b.a.isEnabled(o),l=t.viewport,d=l.x,f=l.y,p=l.width,m=l.height;e.setViewport(d,f,p,m),e.update(t),this.wboitEnabled?this._renderWboit(e,t,r,a,o):this._renderBlended(e,t,r,!s&&!u&&!c&&i,a,o),b.c.isEnabled(o)?this.postprocessing.target.bind():!i||s||this.wboitEnabled?this.colorTarget.bind():this.drawTarget.bind(),n.debug.isEnabled&&(n.debug.syncVisibility(),e.renderBlended(n.debug.scene,t,null)),n.handle.isEnabled&&e.renderBlended(n.handle.scene,t,null),n.camera.isEnabled&&(n.camera.update(t),e.update(n.camera.camera),e.renderBlended(n.camera.scene,n.camera.camera,null)),c?this.antialiasing.render(t,i,o):i&&(this.drawTarget.bind(),this.webgl.state.disable(this.webgl.gl.DEPTH_TEST),b.c.isEnabled(o)?this.copyFboPostprocessing.render():(s||this.wboitEnabled)&&this.copyFboTarget.render()),this.webgl.gl.flush()},e.prototype.render=function(e,t,r,n,i,a,o){e.setTransparentBackground(a),e.setDrawingBufferSize(this.colorTarget.getWidth(),this.colorTarget.getHeight()),p.a.is(t)?(this._render(e,t.left,r,n,i,a,o),this._render(e,t.right,r,n,i,a,o)):this._render(e,t,r,n,i,a,o)},e.prototype.getColorTarget=function(e){return b.a.isEnabled(e)?this.antialiasing.target:b.c.isEnabled(e)?this.postprocessing.target:this.colorTarget},e}()},function(e,t,r){"use strict";r.d(t,"a",(function(){return _}));var n=r(0),i=r(224),a=r(116),o=r(8),s=r(13);function u(e,t){var r=function(e,t){return{state:e,oldHierarchy:t,hierarchy:c(),changed:!1,added:new Set}}(e,t||c());return function(e,t){var r={tree:e,state:t};v(r,e.root)}(e.tree,r),t&&t.refs.forEach(h,r),{hierarchy:r.hierarchy,added:r.added,changed:r.changed}}function c(){return{volumes:[],refs:new Map}}function l(e){return{kind:"volume",cell:e,version:e.transform.version,representations:[]}}function d(e,t){return{kind:"volume-representation",cell:e,version:e.transform.version,volume:t}}function f(e,t,r,n){for(var i=[],a=4;a<arguments.length;a++)i[a-4]=arguments[a];var o=n.apply(void 0,i);r.push(o),e.hierarchy.refs.set(t.transform.ref,o);var s=e.oldHierarchy.refs.get(t.transform.ref);return s?s.version!==t.transform.version&&(e.changed=!0):(e.added.add(o.cell.transform.ref),e.changed=!0),o}var p=[[function(e,t){return function(r,n){return!t(n)&&e.is(r.obj)}}(o.a.Volume.Data,(function(e){return e.currentVolume})),function(e,t){e.currentVolume=f(e,t,e.hierarchy.volumes,l,t)},function(e){return e.currentVolume=void 0}],[function(e,t){return!e.state.isGhost&&!!t.currentVolume&&o.a.Volume.Representation3D.is(e.obj)},function(e,t){return e.currentVolume&&f(e,t,e.currentVolume.representations,d,t,e.currentVolume),!1},function(){}]];function m(e){if(!e||!(null==e?void 0:e.parent)||!e.parent.cells.has(e.transform.ref))return!1;var t=e.obj;return!(!t||t===s.StateObject.Null||"ok"!==e.status&&"error"!==e.status)}function h(e){m(e.cell)||(this.changed=!0)}function g(e){v(this,this.tree.transforms.get(e))}function v(e,t){var r=e.state,n=r.state.cells.get(t.ref);if(m(n)){for(var i=void 0,a=!1,o=0,s=p;o<s.length;o++){var u=s[o],c=u[0],l=u[1],d=u[2];if(c(n,r)){if(!1===l(r,n)){a=!0;break}i=d;break}}if(!a){var f=e.tree.children.get(t.ref);f&&f.size&&f.forEach(g,e),i&&i(r)}}}var b=r(295),y=r(31),_=function(e){function t(t){var r=e.call(this)||this;return r.plugin=t,r.state={syncedTree:r.dataState.tree,notified:!1,hierarchy:c(),selection:void 0},r.behaviors={selection:r.ev.behavior({hierarchy:r.current,volume:r.selection})},r.subscribe(t.state.data.events.changed,(function(e){e.inTransaction||t.behaviors.state.isAnimating.value||r.sync(!0)})),r.subscribe(t.behaviors.state.isAnimating,(function(e){e||t.behaviors.state.isUpdating.value||r.sync(!0)})),r}return Object(n.__extends)(t,e),Object.defineProperty(t.prototype,"dataState",{get:function(){return this.plugin.state.data},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"current",{get:function(){return this.sync(!1),this.state.hierarchy},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"selection",{get:function(){return this.sync(!1),this.state.selection},enumerable:!1,configurable:!0}),t.prototype.sync=function(e){if(e||!this.dataState.inUpdate)if(this.state.syncedTree!==this.dataState.tree){this.state.syncedTree=this.dataState.tree;var t=u(this.plugin.state.data,this.current);if(t.changed){var r=t.hierarchy;this.state.hierarchy=r,this.state.selection?this.state.selection=r.refs.has(this.state.selection.cell.transform.ref)?r.refs.get(this.state.selection.cell.transform.ref):r.volumes[0]:this.state.selection=r.volumes[0],e?(this.state.notified=!0,this.behaviors.selection.next({hierarchy:r,volume:this.state.selection})):this.state.notified=!1}}else e&&!this.state.notified&&(this.state.notified=!0,this.behaviors.selection.next({hierarchy:this.state.hierarchy,volume:this.state.selection}))},t.prototype.setCurrent=function(e){this.state.selection=e||this.state.hierarchy.volumes[0],this.behaviors.selection.next({hierarchy:this.state.hierarchy,volume:e||this.state.hierarchy.volumes[0]})},t.prototype.remove=function(e,t){if(0!==e.length){for(var r=this.plugin.state.data.build(),n=0,i=e;n<i.length;n++){var a=i[n];r.delete("string"==typeof a?a:a.cell.transform.ref)}return r.commit({canUndo:!!t&&"Remove"})}},t.prototype.toggleVisibility=function(e,t){if(0!==e.length)for(var r=void 0!==t?"show"!==t:!e[0].cell.state.isHidden,n=0,a=e;n<a.length;n++){var o=a[n];Object(i.setSubtreeVisibility)(this.dataState,o.cell.transform.ref,r)}},t.prototype.addRepresentation=function(e,t){var r;return this.dataState.build().to(e.cell).apply(y.StateTransforms.Representation.VolumeRepresentation3D,Object(b.a)(this.plugin,null===(r=e.cell.obj)||void 0===r?void 0:r.data,{type:t})).commit({canUndo:"Add Representation"})},t}(a.a);(_||(_={})).getRepresentationTypes=function(e,t){var r,n;return(null===(r=null==t?void 0:t.cell.obj)||void 0===r?void 0:r.data)?e.representation.volume.registry.getApplicableTypes(null===(n=t.cell.obj)||void 0===n?void 0:n.data):e.representation.volume.registry.types}},function(e,t,r){"use strict";r.d(t,"b",(function(){return c})),r.d(t,"a",(function(){return l}));var n=r(0),i=r(2);function a(e,t,r,n,i,a,s){for(var u=0;u<t;u++){for(var c=0;c<r;c++)n[c]=e[c*t+u];o(n,i,a,s,r);for(c=0;c<r;c++)e[c*t+u]=i[c]}for(c=0;c<r;c++){for(u=0;u<t;u++)n[u]=e[c*t+u];o(n,i,a,s,t);for(u=0;u<t;u++)e[c*t+u]=Math.sqrt(i[u])}}function o(e,t,r,n,i){r[0]=0,n[0]=Number.MIN_SAFE_INTEGER,n[1]=Number.MAX_SAFE_INTEGER;for(var a=1,o=0;a<i;a++){for(var s=(e[a]+a*a-(e[r[o]]+r[o]*r[o]))/(2*a-2*r[o]);s<=n[o];)o--,s=(e[a]+a*a-(e[r[o]]+r[o]*r[o]))/(2*a-2*r[o]);r[++o]=a,n[o]=s,n[o+1]=Number.MAX_SAFE_INTEGER}for(a=0,o=0;a<i;a++){for(;n[o+1]<a;)o++;t[a]=(a-r[o])*(a-r[o])+e[r[o]]}}var s=r(52),u={};function c(e){var t=JSON.stringify(e);return void 0===u[t]&&(u[t]=new d(e)),u[t]}var l={fontFamily:i.ParamDefinition.Select("sans-serif",[["sans-serif","Sans Serif"],["monospace","Monospace"],["serif","Serif"],["cursive","Cursive"]]),fontQuality:i.ParamDefinition.Select(3,[[0,"lower"],[1,"low"],[2,"medium"],[3,"high"],[4,"higher"]]),fontStyle:i.ParamDefinition.Select("normal",[["normal","Normal"],["italic","Italic"],["oblique","Oblique"]]),fontVariant:i.ParamDefinition.Select("normal",[["normal","Normal"],["small-caps","Small Caps"]]),fontWeight:i.ParamDefinition.Select("normal",[["normal","Normal"],["bold","Bold"]])},d=function(){function e(e){void 0===e&&(e={}),this.mapped={},this.scratchW=0,this.scratchH=0,this.currentX=0,this.currentY=0,this.cutoff=.5;var t=Object(n.__assign)(Object(n.__assign)({},i.ParamDefinition.getDefaultValues(l)),e);this.props=t;var r=32*(t.fontQuality+1);this.buffer=r/8,this.radius=r/3,this.lineHeight=Math.round(r+2*this.buffer+this.radius),this.maxWidth=Math.round(.75*this.lineHeight),this.texture=Object(s.c)(350*this.lineHeight*this.maxWidth,1,Uint8Array),this.scratchCanvas=document.createElement("canvas"),this.scratchCanvas.width=this.maxWidth,this.scratchCanvas.height=this.lineHeight,this.scratchContext=this.scratchCanvas.getContext("2d"),this.scratchContext.font=t.fontStyle+" "+t.fontVariant+" "+t.fontWeight+" "+r+"px "+t.fontFamily,this.scratchContext.fillStyle="black",this.scratchContext.textBaseline="middle",this.scratchData=new Uint8Array(this.lineHeight*this.maxWidth),this.gridOuter=new Float64Array(this.lineHeight*this.maxWidth),this.gridInner=new Float64Array(this.lineHeight*this.maxWidth),this.f=new Float64Array(Math.max(this.lineHeight,this.maxWidth)),this.d=new Float64Array(Math.max(this.lineHeight,this.maxWidth)),this.z=new Float64Array(Math.max(this.lineHeight,this.maxWidth)+1),this.v=new Int16Array(Math.max(this.lineHeight,this.maxWidth)),this.middle=Math.ceil(this.lineHeight/2),this.placeholder=this.get(String.fromCharCode(65533))}return e.prototype.get=function(e){if(void 0===this.mapped[e]){this.draw(e);var t=this.texture,r=t.array,n=t.width,i=t.height,a=this.scratchData;if(this.currentX+this.scratchW>n&&(this.currentX=0,this.currentY+=this.scratchH),this.currentY+this.scratchH>i)return console.warn("canvas to small"),this.placeholder;this.mapped[e]={x:this.currentX,y:this.currentY,w:this.scratchW,h:this.scratchH,nw:this.scratchW/this.lineHeight,nh:this.scratchH/this.lineHeight};for(var o=0;o<this.scratchH;++o)for(var s=0;s<this.scratchW;++s)r[n*(this.currentY+o)+this.currentX+s]=a[o*this.scratchW+s];this.currentX+=this.scratchW}return this.mapped[e]},e.prototype.draw=function(e){var t=this.lineHeight,r=this.scratchContext,n=this.scratchData,i=r.measureText(e),o=Math.min(this.maxWidth,Math.ceil(i.width+2*this.buffer)),s=o*t;r.clearRect(0,0,o,t),r.fillText(e,this.buffer,this.middle);for(var u=r.getImageData(0,0,o,t),c=0;c<s;c++){var l=u.data[4*c+3]/255;this.gridOuter[c]=1===l?0:0===l?Number.MAX_SAFE_INTEGER:Math.pow(Math.max(0,.5-l),2),this.gridInner[c]=1===l?Number.MAX_SAFE_INTEGER:0===l?0:Math.pow(Math.max(0,l-.5),2)}a(this.gridOuter,o,t,this.f,this.d,this.v,this.z),a(this.gridInner,o,t,this.f,this.d,this.v,this.z);for(c=0;c<s;c++){var d=this.gridOuter[c]-this.gridInner[c];n[c]=Math.max(0,Math.min(255,Math.round(255-255*(d/this.radius+this.cutoff))))}this.scratchW=o,this.scratchH=t},e}()},function(e,t,r){"use strict";r.d(t,"b",(function(){return y})),r.d(t,"a",(function(){return _}));var n=r(64);function i(e,t){switch(t){case"b":case"b[]":return e.BOOL;case"f":case"f[]":return e.FLOAT;case"i":case"i[]":return e.INT;case"v2":case"v2[]":return e.FLOAT_VEC2;case"v3":case"v3[]":return e.FLOAT_VEC3;case"v4":case"v4[]":return e.FLOAT_VEC4;case"m3":case"m3[]":return e.FLOAT_MAT3;case"m4":case"m4[]":return e.FLOAT_MAT4;default:console.error("unknown uniform kind '"+t+"'")}}function a(e,t,r){e.uniform1f(t,r)}function o(e,t,r){e.uniform1fv(t,r)}function s(e,t,r){e.uniform1i(t,r)}function u(e,t,r){e.uniform1iv(t,r)}function c(e,t,r){e.uniform2fv(t,r)}function l(e,t,r){e.uniform3fv(t,r)}function d(e,t,r){e.uniform4fv(t,r)}function f(e,t,r){e.uniformMatrix3fv(t,!1,r)}function p(e,t,r){e.uniformMatrix4fv(t,!1,r)}function m(e){switch(e){case"f":return a;case"f[]":return o;case"i":case"t":case"b":return s;case"i[]":case"t[]":case"b[]":return u;case"v2":case"v2[]":return c;case"v3":case"v3[]":return l;case"v4":case"v4[]":return d;case"m3":case"m3[]":return f;case"m4":case"m4[]":return p}}var h=r(288),g=r(99),v=r(48),b=Object(g.a)();function y(e){var t=e.createProgram();if(null===t)throw new Error("Could not create WebGL program");return t}function _(e,t,r,a,o){var s,u,c=o.defineValues,l=o.shaderCode,d=o.schema,f=y(e),p=b(),g=Object(n.j)(e,r,c,l),_=a("vert",g.vert),S=a("frag",g.frag);function x(){_.attach(f),S.attach(f),e.linkProgram(f),v.a&&function(e,t){if(!e.getProgramParameter(t,e.LINK_STATUS))throw new Error("Could not compile WebGL program. \n\n"+e.getProgramInfoLog(t))}(e,f),s=function(e,t,r){var n={};return Object.keys(r).forEach((function(i){var a=r[i];if("attribute"===a.type){var o=e.getAttribLocation(t,i);n[i]=o}else if("uniform"===a.type||"texture"===a.type){o=e.getUniformLocation(t,i);n[i]=o}})),n}(e,f,d),u=function(e){var t={};return Object.keys(e).forEach((function(r){var n=e[r];"uniform"===n.type?t[r]=m(n.kind):"texture"===n.type&&(t[r]=m("t"))})),t}(d),v.a&&(function(e,t,r){for(var n=e.getProgramParameter(t,e.ACTIVE_ATTRIBUTES),i=0;i<n;++i){var 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Object(n.__extends)(t,e),t.prototype.register=function(){this.ctx.customModelProperties.register(this.provider,this.params.autoAttach),this.ctx.managers.lociLabels.addProvider(this.labelPDBeValidation),this.ctx.representation.structure.themes.colorThemeRegistry.add(o.StructureQualityReportColorThemeProvider)},t.prototype.update=function(e){var t=this.params.autoAttach!==e.autoAttach;return 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n=r(0),i=r(24),a=r(4),o=r(2),s=r(149),u=r(46),c=r(241),l=r(257),d=Object(i.ColorMap)({H:16777215,D:16777152,T:16777120,HE:14286847,LI:13402367,BE:12779264,B:16758197,C:9474192,N:3166456,O:16715021,F:9494608,NE:11789301,NA:11230450,MG:9109248,AL:12560038,SI:1578e4,P:16744448,S:16777008,CL:2093087,AR:8442339,K:9388244,CA:4062976,SC:15132390,TI:12567239,V:10921643,CR:9083335,MN:10255047,FE:14706227,CO:15765664,NI:5296208,CU:13140019,ZN:8224944,GA:12750735,GE:6721423,AS:12419299,SE:16752896,BR:10889513,KR:6076625,RB:7351984,SR:65280,Y:9764863,ZR:9756896,NB:7586505,MO:5551541,TC:3907230,RU:2396047,RH:687500,PD:27013,AG:12632256,CD:16767375,IN:10909043,SN:6717568,SB:10380213,TE:13924864,I:9699476,XE:9699476,CS:5707663,BA:51456,LA:7394559,CE:16777159,PR:14286791,ND:13107143,PM:10747847,SM:9437127,EU:6422471,GD:4587463,TB:3211207,DY:2097095,HO:65436,ER:58997,TM:54354,YB:48952,LU:43812,HF:5096191,TA:5089023,W:2200790,RE:2522539,OS:2516630,IR:1528967,PT:13684960,AU:16765219,HG:12105936,TL:10900557,PB:5724513,BI:10375093,PO:11230208,AT:7688005,RN:4358806,FR:4325478,RA:32e3,AC:7384058,TH:47871,PA:41471,U:36863,NP:33023,PU:27647,AM:5528818,CM:7888099,BK:9064419,CF:10565332,ES:11739092,FM:11739066,MD:11734438,NO:12389767,LR:13041766,RF:13369433,DB:13697103,SG:14221381,BH:14680120,HS:15073326,MT:15400998,DS:16777215,RG:16777215,CN:16777215,UUT:16777215,FL:16777215,UUP:16777215,LV:16777215,UUH:16777215}),f=Object(i.Color)(16777215),p={carbonColor:o.ParamDefinition.MappedStatic("chain-id",{"chain-id":o.ParamDefinition.Group(Object(n.__assign)({},c.b)),"operator-name":o.ParamDefinition.Group(Object(n.__assign)({},l.b)),"element-symbol":o.ParamDefinition.Group({})},{description:"Use chain-id coloring for carbon atoms."}),saturation:o.ParamDefinition.Numeric(0,{min:-6,max:6,step:.1}),lightness:o.ParamDefinition.Numeric(.2,{min:-6,max:6,step:.1})};function m(e){return p}function h(e,t){var r=e[t];return void 0===r?f:r}function g(e,t){var r=Object(u.getAdjustedColorMap)(d,t.saturation,t.lightness),n="chain-id"===t.carbonColor.name?Object(c.a)(e,t.carbonColor.params).color:"operator-name"===t.carbonColor.name?Object(l.a)(e,t.carbonColor.params).color:void 0;function i(e,t){return n&&"C"===e?n(t,!1):h(r,e)}return{factory:g,granularity:"element-symbol"===t.carbonColor.name?"group":"groupInstance",color:function(e){if(a.StructureElement.Location.is(e)){if(a.Unit.isAtomic(e.unit))return i(e.unit.model.atomicHierarchy.atoms.type_symbol.value(e.element),e)}else if(a.Bond.isLocation(e)){if(a.Unit.isAtomic(e.aUnit))return i(e.aUnit.model.atomicHierarchy.atoms.type_symbol.value(e.aUnit.elements[e.aIndex]),e)}return f},props:t,description:"Assigns a color to every atom 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i.createElement(i.Fragment,null,i.createElement(b,null),i.createElement(v,null))},t}(c.CollapsableControls),v=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return Object(n.__extends)(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.managers.structure.measurement.behaviors.state,(function(){e.forceUpdate()}))},t.prototype.renderGroup=function(e,t){for(var r=[],n=0,a=e;n<a.length;n++){var o=a[n];o.obj&&r.push(i.createElement(_,{key:o.obj.id,cell:o}))}return r.length?i.createElement(d.ExpandGroup,{header:t,initiallyExpanded:!0},r):null},t.prototype.render=function(){var e=this.plugin.managers.structure.measurement.state;return i.createElement("div",{style:{marginTop:"6px"}},this.renderGroup(e.labels,"Labels"),this.renderGroup(e.distances,"Distances"),this.renderGroup(e.angles,"Angles"),this.renderGroup(e.dihedrals,"Dihedrals"))},t}(c.PurePluginUIComponent),b=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={isBusy:!1,action:void 0},t.measureDistance=function(){var e=t.plugin.managers.structure.selection.additionsHistory;t.plugin.managers.structure.measurement.addDistance(e[0].loci,e[1].loci)},t.measureAngle=function(){var e=t.plugin.managers.structure.selection.additionsHistory;t.plugin.managers.structure.measurement.addAngle(e[0].loci,e[1].loci,e[2].loci)},t.measureDihedral=function(){var e=t.plugin.managers.structure.selection.additionsHistory;t.plugin.managers.structure.measurement.addDihedral(e[0].loci,e[1].loci,e[2].loci,e[3].loci)},t.addLabel=function(){var e=t.plugin.managers.structure.selection.additionsHistory;t.plugin.managers.structure.measurement.addLabel(e[0].loci)},t.selectAction=function(e){t.toggleAdd(),e&&(null==e?void 0:e.value)()},t.toggleAdd=function(){return t.setState({action:"add"===t.state.action?void 0:"add"})},t.toggleOptions=function(){return t.setState({action:"options"===t.state.action?void 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(4 selections required)":" (top 4 selections)"),value:this.measureDihedral,disabled:e.length<4}]},enumerable:!1,configurable:!0}),t.prototype.highlight=function(e){this.plugin.managers.interactivity.lociHighlights.highlightOnly({loci:e},!1)},t.prototype.moveHistory=function(e,t){this.plugin.managers.structure.selection.modifyHistory(e,t,4)},t.prototype.focusLoci=function(e){this.plugin.managers.camera.focusLoci(e)},t.prototype.historyEntry=function(e,t){var r=this,n=this.plugin.managers.structure.selection.additionsHistory;return i.createElement("div",{className:"msp-flex-row",key:e.id},i.createElement(d.Button,{noOverflow:!0,title:"Click to focus. Hover to highlight.",onClick:function(){return r.focusLoci(e.loci)},style:{width:"auto",textAlign:"left"},onMouseEnter:function(){return r.highlight(e.loci)},onMouseLeave:this.plugin.managers.interactivity.lociHighlights.clearHighlights},t,". 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i.createElement(i.Fragment,null,i.createElement(l.a,{items:this.actions,onSelect:this.selectAction}),t.length>0&&i.createElement("div",{className:"msp-control-offset"},t),0===t.length&&i.createElement("div",{className:"msp-control-offset msp-help-text"},i.createElement("div",{className:"msp-help-description"},i.createElement(f.Icon,{svg:f.HelpOutlineSvg,inline:!0}),"Add one or more selections (toggle ",i.createElement(h.ToggleSelectionModeButton,{inline:!0})," mode)")))},t.prototype.render=function(){return i.createElement(i.Fragment,null,i.createElement("div",{className:"msp-flex-row"},i.createElement(d.ToggleButton,{icon:f.AddSvg,label:"Add",toggle:this.toggleAdd,isSelected:"add"===this.state.action,disabled:this.state.isBusy,className:"msp-btn-apply-simple"}),i.createElement(d.ToggleButton,{icon:f.TuneSvg,label:"",title:"Options",toggle:this.toggleOptions,isSelected:"options"===this.state.action,disabled:this.state.isBusy,style:{flex:"0 0 40px",padding:0}})),"add"===this.state.action&&this.add(),"options"===this.state.action&&i.createElement(y,null))},t}(c.PurePluginUIComponent),y=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={isDisabled:!1},t.changed=function(e){t.plugin.managers.structure.measurement.setOptions(e)},t}return Object(n.__extends)(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.managers.structure.measurement.behaviors.state,(function(){e.forceUpdate()})),this.subscribe(this.plugin.behaviors.state.isBusy,(function(t){e.setState({isDisabled:t})}))},t.prototype.render=function(){var e=this.plugin.managers.structure.measurement.state;return i.createElement("div",{className:"msp-control-offset"},i.createElement(p.ParameterControls,{params:o.b,values:e.options,onChangeValues:this.changed,isDisabled:this.state.isDisabled}))},t}(c.PurePluginUIComponent),_=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={showUpdate:!1},t.delete=function(){s.PluginCommands.State.RemoveObject(t.plugin,{state:t.props.cell.parent,ref:t.props.cell.transform.parent,removeParentGhosts:!0})},t.toggleVisibility=function(e){e.preventDefault(),s.PluginCommands.State.ToggleVisibility(t.plugin,{state:t.props.cell.parent,ref:t.props.cell.transform.parent}),e.currentTarget.blur()},t.highlight=function(){var e,r=t.selections;if(r){t.plugin.managers.interactivity.lociHighlights.clearHighlights();for(var n=0,i=r.data;n<i.length;n++){var a=i[n];t.plugin.managers.interactivity.lociHighlights.highlight({loci:a.loci},!1)}t.plugin.managers.interactivity.lociHighlights.highlight({loci:null===(e=t.props.cell.obj)||void 0===e?void 0:e.data.repr.getLoci()},!1)}},t.clearHighlight=function(){t.plugin.managers.interactivity.lociHighlights.clearHighlights()},t.toggleUpdate=function(){return t.setState({showUpdate:!t.state.showUpdate})},t.focus=function(){var e=t.selections;if(e){var r=a.Loci.getBundleBoundingSphere(S(e.data));r&&t.plugin.managers.camera.focusSphere(r)}},t.selectAction=function(e){e&&(t.setState({showUpdate:!1}),(null==e?void 0:e.value)())},t}return Object(n.__extends)(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.state.events.cell.stateUpdated,(function(t){e.forceUpdate()}))},Object.defineProperty(t.prototype,"selections",{get:function(){var e;return null===(e=this.props.cell.obj)||void 0===e?void 0:e.data.source},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"label",{get:function(){var e=this.selections;switch(null==e?void 0:e.data.length){case 1:return Object(u.lociLabel)(e.data[0].loci,{condensed:!0});case 2:return Object(u.distanceLabel)(S(e.data),{condensed:!0,unitLabel:this.plugin.managers.structure.measurement.state.options.distanceUnitLabel});case 3:return Object(u.angleLabel)(S(e.data),{condensed:!0});case 4:return Object(u.dihedralLabel)(S(e.data),{condensed:!0});default:return""}},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"actions",{get:function(){var e=this;return this.props.cell.sourceRef,[l.a.Item("Select This",(function(){return e.plugin.managers.structure.selection.fromSelections(e.props.cell.sourceRef)}),{icon:f.SetSvg})]},enumerable:!1,configurable:!0}),t.prototype.render=function(){var e=this.props.cell,t=e.obj;return t?i.createElement(i.Fragment,null,i.createElement("div",{className:"msp-flex-row",key:t.id,onMouseEnter:this.highlight,onMouseLeave:this.clearHighlight},i.createElement("button",{className:"msp-form-control msp-control-button-label msp-no-overflow",title:"Click to focus. Hover to highlight.",onClick:this.focus,style:{width:"auto",textAlign:"left"}},i.createElement("span",{dangerouslySetInnerHTML:{__html:this.label}})),i.createElement(d.IconButton,{svg:e.state.isHidden?f.VisibilityOffOutlinedSvg:f.VisibilityOutlinedSvg,toggleState:!1,small:!0,className:"msp-form-control",onClick:this.toggleVisibility,flex:!0,title:e.state.isHidden?"Show":"Hide"}),i.createElement(d.IconButton,{svg:f.DeleteOutlinedSvg,small:!0,className:"msp-form-control",onClick:this.delete,flex:!0,title:"Delete",toggleState:!1}),i.createElement(d.IconButton,{svg:f.MoreHorizSvg,className:"msp-form-control",onClick:this.toggleUpdate,flex:!0,title:"Actions",toggleState:this.state.showUpdate})),this.state.showUpdate&&e.parent&&i.createElement(i.Fragment,null,i.createElement("div",{className:"msp-accent-offset"},i.createElement(l.a,{items:this.actions,onSelect:this.selectAction,noOffset:!0}),i.createElement(d.ExpandGroup,{header:"Options",noOffset:!0},i.createElement(m.UpdateTransformControl,{state:e.parent,transform:e.transform,customHeader:"none",autoHideApply:!0}))))):null},t}(c.PurePluginUIComponent);function S(e){return{loci:e.map((function(e){return e.loci}))}}},function(e,t,r){"use strict";r.r(t),r.d(t,"StateObjectActions",(function(){return u}));var n=r(0),i=r(3),a=r(33),o=r(15),s=r(318),u=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return Object(n.__extends)(t,e),Object.defineProperty(t.prototype,"current",{get:function(){return this.props.state.behaviors.currentObject.value},enumerable:!1,configurable:!0}),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.state.events.object.updated,(function(t){var r=t.ref,n=t.state,i=e.current;i.ref===r&&i.state===n&&e.forceUpdate()})),this.subscribe(this.plugin.state.data.actions.events.added,(function(){return e.forceUpdate()})),this.subscribe(this.plugin.state.data.actions.events.removed,(function(){return e.forceUpdate()}))},t.prototype.render=function(){var e=this,t=this.props,r=t.state,n=t.nodeRef,a=r.cells.get(n),u=r.actions.fromCell(a,this.plugin);if(0===u.length)return null;var c=a.transform.transformer.definition,l=a.obj?a.obj.label:c.display&&c.display.name||c.name;return i.createElement("div",{className:"msp-state-actions"},!this.props.hideHeader&&i.createElement("div",{className:"msp-section-header"},i.createElement(o.Icon,{svg:o.CodeSvg})," ","Actions ("+l+")"),u.map((function(t,a){return i.createElement(s.a,{key:""+t.id,state:r,action:t,nodeRef:n,initiallyCollapsed:0===a?!e.props.alwaysExpandFirst&&e.props.initiallyCollapsed:e.props.initiallyCollapsed})})))},t}(a.PluginUIComponent)},function(e,t,r){"use strict";r.d(t,"a",(function(){return o}));var n=r(20),i=r(34),a=r(103);function o(e,t){return void 0===t&&(t=a.a),function(r){return r.lift(new s(e,t))}}var s=function(){function e(e,t){this.dueTime=e,this.scheduler=t}return e.prototype.call=function(e,t){return t.subscribe(new u(e,this.dueTime,this.scheduler))},e}(),u=function(e){function t(t,r,n){var i=e.call(this,t)||this;return 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Object(n.__extends)(t,e),t.prototype.render=function(){var e=this,t=this.props.entry,r="string"==typeof t.message?i.createElement("div",{dangerouslySetInnerHTML:{__html:t.message}}):i.createElement("div",null,i.createElement(t.message,null));return i.createElement("div",{className:"msp-toast-entry"},i.createElement("div",{className:"msp-toast-title",onClick:function(){return e.hide()}},t.title),i.createElement("div",{className:"msp-toast-message"},r),i.createElement("div",{className:"msp-toast-clear"}),i.createElement("div",{className:"msp-toast-hide"},i.createElement(o.IconButton,{svg:s.CancelSvg,onClick:this.hide,title:"Hide",className:"msp-no-hover-outline"})))},t}(a.PluginUIComponent),c=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return Object(n.__extends)(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.managers.toast.events.changed,(function(){return e.forceUpdate()}))},t.prototype.render=function(){var e=this.plugin.managers.toast.state;if(!e.entries.count())return null;var t=[];return e.entries.forEach((function(e,r){return t.push(e)})),t.sort((function(e,t){return e.serialNumber-t.serialNumber})),i.createElement("div",{className:"msp-toast-container"},t.map((function(e){return i.createElement(u,{key:e.serialNumber,entry:e})})))},t}(a.PluginUIComponent)},function(e,t,r){"use strict";r.r(t),r.d(t,"StructureSourceControls",(function(){return O}));var n=r(0),i=r(3),a=r(31),o=r(33),s=r(56),u=r(18),c=r(73),l=r(6),d=r(4),f=r(234),p=r(77),m=r(61),h=r(154),g=r(15);function v(e,t,r,n){for(var i=l.SortedArray.indexOf(t.unit.elements,t.element),a=d.StructureElement.Loci(t.structure,[{unit:t.unit,indices:l.OrderedSet.ofSingleton(i)}]),o="residue"===n?d.StructureElement.Loci.extendToWholeResidues(a):d.StructureElement.Loci.extendToWholeChains(a),s=d.StructureProperties.entity.pdbx_description(t).join(", "),u=0,c=r.units;u<c.length;u++){var f=c[u],m=d.StructureElement.Loci(o.structure,[{unit:f,indices:o.elements[0].indices}]),h=Object(p.lociLabel)(m,{reverse:!0,hidePrefix:!0,htmlStyling:!1,granularity:n});h||(h=Object(p.lociLabel)(m,{hidePrefix:!1,htmlStyling:!1})),r.units.length>1&&(h+=" | "+m.elements[0].unit.conformation.operator.name);var g={label:h,category:s,loci:m};e.has(s)?e.get(s).push(g):e.set(s,[g])}}function b(e){for(var t=new Map,r=d.StructureElement.Location.create(e),n=0,i=e.unitSymmetryGroups;n<i.length;n++){var a=i[n];if(d.Unit.isAtomic(a.units[0])){r.unit=a.units[0],r.element=a.elements[0];var o=d.Unit.Traits.is(r.unit.traits,1),s=d.StructureProperties.entity.type(r),u="non-polymer"===s,c="branched"===s;if(!!d.StructureProperties.entity.prd_id(r))v(t,r,a,"chain");else if(u&&!o)v(t,r,a,"residue");else if(c||u&&o)for(var l=r.unit,f=l.model.atomicHierarchy.residueAtomSegments.index,p=-1,m=0,h=l.elements.length;m<h;++m){var g=l.elements[m],b=f[g];b!==p&&(r.element=g,v(t,r,a,"residue"),p=b)}}}var y=[];return t.forEach((function(e,t){1===e.length?y.push({label:t+": "+e[0].label,loci:e[0].loci}):e.length<2e3&&y.push.apply(y,e)})),y}var y=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={isBusy:!1,showAction:!1},t.getSelectionItems=Object(h.b)((function(e){for(var t,r=[],i=0,a=e;i<a.length;i++){var o=null===(t=a[i].cell.obj)||void 0===t?void 0:t.data;if(o){var u=b(o);u.length>0&&r.push(Object(n.__spreadArrays)([s.a.Header(o.label,{description:o.label})],s.a.createItems(u,{label:function(e){return e.label},category:function(e){return e.category},description:function(e){return e.label}})))}}return r})),t.selectAction=function(e,r){if(e&&t.state.showAction){var n=e.value;(null==r?void 0:r.shiftKey)?t.plugin.managers.structure.focus.addFromLoci(n.loci):t.plugin.managers.structure.focus.set(n),t.focusCamera()}else t.setState({showAction:!1})},t.toggleAction=function(){return t.setState({showAction:!t.state.showAction})},t.focusCamera=function(){var e=t.plugin.managers.structure.focus.current;e&&t.plugin.managers.camera.focusLoci(e.loci)},t.clear=function(){t.plugin.managers.structure.focus.clear(),t.plugin.managers.camera.reset()},t.highlightCurrent=function(){var e=t.plugin.managers.structure.focus.current;e&&t.plugin.managers.interactivity.lociHighlights.highlightOnly({loci:e.loci},!1)},t.clearHighlights=function(){t.plugin.managers.interactivity.lociHighlights.clearHighlights()},t}return Object(n.__extends)(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.managers.structure.focus.behaviors.current,(function(t){e.getSelectionItems([]),e.forceUpdate()})),this.subscribe(this.plugin.managers.structure.focus.events.historyUpdated,(function(t){e.forceUpdate()})),this.subscribe(this.plugin.behaviors.state.isBusy,(function(t){e.setState({isBusy:t,showAction:!1})}))},Object.defineProperty(t.prototype,"isDisabled",{get:function(){return this.state.isBusy||0===this.actionItems.length},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"actionItems",{get:function(){var e=[],t=this.plugin.managers.structure.focus.history;t.length>0&&e.push(Object(n.__spreadArrays)([s.a.Header("History",{description:"Previously focused on items."})],s.a.createItems(t,{label:function(e){return e.label},description:function(e){return e.category&&e.label!==e.category?e.category+" | "+e.label:e.label}})));var r=this.getSelectionItems(this.plugin.managers.structure.hierarchy.selection.structures);1===r.length&&(r[0][0].initiallyExpanded=!0);var i=[];return r.length>0&&i.push.apply(i,r),e.length>0&&i.push.apply(i,e),i},enumerable:!1,configurable:!0}),t.prototype.getToggleBindingLabel=function(){var e,t=this.plugin.state.behaviors.transforms.get(f.FocusLoci.id);if(!t)return"";var r=null===(e=t.params)||void 0===e?void 0:e.bindings.clickFocus;return!r||m.a.isEmpty(r)?"":m.a.formatTriggers(r)},t.prototype.render=function(){var e=this.plugin.managers.structure.focus.current,t=(null==e?void 0:e.label)||"Nothing Focused",r="Click to Center Camera";if(!e){r="Select focus using the menu";var n=this.getToggleBindingLabel();n&&(r+="\nor use '"+n+"' on element")}return i.createElement(i.Fragment,null,i.createElement("div",{className:"msp-flex-row"},i.createElement(u.Button,{noOverflow:!0,onClick:this.focusCamera,title:r,onMouseEnter:this.highlightCurrent,onMouseLeave:this.clearHighlights,disabled:this.isDisabled||!e,style:{textAlignLast:e?"left":void 0}},t),e&&i.createElement(u.IconButton,{svg:g.CancelOutlinedSvg,onClick:this.clear,title:"Clear",className:"msp-form-control",flex:!0,disabled:this.isDisabled}),i.createElement(u.ToggleButton,{icon:g.CenterFocusStrongSvg,title:"Select a focus target to center on an show its surroundings. Hold shift to focus on multiple targets.",toggle:this.toggleAction,isSelected:this.state.showAction,disabled:this.isDisabled,style:{flex:"0 0 40px",padding:0}})),this.state.showAction&&i.createElement(s.a,{items:this.actionItems,onSelect:this.selectAction}))},t}(o.PluginUIComponent),_=r(189),S=r(213),x=r(13),O=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.item=function(e){var r,n,i,a,o,s,u,c,l,f,p=t.plugin.managers.structure.hierarchy.seletionSet;switch(e.kind){case"model":(m=null===(r=e.cell.obj)||void 0===r?void 0:r.data)&&d.Model.TrajectoryInfo.get(m).size>1&&(f=(null===(n=e.cell.obj)||void 0===n?void 0:n.data.entryId)+" | Model "+(d.Model.TrajectoryInfo.get(m).index+1)+" of "+d.Model.TrajectoryInfo.get(m).size),f=(null===(i=e.cell.obj)||void 0===i?void 0:i.data.entryId)+" | "+(null===(a=e.cell.obj)||void 0===a?void 0:a.label);break;case"structure":var m;if((m=null===(o=e.cell.obj)||void 0===o?void 0:o.data.models[0])&&d.Model.TrajectoryInfo.get(m).size>1){f=m.entryId+" | "+(null===(s=e.cell.obj)||void 0===s?void 0:s.label)+" (Model "+(d.Model.TrajectoryInfo.get(m).index+1)+" of "+d.Model.TrajectoryInfo.get(m).size+")";break}if(m){f=m.entryId+" | "+(null===(u=e.cell.obj)||void 0===u?void 0:u.label);break}f=""+(null===(c=e.cell.obj)||void 0===c?void 0:c.label);break;default:f=null===(l=e.cell.obj)||void 0===l?void 0:l.label}return{kind:"item",label:f||e.kind,selected:p.has(e.cell.transform.ref),value:[e]}},t.getTrajectoryItems=function(e){var r;return 0===e.models.length?t.item(e):Object(n.__spreadArrays)([s.a.Header(null===(r=e.cell.obj)||void 0===r?void 0:r.label)],e.models.map(t.getModelItems))},t.getModelItems=function(e){var r,i,a;if(0===e.structures.length)return t.item(e);if(1===e.structures.length){var o=t.plugin.managers.structure.hierarchy.seletionSet,u=e.structures[0];return{label:(null===(r=e.cell.obj)||void 0===r?void 0:r.label)+" | "+(null===(i=u.cell.obj)||void 0===i?void 0:i.label),selected:o.has(u.cell.transform.ref),value:[e,u]}}return Object(n.__spreadArrays)([s.a.Header(null===(a=e.cell.obj)||void 0===a?void 0:a.label)],e.structures.map(t.item))},t.selectHierarchy=function(e){if(e&&0!==e.length){for(var r=[],n=0,i=e;n<i.length;n++)for(var a=0,o=i[n].value;a<o.length;a++){var s=o[a];r.push(s)}t.plugin.managers.structure.hierarchy.updateCurrent(r,e[0].selected?"remove":"add")}},t.toggleHierarchy=function(){return t.setState({show:"hierarchy"!==t.state.show?"hierarchy":void 0})},t.togglePreset=function(){return t.setState({show:"presets"!==t.state.show?"presets":void 0})},t.applyPreset=function(e){if(t.setState({show:void 0}),e){var r=t.plugin.managers.structure,n=r.hierarchy.selection.trajectories;r.hierarchy.applyPreset(n,e.value)}},t.updateStructureModel=function(e){return Object(n.__awaiter)(t,void 0,void 0,(function(){var t,r;return Object(n.__generator)(this,(function(n){return t=this.plugin.managers.structure.hierarchy.selection,r=t.structures[0].model,this.plugin.state.updateTransform(this.plugin.state.data,r.cell.transform.ref,e,"Model Index"),[2]}))}))},t.updateStructure=function(e){var r=t.plugin.managers.structure.hierarchy.selection.structures[0];return t.plugin.managers.structure.hierarchy.updateStructure(r,e)},t}return Object(n.__extends)(t,e),t.prototype.defaultState=function(){return{header:"Structure",isCollapsed:!1,isBusy:!1,brand:{accent:"purple",svg:g.MoleculeSvg}}},t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.managers.structure.hierarchy.behaviors.selection,(function(){return e.forceUpdate()})),this.subscribe(this.plugin.behaviors.state.isBusy,(function(t){e.setState({isBusy:t})}))},Object.defineProperty(t.prototype,"hierarchyItems",{get:function(){var e=this.plugin.managers.structure.hierarchy.current,t=[];return e.trajectories.length>1&&t.push(Object(n.__spreadArrays)([s.a.Header("Trajectories")],e.trajectories.map(this.item))),(e.models.length>1||e.trajectories.length>1)&&t.push(Object(n.__spreadArrays)([s.a.Header("Models")],e.models.map(this.item))),1===e.trajectories.length&&1===e.models.length?t.push.apply(t,e.structures.map(this.item)):e.structures.length>0&&t.push(Object(n.__spreadArrays)([s.a.Header("Structures")],e.structures.map(this.item))),t},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"isEmpty",{get:function(){var e=this.plugin.managers.structure.hierarchy.current,t=e.structures,r=e.models;return 0===e.trajectories.length&&0===r.length&&0===t.length},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"label",{get:function(){var e,t,r,n,i,a,o,s,u,c,l,f,p,m,h=this.plugin.managers.structure.hierarchy.selection,g=h.structures,v=h.models,b=h.trajectories;if(1===g.length)return(null===(t=null===(e=(w=g[0]).model)||void 0===e?void 0:e.trajectory)||void 0===t?void 0:t.models)&&1===w.model.trajectory.models.length?null===(r=w.cell.obj)||void 0===r?void 0:r.data.label:w.model?(null===(n=w.model.cell.obj)||void 0===n?void 0:n.label)+" | "+(null===(i=w.cell.obj)||void 0===i?void 0:i.data.label):null===(a=w.cell.obj)||void 0===a?void 0:a.data.label;if(g.length>1){for(var y=g[0],_=null===(o=null==y?void 0:y.model)||void 0===o?void 0:o.trajectory,S=!0,x=0,O=g;x<O.length;x++){var w;if((null===(s=null==(w=O[x])?void 0:w.model)||void 0===s?void 0:s.trajectory)!==_){S=!1;break}}return S&&_?(null===(u=_.cell.obj)||void 0===u?void 0:u.label)+" | "+g.length+" structures":g.length+" structures"}if(v.length>0){_=v[0].trajectory;if(1===v.length){var C=null===(c=v[0].cell.obj)||void 0===c?void 0:c.data;return C&&d.Model.TrajectoryInfo.get(C).size>1?(null===(l=null==_?void 0:_.cell.obj)||void 0===l?void 0:l.label)+" | Model "+(d.Model.TrajectoryInfo.get(C).index+1)+" of "+d.Model.TrajectoryInfo.get(C).size:(null===(f=null==_?void 0:_.cell.obj)||void 0===f?void 0:f.label)+" | Model"}S=!0;for(var j=0,P=v;j<P.length;j++){if(P[j].trajectory!==_){S=!1;break}}return S?(null===(p=null==_?void 0:_.cell.obj)||void 0===p?void 0:p.label)+" | "+v.length+" models":v.length+" models"}return b.length>0?1===b.length?(null===(m=b[0].cell.obj)||void 0===m?void 0:m.label)+" trajectory":b.length+" trajectories":0===b.length&&0===v.length&&0===g.length?"Nothing Loaded":"Nothing Selected"},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"presetActions",{get:function(){var e=[],t=this.plugin.managers.structure.hierarchy.selection.trajectories;if(1!==t.length)return e;for(var r=0,n=this.plugin.builders.structure.hierarchy.getPresets(t[0].cell.obj);r<n.length;r++){var i=n[r];e.push(s.a.Item(i.display.name,i,{description:i.display.description}))}return e},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"modelIndex",{get:function(){var e,t,r=this.plugin.managers.structure.hierarchy.selection;if(1!==r.structures.length)return null;var n=r.structures[0].model;if(!n||n.cell.transform.transformer!==a.StateTransforms.Model.ModelFromTrajectory)return null;if(!n.cell.obj||d.Model.TrajectoryInfo.get(n.cell.obj.data).size<=1)return null;var o=null===(e=n.cell.params)||void 0===e?void 0:e.definition;return o?i.createElement(c.ParameterControls,{params:o,values:null===(t=n.cell.params)||void 0===t?void 0:t.values,onChangeValues:this.updateStructureModel,isDisabled:this.state.isBusy}):null},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"structureType",{get:function(){var e,t=this.plugin.managers.structure.hierarchy.selection;if(1!==t.structures.length)return null;var r=t.structures[0];return(null===(e=r.cell.params)||void 0===e?void 0:e.definition)&&r.cell.parent?i.createElement(_.UpdateTransformControl,{state:r.cell.parent,transform:r.cell.transform,customHeader:"none",customUpdate:this.updateStructure,noMargin:!0,autoHideApply:!0}):null},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"transform",{get:function(){var e=this.plugin.managers.structure.hierarchy.selection;if(1!==e.structures.length)return null;var t=e.structures[0];if(!t.cell.parent)return null;var r=x.StateSelection.tryFindDecorator(this.plugin.state.data,t.cell.transform.ref,a.StateTransforms.Model.TransformStructureConformation);return r?i.createElement(u.ExpandGroup,{header:"Conformation Transform"},i.createElement(_.UpdateTransformControl,{state:r.parent,transform:r.transform,customHeader:"none",noMargin:!0,autoHideApply:!0})):void 0},enumerable:!1,configurable:!0}),t.prototype.renderControls=function(){var e=this.state.isBusy||this.isEmpty,t=this.presetActions,r=this.label;return i.createElement(i.Fragment,null,i.createElement("div",{className:"msp-flex-row",style:{marginTop:"1px"}},i.createElement(u.Button,{noOverflow:!0,flex:!0,onClick:this.toggleHierarchy,disabled:e,title:r},r),t.length>0&&i.createElement(u.IconButton,{svg:g.BookmarksOutlinedSvg,className:"msp-form-control",flex:"40px",onClick:this.togglePreset,title:"Apply a structure presets to the current hierarchy.",toggleState:"presets"===this.state.show,disabled:e})),"hierarchy"===this.state.show&&i.createElement(s.a,{items:this.hierarchyItems,onSelect:this.selectHierarchy,multiselect:!0}),"presets"===this.state.show&&i.createElement(s.a,{items:t,onSelect:this.applyPreset}),this.modelIndex,this.structureType,this.transform,i.createElement("div",{style:{marginTop:"6px"}},i.createElement(y,null),i.createElement(S.StructureSelectionStatsControls,{hideOnEmpty:!0})))},t}(o.CollapsableControls)},function(e,t,r){"use strict";r.r(t),r.d(t,"SimpleSettingsControl",(function(){return h}));var n=r(0),i=r(158),a=r(3),o=r(146),s=r(27),u=r(13),c=r(24),l=r(2);var d,f=r(33),p=r(73),m=r(195),h=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return Object(n.__extends)(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.events.canvas3d.settingsUpdated,(function(){return e.forceUpdate()})),this.subscribe(this.plugin.canvas3d.camera.stateChanged,(function(t){void 0===t.radiusMax&&void 0===t.radius||e.forceUpdate()}))},t.prototype.render=function(){return this.plugin.canvas3d?a.createElement(a.Fragment,null,a.createElement(p.ParameterMappingControl,{mapping:b}),a.createElement(m.ViewportHelpContent,null)):null},t}(f.PluginUIComponent),g={sequence:"Sequence",log:"Log",left:"Left 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0===t?void 0:t.controls;if(n){var i=[];"none"!==n.top&&i.push(["sequence",g.sequence]),"none"!==n.bottom&&i.push(["log",g.log]),"none"!==n.left&&i.push(["left",g.left]),r.layout.options=i}return r},target:function(e){var t,r,n=null===(t=e.spec.layout)||void 0===t?void 0:t.controls,i=e.layout.state.regionState,a=[];return"hidden"===i.top||n&&"none"===n.top||a.push("sequence"),"hidden"===i.bottom||n&&"none"===n.bottom||a.push("log"),"hidden"===i.left||n&&"none"===n.left||a.push("left"),{canvas:null===(r=e.canvas3d)||void 0===r?void 0:r.props,layout:a}}},function(e){var t=e.values,r=e.update,n=e.apply;return{params:"function"==typeof d.params?d.params:function(e){return d.params},getTarget:d.target,getValues:t,update:function(e,t){var n=d.target(t);return Object(i.b)(n,(function(n){return r(e,n,t)}))},apply:n||function(){}}})({values:function(e,t){var r=e.canvas,i=r.renderer;return{layout:e.layout,spin:{spin:!!r.trackball.spin,speed:r.trackball.spinSpeed},camera:r.camera,background:{color:i.backgroundColor,transparent:r.transparentBackground},lighting:{renderStyle:i.style,occlusion:r.postprocessing.occlusion,outline:r.postprocessing.outline,fog:r.cameraFog},clipping:Object(n.__assign)(Object(n.__assign)({},r.cameraClipping),r.renderer.clip)}},update:function(e,t){var r=t.canvas;r.trackball.spin=e.spin.spin,r.trackball.spinSpeed=e.spin.speed,r.camera=e.camera,r.transparentBackground=e.background.transparent,r.renderer.backgroundColor=e.background.color,r.renderer.style=e.lighting.renderStyle,r.postprocessing.occlusion=e.lighting.occlusion,r.postprocessing.outline=e.lighting.outline,r.cameraFog=e.lighting.fog,r.cameraClipping={radius:e.clipping.radius,far:e.clipping.far},r.renderer.clip={variant:e.clipping.variant,objects:e.clipping.objects},t.layout=e.layout},apply:function(e,t){return Object(n.__awaiter)(this,void 0,void 0,(function(){var r,a;return Object(n.__generator)(this,(function(n){switch(n.label){case 0:return[4,s.PluginCommands.Canvas3D.SetSettings(t,{settings:e.canvas})];case 1:return n.sent(),r=e.layout.indexOf("left")<0,a=Object(i.b)(t.layout.state,(function(n){n.regionState.top=e.layout.indexOf("sequence")>=0?"full":"hidden",n.regionState.bottom=e.layout.indexOf("log")>=0?"full":"hidden",n.regionState.left=r?"hidden":"none"===t.behaviors.layout.leftPanelTabName.value?"collapsed":"full"})),[4,s.PluginCommands.Layout.Update(t,{state:a})];case 2:return n.sent(),r&&s.PluginCommands.State.SetCurrentObject(t,{state:t.state.data,ref:u.StateTransform.RootRef}),[2]}}))}))}})},function(e,t,r){"use strict";r.d(t,"a",(function(){return m}));var n=r(105),i=r(1),a=r(24),o=r(5),s=r(2),u=r(85),c=r(42),l=r(44),d=r(204),f=r(29),p=r(70),m={backgroundColor:s.ParamDefinition.Color(Object(a.Color)(0),{description:"Background color of the 3D canvas"}),pickingAlphaThreshold:s.ParamDefinition.Numeric(.5,{min:0,max:1,step:.01},{description:"The minimum opacity value needed for an object to be pickable."}),interiorDarkening:s.ParamDefinition.Numeric(.5,{min:0,max:1,step:.01}),interiorColorFlag:s.ParamDefinition.Boolean(!0,{label:"Use Interior Color"}),interiorColor:s.ParamDefinition.Color(a.Color.fromNormalizedRgb(.3,.3,.3)),highlightColor:s.ParamDefinition.Color(a.Color.fromNormalizedRgb(1,.4,.6)),selectColor:s.ParamDefinition.Color(a.Color.fromNormalizedRgb(.2,1,.1)),xrayEdgeFalloff:s.ParamDefinition.Numeric(1,{min:0,max:3,step:.1}),style:s.ParamDefinition.MappedStatic("matte",{custom:s.ParamDefinition.Group({lightIntensity:s.ParamDefinition.Numeric(.6,{min:0,max:1,step:.01}),ambientIntensity:s.ParamDefinition.Numeric(.4,{min:0,max:1,step:.01}),metalness:s.ParamDefinition.Numeric(0,{min:0,max:1,step:.01}),roughness:s.ParamDefinition.Numeric(1,{min:0,max:1,step:.01}),reflectivity:s.ParamDefinition.Numeric(.5,{min:0,max:1,step:.01})},{isExpanded:!0}),flat:s.ParamDefinition.Group({}),matte:s.ParamDefinition.Group({}),glossy:s.ParamDefinition.Group({}),metallic:s.ParamDefinition.Group({}),plastic:s.ParamDefinition.Group({})},{label:"Lighting",description:"Style in which the 3D scene is rendered/lighted"}),clip:s.ParamDefinition.Group({variant:s.ParamDefinition.Select("instance",s.ParamDefinition.arrayToOptions(["instance","pixel"])),objects:s.ParamDefinition.ObjectList({type:s.ParamDefinition.Select("plane",s.ParamDefinition.objectToOptions(u.a.Type,(function(e){return Object(c.d)(e)}))),invert:s.ParamDefinition.Boolean(!1),position:s.ParamDefinition.Vec3(Object(i.Vec3)()),rotation:s.ParamDefinition.Group({axis:s.ParamDefinition.Vec3(i.Vec3.create(1,0,0)),angle:s.ParamDefinition.Numeric(0,{min:-180,max:180,step:1},{description:"Angle in Degrees"})},{isExpanded:!0}),scale:s.ParamDefinition.Vec3(i.Vec3.create(1,1,1))},(function(e){return Object(c.d)(e.type)}))})};function h(e){switch(e.name){case"custom":return e.params;case"flat":return{lightIntensity:0,ambientIntensity:1,metalness:0,roughness:.4,reflectivity:.5};case"matte":return{lightIntensity:.7,ambientIntensity:.3,metalness:0,roughness:1,reflectivity:.5};case"glossy":return{lightIntensity:.7,ambientIntensity:.3,metalness:0,roughness:.4,reflectivity:.5};case"metallic":return{lightIntensity:.7,ambientIntensity:.7,metalness:.6,roughness:.6,reflectivity:.5};case"plastic":return{lightIntensity:.7,ambientIntensity:.3,metalness:0,roughness:.2,reflectivity:.5}}}var g,v=Object(i.Quat)();function b(e,t){for(var r=(null==t?void 0:t.objects)||{type:new Array(5).fill(1),invert:new Array(5).fill(!1),position:new Array(15).fill(0),rotation:new Array(20).fill(0),scale:new Array(15).fill(1)},n=r.type,a=r.invert,o=r.position,s=r.rotation,c=r.scale,d=0,f=e.objects.length;d<f;++d){var p=e.objects[d];n[d]=u.a.Type[p.type],a[d]=p.invert,i.Vec3.toArray(p.position,o,3*d),i.Quat.toArray(i.Quat.setAxisAngle(v,p.rotation.axis,Object(l.c)(p.rotation.angle)),s,4*d),i.Vec3.toArray(p.scale,c,3*d)}return{variant:e.variant,objects:{count:e.objects.length,type:n,invert:a,position:o,rotation:s,scale:c}}}!function(e){e.create=function(e,t){void 0===t&&(t={});var r=e.gl,u=e.state,c=e.stats,l=e.extensions.fragDepth,g=s.ParamDefinition.merge(m,s.ParamDefinition.getDefaultValues(m),t),v=h(g.style),y=b(g.clip),_=Object(n.a)(),S=i.Vec2.create(r.drawingBufferWidth,r.drawingBufferHeight),x=a.Color.toVec3Normalized(Object(i.Vec3)(),g.backgroundColor),O=!1,w=Object(d.a)(r,"image-depth"),C=[["tDepth",w]],j=Object(i.Mat4)(),P=Object(i.Mat4)(),E=Object(i.Mat4)(),A=Object(i.Mat4)(),D=Object(i.Mat4)(),T=Object(i.Mat4)(),I=Object(i.Mat4)(),M=Object(i.Vec3)(),k=Object(i.Vec2)(),B={uModel:o.e.create(i.Mat4.identity()),uView:o.e.create(j),uInvView:o.e.create(P),uModelView:o.e.create(E),uInvModelView:o.e.create(A),uInvProjection:o.e.create(D),uProjection:o.e.create(Object(i.Mat4)()),uModelViewProjection:o.e.create(T),uInvModelViewProjection:o.e.create(I),uIsOrtho:o.e.create(1),uViewOffset:o.e.create(k),uPixelRatio:o.e.create(e.pixelRatio),uViewportHeight:o.e.create(_.height),uViewport:o.e.create(n.a.toVec4(Object(i.Vec4)(),_)),uDrawingBufferSize:o.e.create(S),uCameraPosition:o.e.create(Object(i.Vec3)()),uCameraDir:o.e.create(M),uNear:o.e.create(1),uFar:o.e.create(1e4),uFogNear:o.e.create(1),uFogFar:o.e.create(1e4),uFogColor:o.e.create(x),uRenderWboit:o.e.create(!1),uTransparentBackground:o.e.create(!1),uClipObjectType:o.e.create(y.objects.type),uClipObjectInvert:o.e.create(y.objects.invert),uClipObjectPosition:o.e.create(y.objects.position),uClipObjectRotation:o.e.create(y.objects.rotation),uClipObjectScale:o.e.create(y.objects.scale),uLightIntensity:o.e.create(v.lightIntensity),uAmbientIntensity:o.e.create(v.ambientIntensity),uMetalness:o.e.create(v.metalness),uRoughness:o.e.create(v.roughness),uReflectivity:o.e.create(v.reflectivity),uPickingAlphaThreshold:o.e.create(g.pickingAlphaThreshold),uInteriorDarkening:o.e.create(g.interiorDarkening),uInteriorColorFlag:o.e.create(g.interiorColorFlag),uInteriorColor:o.e.create(a.Color.toVec3Normalized(Object(i.Vec3)(),g.interiorColor)),uHighlightColor:o.e.create(a.Color.toVec3Normalized(Object(i.Vec3)(),g.highlightColor)),uSelectColor:o.e.create(a.Color.toVec3Normalized(Object(i.Vec3)(),g.selectColor)),uXrayEdgeFalloff:o.e.create(g.xrayEdgeFalloff)},V=Object.entries(B),R=!0,L=function(e,t){if(!e.state.disposed&&e.state.visible&&(e.state.pickable||"p"!==t[0])){var n=!1;e.state.noClip?0!==e.values.dClipObjectCount.ref.value&&(o.e.update(e.values.dClipObjectCount,0),n=!0):(e.values.dClipObjectCount.ref.value!==y.objects.count&&(o.e.update(e.values.dClipObjectCount,y.objects.count),n=!0),e.values.dClipVariant.ref.value!==y.variant&&(o.e.update(e.values.dClipVariant,y.variant),n=!0)),n&&e.update();var i=e.getProgram(t);u.currentProgramId!==i.id&&(R=!0,i.use()),R&&(i.setUniforms(V),R=!1),e.values.dRenderMode?(u.disable(r.CULL_FACE),u.frontFace(r.CCW),"colorBlended"===t&&("volume"!==e.values.dRenderMode.ref.value&&l?(u.enable(r.DEPTH_TEST),u.depthMask(1===e.values.uAlpha.ref.value)):(u.disable(r.DEPTH_TEST),u.depthMask(!1)))):(e.values.dDoubleSided?e.values.dDoubleSided.ref.value||e.values.hasReflection.ref.value?u.disable(r.CULL_FACE):u.enable(r.CULL_FACE):u.disable(r.CULL_FACE),e.values.dFlipSided&&e.values.dFlipSided.ref.value?(u.frontFace(r.CW),u.cullFace(r.FRONT)):(u.frontFace(r.CCW),u.cullFace(r.BACK))),e.render(t,C)}},N=function(e,t,n,a){Object(f.arrayMapUpsert)(C,"tDepth",n||w),o.e.update(B.uModel,e.view),o.e.update(B.uModelView,i.Mat4.mul(E,e.view,t.view)),o.e.update(B.uInvModelView,i.Mat4.invert(A,E)),o.e.update(B.uModelViewProjection,i.Mat4.mul(T,E,t.projection)),o.e.update(B.uInvModelViewProjection,i.Mat4.invert(I,T)),o.e.updateIfChanged(B.uRenderWboit,a),u.enable(r.SCISSOR_TEST),u.colorMask(!0,!0,!0,!0);var s=_.x,c=_.y,l=_.width,d=_.height;r.viewport(s,c,l,d),r.scissor(s,c,l,d),R=!0,u.currentRenderItemId=-1},F=function(e,t,n){u.disable(r.BLEND),u.enable(r.DEPTH_TEST),u.depthMask(!0),N(e,t,n,!1);for(var i=e.renderables,a=0,o=i.length;a<o;++a){var s=i[a];s.state.opaque&&L(s,"colorBlended")}},U=function(e,t,n){u.enable(r.DEPTH_TEST),N(e,t,n,!1);var i=e.renderables;O?u.blendFunc(r.ONE,r.ONE_MINUS_SRC_ALPHA):u.blendFuncSeparate(r.SRC_ALPHA,r.ONE_MINUS_SRC_ALPHA,r.ONE,r.ONE_MINUS_SRC_ALPHA),u.enable(r.BLEND),u.depthMask(!0);for(var a=0,o=i.length;a<o;++a){!(s=i[a]).state.opaque&&s.state.writeDepth&&L(s,"colorBlended")}u.depthMask(!1);for(a=0,o=i.length;a<o;++a){var s;(s=i[a]).state.opaque||s.state.writeDepth||L(s,"colorBlended")}};return{clear:function(e){u.enable(r.SCISSOR_TEST),u.enable(r.DEPTH_TEST),u.colorMask(!0,!0,!0,!0),u.depthMask(!0),O?u.clearColor(0,0,0,0):e?u.clearColor(x[0],x[1],x[2],1):u.clearColor(1,1,1,1),r.clear(r.COLOR_BUFFER_BIT|r.DEPTH_BUFFER_BIT)},clearDepth:function(){u.enable(r.SCISSOR_TEST),u.enable(r.DEPTH_TEST),u.depthMask(!0),r.clear(r.DEPTH_BUFFER_BIT)},update:function(e){o.e.update(B.uView,e.view),o.e.update(B.uInvView,i.Mat4.invert(P,e.view)),o.e.update(B.uProjection,e.projection),o.e.update(B.uInvProjection,i.Mat4.invert(D,e.projection)),o.e.updateIfChanged(B.uIsOrtho,"orthographic"===e.state.mode?1:0),o.e.update(B.uViewOffset,e.viewOffset.enabled?i.Vec2.set(k,16*e.viewOffset.offsetX,16*e.viewOffset.offsetY):i.Vec2.set(k,0,0)),o.e.update(B.uCameraPosition,e.state.position),o.e.update(B.uCameraDir,i.Vec3.normalize(M,i.Vec3.sub(M,e.state.target,e.state.position))),o.e.updateIfChanged(B.uFar,e.far),o.e.updateIfChanged(B.uNear,e.near),o.e.updateIfChanged(B.uFogFar,e.fogFar),o.e.updateIfChanged(B.uFogNear,e.fogNear),o.e.updateIfChanged(B.uTransparentBackground,O)},renderPick:function(e,t,n,i){u.disable(r.BLEND),u.enable(r.DEPTH_TEST),u.depthMask(!0),N(e,t,i,!1);for(var a=e.renderables,o=0,s=a.length;o<s;++o)a[o].state.colorOnly||L(a[o],n)},renderDepth:function(e,t,n){u.disable(r.BLEND),u.enable(r.DEPTH_TEST),u.depthMask(!0),N(e,t,n,!1);for(var i=e.renderables,a=0,o=i.length;a<o;++a)L(i[a],"depth")},renderBlended:function(e,t,r){F(e,t,r),U(e,t,r)},renderBlendedOpaque:F,renderBlendedTransparent:U,renderBlendedVolumeOpaque:function(e,t,n){var i;u.blendFunc(r.ONE,r.ONE_MINUS_SRC_ALPHA),u.enable(r.BLEND),N(e,t,n,!1);for(var a=e.renderables,o=0,s=a.length;o<s;++o){var c=a[o];1!==Object(p.a)(c.values.alpha.ref.value*c.state.alphaFactor,0,1)||1===c.values.transparencyAverage.ref.value||(null===(i=c.values.dXrayShaded)||void 0===i?void 0:i.ref.value)||L(c,"colorBlended")}},renderBlendedVolumeTransparent:function(e,t,n){var i;u.blendFunc(r.ONE,r.ONE_MINUS_SRC_ALPHA),u.enable(r.BLEND),N(e,t,n,!1);for(var a=e.renderables,o=0,s=a.length;o<s;++o){var c=a[o];(Object(p.a)(c.values.alpha.ref.value*c.state.alphaFactor,0,1)<1||c.values.transparencyAverage.ref.value>0||(null===(i=c.values.dXrayShaded)||void 0===i?void 0:i.ref.value))&&L(c,"colorBlended")}},renderWboitOpaque:function(e,t,n){var i,a,o;u.disable(r.BLEND),u.enable(r.DEPTH_TEST),u.depthMask(!0),N(e,t,n,!1);for(var s=e.renderables,c=0,l=s.length;c<l;++c){var d=s[c];1!==Object(p.a)(d.values.alpha.ref.value*d.state.alphaFactor,0,1)||1===d.values.transparencyAverage.ref.value||"volume"===(null===(i=d.values.dRenderMode)||void 0===i?void 0:i.ref.value)||(null===(a=d.values.dPointFilledCircle)||void 0===a?void 0:a.ref.value)||(null===(o=d.values.dXrayShaded)||void 0===o?void 0:o.ref.value)||L(d,"colorWboit")}},renderWboitTransparent:function(e,t,r){var n,i,a;N(e,t,r,!0);for(var o=e.renderables,s=0,u=o.length;s<u;++s){var c=o[s];(Object(p.a)(c.values.alpha.ref.value*c.state.alphaFactor,0,1)<1||c.values.transparencyAverage.ref.value>0||"volume"===(null===(n=c.values.dRenderMode)||void 0===n?void 0:n.ref.value)||(null===(i=c.values.dPointFilledCircle)||void 0===i?void 0:i.ref.value)||c.values.uBackgroundColor||(null===(a=c.values.dXrayShaded)||void 0===a?void 0:a.ref.value))&&L(c,"colorWboit")}},setProps:function(e){void 0!==e.backgroundColor&&e.backgroundColor!==g.backgroundColor&&(g.backgroundColor=e.backgroundColor,a.Color.toVec3Normalized(x,g.backgroundColor),o.e.update(B.uFogColor,i.Vec3.copy(B.uFogColor.ref.value,x))),void 0!==e.pickingAlphaThreshold&&e.pickingAlphaThreshold!==g.pickingAlphaThreshold&&(g.pickingAlphaThreshold=e.pickingAlphaThreshold,o.e.update(B.uPickingAlphaThreshold,g.pickingAlphaThreshold)),void 0!==e.interiorDarkening&&e.interiorDarkening!==g.interiorDarkening&&(g.interiorDarkening=e.interiorDarkening,o.e.update(B.uInteriorDarkening,g.interiorDarkening)),void 0!==e.interiorColorFlag&&e.interiorColorFlag!==g.interiorColorFlag&&(g.interiorColorFlag=e.interiorColorFlag,o.e.update(B.uInteriorColorFlag,g.interiorColorFlag)),void 0!==e.interiorColor&&e.interiorColor!==g.interiorColor&&(g.interiorColor=e.interiorColor,o.e.update(B.uInteriorColor,a.Color.toVec3Normalized(B.uInteriorColor.ref.value,g.interiorColor))),void 0!==e.highlightColor&&e.highlightColor!==g.highlightColor&&(g.highlightColor=e.highlightColor,o.e.update(B.uHighlightColor,a.Color.toVec3Normalized(B.uHighlightColor.ref.value,g.highlightColor))),void 0!==e.selectColor&&e.selectColor!==g.selectColor&&(g.selectColor=e.selectColor,o.e.update(B.uSelectColor,a.Color.toVec3Normalized(B.uSelectColor.ref.value,g.selectColor))),void 0!==e.xrayEdgeFalloff&&e.xrayEdgeFalloff!==g.xrayEdgeFalloff&&(g.xrayEdgeFalloff=e.xrayEdgeFalloff,o.e.update(B.uXrayEdgeFalloff,g.xrayEdgeFalloff)),void 0!==e.style&&(g.style=e.style,Object.assign(v,h(e.style)),o.e.updateIfChanged(B.uLightIntensity,v.lightIntensity),o.e.updateIfChanged(B.uAmbientIntensity,v.ambientIntensity),o.e.updateIfChanged(B.uMetalness,v.metalness),o.e.updateIfChanged(B.uRoughness,v.roughness),o.e.updateIfChanged(B.uReflectivity,v.reflectivity)),void 0===e.clip||Object(o.g)(e.clip,g.clip)||(g.clip=e.clip,Object.assign(y,b(e.clip,y)),o.e.update(B.uClipObjectPosition,y.objects.position),o.e.update(B.uClipObjectRotation,y.objects.rotation),o.e.update(B.uClipObjectScale,y.objects.scale),o.e.update(B.uClipObjectType,y.objects.type))},setViewport:function(e,t,a,s){r.viewport(e,t,a,s),r.scissor(e,t,a,s),e===_.x&&t===_.y&&a===_.width&&s===_.height||(n.a.set(_,e,t,a,s),o.e.update(B.uViewportHeight,s),o.e.update(B.uViewport,i.Vec4.set(B.uViewport.ref.value,e,t,a,s)))},setTransparentBackground:function(e){O=e},setDrawingBufferSize:function(e,t){e===S[0]&&t===S[1]||o.e.update(B.uDrawingBufferSize,i.Vec2.set(S,e,t))},props:g,get stats(){return{programCount:e.stats.resourceCounts.program,shaderCount:e.stats.resourceCounts.shader,attributeCount:e.stats.resourceCounts.attribute,elementsCount:e.stats.resourceCounts.elements,framebufferCount:e.stats.resourceCounts.framebuffer,renderbufferCount:e.stats.resourceCounts.renderbuffer,textureCount:e.stats.resourceCounts.texture,vertexArrayCount:e.stats.resourceCounts.vertexArray,drawCount:c.drawCount,instanceCount:c.instanceCount,instancedDrawCount:c.instancedDrawCount}},dispose:function(){}}}}(g||(g={})),t.b=g},function(e,t,r){"use strict";r.d(t,"b",(function(){return m})),r.d(t,"a",(function(){return n}));var n,i=r(0),a=r(1),o=r(105),s=r(90),u=r(2),c=r(44),l=r(61),d=(s.a,s.b),f=l.a.Trigger,p={dragRotate:Object(l.a)([f(1,d.create())],"Rotate","Drag using ${triggers}"),dragRotateZ:Object(l.a)([f(1,d.create({shift:!0}))],"Rotate around z-axis","Drag using ${triggers}"),dragPan:Object(l.a)([f(2,d.create()),f(1,d.create({control:!0}))],"Pan","Drag using ${triggers}"),dragZoom:l.a.Empty,dragFocus:Object(l.a)([f(8,d.create())],"Focus","Drag using ${triggers}"),dragFocusZoom:Object(l.a)([f(4,d.create())],"Focus and zoom","Drag using ${triggers}"),scrollZoom:Object(l.a)([f(4,d.create())],"Zoom","Scroll using ${triggers}"),scrollFocus:Object(l.a)([f(4,d.create({shift:!0}))],"Clip","Scroll using ${triggers}"),scrollFocusZoom:l.a.Empty},m={noScroll:u.ParamDefinition.Boolean(!0,{isHidden:!0}),rotateSpeed:u.ParamDefinition.Numeric(5,{min:1,max:10,step:1}),zoomSpeed:u.ParamDefinition.Numeric(7,{min:1,max:15,step:1}),panSpeed:u.ParamDefinition.Numeric(1,{min:.1,max:5,step:.1}),spin:u.ParamDefinition.Boolean(!1,{description:"Spin the 3D scene around the x-axis in view 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m=l.a.match(n.bindings.dragRotate,c,d),h=l.a.match(n.bindings.dragRotateZ,c,d),g=l.a.match(n.bindings.dragPan,c,d),b=l.a.match(n.bindings.dragZoom,c,d),y=l.a.match(n.bindings.dragFocus,c,d),x=l.a.match(n.bindings.dragFocusZoom,c,d);(function(e,t){a.Vec2.set(R,(e-.5*s.width-s.x)/(.5*s.width),(s.height+2*(s.y-t))/s.width)})(o,u),function(e,t){a.Vec2.set(V,(e-s.x)/s.width,(t-s.y)/s.height)}(o,u),f&&(m&&(a.Vec2.copy(S,R),a.Vec2.copy(_,S)),h&&(a.Vec2.copy(C,R),a.Vec2.copy(w,C)),(b||x)&&(a.Vec2.copy(P,V),a.Vec2.copy(E,P)),y&&(a.Vec2.copy(A,V),a.Vec2.copy(D,A)),g&&(a.Vec2.copy(T,V),a.Vec2.copy(I,T)));m&&a.Vec2.copy(S,R);h&&a.Vec2.copy(C,R);(b||x)&&a.Vec2.copy(E,V);y&&a.Vec2.copy(D,V);if(x){var O=a.Vec3.distance(t.state.position,t.state.target);t.setState({radius:O/5})}g&&a.Vec2.copy(I,V)})),p=e.interactionEnd.subscribe((function(){v=!1})),h=e.wheel.subscribe((function(e){var t=e.x,r=e.y,i=e.dx,a=e.dy,o=e.dz,s=e.buttons,u=e.modifiers;if(Y(t,r))return;var d=Object(c.a)(i,a,o);l.a.match(n.bindings.scrollZoom,s,u)&&(E[1]+=1e-4*d);l.a.match(n.bindings.scrollFocus,s,u)&&(D[1]+=1e-4*d)})),g=e.pinch.subscribe((function(e){var t=e.fraction,r=e.buttons,i=e.modifiers;l.a.match(n.bindings.scrollZoom,r,i)&&(v=!0,E[1]+=.1*(t-1))})),v=!1,b=Object(a.Vec3)(),y=Object(a.Vec3)(),_=Object(a.Vec2)(),S=Object(a.Vec2)(),x=Object(a.Vec3)(),O=0,w=Object(a.Vec2)(),C=Object(a.Vec2)(),j=0,P=Object(a.Vec2)(),E=Object(a.Vec2)(),A=Object(a.Vec2)(),D=Object(a.Vec2)(),T=Object(a.Vec2)(),I=Object(a.Vec2)(),M=a.Vec3.clone(t.target),k=a.Vec3.clone(t.position),B=a.Vec3.clone(t.up),V=Object(a.Vec2)(),R=Object(a.Vec2)(),L=Object(a.Vec3)(),N=Object(a.Quat)(),F=Object(a.Vec3)(),U=Object(a.Vec3)(),z=Object(a.Vec3)(),H=Object(a.Vec3)(),G=Object(a.Quat)(),q=Object(a.Vec2)(),W=Object(a.Vec3)(),X=Object(a.Vec3)();function Y(t,r){return t*=e.pixelRatio,r*=e.pixelRatio,t>s.x+s.width||e.height-r>s.y+s.height||t<s.x||e.height-r<s.y}var Q=-1;function K(r){var i,o,s,u,c;Q!==r&&(n.spin&&Q>0&&function(e){if(0===n.spinSpeed)return;var t=(n.spinSpeed||0)/1e3;Z[0]=60*Math.min(Math.abs(e),125)/1e3*t,v||a.Vec2.add(S,_,Z)}(r-Q),a.Vec3.sub(y,t.position,t.target),function(){var r=S[0]-_[0],i=S[1]-_[1];a.Vec3.set(H,r,i,0);var o=e.width/e.height,s=a.Vec3.magnitude(H)*n.rotateSpeed*e.pixelRatio*o;s?(a.Vec3.sub(y,t.position,t.target),a.Vec3.normalize(F,y),a.Vec3.normalize(U,t.up),a.Vec3.normalize(z,a.Vec3.cross(z,U,F)),a.Vec3.setMagnitude(U,U,i),a.Vec3.setMagnitude(z,z,r),a.Vec3.add(H,U,z),a.Vec3.normalize(L,a.Vec3.cross(L,H,y)),a.Quat.setAxisAngle(N,L,s),a.Vec3.transformQuat(y,y,N),a.Vec3.transformQuat(t.up,t.up,N),a.Vec3.copy(x,L),O=s):!n.staticMoving&&O&&(O*=Math.sqrt(1-n.dynamicDampingFactor),a.Vec3.sub(y,t.position,t.target),a.Quat.setAxisAngle(N,x,O),a.Vec3.transformQuat(y,y,N),a.Vec3.transformQuat(t.up,t.up,N)),a.Vec2.copy(_,S)}(),i=C[0]-w[0],o=C[1]-w[1],(s=n.rotateSpeed*(-i+o)*-.05)?(a.Vec3.sub(y,t.position,t.target),a.Quat.setAxisAngle(G,y,s),a.Vec3.transformQuat(t.up,t.up,G),j=s):!n.staticMoving&&j&&(j*=Math.sqrt(1-n.dynamicDampingFactor),a.Vec3.sub(y,t.position,t.target),a.Quat.setAxisAngle(G,y,j),a.Vec3.transformQuat(t.up,t.up,G)),a.Vec2.copy(w,C),1!==(u=1+(E[1]-P[1])*n.zoomSpeed)&&u>0&&a.Vec3.scale(y,y,u),n.staticMoving?a.Vec2.copy(P,E):P[1]+=(E[1]-P[1])*n.dynamicDampingFactor,function(){var e=(D[1]-A[1])*n.zoomSpeed;if(0!==e){var r=Math.max(1,t.state.radius+t.state.radius*e);t.setState({radius:r})}n.staticMoving?a.Vec2.copy(A,D):A[1]+=(D[1]-A[1])*n.dynamicDampingFactor}(),function(){if(a.Vec2.sub(q,a.Vec2.copy(q,I),T),a.Vec2.squaredMagnitude(q)){var r=e.pixelRatio*n.panSpeed;q[0]*=1/t.zoom*t.viewport.width*r,q[1]*=1/t.zoom*t.viewport.height*r,a.Vec3.cross(X,a.Vec3.copy(X,y),t.up),a.Vec3.setMagnitude(X,X,q[0]),a.Vec3.setMagnitude(W,t.up,q[1]),a.Vec3.add(X,X,W),a.Vec3.add(t.position,t.position,X),a.Vec3.add(t.target,t.target,X),n.staticMoving?a.Vec2.copy(T,I):(a.Vec2.sub(q,I,T),a.Vec2.scale(q,q,n.dynamicDampingFactor),a.Vec2.add(T,T,q))}}(),a.Vec3.add(t.position,t.target,y),c=Math.min(Math.max(1e3*t.state.radiusMax,.01),n.maxDistance),a.Vec3.squaredMagnitude(y)>c*c&&(a.Vec3.setMagnitude(y,y,c),a.Vec3.add(t.position,t.target,y),a.Vec2.copy(P,E),a.Vec2.copy(A,D)),a.Vec3.squaredMagnitude(y)<n.minDistance*n.minDistance&&(a.Vec3.setMagnitude(y,y,n.minDistance),a.Vec3.add(t.position,t.target,y),a.Vec2.copy(P,E),a.Vec2.copy(A,D)),a.Vec3.squaredDistance(b,t.position)>a.EPSILON&&a.Vec3.copy(b,t.position),Q=r)}var Z=a.Vec2.create(.005,0);return{viewport:s,get props(){return n},setProps:function(e){Object.assign(n,e)},start:function(e){Q=-1,K(e)},update:K,reset:function(){a.Vec3.copy(t.target,M),a.Vec3.copy(t.position,k),a.Vec3.copy(t.up,B),a.Vec3.sub(y,t.position,t.target),a.Vec3.copy(b,t.position)},dispose:function(){d||(d=!0,f.unsubscribe(),h.unsubscribe(),g.unsubscribe(),p.unsubscribe())}}}}(n||(n={}))},function(e,t,r){"use strict";
/*
object-assign
(c) Sindre Sorhus
@license MIT
*/var n=Object.getOwnPropertySymbols,i=Object.prototype.hasOwnProperty,a=Object.prototype.propertyIsEnumerable;function o(e){if(null==e)throw new TypeError("Object.assign cannot be called with null or undefined");return Object(e)}e.exports=function(){try{if(!Object.assign)return!1;var e=new String("abc");if(e[5]="de","5"===Object.getOwnPropertyNames(e)[0])return!1;for(var t={},r=0;r<10;r++)t["_"+String.fromCharCode(r)]=r;if("0123456789"!==Object.getOwnPropertyNames(t).map((function(e){return t[e]})).join(""))return!1;var n={};return"abcdefghijklmnopqrst".split("").forEach((function(e){n[e]=e})),"abcdefghijklmnopqrst"===Object.keys(Object.assign({},n)).join("")}catch(e){return!1}}()?Object.assign:function(e,t){for(var r,s,u=o(e),c=1;c<arguments.length;c++){for(var l in r=Object(arguments[c]))i.call(r,l)&&(u[l]=r[l]);if(n){s=n(r);for(var d=0;d<s.length;d++)a.call(r,s[d])&&(u[s[d]]=r[s[d]])}}return u}},function(e,t,r){"use strict";var n;r.r(t),r.d(t,"PluginSpec",(function(){return n})),function(e){e.Action=function(e,t){return{action:e,customControl:t&&t.customControl,autoUpdate:t&&t.autoUpdate}},e.Behavior=function(e,t){return void 0===t&&(t={}),{transformer:e,defaultParams:t}}}(n||(n={}))},function(e,t,r){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.ModelInfo=t.QueryHelper=t.LigandView=t.PDBeVolumes=void 0;var n=r(0),i=r(27),a=r(10),o=r(13),s=r(4),u=r(308),c=r(169);!function(e){e.mapParams=function(e,t,r){var i=n.__assign({},e);return 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enabled, click on a residue or an atom to view the data.",key:"toast-1",timeoutMs:7e3})},e.toggle=function(e){var t=e.state.data,r=t.select(o.StateSelection.Generators.ofTransformer(u.CreateVolumeStreamingInfo))[0];r&&i.PluginCommands.State.ToggleVisibility(e,{state:t,ref:r.transform.ref})}}(t.PDBeVolumes||(t.PDBeVolumes={})),function(e){e.query=function(e){var t,r={"group-by":a.MolScriptBuilder.core.str.concat([a.MolScriptBuilder.struct.atomProperty.core.operatorName(),a.MolScriptBuilder.struct.atomProperty.macromolecular.residueKey()])};e.auth_seq_id?t=a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.auth_seq_id(),e.auth_seq_id]):e.label_comp_id&&(t=a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.label_comp_id(),e.label_comp_id])),t&&(r["residue-test"]=t),e.auth_asym_id?r["chain-test"]=a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.auth_asym_id(),e.auth_asym_id]):e.struct_asym_id&&(r["chain-test"]=a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.label_asym_id(),e.struct_asym_id]));var n=e.show_all?a.MolScriptBuilder.struct.generator.atomGroups(r):a.MolScriptBuilder.struct.filter.first([a.MolScriptBuilder.struct.generator.atomGroups(r)]);return{core:n,surroundings:a.MolScriptBuilder.struct.modifier.includeSurroundings({0:n,radius:5,"as-whole-residues":!0})}},e.branchedQuery=function(e){var t=[];e.atom_site.forEach((function(e){var r={"group-by":a.MolScriptBuilder.core.str.concat([a.MolScriptBuilder.struct.atomProperty.core.operatorName(),a.MolScriptBuilder.struct.atomProperty.macromolecular.residueKey()]),"residue-test":a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.auth_seq_id(),e.auth_seq_id])};t.push(r)}));var r=[];t.forEach((function(e){r.push(a.MolScriptBuilder.struct.generator.atomGroups(e))}));var n=a.MolScriptBuilder.struct.modifier.union([1===r.length?r[0]:a.MolScriptBuilder.struct.combinator.merge(r.map((function(e){return a.MolScriptBuilder.struct.modifier.union([e])})))]);return{core:n,surroundings:a.MolScriptBuilder.struct.modifier.includeSurroundings({0:n,radius:5,"as-whole-residues":!0})}}}(t.LigandView||(t.LigandView={})),function(e){e.getQueryObject=function(e){var t=[];e.forEach((function(e){var r={};if(e.entity_id&&(r["entity-test"]=a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.label_entity_id(),e.entity_id])),e.struct_asym_id?r["chain-test"]=a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.label_asym_id(),e.struct_asym_id]):e.auth_asym_id&&(r["chain-test"]=a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.auth_asym_id(),e.auth_asym_id])),e.label_comp_id?r["residue-test"]=a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.label_comp_id(),e.label_comp_id]):e.residue_number?r["residue-test"]=a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.label_seq_id(),e.residue_number]):e.start_residue_number&&e.end_residue_number&&e.end_residue_number>e.start_residue_number?r["residue-test"]=a.MolScriptBuilder.core.rel.inRange([a.MolScriptBuilder.struct.atomProperty.macromolecular.label_seq_id(),e.start_residue_number,e.end_residue_number]):e.start_residue_number&&e.end_residue_number&&e.end_residue_number===e.start_residue_number?r["residue-test"]=a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.label_seq_id(),e.start_residue_number]):e.auth_seq_id?r["residue-test"]=a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.auth_seq_id(),e.auth_seq_id]):e.auth_residue_number&&!e.auth_ins_code_id?r["residue-test"]=a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.auth_seq_id(),e.auth_residue_number]):e.auth_residue_number&&e.auth_ins_code_id?r["residue-test"]=a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.authResidueId(),a.MolScriptBuilder.struct.type.authResidueId([void 0,e.auth_residue_number,e.auth_ins_code_id])]):e.start_auth_residue_number&&e.end_auth_residue_number&&e.end_auth_residue_number>e.start_auth_residue_number?e.start_auth_ins_code_id&&e.end_auth_ins_code_id?r["residue-test"]=a.MolScriptBuilder.core.rel.inRange([a.MolScriptBuilder.struct.atomProperty.macromolecular.authResidueId(),a.MolScriptBuilder.struct.type.authResidueId([void 0,e.start_auth_residue_number,e.start_auth_ins_code_id]),a.MolScriptBuilder.struct.type.authResidueId([void 0,e.start_auth_residue_number,e.start_auth_ins_code_id])]):r["residue-test"]=a.MolScriptBuilder.core.rel.inRange([a.MolScriptBuilder.struct.atomProperty.macromolecular.auth_seq_id(),e.start_auth_residue_number,e.end_auth_residue_number]):e.start_auth_residue_number&&e.end_auth_residue_number&&e.end_auth_residue_number===e.start_auth_residue_number&&(e.start_auth_ins_code_id?r["residue-test"]=a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.authResidueId(),a.MolScriptBuilder.struct.type.authResidueId([void 0,e.start_auth_residue_number,e.start_auth_ins_code_id])]):r["residue-test"]=a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.auth_seq_id(),e.start_auth_residue_number])),e.atoms){var n=[];e.atoms.forEach((function(e){n.push(a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.ammp("label_atom_id"),e]))})),r["atom-test"]=a.MolScriptBuilder.core.logic.or(n)}t.push(r)}));var r=[];return t.forEach((function(e){r.push(a.MolScriptBuilder.struct.generator.atomGroups(e))})),a.MolScriptBuilder.struct.modifier.union([1===r.length?r[0]:a.MolScriptBuilder.struct.combinator.merge(r.map((function(e){return a.MolScriptBuilder.struct.modifier.union([e])})))])},e.getInteractivityLoci=function(t,r){var n=c.compile(e.getQueryObject(t))(new s.QueryContext(r));return s.StructureSelection.toLociWithSourceUnits(n)},e.getHetLoci=function(e,t){var r=c.compile(e)(new s.QueryContext(t));return s.StructureSelection.toLociWithSourceUnits(r)}}(t.QueryHelper||(t.QueryHelper={})),function(e){e.get=function(e,t){return n.__awaiter(this,void 0,void 0,(function(){var t,r,i,a,o,s,u,c,l,d;return n.__generator(this,(function(n){for(t=e.atomicHierarchy.residues._rowCount,r=e.atomicHierarchy.residueAtomSegments.offsets,i=e.atomicHierarchy.chainAtomSegments.index,a=[],o=0,s=0;s<t;s++)u=i[r[s]],c=e.atomicHierarchy.index.getEntityFromChain(u),"non-polymer"!==(l=e.entities.data.type.value(c))&&"branched"!==l||(d=e.atomicHierarchy.atoms.label_comp_id.value(r[s]),"branched"===l?o++:-1===a.indexOf(d)&&a.push(d));return[2,{hetNames:a,carbEntityCount:o}]}))}))}}(t.ModelInfo||(t.ModelInfo={}))},function(e,t,r){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.DomainAnnotationsColorThemeProvider=t.DomainAnnotationsColorTheme=t.DomainAnnotationsColorThemeParams=void 0;var n=r(410),i=r(4),a=r(24),o=r(2),s=[a.Color.fromRgb(170,170,170),a.Color.fromRgb(255,112,3)];function u(e,t){var r;if(e.structure&&!e.structure.isEmpty&&e.structure.models[0].customProperties.has(n.DomainAnnotationsProvider.descriptor)){var a=n.DomainAnnotations.getDomains,o=t.type.params.kind;r=function(e){return i.StructureElement.Location.is(e)&&a(e).indexOf(o)>=0?s[1]:s[0]}}else r=function(){return s[0]};return{factory:u,granularity:"group",color:r,props:t,description:"Highlights Sequnece and Structure Domain Annotations. 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0:t.models[0])},ensureCustomProperties:{attach:function(e,t){return t.structure?n.DomainAnnotationsProvider.attach(e,t.structure.models[0],void 0,!0):Promise.resolve()},detach:function(e){return e.structure&&e.structure.models[0].customProperties.reference(n.DomainAnnotationsProvider.descriptor,!1)}}}},function(e,t,r){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.DomainAnnotationsProvider=t.DomainAnnotationsParams=t.DomainAnnotations=void 0;var n,i=r(0),a=r(4),o=r(248),s=r(316),u=r(2),c=r(29),l=r(119),d=r(66);function f(e,t,r,n,i){var a=function(e,t,r){var n=(0,e.entities.getEntityIndex)(t);if(n<0||!e.entity_index_label_asym_id.has(n))return-1;var i=e.entity_index_label_asym_id.get(n);return i&&i.has(r)?i.get(r):-1}(t,r,n);if(a<0)return-1;var o=t.chain_index_auth_seq_id.get(a);return o.has(i)?o.get(i):-1}!function(e){function r(e,t){return t+"/"+e.toLowerCase()}function n(e,t){return{info:o.PropertyWrapper.createInfo(),data:function(e,t){for(var r=[],n=[],i=new 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o=l.Asset.getUrlAsset(e.assetManager,r(t.entryId,a.serverUrl)),[4,e.assetManager.resolve(o,"json").runInContext(e.runtime)];case 1:if(s=i.sent(),!(u=s.data[t.entryId.toLowerCase()]))throw new Error("missing data");return[2,{value:n(t,u),assets:[s]}]}}))}))};var s=[];e.getDomains=function(e){if(!a.Unit.isAtomic(e.unit))return s;var r=t.DomainAnnotationsProvider.get(e.unit.model).value;if(!r||!r.data)return s;var n=e.unit.residueIndex[e.element];return r.data.domains.has(n)?r.data.domains.get(n):s},e.getDomainTypes=function(e){if(!e)return s;var r=t.DomainAnnotationsProvider.get(e.models[0]).value;return r&&r.data?r.data.domainTypes:s},e.getDomainNames=function(e){if(!e)return s;var r=t.DomainAnnotationsProvider.get(e.models[0]).value;return r&&r.data?r.data.domainNames:s}}(n||(n={})),t.DomainAnnotations=n,t.DomainAnnotationsParams={serverUrl:u.ParamDefinition.Text(n.DefaultServerUrl,{description:"JSON API Server URL"})},t.DomainAnnotationsProvider=s.CustomModelProperty.createProvider({label:"Domain annotations",descriptor:d.CustomPropertyDescriptor({name:"domain_annotations"}),type:"static",defaultParams:t.DomainAnnotationsParams,getParams:function(e){return t.DomainAnnotationsParams},isApplicable:function(e){return n.isApplicable(e)},obtain:function(e,r,a){return i.__awaiter(void 0,void 0,void 0,(function(){var o;return i.__generator(this,(function(s){switch(s.label){case 0:return o=i.__assign(i.__assign({},u.ParamDefinition.getDefaultValues(t.DomainAnnotationsParams)),a),[4,n.fromServer(e,r,o)];case 1:return[2,s.sent()]}}))}))}})},function(e,t,r){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.PDBeDomainAnnotations=void 0;var n=r(0),i=r(410),a=r(409),o=r(2),s=r(177);t.PDBeDomainAnnotations=s.PluginBehavior.create({name:"pdbe-domain-annotations-prop",category:"custom-props",display:{name:"Domain annotations",description:"Data for domain annotations, obtained via PDBe."},ctor:function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.provider=i.DomainAnnotationsProvider,t.labelDomainAnnotations={label:function(e){}},t}return n.__extends(t,e),t.prototype.register=function(){this.ctx.customModelProperties.register(this.provider,this.params.autoAttach),this.ctx.managers.lociLabels.addProvider(this.labelDomainAnnotations),this.ctx.representation.structure.themes.colorThemeRegistry.add(a.DomainAnnotationsColorThemeProvider)},t.prototype.update=function(e){var t=this.params.autoAttach!==e.autoAttach;return this.params.autoAttach=e.autoAttach,this.params.showTooltip=e.showTooltip,this.ctx.customModelProperties.setDefaultAutoAttach(this.provider.descriptor.name,this.params.autoAttach),t},t.prototype.unregister=function(){this.ctx.customModelProperties.unregister(i.DomainAnnotationsProvider.descriptor.name),this.ctx.managers.lociLabels.removeProvider(this.labelDomainAnnotations),this.ctx.representation.structure.themes.colorThemeRegistry.remove(a.DomainAnnotationsColorThemeProvider)},t}(s.PluginBehavior.Handler),params:function(){return{autoAttach:o.ParamDefinition.Boolean(!1),showTooltip:o.ParamDefinition.Boolean(!0)}}})},function(e,t,r){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.renderSuperposition=t.initSuperposition=void 0;var n=r(0),i=r(1),a=r(10),o=r(31),s=r(119),u=r(408),c=r(100),l=r(46),d=r(126);function f(e,t){var r=c.ColorLists,n=e.customState.superpositionState,i=n.colorState[t].palleteIndex,a=n.colorState[t].colorIndex;r[n.colorPalette[i]].list[a+1]?a+=1:(a=0,i=n.colorPalette[i+1]?i+1:0);var o=n.colorPalette[i];return e.customState.superpositionState.colorState[t].palleteIndex=i,e.customState.superpositionState.colorState[t].colorIndex=a,r[o].list[a]}function p(e,t,r){return n.__awaiter(this,void 0,void 0,(function(){var o,s,u,c=this;return n.__generator(this,(function(p){return o=e.customState,s=o.initParams.superpositionParams,u=!1,r.length>1&&(u=!0,o.events.isBusy.next(!0)),[2,e.dataTransaction((function(){return n.__awaiter(c,void 0,void 0,(function(){var c,p,v,b,y,S,x,O,w,C,j,P,E,A,D,T,I,M,k,B,V,R,L,N,F,U,z,H,G,q,W,X,Y,Q,K,Z,J,$,ee,te,re,ne,ie,ae,oe,se,ue,ce,le,de,fe,pe,me,he,ge,ve,be,ye;return n.__generator(this,(function(_e){switch(_e.label){case 0:c=e.customState.superpositionState,_e.label=1;case 1:_e.trys.push([1,41,42,47]),p=n.__asyncValues(r),_e.label=2;case 2:return[4,p.next()];case 3:return(v=_e.sent()).done?[3,40]:(b=v.value,c.matrixData[b.pdb_id+"_"+b.auth_asym_id]?(c.loadedStructs[t].push(b.pdb_id+"_"+b.struct_asym_id),y=o.initParams.pdbeUrl+"model-server/v1/"+b.pdb_id+"/atoms?auth_asym_id="+b.auth_asym_id+"&encoding="+o.initParams.encoding,s&&s.ligandView&&(y="https://www.ebi.ac.uk/pdbe/entry-files/download/"+b.pdb_id+".bcif"),S=void 0,x=void 0,!0,s&&s.ligandView&&c.entries[b.pdb_id]?(O=e.state.data.select(c.entries[b.pdb_id])[0],x=O.transform.parent,w=e.state.data.select(x)[0],[4,e.builders.structure.createStructure(w,{name:"model",params:{}})]):[3,5]):(c.noMatrixStruct.push(b.pdb_id+"_"+b.struct_asym_id),c.invalidStruct.push(b.pdb_id+"_"+b.struct_asym_id),[3,39]));case 4:return S=_e.sent(),!1,[3,7];case 5:return C="bcif"===o.initParams.encoding,[4,h(e,y,"mmcif",C)];case 6:j=_e.sent(),P=j.model,E=j.structure,S=E,x=P.ref,_e.label=7;case 7:return S?(c.models[b.pdb_id+"_"+b.struct_asym_id]||(c.models[b.pdb_id+"_"+b.struct_asym_id]=null==S?void 0:S.ref),s&&s.ligandView&&!c.entries[b.pdb_id]&&(c.entries[b.pdb_id]=null==S?void 0:S.ref),A=i.Mat4.ofRows(e.customState.superpositionState.matrixData[b.pdb_id+"_"+b.auth_asym_id].matrix),[4,g(e,S,A)]):[3,39];case 8:return _e.sent(),D=void 0,s&&s.ligandView&&b.is_representative?(T=f(e,t),[4,e.builders.structure.tryCreateComponentFromExpression(S,(Se=b.struct_asym_id,a.MolScriptBuilder.struct.generator.atomGroups({"chain-test":a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.label_asym_id(),Se])})),"Chain-"+t,{label:"Chain",tags:["superposition-sel"]})]):[3,12];case 9:return(D=_e.sent())?[4,e.builders.structure.representation.addRepresentation(D,{type:"putty",color:"uniform",colorParams:{value:T},size:"uniform"},{tag:"superposition-visual"})]:[3,11];case 10:_e.sent(),c.refMaps[D.ref]=b.pdb_id+"_"+b.struct_asym_id,_e.label=11;case 11:return[3,16];case 12:return s&&s.ligandView&&!b.is_representative?[3,16]:[3,13];case 13:return I=f(e,t),[4,e.builders.structure.tryCreateComponentStatic(S,"polymer",{label:"Chain",tags:["Chain-"+t,"superposition-sel"]})];case 14:return(D=_e.sent())?[4,e.builders.structure.representation.addRepresentation(D,{type:"putty",color:"uniform",colorParams:{value:I},size:"uniform"},{tag:"superposition-visual"})]:[3,16];case 15:_e.sent(),c.refMaps[D.ref]=b.pdb_id+"_"+b.struct_asym_id,_e.label=16;case 16:return M=!D,s&&s.ligandView?(k=e.state.data,[4,m(e,k,x)]):[3,39];case 17:if(B=_e.sent(),!((V=B?B.hetNames:[])&&V.length>0))return[3,31];_e.label=18;case 18:_e.trys.push([18,25,26,31]),be=void 0,R=n.__asyncValues(V),_e.label=19;case 19:return[4,R.next()];case 20:return(L=_e.sent()).done?[3,24]:(N=L.value,F=a.MolScriptBuilder.struct.generator.atomGroups({"chain-test":a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.auth_asym_id(),b.auth_asym_id]),"residue-test":a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.label_comp_id(),N]),"group-by":a.MolScriptBuilder.core.str.concat([a.MolScriptBuilder.struct.atomProperty.core.operatorName(),a.MolScriptBuilder.struct.atomProperty.macromolecular.residueKey()])}),fe={label:""+N,tags:["superposition-ligand-sel"]},U=l.Color.fromRgb(253,3,253),s&&s.ligandColor&&(z=s.ligandColor,H=z.r,G=z.g,q=z.b,U=l.Color.fromRgb(H,G,q)),[4,e.builders.structure.tryCreateComponentFromExpression(S,F,N+"-"+t,fe)]);case 21:return(pe=_e.sent())?[4,e.builders.structure.representation.addRepresentation(pe,{type:"ball-and-stick",color:"uniform",colorParams:{value:U}},{tag:"superposition-ligand-visual"})]:[3,23];case 22:_e.sent(),c.refMaps[pe.ref]=b.pdb_id+"_"+b.struct_asym_id,M=!1,_e.label=23;case 23:return[3,19];case 24:return[3,31];case 25:return W=_e.sent(),be={error:W},[3,31];case 26:return _e.trys.push([26,,29,30]),L&&!L.done&&(ye=R.return)?[4,ye.call(R)]:[3,28];case 27:_e.sent(),_e.label=28;case 28:return[3,30];case 29:if(be)throw be.error;return[7];case 30:return[7];case 31:return(B?B.carbEntityCount:0)>0?[4,_(e,b.pdb_id)]:[3,38];case 32:X=_e.sent(),Y=a.MolScriptBuilder.struct.modifier.includeSurroundings({0:a.MolScriptBuilder.struct.generator.atomGroups({"entity-test":a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.ammp("entityType"),"polymer"]),"chain-test":a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.auth_asym_id(),b.auth_asym_id]),"group-by":a.MolScriptBuilder.core.str.concat([a.MolScriptBuilder.struct.atomProperty.core.operatorName(),a.MolScriptBuilder.struct.atomProperty.macromolecular.residueKey()])}),radius:5,"as-whole-residues":!0}),Q=0,K=0,Z=X.branchedChains,_e.label=33;case 33:if(!(K<Z.length))return[3,38];if(J=Z[K],$=a.MolScriptBuilder.struct.generator.atomGroups({"entity-test":a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.ammp("entityType"),"branched"]),"chain-test":a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.auth_asym_id(),J]),"group-by":a.MolScriptBuilder.core.str.concat([a.MolScriptBuilder.struct.atomProperty.core.operatorName(),a.MolScriptBuilder.struct.atomProperty.macromolecular.residueKey()])}),ee=a.MolScriptBuilder.struct.filter.intersectedBy({0:Y,by:$}),te=e.state.data.select(S.ref)[0].obj.data,!(re=d.Script.getStructureSelection(ee,te))||"sequence"!==re.kind)return[3,36];for(ne=[],ie={},ae=[],oe=0,se=X.branchedLigands[Q];oe<se.length;oe++)ue=se[oe],ce=ue.split("-"),ne.push(a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.auth_seq_id(),+ce[1]])),ie[ce[0]]?ie[ce[0]]++:ie[ce[0]]=1,ae.push(ce[0]);return le=function(e){var t=[];for(var r in e)t.push(r+" ("+e[r]+")");return t.join(", ")}(ie),de=a.MolScriptBuilder.struct.generator.atomGroups({"entity-test":a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.ammp("entityType"),"branched"]),"group-by":a.MolScriptBuilder.core.str.concat([a.MolScriptBuilder.struct.atomProperty.core.operatorName(),a.MolScriptBuilder.struct.atomProperty.macromolecular.residueKey()]),"chain-test":a.MolScriptBuilder.core.rel.eq([a.MolScriptBuilder.struct.atomProperty.macromolecular.auth_asym_id(),J]),"residue-test":a.MolScriptBuilder.core.logic.or(ne)}),fe={label:""+le,tags:["superposition-carb-sel"]},[4,e.builders.structure.tryCreateComponentFromExpression(S,de,ae.join("-")+"-"+t,fe)];case 34:return(pe=_e.sent())?[4,e.builders.structure.representation.addRepresentation(pe,{type:"carbohydrate"},{tag:"superposition-carb-visual"})]:[3,36];case 35:_e.sent(),c.refMaps[pe.ref]=b.pdb_id+"_"+b.struct_asym_id,M=!1,_e.label=36;case 36:Q++,_e.label=37;case 37:return K++,[3,33];case 38:M&&(c.invalidStruct.push(b.pdb_id+"_"+b.struct_asym_id),(me=c.loadedStructs[t].indexOf(b.pdb_id+"_"+b.struct_asym_id))>-1&&c.loadedStructs[t].splice(me,1)),_e.label=39;case 39:return[3,2];case 40:return[3,47];case 41:return he=_e.sent(),ge={error:he},[3,47];case 42:return _e.trys.push([42,,45,46]),v&&!v.done&&(ve=p.return)?[4,ve.call(p)]:[3,44];case 43:_e.sent(),_e.label=44;case 44:return[3,46];case 45:if(ge)throw ge.error;return[7];case 46:return[7];case 47:return u&&(u=!1,o.events.isBusy.next(!1)),[2]}var Se}))}))}))]}))}))}function m(e,t,r){var i;return n.__awaiter(this,void 0,void 0,(function(){var a,o,s,c,l,d,f;return n.__generator(this,(function(n){switch(n.label){case 0:if(!(a=t.select(r)[0])||!a.obj)return[2,void 0];if(!(o=a.obj.data))return[2];for(s=[],c=0,l=e.managers.structure.hierarchy.selection.structures;c<l.length;c++)d=l[c],(f=null===(i=d.cell.obj)||void 0===i?void 0:i.data)&&s.push(f);return[4,u.ModelInfo.get(o,s)];case 1:return[2,n.sent()]}}))}))}function h(e,t,r,i){return n.__awaiter(this,void 0,void 0,(function(){var a,o,u,c;return n.__generator(this,(function(n){switch(n.label){case 0:return n.trys.push([0,5,,6]),[4,e.builders.data.download({url:s.Asset.Url(t),isBinary:i})];case 1:return a=n.sent(),[4,e.builders.structure.parseTrajectory(a,r)];case 2:return o=n.sent(),[4,e.builders.structure.createModel(o)];case 3:return u=n.sent(),[4,e.builders.structure.createStructure(u,{name:"model",params:{}})];case 4:return c=n.sent(),[2,{data:a,trajectory:o,model:u,structure:c}];case 5:return n.sent(),[2,{structure:void 0}];case 6:return[2]}}))}))}function g(e,t,r){var n=e.state.data.build().to(t).insert(o.StateTransforms.Model.TransformStructureConformation,{transform:{name:"matrix",params:{data:r,transpose:!1}}});return e.runTask(e.state.data.updateTree(n))}function v(e){return n.__awaiter(this,void 0,void 0,(function(){var t,r,i,a,o,u;return n.__generator(this,(function(n){switch(n.label){case 0:t=e.customState,r=t.initParams.superpositionParams.matrixAccession?t.initParams.superpositionParams.matrixAccession:t.initParams.moleculeId,i=t.initParams.pdbeUrl+"static/superpose/matrices/"+r,a=e.managers.asset,o=s.Asset.getUrlAsset(a,i),n.label=1;case 1:return n.trys.push([1,3,,4]),[4,e.runTask(a.resolve(o,"json",!1))];case 2:return(u=n.sent())&&u.data&&(e.customState.superpositionState.matrixData=u.data),[3,4];case 3:return n.sent(),t.superpositionError="Matrix data not available for "+r,e.customState.events.superpositionInit.next(!0),[3,4];case 4:return[2]}}))}))}function b(e){return n.__awaiter(this,void 0,void 0,(function(){var t,r,i,a,o;return n.__generator(this,(function(n){switch(n.label){case 0:t=e.customState,r=t.initParams.pdbeUrl+"graph-api/uniprot/superposition/"+t.initParams.moleculeId,i=e.managers.asset,a=s.Asset.getUrlAsset(i,r),n.label=1;case 1:return n.trys.push([1,3,,4]),[4,e.runTask(i.resolve(a,"json",!1))];case 2:return(o=n.sent())&&o.data&&(t.superpositionState.segmentData=o.data[t.initParams.moleculeId]),[3,4];case 3:return n.sent(),t.superpositionError="Superposition data not available for "+t.initParams.moleculeId,e.customState.events.superpositionInit.next(!0),[3,4];case 4:return[2]}}))}))}function y(e){for(var t,r=[],n=[],i=[],a=[],o=0,s=e.chem_comp_list;o<s.length;o++){var u=s[o];a.push(u.chem_comp_id+" ("+u.count+")")}t=a.join(", ");for(var c=0,l=e.chains;c<l.length;c++){var d=l[c];r.push(d.chain_id),n.push(t);for(var f=[],p=0,m=d.residues;p<m.length;p++){var h=m[p];f.push(h.chem_comp_id+"-"+h.residue_number)}i.push(f)}return{ligands:i,ligandChain:r,ligandLabels:n}}function _(e,t){return n.__awaiter(this,void 0,void 0,(function(){var r,i,a,o,u,c,l,d,f,p,m,h,g;return n.__generator(this,(function(n){switch(n.label){case 0:r=e.customState,i=r.initParams.pdbeUrl+"api/pdb/entry/carbohydrate_polymer/"+t,a=e.managers.asset,o=s.Asset.getUrlAsset(a,i),u=[],c=[],l=[],n.label=1;case 1:return n.trys.push([1,3,,4]),[4,e.runTask(a.resolve(o,"json",!1))];case 2:if((d=n.sent())&&d.data)for(f=d.data[t],p=0,m=f;p<m.length;p++)h=m[p],g=y(h),u=u.concat(g.ligands),c=c.concat(g.ligandChain),l=l.concat(g.ligandLabels);return[3,4];case 3:return n.sent(),[3,4];case 4:return[2,{branchedChains:c,branchedLigands:u,branchedlabels:l}]}}))}))}t.initSuperposition=function(e){return n.__awaiter(this,void 0,void 0,(function(){var t,r,i,a,o,s;return n.__generator(this,(function(n){switch(n.label){case 0:return[4,e.clear()];case 1:return n.sent(),t=e.customState,r=t.initParams.superpositionParams,e.customState.superpositionState={models:{},entries:{},refMaps:{},segmentData:void 0,matrixData:{},activeSegment:0,loadedStructs:[],visibleRefs:[],invalidStruct:[],noMatrixStruct:[],hets:{},colorPalette:["dark-2","red-yellow-green","paired","set-1","accent","set-2","rainbow"],colorState:[]},[4,b(e)];case 2:return n.sent(),(i=e.customState.superpositionState.segmentData)?[4,v(e)]:[2];case 3:return n.sent(),e.customState.superpositionState.segmentData?(i.forEach((function(){e.customState.superpositionState.loadedStructs.push([]),e.customState.superpositionState.visibleRefs.push([]),e.customState.superpositionState.colorState.push({palleteIndex:0,colorIndex:-1})})),a=r&&r.segment?r.segment-1:0,e.customState.superpositionState.activeSegment=a+1,o=r&&r.cluster?r.cluster:void 0,e.customState.events.superpositionInit.next(!0),s=[],i[a].clusters.forEach((function(e,t){o&&-1===o.indexOf(t)||(r&&r.superposeAll?s=s.concat(e):s.push(e[0]))})),[4,p(e,a,s)]):[2];case 4:return n.sent(),[2]}}))}))},t.renderSuperposition=p},function(e,t,r){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t._bundleLabel=t.bondLabel=t.lociDetails=void 0;var n=r(0),i=r(4),a=r(6);function o(e){switch(e.kind){case"structure-loci":return{models:e.structure.models.map((function(e){return e.entry})).filter((function(e){return!!e}))};case"element-loci":return r=i.StructureElement.Stats.ofLoci(e),n=r.chainCount,a=r.residueCount,1===(o=r.elementCount)&&0===a&&0===n?s(r.firstElementLoc,"element"):0===o&&1===a&&0===n?s(r.firstResidueLoc,"residue"):void 0;case"bond-loci":var t=e.bonds[0];return t?u(t,"element"):"";default:return}var r,n,a,o}function s(e,t){void 0===t&&(t="element");var r,a={},o=e.unit.model.entry;return o.length>30&&(o=o.substr(0,27)+"…"),a.entry_id=o,"structure"!==t&&(a.model=e.unit.model.modelNum,a.instance=e.unit.conformation.operator.name),i.Unit.isAtomic(e.unit)?r=function(e,t){var r={entity_id:i.StructureProperties.chain.label_entity_id(e),label_asym_id:i.StructureProperties.chain.label_asym_id(e),auth_asym_id:i.StructureProperties.chain.auth_asym_id(e),seq_id:i.StructureProperties.residue.label_seq_id(e),auth_seq_id:i.StructureProperties.residue.auth_seq_id(e),ins_code:i.StructureProperties.residue.pdbx_PDB_ins_code(e),comp_id:i.StructureProperties.atom.label_comp_id(e),atom_id:[i.StructureProperties.atom.label_atom_id(e)],alt_id:i.StructureProperties.atom.label_alt_id(e)},n=i.StructureProperties.residue.microheterogeneityCompIds(e);return r.micro_het_comp_ids="residue"===t&&n.length>1?n:[r.comp_id],r}(e,t):i.Unit.isCoarse(e.unit)&&(r=function(e,t){var r={asym_id:i.StructureProperties.coarse.asym_id(e),seq_id_begin:i.StructureProperties.coarse.seq_id_begin(e),seq_id_end:i.StructureProperties.coarse.seq_id_end(e)};if("residue"===t&&r.seq_id_begin===r.seq_id_end){var n=i.StructureProperties.coarse.entityKey(e),a=e.unit.model.sequence.byEntityKey[n];r.comp_id=a.sequence.compId.value(r.seq_id_begin-1)}return r}(e,t)),n.__assign(n.__assign({},a),r)}function u(e,t){return c({loci:[i.StructureElement.Loci(e.aStructure,[{unit:e.aUnit,indices:a.OrderedSet.ofSingleton(e.aIndex)}]),i.StructureElement.Loci(e.bStructure,[{unit:e.bUnit,indices:a.OrderedSet.ofSingleton(e.bIndex)}])]},t)}function c(e,t){for(var r=!0,n=0,u=e.loci;n<u.length;n++){var c=u[n];if(!i.StructureElement.Loci.is(c)||1!==i.StructureElement.Loci.size(c)){r=!1;break}}if(r){var l,d=e.loci.map((function(e){var t=e.elements[0],r=t.unit,n=t.indices;return i.StructureElement.Location.create(e.structure,r,r.elements[a.OrderedSet.start(n)])})).map((function(e){return s(e,t)})),f=[d[0].atom_id[0],d[1].atom_id[0]];return(l=d[0]).atom_id=f,l}return l=e.loci.map((function(e){return o(e)}))}t.lociDetails=o,t.bondLabel=u,t._bundleLabel=c},function(e,t,r){"use strict";r.d(t,"a",(function(){return s}));var n=r(41),i=r(90),a=r(186),o=r(1),s=function(){function e(e,t,r,o,s){var u=this;void 0===s&&(s=30),this.canvasIdentify=e,this.getLoci=t,this.input=r,this.camera=o,this.maxFps=s,this.ev=a.RxEventHelper.create(),this.events={hover:this.ev(),drag:this.ev(),click:this.ev()},this.startX=-1,this.startY=-1,this.endX=-1,this.endY=-1,this.id=void 0,this.position=void 0,this.currentIdentifyT=0,this.isInteracting=!1,this.prevLoci=n.a.Loci.Empty,this.prevT=0,this.inside=!1,this.buttons=i.a.create(0),this.button=i.a.create(0),this.modifiers=i.b.None,r.drag.subscribe((function(e){var t=e.x,r=e.y,n=e.buttons,i=e.button,a=e.modifiers;u.isInteracting=!0,u.drag(t,r,n,i,a)})),r.move.subscribe((function(e){var t=e.x,r=e.y,n=e.inside,i=e.buttons,a=e.button,o=e.modifiers;n&&!u.isInteracting&&u.move(t,r,i,a,o)})),r.leave.subscribe((function(){u.leave()})),r.click.subscribe((function(e){var t=e.x,r=e.y,n=e.buttons,i=e.button,a=e.modifiers;u.outsideViewport(t,r)||u.click(t,r,n,i,a)})),r.interactionEnd.subscribe((function(){u.isInteracting=!1})),r.modifiers.subscribe((function(e){u.modify(e)}))}return e.prototype.identify=function(e,t){var r=this.startX!==this.endX||this.startY!==this.endY;if(2!==e){if(r){var i=this.canvasIdentify(this.endX,this.endY);this.id=null==i?void 0:i.id,this.position=null==i?void 0:i.position,this.startX=this.endX,this.startY=this.endY}if(1===e){var a=this.getLoci(this.id);return this.events.click.next({current:a,buttons:this.buttons,button:this.button,modifiers:this.modifiers,page:o.Vec2.create(this.endX,this.endY),position:this.position}),void(this.prevLoci=a)}if(this.inside&&this.currentIdentifyT===t&&r&&!this.outsideViewport(this.endX,this.endY)){var s=this.getLoci(this.id);this.events.hover.next({current:s,buttons:this.buttons,button:this.button,modifiers:this.modifiers,page:o.Vec2.create(this.endX,this.endY),position:this.position}),this.prevLoci=s}}else r&&!n.a.Loci.isEmpty(this.prevLoci)&&(this.events.drag.next({current:this.prevLoci,buttons:this.buttons,button:this.button,modifiers:this.modifiers,pageStart:o.Vec2.create(this.startX,this.startY),pageEnd:o.Vec2.create(this.endX,this.endY)}),this.startX=this.endX,this.startY=this.endY)},e.prototype.tick=function(e){this.inside&&e-this.prevT>1e3/this.maxFps&&(this.prevT=e,this.currentIdentifyT=e,this.identify(this.isInteracting?2:0,e))},e.prototype.leave=function(){this.inside=!1,n.a.Loci.isEmpty(this.prevLoci)||(this.prevLoci=n.a.Loci.Empty,this.events.hover.next({current:this.prevLoci,buttons:this.buttons,button:this.button,modifiers:this.modifiers}))},e.prototype.move=function(e,t,r,n,i){this.inside=!0,this.buttons=r,this.button=n,this.modifiers=i,this.endX=e,this.endY=t},e.prototype.click=function(e,t,r,n,i){this.endX=e,this.endY=t,this.buttons=r,this.button=n,this.modifiers=i,this.identify(1,0)},e.prototype.drag=function(e,t,r,n,i){this.endX=e,this.endY=t,this.buttons=r,this.button=n,this.modifiers=i,this.identify(2,0)},e.prototype.modify=function(e){i.b.areEqual(e,this.modifiers)||(this.modifiers=e,this.events.hover.next({current:this.prevLoci,buttons:this.buttons,button:this.button,modifiers:this.modifiers,page:o.Vec2.create(this.endX,this.endY),position:this.position}))},e.prototype.outsideViewport=function(e,t){var r=this.input,n=this.camera.viewport;return e*=r.pixelRatio,t*=r.pixelRatio,e>n.x+n.width||r.height-t>n.y+n.height||e<n.x||r.height-t<n.y},e.prototype.dispose=function(){this.ev.dispose()},e}()},function(e,t,r){"use strict";r.d(t,"a",(function(){return p}));var n=r(0),i=r(2),a=r(391),o=r(174),s=r(228),u=r(172),c=r(105),l=r(334),d=r(242),f={transparentBackground:i.ParamDefinition.Boolean(!1),multiSample:i.ParamDefinition.Group(s.b),postprocessing:i.ParamDefinition.Group(o.b),cameraHelper:i.ParamDefinition.Group(d.b)},p=function(){function e(e,t,r,o,c,l,p){this.webgl=e,this.renderer=t,this.scene=r,this.camera=o,this._width=0,this._height=0,this._camera=new u.a,this.props=Object(n.__assign)(Object(n.__assign)({},i.ParamDefinition.getDefaultValues(f)),p),this.drawPass=new a.a(e,128,128,l),this.multiSamplePass=new s.c(e,this.drawPass),this.multiSampleHelper=new s.a(this.multiSamplePass),this.helper={camera:new d.a(e,this.props.cameraHelper),debug:c.debug,handle:c.handle},this.setSize(1024,768)}return Object.defineProperty(e.prototype,"colorTarget",{get:function(){return this._colorTarget},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"width",{get:function(){return this._width},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"height",{get:function(){return this._height},enumerable:!1,configurable:!0}),e.prototype.setSize=function(e,t){e===this._width&&t===this._height||(this._width=e,this._height=t,this.drawPass.setSize(e,t),this.multiSamplePass.syncSize())},e.prototype.setProps=function(e){void 0===e&&(e={}),Object.assign(this.props,e),e.cameraHelper&&this.helper.camera.setProps(e.cameraHelper)},e.prototype.render=function(){u.a.copySnapshot(this._camera.state,this.camera.state),c.a.set(this._camera.viewport,0,0,this._width,this._height),this._camera.update(),s.c.isEnabled(this.props.multiSample)?(this.multiSampleHelper.render(this.renderer,this._camera,this.scene,this.helper,!1,this.props.transparentBackground,this.props),this._colorTarget=this.multiSamplePass.colorTarget):(this.drawPass.render(this.renderer,this._camera,this.scene,this.helper,!1,this.props.transparentBackground,this.props.postprocessing),this._colorTarget=this.drawPass.getColorTarget(this.props.postprocessing))},e.prototype.getImageData=function(e,t,r){var n,i;this.setSize(e,t),this.render(),this.colorTarget.bind();var a=null!==(n=null==r?void 0:r.width)&&void 0!==n?n:e,o=null!==(i=null==r?void 0:r.height)&&void 0!==i?i:t,s=new Uint8Array(a*o*4);return r?this.webgl.readPixels(r.x,t-r.y-r.height,a,o,s):this.webgl.readPixels(0,0,a,o,s),l.a.flipY({array:s,width:a,height:o}),new ImageData(new Uint8ClampedArray(s),a,o)},e}()},function(e,t,r){"use strict";r.d(t,"a",(function(){return l}));var n=r(0),i=r(2),a=r(339),o=r(242),s=r(340),u={debug:i.ParamDefinition.Group(a.b),camera:i.ParamDefinition.Group({helper:i.ParamDefinition.Group(o.b)}),handle:i.ParamDefinition.Group(s.b)},c=i.ParamDefinition.getDefaultValues(u),l=function(e,t,r){void 0===r&&(r={});var i=Object(n.__assign)(Object(n.__assign)({},c),r);this.debug=new a.a(e,t,i.debug),this.camera=new o.a(e,i.camera.helper),this.handle=new s.a(e,i.handle)}},function(e,t,r){"use strict";r.d(t,"a",(function(){return o}));var n=r(391),i=r(376),a=r(228),o=function(){function e(e,t){void 0===t&&(t={}),this.webgl=e;var r=e.gl;this.draw=new n.a(e,r.drawingBufferWidth,r.drawingBufferHeight,t.enableWboit||!1),this.pick=new i.b(e,this.draw,t.pickScale||.25),this.multiSample=new a.c(e,this.draw)}return e.prototype.updateSize=function(){var e=this.webgl.gl;this.draw.setSize(e.drawingBufferWidth,e.drawingBufferHeight),this.pick.syncSize(),this.multiSample.syncSize()},e}()},function(e,t,r){"use strict";Object.defineProperty(t,"__esModule",{value:!0});var n=r(0),i=r(419),a=r(27),o=r(13),s=r(23),u=r(186),c=r(408),l=r(434),d=r(437),f=r(13),p=r(327),m=r(407),h=r(308),g=r(167),v=r(439),b=r(440),y=r(412),_=r(442),S=r(119),x=r(78),O=r(46),w=r(260),C=r(2),j=r(411),P=r(448),E=r(449),A=r(378),D=r(397),T=r(443),I=r(444);r(445),D.ElementSymbolColorThemeParams.carbonColor.defaultValue={name:"element-symbol",params:{}};var M=function(){function e(){var e=this;this.assemblyRef="",this.isHighlightColorUpdated=!1,this.isSelectedColorUpdated=!1,this.canvas={toggleControls:function(t){void 0===t&&(t=!e.plugin.layout.state.showControls),a.PluginCommands.Layout.Update(e.plugin,{state:{showControls:t}})},toggleExpanded:function(t){void 0===t&&(t=!e.plugin.layout.state.isExpanded),a.PluginCommands.Layout.Update(e.plugin,{state:{isExpanded:t}})},setBgColor:function(t){if(t){var r=e.plugin.canvas3d.props.renderer;a.PluginCommands.Canvas3D.SetSettings(e.plugin,{settings:{renderer:n.__assign(n.__assign({},r),{backgroundColor:O.Color.fromRgb(t.r,t.g,t.b)})}})}}},this.visual={highlight:function(t){var r=e.getLociForParams(t.data);s.Loci.isEmpty(r)||(t.color&&e.visual.setColor({highlight:t.color}),e.plugin.managers.interactivity.lociHighlights.highlightOnly({loci:r}),t.focus&&e.plugin.managers.camera.focusLoci(r))},clearHighlight:function(){return n.__awaiter(e,void 0,void 0,(function(){return n.__generator(this,(function(e){return this.plugin.managers.interactivity.lociHighlights.highlightOnly({loci:s.EmptyLoci}),this.isHighlightColorUpdated&&this.visual.reset({highlightColor:!0}),[2]}))}))},select:function(t){return n.__awaiter(e,void 0,void 0,(function(){var e,r,i,a,o,u,c,l,d,f,p,m,h,g,v,b,y,_,S,x,j,P,E,A;return n.__generator(this,(function(D){switch(D.label){case 0:return this.selectedParams?[4,this.visual.clearSelection()]:[3,2];case 1:D.sent(),D.label=2;case 2:if(!t.nonSelectedColor)return[3,15];D.label=3;case 3:D.trys.push([3,9,10,15]),e=n.__asyncValues(this.plugin.managers.structure.hierarchy.current.structures),D.label=4;case 4:return[4,e.next()];case 5:return(r=D.sent()).done?[3,8]:(i=r.value,[4,this.plugin.managers.structure.component.updateRepresentationsTheme(i.components,{color:"uniform",colorParams:{value:this.normalizeColor(t.nonSelectedColor)}})]);case 6:D.sent(),D.label=7;case 7:return[3,4];case 8:return[3,15];case 9:return a=D.sent(),j={error:a},[3,15];case 10:return D.trys.push([10,,13,14]),r&&!r.done&&(P=e.return)?[4,P.call(e)]:[3,12];case 11:D.sent(),D.label=12;case 12:return[3,14];case 13:if(j)throw j.error;return[7];case 14:return[7];case 15:D.trys.push([15,23,24,29]),o=n.__asyncValues(t.data),D.label=16;case 16:return[4,o.next()];case 17:return(u=D.sent()).done?[3,22]:(c=u.value,l=this.getLociForParams([c]),s.Loci.isEmpty(l)?[2]:(this.visual.setColor({select:c.color?c.color:{r:255,g:112,b:3}}),this.plugin.managers.interactivity.lociSelects.selectOnly({loci:l}),d=w.StructureComponentManager.getThemeParams(this.plugin,this.plugin.managers.structure.component.pivotStructure),(f=C.ParamDefinition.getDefaultValues(d)).action.params={color:c.color?this.normalizeColor(c.color):O.Color.fromRgb(255,112,3),opacity:1},[4,this.plugin.managers.structure.component.applyTheme(f,this.plugin.managers.structure.hierarchy.current.structures)]));case 18:return D.sent(),c.sideChain||c.representation?(p="ball-and-stick",c.representation&&(p=c.representation),m=w.StructureComponentManager.getAddParams(this.plugin,{allowNone:!1,hideSelection:!0,checkExisting:!0}),(h=C.ParamDefinition.getDefaultValues(m)).options={label:"selection-by-script",checkExisting:!0},g=n.__assign(n.__assign({},h),{representation:p}),v=this.plugin.managers.structure.hierarchy.getStructuresWithSelection(),[4,this.plugin.managers.structure.component.add(g,v)]):[3,20];case 19:D.sent(),c.representationColor&&(b=this.plugin.managers.structure.hierarchy.current.structures[0].components,y=b.length-1,_=[b[y]],S=c.representationColor?this.normalizeColor(c.representationColor):O.Color.fromRgb(255,112,3),this.plugin.managers.structure.component.updateRepresentationsTheme(_,{color:"uniform",colorParams:{value:S}})),t.addedRepr=!0,D.label=20;case 20:c.focus&&this.plugin.managers.camera.focusLoci(l),this.plugin.managers.interactivity.lociSelects.deselect({loci:l}),D.label=21;case 21:return[3,16];case 22:return[3,29];case 23:return x=D.sent(),E={error:x},[3,29];case 24:return D.trys.push([24,,27,28]),u&&!u.done&&(A=o.return)?[4,A.call(o)]:[3,26];case 25:D.sent(),D.label=26;case 26:return[3,28];case 27:if(E)throw E.error;return[7];case 28:return[7];case 29:return this.visual.reset({selectColor:!0}),this.selectedParams=t,[2]}}))}))},clearSelection:function(){return n.__awaiter(e,void 0,void 0,(function(){var e,t,r,i,o,s,u,c,l,d;return n.__generator(this,(function(f){switch(f.label){case 0:return this.plugin.managers.interactivity.lociSelects.deselectAll(),this.selectedParams&&this.selectedParams.nonSelectedColor&&this.visual.reset({theme:!0}),[4,A.clearStructureOverpaint(this.plugin,this.plugin.managers.structure.hierarchy.current.structures[0].components)];case 1:if(f.sent(),!this.selectedParams||!this.selectedParams.addedRepr)return[3,15];for(e=[],t=0,r=this.plugin.managers.structure.hierarchy.current.structures[0].components;t<r.length;t++)(i=r[t]).cell&&i.cell.params&&i.cell.params.values&&"selection-by-script"===i.cell.params.values.label&&e.push(i.cell);if(!(e.length>0))return[3,15];f.label=2;case 2:f.trys.push([2,8,9,14]),o=n.__asyncValues(e),f.label=3;case 3:return[4,o.next()];case 4:return(s=f.sent()).done?[3,7]:(u=s.value,[4,a.PluginCommands.State.RemoveObject(this.plugin,{state:u.parent,ref:u.transform.ref})]);case 5:f.sent(),f.label=6;case 6:return[3,3];case 7:return[3,14];case 8:return c=f.sent(),l={error:c},[3,14];case 9:return f.trys.push([9,,12,13]),s&&!s.done&&(d=o.return)?[4,d.call(o)]:[3,11];case 10:f.sent(),f.label=11;case 11:return[3,13];case 12:if(l)throw l.error;return[7];case 13:return[7];case 14:f.label=15;case 15:return this.selectedParams=void 0,[2]}}))}))},update:function(t,r){return n.__awaiter(e,void 0,void 0,(function(){var e,a;return n.__generator(this,(function(o){if(!t)return[2];for(e in this.initParams=n.__assign({},i.DefaultParams),i.DefaultParams)void 0!==t[e]&&(this.initParams[e]=t[e]);return this.initParams.moleculeId||this.initParams.customData?this.initParams.customData&&this.initParams.customData.url&&!this.initParams.customData.format?[2,!1]:(this.plugin.customState.initParams=this.initParams,this.initParams.bgColor&&this.canvas.setBgColor(this.initParams.bgColor),(a=this.getMoleculeSrcUrl())&&this.load({url:a.url,format:a.format,assemblyId:this.initParams.assemblyId,isBinary:a.isBinary},r),[2]):[2,!1]}))}))},visibility:function(t){if(t){var r={polymer:"structure-component-static-polymer",het:"structure-component-static-ligand",water:"structure-component-static-water",carbs:"structure-component-static-branched",maps:"volume-streaming-info"};for(var n in t){var i=r[n],s=f.StateSelection.findTagInSubtree(e.plugin.state.data.tree,o.StateTransform.RootRef,i);if(s){var u=e.plugin.state.data.select(s)[0];if(u&&u.obj){var c=!u.state||!u.state.isHidden;t[n]!==c&&a.PluginCommands.State.ToggleVisibility(e.plugin,{state:e.state,ref:s})}}}}},toggleSpin:function(t,r){if(e.plugin.canvas3d){var i=e.plugin.canvas3d.props.trackball;void 0===t&&(t=!i.spin),a.PluginCommands.Canvas3D.SetSettings(e.plugin,{settings:{trackball:n.__assign(n.__assign({},i),{spin:t})}}),r&&a.PluginCommands.Camera.Reset(e.plugin,{})}},focus:function(t){return n.__awaiter(e,void 0,void 0,(function(){var e;return n.__generator(this,(function(r){return e=this.getLociForParams(t),this.plugin.managers.camera.focusLoci(e),[2]}))}))},setColor:function(t){if(e.plugin.canvas3d){var r=e.plugin.canvas3d.props.renderer,i={};t.highlight&&(i.highlightColor=e.normalizeColor(t.highlight)),t.select&&(i.selectColor=e.normalizeColor(t.select)),a.PluginCommands.Canvas3D.SetSettings(e.plugin,{settings:{renderer:n.__assign(n.__assign({},r),i)}}),i.highlightColor&&(e.isHighlightColorUpdated=!0)}},reset:function(t){return n.__awaiter(e,void 0,void 0,(function(){var e,r,i=this;return n.__generator(this,(function(o){switch(o.label){case 0:return t.camera?[4,a.PluginCommands.Camera.Reset(this.plugin,{durationMs:250})]:[3,2];case 1:o.sent(),o.label=2;case 2:if(t.theme&&this.plugin.managers.structure.hierarchy.currentComponentGroups.forEach((function(e){i.plugin.managers.structure.component.updateRepresentationsTheme(e,{color:"default"})})),t.highlightColor||t.selectColor){if(!this.plugin.canvas3d)return[2];e=this.plugin.canvas3d.props.renderer,r={},t.highlightColor&&(r.highlightColor=this.defaultRendererProps.highlightColor),t.selectColor&&(r.selectColor=this.defaultRendererProps.selectColor),a.PluginCommands.Canvas3D.SetSettings(this.plugin,{settings:{renderer:n.__assign(n.__assign({},e),r)}}),r.highlightColor&&(this.isHighlightColorUpdated=!1)}return[2]}}))}))}},this._ev=u.RxEventHelper.create(),this.events={loadComplete:this._ev()},this.applyVisualParams=function(){var t={"structure-component-static-polymer":"polymer","structure-component-static-ligand":"het","structure-component-static-branched":"carbs","structure-component-static-water":"water","structure-component-static-coarse":"coarse","non-standard":"nonStandard"};e.plugin.managers.structure.hierarchy.currentComponentGroups.forEach((function(r){var n,i=r[0].key,a=!1;if(i&&e.initParams.hideStructure){var o=t[i];o&&(null===(n=e.initParams.hideStructure)||void 0===n?void 0:n.indexOf(o))>-1&&(a=!0)}a&&e.plugin.managers.structure.hierarchy.remove(r),!a&&e.initParams.visualStyle&&r[0]&&r[0].representations&&r[0].representations.forEach((function(t){var n=g.createStructureRepresentationParams(e.plugin,void 0,{type:e.initParams.visualStyle});e.plugin.managers.structure.component.updateRepresentations(r,t,n)}))}))}}return Object.defineProperty(e.prototype,"state",{get:function(){return this.plugin.state.data},enumerable:!1,configurable:!0}),e.prototype.render=function(e,t){if(t){for(var r in this.initParams=n.__assign({},i.DefaultParams),i.DefaultParams)void 0!==t[r]&&(this.initParams[r]=t[r]);if(!this.initParams.moleculeId&&!this.initParams.customData)return!1;if(this.initParams.customData&&this.initParams.customData.url&&!this.initParams.customData.format)return!1;var o={actions:n.__spreadArrays(i.DefaultPluginSpec.actions),behaviors:n.__spreadArrays(i.DefaultPluginSpec.behaviors),animations:n.__spreadArrays(i.DefaultPluginSpec.animations||[]),customParamEditors:i.DefaultPluginSpec.customParamEditors,config:i.DefaultPluginSpec.config};if(this.initParams.ligandView||this.initParams.superposition||!this.initParams.selectInteraction||o.behaviors.push(m.PluginSpec.Behavior(p.StructureFocusRepresentation)),this.initParams.superposition){o.behaviors.push(m.PluginSpec.Behavior(T.SuperpositionFocusRepresentation))}if(this.initParams.domainAnnotation&&o.behaviors.push(m.PluginSpec.Behavior(j.PDBeDomainAnnotations,{autoAttach:!0,showTooltip:!1})),this.initParams.validationAnnotation&&o.behaviors.push(m.PluginSpec.Behavior(P.PDBeStructureQualityReport,{autoAttach:!0,showTooltip:!1})),o.layout={initial:{isExpanded:!this.initParams.landscape&&this.initParams.expanded,showControls:!this.initParams.hideControls},controls:{left:b.LeftPanelControls,top:"none",bottom:"none"}},o.components={viewport:{controls:d.PDBeViewportControls,view:this.initParams.superposition?I.SuperpostionViewport:void 0},remoteState:"none",structureTools:this.initParams.superposition?l.PDBeSuperpositionStructureTools:this.initParams.ligandView?l.PDBeLigandViewStructureTools:l.PDBeStructureTools},o.config=[[x.PluginConfig.Structure.DefaultRepresentationPresetParams,{theme:{carbonByChainId:!1,focus:{name:"element-symbol",params:{carbonByChainId:!1}}}}]],this.initParams.ligandView||this.initParams.superposition||(o.animations=[E.AnimateModelIndex]),this.initParams.hideCanvasControls&&(this.initParams.hideCanvasControls.indexOf("expand")>-1&&o.config.push([x.PluginConfig.Viewport.ShowExpand,!1]),this.initParams.hideCanvasControls.indexOf("selection")>-1&&o.config.push([x.PluginConfig.Viewport.ShowSelectionMode,!1]),this.initParams.hideCanvasControls.indexOf("animation")>-1&&o.config.push([x.PluginConfig.Viewport.ShowAnimation,!1])),this.initParams.landscape&&o.layout&&o.layout.initial&&(o.layout.initial.controlsDisplay="landscape"),this.targetElement="string"==typeof e?document.getElementById(e):e,this.plugin=i.createPlugin(this.targetElement,o),this.plugin.customState.initParams=n.__assign({},this.initParams),this.plugin.customState.events={segmentUpdate:this._ev(),superpositionInit:this._ev(),isBusy:this._ev()},this.initParams.bgColor&&this.canvas.setBgColor(this.initParams.bgColor),this.initParams.granularity&&this.plugin.managers.interactivity.setProps({granularity:this.initParams.granularity}),(this.initParams.highlightColor||this.initParams.selectColor)&&this.visual.setColor({highlight:this.initParams.highlightColor,select:this.initParams.selectColor}),this.defaultRendererProps=n.__assign({},this.plugin.canvas3d.props.renderer),this.initParams.superposition)this.plugin.behaviors.layout.leftPanelTabName.next("segments"),y.initSuperposition(this.plugin);else{a.PluginCommands.Layout.Update(this.plugin,{state:{regionState:n.__assign(n.__assign({},this.plugin.layout.state.regionState),{left:"collapsed"})}}),this.plugin.behaviors.layout.leftPanelTabName.next("none");var s=this.getMoleculeSrcUrl();s&&this.load({url:s.url,format:s.format,assemblyId:this.initParams.assemblyId,isBinary:s.isBinary}),this.initParams.subscribeEvents&&v.subscribeToComponentEvents(this),_.CustomEvents.add(this.plugin,this.targetElement)}}},e.prototype.getMoleculeSrcUrl=function(){var e=this.initParams.moleculeId;if(!e&&!this.initParams.customData)throw new Error("Mandatory parameters missing!");var t="full",r="?";if(this.initParams.ligandView){var n=["data_source=pdb-h"];this.initParams.ligandView.label_comp_id_list||(this.initParams.ligandView.label_comp_id?n.push("label_comp_id="+this.initParams.ligandView.label_comp_id):this.initParams.ligandView.auth_seq_id&&n.push("auth_seq_id="+this.initParams.ligandView.auth_seq_id),this.initParams.ligandView.auth_asym_id&&n.push("auth_asym_id="+this.initParams.ligandView.auth_asym_id)),t="residueSurroundings?"+n.join("&"),r="&"}var i=this.initParams.pdbeUrl+"model-server/v1/"+e+"/"+t+r+"encoding="+this.initParams.encoding+(this.initParams.lowPrecisionCoords?"&lowPrecisionCoords=1":""),a="bcif"===this.initParams.encoding,o="mmcif";if(this.initParams.customData){if(!this.initParams.customData.url||!this.initParams.customData.format)throw new Error("Provide all custom data parameters");if(i=this.initParams.customData.url,"cif"!==(o=this.initParams.customData.format)&&"bcif"!==o||(o="mmcif"),-1===["mmcif","pdb","sdf"].indexOf(o))throw new Error(o+" not supported.");a=!!this.initParams.customData.binary&&this.initParams.customData.binary}return{url:i,format:o,isBinary:a}},e.prototype.createLigandStructure=function(e){var t,r,i;return n.__awaiter(this,void 0,void 0,(function(){var s,u,l,d,p,m,h,g,v,b,y,_=this;return n.__generator(this,(function(S){switch(S.label){case 0:if(""===this.assemblyRef)return[2];S.label=1;case 1:S.trys.push([1,7,8,13]),s=n.__asyncValues(this.plugin.managers.structure.hierarchy.currentComponentGroups),S.label=2;case 2:return[4,s.next()];case 3:return(u=S.sent()).done?[3,6]:(l=u.value,[4,a.PluginCommands.State.RemoveObject(this.plugin,{state:l[0].cell.parent,ref:l[0].cell.transform.ref,removeParentGhosts:!0})]);case 4:S.sent(),S.label=5;case 5:return[3,2];case 6:return[3,13];case 7:return d=S.sent(),t={error:d},[3,13];case 8:return S.trys.push([8,,11,12]),u&&!u.done&&(r=s.return)?[4,r.call(s)]:[3,10];case 9:S.sent(),S.label=10;case 10:return[3,12];case 11:if(t)throw t.error;return[7];case 12:return[7];case 13:return p=this.state.select(this.assemblyRef)[0],m=e?c.LigandView.branchedQuery(null===(i=this.initParams.ligandView)||void 0===i?void 0:i.label_comp_id_list):c.LigandView.query(this.initParams.ligandView),[4,this.plugin.builders.structure.tryCreateComponentFromExpression(p,m.core,"pivot",{label:"Ligand"})];case 14:return(h=S.sent())?[4,this.plugin.builders.structure.representation.addRepresentation(h,{type:"ball-and-stick",color:"element-symbol",colorParams:{carbonByChainId:!1},size:"uniform",sizeParams:{value:2.5}},{tag:"ligand-vis"})]:[3,16];case 15:S.sent(),S.label=16;case 16:return[4,this.plugin.builders.structure.tryCreateComponentFromExpression(p,m.surroundings,"rest",{label:"Surroundings"})];case 17:return(g=S.sent())?[4,this.plugin.builders.structure.representation.addRepresentation(g,{type:"ball-and-stick",color:"element-symbol",colorParams:{carbonByChainId:!1},size:"uniform",sizeParams:{value:.8}})]:[3,19];case 18:S.sent(),S.label=19;case 19:return(v=f.StateSelection.findTagInSubtree(this.plugin.state.data.tree,o.StateTransform.RootRef,"ligand-vis"))?((b=this.plugin.state.data.cells.get(v))&&(y=b.obj.data.repr.getLoci(),this.plugin.managers.structure.focus.setFromLoci(y),setTimeout((function(){var e,t=null===(e=_.plugin.managers.structure.focus.current)||void 0===e?void 0:e.loci;t&&_.plugin.managers.camera.focusLoci(t)}),500)),[2]):[2]}}))}))},e.prototype.load=function(e,t){var r=e.url,i=e.format,a=void 0===i?"mmcif":i,o=e.isBinary,s=void 0!==o&&o,u=e.assemblyId,l=void 0===u?"":u;return void 0===t&&(t=!0),n.__awaiter(this,void 0,void 0,(function(){var e,i,o,u,d,f,p,m,g,v,b;return n.__generator(this,(function(n){switch(n.label){case 0:return t&&this.clear(),e=!!this.initParams.ligandView,i=void 0,o=!1,this.initParams.ligandView&&this.initParams.ligandView.label_comp_id_list&&(o=!0,i={body:JSON.stringify(this.initParams.ligandView.label_comp_id_list),headers:[["Content-type","application/json"]]}),[4,this.plugin.builders.data.download({url:S.Asset.Url(r,i),isBinary:s},{state:{isGhost:!0}})];case 1:return u=n.sent(),[4,this.plugin.builders.structure.parseTrajectory(u,a)];case 2:return d=n.sent(),e?[3,4]:[4,this.plugin.builders.structure.hierarchy.applyPreset(d,"default",{structure:l?"preferred"===l?void 0:{name:"assembly",params:{id:l}}:{name:"model",params:{}},showUnitcell:!1,representationPreset:"auto"})];case 3:return n.sent(),(this.initParams.hideStructure||this.initParams.visualStyle)&&this.applyVisualParams(),[3,7];case 4:return[4,this.plugin.builders.structure.createModel(d)];case 5:return f=n.sent(),[4,this.plugin.builders.structure.createStructure(f,{name:"model",params:{}})];case 6:n.sent(),n.label=7;case 7:return this.initParams.selection&&this.visual.select(this.initParams.selection),p=this.plugin.managers.structure.hierarchy.selection.structures.length-1,(m=this.plugin.managers.structure.hierarchy.selection.structures[p])&&m.cell.parent&&(this.assemblyRef=m.cell.transform.ref),this.initParams.loadMaps?""===this.assemblyRef?[2]:(g=this.state.select(this.assemblyRef)[0].obj,v=h.InitVolumeStreaming.createDefaultParams(g,this.plugin),(b=c.PDBeVolumes.mapParams(v,this.initParams.mapSettings,""))?[4,this.plugin.runTask(this.state.applyAction(h.InitVolumeStreaming,b,this.assemblyRef))]:[3,9]):[3,9];case 8:n.sent(),"em"===b.method||this.initParams.ligandView||c.PDBeVolumes.displayUsibilityMessage(this.plugin),n.label=9;case 9:return e?[4,this.createLigandStructure(o)]:[3,11];case 10:n.sent(),n.label=11;case 11:return this.events.loadComplete.next(!0),[2]}}))}))},e.prototype.getLociForParams=function(e){if(""===this.assemblyRef)return s.EmptyLoci;var t=this.plugin.state.data.select(this.assemblyRef)[0].obj.data;return t?c.QueryHelper.getInteractivityLoci(e,t):s.EmptyLoci},e.prototype.normalizeColor=function(e,t){var r=O.Color.fromRgb(170,170,170);try{r=e.r?O.Color.fromRgb(e.r,e.g,e.b):"#"===e[0]?O.Color(Number("0x"+e.substr(1))):O.Color(e)}catch(e){t&&(r=t)}return r},e.prototype.clear=function(){return n.__awaiter(this,void 0,void 0,(function(){return n.__generator(this,(function(e){return this.plugin.clear(),this.assemblyRef="",this.selectedParams=void 0,this.isHighlightColorUpdated=!1,this.isSelectedColorUpdated=!1,[2]}))}))},e}();window.PDBeMolstarPlugin=M},function(e,t,r){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.DefaultParams=t.createPlugin=t.DefaultPluginSpec=void 0;var n=r(0),i=n.__importStar(r(3)),a=n.__importStar(r(421)),o=r(425),s=r(447),u=r(177),c=r(308),l=r(446),d=r(407),f=r(78),p=r(433);t.DefaultPluginSpec={actions:[],behaviors:[d.PluginSpec.Behavior(u.PluginBehaviors.Representation.HighlightLoci),d.PluginSpec.Behavior(u.PluginBehaviors.Representation.SelectLoci),d.PluginSpec.Behavior(p.PDBeLociLabelProvider),d.PluginSpec.Behavior(u.PluginBehaviors.Representation.FocusLoci),d.PluginSpec.Behavior(u.PluginBehaviors.Camera.FocusLoci),d.PluginSpec.Behavior(u.PluginBehaviors.CustomProps.AccessibleSurfaceArea),d.PluginSpec.Behavior(u.PluginBehaviors.CustomProps.Interactions),d.PluginSpec.Behavior(u.PluginBehaviors.CustomProps.SecondaryStructure),d.PluginSpec.Behavior(u.PluginBehaviors.CustomProps.ValenceModel),d.PluginSpec.Behavior(u.PluginBehaviors.CustomProps.CrossLinkRestraint)],customParamEditors:[[c.CreateVolumeStreamingBehavior,o.VolumeStreamingCustomControls]],config:[[f.PluginConfig.VolumeStreaming.DefaultServer,"https://www.ebi.ac.uk/pdbe/densities"]]},t.createPlugin=function(e,r){var n=new l.PluginContext(r||t.DefaultPluginSpec);return a.render(i.createElement(s.Plugin,{plugin:n}),e),n},t.DefaultParams={moleculeId:void 0,superposition:void 0,superpositionParams:void 0,customData:void 0,ligandView:void 0,assemblyId:void 0,visualStyle:void 0,highlightColor:void 0,selectColor:void 0,hideStructure:void 0,hideCanvasControls:void 0,granularity:void 0,selection:void 0,mapSettings:void 0,pdbeUrl:"https://www.ebi.ac.uk/pdbe/",bgColor:{r:0,g:0,b:0},encoding:"bcif",selectInteraction:!0,loadMaps:!1,validationAnnotation:!1,domainAnnotation:!1,lowPrecisionCoords:!1,expanded:!1,hideControls:!1,pdbeLink:!0,loadCartoonsOnly:!1,landscape:!1,subscribeEvents:!1}},function(e,t,r){"use strict";
/** @license React v17.0.2
 * react.production.min.js
 *
 * Copyright (c) Facebook, Inc. and its affiliates.
 *
 * This source code is licensed under the MIT license found in the
 * LICENSE file in the root directory of this source tree.
 */var n=r(406),i=60103,a=60106;t.Fragment=60107,t.StrictMode=60108,t.Profiler=60114;var o=60109,s=60110,u=60112;t.Suspense=60113;var c=60115,l=60116;if("function"==typeof Symbol&&Symbol.for){var d=Symbol.for;i=d("react.element"),a=d("react.portal"),t.Fragment=d("react.fragment"),t.StrictMode=d("react.strict_mode"),t.Profiler=d("react.profiler"),o=d("react.provider"),s=d("react.context"),u=d("react.forward_ref"),t.Suspense=d("react.suspense"),c=d("react.memo"),l=d("react.lazy")}var f="function"==typeof Symbol&&Symbol.iterator;function p(e){for(var t="https://reactjs.org/docs/error-decoder.html?invariant="+e,r=1;r<arguments.length;r++)t+="&args[]="+encodeURIComponent(arguments[r]);return"Minified React error #"+e+"; visit "+t+" for the full message or use the non-minified dev environment for full errors and additional helpful warnings."}var m={isMounted:function(){return!1},enqueueForceUpdate:function(){},enqueueReplaceState:function(){},enqueueSetState:function(){}},h={};function g(e,t,r){this.props=e,this.context=t,this.refs=h,this.updater=r||m}function v(){}function b(e,t,r){this.props=e,this.context=t,this.refs=h,this.updater=r||m}g.prototype.isReactComponent={},g.prototype.setState=function(e,t){if("object"!=typeof e&&"function"!=typeof e&&null!=e)throw Error(p(85));this.updater.enqueueSetState(this,e,t,"setState")},g.prototype.forceUpdate=function(e){this.updater.enqueueForceUpdate(this,e,"forceUpdate")},v.prototype=g.prototype;var y=b.prototype=new v;y.constructor=b,n(y,g.prototype),y.isPureReactComponent=!0;var _={current:null},S=Object.prototype.hasOwnProperty,x={key:!0,ref:!0,__self:!0,__source:!0};function O(e,t,r){var n,a={},o=null,s=null;if(null!=t)for(n in void 0!==t.ref&&(s=t.ref),void 0!==t.key&&(o=""+t.key),t)S.call(t,n)&&!x.hasOwnProperty(n)&&(a[n]=t[n]);var u=arguments.length-2;if(1===u)a.children=r;else if(1<u){for(var c=Array(u),l=0;l<u;l++)c[l]=arguments[l+2];a.children=c}if(e&&e.defaultProps)for(n in u=e.defaultProps)void 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/** @license React v17.0.2
 * react-dom.production.min.js
 *
 * Copyright (c) Facebook, Inc. and its affiliates.
 *
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u=t.plugin.state.behaviors.build().to(o.id).update(o,(function(e){e.showTooltip=!0}));if(t.plugin.runTask(t.plugin.state.behaviors.updateTree(u)),s){var c=t.plugin.state.behaviors.build().to(s.id).update(s,(function(e){e.showTooltip=!1}));t.plugin.runTask(t.plugin.state.behaviors.updateTree(c))}}t.plugin.managers.structure.hierarchy.currentComponentGroups.forEach((function(e){"structure-component-static-polymer"===e[0].key&&(i=e)})),i&&t.plugin.managers.structure.component.updateRepresentationsTheme(i,{color:a,colorParams:n||void 0})},t.initApplyAnnotation=function(e){0===e&&t.applyAnnotation(0,!t.state.validationApplied,t.state.validationParams.values),1===e&&t.applyAnnotation(1,!t.state.domainAtnApplied,t.state.domainAtnParams.values)},t.updateValidationParams=function(e){var r=n.__assign({},t.state.validationParams);r.values=e,t.setState({validationParams:r}),t.state.validationApplied&&t.applyAnnotation(0,t.state.validationApplied,e)},t.updateDomainAtnParams=function(e){var r=n.__assign({},t.state.domainAtnParams);r.values=e,t.setState({domainAtnParams:r}),t.state.domainAtnApplied&&t.applyAnnotation(1,t.state.domainAtnApplied,e)},t}return n.__extends(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.managers.structure.hierarchy.behaviors.selection,(function(){e.getOptionParams(),e.forceUpdate()})),this.subscribe(this.plugin.managers.structure.hierarchy.behaviors.selection,(function(t){return e.setState({description:m.StructureHierarchyManager.getSelectedStructuresDescription(e.plugin)})}))},t.prototype.render=function(){var e=this;if(!this.state.validationParams&&!this.state.domainAtnParams)return i.createElement(i.Fragment,null);var t={accent:"green",svg:g},r=this.state.isCollapsed?"msp-transform-wrapper msp-transform-wrapper-collapsed":"msp-transform-wrapper";return i.createElement("div",{className:r},i.createElement("div",{className:"msp-transform-header"},i.createElement(a.Button,{icon:t?void 0:this.state.isCollapsed?p.ArrowRightSvg:p.ArrowDropDownSvg,noOverflow:!0,onClick:this.toggleCollapsed,className:t?"msp-transform-header-brand msp-transform-header-brand-"+t.accent:void 0,title:"Click to "+(this.state.isCollapsed?"expand":"collapse")},i.createElement(p.Icon,{svg:null==t?void 0:t.svg,inline:!0}),"Annotations",i.createElement("small",{style:{margin:"0 6px"}},this.state.isCollapsed?"":this.state.description))),!this.state.isCollapsed&&this.state.validationParams&&i.createElement("div",{className:"msp-flex-row"},i.createElement(a.Button,{noOverflow:!0,className:"msp-control-button-label",title:"Validation Report Annotations.",style:{textAlign:"left"}},"Validation Report"),i.createElement(a.IconButton,{onClick:function(){return e.initApplyAnnotation(0)},toggleState:!1,svg:this.state.validationApplied?p.VisibilityOutlinedSvg:p.VisibilityOffOutlinedSvg,title:"Click to "+(this.state.validationApplied?"Hide":"Show")+" Validation Report 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e.initApplyAnnotation(1)},toggleState:!1,svg:this.state.domainAtnApplied?p.VisibilityOutlinedSvg:p.VisibilityOffOutlinedSvg,title:"Click to "+(this.state.domainAtnApplied?"Hide":"Show")+" Domain Annotation",small:!0,className:"msp-form-control",flex:!0}),i.createElement(a.IconButton,{onClick:function(){return e.toggleOptions(1)},svg:p.MoreHorizSvg,title:"Actions",toggleState:this.state.domainAtnOptions,className:"msp-form-control",flex:!0})),!this.state.isCollapsed&&this.state.domainAtnParams&&this.state.domainAtnOptions&&i.createElement("div",{style:{marginBottom:"6px"}},i.createElement("div",{className:"msp-accent-offset"},i.createElement("div",{className:"msp-representation-entry"},i.createElement(c.ParameterControls,{params:this.state.domainAtnParams.params,values:this.state.domainAtnParams.values,onChangeValues:this.updateDomainAtnParams})))))},t}(o.PurePluginUIComponent);t.AnnotationsComponentControls=v},function(e,t,r){"use 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r=t.state.componentGroups.ligGroups.filter((function(t){return t[0].key.split(",")[0].split("-")[2].toLowerCase().indexOf(e.toLowerCase())>=0}));t.setState({ligGroups:r})},t.carbInputStream=new p.Subject,t.handleCarbInputStream=function(e){t.setState({carbSearchText:e});var r=t.state.componentGroups.carbGroups.filter((function(t){var r=t[0].key.split(",")[0].split("-");return r.splice(0,2),r.pop(),r.join("-").toLowerCase().indexOf(e.toLowerCase())>=0}));t.setState({carbGroups:r})},t.toggleVisible=function(e,r,i){e.preventDefault(),e.currentTarget.blur();var a=t.plugin.customState;a.events.isBusy.next(!0);var o="ligands"===i?t.state.ligGroups:t.state.carbGroups;setTimeout((function(){return n.__awaiter(t,void 0,void 0,(function(){var e,t,i,s,u,c;return n.__generator(this,(function(l){switch(l.label){case 0:l.trys.push([0,5,6,11]),e=n.__asyncValues(o),l.label=1;case 1:return[4,e.next()];case 2:if((t=l.sent()).done)return[3,4];i=t.value,this.plugin.managers.structure.hierarchy.toggleVisibility(i,r),l.label=3;case 3:return[3,1];case 4:return[3,11];case 5:return s=l.sent(),u={error:s},[3,11];case 6:return l.trys.push([6,,9,10]),t&&!t.done&&(c=e.return)?[4,c.call(e)]:[3,8];case 7:l.sent(),l.label=8;case 8:return[3,10];case 9:if(u)throw u.error;return[7];case 10:return[7];case 11:return a.events.isBusy.next(!1),[2]}}))}))}))},t.showHideAllControls=function(e){return i.createElement(i.Fragment,null,i.createElement(c.Button,{icon:l.CheckSvg,flex:!0,onClick:function(r){return t.toggleVisible(r,"show",e)},style:{flex:"0 0 50px",textAlign:"center",fontSize:"80%",color:"#9cacc3",padding:0},title:"Show all "+e,disabled:!1},"All"),i.createElement(c.Button,{icon:l.CloseSvg,flex:!0,onClick:function(r){return t.toggleVisible(r,"hide",e)},style:{flex:"0 0 50px",textAlign:"center",fontSize:"80%",color:"#9cacc3",padding:0},title:"Hide all "+e,disabled:!1},"None"))},t.clearLigSearch=function(e){e.preventDefault(),t.setState({ligSearchText:""}),t.ligInputStream.next(""),e.currentTarget.blur()},t.clearCarbSearch=function(e){e.preventDefault(),t.setState({carbSearchText:""}),t.carbInputStream.next(""),e.currentTarget.blur()},t.collapseSection=function(e,r){e.preventDefault(),e.currentTarget.blur(),"ligands"===r?t.setState({isLigCollapsed:!t.state.isLigCollapsed}):t.setState({isCarbCollapsed:!t.state.isCarbCollapsed})},t.sectionHeader=function(e){var r="ligands"===e?t.showHideAllControls("ligands"):t.showHideAllControls("carbohydrates"),n="ligands"===e?"Ligand":"Carbohydrates",a="ligands"===e?t.state.ligGroups.length:t.state.carbGroups.length,o="ligands"===e?t.state.componentGroups.ligGroups.length:t.state.componentGroups.carbGroups.length;return i.createElement("div",{className:"msp-flex-row",style:{marginTop:"6px"}},i.createElement("button",{className:"msp-form-control msp-control-button-label msp-transform-header-brand-gray",style:{textAlign:"left"},onClick:function(r){return t.collapseSection(r,e)}},i.createElement("span",null,i.createElement("strong",null,n)),i.createElement("small",{style:{color:"#7d91b0"}}," ( ",a,a<o?" / "+o:""," )")),a>1&&r)},t}return n.__extends(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.managers.structure.hierarchy.behaviors.selection,(function(){e.categoriseGroups(),e.forceUpdate()})),this.subscribe(this.plugin.behaviors.state.isBusy,(function(t){e.setState({isBusy:t})}))},t.prototype.componentDidUpdate=function(){var e=this,t=this.plugin.customState;t.events&&!this.state.segmentWatch&&(this.setState({segmentWatch:!0}),this.subscribe(t.events.segmentUpdate,(function(){e.categoriseGroups(),e.forceUpdate()}))),this.subscribe(this.ligInputStream.pipe(f.debounceTime(1e3/24)),(function(t){return e.handleLigInputStream(t)})),this.subscribe(this.carbInputStream.pipe(f.debounceTime(1e3/24)),(function(t){return e.handleCarbInputStream(t)}))},t.prototype.categoriseGroups=function(){var e={nonLigGroups:[],ligGroups:[],carbGroups:[]},t=this.plugin.managers.structure.hierarchy.currentComponentGroups,r=this.plugin.customState;t.forEach((function(t){var n=!1;if(r.initParams&&r.initParams.superpositionParams&&r.initParams.superpositionParams.ligandView&&(n=!0),n){var i=(a=t[0].key.split(","))[0].split("-");if(-1===a.indexOf("superposition-focus-surr-sel")){if(i[i.length-1]!==r.superpositionState.activeSegment-1+"")return;a.indexOf("superposition-ligand-sel")>=0?e.ligGroups.push(t):a.indexOf("superposition-carb-sel")>=0?e.carbGroups.push(t):e.nonLigGroups.push(t)}else e.nonLigGroups.push(t)}else{var a;((a=t[0].key.split(",")).indexOf("superposition-focus-surr-sel")>=0||a.indexOf("Chain-"+(r.superpositionState.activeSegment-1))>=0)&&e.nonLigGroups.push(t)}})),this.setState({componentGroups:e,ligGroups:e.ligGroups,carbGroups:e.carbGroups,ligSearchText:"",carbSearchText:""})},t.prototype.render=function(){var e=this,t=i.createElement("div",{className:"msp-mapped-parameter-group",style:{fontSize:"90%"}},i.createElement("div",{className:"msp-control-row msp-transform-header-brand-gray",style:{height:"33px"}},i.createElement("span",{className:"msp-control-row-label"},"Search Ligand"),i.createElement("div",{className:"msp-control-row-ctrl"},i.createElement("input",{type:"text",placeholder:"Enter HET code",disabled:this.state.isBusy,onChange:function(t){return e.ligInputStream.next(t.target.value)},value:this.state.ligSearchText,maxLength:3}))),i.createElement(c.IconButton,{svg:l.CloseSvg,flex:!0,onClick:this.clearLigSearch,style:{flex:"0 0 24px",padding:0},disabled:""===this.state.ligSearchText||this.state.isBusy,toggleState:""!==this.state.ligSearchText,title:"Clear search input"})),r=i.createElement("div",{className:"msp-mapped-parameter-group",style:{fontSize:"90%"}},i.createElement("div",{className:"msp-control-row msp-transform-header-brand-gray",style:{height:"33px"}},i.createElement("span",{className:"msp-control-row-label"},"Search Carbohydrate"),i.createElement("div",{className:"msp-control-row-ctrl"},i.createElement("input",{type:"text",placeholder:"Enter HET code",disabled:this.state.isBusy,onChange:function(t){return e.carbInputStream.next(t.target.value)},value:this.state.carbSearchText,maxLength:3}))),i.createElement(c.IconButton,{svg:l.CloseSvg,flex:!0,onClick:this.clearCarbSearch,style:{flex:"0 0 24px",padding:0},disabled:""===this.state.carbSearchText||this.state.isBusy,toggleState:""!==this.state.carbSearchText,title:"Clear search input"})),n=this.sectionHeader("ligands"),a=this.sectionHeader("carbohydrates");return i.createElement(i.Fragment,null,this.state.componentGroups.nonLigGroups.length>0&&i.createElement("div",null,this.state.componentGroups.nonLigGroups.map((function(e){return i.createElement(g,{key:e[0].cell.transform.ref,group:e,boldHeader:!0})}))),this.state.componentGroups.ligGroups.length>0&&n,!this.state.isLigCollapsed&&this.state.componentGroups.ligGroups.length>5&&t,this.state.componentGroups.ligGroups.length>0&&i.createElement("div",{className:"msp-control-offset",style:{maxHeight:"800px",overflowY:"auto"}},!this.state.isLigCollapsed&&this.state.ligGroups.map((function(e){return i.createElement(g,{key:e[0].cell.transform.ref,group:e,boldHeader:!1})}))),this.state.componentGroups.carbGroups.length>0&&a,!this.state.isCarbCollapsed&&this.state.componentGroups.carbGroups.length>5&&r,this.state.componentGroups.carbGroups.length>0&&i.createElement("div",{className:"msp-control-offset",style:{maxHeight:"800px",overflowY:"auto"}},!this.state.isCarbCollapsed&&this.state.carbGroups.map((function(e){return i.createElement(g,{key:e[0].cell.transform.ref,group:e,boldHeader:!1})}))))},t}(u.PurePluginUIComponent),g=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={action:void 0,isHidden:!1,isBusy:!1},t.checkAllHidden=function(){return n.__awaiter(t,void 0,void 0,(function(){var e,t,r;return n.__generator(this,(function(n){for(e=!0,t=0,r=this.props.group;t<r.length;t++)if(!r[t].cell.state.isHidden){e=!1;break}return e&&this.setState({isHidden:!0}),[2]}))}))},t.toggleVisible=function(e){e.preventDefault(),e.currentTarget.blur(),t.plugin.managers.structure.component.toggleVisibility(t.props.group),t.setState({isHidden:!t.state.isHidden})},t.toggleAction=function(){return t.setState({action:"action"===t.state.action?void 0:"action"})},t.highlight=function(e){e.preventDefault(),t.props.group[0].cell.parent&&a.PluginCommands.Interactivity.Object.Highlight(t.plugin,{state:t.props.group[0].cell.parent,ref:t.props.group.map((function(e){return e.cell.transform.ref}))})},t.clearHighlight=function(e){e.preventDefault(),a.PluginCommands.Interactivity.ClearHighlights(t.plugin)},t.focus=function(){for(var e=!0,r=0,n=t.props.group;r<n.length;r++){if(!n[r].cell.state.isHidden){e=!1;break}}e&&t.plugin.managers.structure.hierarchy.toggleVisibility(t.props.group,"show"),t.plugin.managers.camera.focusSpheres(t.props.group,(function(e){var t;if(!e.cell.state.isHidden)return null===(t=e.cell.obj)||void 0===t?void 0:t.data.boundary.sphere}))},t}return n.__extends(t,e),Object.defineProperty(t.prototype,"pivot",{get:function(){return this.props.group[0]},enumerable:!1,configurable:!0}),t.prototype.componentDidMount=function(){var e=this;this.checkAllHidden(),this.subscribe(this.plugin.state.events.cell.stateUpdated,(function(t){var r,n;(null===(r=e.pivot.cell.obj)||void 0===r?void 0:r.label)===(null===(n=t.cell.obj)||void 0===n?void 0:n.label)&&(t.cell.state.isHidden?e.checkAllHidden():e.setState({isHidden:!1}))})),this.subscribe(this.plugin.behaviors.state.isBusy,(function(t){e.setState({isBusy:t})})),this.subscribe(this.plugin.customState.events.isBusy,(function(t){e.setState({isBusy:t})}))},t.prototype.render=function(){var e,t=this,r=this.pivot,n=null===(e=r.cell.obj)||void 0===e?void 0:e.label,a=this.props.boldHeader?i.createElement("strong",null,n):n;return i.createElement(i.Fragment,null,i.createElement("div",{className:"msp-flex-row"},i.createElement(c.Button,{noOverflow:!0,className:"msp-control-button-label",title:n+" - Click to focus.",onClick:this.focus,style:{textAlign:"left"},disabled:this.state.isBusy},a),i.createElement(c.IconButton,{disabled:this.state.isBusy,svg:this.state.isHidden?l.VisibilityOffOutlinedSvg:l.VisibilityOutlinedSvg,toggleState:!1,onClick:this.toggleVisible,title:(this.state.isHidden?"Show":"Hide")+" component",small:!0,className:"msp-form-control",flex:!0}),i.createElement(c.IconButton,{disabled:this.state.isBusy,svg:l.MoreHorizSvg,onClick:this.toggleAction,title:"Actions",toggleState:"action"===this.state.action,className:"msp-form-control",flex:!0})),"action"===this.state.action&&i.createElement("div",{className:"msp-accent-offset"},i.createElement("div",{style:{marginBottom:"6px"}},r.representations.map((function(e){return i.createElement(v,{group:t.props.group,key:e.cell.transform.ref,representation:e})})))))},t}(u.PurePluginUIComponent),v=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={isBusy:!1,clusterVal:{cluster:"All"}},t.remove=function(){return t.plugin.managers.structure.component.removeRepresentations(t.props.group,t.props.representation)},t.toggleVisible=function(e){e.preventDefault(),e.currentTarget.blur(),t.plugin.managers.structure.component.toggleVisibility(t.props.group,t.props.representation)},t.update=function(e){return t.updateRepresentations(t.props.group,t.props.representation,e)},t.selectCluster=function(e){t.setState({clusterVal:{cluster:e.cluster}})},t}return n.__extends(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.state.events.cell.stateUpdated,(function(t){o.State.ObjectEvent.isCell(t,e.props.representation.cell)&&e.forceUpdate()})),this.subscribe(this.plugin.behaviors.state.isBusy,(function(t){e.setState({isBusy:t})})),this.subscribe(this.plugin.customState.events.isBusy,(function(t){e.setState({isBusy:t})}))},t.prototype.updateRepresentations=function(e,t,r){var n,i,a;if(0===e.length)return Promise.resolve();var o=e[0].representations.indexOf(t);if(o<0)return Promise.resolve();var s=this.plugin.customState.superpositionState,u=[];if("All"!==this.state.clusterVal.cluster&&0===(u=s.segmentData[s.activeSegment-1].clusters[parseInt(this.state.clusterVal.cluster)-1].map((function(e){return e.pdb_id+"_"+e.struct_asym_id}))).length)return;for(var c=this.plugin.state.data.build(),l=0,d=e;l<d.length;l++){var f=d[l].representations[o];if(f&&f.cell.transform.transformer===t.cell.transform.transformer){if("All"!==this.state.clusterVal.cluster)if(-1===u.indexOf(s.refMaps[f.cell.transform.parent]))continue;var p={type:r.type?r.type:null===(n=f.cell.params)||void 0===n?void 0:n.values.type,colorTheme:r.colorTheme?r.colorTheme:null===(i=f.cell.params)||void 0===i?void 0:i.values.colorTheme,sizeTheme:r.sizeTheme?r.sizeTheme:null===(a=f.cell.params)||void 0===a?void 0:a.values.sizeTheme};c.to(f.cell).update(p)}}return c.commit({canUndo:"Update Representation"})},t.prototype.render=function(){var e,t,r,n,a,o,u=this.props.representation.cell,c=this.plugin.customState.superpositionState,l=[["All","All"]];c.segmentData[c.activeSegment-1].clusters.forEach((function(e,t){l.push([t+1+"",t+1+""])}));var f={cluster:s.ParamDefinition.Select("All",l,{label:"Select Cluster"})},p=!1;if(u&&u.obj){var m=u.obj;m.tags&&m.tags.indexOf("superposition-focus-surr-repr")>=0&&(p=!0)}return i.createElement("div",{className:"msp-representation-entry"},u.parent&&i.createElement("div",null,l.length>2&&!p&&i.createElement("div",{className:"msp-representation-entry"},i.createElement(d.ParameterControls,{params:f,values:this.state.clusterVal,onChangeValues:this.selectCluster,isDisabled:this.state.isBusy})),i.createElement("div",{className:"msp-representation-entry"},i.createElement(d.ParameterControls,{params:{type:null===(e=u.params)||void 0===e?void 0:e.definition.type},values:{type:null===(t=u.params)||void 0===t?void 0:t.values.type},onChangeValues:this.update,isDisabled:this.state.isBusy})),i.createElement("div",{className:"msp-representation-entry"},i.createElement(d.ParameterControls,{params:{colorTheme:null===(r=u.params)||void 0===r?void 0:r.definition.colorTheme},values:{colorTheme:null===(n=u.params)||void 0===n?void 0:n.values.colorTheme},onChangeValues:this.update,isDisabled:this.state.isBusy})),i.createElement("div",{className:"msp-representation-entry"},i.createElement(d.ParameterControls,{params:{sizeTheme:null===(a=u.params)||void 0===a?void 0:a.definition.sizeTheme},values:{sizeTheme:null===(o=u.params)||void 0===o?void 0:o.values.sizeTheme},onChangeValues:this.update,isDisabled:this.state.isBusy}))))},t}(u.PurePluginUIComponent)},function(e,t,r){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.PDBeViewportControls=void 0;var n=r(0),i=n.__importStar(r(3)),a=r(78),o=r(18),s=r(213),u=r(438),c=r(403),l=r(329),d=r(15),f=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return n.__extends(t,e),t.prototype.isBlack=function(e){if(e&&e.initParams&&e.initParams.bgColor){var t=e.initParams.bgColor;if(0===t.r&&0===t.g&&0===t.b)return!0}return!1},t.prototype.render=function(){var e=this.plugin.customState,t=!1;e&&e.initParams&&e.initParams.moleculeId&&e.initParams.pdbeLink&&(t=!0),e&&e.initParams&&e.initParams.superposition&&(t=!1);var r={parentStyle:{width:"auto"},containerStyle:{position:"absolute",right:"10px",top:"10px"},style:{display:"inline-block",fontSize:"14px",color:this.isBlack(e)?"#fff":"#555",borderBottom:"none",cursor:"pointer",textDecoration:"none"},pdbeImg:{src:"https://www.ebi.ac.uk/pdbe/entry/static/images/logos/PDBe/logo_T_64.png",alt:"PDBe logo",style:{height:"12px",width:"12px",border:0,position:"absolute",margin:"4px 0 0 -13px"}}};return i.createElement(i.Fragment,null,t&&i.createElement("div",{style:r.containerStyle},i.createElement("a",{className:"msp-pdbe-link",style:r.style,target:"_blank",href:"https://pdbe.org/"+e.initParams.moleculeId},i.createElement("img",{src:r.pdbeImg.src,alt:r.pdbeImg.alt,style:r.pdbeImg.style}),e.initParams.moleculeId)),i.createElement("div",{className:"msp-viewport-controls",onMouseMove:this.onMouseMove,style:t?{marginTop:"22px"}:void 0},i.createElement("div",{className:"msp-viewport-controls-buttons"},i.createElement("div",null,i.createElement("div",{className:"msp-semi-transparent-background"}),this.icon(d.AutorenewSvg,this.resetCamera,"Reset Camera")),i.createElement("div",null,i.createElement("div",{className:"msp-semi-transparent-background"}),this.icon(d.CameraOutlinedSvg,this.toggleScreenshotExpanded,"Screenshot / State Snapshot",this.state.isScreenshotExpanded)),i.createElement("div",null,i.createElement("div",{className:"msp-semi-transparent-background"}),this.icon(d.BuildOutlinedSvg,this.toggleControls,"Toggle Controls Panel",this.plugin.layout.state.showControls),this.plugin.config.get(a.PluginConfig.Viewport.ShowExpand)&&this.icon(d.FullscreenSvg,this.toggleExpanded,"Toggle Expanded Viewport",this.plugin.layout.state.isExpanded),this.icon(d.TuneSvg,this.toggleSettingsExpanded,"Settings / Controls Info",this.state.isSettingsExpanded)),this.plugin.config.get(a.PluginConfig.Viewport.ShowSelectionMode)&&i.createElement("div",null,i.createElement("div",{className:"msp-semi-transparent-background"}),i.createElement(s.ToggleSelectionModeButton,null))),this.state.isScreenshotExpanded&&i.createElement("div",{className:"msp-viewport-controls-panel"},i.createElement(o.ControlGroup,{header:"Screenshot / State",title:"Click to close.",initialExpanded:!0,hideExpander:!0,hideOffset:!0,onHeaderClick:this.toggleScreenshotExpanded,topRightIcon:d.CloseSvg,noTopMargin:!0,childrenClassName:"msp-viewport-controls-panel-controls"},i.createElement(u.DownloadScreenshotControls,{close:this.toggleScreenshotExpanded}))),this.state.isSettingsExpanded&&i.createElement("div",{className:"msp-viewport-controls-panel"},i.createElement(o.ControlGroup,{header:"Settings / Controls Info",title:"Click to close.",initialExpanded:!0,hideExpander:!0,hideOffset:!0,onHeaderClick:this.toggleSettingsExpanded,topRightIcon:d.CloseSvg,noTopMargin:!0,childrenClassName:"msp-viewport-controls-panel-controls"},i.createElement(c.SimpleSettingsControl,null)))))},t}(l.ViewportControls);t.PDBeViewportControls=f},function(e,t,r){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.DownloadScreenshotControls=void 0;var n=r(0),i=n.__importStar(r(3)),a=r(73),o=r(33),s=r(279),u=r(156),c=r(18),l=r(27),d=r(15),f=function(e){function t(){var t,r,a,o=e.apply(this,arguments)||this;return o.state={showPreview:!0,isDisabled:!1,resolution:null===(t=o.plugin.helpers.viewportScreenshot)||void 0===t?void 0:t.params.resolution,transparent:null===(r=o.plugin.helpers.viewportScreenshot)||void 0===r?void 0:r.params.transparent,axes:null===(a=o.plugin.helpers.viewportScreenshot)||void 0===a?void 0:a.params.axes},o.imgRef=i.createRef(),o.updateQueue=new u.Subject,o.preview=function(){return n.__awaiter(o,void 0,void 0,(function(){var e;return n.__generator(this,(function(t){switch(t.label){case 0:return this.imgRef.current?(e=this.imgRef.current,[4,this.plugin.helpers.viewportScreenshot.getImageDataUri()]):[2];case 1:return e.src=t.sent(),[2]}}))}))},o.download=function(){var e;null===(e=o.plugin.helpers.viewportScreenshot)||void 0===e||e.download(),o.props.close()},o.openTab=function(){for(var e=o.imgRef.current.src,t=atob(e.substr("data:image/png;base64,".length)),r=[],n=Math.min(t.length,1048576),i=0;i<t.length;i+=n){for(var a=new Uint8Array(Math.min(n,t.length-i)),s=0,u=a.length;s<u;s++)a[s]=t.charCodeAt(i+s);r.push(a)}var c=new Blob(r,{type:"image/png"}),l=URL.createObjectURL(c);window.open(l,"_blank"),o.props.close()},o.setProps=function(e){"resolution"===e.name?(o.plugin.helpers.viewportScreenshot.params.resolution=e.value,o.setState({resolution:e.value})):"transparent"===e.name?(o.plugin.helpers.viewportScreenshot.params.transparent=e.value,o.setState({transparent:e.value})):"axes"===e.name&&(o.plugin.helpers.viewportScreenshot.params.axes=e.value,o.setState({axes:e.value}))},o.downloadToFileJson=function(){l.PluginCommands.State.Snapshots.DownloadToFile(o.plugin,{type:"json"})},o.downloadToFileZip=function(){l.PluginCommands.State.Snapshots.DownloadToFile(o.plugin,{type:"zip"})},o.open=function(e){e.target.files&&e.target.files[0]&&l.PluginCommands.State.Snapshots.OpenFile(o.plugin,{file:e.target.files[0]})},o}return n.__extends(t,e),t.prototype.handlePreview=function(){this.state.showPreview&&this.preview()},t.prototype.componentDidUpdate=function(){this.updateQueue.next()},t.prototype.componentDidMount=function(){var e=this;this.plugin.canvas3d&&(this.subscribe(s.debounceTime(250)(this.updateQueue),(function(){return e.handlePreview()})),this.subscribe(this.plugin.events.canvas3d.settingsUpdated,(function(){var t;e.plugin.helpers.viewportScreenshot.imagePass.setProps({multiSample:{mode:"on",sampleLevel:2},postprocessing:null===(t=e.plugin.canvas3d)||void 0===t?void 0:t.props.postprocessing}),e.updateQueue.next()})),this.subscribe(s.debounceTime(250)(this.plugin.canvas3d.didDraw),(function(){e.state.isDisabled||e.updateQueue.next()})),this.subscribe(this.plugin.state.data.behaviors.isUpdating,(function(t){e.setState({isDisabled:t}),t||e.updateQueue.next()})),this.handlePreview())},t.prototype.render=function(){return i.createElement("div",null,i.createElement("div",{className:"msp-image-preview"},i.createElement("img",{ref:this.imgRef}),i.createElement("br",null),i.createElement("span",null,"Right-click the image to Copy.")),i.createElement("div",{className:"msp-flex-row"},i.createElement(c.Button,{icon:d.GetAppSvg,onClick:this.download,disabled:this.state.isDisabled},"Download"),i.createElement(c.Button,{icon:d.LaunchSvg,onClick:this.openTab,disabled:this.state.isDisabled},"Open in new Tab")),i.createElement(a.ParameterControls,{params:this.plugin.helpers.viewportScreenshot.params,values:this.plugin.helpers.viewportScreenshot.values,onChange:this.setProps,isDisabled:this.state.isDisabled}))},t}(o.PluginUIComponent);t.DownloadScreenshotControls=f},function(e,t,r){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.subscribeToComponentEvents=void 0,t.subscribeToComponentEvents=function(e){document.addEventListener("PDB.interactions.click",(function(t){if(void 0!==t.detail){var r=t.detail.interacting_nodes?{data:t.detail.interacting_nodes}:{data:[t.detail.selected_node]};r.data[0].focus=!0,e.visual.select(r)}})),document.addEventListener("PDB.interactions.mouseover",(function(t){if(void 0!==t.detail){var r=t.detail.interacting_nodes?{data:t.detail.interacting_nodes}:{data:[t.detail.selected_node]};e.visual.highlight(r)}})),document.addEventListener("PDB.interactions.mouseout",(function(t){e.visual.clearHighlight()})),document.addEventListener("PDB.topologyViewer.click",(function(t){if(void 0!==t.eventData){var r={entity_id:t.eventData.entityId,struct_asym_id:t.eventData.structAsymId,start_residue_number:t.eventData.residueNumber,end_residue_number:t.eventData.residueNumber,sideChain:!0,focus:!0};e.visual.select({data:[r]})}})),document.addEventListener("PDB.topologyViewer.mouseover",(function(t){if(void 0!==t.eventData){var r={entity_id:t.eventData.entityId,struct_asym_id:t.eventData.structAsymId,start_residue_number:t.eventData.residueNumber,end_residue_number:t.eventData.residueNumber};e.visual.highlight({data:[r]})}})),document.addEventListener("PDB.topologyViewer.mouseout",(function(t){e.visual.clearHighlight()})),document.addEventListener("protvista-mouseover",(function(t){if(void 0!==t.detail){var r=void 0;t.detail.start&&t.detail.end&&(r={start_residue_number:parseInt(t.detail.start),end_residue_number:parseInt(t.detail.end)}),t.detail.feature&&t.detail.feature.entityId&&(r.entity_id=t.detail.feature.entityId+""),t.detail.feature&&t.detail.feature.bestChainId&&(r.struct_asym_id=t.detail.feature.bestChainId),r&&e.visual.highlight({data:[r]})}})),document.addEventListener("protvista-mouseout",(function(t){e.visual.clearHighlight()})),document.addEventListener("protvista-click",(function(t){if(void 0!==t.detail){var r=!1,n=void 0;if(t.detail.start&&t.detail.end&&(n={start_residue_number:parseInt(t.detail.start),end_residue_number:parseInt(t.detail.end)}),t.detail.feature&&t.detail.feature.entityId&&(n.entity_id=t.detail.feature.entityId+""),t.detail.feature&&t.detail.feature.bestChainId&&(n.struct_asym_id=t.detail.feature.bestChainId),(t.detail.feature&&t.detail.feature.accession&&"Chain"===t.detail.feature.accession.split(" ")[0]||"Ligand binding site"===t.detail.feature.tooltipContent)&&(r=!0),t.detail.start===t.detail.end&&(r=!0),n){if(r)n.sideChain=!0;else{var i=void 0;if(t.detail.trackIndex>-1&&t.detail.feature.locations&&t.detail.feature.locations[0].fragments[t.detail.trackIndex].color&&(i=t.detail.feature.locations[0].fragments[t.detail.trackIndex].color),void 0===i&&t.detail.feature.color&&(i=t.detail.feature.color),void 0===i&&t.detail.color&&(i=t.detail.color),void 0===i)i={r:65,g:96,b:91};else{if(/rgb/g.test(i)){var a=i.substring(4,i.length-1).split(",");i={r:a[0],g:a[1],b:a[2]}}}n.color=i}n.focus=!0,e.visual.select({data:[n]})}}}));var t=["uniprot","pfam","cath","scop","strand","helice"],r=["chain","quality","quality_outlier","binding site","alternate conformer"];document.addEventListener("PDB.seqViewer.click",(function(n){if(void 0!==n.eventData)if(void 0!==n.eventData.elementData&&r.indexOf(n.eventData.elementData.elementType)>-1){var i={entity_id:n.eventData.entityId,struct_asym_id:n.eventData.elementData.pathData.struct_asym_id,start_residue_number:n.eventData.residueNumber,end_residue_number:n.eventData.residueNumber,sideChain:!0,focus:!0};e.visual.select({data:[i]})}else if(void 0!==n.eventData.elementData&&t.indexOf(n.eventData.elementData.elementType)>-1){var a=n.eventData.elementData.color;i={entity_id:n.eventData.entityId,struct_asym_id:n.eventData.elementData.pathData.struct_asym_id,start_residue_number:n.eventData.elementData.pathData.start.residue_number,end_residue_number:n.eventData.elementData.pathData.end.residue_number,color:{r:a[0],g:a[1],b:a[2]},focus:!0};e.visual.select({data:[i]})}})),document.addEventListener("PDB.seqViewer.mouseover",(function(n){if(void 0!==n.eventData)if(void 0!==n.eventData.elementData&&r.indexOf(n.eventData.elementData.elementType)>-1){var i={entity_id:n.eventData.entityId,struct_asym_id:n.eventData.elementData.pathData.struct_asym_id,start_residue_number:n.eventData.residueNumber,end_residue_number:n.eventData.residueNumber,focus:!0};e.visual.select({data:[i]})}else if(void 0!==n.eventData.elementData&&t.indexOf(n.eventData.elementData.elementType)>-1){i={entity_id:n.eventData.entityId,struct_asym_id:n.eventData.elementData.pathData.struct_asym_id,start_residue_number:n.eventData.elementData.pathData.start.residue_number,end_residue_number:n.eventData.elementData.pathData.end.residue_number};e.visual.highlight({data:[i]})}})),document.addEventListener("PDB.seqViewer.mouseout",(function(t){e.visual.clearHighlight()}))}},function(e,t,r){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.LeftPanelControls=t.WavesIconSvg=void 0;var n=r(0),i=n.__importStar(r(3)),a=r(146),o=r(27),s=r(13),u=r(33),c=r(18),l=r(73),d=r(399),f=r(292),p=r(386),m=r(195),h=r(441),g=r(15),v=r(195),b=i.createElement("svg",{width:"24px",height:"24px",viewBox:"0 0 24 24"},i.createElement("path",{d:"M17 16.99c-1.35 0-2.2.42-2.95.8-.65.33-1.18.6-2.05.6-.9 0-1.4-.25-2.05-.6-.75-.38-1.57-.8-2.95-.8s-2.2.42-2.95.8c-.65.33-1.17.6-2.05.6v1.95c1.35 0 2.2-.42 2.95-.8.65-.33 1.17-.6 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r.plugin.behaviors.layout.leftPanelTabName.next(e)})),"full"!==r.plugin.layout.state.regionState.left&&o.PluginCommands.Layout.Update(r.plugin,{state:{regionState:n.__assign(n.__assign({},r.plugin.layout.state.regionState),{left:"full"})}})},r.tabs={none:i.createElement(i.Fragment,null),root:i.createElement(i.Fragment,null,i.createElement(c.SectionHeader,{icon:g.HomeOutlinedSvg,title:"Home"}),i.createElement(d.StateObjectActions,{state:r.plugin.state.data,nodeRef:s.StateTransform.RootRef,hideHeader:!0,initiallyCollapsed:!0,alwaysExpandFirst:!0}),"none"!==(null===(t=r.plugin.spec.components)||void 0===t?void 0:t.remoteState)&&i.createElement(f.RemoteStateSnapshots,{listOnly:!0})),data:i.createElement(i.Fragment,null,i.createElement(c.SectionHeader,{icon:g.AccountTreeOutlinedSvg,title:i.createElement(i.Fragment,null,i.createElement(x,null)," State 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t.remove=function(e){e.preventDefault(),o.PluginCommands.State.RemoveObject(t.plugin,{state:t.plugin.state.data,ref:s.StateTransform.RootRef})},t}return n.__extends(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.state.events.cell.created,(function(t){t.cell.transform.parent===s.StateTransform.RootRef&&e.forceUpdate()})),this.subscribe(this.plugin.state.events.cell.removed,(function(t){t.parent===s.StateTransform.RootRef&&e.forceUpdate()}))},t.prototype.render=function(){return 0===this.plugin.state.data.tree.children.get(s.StateTransform.RootRef).size?null:i.createElement(c.IconButton,{svg:g.DeleteOutlinedSvg,onClick:this.remove,title:"Remove All",style:{display:"inline-block"},small:!0,className:"msp-no-hover-outline",transparent:!0})},t}(u.PluginUIComponent);function O(e){return i.createElement("div",{className:"msp-simple-help-section"},e.header)}var w=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return n.__extends(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.events.canvas3d.settingsUpdated,(function(){return e.forceUpdate()}))},t.prototype.render=function(){return i.createElement("div",null,i.createElement(O,{header:"Superposition"}),i.createElement(v.HelpGroup,{header:"Segment"},i.createElement(v.HelpText,null,i.createElement("p",null,"Discrete UniProt sequence range mapped to the structure"))),i.createElement(v.HelpGroup,{header:"Cluster"},i.createElement(v.HelpText,null,i.createElement("p",null,"Structural chains that possess significantly close superposition Q-score"))),i.createElement(v.HelpGroup,{header:"Representative chain"},i.createElement(v.HelpText,null,i.createElement("p",null,"The best-ranked chain within a cluster chosen based on the model quality, resolution, observed residues ratio and UniProt sequence coverage"))))},t}(u.PluginUIComponent)},function(e,t,r){"use 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0;["labels","distances","angles","dihedrals"].forEach((function(e){n||r[e][0]&&(n=t.plugin.state.data.cells.get(r[e][0].transform.parent))})),n&&o.PluginCommands.State.RemoveObject(t.plugin,{state:n.parent,ref:n.transform.parent,removeParentGhosts:!0});var i=t.customState;i.superpositionState.visibleRefs[e]=[];for(var a=0,s=i.superpositionState.loadedStructs[e];a<s.length;a++){var u=s[a],c=t.customState.superpositionState.models[u];if(c){var l=t.plugin.managers.structure.hierarchy.current.refs.get(c);if(l&&l.components)for(var d=0,f=l.components;d<f.length;d++){var p=f[d];p&&p.cell&&!p.cell.state.isHidden&&(i.superpositionState.visibleRefs[e].push(p.cell.transform.ref),o.PluginCommands.State.ToggleVisibility(t.plugin,{state:p.cell.parent,ref:p.cell.transform.ref}))}}}},t.displayStructures=function(e){return n.__awaiter(t,void 0,void 0,(function(){var t,r,i,a,s,u,c=this;return n.__generator(this,(function(n){switch(n.label){case 0:return 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n.__extends(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.customState.events.superpositionInit,(function(){var t=e.customState;t&&!t.superpositionError&&e.getSegmentParams(),e.forceUpdate()})),this.subscribe(this.plugin.customState.events.isBusy,(function(t){e.setState({isBusy:t}),t?o.PluginCommands.Toast.Show(e.plugin,{title:"Process",message:"Loading / computing large dataset!",key:"is-busy-toast"}):o.PluginCommands.Toast.Hide(e.plugin,{key:"is-busy-toast"})})),this.subscribe(this.plugin.behaviors.layout.leftPanelTabName,(function(t){"segments"===t&&(e.getSegmentParams(),e.forceUpdate())}))},Object.defineProperty(t.prototype,"customState",{get:function(){return this.plugin.customState},enumerable:!1,configurable:!0}),t.prototype.render=function(){var e=i.createElement(c.SectionHeader,{title:"Structure clusters"}),t=this.customState;if(t&&t.initParams&&!t.initParams.superposition)return i.createElement(i.Fragment,null,e,i.createElement("div",null,"Functionality unavailable!"));if(t&&t.initParams&&t.initParams.superposition){if(e=i.createElement(c.SectionHeader,{title:"Structure clusters - "+t.initParams.moleculeId}),t.superpositionError)return i.createElement(i.Fragment,null,e,i.createElement("div",{style:{textAlign:"center"}},t.superpositionError));if(!t.superpositionState||!t.superpositionState.segmentData)return i.createElement(i.Fragment,null,e,i.createElement("div",{style:{textAlign:"center"}},"Loading Segment Data!"))}if(this.state){var r=parseInt(this.state.segment.value.segment.split(" ")[0])-1,n=t.superpositionState.segmentData,a="( "+n[0].segment_start+" - "+n[n.length-1].segment_end+" )";return e=i.createElement(c.SectionHeader,{title:"Structure clusters 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2:return[4,i.next()];case 3:return(a=g.sent()).done?[3,8]:(s=a.value,u=s.pdb_id+"_"+s.struct_asym_id,c=void 0,t&&t.superpositionState&&t.superpositionState.models[u]&&(c=this.customState.superpositionState.models[u]),c?(l=this.plugin.state.data.cells.get(c))&&((d=!!l.state.isHidden)&&r.showAll||!d&&r.showNone)?[4,o.PluginCommands.State.ToggleVisibility(this.plugin,{state:l.parent,ref:c})]:[3,5]:[3,6]);case 4:g.sent(),g.label=5;case 5:return[3,7];case 6:r.showAll&&e.push(s),g.label=7;case 7:return[3,2];case 8:return[3,15];case 9:return f=g.sent(),m={error:f},[3,15];case 10:return g.trys.push([10,,13,14]),a&&!a.done&&(h=i.return)?[4,h.call(i)]:[3,12];case 11:g.sent(),g.label=12;case 12:return[3,14];case 13:if(m)throw m.error;return[7];case 14:return[7];case 15:return o.PluginCommands.Camera.Reset(this.plugin),e.length>0?[4,p.renderSuperposition(this.plugin,this.props.segmentIndex,e)]:[3,17];case 16:g.sent(),g.label=17;case 17:return t.events.isBusy.next(!1),[2]}}))}))})),[2]}))}))},t.cancelAction=function(e){e.preventDefault(),t.setState({showAll:!1,showNone:!1}),e.currentTarget.blur()},t.clearSearch=function(e){e.preventDefault(),t.setState({searchText:""}),t.inputStream.next(""),e.currentTarget.blur()},t}return n.__extends(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.customState.events.isBusy,(function(t){e.setState({isBusy:t,showAll:!1,showNone:!1})})),this.subscribe(this.inputStream.pipe(a.debounceTime(1e3/24)),(function(t){return e.handleInputStream(t)}))},Object.defineProperty(t.prototype,"customState",{get:function(){return this.plugin.customState},enumerable:!1,configurable:!0}),t.prototype.render=function(){var e=this,t=this.customState;if(!t.superpositionState||!t.superpositionState.segmentData)return i.createElement(i.Fragment,null);var r=i.createElement(c.IconButton,{svg:this.state.isCollapsed?h.ArrowRightSvg:h.ArrowDropDownSvg,flex:"20px",onClick:this.toggleExpanded,transparent:!0,disabled:this.state.isBusy,className:"msp-no-hover-outline"}),n="Segment "+t.superpositionState.activeSegment+" Cluster "+(this.props.clusterIndex+1),a=i.createElement(c.Button,{className:"msp-btn-tree-label",noOverflow:!0,title:n,disabled:this.state.isBusy},i.createElement("span",null,"Cluster ",this.props.clusterIndex+1)," ",i.createElement("small",null,this.state.cluster.length<this.props.cluster.length?this.state.cluster.length+" / ":"",this.props.cluster.length," chain",this.props.cluster.length>1?"s":"")),o=i.createElement(i.Fragment,null,i.createElement(c.Button,{icon:h.CheckSvg,flex:!0,onClick:this.selectAll,style:{flex:"0 0 50px",textAlign:"center",fontSize:"80%",color:"#9cacc3",padding:0},disabled:this.state.isBusy,title:"Show all chains"},"All"),i.createElement(c.Button,{icon:h.CloseSvg,flex:!0,onClick:this.selectNone,style:{flex:"0 0 50px",textAlign:"center",fontSize:"80%",color:"#9cacc3",padding:0},disabled:this.state.isBusy,title:"Hide all chains"},"None")),s=i.createElement("div",{className:"msp-flex-row msp-tree-row",style:{marginTop:"10px"}},r,a,this.props.cluster.length>1&&o),u=i.createElement("div",{className:"msp-mapped-parameter-group",style:{fontSize:"90%"}},i.createElement("div",{className:"msp-control-row msp-transform-header-brand-gray",style:{height:"33px",marginLeft:"30px"}},i.createElement("span",{className:"msp-control-row-label"},"Search PDB ID"),i.createElement("div",{className:"msp-control-row-ctrl"},i.createElement("input",{type:"text",placeholder:"Enter PDB ID..",disabled:this.state.isBusy,onChange:function(t){return e.inputStream.next(t.target.value)},value:this.state.searchText,maxLength:4}))),i.createElement(c.IconButton,{svg:h.CloseSvg,flex:!0,onClick:this.clearSearch,style:{flex:"0 0 24px",padding:0},disabled:this.state.isBusy||""===this.state.searchText,toggleState:""!==this.state.searchText,title:"Clear search input"}));return i.createElement(i.Fragment,null,s,(this.state.showAll||this.state.showNone)&&i.createElement("div",null,i.createElement("div",{className:"msp-control-row msp-transform-header-brand-"+(this.state.showAll?"green":"red"),style:{display:"flex",marginLeft:"20px",height:"35px"}},i.createElement("span",{className:"msp-control-row-label",style:{flex:"1 1 auto",textAlign:"left",fontSize:"85%"}},this.state.showAll?"Display":"Hide"," ",this.state.cluster.length<this.props.cluster.length?this.state.cluster.length+" / ":"all ",this.props.cluster.length," chains"),i.createElement(c.Button,{icon:h.CheckSvg,flex:!0,onClick:this.applyAction,style:{flex:"0 0 60px",textAlign:"center",fontSize:"78%",color:"#9cacc3",padding:0,margin:"0 1px"},title:"Apply action"},"Apply"),i.createElement(c.Button,{icon:h.CloseSvg,flex:!0,onClick:this.cancelAction,style:{flex:"0 0 60px",textAlign:"center",fontSize:"78%",color:"#9cacc3",padding:0,margin:"0 1px"},title:"Cancel action"},"Cancel"))),!this.state.isCollapsed&&this.props.cluster.length>5&&u,!this.state.isCollapsed&&i.createElement("div",{className:"msp-tree-updates-wrapper",style:{maxHeight:this.props.totalClusters>1?"330px":"87%",overflowY:"auto"}},this.state.cluster.map((function(t,r){return i.createElement(x,{segmentIndex:e.props.segmentIndex,structure:t,isRep:0===r,key:"str-"+t.pdb_id+t.struct_asym_id+r})}))))},t}(u.PluginUIComponent),x=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={showControls:!1,isBusy:!1,isProcessing:!1,isHidden:!0},t.toggleVisible=function(e){return n.__awaiter(t,void 0,void 0,(function(){var t,r,i,a;return n.__generator(this,(function(n){switch(n.label){case 0:if(e.preventDefault(),e.currentTarget.blur(),this.setState({isProcessing:!0,showControls:!1}),!this.ref)return[3,1];if((t=this.plugin.managers.structure.hierarchy.current.refs.get(this.ref))&&t.components){for(r=0,i=t.components;r<i.length;r++)a=i[r],!!a.cell.state.isHidden===this.state.isHidden&&o.PluginCommands.State.ToggleVisibility(this.plugin,{state:a.cell.parent,ref:a.cell.transform.ref});this.setState({isHidden:!this.state.isHidden})}return[3,3];case 1:return[4,p.renderSuperposition(this.plugin,this.props.segmentIndex,[this.props.structure])];case 2:n.sent(),n.label=3;case 3:return this.setState({isProcessing:!1}),o.PluginCommands.Camera.Reset(this.plugin),[2]}}))}))},t.selectAction=function(e){e&&(t.setState({showControls:!1}),(null==e?void 0:e.value)())},t.highlight=function(e){if(e.preventDefault(),t.ref){var r=t.plugin.state.data.cells.get(t.ref);o.PluginCommands.Interactivity.Object.Highlight(t.plugin,{state:r.parent,ref:t.ref})}e.currentTarget.blur()},t.clearHighlight=function(e){e.preventDefault(),o.PluginCommands.Interactivity.ClearHighlights(t.plugin),e.currentTarget.blur()},t.toggleControls=function(e){e.preventDefault(),t.setState({showControls:!t.state.showControls}),e.currentTarget.blur()},t}return n.__extends(t,e),Object.defineProperty(t.prototype,"customState",{get:function(){return this.plugin.customState},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"ref",{get:function(){return this.customState&&this.customState.superpositionState&&this.customState.superpositionState.models[this.props.structure.pdb_id+"_"+this.props.structure.struct_asym_id]?this.customState.superpositionState.models[this.props.structure.pdb_id+"_"+this.props.structure.struct_asym_id]:void 0},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"modelCell",{get:function(){return this.ref?this.plugin.state.data.cells.get(this.ref):void 0},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"isAllHidden",{get:function(){var e=!0;if(this.ref){var t=this.plugin.managers.structure.hierarchy.current.refs.get(this.ref);if(t&&t.components)for(var r=0,n=t.components;r<n.length;r++){var i=n[r];if(i&&i.cell&&!i.cell.state.isHidden){e=!1;break}}else e=!1}return e},enumerable:!1,configurable:!0}),t.prototype.checkRelation=function(e){var t=!1,r=this.plugin.state.data.cells.get(e);if(r&&r.transform.parent)if(r&&r.transform.parent===this.ref)t=!0;else{var n=this.plugin.state.data.cells.get(r.transform.parent);n&&n.transform.parent===this.ref&&(t=!0)}else{var i=this.plugin.state.data.cells.get(this.ref);i&&i.transform.parent===r.transform.parent&&(t=!0)}return t},t.prototype.is=function(e){if(!this.ref)return!1;var t=!1;return this.ref&&e.ref!==this.ref&&(t=this.checkRelation(e.ref)),!(e.ref!==this.ref&&!t)||!!(this.customState.superpositionState.invalidStruct.indexOf(this.props.structure.pdb_id+"_"+this.props.structure.struct_asym_id)>-1)},t.prototype.componentDidMount=function(){var e=this;this.setState({isHidden:this.isAllHidden}),this.subscribe(this.plugin.customState.events.isBusy,(function(t){e.setState({isBusy:t,showControls:!1})})),this.subscribe(this.plugin.state.events.cell.stateUpdated.pipe(a.filter((function(t){return e.is(t)})),a.debounceTime(33)),(function(t){e.setState({isHidden:e.isAllHidden})}))},t.prototype.getTagRefs=function(e){var t=new Set(e),r=this.plugin.state.data.tree;return f.StateSelection.findUniqueTagsInSubtree(r,this.modelCell.transform.ref,t)},t.prototype.getRandomColor=function(){var e=g.ColorLists,t=this.plugin.customState.superpositionState,r=t.colorState[this.props.segmentIndex].palleteIndex,n=t.colorState[this.props.segmentIndex].colorIndex;e[t.colorPalette[r]].list[n+1]?n+=1:(n=0,r=t.colorPalette[r+1]?r+1:0);var i=t.colorPalette[r];return this.plugin.customState.superpositionState.colorState[this.props.segmentIndex].palleteIndex=r,this.plugin.customState.superpositionState.colorState[this.props.segmentIndex].colorIndex=n,e[i].list[n]},t.prototype.addChainRepr=function(){return n.__awaiter(this,void 0,void 0,(function(){var e,t,r,i;return n.__generator(this,(function(n){switch(n.label){case 0:return e=this.getRandomColor(),t=this.plugin.state.data.select(this.ref)[0],r=b.MolScriptBuilder.struct.generator.atomGroups({"chain-test":b.MolScriptBuilder.core.rel.eq([b.MolScriptBuilder.struct.atomProperty.macromolecular.label_asym_id(),this.props.structure.struct_asym_id])}),[4,this.plugin.builders.structure.tryCreateComponentFromExpression(t,r,"Chain-"+this.props.segmentIndex,{label:"Chain",tags:["superposition-sel"]})];case 1:return(i=n.sent())?[4,this.plugin.builders.structure.representation.addRepresentation(i,{type:"cartoon",color:"uniform",colorParams:{value:e}},{tag:"superposition-visual"})]:[3,3];case 2:n.sent(),n.label=3;case 3:return[2]}}))}))},t.prototype.updates=function(){var e=this,t=this.plugin.managers.structure.hierarchy.current.refs.get(this.ref);if(t&&t.components){var r=[],n=!0;t.components.forEach((function(e){"Chain"===e.key.split(",")[0].split("-")[2]&&(n=!1),e.representations&&e.representations.forEach((function(e){r.push(e)}))}));var a=this.plugin.customState;if(a.initParams&&a.initParams.superpositionParams&&!a.initParams.superpositionParams.ligandView&&(n=!1),r.length>0)return i.createElement("div",{className:"msp-accent-offset",style:{marginLeft:"40px"}},r.length>0&&r.map((function(e,r){return i.createElement(O,{group:[t],key:e.cell.transform.ref+"-"+r,representation:e})})),n&&i.createElement("div",{className:"msp-control-group-header",style:{marginTop:"1px"}},i.createElement(c.Button,{noOverflow:!0,className:"msp-control-button-label",title:"Click to add chain representaion",onClick:function(){return e.addChainRepr()}},"  Add Chain ",this.props.structure.struct_asym_id," Representation")))}return i.createElement(i.Fragment,null)},t.prototype.getSubtitle=function(){var e,t=this.plugin.customState.superpositionState.hets[this.props.structure.pdb_id+"_"+this.props.structure.struct_asym_id];if(t){var r=this.props.structure.is_representative?1:4,n=t.length,i=t.join(", ");n>r&&(i=t.slice(0,r).join(", "),i+=" + "+(n-r)),e=" ( "+i+" )",this.props.structure.is_representative&&(e=" "+e+" ( Representative )")}else this.props.structure.is_representative&&(e=" ( Representative )");return e},Object.defineProperty(t.prototype,"panelColor",{get:function(){var e="#808080";if(!this.state.isHidden&&this.modelCell){var t=this.getTagRefs(["superposition-visual","superposition-ligand-visual"]),r=t["superposition-ligand-visual"]?t["superposition-ligand-visual"]:t["superposition-visual"]?t["superposition-visual"]:void 0;if(r){var n=this.plugin.state.data.cells.get(r);if(n.params&&n.params.values&&n.params.values.colorTheme){var i=n.params.values.colorTheme;if(i.params&&i.params.value)e=""+v.Color.toStyle(i.params.value);else if(i.params&&i.params.palette){var a=i.params.palette.params.list.colors;e=""+v.Color.toStyle(a[0])}else if(i.params&&i.params.list){var o=i.params.list.colors;e=""+v.Color.toStyle(o[0])}}}}return e},enumerable:!1,configurable:!0}),t.prototype.render=function(){var e=this.customState.initParams.superpositionParams,t=this.props.structure.pdb_id+"_"+this.props.structure.struct_asym_id,r=this.customState.superpositionState.invalidStruct.indexOf(t)>-1,n=this.customState.superpositionState.noMatrixStruct.indexOf(t)>-1,a=r?n?" Matrix not available!":" No Ligand found!":this.getSubtitle(),o=this.props.structure.pdb_id+" chain "+this.props.structure.auth_asym_id;e&&e.ligandView&&(o=this.props.structure.pdb_id+" "+this.props.structure.struct_asym_id);var s=i.createElement(c.Button,{className:"msp-btn-tree-label",style:{borderLeftColor:this.panelColor},noOverflow:!0,title:o,disabled:!!(r||this.state.isBusy||this.state.isProcessing),onMouseEnter:this.highlight,onMouseLeave:this.clearHighlight},i.createElement("span",null,o),a&&i.createElement("small",null,a)),u=i.createElement(c.IconButton,{svg:this.state.showControls?h.ArrowDropDownSvg:h.ArrowRightSvg,flex:"20px",onClick:this.toggleControls,transparent:!0,className:"msp-no-hover-outline",disabled:!!(r||this.state.isBusy||this.state.isProcessing)}),l=i.createElement(c.IconButton,{svg:this.state.isHidden?h.VisibilityOffOutlinedSvg:h.VisibilityOutlinedSvg,toggleState:!1,small:!0,onClick:this.toggleVisible,disabled:!!(r||this.state.isBusy||this.state.isProcessing),title:this.state.isHidden?"Show chain":"Hide chain"}),d=i.createElement("div",{className:"msp-flex-row msp-tree-row",style:{marginLeft:this.state.isHidden?"31px":"10px"}},!this.state.isHidden&&u,s,l);return i.createElement("div",{style:{marginBottom:"1px"}},d,this.state.showControls&&this.updates())},t}(u.PluginUIComponent),O=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.toggleVisible=function(e){e.preventDefault(),e.currentTarget.blur();var r=t.props.representation.cell;o.PluginCommands.State.ToggleVisibility(t.plugin,{state:r.parent,ref:r.transform.parent})},t}return n.__extends(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.state.events.cell.stateUpdated,(function(t){s.State.ObjectEvent.isCell(t,e.props.representation.cell)&&e.forceUpdate()}))},t.prototype.render=function(){var e,t,r,n,a,o,s,u=this.props.representation.cell,l=null===(e=u.obj)||void 0===e?void 0:e.label;if((null===(t=u.obj)||void 0===t?void 0:t.data.source)&&(null===(r=u.obj)||void 0===r?void 0:r.data.source.label)){var d=(null===(n=u.obj)||void 0===n?void 0:n.data.source.label.indexOf("[Focus]"))>=0?"[Focus]":null===(a=u.obj)||void 0===a?void 0:a.data.source.label,f=d.length>10;d=""+(f?d.substring(0,28)+"...":d),l=f?d:d+" "+(l&&l.length<21?" - "+l:"")}return(null===(o=u.obj)||void 0===o?void 0:o.data.source)&&"Custom Selection"===(null===(s=u.obj)||void 0===s?void 0:s.data.source.label)&&(l="Custom Selection"),i.createElement("div",{className:"msp-representation-entry"},u.parent&&i.createElement(c.ExpandGroup,{header:""+(l||"Representation"),noOffset:!0,headerStyle:{overflow:"hidden"}},i.createElement(m.UpdateTransformControl,{state:u.parent,transform:u.transform,customHeader:"none",noMargin:!0})),i.createElement(c.IconButton,{svg:this.props.representation.cell.state.isHidden?h.VisibilityOffOutlinedSvg:h.VisibilityOutlinedSvg,toggleState:!1,onClick:this.toggleVisible,title:this.props.representation.cell.state.isHidden?"Show representation":"Hide representation",small:!0,className:"msp-default-bg",style:{position:"absolute",top:0,right:0,lineHeight:"24px",height:"24px",textAlign:"right",width:"32px",paddingRight:"6px",background:"none"}}))},t}(u.PurePluginUIComponent)},function(e,t,r){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.CustomEvents=void 0;var n=r(413);!function(e){function t(e,t,r){void 0!==t&&(t.residueNumber=t.seq_id,e.eventData=t,e.eventData.residueNumber=t.seq_id,r.dispatchEvent(e))}e.add=function(e,r){var i=function(e){for(var t={},r=0,n=e.length;r<n;r++){var i=e[r],a=void 0;"function"==typeof MouseEvent?a=new MouseEvent(i,{view:window,bubbles:!0,cancelable:!0}):"function"==typeof document.createEvent&&(a=document.createEvent("MouseEvents")).initEvent(i,!0,!0),t[i]=a}return t}(["PDB.molstar.click","PDB.molstar.mouseover","PDB.molstar.mouseout"]);e.behaviors.interaction.click.subscribe((function(e){if(1===e.button&&e.current&&"empty-loci"!==e.current.loci.kind){var a=n.lociDetails(e.current.loci);a&&t(i["PDB.molstar.click"],a,r)}})),e.behaviors.interaction.hover.subscribe((function(e){if(e.current&&e.current.loci&&"empty-loci"!==e.current.loci.kind){var a=n.lociDetails(e.current.loci);a&&t(i["PDB.molstar.mouseover"],a,r)}e.current&&e.current.loci&&"empty-loci"===e.current.loci.kind&&t(i["PDB.molstar.mouseout"],{},r)}))}}(t.CustomEvents||(t.CustomEvents={}))},function(e,t,r){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.SuperpositionFocusRepresentation=t.SuperpositionFocusRepresentationTags=void 0;var n,i=r(0),a=r(4),o=r(167),s=r(31),u=r(177),c=r(10),l=r(13),d=r(2),f=r(27),p=r(413);!function(e){e.SurrSel="superposition-focus-surr-sel",e.SurrRepr="superposition-focus-surr-repr"}(n=t.SuperpositionFocusRepresentationTags||(t.SuperpositionFocusRepresentationTags={}));var m=new Set([n.SurrSel,n.SurrRepr]),h=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return i.__extends(t,e),Object.defineProperty(t.prototype,"surrLabel",{get:function(){return"[Focus] Surroundings ("+this.params.expandRadius+" Å)"},enumerable:!1,configurable:!0}),t.prototype.ensureShape=function(e){var t=this.plugin.state.data,r=t.tree,i=t.build(),a=l.StateSelection.findUniqueTagsInSubtree(r,e.transform.ref,m);return a[n.SurrSel]||(a[n.SurrSel]=i.to(e).apply(s.StateTransforms.Model.StructureSelectionFromExpression,{expression:c.MolScriptBuilder.struct.generator.empty(),label:this.surrLabel},{tags:n.SurrSel}).ref),a[n.SurrRepr]||(a[n.SurrRepr]=i.to(a[n.SurrSel]).apply(s.StateTransforms.Representation.StructureRepresentation3D,this.params.surroundingsParams,{tags:n.SurrRepr}).ref),{state:t,builder:i,refs:a}},t.prototype.clear=function(e){var t=this.plugin.state.data,r=t.select(l.StateSelection.Generators.byRef(e).subtree().withTag(n.SurrSel));if(0!==r.length){for(var a=t.build(),o=c.MolScriptBuilder.struct.generator.empty(),u=0,d=r;u<d.length;u++){var p=d[u];a.to(p).update(s.StateTransforms.Model.StructureSelectionFromExpression,(function(e){return i.__assign(i.__assign({},e),{expression:o})}))}return f.PluginCommands.State.Update(this.plugin,{state:t,tree:a,options:{doNotLogTiming:!0,doNotUpdateCurrent:!0}})}},t.prototype.focus=function(e){return i.__awaiter(this,void 0,void 0,(function(){var t,r,o,u,l,d,m,h,g,v,b=this;return i.__generator(this,(function(y){switch(y.label){case 0:return(t=this.plugin.helpers.substructureParent.get(e.structure))&&t.obj?(r=a.StructureElement.Loci.remap(e,t.obj.data),o=a.StructureElement.Loci.extendToWholeResidues(r),u=a.StructureElement.Bundle.fromLoci(o),l=a.StructureElement.Bundle.toExpression(u),d=c.MolScriptBuilder.struct.modifier.includeSurroundings({0:l,radius:this.params.expandRadius,"as-whole-residues":!0}),p.lociDetails(e)||(d=c.MolScriptBuilder.struct.modifier.exceptBy({0:d,by:l})),m=this.ensureShape(t),h=m.state,g=m.builder,v=m.refs,g.to(v[n.SurrSel]).update(s.StateTransforms.Model.StructureSelectionFromExpression,(function(e){return i.__assign(i.__assign({},e),{expression:d,label:b.surrLabel})})),[4,f.PluginCommands.State.Update(this.plugin,{state:h,tree:g,options:{doNotLogTiming:!0,doNotUpdateCurrent:!0}})]):[2];case 1:return y.sent(),[2]}}))}))},t.prototype.register=function(e){var t=this;this.subscribeObservable(this.plugin.managers.structure.focus.behaviors.current,(function(e){t.clear(l.StateTransform.RootRef),e&&t.focus(e.loci)}))},t.prototype.update=function(e){return i.__awaiter(this,void 0,void 0,(function(){var t,r,a,o,s,u,c;return i.__generator(this,(function(i){switch(i.label){case 0:for(t=this.params,this.params=e,r=this.plugin.state.data,a=r.build(),o=l.StateSelection.Generators.root.subtree(),s=0,u=r.select(o.withTag(n.SurrRepr));s<u.length;s++)c=u[s],a.to(c).update(this.params.surroundingsParams);return[4,f.PluginCommands.State.Update(this.plugin,{state:r,tree:a,options:{doNotLogTiming:!0,doNotUpdateCurrent:!0}})];case 1:return i.sent(),e.expandRadius===t.expandRadius?[3,3]:[4,this.clear(l.StateTransform.RootRef)];case 2:i.sent(),i.label=3;case 3:return[2,!0]}}))}))},t}(u.PluginBehavior.WithSubscribers);t.SuperpositionFocusRepresentation=u.PluginBehavior.create({name:"create-superposition-focus-representation",display:{name:"Superposition Focus Representation"},category:"interaction",ctor:h,params:function(e,t){return function(e){var t=s.StateTransforms.Representation.StructureRepresentation3D.definition.params(void 0,e);return{expandRadius:d.ParamDefinition.Numeric(5,{min:1,max:10,step:1}),surroundingsParams:d.ParamDefinition.Group(t,{label:"Surroundings",customDefault:o.createStructureRepresentationParams(e,void 0,{type:"ball-and-stick",size:"physical",typeParams:{sizeFactor:.16},sizeParams:{scale:.3}})})}}(t)}})},function(e,t,r){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.SuperpostionViewport=void 0;var n=r(0),i=n.__importStar(r(3)),a=r(33),o=r(278),s=r(387),u=r(401),c=r(329),l=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return n.__extends(t,e),t.prototype.render=function(){var e,t,r=(null===(t=null===(e=this.plugin.spec.components)||void 0===e?void 0:e.viewport)||void 0===t?void 0:t.controls)||c.ViewportControls;return i.createElement(i.Fragment,null,i.createElement(c.Viewport,null),i.createElement("div",{className:"msp-viewport-top-left-controls"},i.createElement(o.StateSnapshotViewportControls,null)),i.createElement(o.SelectionViewportControls,null),i.createElement(r,null),i.createElement(s.BackgroundTaskProgress,null),i.createElement("div",{className:"msp-highlight-toast-wrapper"},i.createElement(o.LociLabels,null),i.createElement(u.Toasts,null)))},t}(a.PluginUIComponent);t.SuperpostionViewport=l},function(e,t,r){},function(e,t,r){"use strict";r.r(t),r.d(t,"PluginContext",(function(){return Lc}));var n,i,a,o=r(0),s=r(158),u=r(102),c=r(247),l=r(146),d=r(2);i=n||(n={}),a=function(){function e(){this.providers=Object(u.OrderedMap)().asMutable(),this.defaultAutoAttachValues=new Map}return e.prototype.getParams=function(e){var t={},r=[],n=[];if(e)for(var i=this.providers.values();;){var a=i.next();if(a.done)break;var s=a.value;s.isApplicable(e)&&(s.isHidden||(r.push([s.descriptor.name,s.label]),this.defaultAutoAttachValues.get(s.descriptor.name)&&n.push(s.descriptor.name)),t[s.descriptor.name]=d.ParamDefinition.Group(Object(o.__assign)({},s.getParams(e)),{label:s.label,isHidden:s.isHidden}))}return{autoAttach:d.ParamDefinition.MultiSelect(n,r),properties:d.ParamDefinition.Group(t,{isFlat:!0})}},e.prototype.setDefaultAutoAttach=function(e,t){this.defaultAutoAttachValues.set(e,t)},e.prototype.get=function(e){if(!this.providers.get(e))throw new Error("Custom property '"+e+"' is not registered.");return this.providers.get(e)},e.prototype.register=function(e,t){this.providers.set(e.descriptor.name,e),this.defaultAutoAttachValues.set(e.descriptor.name,t)},e.prototype.unregister=function(e){this.providers.delete(e),this.defaultAutoAttachValues.delete(e)},e}(),i.Registry=a;var f=r(296),p=["gz","zip"],m=["bcif","ccp4","dcd"];var h=function(){function e(e){this.plugin=e}return Object.defineProperty(e.prototype,"dataState",{get:function(){return this.plugin.state.data},enumerable:!1,configurable:!0}),e.prototype.rawData=function(e,t){return this.dataState.build().toRoot().apply(f.RawData,e,t).commit({revertOnError:!0})},e.prototype.download=function(e,t){return this.dataState.build().toRoot().apply(f.Download,e,t).commit({revertOnError:!0})},e.prototype.downloadBlob=function(e,t){return this.dataState.build().toRoot().apply(f.DownloadBlob,e,t).commit({revertOnError:!0})},e.prototype.readFile=function(e,t){var r;return Object(o.__awaiter)(this,void 0,void 0,(function(){var n,i;return Object(o.__generator)(this,(function(a){switch(a.label){case 0:return[4,this.dataState.build().toRoot().apply(f.ReadFile,e,t).commit({revertOnError:!0})];case 1:return n=a.sent(),i=function(e){var t,r,n="",i=(t=e instanceof File?e.name:e instanceof Blob?"":e).lastIndexOf("?"),a=-1!==i?t.substring(i):"",o=(t=t.substring(0,-1===i?t.length:i)).replace(/^.*[\\/]/,""),s=o.substring(0,o.lastIndexOf(".")),u=o.split("."),c=u.length>1?(u.pop()||"").toLowerCase():"",l=t.match(/^(.+):\/\/(.+)$/);l&&(n=l[1].toLowerCase(),t=l[2]||"");var d=t.substring(0,t.lastIndexOf("/")+1);if(p.includes(c)){r=c;var f=t.length-c.length-1;c=(t.substr(0,f).split(".").pop()||"").toLowerCase();var h=s.length-c.length-1;s=s.substr(0,h)}else r=!1;return{path:t,name:o,ext:c,base:s,dir:d,compressed:r,binary:m.includes(c),protocol:n,query:a,src:e}}((null===(r=e.file)||void 0===r?void 0:r.file)||""),[2,{data:n,fileInfo:i}]}}))}))},e}(),g=r(13),v=r(8),b=r(31),y=r(12),_=r(17),S=r(48),x=r(87),O=r(167),w=r(206),C=r(220),j=r(29),P=r(78),E=function(){function e(e){var t=this;this.plugin=e,this._providers=[],this.providerMap=new Map,this.defaultProvider=C.a.auto,Object(x.c)(C.a,(function(e){return t.registerPreset(e)}))}return Object.defineProperty(e.prototype,"dataState",{get:function(){return this.plugin.state.data},enumerable:!1,configurable:!0}),e.prototype.resolveProvider=function(e){var t;return"string"==typeof e?null!==(t=C.a[e])&&void 0!==t?t:Object(y.c)(this._providers,(function(t){return t.id===e})):e},e.prototype.hasPreset=function(e){for(var t=0,r=this._providers;t<r.length;t++){var n=r[t];if(!n.isApplicable||n.isApplicable(e,this.plugin))return!0}return!1},Object.defineProperty(e.prototype,"providers",{get:function(){return this._providers},enumerable:!1,configurable:!0}),e.prototype.getPresets=function(e){if(!e)return this.providers;for(var t=[],r=0,n=this._providers;r<n.length;r++){var i=n[r];i.isApplicable&&!i.isApplicable(e,this.plugin)||t.push(i)}return t},e.prototype.getPresetSelect=function(e){for(var t=[],r=0,n=this._providers;r<n.length;r++){var i=n[r];e&&i.isApplicable&&!i.isApplicable(e,this.plugin)||t.push([i.id,i.display.name,i.display.group])}return d.ParamDefinition.Select("auto",t)},e.prototype.getPresetsWithOptions=function(e){for(var t=[],r=Object.create(null),n=0,i=this._providers;n<i.length;n++){var a=i[n];a.isApplicable&&!a.isApplicable(e,this.plugin)||(t.push([a.id,a.display.name]),r[a.id]=a.params?d.ParamDefinition.Group(a.params(e,this.plugin)):d.ParamDefinition.EmptyGroup())}return 0===t.length?d.ParamDefinition.MappedStatic("",{"":d.ParamDefinition.EmptyGroup()}):d.ParamDefinition.MappedStatic(t[0][0],r,{options:t})},e.prototype.registerPreset=function(e){if(this.providerMap.has(e.id))throw new Error("Representation provider with id '"+e.id+"' already registered.");this._providers.push(e),this.providerMap.set(e.id,e)},e.prototype.unregisterPreset=function(e){this.providerMap.delete(e.id),Object(j.arrayRemoveInPlace)(this._providers,e)},e.prototype.applyPreset=function(e,t,r){var n,i=this,a=this.resolveProvider(t);if(a){var o=this.plugin.state.data,s=g.StateObjectRef.resolveAndCheck(o,e);if(s){var u=(null===(n=a.params)||void 0===n?void 0:n.call(a,s.obj,this.plugin))||{},c=r||(a.params?d.ParamDefinition.getDefaultValues(u):{}),l=this.plugin.config.get(P.PluginConfig.Structure.DefaultRepresentationPresetParams);c=d.ParamDefinition.merge(u,l,c);var f=_.b.create(""+a.display.name,(function(){return a.apply(s,c,i.plugin)}));return this.plugin.runTask(f)}S.b||console.warn("Applying structure repr. provider to bad cell.")}},e.prototype.addRepresentation=function(e,t,r){return Object(o.__awaiter)(this,void 0,void 0,(function(){var n,i;return Object(o.__generator)(this,(function(a){switch(a.label){case 0:return n=this.dataState.build(),(i=this.buildRepresentation(n,e,t,r))?[4,n.commit()]:[2];case 1:return a.sent(),[2,i]}}))}))},e.prototype.buildRepresentation=function(e,t,r,n){var i,a;if(t){var o=null===(a=null===(i=g.StateObjectRef.resolveAndCheck(this.dataState,t))||void 0===i?void 0:i.obj)||void 0===a?void 0:a.data;if(o){var s=Object(O.createStructureRepresentationParams)(this.plugin,o,r);return(null==n?void 0:n.tag)?e.to(t).applyOrUpdateTagged(n.tag,w.StructureRepresentation3D,s,{state:null==n?void 0:n.initialState}).selector:e.to(t).apply(w.StructureRepresentation3D,s,{state:null==n?void 0:n.initialState}).selector}}},e}(),A=r(4),D=r(95),T=r(9),I=r(275),M=r(1),k=r(160),B=r(257);function V(e){return e}(V||(V={})).CommonParams=function(e,t){return{modelProperties:d.ParamDefinition.Optional(d.ParamDefinition.Group(g.StateTransformer.getParamDefinition(b.StateTransforms.Model.CustomModelProperties,void 0,t))),structureProperties:d.ParamDefinition.Optional(d.ParamDefinition.Group(g.StateTransformer.getParamDefinition(b.StateTransforms.Model.CustomStructureProperties,void 0,t))),representationPreset:d.ParamDefinition.Optional(d.ParamDefinition.Text("auto"))}};var R=V.CommonParams,L=V({id:"preset-trajectory-default",display:{name:"Default (Assembly)",group:"Preset",description:"Shows the first assembly or, if 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u=o.sent(),void 0===t.showUnitcell||t.showUnitcell?[4,n.tryCreateUnitcell(a,void 0,{isHidden:!0})]:[3,6];case 5:return l=o.sent(),[3,7];case 6:l=void 0,o.label=7;case 7:return c=l,[4,r.builders.structure.representation.applyPreset(u,t.representationPreset||"auto",t.representationPresetParams)];case 8:return d=o.sent(),[2,{model:i,modelProperties:a,unitcell:c,structure:s,structureProperties:u,representation:d}]}}))}))}}),N=V({id:"preset-trajectory-all-models",display:{name:"All Models",group:"Preset",description:"Shows all models; colored by model-index."},isApplicable:function(e){return e.data.frameCount>1},params:function(e,t){return Object(o.__assign)({useDefaultIfSingleModel:d.ParamDefinition.Optional(d.ParamDefinition.Boolean(!1)),representationPresetParams:d.ParamDefinition.Optional(d.ParamDefinition.Group(C.b.CommonParams))},R(e,t))},apply:function(e,t,r){var n,i;return Object(o.__awaiter)(this,void 0,void 0,(function(){var a,s,u,c,l,d,f,p,m,h;return Object(o.__generator)(this,(function(o){switch(o.label){case 0:if(!(a=null===(i=null===(n=g.StateObjectRef.resolveAndCheck(r.state.data,e))||void 0===n?void 0:n.obj)||void 0===i?void 0:i.data))return[2,{}];if(1===a.frameCount&&t.useDefaultIfSingleModel)return[2,L.apply(e,t,r)];s=r.builders.structure,u=[],c=[],l=0,o.label=1;case 1:return l<a.frameCount?[4,s.createModel(e,{modelIndex:l})]:[3,8];case 2:return d=o.sent(),[4,s.insertModelProperties(d,t.modelProperties,{isCollapsed:!0})];case 3:return f=o.sent(),[4,s.createStructure(f||d,{name:"model",params:{}})];case 4:return p=o.sent(),[4,s.insertStructureProperties(p,t.structureProperties)];case 5:return m=o.sent(),u.push(d),c.push(p),h=p.obj?Object(k.c)(p.obj.data,{elementCountFactor:a.frameCount}):"medium",[4,s.representation.applyPreset(m,t.representationPreset||"auto",{theme:{globalName:"model-index"},quality:h})];case 6:o.sent(),o.label=7;case 7:return l++,[3,1];case 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d=o.sent(),[2,{model:a,modelProperties:s,unitcell:l,structure:u,structureProperties:c,representation:d}]}}))}))}var z,H,G=V({id:"preset-trajectory-unitcell",display:{name:"Unit Cell",group:"Preset",description:"Shows the fully populated unit cell."},isApplicable:function(e){return A.Model.hasCrystalSymmetry(e.data.representative)},params:F,apply:function(e,t,r){return Object(o.__awaiter)(this,void 0,void 0,(function(){return Object(o.__generator)(this,(function(n){switch(n.label){case 0:return[4,U({ijkMin:M.Vec3.create(0,0,0),ijkMax:M.Vec3.create(0,0,0)},e,t,r)];case 1:return[2,n.sent()]}}))}))}}),q=V({id:"preset-trajectory-supercell",display:{name:"Super Cell",group:"Preset",description:"Shows the super cell, i.e. the central unit cell and all adjacent unit cells."},isApplicable:function(e){return A.Model.hasCrystalSymmetry(e.data.representative)},params:F,apply:function(e,t,r){return Object(o.__awaiter)(this,void 0,void 0,(function(){return Object(o.__generator)(this,(function(n){switch(n.label){case 0:return[4,U({ijkMin:M.Vec3.create(-1,-1,-1),ijkMax:M.Vec3.create(1,1,1),theme:"operator-hkl"},e,t,r)];case 1:return[2,n.sent()]}}))}))}}),W=V({id:"preset-trajectory-crystal-contacts",display:{name:"Crystal Contacts",group:"Preset",description:"Showsasymetric unit and chains from neighbours within 5 Å, i.e., symmetry mates."},isApplicable:function(e){return A.Model.hasCrystalSymmetry(e.data.representative)},params:function(e,t){return Object(o.__assign)({model:d.ParamDefinition.Optional(d.ParamDefinition.Group(g.StateTransformer.getParamDefinition(b.StateTransforms.Model.ModelFromTrajectory,e,t)))},R(e,t))},apply:function(e,t,r){return Object(o.__awaiter)(this,void 0,void 0,(function(){var n,i,a,s,u,c,l;return Object(o.__generator)(this,(function(o){switch(o.label){case 0:return[4,(n=r.builders.structure).createModel(e,t.model)];case 1:return i=o.sent(),[4,n.insertModelProperties(i,t.modelProperties)];case 2:return a=o.sent(),[4,n.createStructure(a||i,{name:"symmetry-mates",params:{radius:5}})];case 3:return s=o.sent(),[4,n.insertStructureProperties(s,t.structureProperties)];case 4:return u=o.sent(),[4,n.tryCreateUnitcell(a,void 0,{isHidden:!0})];case 5:return c=o.sent(),[4,r.builders.structure.representation.applyPreset(u,t.representationPreset||"auto",{theme:{globalName:"operator-name",carbonColor:"operator-name",focus:{name:"element-symbol",params:{carbonColor:{name:"operator-name",params:B.c.defaultValues}}}}})];case 6:return l=o.sent(),[2,{model:i,modelProperties:a,unitcell:c,structure:s,structureProperties:u,representation:l}]}}))}))}}),X={default:L,"all-models":N,unitcell:G,supercell:q,crystalContacts:W},Y=function(){function e(e){var t=this;this.plugin=e,this._providers=[],this.providerMap=new Map,this.defaultProvider=X.default,Object(x.c)(X,(function(e){return t.registerPreset(e)}))}return e.prototype.resolveProvider=function(e){var t;return"string"==typeof e?null!==(t=X[e])&&void 0!==t?t:Object(y.c)(this._providers,(function(t){return t.id===e})):e},e.prototype.hasPreset=function(e){for(var t=0,r=this._providers;t<r.length;t++){var n=r[t];if(!n.isApplicable||n.isApplicable(e,this.plugin))return!0}return!1},Object.defineProperty(e.prototype,"providers",{get:function(){return this._providers},enumerable:!1,configurable:!0}),e.prototype.getPresets=function(e){if(!e)return this.providers;for(var t=[],r=0,n=this._providers;r<n.length;r++){var i=n[r];i.isApplicable&&!i.isApplicable(e,this.plugin)||t.push(i)}return t},e.prototype.getPresetSelect=function(e){for(var t=[],r=0,n=this._providers;r<n.length;r++){var i=n[r];e&&i.isApplicable&&!i.isApplicable(e,this.plugin)||t.push([i.id,i.display.name])}return d.ParamDefinition.Select("auto",t)},e.prototype.getPresetsWithOptions=function(e){for(var t=[],r=Object.create(null),n=0,i=this._providers;n<i.length;n++){var a=i[n];a.isApplicable&&!a.isApplicable(e,this.plugin)||(t.push([a.id,a.display.name]),r[a.id]=a.params?d.ParamDefinition.Group(a.params(e,this.plugin)):d.ParamDefinition.EmptyGroup())}return 0===t.length?d.ParamDefinition.MappedStatic("",{"":d.ParamDefinition.EmptyGroup()}):d.ParamDefinition.MappedStatic(t[0][0],r,{options:t})},e.prototype.registerPreset=function(e){if(this.providerMap.has(e.id))throw new Error("Hierarchy provider with id '"+e.id+"' already registered.");this._providers.push(e),this.providerMap.set(e.id,e)},e.prototype.unregisterPreset=function(e){this.providerMap.delete(e.id),Object(j.arrayRemoveInPlace)(this._providers,e)},e.prototype.applyPreset=function(e,t,r){var n=this,i=this.resolveProvider(t);if(i){var a=this.plugin.state.data,o=g.StateObjectRef.resolveAndCheck(a,e);if(o){var s=r||(i.params?d.ParamDefinition.getDefaultValues(i.params(o.obj,this.plugin)):{}),u=_.b.create(""+i.display.name,(function(){return i.apply(o,s,n.plugin)}));return 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oe=Object(Z.a)({label:"CCP4/MRC/MAP",description:"CCP4/MRC/MAP",category:"Volume",binaryExtensions:["ccp4","mrc","map"],parse:function(e,t,r){return Object(o.__awaiter)(void 0,void 0,void 0,(function(){var n,i;return Object(o.__generator)(this,(function(a){switch(a.label){case 0:return n=e.build().to(t).apply(b.StateTransforms.Data.ParseCcp4,{},{state:{isGhost:!0}}),i=n.apply(b.StateTransforms.Volume.VolumeFromCcp4,{entryId:null==r?void 0:r.entryId}),[4,n.commit({revertOnError:!0})];case 1:return a.sent(),[4,ne(e,i.selector.data)];case 2:return a.sent(),[2,{format:n.selector,volume:i.selector}]}}))}))},visuals:ae}),se=Object(Z.a)({label:"DSN6/BRIX",description:"DSN6/BRIX",category:"Volume",binaryExtensions:["dsn6","brix"],parse:function(e,t,r){return Object(o.__awaiter)(void 0,void 0,void 0,(function(){var n,i;return Object(o.__generator)(this,(function(a){switch(a.label){case 0:return n=e.build().to(t).apply(b.StateTransforms.Data.ParseDsn6,{},{state:{isGhost:!0}}),i=n.apply(b.StateTransforms.Volume.VolumeFromDsn6,{entryId:null==r?void 0:r.entryId}),[4,n.commit({revertOnError:!0})];case 1:return a.sent(),[4,ne(e,i.selector.data)];case 2:return a.sent(),[2,{format:n.selector,volume:i.selector}]}}))}))},visuals:ae}),ue=Object(Z.a)({label:"DX",description:"DX",category:"Volume",stringExtensions:["dx"],binaryExtensions:["dxbin"],parse:function(e,t,r){return Object(o.__awaiter)(void 0,void 0,void 0,(function(){var n,i;return Object(o.__generator)(this,(function(a){switch(a.label){case 0:return n=e.build().to(t).apply(b.StateTransforms.Data.ParseDx,{},{state:{isGhost:!0}}),[4,(i=n.apply(b.StateTransforms.Volume.VolumeFromDx,{entryId:null==r?void 0:r.entryId})).commit({revertOnError:!0})];case 1:return a.sent(),[4,ne(e,i.selector.data)];case 2:return a.sent(),[2,{volume:i.selector}]}}))}))},visuals:ae}),ce=[["ccp4",oe],["dsn6",se],["cube",Object(Z.a)({label:"Cube",description:"Cube",category:"Volume",stringExtensions:["cub","cube"],parse:function(e,t,r){return Object(o.__awaiter)(void 0,void 0,void 0,(function(){var n,i,a;return Object(o.__generator)(this,(function(o){switch(o.label){case 0:return n=e.build().to(t).apply(b.StateTransforms.Data.ParseCube,{},{state:{isGhost:!0}}),i=n.apply(b.StateTransforms.Volume.VolumeFromCube,{entryId:null==r?void 0:r.entryId}),a=n.apply(b.StateTransforms.Model.TrajectoryFromCube,void 0,{state:{isGhost:!0}}).apply(b.StateTransforms.Model.ModelFromTrajectory).apply(b.StateTransforms.Model.StructureFromModel),[4,n.commit({revertOnError:!0})];case 1:return o.sent(),[4,ne(e,i.selector.data)];case 2:return o.sent(),[2,{format:n.selector,volume:i.selector,structure:a.selector}]}}))}))},visuals:function(e,t){return Object(o.__awaiter)(void 0,void 0,void 0,(function(){var r,n,i,a,s,u,c,l,d,f;return Object(o.__generator)(this,(function(p){switch(p.label){case 0:return r=e.build(),n=[],(i=null===(f=null===(d=t.volume.cell)||void 0===d?void 0:d.obj)||void 0===f?void 0:f.data)&&$.b.isOrbitals(i)?(a=r.to(t.volume).apply(b.StateTransforms.Representation.VolumeRepresentation3D,Object(ee.a)(e,i,{type:"isosurface",typeParams:{isoValue:$.b.IsoValue.relative(1),alpha:.4},color:"uniform",colorParams:{value:J.a.blue}})),s=r.to(t.volume).apply(b.StateTransforms.Representation.VolumeRepresentation3D,Object(ee.a)(e,i,{type:"isosurface",typeParams:{isoValue:$.b.IsoValue.relative(-1),alpha:.4},color:"uniform",colorParams:{value:J.a.red}})),n.push(a.selector,s.selector)):(u=r.to(t.volume).apply(b.StateTransforms.Representation.VolumeRepresentation3D,Object(ee.a)(e,i,{type:"isosurface",typeParams:{isoValue:$.b.IsoValue.relative(2),alpha:.4},color:"uniform",colorParams:{value:J.a.grey}})),n.push(u.selector)),[4,e.builders.structure.representation.applyPreset(t.structure,"auto")];case 1:return c=p.sent(),[4,r.commit()];case 2:return p.sent(),l=[],Object(x.c)(null==c?void 0:c.representations,(function(e){e&&l.push(e)})),[2,Object(o.__spreadArrays)(n,l)]}}))}))}})],["dx",ue],["dscif",Object(Z.a)({label:"DensityServer CIF",description:"DensityServer CIF",category:"Volume",stringExtensions:["cif"],binaryExtensions:["bcif"],isApplicable:function(e,t){return"dscif"===Object(Z.b)(e,t)},parse:function(e,t,r){return Object(o.__awaiter)(void 0,void 0,void 0,(function(){var n,i,a,s,u,c,l,d,f,p;return Object(o.__generator)(this,(function(o){switch(o.label){case 0:return[4,e.build().to(t).apply(b.StateTransforms.Data.ParseCif).commit()];case 1:if(n=o.sent(),i=e.build().to(n),1!==(a=n.obj.data.blocks.slice(1)).length&&2!==a.length)throw new Error("unknown number of blocks");for(s=[],u=0,c=a;u<c.length;u++)l=c[u],s.push(i.apply(b.StateTransforms.Volume.VolumeFromDensityServerCif,{blockHeader:l.header,entryId:null==r?void 0:r.entryId}).selector);return[4,i.commit()];case 2:o.sent(),d=0,f=s,o.label=3;case 3:return d<f.length?(p=f[d],[4,ne(e,p.data)]):[3,6];case 4:o.sent(),o.label=5;case 5:return d++,[3,3];case 6:return[2,{volumes:s}]}}))}))},visuals:function(e,t){return Object(o.__awaiter)(void 0,void 0,void 0,(function(){var r,n,i,a,s,u;return Object(o.__generator)(this,(function(o){switch(o.label){case 0:return r=t.volumes,n=e.build(),i=[],r.length>0&&(a=r[0].data&&ie(r[0].data)||$.b.IsoValue.relative(1.5),i[0]=n.to(r[0]).apply(b.StateTransforms.Representation.VolumeRepresentation3D,w.VolumeRepresentation3DHelpers.getDefaultParamsStatic(e,"isosurface",{isoValue:a,alpha:1},"uniform",{value:J.a.teal})).selector),r.length>1&&(s=w.VolumeRepresentation3DHelpers.getDefaultParamsStatic(e,"isosurface",{isoValue:$.b.IsoValue.relative(3),alpha:.3},"uniform",{value:J.a.green}),u=w.VolumeRepresentation3DHelpers.getDefaultParamsStatic(e,"isosurface",{isoValue:$.b.IsoValue.relative(-3),alpha:.3},"uniform",{value:J.a.red}),i[i.length]=n.to(r[1]).apply(b.StateTransforms.Representation.VolumeRepresentation3D,s).selector,i[i.length]=n.to(r[1]).apply(b.StateTransforms.Representation.VolumeRepresentation3D,u).selector),[4,n.commit()];case 1:return o.sent(),[2,i]}}))}))}})]],le=[["ply",Object(Z.a)({label:"PLY",description:"PLY",category:"Shape",stringExtensions:["ply"],parse:function(e,t){return Object(o.__awaiter)(void 0,void 0,void 0,(function(){var r,n;return Object(o.__generator)(this,(function(i){switch(i.label){case 0:return r=e.state.data.build().to(t).apply(b.StateTransforms.Data.ParsePly,{},{state:{isGhost:!0}}),n=r.apply(b.StateTransforms.Model.ShapeFromPly),[4,r.commit()];case 1:return i.sent(),[2,{format:r.selector,shape:n.selector}]}}))}))},visuals:function(e,t){return e.state.data.build().to(t.shape).apply(b.StateTransforms.Representation.ShapeRepresentation3D).commit()}})]],de=[["psf",Object(Z.a)({label:"PSF",description:"PSF",category:"Structure",stringExtensions:["psf"],parse:function(e,t){return Object(o.__awaiter)(void 0,void 0,void 0,(function(){var r,n;return Object(o.__generator)(this,(function(i){switch(i.label){case 0:return r=e.state.data.build().to(t).apply(b.StateTransforms.Data.ParsePsf,{},{state:{isGhost:!0}}),n=r.apply(b.StateTransforms.Model.TopologyFromPsf),[4,r.commit()];case 1:return i.sent(),[2,{format:r.selector,topology:n.selector}]}}))}))}})],["dcd",Object(Z.a)({label:"DCD",description:"DCD",category:"Structure",binaryExtensions:["dcd"],parse:function(e,t){return e.state.data.build().to(t).apply(b.StateTransforms.Model.CoordinatesFromDcd).commit()}})],["xtc",Object(Z.a)({label:"XTC",description:"XTC",category:"Structure",binaryExtensions:["xtc"],parse:function(e,t){return e.state.data.build().to(t).apply(b.StateTransforms.Model.CoordinatesFromXtc).commit()}})]],fe=function(){function e(){this._list=[],this._map=new Map,this._extensions=void 0,this._binaryExtensions=void 0,this._options=void 0;for(var e=0,t=ce;e<t.length;e++){var r=t[e],n=r[0],i=r[1];this.add(n,i)}for(var a=0,o=de;a<o.length;a++){var s=o[a];n=s[0],i=s[1];this.add(n,i)}for(var u=0,c=le;u<c.length;u++){var l=c[u];n=l[0],i=l[1];this.add(n,i)}for(var d=0,f=K.a;d<f.length;d++){var p=f[d];n=p[0],i=p[1];this.add(n,i)}}return Object.defineProperty(e.prototype,"types",{get:function(){return this._list.map((function(e){return[e.name,e.provider.label]}))},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"extensions",{get:function(){if(this._extensions)return this._extensions;var e=new Set;return this._list.forEach((function(t){var r,n,i=t.provider;null===(r=i.stringExtensions)||void 0===r||r.forEach((function(t){return e.add(t)})),null===(n=i.binaryExtensions)||void 0===n||n.forEach((function(t){return e.add(t)}))})),this._extensions=e,e},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"binaryExtensions",{get:function(){if(this._binaryExtensions)return this._binaryExtensions;var e=new Set;return this._list.forEach((function(t){var r;return null===(r=t.provider.binaryExtensions)||void 0===r?void 0:r.forEach((function(t){return e.add(t)}))})),this._binaryExtensions=e,e},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"options",{get:function(){if(this._options)return this._options;var e=[];return this._list.forEach((function(t){var r=t.name,n=t.provider;return e.push([r,n.label,n.category||""])})),this._options=e,e},enumerable:!1,configurable:!0}),e.prototype._clear=function(){this._extensions=void 0,this._binaryExtensions=void 0,this._options=void 0},e.prototype.add=function(e,t){this._clear(),this._list.push({name:e,provider:t}),this._map.set(e,t)},e.prototype.remove=function(e){this._clear(),this._list.splice(this._list.findIndex((function(t){return t.name===e})),1),this._map.delete(e)},e.prototype.auto=function(e,t){for(var r=0,n=this.list.length;r<n;++r){var i=this._list[r].provider,a=!1;if((i.binaryExtensions&&i.binaryExtensions.indexOf(e.ext)>=0||i.stringExtensions&&i.stringExtensions.indexOf(e.ext)>=0)&&(a=!0),a&&(!i.isApplicable||i.isApplicable(e,t.data)))return i}},e.prototype.get=function(e){if(this._map.has(e))return this._map.get(e);throw new Error("unknown data format name '"+e+"'")},Object.defineProperty(e.prototype,"list",{get:function(){return this._list},enumerable:!1,configurable:!0}),e}(),pe=r(89),me=r(23),he=r(128),ge={minRadius:5,extraRadius:4,durationMs:250},ve=function(){function e(e){this.plugin=e,this.boundaryHelper=new he.a("98")}return e.prototype.transformedLoci=function(e){var t,r;if(A.StructureElement.Loci.is(e)){var n=null===(r=null===(t=this.plugin.helpers.substructureParent.get(e.structure))||void 0===t?void 0:t.obj)||void 0===r?void 0:r.data;n&&(e=A.StructureElement.Loci.remap(e,n))}return e},e.prototype.focusRenderObjects=function(e,t){if(e){for(var r=[],n=0,i=e;n<i.length;n++){var a=i[n].values.boundingSphere.ref.value;0!==a.radius&&r.push(a)}this.focusSpheres(r,(function(e){return e}),t)}},e.prototype.focusLoci=function(e,t){var r;if(Array.isArray(e)&&e.length>1){for(var n=[],i=0,a=e;i<a.length;i++){var o=a[i];(c=me.Loci.getBoundingSphere(this.transformedLoci(o)))&&n.push(c)}if(0===n.length)return;this.boundaryHelper.reset();for(var s=0,u=n;s<u.length;s++){var c=u[s];this.boundaryHelper.includeSphere(c)}this.boundaryHelper.finishedIncludeStep();for(var l=0,d=n;l<d.length;l++){c=d[l];this.boundaryHelper.radiusSphere(c)}r=this.boundaryHelper.getSphere()}else if(Array.isArray(e)){if(0===e.length)return;r=me.Loci.getBoundingSphere(this.transformedLoci(e[0]))}else r=me.Loci.getBoundingSphere(this.transformedLoci(e));r&&this.focusSphere(r,t)},e.prototype.focusSpheres=function(e,t,r){for(var n=[],i=0,a=e;i<a.length;i++){(u=t(a[i]))&&n.push(u)}if(0!==n.length){if(1===n.length)return this.focusSphere(n[0],r);this.boundaryHelper.reset();for(var o=0,s=n;o<s.length;o++){var u=s[o];this.boundaryHelper.includeSphere(u)}this.boundaryHelper.finishedIncludeStep();for(var c=0,l=n;c<l.length;c++){u=l[c];this.boundaryHelper.radiusSphere(u)}this.focusSphere(this.boundaryHelper.getSphere(),r)}},e.prototype.focusSphere=function(e,t){var r,n,i,a,s=Object(o.__assign)(Object(o.__assign)({},ge),t),u=s.extraRadius,c=s.minRadius,l=s.durationMs,d=Math.max(e.radius+u,c);if(null==t?void 0:t.principalAxes){var f=null==t?void 0:t.principalAxes.boxAxes,p=f.origin,m=f.dirA,h=f.dirC,g=null===(r=this.plugin.canvas3d)||void 0===r?void 0:r.camera.getFocus(p,d,m,h);null===(n=this.plugin.canvas3d)||void 0===n||n.requestCameraReset({durationMs:l,snapshot:g})}else{g=null===(i=this.plugin.canvas3d)||void 0===i?void 0:i.camera.getFocus(e.center,d);null===(a=this.plugin.canvas3d)||void 0===a||a.requestCameraReset({durationMs:l,snapshot:g})}},e.prototype.setSnapshot=function(e,t){var r;null===(r=this.plugin.canvas3d)||void 0===r||r.requestCameraReset({snapshot:e,durationMs:t})},e.prototype.reset=function(e,t){var r;null===(r=this.plugin.canvas3d)||void 0===r||r.requestCameraReset({snapshot:e,durationMs:t})},e}(),be=r(380),ye=r(41),_e=r(51),Se=function(){function e(e){var t=this;this.ctx=e,this.providers=[],this.locis=[],this.isDirty=!1,this.labels=[],this.groupedLabels=new Map,e.managers.interactivity.lociHighlights.addProvider((function(e,r){t.mark(e,r),t.showLabels()}))}return e.prototype.clearProviders=function(){this.providers=[],this.isDirty=!0,this.showLabels()},e.prototype.addProvider=function(e){this.providers.push(e),this.providers.sort((function(e,t){return(t.priority||0)-(e.priority||0)})),this.isDirty=!0,this.showLabels()},e.prototype.removeProvider=function(e){this.providers=this.providers.filter((function(t){return t!==e})),this.isDirty=!0,this.showLabels()},e.prototype.mark=function(e,t){var r=this.locis.findIndex((function(t){return ye.a.Loci.areEqual(e,t)}));-1===r&&t===_e.a.Highlight?(this.locis.push(e),this.isDirty=!0):-1!==r&&t===_e.a.RemoveHighlight&&(Object(j.arrayRemoveAtInPlace)(this.locis,r),this.isDirty=!0)},e.prototype.showLabels=function(){this.ctx.behaviors.labels.highlight.next({labels:this.getLabels()})},e.prototype.getLabels=function(){var e=this;if(this.isDirty){this.groupedLabels.clear(),this.labels.length=0;for(var t=0,r=this.providers;t<r.length;t++)for(var n=r[t],i=0,a=this.locis;i<a.length;i++){var o=a[i];if(!me.Loci.isEmpty(o.loci)){var s=n.label(o.loci,o.repr);if(s){var u=n.group?n.group(s):s.toString(),c=this.groupedLabels.get(u);c?c.push(s):this.groupedLabels.set(u,[s])}}}this.labels.length=0,this.groupedLabels.forEach((function(t,r){var n=t.length,i=n>1&&t[0]!==t[1]?r:t[0];e.labels.push(1===n?i:i+" <small>|| × "+n+"</small>")})),this.isDirty=!1}return this.labels},e}(),xe=r(260),Oe=r(116),we=r(77),Ce=function(e){function t(t){var r=e.call(this,{history:[]})||this;r.plugin=t,r.events={historyUpdated:r.ev()},r.behaviors={current:r.ev.behavior(void 0)},t.state.data.events.object.removed.subscribe((function(e){var t,n,i=e.obj;if(v.a.Molecule.Structure.is(i)){(null===(n=r.current)||void 0===n?void 0:n.loci.structure)===i.data&&r.clear();for(var a=[],o=0,s=r.history;o<s.length;o++){var u=s[o];u.loci.structure===i.data&&a.push(u)}a.length!==r.history.length&&(r.history.length=0,(t=r.history).push.apply(t,a),r.events.historyUpdated.next())}}));var n=Object(T.g)();return t.state.data.events.object.updated.subscribe((function(e){var t,i=e.oldData,a=e.obj,s=e.action;if(v.a.Molecule.Structure.is(a)&&"in-place"===s){var u=r.state.current,c=a.data;if(u&&u.loci.structure===i){var l=A.StructureElement.Loci.remap(u.loci,c);r.state.current=Object(o.__assign)(Object(o.__assign)({},u),{loci:l}),r.behaviors.current.next(r.state.current),me.Loci.getBoundingSphere(l,n);var d=null===(t=r.plugin.canvas3d)||void 0===t?void 0:t.camera,f=d.getTargetDistance(n.radius+4);(M.Vec3.distance(d.target,n.center)>n.radius||f>d.viewport.height/d.zoom)&&r.plugin.managers.camera.focusSphere(n,{durationMs:0})}}})),r}return Object(o.__extends)(t,e),Object.defineProperty(t.prototype,"current",{get:function(){return this.state.current},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"history",{get:function(){return this.state.history},enumerable:!1,configurable:!0}),t.prototype.tryAddHistory=function(e){if(!A.StructureElement.Loci.isEmpty(e.loci)){for(var t=0,r=void 0,n=0,i=this.state.history;n<i.length;n++){var a=i[n];if(A.StructureElement.Loci.areEqual(a.loci,e.loci)){r=a;break}t++}if(r)return Object(j.arrayRemoveAtInPlace)(this.state.history,t),this.state.history.unshift(e),void this.events.historyUpdated.next();this.state.history.unshift(e),this.state.history.length>8&&this.state.history.pop(),this.events.historyUpdated.next()}},t.prototype.set=function(e){this.tryAddHistory(e),this.state.current&&A.StructureElement.Loci.areEqual(this.state.current.loci,e.loci)||(this.state.current=e,this.behaviors.current.next(e))},t.prototype.setFromLoci=function(e){var t=me.Loci.normalize(e);A.StructureElement.Loci.is(t)&&!A.StructureElement.Loci.isEmpty(t)?this.set({loci:t,label:Object(we.lociLabel)(t,{reverse:!0,hidePrefix:!0,htmlStyling:!1})}):this.clear()},t.prototype.addFromLoci=function(e){var t=this.state.current&&A.StructureElement.Loci.is(e)&&e.structure===this.state.current.loci.structure?A.StructureElement.Loci.union(e,this.state.current.loci):e;this.setFromLoci(t)},t.prototype.clear=function(){this.state.current&&(this.state.current=void 0,this.behaviors.current.next(void 0))},t.prototype.getSnapshot=function(){if(!this.current)return{};var e=this.plugin.helpers.substructureParent.get(this.current.loci.structure),t=null==e?void 0:e.transform.ref;return t?{current:{label:this.current.label,ref:t,bundle:A.StructureElement.Bundle.fromLoci(this.current.loci),category:this.current.category}}:{}},t.prototype.setSnapshot=function(e){var t,r;if(e.current){var n=e.current,i=n.label,a=n.ref,o=n.bundle,s=n.category,u=null===(r=null===(t=this.plugin.state.data.select(g.StateSelection.Generators.byRef(a))[0])||void 0===t?void 0:t.obj)||void 0===r?void 0:r.data;if(u){var c=A.StructureElement.Bundle.toLoci(o,u);this.set({label:i,loci:c,category:s})}}else this.clear()},t}(Oe.b),je=r(284),Pe=r(379),Ee=r(6),Ae=r(238),De=r(5),Te=new he.a("98"),Ie=function(e){function t(t){var r=e.call(this,{entries:new Map,additionsHistory:[],stats:{structureCount:0,elementCount:0,label:"Nothing Selected"}})||this;return r.plugin=t,r.events={changed:r.ev(),additionsHistoryUpdated:r.ev(),loci:{add:r.ev(),remove:r.ev(),clear:r.ev()}},t.helpers.substructureParent.events.removed.subscribe((function(e){return r.onRemove(e.ref,e.obj)})),t.helpers.substructureParent.events.updated.subscribe((function(e){return r.onUpdate(e.ref,e.oldObj,e.obj)})),r}return Object(o.__extends)(t,e),Object.defineProperty(t.prototype,"entries",{get:function(){return this.state.entries},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"additionsHistory",{get:function(){return this.state.additionsHistory},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"stats",{get:function(){return this.state.stats||(this.state.stats=this.calcStats()),this.state.stats},enumerable:!1,configurable:!0}),t.prototype.getEntry=function(e){var t=this.plugin.helpers.substructureParent.get(e,!0);if(t){var r=t.transform.ref;if(!this.entries.has(r)){var n=new Me(A.StructureElement.Loci(e,[]));return this.entries.set(r,n),n}return this.entries.get(r)}},t.prototype.calcStats=function(){var e=0,t=0,r=A.StructureElement.Stats.create();this.entries.forEach((function(n){var i=n.selection.elements;if(i.length){e+=1;for(var a=0,o=i.length;a<o;++a)t+=Ee.OrderedSet.size(i[a].indices);A.StructureElement.Stats.add(r,r,A.StructureElement.Stats.ofLoci(n.selection))}}));var n=Object(we.structureElementStatsLabel)(r,{countsOnly:!0});return{structureCount:e,elementCount:t,label:n}},t.prototype.add=function(e){if(!A.StructureElement.Loci.is(e))return!1;var t=this.getEntry(e.structure);if(!t)return!1;var r=t.selection;return t.selection=A.StructureElement.Loci.union(t.selection,e),this.tryAddHistory(e),this.referenceLoci=e,this.events.loci.add.next(e),!A.StructureElement.Loci.areEqual(r,t.selection)},t.prototype.remove=function(e){if(!A.StructureElement.Loci.is(e))return!1;var t=this.getEntry(e.structure);if(!t)return!1;var r=t.selection;return t.selection=A.StructureElement.Loci.subtract(t.selection,e),this.referenceLoci=e,this.events.loci.remove.next(e),!A.StructureElement.Loci.areEqual(r,t.selection)},t.prototype.intersect=function(e){if(!A.StructureElement.Loci.is(e))return!1;var t=this.getEntry(e.structure);if(!t)return!1;var r=t.selection;return t.selection=A.StructureElement.Loci.intersect(t.selection,e),this.referenceLoci=e,!A.StructureElement.Loci.areEqual(r,t.selection)},t.prototype.set=function(e){if(!A.StructureElement.Loci.is(e))return!1;var t=this.getEntry(e.structure);if(!t)return!1;var r=t.selection;return t.selection=e,this.tryAddHistory(e),this.referenceLoci=void 0,!A.StructureElement.Loci.areEqual(r,t.selection)},t.prototype.modifyHistory=function(e,t,r,n){void 0===n&&(n=!1);var i=this.additionsHistory,a=i.indexOf(e);if(!(a<0)){var o=void 0;switch(t){case"remove":Object(j.arrayRemoveAtInPlace)(i,a);break;case"up":o=a-1;break;case"down":o=a+1}if(void 0!==o)for(var s=r?Math.min(i.length,r):i.length;;){if((o%=s)<0&&(o+=s),!n||i[a].loci.structure===i[o].loci.structure){var u=i[a];i[a]=i[o],i[o]=u;break}o+="up"===t?-1:1}this.events.additionsHistoryUpdated.next()}},t.prototype.tryAddHistory=function(e){if(!me.Loci.isEmpty(e)){for(var t=0,r=void 0,n=0,i=this.additionsHistory;n<i.length;n++){var a=i[n];if(me.Loci.areEqual(a.loci,e)){r=a;break}t++}if(r)return Object(j.arrayRemoveAtInPlace)(this.additionsHistory,t),this.additionsHistory.unshift(r),void this.events.additionsHistoryUpdated.next();var o=A.StructureElement.Stats.ofLoci(e),s=Object(we.structureElementStatsLabel)(o,{reverse:!0});this.additionsHistory.unshift({id:De.c.create22(),loci:e,label:s}),this.additionsHistory.length>24&&this.additionsHistory.pop(),this.events.additionsHistoryUpdated.next()}},t.prototype.clearHistory=function(){0!==this.state.additionsHistory.length&&(this.state.additionsHistory=[],this.events.additionsHistoryUpdated.next())},t.prototype.clearHistoryForStructure=function(e){for(var t=[],r=0,n=this.state.additionsHistory;r<n.length;r++){(o=n[r]).loci.structure.root===e.root&&t.push(o)}for(var i=0,a=t;i<a.length;i++){var o=a[i];this.modifyHistory(o,"remove")}0!==t.length&&this.events.additionsHistoryUpdated.next()},t.prototype.onRemove=function(e,t){var r;this.entries.has(e)&&(this.entries.delete(e),(null==t?void 0:t.data)&&this.clearHistoryForStructure(t.data),(null===(r=this.referenceLoci)||void 0===r?void 0:r.structure)===(null==t?void 0:t.data)&&(this.referenceLoci=void 0),this.state.stats=void 0,this.events.changed.next())},t.prototype.onUpdate=function(e,t,r){var n,i,a,o;if(t!==r&&(null==t?void 0:t.data)!==r.data){var s=this.plugin.helpers.substructureParent.get(r.data,!0);if(s&&(e=s.transform.ref,this.entries.has(e))){var u=null===(i=null===(n=this.plugin.helpers.substructureParent.get(r.data))||void 0===n?void 0:n.obj)||void 0===i?void 0:i.data;if(u)if(!(null==t?void 0:t.data)||A.Structure.areUnitIdsAndIndicesEqual(t.data,r.data)){this.entries.set(e,function(e,t){return new Me(A.StructureElement.Loci.remap(e.selection,t))}(this.entries.get(e),u)),(null===(a=this.referenceLoci)||void 0===a?void 0:a.structure.root)===u.root&&(this.referenceLoci=A.StructureElement.Loci.remap(this.referenceLoci,u));for(var c=!1,l=0,d=this.state.additionsHistory;l<d.length;l++){var f=d[l];f.loci.structure.root===u.root&&(f.loci=A.StructureElement.Loci.remap(f.loci,u),c=!0)}c&&this.events.additionsHistoryUpdated.next()}else this.entries.set(e,new Me(A.StructureElement.Loci(u,[]))),(null===(o=this.referenceLoci)||void 0===o?void 0:o.structure.root)===u.root&&(this.referenceLoci=void 0),this.clearHistoryForStructure(u),this.state.stats=void 0,this.events.changed.next()}}},t.prototype.clear=function(){for(var e=this.entries.keys(),t=[];;){var r=e.next();if(r.done)break;var n=this.entries.get(r.value);A.StructureElement.Loci.isEmpty(n.selection)||t.push(n.selection),n.selection=A.StructureElement.Loci(n.selection.structure,[])}return this.referenceLoci=void 0,this.state.stats=void 0,this.events.changed.next(),this.events.loci.clear.next(),this.clearHistory(),t},t.prototype.getLoci=function(e){var t=this.getEntry(e);return t?t.selection:me.EmptyLoci},t.prototype.getStructure=function(e){var t=this.getEntry(e);if(t)return t.structure},t.prototype.structureHasSelection=function(e){var t,r,n=null===(r=null===(t=e.cell)||void 0===t?void 0:t.obj)||void 0===r?void 0:r.data;if(!n)return!1;var i=this.getEntry(n);return!!i&&!A.StructureElement.Loci.isEmpty(i.selection)},t.prototype.has=function(e){if(A.StructureElement.Loci.is(e)){var t=this.getEntry(e.structure);if(t)return A.StructureElement.Loci.isSubset(t.selection,e)}return!1},t.prototype.tryGetRange=function(e){if(A.StructureElement.Loci.is(e)&&(1===e.elements.length&&this.getEntry(e.structure))){var t=e.elements[0];if(t){var r=this.referenceLoci;if(r&&A.StructureElement.Loci.is(r)&&r.structure===e.structure){for(var n,i=0,a=r.elements;i<a.length;i++){var o=a[i];if(t.unit===o.unit){n=o;break}}if(n&&t.unit===n.unit)return function(e,t,r){var n=Math.min(Ee.OrderedSet.min(t.indices),Ee.OrderedSet.min(r.indices)),i=Math.max(Ee.OrderedSet.max(t.indices),Ee.OrderedSet.max(r.indices));return A.StructureElement.Loci(e,[{unit:t.unit,indices:Ee.OrderedSet.ofRange(n,i)}])}(e.structure,n,t)}}}},t.prototype.elementCount=function(){var e=0;return this.entries.forEach((function(t){e+=A.StructureElement.Loci.size(t.selection)})),e},t.prototype.getBoundary=function(){var e=M.Vec3.create(Number.MAX_VALUE,Number.MAX_VALUE,Number.MAX_VALUE),t=M.Vec3.create(-Number.MAX_VALUE,-Number.MAX_VALUE,-Number.MAX_VALUE);Te.reset();var r=[];this.entries.forEach((function(e){var t=e.selection;A.StructureElement.Loci.isEmpty(t)||r.push(A.StructureElement.Loci.getBoundary(t))}));for(var n=0,i=r.length;n<i;++n){var a=r[n],o=a.box,s=a.sphere;M.Vec3.min(e,e,o.min),M.Vec3.max(t,t,o.max),Te.includePositionRadius(s.center,s.radius)}Te.finishedIncludeStep();for(n=0,i=r.length;n<i;++n){s=r[n].sphere;Te.radiusPositionRadius(s.center,s.radius)}return{box:{min:e,max:t},sphere:Te.getSphere()}},t.prototype.getPrincipalAxes=function(){var e=this.elementCount(),t=new Float32Array(3*e),r=0;return this.entries.forEach((function(e){A.StructureElement.Loci.toPositionsArray(e.selection,t,r),r+=3*A.StructureElement.Loci.size(e.selection)})),Ae.a.ofPositions(t)},t.prototype.modify=function(e,t){var r=!1;switch(e){case"add":r=this.add(t);break;case"remove":r=this.remove(t);break;case"intersect":r=this.intersect(t);break;case"set":r=this.set(t)}r&&(this.state.stats=void 0,this.events.changed.next())},Object.defineProperty(t.prototype,"applicableStructures",{get:function(){return this.plugin.managers.structure.hierarchy.selection.structures.filter((function(e){return!!e.cell.obj})).map((function(e){return e.cell.obj.data}))},enumerable:!1,configurable:!0}),t.prototype.triggerInteraction=function(e,t,r){switch(void 0===r&&(r=!0),e){case"add":this.plugin.managers.interactivity.lociSelects.select({loci:t},r);break;case"remove":this.plugin.managers.interactivity.lociSelects.deselect({loci:t},r);break;case"intersect":this.plugin.managers.interactivity.lociSelects.selectJoin({loci:t},r);break;case"set":this.plugin.managers.interactivity.lociSelects.selectOnly({loci:t},r)}},t.prototype.fromLoci=function(e,t,r){void 0===r&&(r=!0),this.triggerInteraction(e,t,r)},t.prototype.fromSelectionQuery=function(e,t,r){var n=this;void 0===r&&(r=!0),this.plugin.runTask(_.b.create("Structure Selection",(function(i){return Object(o.__awaiter)(n,void 0,void 0,(function(){var n,a,s,u;return Object(o.__generator)(this,(function(o){switch(o.label){case 0:n=0,a=this.applicableStructures,o.label=1;case 1:return n<a.length?(s=a[n],[4,t.getSelection(this.plugin,i,s)]):[3,4];case 2:u=o.sent(),this.triggerInteraction(e,A.StructureSelection.toLociWithSourceUnits(u),r),o.label=3;case 3:return n++,[3,1];case 4:return[2]}}))}))})))},t.prototype.fromSelections=function(e){var t,r=g.StateObjectRef.resolveAndCheck(this.plugin.state.data,e);if(r&&r.obj)if(v.a.Molecule.Structure.Selections.is(r.obj)){this.clear();for(var n=0,i=null===(t=r.obj)||void 0===t?void 0:t.data;n<i.length;n++){var a=i[n];this.fromLoci("set",a.loci)}}else console.warn("fromSelections applied to wrong object type.",r.obj)},t}(Oe.b);var Me=function(){function e(e){this._structure=void 0,this._selection=e}return Object.defineProperty(e.prototype,"selection",{get:function(){return this._selection},set:function(e){this._selection=e,this._structure=void 0},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"structure",{get:function(){return this._structure||(me.Loci.isEmpty(this._selection)?this._structure=void 0:this._structure=A.StructureElement.Loci.toStructure(this._selection)),this._structure},enumerable:!1,configurable:!0}),e}();var ke,Be,Ve=r(38),Re=r(112),Le=r(49),Ne=r(22),Fe=r(53),Ue=r(291),ze=r(50),He={includeTypes:d.ParamDefinition.MultiSelect(Object(Ue.a)(Ne.BondType.Names),d.ParamDefinition.objectToOptions(Ne.BondType.Names)),excludeTypes:d.ParamDefinition.MultiSelect([],d.ParamDefinition.objectToOptions(Ne.BondType.Names)),ignoreHydrogens:d.ParamDefinition.Boolean(!1)},Ge=(d.ParamDefinition.getDefaultValues(He),Object(o.__assign)(Object(o.__assign)({},Re.a),He)),qe=(d.ParamDefinition.getDefaultValues(Ge),Object(o.__assign)(Object(o.__assign)({},Re.b),He));d.ParamDefinition.getDefaultValues(qe);function We(e,t,r){return!Ne.BondType.is(e,r)||Ne.BondType.is(t,r)}function Xe(e,t){var r=e.elements,n=e.model.atomicHierarchy.derived.atom.atomicNumber,i=e.bonds,a=i.a,o=i.b,s=i.edgeProps.flags,u=t.ignoreHydrogens,c=t.includeTypes,l=t.excludeTypes,d=Ne.BondType.fromNames(c),f=Ne.BondType.fromNames(l),p=Ne.BondType.isAll(d)&&0===f;return!p&&u?function(e){return Object(ze.n)(n,r[a[e]])||Object(ze.n)(n,r[o[e]])||We(d,f,s[e])}:p?u?function(e){return Object(ze.n)(n,r[a[e]])||Object(ze.n)(n,r[o[e]])}:void 0:function(e){return We(d,f,s[e])}}function Ye(e,t){var r=e.interUnitBonds.edges,n=t.ignoreHydrogens,i=t.includeTypes,a=t.excludeTypes,o=Ne.BondType.fromNames(i),s=Ne.BondType.fromNames(a),u=Ne.BondType.isAll(o)&&0===s,c=function(t){var n=r[t],i=e.unitMap.get(n.unitA),a=e.unitMap.get(n.unitB);return Object(ze.o)(i,i.elements[n.indexA])||Object(ze.o)(a,a.elements[n.indexB])};return!u&&n?function(e){return c(e)||We(o,s,r[e].props.flag)}:u?n?function(e){return c(e)}:void 0:function(e){return We(o,s,r[e].props.flag)}}function Qe(e,t,r){var n=e.objectId,i=e.instanceId,a=e.groupId;if(r===n){var o=t.structure,s=t.group.units[i];if(A.Unit.isAtomic(s))return A.Bond.Loci(o,[A.Bond.Location(o,s,s.bonds.a[a],o,s,s.bonds.b[a]),A.Bond.Location(o,s,s.bonds.b[a],o,s,s.bonds.a[a])])}return me.EmptyLoci}function Ke(e,t,r,n){var i=!1;if(A.Bond.isLoci(e)){var a=t.structure,o=t.group;if(!A.Structure.areEquivalent(e.structure,a))return!1;var s=o.units[0];if(!A.Unit.isAtomic(s))return!1;for(var u=2*s.bonds.edgeCount,c=0,l=e.bonds;c<l.length;c++){var d=l[c];if(d.aUnit===d.bUnit){var f=o.unitIndexMap.get(d.aUnit.id);if(void 0!==f){var p=s.bonds.getDirectedEdgeIndex(d.aIndex,d.bIndex);-1!==p&&r(Ee.Interval.ofSingleton(f*u+p))&&(i=!0)}}}}else if(A.StructureElement.Loci.is(e)){a=t.structure,o=t.group;if(!A.Structure.areEquivalent(e.structure,a))return!1;s=o.units[0];if(!A.Unit.isAtomic(s))return!1;for(var m=2*s.bonds.edgeCount,h=function(e){var t=o.unitIndexMap.get(e.unit.id);if(void 0!==t){var a=s.bonds,u=a.offset,c=a.b;Ee.OrderedSet.forEach(e.indices,(function(a){for(var o=u[a],s=u[a+1];o<s;o++)n&&!Ee.OrderedSet.has(e.indices,c[o])||r(Ee.Interval.ofSingleton(t*m+o))&&(i=!0)}))}},g=0,v=e.elements;g<v.length;g++){h(v[g])}}return i}function Ze(e,t,r){var n=e.objectId,i=e.groupId;if(r===n){var a=t.interUnitBonds.edges[i],o=t.unitMap.get(a.unitA),s=t.unitMap.get(a.unitB);return A.Bond.Loci(t,[A.Bond.Location(t,o,a.indexA,t,s,a.indexB),A.Bond.Location(t,s,a.indexB,t,o,a.indexA)])}return me.EmptyLoci}function Je(e,t,r,n){var i=!1;if(A.Bond.isLoci(e)){if(!A.Structure.areEquivalent(e.structure,t))return!1;for(var a=0,o=e.bonds;a<o.length;a++){var s=o[a],u=t.interUnitBonds.getBondIndexFromLocation(s);-1!==u&&r(Ee.Interval.ofSingleton(u))&&(i=!0)}}else if(A.StructureElement.Loci.is(e)){if(!A.Structure.areEquivalent(e.structure,t))return!1;if(n&&1===e.elements.length)return!1;for(var c=new Map,l=0,d=e.elements;l<d.length;l++){var f=d[l];c.set(f.unit.id,f.indices)}for(var p=function(e){var a=e.unit;if(!A.Unit.isAtomic(a))return"continue";t.interUnitBonds.getConnectedUnits(a.id).forEach((function(o){var s=c.get(o.unitB);n&&!s||Ee.OrderedSet.forEach(e.indices,(function(e){o.connectedIndices.includes(e)&&o.getEdges(e).forEach((function(u){if(!n||s&&Ee.OrderedSet.has(s,u.indexB)){var c=t.interUnitBonds.getEdgeIndex(e,a.id,u.indexB,o.unitB);r(Ee.Interval.ofSingleton(c))&&(i=!0)}}))}))}))},m=0,h=e.elements;m<h.length;m++){p(f=h[m])}}return i}(Be=ke||(ke={})).fromGroup=function(e){var t=e.group,r=e.structure,n=t.units[0],i=A.Unit.isAtomic(n)?2*n.bonds.edgeCount:0,a=t.units.length,o=A.Bond.Location();return o.aStructure=r,o.bStructure=r,Object(Fe.a)(i,a,1,(function(e,r){var n=t.units[r];return o.aUnit=n,o.bUnit=n,o.aIndex=n.bonds.a[e],o.bIndex=n.bonds.b[e],o}))},Be.fromStructure=function(e){var t=e.interUnitBonds.edgeCount,r=A.Bond.Location();return r.aStructure=e,r.bStructure=e,Object(Fe.a)(t,1,1,(function(t){var n=e.interUnitBonds.edges[t];return r.aUnit=e.unitMap.get(n.unitA),r.aIndex=n.indexA,r.bUnit=e.unitMap.get(n.unitB),r.bIndex=n.indexB,r}),!0)};var $e=r(145),et=r(166),tt=Ne.BondType.is;function rt(e,t,r,n){var i=A.StructureElement.Location.create(t,e),a=A.Bond.Location(t,e,void 0,t,e,void 0),o=e.elements,s=e.bonds,u=s.edgeCount,c=s.a,l=s.b,d=s.edgeProps,f=s.offset,p=d.order,m=d.flags,h=n.sizeFactor,g=n.sizeAspectRatio,v=Object(M.Vec3)(),b=Object(M.Vec3)(),y=e.conformation.invariantPosition;return{linkCount:2*u,referencePosition:function(e){var t,r,n=c[e],i=l[e];n>i&&(n=(t=[i,n])[0],i=t[1]),f[n+1]-f[n]==1&&(n=(r=[i,n])[0],i=r[1]);for(var a=f[n],s=f[n+1];a<s;++a){var u=l[a];if(u!==i&&u!==n)return y(o[u],v)}for(a=f[i],s=f[i+1];a<s;++a){var d=c[a];if(d!==n&&d!==i)return y(o[d],v)}return null},position:function(e,t,n){var a=function(e){return i.element=o[c[e]],r.size.size(i)*h}(n),s=function(e){return i.element=o[l[e]],r.size.size(i)*h}(n),u=Math.min(a,s)*g,d=Math.sqrt(Math.max(0,a*a-u*u))-.05,f=Math.sqrt(Math.max(0,s*s-u*u))-.05;y(o[c[n]],e),y(o[l[n]],t),d<=.01&&f<=.01||(M.Vec3.normalize(b,M.Vec3.sub(b,t,e)),M.Vec3.scaleAndAdd(e,e,b,d),M.Vec3.scaleAndAdd(t,t,b,-f))},style:function(e){var t=p[e],r=m[e];return tt(r,2)||tt(r,4)?1:2===t?2:3===t?3:0},radius:function(e){return function(e){return a.aIndex=c[e],a.bIndex=l[e],r.size.size(a)*h}(e)*g},ignore:Xe(e,n)}}function nt(e,t,r,n,i,a){if(!A.Unit.isAtomic(t))return et.a.createEmpty(a);if(!t.bonds.edgeCount)return et.a.createEmpty(a);var o=rt(t,r,n,i),s=Object(Re.c)(e,o,i,a),u=T.g.expand(Object(T.g)(),t.boundary.sphere,1*i.sizeFactor);return s.setBoundingSphere(u),s}function it(e,t,r,n,i,a){if(!A.Unit.isAtomic(t))return Ve.a.createEmpty(a);if(!t.bonds.edgeCount)return Ve.a.createEmpty(a);var o=rt(t,r,n,i),s=Object(Re.d)(e,o,i,a),u=T.g.expand(Object(T.g)(),t.boundary.sphere,1*i.sizeFactor);return s.setBoundingSphere(u),s}var at=Object(o.__assign)(Object(o.__assign)(Object(o.__assign)(Object(o.__assign)({},Le.g),Le.a),Ge),{sizeFactor:d.ParamDefinition.Numeric(.3,{min:0,max:10,step:.01}),sizeAspectRatio:d.ParamDefinition.Numeric(2/3,{min:0,max:3,step:.01}),tryUseImpostor:d.ParamDefinition.Boolean(!0)});function ot(e,t,r,n){return r.tryUseImpostor&&n&&n.extensions.fragDepth?function(e){return Object(Le.b)({defaultProps:d.ParamDefinition.getDefaultValues(at),createGeometry:nt,createLocationIterator:ke.fromGroup,getLoci:Qe,eachLocation:Ke,setUpdateState:function(e,t,r,n,i,a,o){e.createGeometry=t.linkScale!==r.linkScale||t.linkSpacing!==r.linkSpacing||t.ignoreHydrogens!==r.ignoreHydrogens||t.linkCap!==r.linkCap||t.dashCount!==r.dashCount||t.dashScale!==r.dashScale||t.dashCap!==r.dashCap||!Object(De.f)(t.includeTypes,r.includeTypes)||!Object(De.f)(t.excludeTypes,r.excludeTypes);var s=a.group.units[0],u=o.group.units[0];A.Unit.isAtomic(s)&&A.Unit.isAtomic(u)&&($e.a.areEqual(s.bonds,u.bonds)||(e.createGeometry=!0,e.updateTransform=!0,e.updateColor=!0,e.updateSize=!0))},mustRecreate:function(e,t,r){return!t.tryUseImpostor||!r}},e)}(e):function(e){return Object(Le.h)({defaultProps:d.ParamDefinition.getDefaultValues(at),createGeometry:it,createLocationIterator:ke.fromGroup,getLoci:Qe,eachLocation:Ke,setUpdateState:function(e,t,r,n,i,a,o){e.createGeometry=t.sizeFactor!==r.sizeFactor||t.sizeAspectRatio!==r.sizeAspectRatio||t.radialSegments!==r.radialSegments||t.linkScale!==r.linkScale||t.linkSpacing!==r.linkSpacing||t.ignoreHydrogens!==r.ignoreHydrogens||t.linkCap!==r.linkCap||t.dashCount!==r.dashCount||t.dashScale!==r.dashScale||t.dashCap!==r.dashCap||!Object(De.f)(t.includeTypes,r.includeTypes)||!Object(De.f)(t.excludeTypes,r.excludeTypes);var s=a.group.units[0],u=o.group.units[0];A.Unit.isAtomic(s)&&A.Unit.isAtomic(u)&&($e.a.areEqual(s.bonds,u.bonds)||(e.createGeometry=!0,e.updateTransform=!0,e.updateColor=!0,e.updateSize=!0))},mustRecreate:function(e,t,r){return t.tryUseImpostor&&!!r}},e)}(e)}var st=r(92),ut=new A.Bond.ElementBondIterator;function ct(e,t,r,n){for(ut.setElement(t,r,n);ut.hasNext;){var i=ut.move();return i.otherUnit.conformation.position(i.otherUnit.elements[i.otherIndex],e),e}return null}var lt=Object(M.Vec3)();function dt(e,t,r){var n=A.StructureElement.Location.create(e),i=A.Bond.Location(e,void 0,void 0,e,void 0,void 0),a=e.interUnitBonds,o=a.edgeCount,s=a.edges,u=r.sizeFactor,c=r.sizeAspectRatio,l=Object(M.Vec3)();return{linkCount:o,referencePosition:function(t){var r,n,i,a,o=s[t];if(o.unitA<o.unitB)r=e.unitMap.get(o.unitA),n=e.unitMap.get(o.unitB),i=o.indexA,a=o.indexB;else{if(!(o.unitA>o.unitB))throw new Error("same units in createInterUnitBondCylinderMesh");r=e.unitMap.get(o.unitB),n=e.unitMap.get(o.unitA),i=o.indexB,a=o.indexA}return ct(lt,e,r,i)||ct(lt,e,n,a)},position:function(r,i,a){var o=s[a],d=e.unitMap.get(o.unitA),f=e.unitMap.get(o.unitB),p=function(r){var i=s[r];return n.unit=e.unitMap.get(i.unitA),n.element=n.unit.elements[i.indexA],t.size.size(n)*u}(a),m=function(r){var i=s[r];return n.unit=e.unitMap.get(i.unitB),n.element=n.unit.elements[i.indexB],t.size.size(n)*u}(a),h=Math.min(p,m)*c,g=Math.sqrt(Math.max(0,p*p-h*h))-.05,v=Math.sqrt(Math.max(0,m*m-h*h))-.05;d.conformation.position(d.elements[o.indexA],r),f.conformation.position(f.elements[o.indexB],i),g<=.01&&v<=.01||(M.Vec3.normalize(l,M.Vec3.sub(l,i,r)),M.Vec3.scaleAndAdd(r,r,l,g),M.Vec3.scaleAndAdd(i,i,l,-v))},style:function(e){var t=s[e].props.order,r=De.a.create(s[e].props.flag);return Ne.BondType.is(r,2)||Ne.BondType.is(r,4)?1:2===t?2:3===t?3:0},radius:function(r){return function(r){var n=s[r];return i.aUnit=e.unitMap.get(n.unitA),i.aIndex=n.indexA,i.bUnit=e.unitMap.get(n.unitB),i.bIndex=n.indexB,t.size.size(i)*u}(r)*c},ignore:Ye(e,r)}}function ft(e,t,r,n,i){if(!t.interUnitBonds.edgeCount)return et.a.createEmpty(i);var a=dt(t,r,n),o=Object(Re.c)(e,a,n,i),s=T.g.expand(Object(T.g)(),t.boundary.sphere,1*n.sizeFactor);return o.setBoundingSphere(s),o}function pt(e,t,r,n,i){if(!t.interUnitBonds.edgeCount)return Ve.a.createEmpty(i);var a=dt(t,r,n),o=Object(Re.d)(e,a,n,i),s=T.g.expand(Object(T.g)(),t.boundary.sphere,1*n.sizeFactor);return o.setBoundingSphere(s),o}var mt=Object(o.__assign)(Object(o.__assign)(Object(o.__assign)(Object(o.__assign)({},st.g),st.a),Ge),{sizeFactor:d.ParamDefinition.Numeric(.3,{min:0,max:10,step:.01}),sizeAspectRatio:d.ParamDefinition.Numeric(2/3,{min:0,max:3,step:.01}),tryUseImpostor:d.ParamDefinition.Boolean(!0)});function ht(e,t,r,n){return r.tryUseImpostor&&n&&n.extensions.fragDepth?function(e){return Object(st.b)({defaultProps:d.ParamDefinition.getDefaultValues(mt),createGeometry:ft,createLocationIterator:ke.fromStructure,getLoci:Ze,eachLocation:Je,setUpdateState:function(e,t,r){e.createGeometry=t.linkScale!==r.linkScale||t.linkSpacing!==r.linkSpacing||t.ignoreHydrogens!==r.ignoreHydrogens||t.linkCap!==r.linkCap||t.dashCount!==r.dashCount||t.dashScale!==r.dashScale||t.dashCap!==r.dashCap||!Object(De.f)(t.includeTypes,r.includeTypes)||!Object(De.f)(t.excludeTypes,r.excludeTypes)},mustRecreate:function(e,t,r){return!t.tryUseImpostor||!r}},e)}(e):function(e){return Object(st.h)({defaultProps:d.ParamDefinition.getDefaultValues(mt),createGeometry:pt,createLocationIterator:ke.fromStructure,getLoci:Ze,eachLocation:Je,setUpdateState:function(e,t,r){e.createGeometry=t.sizeFactor!==r.sizeFactor||t.sizeAspectRatio!==r.sizeAspectRatio||t.radialSegments!==r.radialSegments||t.linkScale!==r.linkScale||t.linkSpacing!==r.linkSpacing||t.ignoreHydrogens!==r.ignoreHydrogens||t.linkCap!==r.linkCap||t.dashCount!==r.dashCount||t.dashScale!==r.dashScale||t.dashCap!==r.dashCap||!Object(De.f)(t.includeTypes,r.includeTypes)||!Object(De.f)(t.excludeTypes,r.excludeTypes)},mustRecreate:function(e,t,r){return t.tryUseImpostor&&!!r}},e)}(e)}var gt,vt,bt,yt=r(272),_t=r(35),St=r(82),xt=r(270),Ot=new Float32Array([-1,1,-1,-1,1,1,1,-1]),wt=new Uint16Array([0,1,2,1,3,2]),Ct=y.a.add3,jt=y.a.add2,Pt=y.a.add;function Et(e,t){var r=t.ignoreHydrogens,n=t.traceOnly,i=e.model.atomicHierarchy.derived.atom.atomicNumber,a=A.Unit.isCoarse(e);return!a&&r&&n?function(e,t){return Object(ze.n)(i,t)&&!Object(ze.p)(e,t)}:!a&&r?function(e,t){return Object(ze.n)(i,t)}:!a&&n?function(e,t){return!Object(ze.p)(e,t)}:void 0}function At(e,t,r,n,i,a){var o=i.detail,s=i.sizeFactor,u=t.elements,c=u.length,l=c*Object(yt.b)(o),d=_t.a.createState(l,l/2,a),f=Object(M.Vec3)(),p=t.conformation.invariantPosition,m=Et(t,i),h=A.StructureElement.Location.create(r);h.unit=t;for(var g=0,v=0;v<c;v++)if(!m||!m(t,u[v])){h.element=u[v],p(u[v],f),d.currentGroup=v;var b=n.size.size(h);b>g&&(g=b),Object(St.a)(d,f,b*s,o)}var y=_t.a.getMesh(d),_=T.g.expand(Object(T.g)(),t.boundary.sphere,g*s+.05);return y.setBoundingSphere(_),y}function Dt(e,t,r,n,i,a){for(var o=t.elements,s=o.length,u=gt.create(s,s/2,a),c=Object(M.Vec3)(),l=t.conformation.invariantPosition,d=Et(t,i),f=A.StructureElement.Location.create(r,t),p=0,m=0;m<s;m++)if(!(null==d?void 0:d(t,o[m]))){l(o[m],c),u.add(c[0],c[1],c[2],m),f.element=o[m];var h=n.size.size(f);h>p&&(p=h)}var g=u.getSpheres();return g.setBoundingSphere(T.g.expand(Object(T.g)(),t.boundary.sphere,p*i.sizeFactor+.05)),g}function Tt(e,t,r){var n=!1;if(!A.StructureElement.Loci.is(e))return!1;var i=t.structure,a=t.group;if(!A.Structure.areEquivalent(e.structure,i))return!1;for(var o=a.elements.length,s=0,u=e.elements;s<u.length;s++){var c=u[s],l=a.unitIndexMap.get(c.unit.id);if(void 0!==l){var d=l*o;if(Ee.Interval.is(c.indices)){var f=d+Ee.Interval.start(c.indices),p=d+Ee.Interval.end(c.indices);r(Ee.Interval.ofBounds(f,p))&&(n=!0)}else for(var m=0,h=c.indices.length;m<h;m++){f=c.indices[m];for(var g=m+1;g<h&&c.indices[g]===f;)g++;m=g-1;p=c.indices[m];n=r(Ee.Interval.ofRange(d+f,d+p))||n}}}return n}function It(e,t,r){var n=e.objectId,i=e.instanceId,a=e.groupId;if(r===n){var o=t.structure,s=t.group.units[i],u=Ee.OrderedSet.ofSingleton(a);return A.StructureElement.Loci(o,[{unit:s,indices:u}])}return me.EmptyLoci}function Mt(e,t,r){var n=!1;if(!A.StructureElement.Loci.is(e))return!1;if(!A.Structure.areEquivalent(e.structure,t))return!1;for(var i=t.serialMapping.cumulativeUnitElementCount,a=0,o=e.elements;a<o.length;a++){var s=o[a],u=t.unitIndexMap.get(s.unit.id);if(void 0!==u)if(Ee.Interval.is(s.indices)){var c=i[u]+Ee.Interval.start(s.indices),l=i[u]+Ee.Interval.end(s.indices);r(Ee.Interval.ofBounds(c,l))&&(n=!0)}else for(var d=0,f=s.indices.length;d<f;d++){var p=i[u]+s.indices[d];r(Ee.Interval.ofSingleton(p))&&(n=!0)}}return n}function kt(e,t,r){var n=e.objectId,i=e.groupId;if(r===n){var a=t.serialMapping,o=a.unitIndices,s=a.cumulativeUnitElementCount,u=o[i],c=t.units[u],l=i-s[u],d=Ee.OrderedSet.ofSingleton(l);return A.StructureElement.Loci(t,[{unit:c,indices:d}])}return me.EmptyLoci}(gt||(gt={})).create=function(e,t,r){void 0===e&&(e=2048),void 0===t&&(t=1024),e*=4,t*=4;var n=y.a.create(Float32Array,3,t,r?r.centerBuffer.ref.value:e),i=y.a.create(Float32Array,2,t,r?r.mappingBuffer.ref.value:e),a=y.a.create(Uint32Array,3,t/2,r?r.indexBuffer.ref.value:e/2),o=y.a.create(Float32Array,1,t,r?r.groupBuffer.ref.value:e);return{add:function(e,t,r,s){for(var u=n.elementCount,c=0;c<4;++c)Ct(n,e,t,r),jt(i,Ot[2*c],Ot[2*c+1]),Pt(o,s);Ct(a,u+wt[0],u+wt[1],u+wt[2]),Ct(a,u+wt[3],u+wt[4],u+wt[5])},getSpheres:function(){var e=y.a.compact(n,!0),t=y.a.compact(i,!0),s=y.a.compact(a,!0),u=y.a.compact(o,!0);return xt.a.create(e,t,s,u,n.elementCount/4,r)}}},(bt=vt||(vt={})).fromGroup=function(e){var t=e.group,r=e.structure,n=t.elements.length,i=t.units.length,a=A.StructureElement.Location.create(r);return Object(Fe.a)(n,i,1,(function(e,r){var n=t.units[r];return a.unit=n,a.element=n.elements[e],a}))},bt.fromStructure=function(e){var t=e.units,r=e.elementCount,n=e.serialMapping,i=n.unitIndices,a=n.elementIndices,o=A.StructureElement.Location.create(e);return Object(Fe.a)(r,1,1,(function(e){return o.unit=t[i[e]],o.element=a[e],o}),!0)};var Bt=r(30),Vt=Object(o.__assign)(Object(o.__assign)(Object(o.__assign)({},Le.g),Le.k),{sizeFactor:d.ParamDefinition.Numeric(1,{min:0,max:10,step:.1}),detail:d.ParamDefinition.Numeric(0,{min:0,max:3,step:1},Bt.a.CustomQualityParamInfo),ignoreHydrogens:d.ParamDefinition.Boolean(!1),traceOnly:d.ParamDefinition.Boolean(!1),tryUseImpostor:d.ParamDefinition.Boolean(!0)});function Rt(e,t,r,n){return r.tryUseImpostor&&n&&n.extensions.fragDepth?function(e){return Object(Le.l)({defaultProps:d.ParamDefinition.getDefaultValues(Vt),createGeometry:Dt,createLocationIterator:vt.fromGroup,getLoci:It,eachLocation:Tt,setUpdateState:function(e,t,r){e.createGeometry=t.ignoreHydrogens!==r.ignoreHydrogens||t.traceOnly!==r.traceOnly},mustRecreate:function(e,t,r){return!t.tryUseImpostor||!r}},e)}(e):function(e){return Object(Le.h)({defaultProps:d.ParamDefinition.getDefaultValues(Vt),createGeometry:At,createLocationIterator:vt.fromGroup,getLoci:It,eachLocation:Tt,setUpdateState:function(e,t,r){e.createGeometry=t.sizeFactor!==r.sizeFactor||t.detail!==r.detail||t.ignoreHydrogens!==r.ignoreHydrogens||t.traceOnly!==r.traceOnly},mustRecreate:function(e,t,r){return t.tryUseImpostor&&!!r}},e)}(e)}var Lt=r(110),Nt=r(233),Ft=r(55),Ut=r(86),zt={"element-sphere":function(e,t){return Object(Lt.a)("Element sphere",e,t,Rt)},"intra-bond":function(e,t){return Object(Lt.a)("Intra-unit bond cylinder",e,t,ot)},"inter-bond":function(e,t){return Object(Nt.a)("Inter-unit bond cylinder",e,t,ht)}},Ht=Object(o.__assign)(Object(o.__assign)(Object(o.__assign)(Object(o.__assign)({},Vt),at),mt),{unitKinds:Object(Ut.j)(["atomic"]),sizeFactor:d.ParamDefinition.Numeric(.15,{min:.01,max:10,step:.01}),sizeAspectRatio:d.ParamDefinition.Numeric(2/3,{min:.01,max:3,step:.01}),visuals:d.ParamDefinition.MultiSelect(["element-sphere","intra-bond","inter-bond"],d.ParamDefinition.objectToOptions(zt))});var Gt=Object(Ft.b)({name:"ball-and-stick",label:"Ball & Stick",description:"Displays atoms as spheres and bonds as cylinders.",factory:function(e,t){return ye.a.createMulti("Ball & Stick",e,t,Ft.c,zt)},getParams:function(e,t){return d.ParamDefinition.clone(Ht)},defaultValues:d.ParamDefinition.getDefaultValues(Ht),defaultColorTheme:{name:"element-symbol"},defaultSizeTheme:{name:"physical"},isApplicable:function(e){return e.elementCount>0}});function qt(e,t,r,n,i){var a=t.carbohydrates,o=a.links,s=a.elements,u=n.linkSizeFactor,c=A.StructureElement.Location.create(t),l={linkCount:o.length,position:function(e,t,r){var n=o[r];M.Vec3.copy(e,s[n.carbohydrateIndexA].geometry.center),M.Vec3.copy(t,s[n.carbohydrateIndexB].geometry.center)},radius:function(e){var t=o[e],n=s[t.carbohydrateIndexA],i=n.unit.rings.all[n.ringIndex];return c.unit=n.unit,c.element=n.unit.elements[i[0]],r.size.size(c)*u}};return Object(Re.d)(e,l,n,i)}var Wt=Object(o.__assign)(Object(o.__assign)(Object(o.__assign)({},Le.g),Re.a),{linkSizeFactor:d.ParamDefinition.Numeric(.3,{min:0,max:3,step:.01})});function Xt(e){return Object(st.h)({defaultProps:d.ParamDefinition.getDefaultValues(Wt),createGeometry:qt,createLocationIterator:Yt,getLoci:Qt,eachLocation:Kt,setUpdateState:function(e,t,r){e.createGeometry=t.linkSizeFactor!==r.linkSizeFactor||t.radialSegments!==r.radialSegments||t.linkCap!==r.linkCap}},e)}function Yt(e){var t=e.carbohydrates,r=t.elements,n=t.links,i=n.length,a=A.StructureElement.Location.create(e);return Object(Fe.a)(i,1,1,(function(e){var t=n[e],i=r[t.carbohydrateIndexA],o=i.unit.rings.all[i.ringIndex];return a.unit=i.unit,a.element=i.unit.elements[o[0]],a}),!0)}function Qt(e,t,r){var n=e.objectId,i=e.groupId;if(r===n){var a=t.carbohydrates,o=a.links,s=a.elements,u=o[i],c=s[u.carbohydrateIndexA],l=s[u.carbohydrateIndexB];return A.StructureElement.Loci.union(Object(ze.f)(t,c.unit,c.residueIndex,c.altId),Object(ze.f)(t,l.unit,l.residueIndex,l.altId))}return me.EmptyLoci}function Kt(e,t,r){var n=!1;if(!A.StructureElement.Loci.is(e))return!1;if(!A.Structure.areEquivalent(e.structure,t))return!1;for(var i=t.carbohydrates.getLinkIndices,a=function(e,t){if(!A.Unit.isAtomic(e))return"continue";Ee.OrderedSet.forEach(t,(function(t){for(var a=i(e,e.elements[t]),o=0,s=a.length;o<s;++o)r(Ee.Interval.ofSingleton(a[o]))&&(n=!0)}))},o=0,s=e.elements;o<s.length;o++){var u=s[o];a(u.unit,u.indices)}return n}var Zt,Jt,$t=r(256),er=r(137),tr=r(153),rr=M.Vec3.create(0,0,-.5),nr=M.Vec3.create(0,0,.5),ir=Object(M.Vec3)(),ar=Object(M.Vec3)(),or=Object(M.Vec3)(),sr=Object(M.Vec3)();function ur(e){for(var t=e.length/3,r=(3===t?1:4===t?2:t)+t,n=4===t?3*t+4:3*r,i=Object(er.a)(r,n),a=0;a<t;++a){var o=(a+1)%t;M.Vec3.set(ir,e[3*a],e[3*a+1],-.5),M.Vec3.set(ar,e[3*o],e[3*o+1],-.5),i.add(ir,ar,nr)}if(3===t)M.Vec3.set(ir,e[0],e[1],-.5),M.Vec3.set(ar,e[3],e[4],-.5),M.Vec3.set(or,e[6],e[7],-.5),i.add(or,ar,ir);else if(4===t)M.Vec3.set(ir,e[0],e[1],-.5),M.Vec3.set(ar,e[3],e[4],-.5),M.Vec3.set(or,e[6],e[7],-.5),M.Vec3.set(sr,e[9],e[10],-.5),i.addQuad(sr,or,ar,ir);else for(a=0;a<t;++a){o=(a+1)%t;M.Vec3.set(ir,e[3*a],e[3*a+1],-.5),M.Vec3.set(ar,e[3*o],e[3*o+1],-.5),i.add(rr,ar,ir)}return i.getPrimitive()}var cr={pointCount:5,outerRadius:1,innerRadius:.5,thickness:.3},lr=M.Vec3.zero(),dr=M.Vec3.zero(),fr=M.Vec3.zero(),pr=M.Vec3.zero(),mr=M.Vec3.zero();var hr,gr,vr=r(190),br=[.5,0,0,-.5,0,0,0,.5,0,0,-.5,0,0,0,.5,0,0,-.5],yr=[0,2,4,0,4,3,0,3,5,0,5,2,1,2,5,1,5,3,1,3,4,1,4,2],_r=[0,2,4,0,4,3,1,2,5,1,5,3];Object(vr.b)(br,[0,2,1,3,2,1,3,0,0,4,1,4,2,4,3,4,0,5,1,5,2,5,3,5]);var Sr=r(246),xr=r(184),Or=M.Mat4.identity(),wr=M.Vec3.zero(),Cr=M.Vec3.zero(),jr=Object($t.a)(),Pr=Object($t.c)(),Er=(Zt||(Zt=ur(Object(tr.a)(8,!0))),Zt),Ar=function(){if(!Jt){for(var e=Object(tr.a)(8,!0),t=new Float32Array(30),r=0;r<8;++r)t[3*r]=e[3*r],t[3*r+1]=e[3*r+1],t[3*r+2]=-.5;t[24]=0,t[25]=0,t[26]=-.5,t[27]=0,t[28]=0,t[29]=.5;Jt=Object(er.b)(t,[0,1,8,1,2,8,4,5,8,5,6,8,2,3,9,3,4,9,6,7,9,7,0,9])}return Jt}(),Dr=function(e){for(var t=Object(o.__assign)(Object(o.__assign)({},cr),e),r=t.outerRadius,n=t.innerRadius,i=t.thickness,a=t.pointCount,s=2*a*2,u=Object(er.a)(s),c=new Float32Array(2*a),l=new Float32Array(2*a),d=0;d<a;++d){var f=2*d,p=2*d+1,m=(f+1)/a*Math.PI,h=(p+1)/a*Math.PI;l[f]=Math.cos(m)*r,l[p]=Math.sin(m)*r,c[f]=Math.cos(h)*n,c[p]=Math.sin(h)*n}for(M.Vec3.set(lr,0,0,i/2),M.Vec3.set(dr,0,0,-i/2),d=0;d<a;++d){var g=(d+1)%a;M.Vec3.set(fr,l[2*d],l[2*d+1],0),M.Vec3.set(pr,c[2*d],c[2*d+1],0),M.Vec3.set(mr,l[2*g],l[2*g+1],0),u.add(lr,fr,pr),u.add(pr,fr,dr),u.add(lr,pr,mr),u.add(mr,pr,dr)}return u.getPrimitive()}({outerRadius:1,innerRadius:.5,thickness:.5,pointCount:5}),Tr=(hr||(hr=Object(er.b)(br,yr)),hr),Ir=(gr||(gr=Object(er.b)(br,_r)),gr),Mr=Object(Sr.a)(),kr=Object(Sr.d)(),Br=Object(Sr.c)(),Vr=Object(Sr.g)(),Rr=Object(Sr.b)();function Lr(e,t,r,n,i){for(var a=_t.a.createState(256,128,i),o=n.detail,s=n.sizeFactor,u=t.carbohydrates,c=u.elements.length,l=A.StructureElement.Location.create(t),d=0;d<c;++d){var f=u.elements[d],p=f.unit.rings.all[f.ringIndex],m=Object(xr.f)(f.component.type,p.length);l.unit=f.unit,l.element=f.unit.elements[p[0]];var h=r.size.size(l),g=h*s,v=h*s*1.612,b=f.geometry,y=b.center,_=b.normal,S=b.direction;switch(M.Vec3.add(Cr,y,S),M.Mat4.targetTo(Or,y,Cr,_),M.Mat4.setTranslation(Or,y),a.currentGroup=2*d,m){case 0:Object(St.a)(a,y,g,o);break;case 1:M.Mat4.scaleUniformly(Or,Or,v),_t.a.addPrimitive(a,Or,jr);break;case 2:M.Mat4.scaleUniformly(Or,Or,v),_t.a.addPrimitive(a,Or,Pr),M.Mat4.mul(Or,Or,M.Mat4.rotZ90X180),a.currentGroup+=1,_t.a.addPrimitive(a,Or,Pr);break;case 4:M.Mat4.scaleUniformly(Or,Or,1.2*v),_t.a.addPrimitive(a,Or,Er);break;case 5:M.Mat4.scaleUniformly(Or,Or,1.2*v),_t.a.addPrimitive(a,Or,Ar),M.Mat4.mul(Or,Or,M.Mat4.rotZ90),a.currentGroup+=1,_t.a.addPrimitive(a,Or,Ar);break;case 6:M.Mat4.mul(Or,Or,M.Mat4.rotZY90),M.Mat4.scale(Or,Or,M.Vec3.set(wr,v,v,v/2)),_t.a.addPrimitive(a,Or,jr);break;case 7:M.Mat4.scaleUniformly(Or,Or,v),M.Mat4.mul(Or,Or,M.Mat4.rotZY90),_t.a.addPrimitive(a,Or,Dr);break;case 8:M.Mat4.mul(Or,Or,M.Mat4.rotZY90),M.Mat4.scale(Or,Or,M.Vec3.set(wr,1.4*v,1.4*v,1.4*v)),_t.a.addPrimitive(a,Or,Tr);break;case 3:M.Mat4.mul(Or,Or,M.Mat4.rotZY90),M.Mat4.scale(Or,Or,M.Vec3.set(wr,1.4*v,1.4*v,1.4*v)),_t.a.addPrimitive(a,Or,Ir),M.Mat4.mul(Or,Or,M.Mat4.rotY90),a.currentGroup+=1,_t.a.addPrimitive(a,Or,Ir);break;case 9:M.Mat4.mul(Or,Or,M.Mat4.rotZY90),M.Mat4.scale(Or,Or,M.Vec3.set(wr,v,v/2,v/2)),_t.a.addPrimitive(a,Or,Mr);break;case 12:M.Mat4.mul(Or,Or,M.Mat4.rotZY90),M.Mat4.scale(Or,Or,M.Vec3.set(wr,v,v,v/2)),_t.a.addPrimitive(a,Or,Mr);break;case 13:case 11:M.Mat4.mul(Or,Or,M.Mat4.rotZY90),M.Mat4.scale(Or,Or,M.Vec3.set(wr,v,v,v/2)),_t.a.addPrimitive(a,Or,kr);break;case 14:M.Mat4.mul(Or,Or,M.Mat4.rotZY90),M.Mat4.scale(Or,Or,M.Vec3.set(wr,v,v,v/2)),_t.a.addPrimitive(a,Or,Br);break;case 15:M.Mat4.mul(Or,Or,M.Mat4.rotZY90),M.Mat4.scale(Or,Or,M.Vec3.set(wr,v,v,v/2)),_t.a.addPrimitive(a,Or,Rr);break;case 10:default:M.Mat4.mul(Or,Or,M.Mat4.rotZYZ90),M.Mat4.scale(Or,Or,M.Vec3.set(wr,v/1.5,v,v/2)),_t.a.addPrimitive(a,Or,Vr)}}return _t.a.getMesh(a)}var Nr=Object(o.__assign)(Object(o.__assign)({},st.g),{detail:d.ParamDefinition.Numeric(0,{min:0,max:3,step:1},Bt.a.CustomQualityParamInfo),sizeFactor:d.ParamDefinition.Numeric(1.75,{min:0,max:10,step:.01})});function Fr(e){return Object(st.h)({defaultProps:d.ParamDefinition.getDefaultValues(Nr),createGeometry:Lr,createLocationIterator:Ur,getLoci:zr,eachLocation:Hr,setUpdateState:function(e,t,r){e.createGeometry=t.sizeFactor!==r.sizeFactor||t.detail!==r.detail}},e)}function Ur(e){var t=e.carbohydrates.elements,r=2*t.length,n=A.StructureElement.Location.create(e);return Object(Fe.a)(r,1,1,(function(e,r){var i=t[Math.floor(e/2)],a=i.unit.rings.all[i.ringIndex];return n.unit=i.unit,n.element=i.unit.elements[a[0]],n}),!0,(function(e,t){return e%2==1}))}function zr(e,t,r){var n=e.objectId,i=e.groupId;if(r===n){var a=t.carbohydrates.elements[Math.floor(i/2)];return Object(ze.f)(t,a.unit,a.residueIndex,a.altId)}return me.EmptyLoci}function Hr(e,t,r){var n=t.carbohydrates.getElementIndices,i=!1;if(!A.StructureElement.Loci.is(e))return!1;if(!A.Structure.areEquivalent(e.structure,t))return!1;for(var a=function(e,t){if(!A.Unit.isAtomic(e))return"continue";Ee.OrderedSet.forEach(t,(function(t){for(var a=n(e,e.elements[t]),o=0,s=a.length;o<s;++o)r(Ee.Interval.ofSingleton(2*a[o]))&&(i=!0)}))},o=0,s=e.elements;o<s.length;o++){var u=s[o];a(u.unit,u.indices)}return i}var Gr=r(113);function qr(e,t,r,n,i){var a=t.carbohydrates,o=a.terminalLinks,s=a.elements,u=n.terminalLinkSizeFactor,c=A.StructureElement.Location.create(t),l={linkCount:o.length,position:function(e,t,r){var n=o[r];n.fromCarbohydrate?(M.Vec3.copy(e,s[n.carbohydrateIndex].geometry.center),n.elementUnit.conformation.position(n.elementUnit.elements[n.elementIndex],t)):(n.elementUnit.conformation.position(n.elementUnit.elements[n.elementIndex],e),M.Vec3.copy(t,s[n.carbohydrateIndex].geometry.center))},radius:function(e){var t=o[e];if(t.fromCarbohydrate){var n=s[t.carbohydrateIndex],i=n.unit.rings.all[n.ringIndex];c.unit=n.unit,c.element=n.unit.elements[i[0]]}else c.unit=t.elementUnit,c.element=t.elementUnit.elements[t.elementIndex];return r.size.size(c)*u},style:function(e){var t=o[e],r=t.elementUnit.elements[t.elementIndex],n=Object(Gr.c)(t.elementUnit.model.atomicHierarchy.atoms.type_symbol.value(r));return Gr.b.has(n)?1:0}};return Object(Re.d)(e,l,n,i)}var Wr=Object(o.__assign)(Object(o.__assign)(Object(o.__assign)({},Le.g),Re.a),{terminalLinkSizeFactor:d.ParamDefinition.Numeric(.2,{min:0,max:3,step:.01})});function Xr(e){return Object(st.h)({defaultProps:d.ParamDefinition.getDefaultValues(Wr),createGeometry:qr,createLocationIterator:Yr,getLoci:Qr,eachLocation:Kr,setUpdateState:function(e,t,r){e.createGeometry=t.terminalLinkSizeFactor!==r.terminalLinkSizeFactor||t.radialSegments!==r.radialSegments||t.linkCap!==r.linkCap}},e)}function Yr(e){var t=e.carbohydrates,r=t.elements,n=t.terminalLinks,i=n.length,a=A.StructureElement.Location.create(e);return Object(Fe.a)(i,1,1,(function(e){var t=n[e];if(t.fromCarbohydrate){var i=r[t.carbohydrateIndex],o=i.unit.rings.all[i.ringIndex];a.unit=i.unit,a.element=i.unit.elements[o[0]]}else a.unit=t.elementUnit,a.element=t.elementUnit.elements[t.elementIndex];return a}),!0)}function Qr(e,t,r){var n=e.objectId,i=e.groupId;if(r===n){var a=t.carbohydrates,o=a.terminalLinks,s=a.elements,u=o[i],c=s[u.carbohydrateIndex];return A.StructureElement.Loci.union(Object(ze.f)(t,c.unit,c.residueIndex,c.altId),Object(ze.e)(t,u.elementUnit,u.elementUnit.elements[u.elementIndex]))}return me.EmptyLoci}function Kr(e,t,r){var n=!1;if(!A.StructureElement.Loci.is(e))return!1;if(!A.Structure.areEquivalent(e.structure,t))return!1;for(var i=t.carbohydrates.getTerminalLinkIndices,a=function(e,t){if(!A.Unit.isAtomic(e))return"continue";Ee.OrderedSet.forEach(t,(function(t){for(var a=i(e,e.elements[t]),o=0,s=a.length;o<s;++o)r(Ee.Interval.ofSingleton(a[o]))&&(n=!0)}))},o=0,s=e.elements;o<s.length;o++){var u=s[o];a(u.unit,u.indices)}return n}var Zr={"carbohydrate-symbol":function(e,t){return Object(Nt.a)("Carbohydrate symbol mesh",e,t,Fr)},"carbohydrate-link":function(e,t){return Object(Nt.a)("Carbohydrate link cylinder",e,t,Xt)},"carbohydrate-terminal-link":function(e,t){return Object(Nt.a)("Carbohydrate terminal link cylinder",e,t,Xr)}},Jr=Object(o.__assign)(Object(o.__assign)(Object(o.__assign)(Object(o.__assign)({},Nr),Wt),Wr),{visuals:d.ParamDefinition.MultiSelect(["carbohydrate-symbol","carbohydrate-link","carbohydrate-terminal-link"],d.ParamDefinition.objectToOptions(Zr))});var $r=Object(Ft.b)({name:"carbohydrate",label:"Carbohydrate",description:"Displays carbohydrate symbols (3D SNFG).",factory:function(e,t){return ye.a.createMulti("Carbohydrate",e,t,Ft.c,Zr)},getParams:function(e,t){return d.ParamDefinition.clone(Jr)},defaultValues:d.ParamDefinition.getDefaultValues(Jr),defaultColorTheme:{name:"carbohydrate-symbol"},defaultSizeTheme:{name:"uniform"},isApplicable:function(e){return e.models.some((function(e){return A.Model.hasCarbohydrate(e)}))}}),en=r(91),tn=r(88);function rn(e,t){return{centerA:A.StructureElement.Location.create(e,t),centerB:A.StructureElement.Location.create(e,t)}}(function(){function e(e,t){this.unit=t,this.state=0,this.hasNext=!1,this.traceElementIndex=t.model.atomicHierarchy.derived.residue.traceElementIndex,this.polymerIt=tn.a.transientSegments(qn(t),t.elements),this.residueIt=Ee.Segmentation.transientSegments(t.model.atomicHierarchy.residueAtomSegments,t.elements),this.value=rn(e,t),this.hasNext=this.residueIt.hasNext&&this.polymerIt.hasNext}e.prototype.move=function(){if(0===this.state)for(;this.polymerIt.hasNext;)if(this.residueIt.setSegment(this.polymerIt.move()),this.residueIt.hasNext){this.residueSegment=this.residueIt.move(),this.value.centerB.element=this.traceElementIndex[this.residueSegment.index],this.state=2;break}if(2===this.state)this.residueSegment=this.residueIt.move(),this.value.centerA.element=this.value.centerB.element,this.value.centerB.element=this.traceElementIndex[this.residueSegment.index],this.residueIt.hasNext||(this.unit.model.atomicRanges.cyclicPolymerMap.has(this.residueSegment.index)?this.state=3:this.state=0);else if(3===this.state){var e=this.unit.model.atomicRanges.cyclicPolymerMap;this.value.centerA.element=this.value.centerB.element,this.value.centerB.element=this.traceElementIndex[e.get(this.residueSegment.index)],this.state=0}return this.hasNext=this.residueIt.hasNext||this.polymerIt.hasNext||3===this.state,this.value}})(),function(){function e(e,t){this.unit=t,this.state=0,this.hasNext=!1,this.polymerIt=tn.a.transientSegments(qn(t),t.elements),this.value=rn(e,t),this.hasNext=this.polymerIt.hasNext}e.prototype.move=function(){return 0===this.state&&this.polymerIt.hasNext&&(this.polymerSegment=this.polymerIt.move(),this.elementIndex=this.polymerSegment.start,this.elementIndex+1<this.polymerSegment.end?(this.value.centerB.element=this.unit.elements[this.elementIndex],this.state=1):this.state=0),1===this.state&&(this.elementIndex+=1,this.value.centerA.element=this.value.centerB.element,this.value.centerB.element=this.unit.elements[this.elementIndex],this.elementIndex+1>=this.polymerSegment.end&&(this.state=0)),this.hasNext=this.elementIndex+1<this.polymerSegment.end||this.polymerIt.hasNext,this.value}}();function nn(e,t){return{centerA:A.StructureElement.Location.create(e,t),centerB:A.StructureElement.Location.create(e,t)}}var an=function(){function e(e,t){this.unit=t,this.hasNext=!1,this.traceElementIndex=t.model.atomicHierarchy.derived.residue.traceElementIndex,this.gapIt=tn.a.transientSegments(Wn(t),t.elements),this.value=nn(e,t),this.hasNext=this.gapIt.hasNext}return e.prototype.move=function(){var e=this.unit,t=e.elements,r=e.residueIndex,n=this.gapIt.move();return this.value.centerA.element=this.traceElementIndex[r[t[n.start]]],this.value.centerB.element=this.traceElementIndex[r[t[n.end-1]]],this.hasNext=this.gapIt.hasNext,this.value},e}(),on=function(){function e(e,t){this.unit=t,this.hasNext=!1,this.gapIt=tn.a.transientSegments(Wn(t),t.elements),this.value=nn(e,t),this.hasNext=this.gapIt.hasNext}return e.prototype.move=function(){var e=this.gapIt.move();return this.value.centerA.element=this.unit.elements[e.start],this.value.centerB.element=this.unit.elements[e.end-1],this.hasNext=this.gapIt.hasNext,this.value},e}(),sn=r(181);function un(e,t,r){switch(void 0===r&&(r=!1),e.kind){case 0:return new mn(e,t,r);case 1:case 2:return new hn(e,t)}}var cn=Ne.SecondaryStructureType.create(536870912);function ln(e,t){return{center:A.StructureElement.Location.create(e,t),centerPrev:A.StructureElement.Location.create(e,t),centerNext:A.StructureElement.Location.create(e,t),first:!1,last:!1,initial:!1,final:!1,secStrucFirst:!1,secStrucLast:!1,secStrucType:cn,moleculeType:0,coarseBackboneFirst:!1,coarseBackboneLast:!1,isCoarseBackbone:!1,p0:Object(M.Vec3)(),p1:Object(M.Vec3)(),p2:Object(M.Vec3)(),p3:Object(M.Vec3)(),p4:Object(M.Vec3)(),d12:Object(M.Vec3)(),d23:Object(M.Vec3)()}}var dn=Object(M.Vec3)(),fn=Object(M.Vec3)(),pn=Object(M.Vec3)(),mn=function(){function e(e,t,r){var n;void 0===r&&(r=!1),this.unit=e,this.state=0,this.p0=Object(M.Vec3)(),this.p1=Object(M.Vec3)(),this.p2=Object(M.Vec3)(),this.p3=Object(M.Vec3)(),this.p4=Object(M.Vec3)(),this.p5=Object(M.Vec3)(),this.p6=Object(M.Vec3)(),this.d01=Object(M.Vec3)(),this.d12=Object(M.Vec3)(),this.d23=Object(M.Vec3)(),this.d34=Object(M.Vec3)(),this.hasNext=!1,this.atomicConformation=e.model.atomicConformation,this.residueAtomSegments=e.model.atomicHierarchy.residueAtomSegments,this.polymerRanges=e.model.atomicRanges.polymerRanges,this.traceElementIndex=e.model.atomicHierarchy.derived.residue.traceElementIndex,this.directionFromElementIndex=e.model.atomicHierarchy.derived.residue.directionFromElementIndex,this.directionToElementIndex=e.model.atomicHierarchy.derived.residue.directionToElementIndex,this.moleculeType=e.model.atomicHierarchy.derived.residue.moleculeType,this.cyclicPolymerMap=e.model.atomicRanges.cyclicPolymerMap,this.polymerIt=tn.a.transientSegments(this.polymerRanges,e.elements),this.residueIt=Ee.Segmentation.transientSegments(this.residueAtomSegments,e.elements),this.value=ln(t,e),this.hasNext=this.residueIt.hasNext&&this.polymerIt.hasNext;var i=!r&&(null===(n=sn.a.get(t).value)||void 0===n?void 0:n.get(e.invariantId));if(i){var a=i.type,o=i.getIndex;this.getSecStruc=function(e){return a[o(e)]}}else this.getSecStruc=function(e){return cn}}return e.prototype.pos=function(e,t){-1!==t&&(e[0]=this.atomicConformation.x[t],e[1]=this.atomicConformation.y[t],e[2]=this.atomicConformation.z[t])},e.prototype.updateResidueSegmentRange=function(e){var t=this.residueAtomSegments.index;this.residueSegmentMin=t[this.polymerRanges[2*e.index]],this.residueSegmentMax=t[this.polymerRanges[2*e.index+1]]},e.prototype.getResidueIndex=function(e){if(e<this.residueSegmentMin)e=void 0!==(t=this.cyclicPolymerMap.get(this.residueSegmentMin))?t-(this.residueSegmentMin-e-1):this.residueSegmentMin;else if(e>this.residueSegmentMax){var t;e=void 0!==(t=this.cyclicPolymerMap.get(this.residueSegmentMax))?t+(e-this.residueSegmentMax-1):this.residueSegmentMax}return e},e.prototype.setControlPoint=function(e,t,r,n,i){var a=this.getSecStruc(i);Ne.SecondaryStructureType.is(a,4)?M.Vec3.scale(e,M.Vec3.add(e,t,M.Vec3.add(e,n,M.Vec3.add(e,r,r))),1/4):M.Vec3.copy(e,r)},e.prototype.setFromToVector=function(e,t){this.value.isCoarseBackbone?M.Vec3.set(e,1,0,0):(this.pos(fn,this.directionFromElementIndex[t]),this.pos(pn,this.directionToElementIndex[t]),M.Vec3.sub(e,pn,fn))},e.prototype.setDirection=function(e,t,r,n){M.Vec3.matchDirection(fn,t,r),M.Vec3.matchDirection(pn,n,r),M.Vec3.scale(e,M.Vec3.add(e,fn,M.Vec3.add(e,pn,M.Vec3.add(e,r,r))),1/4)},e.prototype.move=function(){var e=this.residueIt,t=this.polymerIt,r=this.value;if(0===this.state)for(;t.hasNext;)if(this.polymerSegment=t.move(),e.setSegment(this.polymerSegment),this.updateResidueSegmentRange(this.polymerSegment),e.hasNext){this.state=1;var n=this.residueAtomSegments.index[this.unit.elements[this.polymerSegment.start]],i=this.getResidueIndex(n-1);this.currSecStrucType=n===i?cn:this.getSecStruc(i),this.nextSecStrucType=this.getSecStruc(n),this.currCoarseBackbone=-1===this.directionFromElementIndex[i]||-1===this.directionToElementIndex[i],this.nextCoarseBackbone=-1===this.directionFromElementIndex[n]||-1===this.directionToElementIndex[n];break}if(1===this.state){var a=e.move().index,o=this.getResidueIndex(a-3),s=this.getResidueIndex(a-2),u=this.getResidueIndex(a-1),c=this.getResidueIndex(a+1),l=this.getResidueIndex(a+2),d=this.getResidueIndex(a+3);this.prevSecStrucType=this.currSecStrucType,this.currSecStrucType=this.nextSecStrucType,this.nextSecStrucType=a===c?cn:this.getSecStruc(c),this.prevCoarseBackbone=this.currCoarseBackbone,this.currCoarseBackbone=this.nextCoarseBackbone,this.nextCoarseBackbone=a!==c&&(-1===this.directionFromElementIndex[c]||-1===this.directionToElementIndex[c]),r.secStrucType=this.currSecStrucType,r.secStrucFirst=this.prevSecStrucType!==this.currSecStrucType,r.secStrucLast=this.currSecStrucType!==this.nextSecStrucType,r.isCoarseBackbone=this.currCoarseBackbone,r.coarseBackboneFirst=this.prevCoarseBackbone!==this.currCoarseBackbone,r.coarseBackboneLast=this.currCoarseBackbone!==this.nextCoarseBackbone,r.first=a===this.residueSegmentMin,r.last=a===this.residueSegmentMax,r.moleculeType=this.moleculeType[a],r.isCoarseBackbone=-1===this.directionFromElementIndex[a]||-1===this.directionToElementIndex[a],r.initial=a===u,r.final=a===c,r.centerPrev.element=this.traceElementIndex[u],r.center.element=this.traceElementIndex[a],r.centerNext.element=this.traceElementIndex[c],this.pos(this.p0,this.traceElementIndex[o]),this.pos(this.p1,this.traceElementIndex[s]),this.pos(this.p2,this.traceElementIndex[u]),this.pos(this.p3,this.traceElementIndex[a]),this.pos(this.p4,this.traceElementIndex[c]),this.pos(this.p5,this.traceElementIndex[l]),this.pos(this.p6,this.traceElementIndex[d]),this.setFromToVector(this.d01,u),this.setFromToVector(this.d12,a),this.setFromToVector(this.d23,c),this.setFromToVector(this.d34,l);var f=.5;a===u?(M.Vec3.scale(dn,M.Vec3.sub(dn,this.p3,this.p4),f),M.Vec3.add(this.p2,this.p3,dn),M.Vec3.add(this.p1,this.p2,dn),M.Vec3.add(this.p0,this.p1,dn)):u===s?(M.Vec3.scale(dn,M.Vec3.sub(dn,this.p2,this.p3),f),M.Vec3.add(this.p1,this.p2,dn),M.Vec3.add(this.p0,this.p1,dn)):s===o&&(M.Vec3.scale(dn,M.Vec3.sub(dn,this.p1,this.p2),f),M.Vec3.add(this.p0,this.p1,dn)),a===c?(M.Vec3.scale(dn,M.Vec3.sub(dn,this.p3,this.p2),f),M.Vec3.add(this.p4,this.p3,dn),M.Vec3.add(this.p5,this.p4,dn),M.Vec3.add(this.p6,this.p5,dn)):c===l?(M.Vec3.scale(dn,M.Vec3.sub(dn,this.p4,this.p3),f),M.Vec3.add(this.p5,this.p4,dn),M.Vec3.add(this.p6,this.p5,dn)):l===d&&(M.Vec3.scale(dn,M.Vec3.sub(dn,this.p5,this.p4),f),M.Vec3.add(this.p6,this.p5,dn)),this.setControlPoint(r.p0,this.p0,this.p1,this.p2,s),this.setControlPoint(r.p1,this.p1,this.p2,this.p3,u),this.setControlPoint(r.p2,this.p2,this.p3,this.p4,a),this.setControlPoint(r.p3,this.p3,this.p4,this.p5,c),this.setControlPoint(r.p4,this.p4,this.p5,this.p6,l),this.setDirection(r.d12,this.d01,this.d12,this.d23),this.setDirection(r.d23,this.d12,this.d23,this.d34),e.hasNext||(this.state=0)}return this.hasNext=e.hasNext||t.hasNext,this.value},e}(),hn=function(){function e(e,t){switch(this.unit=e,this.state=0,this.hasNext=!1,this.polymerIt=tn.a.transientSegments(qn(e),e.elements),this.value=ln(t,e),M.Vec3.set(this.value.d12,1,0,0),M.Vec3.set(this.value.d23,1,0,0),e.kind){case 1:this.conformation=e.model.coarseConformation.spheres;break;case 2:this.conformation=e.model.coarseConformation.gaussians}this.hasNext=this.polymerIt.hasNext}return e.prototype.getElementIndex=function(e){return Math.min(Math.max(this.polymerSegment.start,e),this.polymerSegment.end-1)},e.prototype.pos=function(e,t){var r=this.unit.elements[t];e[0]=this.conformation.x[r],e[1]=this.conformation.y[r],e[2]=this.conformation.z[r]},e.prototype.move=function(){if(0===this.state)for(;this.polymerIt.hasNext;)if(this.polymerSegment=this.polymerIt.move(),this.elementIndex=this.polymerSegment.start,this.elementIndex<this.polymerSegment.end){this.state=1;break}if(1===this.state){var e=this.getElementIndex(this.elementIndex-2),t=this.getElementIndex(this.elementIndex-1),r=this.getElementIndex(this.elementIndex+1),n=this.getElementIndex(this.elementIndex+2);this.value.centerPrev.element=this.value.center.unit.elements[t],this.value.center.element=this.value.center.unit.elements[this.elementIndex],this.value.centerNext.element=this.value.center.unit.elements[r],this.pos(this.value.p0,e),this.pos(this.value.p1,t),this.pos(this.value.p2,this.elementIndex),this.pos(this.value.p3,r),this.pos(this.value.p4,n);var i=.5;this.elementIndex===t?(M.Vec3.scale(dn,M.Vec3.sub(dn,this.value.p2,this.value.p3),i),M.Vec3.add(this.value.p1,this.value.p2,dn),M.Vec3.add(this.value.p0,this.value.p1,dn)):t===e&&(M.Vec3.scale(dn,M.Vec3.sub(dn,this.value.p1,this.value.p2),i),M.Vec3.add(this.value.p0,this.value.p1,dn)),this.elementIndex===r?(M.Vec3.scale(dn,M.Vec3.sub(dn,this.value.p2,this.value.p1),i),M.Vec3.add(this.value.p3,this.value.p2,dn),M.Vec3.add(this.value.p4,this.value.p3,dn)):r===n&&(M.Vec3.scale(dn,M.Vec3.sub(dn,this.value.p3,this.value.p2),i),M.Vec3.add(this.value.p4,this.value.p3,dn)),this.value.first=this.elementIndex===this.polymerSegment.start,this.value.last=this.elementIndex===this.polymerSegment.end-1,this.elementIndex+1>=this.polymerSegment.end&&(this.state=0)}return this.hasNext=this.elementIndex+1<this.polymerSegment.end||this.polymerIt.hasNext,this.elementIndex+=1,this.value},e}(),gn=r(70),vn=M.Vec3.fromArray,bn=M.Vec3.toArray,yn=M.Vec3.normalize,_n=M.Vec3.sub,Sn=M.Vec3.spline,xn=M.Vec3.slerp,On=M.Vec3.copy,wn=M.Vec3.cross,Cn=M.Vec3.orthogonalize,jn=M.Vec3.matchDirection;function Pn(e){var t=e+1,r=3*t;return{curvePoints:new Float32Array(r),tangentVectors:new Float32Array(r),normalVectors:new Float32Array(r),binormalVectors:new Float32Array(r),widthValues:new Float32Array(t),heightValues:new Float32Array(t),linearSegments:e}}function En(e,t,r,n){!function(e,t,r,n){for(var i=e.curvePoints,a=e.tangentVectors,o=e.linearSegments,s=t.p0,u=t.p1,c=t.p2,l=t.p3,d=t.p4,f=t.secStrucFirst,p=t.secStrucLast,m=1-n,h=f?.5:r,g=p?.5:r,v=0;v<=o;++v){var b=1*v/o;if(b<m){var y=Object(gn.b)(h,r,b);Sn(Tn,s,u,c,l,b+n,y),Sn(An,s,u,c,l,b+n+.01,h),Sn(Dn,s,u,c,l,b+n-.01,h)}else{y=Object(gn.b)(r,g,b);Sn(Tn,u,c,l,d,b-m,y),Sn(An,u,c,l,d,b-m+.01,y),Sn(Dn,u,c,l,d,b-m-.01,y)}bn(Tn,i,3*v),yn(Mn,_n(Mn,An,Dn)),bn(Mn,a,3*v)}}(e,t,r,n),function(e,t){var r=e.curvePoints,n=e.tangentVectors,i=e.normalVectors,a=e.binormalVectors,o=t.d12,s=t.d23,u=r.length/3;vn(Rn,n,0),vn(Ln,n,3*(u-1)),Cn(Nn,Rn,o),Cn(Fn,Ln,s),jn(Fn,Fn,Nn),On(Vn,Nn);for(var c=0;c<u;++c){var l=0===c?0:1/(u-c);vn(Mn,n,3*c),Cn(kn,Mn,xn(In,Vn,Fn,l)),bn(kn,i,3*c),On(Vn,kn),yn(Bn,wn(Bn,Mn,kn)),bn(Bn,a,3*c)}}(e,t)}var An=Object(M.Vec3)(),Dn=Object(M.Vec3)(),Tn=Object(M.Vec3)();var In=Object(M.Vec3)(),Mn=Object(M.Vec3)(),kn=Object(M.Vec3)(),Bn=Object(M.Vec3)(),Vn=Object(M.Vec3)(),Rn=Object(M.Vec3)(),Ln=Object(M.Vec3)(),Nn=Object(M.Vec3)(),Fn=Object(M.Vec3)();function Un(e,t,r,n,i,a,o,s){for(var u=e.widthValues,c=e.heightValues,l=e.linearSegments,d=1-s,f=0;f<=l;++f){var p=1*f/l;p<d?(u[f]=Object(gn.b)(t,r,p+s),c[f]=Object(gn.b)(i,a,p+s)):(u[f]=Object(gn.b)(r,n,p-d),c[f]=Object(gn.b)(a,o,p-d))}}var zn,Hn,Gn;function qn(e){switch(e.kind){case 0:return e.model.atomicRanges.polymerRanges;case 1:return e.model.coarseHierarchy.spheres.polymerRanges;case 2:return e.model.coarseHierarchy.gaussians.polymerRanges}}function Wn(e){switch(e.kind){case 0:return e.model.atomicRanges.gapRanges;case 1:return e.model.coarseHierarchy.spheres.gapRanges;case 2:return e.model.coarseHierarchy.gaussians.gapRanges}}function Xn(e,t,r){var n=e.objectId,i=e.instanceId,a=e.groupId;if(r===n){var o=t.structure,s=t.group.units[i];if(A.Unit.isAtomic(s))return Object(ze.g)(o,s,s.polymerElements[a]);var u=s.elements,c=s.polymerElements[a],l=Ee.OrderedSet.indexOf(u,c);if(-1!==l){var d=Ee.OrderedSet.ofSingleton(l);return A.StructureElement.Loci(o,[{unit:s,indices:d}])}}return me.EmptyLoci}function Yn(e,t,r,n,i,a){for(var o=-1,s=-1,u=i;u<=a;u++){if(!((l=r[u])<0)&&(o=Ee.OrderedSet.indexOf(t,l))>=0){s=u;break}}if(o<0)return!1;var c=o;for(u=a;u>s;u--){var l;if(!((l=r[u])<0)){var d=Ee.OrderedSet.indexOf(t,l);if(d>=0){c=d;break}}}return n(Ee.Interval.ofRange(e+o,e+c))}function Qn(e,t,r,n,i){var a=!1,o=i.unit.elements,s=i.unit.model.atomicHierarchy.derived.residue.traceElementIndex,u=i.unit.model.atomicHierarchy.residueAtomSegments.index,c=r(i.unit);if(Ee.Interval.is(i.indices))a=0===Ee.Interval.start(i.indices)&&Ee.Interval.end(i.indices)===i.unit.elements.length?n(Ee.Interval.ofBounds(e,e+t))||a:Yn(e,c,s,n,p=u[o[Ee.Interval.min(i.indices)]],m=u[o[Ee.Interval.max(i.indices)]])||a;else for(var l=i.indices,d=0,f=l.length;d<f;d++){for(var p,m=p=u[o[l[d]]],h=d+1;h<f;){var g=u[o[l[h]]];if(g-m>1)break;m=g,h++}d=h-1,a=Yn(e,c,s,n,p,m)||a}return a}function Kn(e){return e.polymerElements}function Zn(e,t,r){var n=!1;if(!A.StructureElement.Loci.is(e))return!1;var i=t.structure,a=t.group;if(!A.Structure.areEquivalent(e.structure,i))return!1;for(var o=a.units[0].polymerElements.length,s=0,u=e.elements;s<u.length;s++){var c=u[s];if(a.unitIndexMap.has(c.unit.id)){var l=a.unitIndexMap.get(c.unit.id)*o;if(A.Unit.isAtomic(c.unit))n=Qn(l,o,Kn,r,c)||n;else if(Ee.Interval.is(c.indices)){var d=l+Ee.Interval.start(c.indices),f=l+Ee.Interval.end(c.indices);n=r(Ee.Interval.ofBounds(d,f))||n}else for(var p=0,m=c.indices.length;p<m;p++){d=c.indices[p];for(var h=p+1;h<m&&c.indices[h]===d;)h++;p=h-1;f=c.indices[p];n=r(Ee.Interval.ofRange(l+d,l+f))||n}}}return n}function Jn(e,t,r){var n=e.objectId,i=e.instanceId,a=e.groupId;if(r===n){var o=t.structure,s=t.group.units[i],u=Ee.OrderedSet.indexOf(s.elements,s.gapElements[a]),c=Ee.OrderedSet.indexOf(s.elements,s.gapElements[a%2?a-1:a+1]);if(-1!==u&&-1!==c)return A.Bond.Loci(o,[A.Bond.Location(o,s,u,o,s,c),A.Bond.Location(o,s,c,o,s,u)])}return me.EmptyLoci}function $n(e,t,r){var n=!1;if(A.Bond.isLoci(e)){var i=t.structure,a=t.group;if(!A.Structure.areRootsEquivalent(e.structure,i))return!1;e=A.Bond.remapLoci(e,i);for(var o=a.units[0].gapElements.length,s=0,u=e.bonds;s<u.length;s++){var c=u[s],l=a.unitIndexMap.get(c.aUnit.id);if(void 0!==l){var d=Ee.OrderedSet.indexOf(c.aUnit.gapElements,c.aUnit.elements[c.aIndex]),f=Ee.OrderedSet.indexOf(c.bUnit.gapElements,c.bUnit.elements[c.bIndex]);-1!==d&&-1!==f&&r(Ee.Interval.ofSingleton(l*o+d))&&(n=!0)}}}else if(A.StructureElement.Loci.is(e)){i=t.structure,a=t.group;if(!A.Structure.areRootsEquivalent(e.structure,i))return!1;e=A.StructureElement.Loci.remap(e,i);for(var p=a.units[0].gapElements.length,m=function(e){var t=a.unitIndexMap.get(e.unit.id);void 0!==t&&Ee.OrderedSet.forEach(e.indices,(function(i){var a=Ee.OrderedSet.indexOf(e.unit.gapElements,e.unit.elements[i]);-1!==a&&r(Ee.Interval.ofSingleton(t*p+a))&&(n=!0)}))},h=0,g=e.elements;h<g.length;h++){m(g[h])}}return n}function ei(e,t,r){var n=e.objectId,i=e.instanceId,a=e.groupId;if(r===n){var o=t.structure,s=t.group.units[i];if(A.Unit.isAtomic(s))return Object(ze.g)(o,s,s.nucleotideElements[a])}return me.EmptyLoci}function ti(e){return e.nucleotideElements}function ri(e,t,r){var n=!1;if(!A.StructureElement.Loci.is(e))return!1;var i=t.structure,a=t.group;if(!A.Structure.areEquivalent(e.structure,i))return!1;var o=a.units[0];if(!A.Unit.isAtomic(o))return!1;for(var s=o.nucleotideElements.length,u=0,c=e.elements;u<c.length;u++){var l=c[u];if(A.Unit.isAtomic(l.unit)&&a.unitIndexMap.has(l.unit.id)){var d=a.unitIndexMap.get(l.unit.id)*s;A.Unit.isAtomic(l.unit)&&(n=Qn(d,s,ti,r,l)||n)}}return n}(zn||(zn={})).fromGroup=function(e){var t=e.group,r=e.structure,n=t.units[0].polymerElements,i=n.length,a=t.units.length,o=A.StructureElement.Location.create(r);return Object(Fe.a)(i,a,1,(function(e,r){var i=t.units[r];return o.unit=i,o.element=n[e],o}))},(Hn||(Hn={})).fromGroup=function(e){var t=e.group,r=e.structure,n=t.units[0].gapElements,i=n.length,a=t.units.length,o=A.StructureElement.Location.create(r);return Object(Fe.a)(i,a,1,(function(e,r){var i=t.units[r];return o.unit=i,o.element=n[e],o}))},(Gn||(Gn={})).fromGroup=function(e){var t=e.group,r=e.structure,n=t.units[0],i=A.Unit.isAtomic(n)?n.nucleotideElements:[],a=i.length,o=t.units.length,s=A.StructureElement.Location.create(r);return Object(Fe.a)(a,o,1,(function(e,r){var n=t.units[r];return s.unit=n,s.element=i[e],s}))};var ni=M.Vec3.zero(),ii=M.Vec3.zero(),ai=M.Vec3.zero(),oi=M.Vec3.zero(),si=M.Vec3.zero(),ui=M.Vec3.zero(),ci=M.Vec3.zero(),li=M.Vec3.zero(),di=M.Vec3.zero(),fi=M.Vec3.zero(),pi=M.Mat4.identity(),mi=M.Vec3.zero(),hi=Object($t.a)(),gi={sizeFactor:d.ParamDefinition.Numeric(.2,{min:0,max:10,step:.01}),radialSegments:d.ParamDefinition.Numeric(16,{min:2,max:56,step:2},Bt.a.CustomQualityParamInfo)};d.ParamDefinition.getDefaultValues(gi);function vi(e,t,r,n,i,a){if(!A.Unit.isAtomic(t))return Ve.a.createEmpty(a);var o=t.nucleotideElements.length;if(!o)return Ve.a.createEmpty(a);for(var s=i.sizeFactor,u=i.radialSegments,c=o*(hi.vertices.length/3+2*u),l=_t.a.createState(c,c/4,a),d=t.elements,f=t.model,p=f.atomicHierarchy,m=p.chainAtomSegments,h=p.residueAtomSegments,g=p.atoms,v=p.index,b=f.atomicHierarchy.derived.residue,y=b.moleculeType,_=b.traceElementIndex,S=g.label_comp_id,x=t.conformation.invariantPosition,O=Ee.Segmentation.transientSegments(m,d),w=Ee.Segmentation.transientSegments(h,d),C={radiusTop:1*s,radiusBottom:1*s,radialSegments:u,bottomCap:!0},j=0;O.hasNext;)for(w.setSegment(O.move());w.hasNext;){var P=w.move().index;if(Object(Ne.isNucleic)(y[P])){var E=S.value(h.offsets[P]),D=-1,I=-1,k=-1,B=-1,V=-1,R=-1,L=4.5,N=2.5*s,F=Object(Ne.isPurineBase)(E),U=Object(Ne.isPyrimidineBase)(E);if(!F&&!U){var z=v.findAtomOnResidue(P,"C4"),H=v.findAtomOnResidue(P,"N9");-1!==z&&-1!==H&&M.Vec3.distance(x(z,ni),x(H,ii))<1.6?F=!0:U=!0}F?(L=4.5,D=v.findAtomOnResidue(P,"N1"),I=v.findAtomOnResidue(P,"C4"),k=v.findAtomOnResidue(P,"C6"),B=v.findAtomOnResidue(P,"C2"),V=v.findAtomOnResidue(P,"N9"),R=_[P]):U&&(L=3,D=v.findAtomOnResidue(P,"N3"),I=v.findAtomOnResidue(P,"C6"),k=v.findAtomOnResidue(P,"C4"),B=v.findAtomOnResidue(P,"C2"),-1===(V=v.findAtomOnResidue(P,"N1"))&&(V=v.findAtomOnResidue(P,"C1")),R=_[P]),-1!==V&&-1!==R&&(x(V,si),x(R,ui),l.currentGroup=j,Object(en.a)(l,si,ui,1,C),-1!==D&&-1!==I&&-1!==k&&-1!==B&&(x(D,ni),x(I,ii),x(k,ai),x(B,oi),M.Vec3.normalize(ci,M.Vec3.sub(ci,ii,ni)),M.Vec3.normalize(li,M.Vec3.sub(li,oi,ai)),M.Vec3.normalize(di,M.Vec3.cross(di,ci,li)),M.Mat4.targetTo(pi,ni,ii,di),M.Vec3.scaleAndAdd(fi,ni,ci,L/2-.2),M.Mat4.scale(pi,pi,M.Vec3.set(mi,4.5,N,L)),M.Mat4.setTranslation(pi,fi),_t.a.addPrimitive(l,pi,hi))),++j}}var G=_t.a.getMesh(l),q=T.g.expand(Object(T.g)(),t.boundary.sphere,1*i.sizeFactor);return G.setBoundingSphere(q),G}var bi=Object(o.__assign)(Object(o.__assign)({},Le.g),gi);function yi(e){return Object(Le.h)({defaultProps:d.ParamDefinition.getDefaultValues(bi),createGeometry:vi,createLocationIterator:Gn.fromGroup,getLoci:ei,eachLocation:ri,setUpdateState:function(e,t,r){e.createGeometry=t.sizeFactor!==r.sizeFactor||t.radialSegments!==r.radialSegments}},e)}var _i=M.Vec3.zero(),Si=M.Vec3.zero(),xi=M.Vec3.zero(),Oi=M.Vec3.zero(),wi=M.Vec3.zero(),Ci=M.Vec3.zero(),ji=M.Vec3.zero(),Pi=M.Vec3.zero(),Ei=M.Vec3.zero(),Ai=M.Vec3.zero(),Di=M.Vec3.zero(),Ti={sizeFactor:d.ParamDefinition.Numeric(.2,{min:0,max:10,step:.01}),radialSegments:d.ParamDefinition.Numeric(16,{min:2,max:56,step:2},Bt.a.CustomQualityParamInfo),detail:d.ParamDefinition.Numeric(0,{min:0,max:3,step:1},Bt.a.CustomQualityParamInfo)},Ii=(d.ParamDefinition.getDefaultValues(Ti),new Float32Array(54)),Mi=new 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Q=_t.a.getMesh(d),K=T.g.expand(Object(T.g)(),t.boundary.sphere,1*i.sizeFactor);return Q.setBoundingSphere(K),Q}var Hi=Object(o.__assign)(Object(o.__assign)({},Le.g),Ti);function Gi(e){return Object(Le.h)({defaultProps:d.ParamDefinition.getDefaultValues(Hi),createGeometry:zi,createLocationIterator:Gn.fromGroup,getLoci:ei,eachLocation:ri,setUpdateState:function(e,t,r){e.createGeometry=t.sizeFactor!==r.sizeFactor||t.radialSegments!==r.radialSegments}},e)}var qi,Wi=M.Vec3.zero(),Xi=M.Vec3.zero(),Yi=M.Vec3.zero(),Qi=M.Vec3.zero(),Ki=Object(tr.a)(3,!1);var Zi=M.Mat4.identity(),Ji=M.Vec3.zero(),$i=M.Vec3.zero(),ea=M.Vec3.zero(),ta=M.Vec3.zero(),ra=(qi||(qi=function(){for(var e=Object(er.a)(8),t=0;t<3;++t){var r=(t+1)%3;M.Vec3.set(Wi,Ki[3*t],Ki[3*t+1],-.5),M.Vec3.set(Xi,Ki[3*r],Ki[3*r+1],-.5),M.Vec3.set(Yi,Ki[3*r],Ki[3*r+1],.5),M.Vec3.set(Qi,Ki[3*t],Ki[3*t+1],.5),e.add(Wi,Xi,Yi),e.add(Yi,Qi,Wi)}return 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b=n.size.size(h.center)*s,y=4*b,_=4*b,S=6*b,x=g?f:d;M.Vec3.fromArray($i,x,0),M.Vec3.fromArray(ea,x,3),M.Vec3.normalize(ta,M.Vec3.add(ta,$i,ea)),M.Mat4.targetTo(Zi,h.p3,h.p1,ta),M.Mat4.mul(Zi,Zi,M.Mat4.rotY90Z180),M.Mat4.scale(Zi,Zi,M.Vec3.set(Ji,S,_,y)),M.Mat4.setTranslation(Zi,h.p2),_t.a.addPrimitive(c,Zi,ra)}++p}var O=_t.a.getMesh(c),w=T.g.expand(Object(T.g)(),t.boundary.sphere,1*i.sizeFactor);return O.setBoundingSphere(w),O}var aa=Object(o.__assign)(Object(o.__assign)({},Le.g),na);function oa(e){return Object(Le.h)({defaultProps:d.ParamDefinition.getDefaultValues(aa),createGeometry:ia,createLocationIterator:zn.fromGroup,getLoci:Xn,eachLocation:Zn,setUpdateState:function(e,t,r){e.createGeometry=t.sizeFactor!==r.sizeFactor}},e)}var sa={sizeFactor:d.ParamDefinition.Numeric(.2,{min:0,max:10,step:.01}),radialSegments:d.ParamDefinition.Numeric(16,{min:2,max:56,step:2},Bt.a.CustomQualityParamInfo)};d.ParamDefinition.getDefaultValues(sa);function ua(e,t,r,n,i,a){var o=t.gapElements.length;if(!o)return Ve.a.createEmpty(a);for(var s=i.sizeFactor,u=i.radialSegments,c=10*u*2*o*2,l=_t.a.createState(c,c/10,a),d=t.conformation.invariantPosition,f=M.Vec3.zero(),p=M.Vec3.zero(),m={radiusTop:1,radiusBottom:1,topCap:!0,bottomCap:!0,radialSegments:u},h=0,g=function(e,t){switch(t.kind){case 0:return new an(e,t);case 1:case 2:return new on(e,t)}}(r,t);g.hasNext;){var v=g.move(),b=v.centerA,y=v.centerB;b.element===y.element||(d(b.element,f),d(y.element,p),m.radiusTop=m.radiusBottom=n.size.size(b)*s,l.currentGroup=h,Object(en.c)(l,f,p,.5,10,m),m.radiusTop=m.radiusBottom=n.size.size(y)*s,l.currentGroup=h+1,Object(en.c)(l,p,f,.5,10,m)),h+=2}var _=_t.a.getMesh(l),S=T.g.expand(Object(T.g)(),t.boundary.sphere,1*i.sizeFactor);return _.setBoundingSphere(S),_}var ca=Object(o.__assign)(Object(o.__assign)({},Le.g),sa);function la(e){return 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u=t.vertices,c=t.normals,l=t.indices,d=u.elementCount;ja(va,n,e),Pa(va,va,o),ja(ga,n,e),Pa(ga,ga,s),ja(ma,i,e),Pa(ma,ma,a),ja(ya,r,e),Ea(xa,Ea(xa,ya,ma),ga),Aa(Oa,Ea(Oa,ya,ma),va),Aa(wa,Aa(wa,ya,ma),va),Ea(Ca,Aa(Ca,ya,ma),ga),o<s?(ka(u,Ca[0],Ca[1],Ca[2]),ka(u,wa[0],wa[1],wa[2]),ka(u,Oa[0],Oa[1],Oa[2]),ka(u,xa[0],xa[1],xa[2]),Ia(ha,ga)):(ka(u,xa[0],xa[1],xa[2]),ka(u,Oa[0],Oa[1],Oa[2]),ka(u,wa[0],wa[1],wa[2]),ka(u,Ca[0],Ca[1],Ca[2]),Ia(ha,va)),Ma(_a,ma,ha);for(var f=0;f<4;++f)ka(c,_a[0],_a[1],_a[2]);ka(l,d+2,d+1,d),ka(l,d,d+3,d+2)}function Ra(e,t,r,n,i,a,o,s,u,c){var l=e.currentGroup,d=e.vertices,f=e.normals,p=e.indices,m=e.groups,h=d.elementCount,g=0;s>0&&(ja(da,t,0),ja(fa,t,3*i),g=s/Da(Aa(pa,fa,da)));for(var v=0;v<=i;++v){var 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P=o[C],E=s[C],A=0;A<a;++A)Ha(Na,Ua,za,Fa,E*O[A],P*w[A]),2===a?(Xa(La,za),qa(La,La),0===A&&C%2!=0||Wa(La,La)):(l=La,d=Ua,f=za,p=P*O[A],m=E*w[A],l[0]=d[0]*p+f[0]*m,l[1]=d[1]*p+f[1]*m,l[2]=d[2]*p+f[2]*m),qa(La,La),Qa(g,Na[0],Na[1],Na[2]),Qa(v,La[0],La[1],La[2])}for(C=0;C<i;++C)for(A=0;A<a;++A)Qa(b,S+C*a+(A+1)%a,S+(C+1)*a+(A+1)%a,S+C*a+A),Qa(b,S+(C+1)*a+(A+1)%a,S+(C+1)*a+A,S+C*a+A);if(u){var D=0,T=g.elementCount;Ga(Ua,r,D),Ga(za,n,D),Ga(Fa,t,D),Ya(La,za,Ua),Qa(g,Fa[0],Fa[1],Fa[2]),Qa(v,La[0],La[1],La[2]);P=o[0],E=s[0];S=g.elementCount;for(C=0;C<a;++C)Ha(Na,Ua,za,Fa,E*O[C],P*w[C]),Qa(g,Na[0],Na[1],Na[2]),Qa(v,La[0],La[1],La[2]),Qa(b,S+(C+1)%a,S+C,T)}if(c){D=3*i,T=g.elementCount;Ga(Ua,r,D),Ga(za,n,D),Ga(Fa,t,D),Ya(La,Ua,za),Qa(g,Fa[0],Fa[1],Fa[2]),Qa(v,La[0],La[1],La[2]);P=o[i],E=s[i];S=g.elementCount;for(C=0;C<a;++C)Ha(Na,Ua,za,Fa,E*O[C],P*w[C]),Qa(g,Na[0],Na[1],Na[2]),Qa(v,La[0],La[1],La[2]),Qa(b,S+C,S+(C+1)%a,T)}var I=(i+1)*a+(u?a+1:0)+(c?a+1:0);y.a.addRepeat(_,I,h)}var 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g=a[h],v=o[h],b=0===s?v:s*(1-h/i),y=3*h;Ja(po,r,y),ro(po,po,b),Ja(fo,n,y),ro(fo,fo,g),s>0&&(Ja(uo,r,y),Ja(co,n,y),ro(mo,ao(mo,uo,co),m)),Ja(ho,t,y),Ja(go,r,y),Ja(vo,n,y),to(uo,ho,po),no(co,vo),oo(c,uo[0],uo[1],uo[2]),oo(l,co[0],co[1],co[2]),eo(uo,ho,po),oo(c,uo[0],uo[1],uo[2]),oo(l,co[0],co[1],co[2]),to(uo,ho,po),io(co,vo),oo(c,uo[0],uo[1],uo[2]),oo(l,co[0],co[1],co[2]),eo(uo,ho,po),oo(c,uo[0],uo[1],uo[2]),oo(l,co[0],co[1],co[2])}for(h=0;h<i;++h)oo(d,p+4*h,p+4*(h+1)+1,p+4*h+1),oo(d,p+4*h,p+4*(h+1),p+4*(h+1)+1),oo(d,p+4*h+2+1,p+4*(h+1)+2+1,p+4*h+2),oo(d,p+4*h+2,p+4*(h+1)+2+1,p+4*(h+1)+2);h=0;for(var _=4*(i+1);h<_;++h)so(f,u)}var yo={sizeFactor:d.ParamDefinition.Numeric(.2,{min:0,max:10,step:.01}),aspectRatio:d.ParamDefinition.Numeric(5,{min:.1,max:10,step:.1}),arrowFactor:d.ParamDefinition.Numeric(1.5,{min:0,max:3,step:.1}),detail:d.ParamDefinition.Numeric(0,{min:0,max:3,step:1},Bt.a.CustomQualityParamInfo),linearSegments:d.ParamDefinition.Numeric(8,{min:1,max:48,step:1},Bt.a.CustomQualityParamInfo),radialSegments:d.ParamDefinition.Numeric(16,{min:2,max:56,step:2},Bt.a.CustomQualityParamInfo)},_o=(d.ParamDefinition.getDefaultValues(yo),Object(M.Vec3)());function So(e,t,r,n,i,a){var o,s,u,c=t.polymerElements.length;if(!c)return Ve.a.createEmpty(a);for(var l=i.sizeFactor,d=i.detail,f=i.linearSegments,p=i.radialSegments,m=i.aspectRatio,h=i.arrowFactor,g=f*p*c+(p+1)*c*2,v=_t.a.createState(g,g/10,a),b=A.Unit.isCoarse(t),y=Pn(f),_=y.curvePoints,S=y.normalVectors,x=y.binormalVectors,O=y.widthValues,w=y.heightValues,C=0,j=un(t,r);j.hasNext;){var P=j.move();v.currentGroup=C;var E=Object(Ne.isNucleic)(P.moleculeType),D=Ne.SecondaryStructureType.is(P.secStrucType,4),I=Ne.SecondaryStructureType.is(P.secStrucType,2),k=E?.3:.5;En(y,P,I?.9:.5,k);var B=n.size.size(P.centerPrev)*l,V=n.size.size(P.center)*l,R=n.size.size(P.centerNext)*l;b&&(B*=m/2,V*=m/2,R*=m/2);var L=P.secStrucFirst||P.coarseBackboneFirst||P.first,N=P.secStrucLast||P.coarseBackboneLast||P.last,F=f;if(P.initial){var U=f-(F=Math.max(Math.round(f*k),1));_.copyWithin(0,3*U),x.copyWithin(0,3*U),S.copyWithin(0,3*U),M.Vec3.fromArray(_o,_,3),M.Vec3.normalize(_o,M.Vec3.sub(_o,P.p2,_o)),M.Vec3.scaleAndAdd(_o,P.p2,_o,2*V),M.Vec3.toArray(_o,_,0)}else P.final&&(F=Math.max(Math.round(f*(1-k)),1),M.Vec3.fromArray(_o,_,3*F-3),M.Vec3.normalize(_o,M.Vec3.sub(_o,P.p2,_o)),M.Vec3.scaleAndAdd(_o,P.p2,_o,2*V),M.Vec3.toArray(_o,_,3*F));if(!0===P.initial&&!0===P.final)Object(St.a)(v,P.p2,2*V,d);else if(D){var z=B*m,H=V*m,G=R*m,q=P.secStrucLast?H*h:0;Un(y,B,V,R,z,H,G,k),2===p?bo(v,_,S,x,F,O,w,q):Ra(v,_,S,x,F,O,w,q,L,N)}else{z=void 0,H=void 0,G=void 0;if(I&&!P.isCoarseBackbone?(z=B*m,H=V*m,G=R*m):E&&!P.isCoarseBackbone?(B=(o=[z=B*m,B])[0],z=o[1],V=(s=[H=V*m,V])[0],H=s[1],R=(u=[G=R*m,R])[0],G=u[1]):(z=B,H=V,G=R),Un(y,B,V,R,z,H,G,k),2===p)if(E&&!P.isCoarseBackbone){for(var W=0,X=x.length;W<X;W++)x[W]*=-1;bo(v,_,x,S,F,w,O,0)}else bo(v,_,S,x,F,O,w,0);else 4===p?Ra(v,_,S,x,F,O,w,0,L,N):Za(v,_,S,x,F,p,O,w,L,N)}++C}var Y=_t.a.getMesh(v),Q=T.g.expand(Object(T.g)(),t.boundary.sphere,1*i.sizeFactor);return Y.setBoundingSphere(Q),Y}var xo=Object(o.__assign)(Object(o.__assign)({},Le.g),yo);function Oo(e){return Object(Le.h)({defaultProps:d.ParamDefinition.getDefaultValues(xo),createGeometry:So,createLocationIterator:zn.fromGroup,getLoci:Xn,eachLocation:Zn,setUpdateState:function(e,t,r,n,i,a,o){e.createGeometry=t.sizeFactor!==r.sizeFactor||t.detail!==r.detail||t.linearSegments!==r.linearSegments||t.radialSegments!==r.radialSegments||t.aspectRatio!==r.aspectRatio||t.arrowFactor!==r.arrowFactor;var s=sn.a.get(a.structure).version;e.info.secondaryStructureHash!==s&&(e.createGeometry=!0,e.info.secondaryStructureHash=s)}},e)}var wo={"polymer-trace":function(e,t){return Object(Lt.a)("Polymer trace mesh",e,t,Oo)},"polymer-gap":function(e,t){return Object(Lt.a)("Polymer gap cylinder",e,t,la)},"nucleotide-block":function(e,t){return Object(Lt.a)("Nucleotide block mesh",e,t,yi)},"nucleotide-ring":function(e,t){return Object(Lt.a)("Nucleotide ring mesh",e,t,Gi)},"direction-wedge":function(e,t){return Object(Lt.a)("Polymer direction 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t.units.forEach((function(e){!n&&A.Unit.isAtomic(e)&&e.nucleotideElements.length&&(n=!0),!i&&e.gapElements.length&&(i=!0)})),r.visuals.defaultValue=["polymer-trace"],n&&r.visuals.defaultValue.push("nucleotide-block"),i&&r.visuals.defaultValue.push("polymer-gap"),r},defaultValues:d.ParamDefinition.getDefaultValues(Co),defaultColorTheme:{name:"chain-id"},defaultSizeTheme:{name:"uniform"},isApplicable:function(e){return e.polymerResidueCount>0},ensureCustomProperties:{attach:function(e,t){return sn.a.attach(e,t,void 0,!0)},detach:function(e){return sn.a.ref(e,!1)}}}),Po=r(317),Eo=r(218),Ao=r(69),Do=Object(o.__assign)(Object(o.__assign)({},Le.g),{sizeFactor:d.ParamDefinition.Numeric(1,{min:0,max:10,step:.1}),detail:d.ParamDefinition.Numeric(0,{min:0,max:3,step:1},Bt.a.CustomQualityParamInfo),ignoreHydrogens:d.ParamDefinition.Boolean(!1)});function To(e){return Object(Le.h)({defaultProps:d.ParamDefinition.getDefaultValues(Do),createGeometry:Io,createLocationIterator:vt.fromGroup,getLoci:It,eachLocation:Tt,setUpdateState:function(e,t,r){e.createGeometry=t.sizeFactor!==r.sizeFactor||t.detail!==r.detail||t.ignoreHydrogens!==r.ignoreHydrogens}},e)}function Io(e,t,r,n,i,a){var o=i.detail,s=i.sizeFactor,u=t.elements,c=t.model,l=t.model.atomicHierarchy.derived.atom.atomicNumber,d=u.length,f=d*Object(yt.b)(o),p=_t.a.createState(f,f/2,a),m=Eo.a.Provider.get(c);if(!m)return Ve.a.createEmpty(a);var h=Object(M.Vec3)(),g=Object(M.Mat3)(),v=Object(M.Vec3)(),b=Object(M.Vec3)(),y=Object(M.Vec3)(),_=m.elementToAnsiotrop,S=m.data,x=S.U,O=S._schema.U.space,w=t.conformation.invariantPosition,C=A.StructureElement.Location.create(r);C.unit=t;for(var j=0;j<d;j++){var P=u[j],E=_[P];if(-1!==E&&(!i.ignoreHydrogens||!Object(ze.n)(l,P))){C.element=P,w(P,h),p.currentGroup=j,M.Tensor.toMat3(g,O,x.value(E)),M.Mat3.symmtricFromLower(g,g),M.Mat3.symmetricEigenvalues(v,g),M.Mat3.eigenvector(b,g,v[1]),M.Mat3.eigenvector(y,g,v[2]);for(var D=0;D<3;++D)v[D]=1.5958*s*Math.sqrt(Math.abs(v[D]));Object(Ao.b)(v[0],v[1],M.EPSILON)&&Object(Ao.b)(v[1],v[2],M.EPSILON)?Object(St.a)(p,h,v[0],o):Object(Po.a)(p,h,y,b,v,o)}}var I=_t.a.getMesh(p),k=T.g.expand(Object(T.g)(),t.boundary.sphere,1*s);return I.setBoundingSphere(k),I}var Mo={"ellipsoid-mesh":function(e,t){return Object(Ft.d)("Ellipsoid Mesh",e,t,To)},"intra-bond":function(e,t){return Object(Ft.d)("Intra-unit bond cylinder",e,t,ot)},"inter-bond":function(e,t){return Object(Ft.a)("Inter-unit bond 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Eo.a.Provider.isApplicable(e)}))}}),Vo=r(67),Ro=(r(180),r(64)),Lo=r(68),No=r(11),Fo={drawCount:Object(No.k)("number"),instanceCount:Object(No.k)("number"),aRadius:Object(No.a)("float32",1,0),aPosition:Object(No.a)("float32",3,0),aGroup:Object(No.a)("float32",1,0),uCurrentSlice:Object(No.j)("f"),uCurrentX:Object(No.j)("f"),uCurrentY:Object(No.j)("f"),uBboxMin:Object(No.j)("v3",!0),uBboxSize:Object(No.j)("v3",!0),uGridDim:Object(No.j)("v3",!0),uGridTexDim:Object(No.j)("v3",!0),uGridTexScale:Object(No.j)("v2",!0),uAlpha:Object(No.j)("f",!0),uResolution:Object(No.j)("f",!0),uRadiusFactorInv:Object(No.j)("f",!0),tMinDistanceTex:Object(No.i)("texture","rgba","float","nearest"),dGridTexType:Object(No.c)("string",["2d","3d"]),dCalcType:Object(No.c)("string",["density","minDistance","groupId"])},Uo=Object(Ro.g)("gaussian-density","\nprecision highp float;\n\nattribute vec3 aPosition;\nattribute float aRadius;\n\nvarying vec3 vPosition;\nvarying float vRadiusSqInv;\n\n#if 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Y(e,t){c.currentRenderItemId=-1,e.attachFramebuffer(X,0),t&&(s.viewport(0,0,N,F),s.scissor(0,0,N,F),s.clear(s.COLOR_BUFFER_BIT)),De.e.update(W,0);for(var r=0,n=0,i=0,a=0;a<A;++a)r>=k&&(r-=k,n+=E,i=0,De.e.update(W,n)),De.e.update(q,i),De.e.update(G,a),s.viewport(i,n,P,E),s.scissor(i,n,P,E),z.render(),++r,i+=P;s.flush()}return X.bind(),Zo(e),o||(o=p&&m?u.texture("image-float16","rgba","fp16","linear"):d&&f?u.texture("image-float32","rgba","float","linear"):u.texture("image-uint8","rgba","ubyte","linear")),o.define(N,F),$o(e,z),Y(o,!0),h&&(Jo(e,z),Y(U,!0),es(e,z),Y(o,!1)),{texture:o,scale:O,bbox:w,gridDim:C,gridTexDim:V,gridTexScale:R,radiusFactor:L}}function Qo(e,t,r,n){for(var i=n.resolution,a=n.radiusOffset,o=1/i,s=e.indices,u=e.x,c=e.y,l=e.z,d=e.id,f=Ee.OrderedSet.size(s),p=new Float32Array(3*f),m=new Float32Array(f),h=new Float32Array(f),g=0,v=0;v<f;++v){var b=Ee.OrderedSet.getAt(s,v);p[3*v]=u[b],p[3*v+1]=c[b],p[3*v+2]=l[b];var y=r(b)+a;g<y&&(g=y),m[v]=y,h[v]=d?d[v]:v}var _=2*g+4*i,S=T.b.expand(Object(T.b)(),t,M.Vec3.create(_,_,_)),x=T.b.scale(Object(T.b)(),S,o),O=T.b.size(Object(M.Vec3)(),x);return M.Vec3.ceil(O,O),{drawCount:f,positions:p,radii:m,groups:h,scale:M.Vec3.create(i,i,i),expandedBox:S,dim:O,maxRadius:g}}function Ko(e,t,r,n,i,a,s,u,c,l,d,f,p){if(e.namedComputeRenderables["gaussian-density"]){var m=M.Vec3.sub(Object(M.Vec3)(),s.max,s.min),h=e.namedComputeRenderables["gaussian-density"].values;De.e.updateIfChanged(h.drawCount,t),De.e.updateIfChanged(h.instanceCount,1),De.e.update(h.aRadius,n),De.e.update(h.aPosition,r),De.e.update(h.aGroup,i),De.e.updateIfChanged(h.uCurrentSlice,0),De.e.updateIfChanged(h.uCurrentX,0),De.e.updateIfChanged(h.uCurrentY,0),De.e.update(h.uBboxMin,s.min),De.e.update(h.uBboxSize,m),De.e.update(h.uGridDim,u),De.e.update(h.uGridTexDim,c),De.e.update(h.uGridTexScale,l),De.e.updateIfChanged(h.uAlpha,d),De.e.updateIfChanged(h.uResolution,f),De.e.updateIfChanged(h.uRadiusFactorInv,1/p),De.e.update(h.tMinDistanceTex,a),De.e.updateIfChanged(h.dGridTexType,a.getDepth()>0?"3d":"2d"),De.e.updateIfChanged(h.dCalcType,"density"),e.namedComputeRenderables["gaussian-density"].update()}else e.namedComputeRenderables["gaussian-density"]=function(e,t,r,n,i,a,s,u,c,l,d,f,p){var m=M.Vec3.sub(Object(M.Vec3)(),s.max,s.min),h={drawCount:De.e.create(t),instanceCount:De.e.create(1),aRadius:De.e.create(n),aPosition:De.e.create(r),aGroup:De.e.create(i),uCurrentSlice:De.e.create(0),uCurrentX:De.e.create(0),uCurrentY:De.e.create(0),uBboxMin:De.e.create(s.min),uBboxSize:De.e.create(m),uGridDim:De.e.create(u),uGridTexDim:De.e.create(c),uGridTexScale:De.e.create(l),uAlpha:De.e.create(d),uResolution:De.e.create(f),uRadiusFactorInv:De.e.create(1/p),tMinDistanceTex:De.e.create(a),dGridTexType:De.e.create(a.getDepth()>0?"3d":"2d"),dCalcType:De.e.create("density")},g=Object(o.__assign)({},Fo),v=Object(Lo.a)(e,"points",Uo,g,h);return Object(Vo.a)(v,h)}(e,t,r,n,i,a,s,u,c,l,d,f,p);return e.namedComputeRenderables["gaussian-density"]}function Zo(e){var t=e.gl,r=e.state;r.disable(t.CULL_FACE),r.enable(t.BLEND),r.disable(t.DEPTH_TEST),r.enable(t.SCISSOR_TEST),r.depthMask(!1),r.clearColor(0,0,0,0)}function Jo(e,t){var r=e.gl,n=e.state;if(De.e.update(t.values.dCalcType,"minDistance"),t.update(),n.colorMask(!1,!1,!1,!0),n.blendFunc(r.ONE,r.ONE),!e.extensions.blendMinMax)throw new Error("GPU gaussian surface calculation requires EXT_blend_minmax");n.blendEquation(e.extensions.blendMinMax.MAX)}function $o(e,t){var r=e.gl,n=e.state;De.e.update(t.values.dCalcType,"density"),t.update(),n.colorMask(!1,!1,!1,!0),n.blendFunc(r.ONE,r.ONE),n.blendEquation(r.FUNC_ADD)}function es(e,t){var r=e.gl,n=e.state;De.e.update(t.values.dCalcType,"groupId"),t.update(),n.colorMask(!0,!0,!0,!1),n.blendFunc(r.ONE,r.ZERO),n.blendEquation(r.FUNC_ADD)}var ts=r(322);function rs(e,t,r,n,i){return Object(o.__awaiter)(this,void 0,void 0,(function(){function a(){return Object(o.__awaiter)(this,void 0,void 0,(function(){var t;return Object(o.__generator)(this,(function(r){switch(r.label){case 0:t=0,r.label=1;case 1:return t<g?(function(e,t){for(var r=e;r<t;++r)for(var n=Ee.OrderedSet.getAt(d,r),i=f[n],a=p[n],o=m[n],s=v[r],u=1/(s*s),c=2*s,g=c*c,b=Math.ceil(c*l),y=Math.floor(l*(i-O[0])),_=Math.floor(l*(a-O[1])),S=Math.floor(l*(o-O[2])),x=Math.max(0,y-b),w=Math.max(0,_-b),C=Math.max(0,S-b),j=Math.min(I,y+b+2),E=Math.min(k,_+b+2),D=Math.min(B,S+b+2),T=x;T<j;++T)for(var M=L[T]-i,H=T*R,G=w;G<E;++G)for(var q=N[G]-a,W=M*M+q*q,X=G*V+H,Y=C;Y<D;++Y){var Q=F[Y]-o,K=W+Q*Q;if(K<=g){var Z=Object(ts.a)(K*u*-z),J=Y+X;P[J]+=Z,Z>U[J]&&(U[J]=Z,A[J]=h?h[r]:r)}}}(t,Math.min(t+H,g)),e.shouldUpdate?[4,e.update({message:"filling density grid",current:t,max:g})]:[3,3]):[3,4];case 2:r.sent(),r.label=3;case 3:return t+=H,[3,1];case 4:return[2]}}))}))}var s,u,c,l,d,f,p,m,h,g,v,b,y,_,S,x,O,w,C,j,P,E,A,D,I,k,B,V,R,L,N,F,U,z,H,G;return Object(o.__generator)(this,(function(e){switch(e.label){case 0:for(s=i.resolution,u=i.radiusOffset,c=i.smoothness,l=1/s,d=t.indices,f=t.x,p=t.y,m=t.z,h=t.id,g=Ee.OrderedSet.size(d),v=new Float32Array(g),b=0,y=0;y<g;++y)_=n(Ee.OrderedSet.getAt(d,y))+u,b<_&&(b=_),v[y]=_;return S=2*b+s,x=T.b.expand(Object(T.b)(),r,M.Vec3.create(S,S,S)),O=x.min,w=T.b.scale(Object(T.b)(),x,l),C=T.b.size(Object(M.Vec3)(),w),M.Vec3.ceil(C,C),j=M.Tensor.Space(C,[0,1,2],Float32Array),P=j.create(),E=M.Tensor.create(j,P),(A=j.create()).fill(-1),D=M.Tensor.create(j,A),I=C[0],k=C[1],B=C[2],R=(V=B)*k,L=Object(T.i)(C[0],O[0],s),N=Object(T.i)(C[1],O[1],s),F=Object(T.i)(C[2],O[2],s),U=j.create(),z=c,H=Math.ceil(1e5/(Math.pow(Math.pow(b,3),3)*l)),[4,a()];case 1:return e.sent(),G=M.Mat4.identity(),M.Mat4.fromScaling(G,M.Vec3.create(s,s,s)),M.Mat4.setTranslation(G,x.min),[2,{field:E,idField:D,transform:G,radiusFactor:1}]}}))}))}var ns=Object(o.__assign)({resolution:d.ParamDefinition.Numeric(1,{min:.1,max:20,step:.1},Object(o.__assign)({description:"Grid resolution/cell spacing."},Bt.a.CustomQualityParamInfo)),radiusOffset:d.ParamDefinition.Numeric(0,{min:0,max:10,step:.1},{description:"Extra/offset radius added to the atoms/coarse elements for gaussian calculation. Useful to create coarse, low resolution surfaces."}),smoothness:d.ParamDefinition.Numeric(1.5,{min:.5,max:2.5,step:.1},{description:"Smoothness of the gausian surface, lower is smoother."})},ze.a);d.ParamDefinition.getDefaultValues(ns);function is(e,t){var r=e.maxTextureSize/3;return r*r/Math.max(1,t?t.units.length/16:1)}function as(e,t,r){var n=this,i=t.lookup3d.boundary.box,a=Object(ze.d)(i,r),s=Object(ze.j)(e,t,a),u=s.position,c=s.radius;return _.b.create("Gaussian Density",(function(e){return Object(o.__awaiter)(n,void 0,void 0,(function(){return Object(o.__generator)(this,(function(t){switch(t.label){case 0:return[4,rs(e,u,i,c,a)];case 1:return[2,t.sent()]}}))}))}))}function os(e,t,r,n,i){var a=this,s=t.lookup3d.boundary.box,u=Object(ze.d)(s,r,is(n,e)),c=Object(ze.j)(e,t,u),l=c.position,d=c.radius;return _.b.create("Gaussian Density",(function(e){return Object(o.__awaiter)(a,void 0,void 0,(function(){return Object(o.__generator)(this,(function(e){return[2,Go(n,l,s,d,u,i)]}))}))}))}function ss(e,t,r,n,i,a){var s=this,u=t.lookup3d.boundary.box,c=Object(ze.d)(u,n,is(i,e)),l=Object(ze.j)(e,t,c),d=l.position,f=l.radius;return _.b.create("Gaussian Density",(function(e){return Object(o.__awaiter)(s,void 0,void 0,(function(){return Object(o.__generator)(this,(function(e){return[2,qo(i,d,u,f,r,c,a)]}))}))}))}function us(e,t){var r=this,n=e.lookup3d.boundary.box,i=Object(ze.d)(n,t),a=Object(ze.h)(e,t.ignoreHydrogens,t.traceOnly),s=a.position,u=a.radius;return _.b.create("Gaussian Density",(function(e){return Object(o.__awaiter)(r,void 0,void 0,(function(){return Object(o.__generator)(this,(function(t){switch(t.label){case 0:return[4,rs(e,s,n,u,i)];case 1:return[2,t.sent()]}}))}))}))}function cs(e,t,r,n){var i=this,a=e.lookup3d.boundary.box,s=Object(ze.d)(a,t,is(r)),u=Object(ze.h)(e,t.ignoreHydrogens,t.traceOnly),c=u.position,l=u.radius;return _.b.create("Gaussian Density",(function(e){return Object(o.__awaiter)(i,void 0,void 0,(function(){return Object(o.__generator)(this,(function(e){return[2,Go(r,c,a,l,s,n)]}))}))}))}function ls(e,t,r,n,i){var a=this,s=e.lookup3d.boundary.box,u=Object(ze.d)(s,r,is(n)),c=Object(ze.h)(e,r.ignoreHydrogens,r.traceOnly),l=c.position,d=c.radius;return _.b.create("Gaussian Density",(function(e){return Object(o.__awaiter)(a,void 0,void 0,(function(){return Object(o.__generator)(this,(function(e){return[2,qo(n,l,s,d,t,u,i)]}))}))}))}var ds=r(217),fs=r(191),ps=r(341),ms=Object(o.__assign)(Object(o.__assign)({},ns),{ignoreHydrogens:d.ParamDefinition.Boolean(!1),tryUseGpu:d.ParamDefinition.Boolean(!0)}),hs=Object(o.__assign)(Object(o.__assign)(Object(o.__assign)({},Le.g),Le.m),ms),gs=Object(o.__assign)(Object(o.__assign)(Object(o.__assign)({},st.g),st.k),ms);function vs(e){return e.extensions.colorBufferFloat&&e.extensions.textureFloat&&e.extensions.blendMinMax&&e.extensions.drawBuffers}function bs(e,t,r){if(t.resolution>1)return!1;var n=r.maxTextureSize/3,i=Object(ze.l)(e.boundary.box,t.resolution,n*n);return i.areaCells<i.maxAreaCells}function ys(e,t,r,n){return r.tryUseGpu&&n&&vs(n)&&bs(t,r,n)?function(e){return Object(Le.n)({defaultProps:d.ParamDefinition.getDefaultValues(hs),createGeometry:Os,createLocationIterator:vt.fromGroup,getLoci:It,eachLocation:Tt,setUpdateState:function(e,t,r){t.resolution!==r.resolution&&(e.createGeometry=!0),t.radiusOffset!==r.radiusOffset&&(e.createGeometry=!0),t.smoothness!==r.smoothness&&(e.createGeometry=!0),t.ignoreHydrogens!==r.ignoreHydrogens&&(e.createGeometry=!0),t.traceOnly!==r.traceOnly&&(e.createGeometry=!0),t.includeParent!==r.includeParent&&(e.createGeometry=!0)},mustRecreate:function(e,t,r){return!t.tryUseGpu||!r||!bs(e.structure,t,r)},dispose:function(e){e.vertexTexture.ref.value.destroy(),e.groupTexture.ref.value.destroy(),e.normalTexture.ref.value.destroy()}},e)}(e):function(e){return Object(Le.h)({defaultProps:d.ParamDefinition.getDefaultValues(hs),createGeometry:Ss,createLocationIterator:vt.fromGroup,getLoci:It,eachLocation:Tt,setUpdateState:function(e,t,r){t.resolution!==r.resolution&&(e.createGeometry=!0),t.radiusOffset!==r.radiusOffset&&(e.createGeometry=!0),t.smoothness!==r.smoothness&&(e.createGeometry=!0),t.ignoreHydrogens!==r.ignoreHydrogens&&(e.createGeometry=!0),t.traceOnly!==r.traceOnly&&(e.createGeometry=!0),t.includeParent!==r.includeParent&&(e.createGeometry=!0)},mustRecreate:function(e,t,r){return t.tryUseGpu&&!!r&&bs(e.structure,t,r)}},e)}(e)}function _s(e,t,r,n){return r.tryUseGpu&&n&&vs(n)&&bs(t,r,n)?function(e){return Object(st.l)({defaultProps:d.ParamDefinition.getDefaultValues(gs),createGeometry:ws,createLocationIterator:vt.fromStructure,getLoci:kt,eachLocation:Mt,setUpdateState:function(e,t,r){t.resolution!==r.resolution&&(e.createGeometry=!0),t.radiusOffset!==r.radiusOffset&&(e.createGeometry=!0),t.smoothness!==r.smoothness&&(e.createGeometry=!0),t.ignoreHydrogens!==r.ignoreHydrogens&&(e.createGeometry=!0),t.traceOnly!==r.traceOnly&&(e.createGeometry=!0)},mustRecreate:function(e,t,r){return!t.tryUseGpu||!r||!bs(e,t,r)},dispose:function(e){e.vertexTexture.ref.value.destroy(),e.groupTexture.ref.value.destroy(),e.normalTexture.ref.value.destroy()}},e)}(e):function(e){return Object(st.h)({defaultProps:d.ParamDefinition.getDefaultValues(gs),createGeometry:xs,createLocationIterator:vt.fromStructure,getLoci:kt,eachLocation:Mt,setUpdateState:function(e,t,r){t.resolution!==r.resolution&&(e.createGeometry=!0),t.radiusOffset!==r.radiusOffset&&(e.createGeometry=!0),t.smoothness!==r.smoothness&&(e.createGeometry=!0),t.ignoreHydrogens!==r.ignoreHydrogens&&(e.createGeometry=!0),t.traceOnly!==r.traceOnly&&(e.createGeometry=!0)},mustRecreate:function(e,t,r){return t.tryUseGpu&&!!r&&bs(e,t,r)}},e)}(e)}function Ss(e,t,r,n,i,a){return Object(o.__awaiter)(this,void 0,void 0,(function(){var n,s,u,c,l,d,f,p,m;return Object(o.__generator)(this,(function(o){switch(o.label){case 0:return n=i.smoothness,[4,as(r,t,i).runInContext(e.runtime)];case 1:return s=o.sent(),u=s.transform,c=s.field,l=s.idField,d=s.radiusFactor,f={isoLevel:Math.exp(-n)/d,scalarField:c,idField:l},[4,Object(ds.b)(f,a).runAsChild(e.runtime)];case 2:return p=o.sent(),Ve.a.transform(p,u),e.webgl&&!e.webgl.isWebGL2&&Ve.a.uniformTriangleGroup(p),m=T.g.expand(Object(T.g)(),t.boundary.sphere,i.radiusOffset+Object(ze.k)(t)),p.setBoundingSphere(m),[2,p]}}))}))}function xs(e,t,r,n,i){return Object(o.__awaiter)(this,void 0,void 0,(function(){var r,a,s,u,c,l,d,f,p;return Object(o.__generator)(this,(function(o){switch(o.label){case 0:return r=n.smoothness,[4,us(t,n).runInContext(e.runtime)];case 1:return a=o.sent(),s=a.transform,u=a.field,c=a.idField,l=a.radiusFactor,d={isoLevel:Math.exp(-r)/l,scalarField:u,idField:c},[4,Object(ds.b)(d,i).runAsChild(e.runtime)];case 2:return f=o.sent(),Ve.a.transform(f,s),e.webgl&&!e.webgl.isWebGL2&&Ve.a.uniformTriangleGroup(f),p=T.g.expand(Object(T.g)(),t.boundary.sphere,n.radiusOffset+Object(ze.i)(t)),f.setBoundingSphere(p),[2,f]}}))}))}function Os(e,t,r,n,i,a){return Object(o.__awaiter)(this,void 0,void 0,(function(){var n,s,u,c,l,d,f,p,m,h,g,v;return Object(o.__generator)(this,(function(o){switch(o.label){case 0:if(!e.webgl)throw new Error("webgl context required to create gaussian surface texture-mesh");return n=e.webgl,s=n.namedTextures,u=n.resources,c=n.extensions,l=c.colorBufferFloat,d=c.textureFloat,f=c.colorBufferHalfFloat,p=c.textureHalfFloat,s["gaussian-surface"]||(s["gaussian-surface"]=f&&p?u.texture("image-float16","rgba","fp16","linear"):l&&d?u.texture("image-float32","rgba","float","linear"):u.texture("image-uint8","rgba","ubyte","linear")),[4,ss(r,t,!0,i,e.webgl,s["gaussian-surface"]).runInContext(e.runtime)];case 1:return m=o.sent(),h=Math.exp(-i.smoothness)/m.radiusFactor,g=Object(ps.a)(e.webgl,m.texture,m.gridDim,m.gridTexDim,m.gridTexScale,m.transform,h,!0,null==a?void 0:a.vertexTexture.ref.value,null==a?void 0:a.groupTexture.ref.value,null==a?void 0:a.normalTexture.ref.value),v=T.g.expand(Object(T.g)(),t.boundary.sphere,i.radiusOffset+Object(ze.i)(r)),[2,fs.a.create(g.vertexCount,1,g.vertexTexture,g.groupTexture,g.normalTexture,v,a)]}}))}))}function ws(e,t,r,n,i){return Object(o.__awaiter)(this,void 0,void 0,(function(){var r,a,s,u,c,l,d,f,p,m,h,g;return Object(o.__generator)(this,(function(o){switch(o.label){case 0:if(!e.webgl)throw new Error("webgl context required to create structure gaussian surface texture-mesh");return r=e.webgl,a=r.namedTextures,s=r.resources,u=r.extensions,c=u.colorBufferFloat,l=u.textureFloat,d=u.colorBufferHalfFloat,f=u.textureHalfFloat,a["gaussian-surface"]||(a["gaussian-surface"]=d&&f?s.texture("image-float16","rgba","fp16","linear"):c&&l?s.texture("image-float32","rgba","float","linear"):s.texture("image-uint8","rgba","ubyte","linear")),[4,ls(t,!0,n,e.webgl,a["gaussian-surface"]).runInContext(e.runtime)];case 1:return p=o.sent(),m=Math.exp(-n.smoothness)/p.radiusFactor,h=Object(ps.a)(e.webgl,p.texture,p.gridDim,p.gridTexDim,p.gridTexScale,p.transform,m,!0,null==i?void 0:i.vertexTexture.ref.value,null==i?void 0:i.groupTexture.ref.value,null==i?void 0:i.normalTexture.ref.value),g=T.g.expand(Object(T.g)(),t.boundary.sphere,n.radiusOffset+Object(ze.i)(t)),[2,fs.a.create(h.vertexCount,1,h.vertexTexture,h.groupTexture,h.normalTexture,g,i)]}}))}))}var Cs=r(80);function js(e,t,r,n,i,a){return Object(o.__awaiter)(this,void 0,void 0,(function(){var n,s,u,c,l,d,f,p;return Object(o.__generator)(this,(function(o){switch(o.label){case 0:return n=i.smoothness,[4,as(r,t,i).runInContext(e.runtime)];case 1:return s=o.sent(),u=s.transform,c=s.field,l=s.idField,d={isoLevel:Math.exp(-n),scalarField:c,idField:l},[4,Object(ds.a)(d,a).runAsChild(e.runtime)];case 2:return f=o.sent(),Cs.a.transform(f,u),p=T.g.expand(Object(T.g)(),t.boundary.sphere,i.radiusOffset+Object(ze.k)(t)),f.setBoundingSphere(p),[2,f]}}))}))}var Ps=Object(o.__assign)(Object(o.__assign)(Object(o.__assign)({},Le.e),ns),{sizeFactor:d.ParamDefinition.Numeric(3,{min:0,max:10,step:.1}),lineSizeAttenuation:d.ParamDefinition.Boolean(!1),ignoreHydrogens:d.ParamDefinition.Boolean(!1)});function Es(e){return Object(Le.f)({defaultProps:d.ParamDefinition.getDefaultValues(Ps),createGeometry:js,createLocationIterator:vt.fromGroup,getLoci:It,eachLocation:Tt,setUpdateState:function(e,t,r){t.resolution!==r.resolution&&(e.createGeometry=!0),t.radiusOffset!==r.radiusOffset&&(e.createGeometry=!0),t.smoothness!==r.smoothness&&(e.createGeometry=!0),t.ignoreHydrogens!==r.ignoreHydrogens&&(e.createGeometry=!0),t.traceOnly!==r.traceOnly&&(e.createGeometry=!0),t.includeParent!==r.includeParent&&(e.createGeometry=!0)}},e)}var As={"gaussian-surface-mesh":function(e,t){return Object(Lt.a)("Gaussian surface mesh",e,t,ys)},"structure-gaussian-surface-mesh":function(e,t){return Object(Ft.a)("Structure-Gaussian surface mesh",e,t,_s)},"gaussian-surface-wireframe":function(e,t){return Object(Lt.a)("Gaussian surface wireframe",e,t,Es)}},Ds=Object(o.__assign)(Object(o.__assign)(Object(o.__assign)({},hs),Ps),{visuals:d.ParamDefinition.MultiSelect(["gaussian-surface-mesh"],d.ParamDefinition.objectToOptions(As))});var Ts=Object(Ft.b)({name:"gaussian-surface",label:"Gaussian Surface",description:"Displays a gaussian molecular surface.",factory:function(e,t){return ye.a.createMulti("Gaussian Surface",e,t,Ft.c,As)},getParams:function(e,t){return d.ParamDefinition.clone(Ds)},defaultValues:d.ParamDefinition.getDefaultValues(Ds),defaultColorTheme:{name:"chain-id"},defaultSizeTheme:{name:"uniform"},isApplicable:function(e){return e.elementCount>0}}),Is=r(216),Ms=r(290),ks=Object(o.__assign)(Object(o.__assign)({},st.i),{background:d.ParamDefinition.Boolean(!0),backgroundMargin:d.ParamDefinition.Numeric(0,{min:0,max:1,step:.01}),backgroundColor:d.ParamDefinition.Color(J.a.black),backgroundOpacity:d.ParamDefinition.Numeric(.5,{min:0,max:1,step:.01}),level:d.ParamDefinition.Select("residue",[["chain","Chain"],["residue","Residue"],["element","Element"]]),chainScale:d.ParamDefinition.Numeric(10,{min:0,max:20,step:.1}),residueScale:d.ParamDefinition.Numeric(1,{min:0,max:20,step:.1}),elementScale:d.ParamDefinition.Numeric(.5,{min:0,max:20,step:.1})});function Bs(e){return Object(st.j)({defaultProps:d.ParamDefinition.getDefaultValues(ks),createGeometry:Vs,createLocationIterator:vt.fromStructure,getLoci:kt,eachLocation:Mt,setUpdateState:function(e,t,r){e.createGeometry=t.level!==r.level||"chain"===t.level&&t.chainScale!==r.chainScale||"residue"===t.level&&t.residueScale!==r.residueScale||"element"===t.level&&t.elementScale!==r.elementScale}},e)}function Vs(e,t,r,n,i){switch(n.level){case"chain":return function(e,t,r,n,i){for(var a=A.StructureElement.Location.create(t),o=t.units,s=t.serialMapping,u=A.StructureProperties.chain,c=u.auth_asym_id,l=u.label_asym_id,d=s.cumulativeUnitElementCount,f=o.length,p=n.chainScale,m=Is.a.create(n,f,f/2,i),h=0,g=o.length;h<g;++h){var v=o[h];a.unit=v,a.element=v.elements[0];var b=v.lookup3d.boundary.sphere,y=b.center,_=b.radius;M.Vec3.transformMat4(Rs,y,v.conformation.operator.matrix);var S=c(a),x=l(a),O=S===x?x:x+" ["+S+"]";m.add(O,Rs[0],Rs[1],Rs[2],_,p,d[h])}return m.getText()}(0,t,0,n,i);case"residue":return function(e,t,r,n,i){for(var a=A.StructureElement.Location.create(t),o=t.units,s=t.serialMapping,u=A.StructureProperties.atom.label_comp_id,c=A.StructureProperties.residue.auth_seq_id,l=s.cumulativeUnitElementCount,d=2*t.polymerResidueCount,f=n.residueScale,p=Is.a.create(n,d,d/2,i),m=0,h=o.length;m<h;++m){var g=o[m],v=g.conformation.position,b=g.elements;a.unit=g,a.element=g.elements[0];for(var y=g.model.atomicHierarchy.residueAtomSegments.index,_=l[m],S=0,x=b.length;S<x;){var O=S,w=y[b[S]];for(S++;S<x&&y[b[S]]===w;)S++;Ls.reset();for(var C=O;C<S;C++)v(b[C],Rs),Ls.includePosition(Rs);Ls.finishedIncludeStep();for(C=O;C<S;C++)v(b[C],Rs),Ls.radiusPosition(Rs);a.element=b[O];var j=Ls.getSphere(),P=j.center,E=j.radius,D=c(a),T=u(a)+" "+D;p.add(T,P[0],P[1],P[2],E,f,_+O)}}return p.getText()}(0,t,0,n,i);case"element":return function(e,t,r,n,i){for(var a=A.StructureElement.Location.create(t),o=t.units,s=t.serialMapping,u=A.StructureProperties.atom,c=u.label_atom_id,l=u.label_alt_id,d=s.cumulativeUnitElementCount,f=Object(Ms.a)({},{scale:1}),p=t.elementCount,m=n.elementScale,h=Is.a.create(n,p,p/2,i),g=0,v=o.length;g<v;++g){var b=o[g],y=b.conformation.position,_=b.elements;a.unit=b;for(var S=d[g],x=0,O=_.length;x<O;x++){a.element=_[x],y(a.element,Rs);var w=c(a),C=l(a),j=C?w+"%"+C:w;h.add(j,Rs[0],Rs[1],Rs[2],f.size(a),m,S+x)}}return h.getText()}(0,t,0,n,i)}}var Rs=Object(M.Vec3)(),Ls=new he.a("98");var Ns={"label-text":function(e,t){return Object(Ft.a)("Label text",e,t,Bs)}},Fs=Object(o.__assign)(Object(o.__assign)({},ks),{visuals:d.ParamDefinition.MultiSelect(["label-text"],d.ParamDefinition.objectToOptions(Ns))});var Us=Object(Ft.b)({name:"label",label:"Label",description:"Displays labels.",factory:function(e,t){var r=ye.a.createMulti("Label",e,t,Ft.c,Ns);return 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4:return[2]}}))}))}var f,p,m,h,g,v,b,y,_,S,x,O,w,C,j,P,E,A,D,I,k,B,V,R,L,N,F,U,z,H,G,q,W,X,Y,Q,K,Z,J,$,ee,te,re,ne,ie,ae;return Object(o.__generator)(this,(function(e){switch(e.label){case 0:return f=-1,p=Object(M.Vec3)(),m=Object(M.Vec3)(),h=Object(M.Vec3)(),g=Object(M.Vec3)(),v=a.resolution,b=a.probeRadius,y=a.probePositions,_=1/v,S=Math.max(5,2+Math.floor(b*_)),x=M.Vec3.create(n,n,n),M.Vec3.scale(x,x,2),O=Object(T.c)(t,r,x),w=O.result,null===i&&(i=O.boundary.box),C=t.indices,j=t.x,P=t.y,E=t.z,A=t.id,D=t.radius,I=Ee.OrderedSet.size(C),k=n+v,B=T.b.expand(Object(T.b)(),i,M.Vec3.create(k,k,k)),V=B.min,R=V[0],L=V[1],N=V[2],F=T.b.scale(Object(T.b)(),B,_),U=T.b.size(Object(M.Vec3)(),F),M.Vec3.ceil(U,U),z=U[0],H=U[1],G=U[2],W=(q=G)*H,X=function(e){for(var t=0,r=2*Math.PI/e,n=new Float32Array(e),i=new 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m=Ee.OrderedSet.getAt(c,p),h=u(m);f<h&&(f=h),d[m]=h+n}return{position:Object(o.__assign)(Object(o.__assign)({},a),{radius:d}),boundary:s,maxRadius:f}}(e,t,a),u=s.position,c=s.boundary,l=s.maxRadius;return _.b.create("Molecular Surface",(function(e){return Object(o.__awaiter)(n,void 0,void 0,(function(){return Object(o.__generator)(this,(function(t){switch(t.label){case 0:return[4,Ws(e,u,c,l,i,a)];case 1:return[2,t.sent()]}}))}))}))}function Ws(e,t,r,n,i,a){return Object(o.__awaiter)(this,void 0,void 0,(function(){return Object(o.__generator)(this,(function(o){return[2,Gs(e,t,r,n,i,a)]}))}))}var Xs=Object(o.__assign)(Object(o.__assign)(Object(o.__assign)({},Le.g),Hs),ze.a);function Ys(e,t,r,n,i,a){return Object(o.__awaiter)(this,void 0,void 0,(function(){var n,s,u,c,l,d,f;return Object(o.__generator)(this,(function(o){switch(o.label){case 0:return[4,qs(r,t,i).runInContext(e.runtime)];case 1:return n=o.sent(),s=n.transform,u=n.field,c=n.idField,l={isoLevel:i.probeRadius,scalarField:u,idField:c},[4,Object(ds.b)(l,a).runAsChild(e.runtime)];case 2:return d=o.sent(),Ve.a.transform(d,s),e.webgl&&!e.webgl.isWebGL2&&Ve.a.uniformTriangleGroup(d),f=T.g.expand(Object(T.g)(),t.boundary.sphere,i.probeRadius+Object(ze.k)(t)),d.setBoundingSphere(f),[2,d]}}))}))}function Qs(e){return Object(Le.h)({defaultProps:d.ParamDefinition.getDefaultValues(Xs),createGeometry:Ys,createLocationIterator:vt.fromGroup,getLoci:It,eachLocation:Tt,setUpdateState:function(e,t,r){t.resolution!==r.resolution&&(e.createGeometry=!0),t.probeRadius!==r.probeRadius&&(e.createGeometry=!0),t.probePositions!==r.probePositions&&(e.createGeometry=!0),t.ignoreHydrogens!==r.ignoreHydrogens&&(e.createGeometry=!0),t.includeParent!==r.includeParent&&(e.createGeometry=!0)}},e)}var Ks=Object(o.__assign)(Object(o.__assign)(Object(o.__assign)(Object(o.__assign)({},Le.e),Hs),ze.a),{sizeFactor:d.ParamDefinition.Numeric(1.5,{min:0,max:10,step:.1})});function Zs(e,t,r,n,i,a){return Object(o.__awaiter)(this,void 0,void 0,(function(){var n,s,u,c,l,d,f;return Object(o.__generator)(this,(function(o){switch(o.label){case 0:return[4,qs(r,t,i).runInContext(e.runtime)];case 1:return n=o.sent(),s=n.transform,u=n.field,c=n.idField,l={isoLevel:i.probeRadius,scalarField:u,idField:c},[4,Object(ds.a)(l,a).runAsChild(e.runtime)];case 2:return d=o.sent(),Cs.a.transform(d,s),f=T.g.expand(Object(T.g)(),t.boundary.sphere,i.probeRadius+Object(ze.k)(t)),d.setBoundingSphere(f),[2,d]}}))}))}function Js(e){return Object(Le.f)({defaultProps:d.ParamDefinition.getDefaultValues(Ks),createGeometry:Zs,createLocationIterator:vt.fromGroup,getLoci:It,eachLocation:Tt,setUpdateState:function(e,t,r){t.resolution!==r.resolution&&(e.createGeometry=!0),t.probeRadius!==r.probeRadius&&(e.createGeometry=!0),t.probePositions!==r.probePositions&&(e.createGeometry=!0),t.ignoreHydrogens!==r.ignoreHydrogens&&(e.createGeometry=!0),t.includeParent!==r.includeParent&&(e.createGeometry=!0)}},e)}var $s={"molecular-surface-mesh":function(e,t){return Object(Lt.a)("Molecular surface mesh",e,t,Qs)},"molecular-surface-wireframe":function(e,t){return Object(Lt.a)("Molecular surface wireframe",e,t,Js)}},eu=Object(o.__assign)(Object(o.__assign)(Object(o.__assign)({},Xs),Ks),{visuals:d.ParamDefinition.MultiSelect(["molecular-surface-mesh"],d.ParamDefinition.objectToOptions($s))});var tu=Object(Ft.b)({name:"molecular-surface",label:"Molecular Surface",description:"Displays a molecular surface.",factory:function(e,t){return ye.a.createMulti("Molecular Surface",e,t,Ft.c,$s)},getParams:function(e,t){return d.ParamDefinition.clone(eu)},defaultValues:d.ParamDefinition.getDefaultValues(eu),defaultColorTheme:{name:"chain-id"},defaultSizeTheme:{name:"uniform"},isApplicable:function(e){return e.elementCount>0}}),ru=Object(o.__assign)(Object(o.__assign)({},Le.g),{sizeFactor:d.ParamDefinition.Numeric(1,{min:0,max:2,step:.1}),detail:d.ParamDefinition.Numeric(0,{min:0,max:3,step:1},Bt.a.CustomQualityParamInfo)});function nu(e){return Object(Le.h)({defaultProps:d.ParamDefinition.getDefaultValues(ru),createGeometry:iu,createLocationIterator:au,getLoci:ou,eachLocation:su,setUpdateState:function(e,t,r){e.createGeometry=t.sizeFactor!==r.sizeFactor||t.detail!==r.detail}},e)}function iu(e,t,r,n,i,a){if(!function(e){if(A.Unit.Traits.is(e.traits,1))return!1;if(A.Unit.Traits.is(e.traits,2))return!1;if(A.Unit.isCoarse(e))return!0;if(0===e.elements.length)return!1;e.model.atomicHierarchy.derived.residue.moleculeType;var t=e.residueIndex[e.elements[0]],r=e.model.atomicHierarchy.derived.residue.moleculeType[t];return 3!==r&&2!==r}(t))return Ve.a.createEmpty(a);var o=i.detail,s=i.sizeFactor,u=_t.a.createState(256,128,a),c=t.principalAxes.boxAxes,l=c.origin,d=c.dirA,f=c.dirB,p=T.a.size(Object(M.Vec3)(),c);M.Vec3.scale(p,p,s/2);var m=M.Vec3.create(p[2],p[1],p[0]);u.currentGroup=0,Object(Po.a)(u,l,d,f,m,o+1);var h=_t.a.getMesh(u),g=T.g.expand(Object(T.g)(),t.boundary.sphere,1*i.sizeFactor);return h.setBoundingSphere(g),h}function au(e){var t=e.group,r=e.structure,n=t.units.length,i=A.StructureElement.Location.create(r);return Object(Fe.a)(1,n,1,(function(e,r){var n=t.units[r];return i.unit=n,i.element=n.elements[e],i}))}function ou(e,t,r){var n=e.objectId,i=e.instanceId;if(r===n){var a=t.structure,o=t.group.units[i],s=Ee.OrderedSet.ofBounds(0,o.elements.length);return A.StructureElement.Loci(a,[{unit:o,indices:s}])}return me.EmptyLoci}function su(e,t,r){var n=!1;if(!A.StructureElement.Loci.is(e))return!1;var i=t.structure,a=t.group;if(!A.Structure.areEquivalent(e.structure,i))return!1;for(var o=a.elements.length,s=0,u=e.elements;s<u.length;s++){var c=u[s],l=a.unitIndexMap.get(c.unit.id);void 0!==l&&Ee.OrderedSet.size(c.indices)===o&&r(Ee.Interval.ofSingleton(l))&&(n=!0)}return n}var uu={"orientation-ellipsoid-mesh":function(e,t){return Object(Lt.a)("Orientation ellipsoid mesh",e,t,nu)}},cu=Object(o.__assign)(Object(o.__assign)({},ru),{visuals:d.ParamDefinition.MultiSelect(["orientation-ellipsoid-mesh"],d.ParamDefinition.objectToOptions(uu))});var lu,du=Object(Ft.b)({name:"orientation",label:"Orientation",description:"Displays orientation ellipsoids for polymer chains.",factory:function(e,t){return ye.a.createMulti("Orientation",e,t,Ft.c,uu)},getParams:function(e,t){return d.ParamDefinition.clone(cu)},defaultValues:d.ParamDefinition.getDefaultValues(cu),defaultColorTheme:{name:"chain-id"},defaultSizeTheme:{name:"uniform"},isApplicable:function(e){return e.elementCount>0}}),fu=r(269),pu=y.a.add3,mu=y.a.add;(lu||(lu={})).create=function(e,t,r){void 0===e&&(e=2048),void 0===t&&(t=1024);var n=y.a.create(Float32Array,3,t,r?r.centerBuffer.ref.value:e),i=y.a.create(Float32Array,1,t,r?r.groupBuffer.ref.value:e);return{add:function(e,t,r,a){pu(n,e,t,r),mu(i,a)},getPoints:function(){var e=y.a.compact(n,!0),t=y.a.compact(i,!0);return fu.a.create(e,t,n.elementCount,r)}}};var hu=Object(o.__assign)(Object(o.__assign)({},Le.i),{pointSizeAttenuation:d.ParamDefinition.Boolean(!1),ignoreHydrogens:d.ParamDefinition.Boolean(!1),traceOnly:d.ParamDefinition.Boolean(!1)});function gu(e,t,r,n,i,a){var o=t.elements,s=o.length,u=lu.create(s,s/10,a),c=Object(M.Vec3)(),l=t.conformation.invariantPosition,d=Et(t,i);if(d)for(var 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d.ParamDefinition.clone(yu)},defaultValues:d.ParamDefinition.getDefaultValues(yu),defaultColorTheme:{name:"element-symbol"},defaultSizeTheme:{name:"physical"},isApplicable:function(e){return e.elementCount>0}}),Su={sizeFactor:d.ParamDefinition.Numeric(.2,{min:0,max:10,step:.01}),detail:d.ParamDefinition.Numeric(0,{min:0,max:3,step:1},Bt.a.CustomQualityParamInfo),linearSegments:d.ParamDefinition.Numeric(8,{min:1,max:48,step:1},Bt.a.CustomQualityParamInfo),radialSegments:d.ParamDefinition.Numeric(16,{min:2,max:56,step:2},Bt.a.CustomQualityParamInfo)},xu=(d.ParamDefinition.getDefaultValues(Su),Object(M.Vec3)());function Ou(e,t,r,n,i,a){var o=t.polymerElements.length;if(!o)return Ve.a.createEmpty(a);for(var s=i.sizeFactor,u=i.detail,c=i.linearSegments,l=i.radialSegments,d=c*l*o+(l+1)*o*2,f=_t.a.createState(d,d/10,a),p=Pn(c),m=p.curvePoints,h=p.normalVectors,g=p.binormalVectors,v=p.widthValues,b=p.heightValues,y=0,_=un(t,r,!0);_.hasNext;){var S=_.move();f.currentGroup=y;var x=Object(Ne.isNucleic)(S.moleculeType)?.3:.5;En(p,S,.5,x);var O=S.coarseBackboneFirst||S.first,w=S.coarseBackboneLast||S.last,C=n.size.size(S.centerPrev)*s,j=n.size.size(S.center)*s,P=n.size.size(S.centerNext)*s;Un(p,C,j,P,C,j,P,x);var E=c;if(S.initial){var A=c-(E=Math.max(Math.round(c*x),1));m.copyWithin(0,3*A),g.copyWithin(0,3*A),h.copyWithin(0,3*A),v.copyWithin(0,3*A),b.copyWithin(0,3*A),M.Vec3.fromArray(xu,m,3),M.Vec3.normalize(xu,M.Vec3.sub(xu,S.p2,xu)),M.Vec3.scaleAndAdd(xu,S.p2,xu,2*j),M.Vec3.toArray(xu,m,0)}else S.final&&(E=Math.max(Math.round(c*(1-x)),1),M.Vec3.fromArray(xu,m,3*E-3),M.Vec3.normalize(xu,M.Vec3.sub(xu,S.p2,xu)),M.Vec3.scaleAndAdd(xu,S.p2,xu,2*j),M.Vec3.toArray(xu,m,3*E));!0===S.initial&&!0===S.final?Object(St.a)(f,S.p2,2*j,u):2===l?bo(f,m,h,g,E,v,b,0):4===l?Ra(f,m,h,g,E,v,b,0,O,w):Za(f,m,h,g,E,l,v,b,O,w),++y}var D=_t.a.getMesh(f),I=T.g.expand(Object(T.g)(),t.boundary.sphere,1*i.sizeFactor);return D.setBoundingSphere(I),D}var wu=Object(o.__assign)(Object(o.__assign)({},Le.g),Su);function Cu(e){return Object(Le.h)({defaultProps:d.ParamDefinition.getDefaultValues(wu),createGeometry:Ou,createLocationIterator:zn.fromGroup,getLoci:Xn,eachLocation:Zn,setUpdateState:function(e,t,r){e.createGeometry=t.sizeFactor!==r.sizeFactor||t.detail!==r.detail||t.linearSegments!==r.linearSegments||t.radialSegments!==r.radialSegments}},e)}var ju={"polymer-tube":function(e,t){return Object(Lt.a)("Polymer tube mesh",e,t,Cu)},"polymer-gap":function(e,t){return Object(Lt.a)("Polymer gap cylinder",e,t,la)}},Pu=Object(o.__assign)(Object(o.__assign)(Object(o.__assign)({},wu),ca),{sizeFactor:d.ParamDefinition.Numeric(.2,{min:0,max:10,step:.01}),visuals:d.ParamDefinition.MultiSelect(["polymer-tube","polymer-gap"],d.ParamDefinition.objectToOptions(ju))});var Eu=Object(Ft.b)({name:"putty",label:"Putty",description:"Displays a tube smoothly following the trace atoms of polymers.",factory:function(e,t){return ye.a.createMulti("Putty",e,t,Ft.c,ju)},getParams:function(e,t){var r=d.ParamDefinition.clone(Pu),n=!1,i=!1;return t.units.forEach((function(e){!n&&A.Unit.isAtomic(e)&&e.nucleotideElements.length&&(n=!0),!i&&e.gapElements.length&&(i=!0)})),r.visuals.defaultValue=["polymer-tube"],i&&r.visuals.defaultValue.push("polymer-gap"),r},defaultValues:d.ParamDefinition.getDefaultValues(Pu),defaultColorTheme:{name:"chain-id"},defaultSizeTheme:{name:"uncertainty"},isApplicable:function(e){return e.polymerResidueCount>0}}),Au={"element-sphere":function(e,t){return Object(Lt.a)("Sphere mesh",e,t,Rt)}},Du=Object(o.__assign)({},Vt);var Tu=Object(Ft.b)({name:"spacefill",label:"Spacefill",description:"Displays atomic/coarse elements as spheres.",factory:function(e,t){return ye.a.createMulti("Spacefill",e,t,Ft.c,Au)},getParams:function(e,t){return d.ParamDefinition.clone(Du)},defaultValues:d.ParamDefinition.getDefaultValues(Du),defaultColorTheme:{name:"element-symbol"},defaultSizeTheme:{name:"physical"},isApplicable:function(e){return e.elementCount>0}}),Iu=Ne.BondType.is;function Mu(e,t,r,n,i,a){if(!A.Unit.isAtomic(t))return Cs.a.createEmpty(a);var o=A.StructureElement.Location.create(r,t),s=t.elements,u=t.bonds,c=u.edgeCount,l=u.a,d=u.b,f=u.edgeProps,p=u.offset,m=f.order,h=f.flags,g=i.sizeFactor;if(!c)return Cs.a.createEmpty(a);var v=Object(M.Vec3)(),b=t.conformation.invariantPosition,y={linkCount:2*c,referencePosition:function(e){var t,r,n=l[e],i=d[e];n>i&&(n=(t=[i,n])[0],i=t[1]),p[n+1]-p[n]==1&&(n=(r=[i,n])[0],i=r[1]);for(var a=p[n],o=p[n+1];a<o;++a){var u=d[a];if(u!==i&&u!==n)return b(s[u],v)}for(a=p[i],o=p[i+1];a<o;++a){var c=l[a];if(c!==n&&c!==i)return b(s[c],v)}return null},position:function(e,t,r){b(s[l[r]],e),b(s[d[r]],t)},style:function(e){var t=m[e],r=h[e];return Iu(r,2)||Iu(r,4)?1:2===t?2:3===t?3:0},radius:function(e){o.element=s[l[e]];var t=n.size.size(o);o.element=s[d[e]];var r=n.size.size(o);return Math.min(t,r)*g},ignore:Xe(t,i)},_=Object(Re.e)(e,y,i,a),S=T.g.expand(Object(T.g)(),t.boundary.sphere,1*g);return _.setBoundingSphere(S),_}var ku=Object(o.__assign)(Object(o.__assign)({},Le.e),qe);function Bu(e){return Object(Le.f)({defaultProps:d.ParamDefinition.getDefaultValues(ku),createGeometry:Mu,createLocationIterator:ke.fromGroup,getLoci:Qe,eachLocation:Ke,setUpdateState:function(e,t,r,n,i,a,o){e.createGeometry=t.sizeFactor!==r.sizeFactor||t.linkScale!==r.linkScale||t.linkSpacing!==r.linkSpacing||t.dashCount!==r.dashCount||t.ignoreHydrogens!==r.ignoreHydrogens||!Object(De.f)(t.includeTypes,r.includeTypes)||!Object(De.f)(t.excludeTypes,r.excludeTypes);var s=a.group.units[0],u=o.group.units[0];A.Unit.isAtomic(s)&&A.Unit.isAtomic(u)&&($e.a.areEqual(s.bonds,u.bonds)||(e.createGeometry=!0,e.updateTransform=!0,e.updateColor=!0,e.updateSize=!0))}},e)}var Vu=new A.Bond.ElementBondIterator;function Ru(e,t,r,n){for(Vu.setElement(t,r,n);Vu.hasNext;){var i=Vu.move();return i.otherUnit.conformation.position(i.otherUnit.elements[i.otherIndex],e),e}return null}var Lu=Object(M.Vec3)(),Nu=A.StructureElement.Location.create(void 0);function Fu(e,t,r,n,i){var a=t.interUnitBonds,o=a.edgeCount,s=a.edges,u=n.sizeFactor;if(!o)return Cs.a.createEmpty(i);var c={linkCount:o,referencePosition:function(e){var r,n,i,a,o=s[e];if(o.unitA<o.unitB)r=t.unitMap.get(o.unitA),n=t.unitMap.get(o.unitB),i=o.indexA,a=o.indexB;else{if(!(o.unitA>o.unitB))throw new Error("same units in createInterUnitBondLines");r=t.unitMap.get(o.unitB),n=t.unitMap.get(o.unitA),i=o.indexB,a=o.indexA}return Ru(Lu,t,r,i)||Ru(Lu,t,n,a)},position:function(e,r,n){var i=s[n],a=t.unitMap.get(i.unitA),o=t.unitMap.get(i.unitB);a.conformation.position(a.elements[i.indexA],e),o.conformation.position(o.elements[i.indexB],r)},style:function(e){var t=s[e].props.order,r=De.a.create(s[e].props.flag);return Ne.BondType.is(r,2)||Ne.BondType.is(r,4)?1:2===t?2:3===t?3:0},radius:function(e){var n=s[e];Nu.structure=t,Nu.unit=t.unitMap.get(n.unitA),Nu.element=Nu.unit.elements[n.indexA];var i=r.size.size(Nu);Nu.unit=t.unitMap.get(n.unitB),Nu.element=Nu.unit.elements[n.indexB];var a=r.size.size(Nu);return Math.min(i,a)*u},ignore:Ye(t,n)},l=Object(Re.e)(e,c,n,i),d=T.g.expand(Object(T.g)(),t.boundary.sphere,1*u);return l.setBoundingSphere(d),l}var Uu=Object(o.__assign)(Object(o.__assign)({},st.e),qe);function zu(e){return Object(st.f)({defaultProps:d.ParamDefinition.getDefaultValues(Uu),createGeometry:Fu,createLocationIterator:ke.fromStructure,getLoci:Ze,eachLocation:Je,setUpdateState:function(e,t,r){e.createGeometry=t.sizeFactor!==r.sizeFactor||t.linkScale!==r.linkScale||t.linkSpacing!==r.linkSpacing||t.dashCount!==r.dashCount||t.ignoreHydrogens!==r.ignoreHydrogens||!Object(De.f)(t.includeTypes,r.includeTypes)||!Object(De.f)(t.excludeTypes,r.excludeTypes)}},e)}var Hu={"intra-bond":function(e,t){return Object(Lt.a)("Intra-unit bond line",e,t,Bu)},"inter-bond":function(e,t){return Object(Nt.a)("Inter-unit bond line",e,t,zu)}},Gu=Object(o.__assign)(Object(o.__assign)(Object(o.__assign)({},ku),Uu),{sizeFactor:d.ParamDefinition.Numeric(1.5,{min:.01,max:10,step:.01}),unitKinds:Object(Ut.j)(["atomic"]),visuals:d.ParamDefinition.MultiSelect(["intra-bond","inter-bond"],d.ParamDefinition.objectToOptions(Hu))});var qu=Object(Ft.b)({name:"line",label:"Line",description:"Displays bonds as 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u=o.sent(),c=u.transform,l=u.texture,d=u.bbox,f=u.gridDim,p={min:0,max:1,mean:.04,sigma:.01},m=M.Mat4.mul(Object(M.Mat4)(),c,M.Mat4.fromScaling(Object(M.Mat4)(),f)),h=M.Mat4.getScaling(Object(M.Vec3)(),c),g=Wu.a.create(d,f,c,m,h,l,p,!0,i),v=T.g.expand(Object(T.g)(),t.boundary.sphere,n.radiusOffset+Object(ze.i)(t)),g.setBoundingSphere(v),[2,g]}}))}))}var Yu=Object(o.__assign)(Object(o.__assign)(Object(o.__assign)({},st.c),ns),{ignoreHydrogens:d.ParamDefinition.Boolean(!1)});function Qu(e){return Object(st.d)({defaultProps:d.ParamDefinition.getDefaultValues(Yu),createGeometry:Xu,createLocationIterator:vt.fromStructure,getLoci:kt,eachLocation:Mt,setUpdateState:function(e,t,r){t.resolution!==r.resolution&&(e.createGeometry=!0),t.radiusOffset!==r.radiusOffset&&(e.createGeometry=!0),t.smoothness!==r.smoothness&&(e.createGeometry=!0),t.ignoreHydrogens!==r.ignoreHydrogens&&(e.createGeometry=!0),t.traceOnly!==r.traceOnly&&(e.createGeometry=!0),t.includeParent!==r.includeParent&&(e.createGeometry=!0)},dispose:function(e){e.gridTexture.ref.value.destroy()}},e)}function Ku(e,t,r,n,i,a){return Object(o.__awaiter)(this,void 0,void 0,(function(){var n,s,u,c,l,d,f,p,m,h,g,v,b;return Object(o.__generator)(this,(function(o){switch(o.label){case 0:if(n=e.runtime,!(s=e.webgl))throw new Error("GaussianDensityVolume requires `webgl`");return u=a?a.gridTexture.ref.value:void 0,[4,os(r,t,i,s,u).runInContext(n)];case 1:return 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document.scrollingElement?document.scrollingElement:document.documentElement?document.documentElement:document.body},t.prototype.handleExpand=function(){try{var e=document.getElementsByTagName("body")[0],t=document.getElementsByTagName("head")[0];if(!e||!t||!this.root)return;if(this.state.isExpanded){for(var r=t.children,n=[],i=!1,a=0;a<r.length;a++)r[a]===this.expandedViewport?i=!0:"viewport"===(r[a].name||"").toLowerCase()&&n.push(r[a]);for(var o=0,s=n;o<s.length;o++){var u=s[o];t.removeChild(u)}i||t.appendChild(this.expandedViewport);var c=e.style,l=(h=this.getScrollElement()).scrollLeft,d=h.scrollTop;this.rootState={top:c.top,bottom:c.bottom,right:c.right,left:c.left,scrollTop:d,scrollLeft:l,position:c.position,overflow:c.overflow,viewports:n,zIndex:this.root.style.zIndex,width:c.width,height:c.height,maxWidth:c.maxWidth,maxHeight:c.maxHeight,margin:c.margin,marginLeft:c.marginLeft,marginRight:c.marginRight,marginTop:c.marginTop,marginBottom:c.marginBottom},c.overflow="hidden",c.position="fixed",c.top="0",c.bottom="0",c.right="0",c.left="0",c.width="100%",c.height="100%",c.maxWidth="100%",c.maxHeight="100%",c.margin="0",c.marginLeft="0",c.marginRight="0",c.marginTop="0",c.marginBottom="0"}else{for(r=t.children,a=0;a<r.length;a++)if(r[a]===this.expandedViewport){t.removeChild(this.expandedViewport);break}if(this.rootState){for(var f=this.rootState,p=0,m=f.viewports;p<m.length;p++){u=m[p];t.appendChild(u)}var 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Map,e.state.data.events.object.created.subscribe((function(e){t.addMapping(e.state,e.ref,e.obj)})),e.state.data.events.object.removed.subscribe((function(e){t.removeMapping(e.ref)&&t.events.removed.next({ref:e.ref,obj:e.obj})})),e.state.data.events.object.updated.subscribe((function(e){t.updateMapping(e.state,e.ref,e.oldObj,e.obj)&&t.events.updated.next({ref:e.ref,oldObj:e.oldObj,obj:e.obj})}))}return e.prototype.getDecorator=function(e){var t=this.plugin.state.data.tree,r=t.children.get(e);if(1!==r.size)return e;var n=r.first();return t.transforms.get(n).transformer.definition.isDecorator?this.getDecorator(n):e},e.prototype.get=function(e,t){void 0===t&&(t=!1);var r=this.root.get(e);if(r)return t?this.plugin.state.data.cells.get(r.ref):this.plugin.state.data.cells.get(this.getDecorator(r.ref))},e.prototype.addMapping=function(e,t,r){if(!v.a.Molecule.Structure.is(r))return!1;if(this.tracked.set(t,r.data),this.root.has(r.data)){this.root.get(r.data).count++}else{var n=e.select(g.StateSelection.Generators.byRef(t).rootOfType([v.a.Molecule.Structure]))[0];n?this.root.set(r.data,{ref:n.transform.ref,count:1}):this.root.set(r.data,{ref:t,count:1})}return!0},e.prototype.removeMapping=function(e){if(!this.tracked.has(e))return!1;var t=this.tracked.get(e);this.tracked.delete(e);var r=this.root.get(t);return r.count>1?r.count--:this.root.delete(t),!0},e.prototype.updateMapping=function(e,t,r,n){return!!v.a.Molecule.Structure.is(n)&&(this.removeMapping(t),this.addMapping(e,t,n),!0)},e.prototype.dispose=function(){this.ev.dispose()},e}(),_c=r(75),Sc=r(297),xc=function(){function e(){this.ev=lc.RxEventHelper.create(),this.id=0,this.runningTasks=new Set,this.abortRequests=new Map,this.options=new Map,this.currentContext=[],this.events={progress:this.ev(),finished:this.ev()}}return e.prototype.tryGetAbortTaskId=function(e){if(this.abortRequests.has(e.progress.taskId))return e.progress.taskId;for(var t=0,r=e.children;t<r.length;t++){var n=r[t],i=this.tryGetAbortTaskId(n);if(void 0!==i)return i}},e.prototype.track=function(e,t){var r=this;return function(n){var i;if(n.canAbort&&n.requestAbort){var a=r.tryGetAbortTaskId(n.root);void 0!==a&&n.requestAbort(r.abortRequests.get(a))}var o=Object(_c.b)()-n.root.progress.startedTime;r.events.progress.next({id:e,useOverlay:null===(i=r.options.get(t))||void 0===i?void 0:i.useOverlay,level:o<250?"none":"background",progress:n})}},e.prototype.run=function(e,t){return Object(o.__awaiter)(this,void 0,void 0,(function(){var r,n;return Object(o.__generator)(this,(function(i){switch(i.label){case 0:r=this.id++,(null==t?void 0:t.createNewContext)||0===this.currentContext.length?n={ctx:Object(Sc.a)(e,this.track(r,e.id),100),refCount:1}:(n=this.currentContext[this.currentContext.length-1]).refCount++,i.label=1;case 1:return i.trys.push([1,,3,4]),this.options.set(e.id,{useOverlay:!!(null==t?void 0:t.useOverlay)}),this.runningTasks.add(e.id),[4,Object(Sc.b)(n.ctx,e)];case 2:return[2,i.sent()];case 3:return this.options.delete(e.id),this.runningTasks.delete(e.id),this.events.finished.next({id:r}),this.abortRequests.delete(e.id),n.refCount--,0===n.refCount&&Object(j.arrayRemoveInPlace)(this.currentContext,n),[7];case 4:return[2]}}))}))},e.prototype.requestAbortAll=function(e){var t=this;this.runningTasks.forEach((function(r){return t.abortRequests.set(r,e)}))},e.prototype.requestAbort=function(e,t){var r="number"==typeof e?e:e.root.progress.taskId;this.abortRequests.set(r,t)},e.prototype.dispose=function(){this.ev.dispose()},e}();(xc||(xc={})).testTask=function(e){var t=this;return _.b.create("Test",(function(r){return Object(o.__awaiter)(t,void 0,void 0,(function(){var t;return Object(o.__generator)(this,(function(n){switch(n.label){case 0:t=0,n.label=1;case 1:return t<e?[4,(i=100+200*Math.random(),new Promise((function(e){return setTimeout(e,i)})))]:[3,5];case 2:return n.sent(),r.shouldUpdate?[4,r.update({message:"Step "+t,current:t,max:e,isIndeterminate:!1})]:[3,4];case 3:n.sent(),n.label=4;case 4:return t++,[3,1];case 5:return[2]}var i}))}))}))};var Oc=function(e){function t(t){var r=e.call(this,{entries:Object(u.OrderedMap)()})||this;return r.events={changed:r.ev()},r.serialNumber=0,r.serialId=0,mc.PluginCommands.Toast.Show.subscribe(t,(function(e){return r.show(e)})),mc.PluginCommands.Toast.Hide.subscribe(t,(function(e){return r.hide(r.findByKey(e.key))})),r}return Object(o.__extends)(t,e),t.prototype.findByKey=function(e){return this.state.entries.find((function(t){return!!t&&t.key===e}))},t.prototype.show=function(e){var t,r=this,n=this.state.entries,i=void 0,a=++this.serialId;e.key&&(i=this.findByKey(e.key))?(void 0!==i.timeout&&clearTimeout(i.timeout),t=i.serialNumber,n=n.remove(i.id)):t=++this.serialNumber,i={id:a,serialNumber:t,key:e.key,title:e.title,message:e.message,timeout:this.timeout(a,e.timeoutMs),hide:function(){return r.hideId(a)}},this.updateState({entries:n.set(a,i)})&&this.events.changed.next()},t.prototype.timeout=function(e,t){var r=this;if(void 0!==t)return t<0&&(t=500),setTimeout((function(){var t=r.state.entries.get(e);t.timeout=void 0,r.hide(t)}),t)},t.prototype.hideId=function(e){this.hide(this.state.entries.get(e))},t.prototype.hide=function(e){e&&(void 0!==e.timeout&&clearTimeout(e.timeout),e.hide=void 0,this.updateState({entries:this.state.entries.delete(e.id)})&&this.events.changed.next())},t}(Oe.b),wc=r(242);function Cc(e,t,r){void 0===r&&(r=1);var n=window.innerWidth,i=window.innerHeight;t!==document.body&&(n=t.offsetWidth,i=t.offsetHeight),function(e,t,r,n){void 0===n&&(n=1),e.width=Math.round(window.devicePixelRatio*n*t),e.height=Math.round(window.devicePixelRatio*n*r),Object.assign(e.style,{width:t+"px",height:r+"px"})}(e,n,i,r)}function jc(e,t,r){return Object(o.__awaiter)(this,void 0,void 0,(function(){return Object(o.__generator)(this,(function(n){return[2,new Promise((function(n,i){var a=function(e){e?n(e):i("no blob returned")};HTMLCanvasElement.prototype.toBlob?e.toBlob(a,t,r):function(e,t,r,n){for(var i=atob(e.toDataURL(r,n).split(",")[1]),a=i.length,o=a>>2,s=new Uint8Array(a),u=new Uint32Array(s.buffer,0,o),c=0,l=0;l<o;++l)u[l]=i.charCodeAt(c++)|i.charCodeAt(c++)<<8|i.charCodeAt(c++)<<16|i.charCodeAt(c++)<<24;for(var d=3&a;d--;)s[c]=i.charCodeAt(c++);t(new Blob([s],{type:r||"image/png"}))}(e,a,t,r)}))]}))}))}var Pc=r(373),Ec=r(96),Ac=function(e){function t(t){var r=e.call(this)||this;return r.plugin=t,r._params=void 0,r.behaviors={values:r.ev.behavior({transparent:r.params.transparent.defaultValue,axes:{name:"off",params:{}},resolution:r.params.resolution.defaultValue}),cropParams:r.ev.behavior({auto:!0,relativePadding:.1}),relativeCrop:r.ev.behavior({x:0,y:0,width:1,height:1})},r.events={previewed:r.ev()},r.canvas=document.createElement("canvas"),r.previewCanvas=document.createElement("canvas"),r.previewData={image:{data:new Uint8ClampedArray(1),width:1,height:0},background:Object(oc.Color)(0),transparent:!1},r}return Object(o.__extends)(t,e),t.prototype.createParams=function(){var e=Math.min(this.plugin.canvas3d?this.plugin.canvas3d.webgl.maxRenderbufferSize:4096,4096);return{resolution:d.ParamDefinition.MappedStatic("viewport",{viewport:d.ParamDefinition.Group({}),hd:d.ParamDefinition.Group({}),"full-hd":d.ParamDefinition.Group({}),"ultra-hd":d.ParamDefinition.Group({}),custom:d.ParamDefinition.Group({width:d.ParamDefinition.Numeric(1920,{min:128,max:e,step:1}),height:d.ParamDefinition.Numeric(1080,{min:128,max:e,step:1})},{isFlat:!0})},{options:[["viewport","Viewport"],["hd","HD (1280 x 720)"],["full-hd","Full HD (1920 x 1080)"],["ultra-hd","Ultra HD (3840 x 2160)"],["custom","Custom"]]}),transparent:d.ParamDefinition.Boolean(!1),axes:wc.b.axes}},Object.defineProperty(t.prototype,"params",{get:function(){return this._params?this._params:this._params=this.createParams()},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"values",{get:function(){return this.behaviors.values.value},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"cropParams",{get:function(){return this.behaviors.cropParams.value},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"relativeCrop",{get:function(){return this.behaviors.relativeCrop.value},enumerable:!1,configurable:!0}),t.prototype.getCanvasSize=function(){var e,t;return{width:(null===(e=this.plugin.canvas3d)||void 0===e?void 0:e.webgl.gl.drawingBufferWidth)||0,height:(null===(t=this.plugin.canvas3d)||void 0===t?void 0:t.webgl.gl.drawingBufferHeight)||0}},t.prototype.getSize=function(){var e=this.values;switch(e.resolution.name){case"viewport":return this.getCanvasSize();case"hd":return{width:1280,height:720};case"full-hd":return{width:1920,height:1080};case"ultra-hd":return{width:3840,height:2160};default:return{width:e.resolution.params.width,height:e.resolution.params.height}}},t.prototype.createPass=function(e){var t=this.plugin.canvas3d,r=t.webgl.extensions,n=r.colorBufferFloat,i=r.textureFloat;return this.plugin.canvas3d.getImagePass({transparentBackground:this.values.transparent,cameraHelper:{axes:this.values.axes},multiSample:{mode:e?"on":"off",sampleLevel:n&&i?4:2},postprocessing:Object(o.__assign)(Object(o.__assign)({},t.props.postprocessing),{antialiasing:{name:"off",params:{}}})})},Object.defineProperty(t.prototype,"previewPass",{get:function(){return this._previewPass||(this._previewPass=this.createPass(!1))},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"imagePass",{get:function(){return this._imagePass?(this._imagePass.setProps({cameraHelper:{axes:this.values.axes},transparentBackground:this.values.transparent,postprocessing:Object(o.__assign)(Object(o.__assign)({},this.plugin.canvas3d.props.postprocessing),{antialiasing:{name:"off",params:{}}})}),this._imagePass):this._imagePass=this.createPass(!0)},enumerable:!1,configurable:!0}),t.prototype.getFilename=function(e){void 0===e&&(e=".png");var t=this.plugin.state.data.select(g.StateSelection.Generators.rootsOfType(v.a.Molecule.Model)).map((function(e){return e.obj.data})),r=new Set;return t.forEach((function(e){return r.add(e.entryId.toUpperCase())})),""+(Ec.a.toArray(r).join("-")||"molstar-image")+e},t.prototype.resetCrop=function(){this.behaviors.relativeCrop.next({x:0,y:0,width:1,height:1})},t.prototype.toggleAutocrop=function(){this.cropParams.auto?(this.behaviors.cropParams.next(Object(o.__assign)(Object(o.__assign)({},this.cropParams),{auto:!1})),this.resetCrop()):this.behaviors.cropParams.next(Object(o.__assign)(Object(o.__assign)({},this.cropParams),{auto:!0}))},Object.defineProperty(t.prototype,"isFullFrame",{get:function(){var e=this.relativeCrop;return Object(Ao.b)(e.x,0,1e-5)&&Object(Ao.b)(e.y,0,1e-5)&&Object(Ao.b)(e.width,1,1e-5)&&Object(Ao.b)(e.height,1,1e-5)},enumerable:!1,configurable:!0}),t.prototype.autocrop=function(e){void 0===e&&(e=this.cropParams.relativePadding);for(var t=this.previewData.image,r=t.data,n=t.width,i=t.height,a=this.previewData.transparent,o=a?this.previewData.background:4278190080|this.previewData.background,s=n,u=0,c=i,l=0,d=0;d<i;d++)for(var f=d*n,p=0;p<n;p++){var m=4*(f+p);if(a){if(0===r[m+3])continue}else if((r[m]<<16|r[m+1]<<8|r[m+2]|r[m+3]<<24)===o)continue;p<s&&(s=p),p>u&&(u=p),d<c&&(c=d),d>l&&(l=d)}if(s>u){var h=s;s=u,u=h}if(c>l){h=c;c=l,l=h}var g=u-s+1,v=l-c+1;s-=e*g,u+=e*g,c-=e*v,l+=e*v;var b={x:Math.max(0,s/n),y:Math.max(0,c/i),width:Math.min(1,(u-s+1)/n),height:Math.min(1,(l-c+1)/i)};this.behaviors.relativeCrop.next(b)},t.prototype.getPreview=function(e){void 0===e&&(e=320);var t=this.getSize(),r=t.width,n=t.height;if(!(r<=0||n<=0)){var i=r/n,a=0,o=0;i>1?(a=e,o=Math.round(e/i)):(o=e,a=Math.round(e*i));var s=this.plugin.canvas3d.props;this.previewPass.setProps({cameraHelper:{axes:this.values.axes},transparentBackground:this.values.transparent,postprocessing:s.postprocessing});var u=this.previewPass.getImageData(a,o),c=this.previewCanvas;c.width=u.width,c.height=u.height,this.previewData.image=u,this.previewData.background=s.renderer.backgroundColor,this.previewData.transparent=this.values.transparent;var l=c.getContext("2d");if(!l)throw new Error("Could not create canvas 2d context");return l.putImageData(u,0,0),this.cropParams.auto&&this.autocrop(),this.events.previewed.next(),{canvas:c,width:a,height:o}}},t.prototype.getSizeAndViewport=function(){var e=this.getSize(),t=e.width,r=e.height,n=this.relativeCrop,i={x:Math.floor(n.x*t),y:Math.floor(n.y*r),width:Math.ceil(n.width*t),height:Math.ceil(n.height*r)};return i.width+i.x>t&&(i.width=t-i.x),i.height+i.y>r&&(i.height=r-i.y),{width:t,height:r,viewport:i}},t.prototype.draw=function(e){return Object(o.__awaiter)(this,void 0,void 0,(function(){var t,r,n,i,a,s,u;return Object(o.__generator)(this,(function(o){switch(o.label){case 0:return t=this.getSizeAndViewport(),r=t.width,n=t.height,i=t.viewport,r<=0||n<=0?[2]:[4,e.update("Rendering image...")];case 1:return o.sent(),a=this.imagePass.getImageData(r,n,i),[4,e.update("Encoding image...")];case 2:if(o.sent(),(s=this.canvas).width=a.width,s.height=a.height,!(u=s.getContext("2d")))throw new Error("Could not create canvas 2d context");return u.putImageData(a,0,0),[2]}}))}))},t.prototype.copyToClipboardTask=function(){var e=this,t=navigator.clipboard;if(null==t?void 0:t.write)return _.b.create("Copy Image",(function(r){return Object(o.__awaiter)(e,void 0,void 0,(function(){var e,n;return Object(o.__generator)(this,(function(i){switch(i.label){case 0:return[4,this.draw(r)];case 1:return i.sent(),[4,r.update("Converting image...")];case 2:return i.sent(),[4,jc(this.canvas,"png")];case 3:return e=i.sent(),n=new ClipboardItem({"image/png":e}),t.write([n]),this.plugin.log.message("Image copied to clipboard."),[2]}}))}))}));this.plugin.log.error("clipboard.write not supported!")},t.prototype.getImageDataUri=function(){var e=this;return this.plugin.runTask(_.b.create("Generate Image",(function(t){return Object(o.__awaiter)(e,void 0,void 0,(function(){return Object(o.__generator)(this,(function(e){switch(e.label){case 0:return[4,this.draw(t)];case 1:return e.sent(),[4,t.update("Converting image...")];case 2:return e.sent(),[2,this.canvas.toDataURL("png")]}}))}))})))},t.prototype.copyToClipboard=function(){var e=this.copyToClipboardTask();if(e)return this.plugin.runTask(e)},t.prototype.downloadTask=function(e){var t=this;return _.b.create("Download Image",(function(r){return Object(o.__awaiter)(t,void 0,void 0,(function(){var t;return Object(o.__generator)(this,(function(n){switch(n.label){case 0:return[4,this.draw(r)];case 1:return n.sent(),[4,r.update("Downloading image...")];case 2:return n.sent(),[4,jc(this.canvas,"png")];case 3:return t=n.sent(),Object(Pc.a)(t,null!=e?e:this.getFilename()),[2]}}))}))}))},t.prototype.download=function(e){this.plugin.runTask(this.downloadTask(e))},t}(Oe.a),Dc=r(323),Tc=r(119),Ic=r(372),Mc=function(e){function t(t){var r=e.call(this,{params:{current:""},animationState:"stopped"})||this;return r.context=t,r.map=new Map,r._animations=[],r.currentTime=0,r._params=void 0,r.events={updated:r.ev(),applied:r.ev()},r.isStopped=!0,r.isApplying=!1,r}return Object(o.__extends)(t,e),Object.defineProperty(t.prototype,"isEmpty",{get:function(){return 0===this._animations.length},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"current",{get:function(){return this._current},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"animations",{get:function(){return this._animations},enumerable:!1,configurable:!0}),t.prototype.triggerUpdate=function(){this.events.updated.next()},t.prototype.triggerApply=function(){this.events.applied.next()},t.prototype.getParams=function(){return this._params||(this._params={current:d.ParamDefinition.Select(this._animations[0]&&this._animations[0].name,this._animations.map((function(e){return[e.name,e.display.name]})),{label:"Animation"})}),this._params},t.prototype.updateParams=function(e){if(!this.isEmpty){this.updateState({params:Object(o.__assign)(Object(o.__assign)({},this.state.params),e)});var t=this.map.get(this.state.params.current),r=t.params(this.context);this._current={anim:t,params:r,paramValues:d.ParamDefinition.getDefaultValues(r),state:{},startedTime:-1,lastTime:0},this.triggerUpdate()}},t.prototype.updateCurrentParams=function(e){this.isEmpty||(this._current.paramValues=Object(o.__assign)(Object(o.__assign)({},this._current.paramValues),e),this.triggerUpdate())},t.prototype.register=function(e){this.map.has(e.name)?this.context.log.error("Animation '"+e.name+"' is already registered."):(this._params=void 0,this.map.set(e.name,e),this._animations.push(e),1===this._animations.length?this.updateParams({current:e.name}):this.triggerUpdate())},t.prototype.play=function(e,t){return Object(o.__awaiter)(this,void 0,void 0,(function(){return Object(o.__generator)(this,(function(r){switch(r.label){case 0:return[4,this.stop()];case 1:return r.sent(),this.map.has(e.name)||this.register(e),this.updateParams({current:e.name}),this.updateCurrentParams(t),[4,this.start()];case 2:return r.sent(),[2]}}))}))},t.prototype.tick=function(e,t){return Object(o.__awaiter)(this,void 0,void 0,(function(){return Object(o.__generator)(this,(function(r){switch(r.label){case 0:return this.currentTime=e,this.isStopped?[2]:t?[4,this.applyFrame()]:[3,2];case 1:return r.sent(),[3,3];case 2:this.applyAsync(),r.label=3;case 3:return[2]}}))}))},t.prototype.start=function(){return Object(o.__awaiter)(this,void 0,void 0,(function(){var e,t,r;return Object(o.__generator)(this,(function(n){switch(n.label){case 0:return this.updateState({animationState:"playing"}),this.context.behaviors.state.isAnimating.value||this.context.behaviors.state.isAnimating.next(!0),this.triggerUpdate(),e=this._current.anim,t=this._current.anim.initialState(this._current.paramValues,this.context),e.setup?[4,e.setup(this._current.paramValues,t,this.context)]:[3,2];case 1:(r=n.sent())&&(t=r),n.label=2;case 2:return this._current.lastTime=0,this._current.startedTime=-1,this._current.state=t,this.isStopped=!1,[2]}}))}))},t.prototype.stop=function(){return Object(o.__awaiter)(this,void 0,void 0,(function(){var e;return Object(o.__generator)(this,(function(t){switch(t.label){case 0:return this.isStopped=!0,"stopped"===this.state.animationState?[3,3]:(e=this._current.anim).teardown?[4,e.teardown(this._current.paramValues,this._current.state,this.context)]:[3,2];case 1:t.sent(),t.label=2;case 2:this.updateState({animationState:"stopped"}),this.triggerUpdate(),t.label=3;case 3:return this.context.behaviors.state.isAnimating.value&&this.context.behaviors.state.isAnimating.next(!1),[2]}}))}))},Object.defineProperty(t.prototype,"isAnimating",{get:function(){return"playing"===this.state.animationState},enumerable:!1,configurable:!0}),t.prototype.applyAsync=function(){return Object(o.__awaiter)(this,void 0,void 0,(function(){return Object(o.__generator)(this,(function(e){switch(e.label){case 0:if(this.isApplying)return[2];this.isApplying=!0,e.label=1;case 1:return e.trys.push([1,,3,4]),[4,this.applyFrame()];case 2:return e.sent(),[3,4];case 3:return this.isApplying=!1,[7];case 4:return[2]}}))}))},t.prototype.applyFrame=function(){return Object(o.__awaiter)(this,void 0,void 0,(function(){var e,t;return Object(o.__generator)(this,(function(r){switch(r.label){case 0:return e=this.currentTime,this._current.startedTime<0&&(this._current.startedTime=e),[4,this._current.anim.apply(this._current.state,{lastApplied:this._current.lastTime,current:e-this._current.startedTime},{params:this._current.paramValues,plugin:this.context})];case 1:return"finished"===(t=r.sent()).kind?this.stop():"next"===t.kind&&(this._current.state=t.state,this._current.lastTime=e-this._current.startedTime),this.triggerApply(),[2]}}))}))},t.prototype.getSnapshot=function(){return this.current?{state:this.state,current:{paramValues:this._current.paramValues,state:this._current.anim.stateSerialization?this._current.anim.stateSerialization.toJSON(this._current.state):this._current.state}}:{state:this.state}},t.prototype.setSnapshot=function(e){this.isEmpty||(this.updateState({animationState:e.state.animationState}),this.updateParams(e.state.params),e.current&&(this.current.paramValues=e.current.paramValues,this.current.state=this._current.anim.stateSerialization?this._current.anim.stateSerialization.fromJSON(e.current.state):e.current.state,this.triggerUpdate(),"playing"===this.state.animationState&&this.resume()))},t.prototype.resume=function(){return Object(o.__awaiter)(this,void 0,void 0,(function(){var e;return Object(o.__generator)(this,(function(t){switch(t.label){case 0:return this._current.lastTime=0,this._current.startedTime=-1,e=this._current.anim,this.context.behaviors.state.isAnimating.value||this.context.behaviors.state.isAnimating.next(!0),e.setup?[4,e.setup(this._current.paramValues,this._current.state,this.context)]:[3,2];case 1:t.sent(),t.label=2;case 2:return this.isStopped=!1,[2]}}))}))},t}(Oe.b),kc=r(392),Bc=r(168),Vc=r(301),Rc=function(){function e(e){var t=this;this.plugin=e,this.currentFrame=void 0,this._isAnimating=!1,this.frame=function(){t.tick(Object(_c.b)()),t._isAnimating&&(t.currentFrame=requestAnimationFrame(t.frame))}}return Object.defineProperty(e.prototype,"isAnimating",{get:function(){return this._isAnimating},enumerable:!1,configurable:!0}),e.prototype.tick=function(e,t){var r;return Object(o.__awaiter)(this,void 0,void 0,(function(){return Object(o.__generator)(this,(function(n){switch(n.label){case 0:return[4,this.plugin.managers.animation.tick(e,null==t?void 0:t.isSynchronous)];case 1:return n.sent(),null===(r=this.plugin.canvas3d)||void 0===r||r.tick(e,t),[2]}}))}))},e.prototype.resetTime=function(e){var t;void 0===e&&(e=Object(_c.b)()),null===(t=this.plugin.canvas3d)||void 0===t||t.resetTime(e)},e.prototype.start=function(){this._isAnimating=!0,this.resetTime(),this.currentFrame=requestAnimationFrame(this.frame)},e.prototype.stop=function(){this._isAnimating=!1,void 0!==this.currentFrame&&(cancelAnimationFrame(this.currentFrame),this.currentFrame=void 0)},e}(),Lc=function(){function e(e){var t=this;this.spec=e,this.runTask=function(e,r){return t.managers.task.run(e,r)},this.resolveTask=function(e){if(e)return _.b.is(e)?t.runTask(e):e},this.subs=[],this.disposed=!1,this.ev=lc.RxEventHelper.create(),this.config=new P.PluginConfigManager(this.spec.config),this.state=new bc.a(this),this.commands=new pc.b,this.canvas3dInit=this.ev.behavior(!1),this.behaviors={state:{isAnimating:this.ev.behavior(!1),isUpdating:this.ev.behavior(!1),isBusy:this.ev.behavior(!1)},interaction:{hover:this.ev.behavior({current:ye.a.Loci.Empty,modifiers:uc.b.None,buttons:0,button:0}),click:this.ev.behavior({current:ye.a.Loci.Empty,modifiers:uc.b.None,buttons:0,button:0}),drag:this.ev.behavior({current:ye.a.Loci.Empty,modifiers:uc.b.None,buttons:0,button:0,pageStart:Object(M.Vec2)(),pageEnd:Object(M.Vec2)()}),selectionMode:this.ev.behavior(!1)},labels:{highlight:this.ev.behavior({labels:[]})},layout:{leftPanelTabName:this.ev.behavior("root")},canvas3d:{initialized:this.canvas3dInit.pipe(Object(Bc.a)((function(e){return!!e})),Object(Vc.a)(1))}},this.animationLoop=new Rc(this),this.layout=new vc(this),this.representation={structure:{registry:new rc,themes:{colorThemeRegistry:ic.a.createRegistry(),sizeThemeRegistry:ac.a.createRegistry()}},volume:{registry:new nc.a,themes:{colorThemeRegistry:ic.a.createRegistry(),sizeThemeRegistry:ac.a.createRegistry()}}},this.query={structure:{registry:new pe.d}},this.dataFormats=new fe,this.builders={data:new h(this),structure:void 0},this.helpers={substructureParent:new yc(this),viewportScreenshot:void 0},this.managers={structure:{hierarchy:new je.StructureHierarchyManager(this),component:new xe.StructureComponentManager(this),measurement:new Pe.a(this),selection:new Ie(this),focus:new Ce(this)},volume:{hierarchy:new kc.a(this)},interactivity:void 0,camera:new ve(this),animation:new Mc(this),snapshot:new Ic.a(this),lociLabels:void 0,toast:new Oc(this),asset:new Tc.AssetManager,task:new xc},this.events={log:this.ev(),task:this.managers.task.events,canvas3d:{settingsUpdated:this.ev()}},this.customModelProperties=new n.Registry,this.customStructureProperties=new n.Registry,this.customParamEditors=new Map,this.customStructureControls=new Map,this.genericRepresentationControls=new Map,this.customState=Object.create(null),this.log={entries:Object(u.List)(),entry:function(e){return t.events.log.next(e)},error:function(e){return t.events.log.next(cc.a.error(e))},message:function(e){return t.events.log.next(cc.a.message(e))},info:function(e){return t.events.log.next(cc.a.info(e))},warn:function(e){return t.events.log.next(cc.a.warning(e))}},this.fetch=sc.a,Object(s.c)(!1)}return e.prototype.build=function(){return this.state.data.build()},e.prototype.initViewer=function(e,t){var r,n,i,a,o,u,c,d=this;try{this.layout.setRoot(t),this.spec.layout&&this.spec.layout.initial&&this.layout.setProps(this.spec.layout.initial);var f=!(null!==(r=this.config.get(P.PluginConfig.General.DisableAntialiasing))&&void 0!==r&&r),p=!(null!==(n=this.config.get(P.PluginConfig.General.DisablePreserveDrawingBuffer))&&void 0!==n&&n),m=this.config.get(P.PluginConfig.General.PixelScale)||1,h=this.config.get(P.PluginConfig.General.PickScale)||.25,g=this.config.get(P.PluginConfig.General.EnableWboit)||!1;this.canvas3dContext=l.Canvas3DContext.fromCanvas(e,{antialias:f,preserveDrawingBuffer:p,pixelScale:m,pickScale:h,enableWboit:g}),this.canvas3d=l.Canvas3D.create(this.canvas3dContext),this.canvas3dInit.next(!0);var v=null===(a=null===(i=this.spec.components)||void 0===i?void 0:i.viewport)||void 0===a?void 0:a.canvas3d,b=Object(oc.Color)(16579577);return v?(void 0===(null===(u=v.renderer)||void 0===u?void 0:u.backgroundColor)&&(v=Object(s.a)(v,(function(e){e.renderer?e.renderer.backgroundColor=b:e.renderer={backgroundColor:b}}))),null===(c=this.canvas3d)||void 0===c||c.setProps(v)):null===(o=this.canvas3d)||void 0===o||o.setProps({renderer:{backgroundColor:b}}),this.animationLoop.start(),this.helpers.viewportScreenshot=new Ac(this),this.subs.push(this.canvas3d.interaction.click.subscribe((function(e){return d.behaviors.interaction.click.next(e)}))),this.subs.push(this.canvas3d.interaction.drag.subscribe((function(e){return d.behaviors.interaction.drag.next(e)}))),this.subs.push(this.canvas3d.interaction.hover.subscribe((function(e){return d.behaviors.interaction.hover.next(e)}))),this.subs.push(this.canvas3d.input.resize.subscribe((function(){return d.handleResize()}))),this.subs.push(this.layout.events.updated.subscribe((function(){return requestAnimationFrame((function(){return d.handleResize()}))}))),this.handleResize(),!0}catch(e){return this.log.error(""+e),console.error(e),!1}},e.prototype.handleResize=function(){var e,t,r=null===(e=this.canvas3dContext)||void 0===e?void 0:e.canvas,n=this.layout.root;n&&r&&(Cc(r,n,this.config.get(P.PluginConfig.General.PixelScale)||1),null===(t=this.canvas3d)||void 0===t||t.requestResize())},Object.defineProperty(e.prototype,"isBusy",{get:function(){return this.behaviors.state.isAnimating.value||this.behaviors.state.isUpdating.value},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"selectionMode",{get:function(){return this.behaviors.interaction.selectionMode.value},set:function(e){this.behaviors.interaction.selectionMode.next(e)},enumerable:!1,configurable:!0}),e.prototype.dataTransaction=function(e,t){return this.runTask(this.state.data.transaction(e,t))},e.prototype.clear=function(e){var t;return void 0===e&&(e=!1),e&&(null===(t=this.canvas3d)||void 0===t||t.setProps(l.DefaultCanvas3DParams)),mc.PluginCommands.State.RemoveObject(this,{state:this.state.data,ref:g.StateTransform.RootRef})},e.prototype.dispose=function(e){var t,r;if(!this.disposed){for(var n=0,i=this.subs;n<i.length;n++){i[n].unsubscribe()}this.subs=[],this.commands.dispose(),null===(t=this.canvas3d)||void 0===t||t.dispose(),null===(r=this.canvas3dContext)||void 0===r||r.dispose(e),this.ev.dispose(),this.state.dispose(),this.managers.task.dispose(),this.layout.dispose(),this.helpers.substructureParent.dispose(),Object(x.c)(this.managers,(function(e){var t,r;return null===(r=null===(t=e)||void 0===t?void 0:t.dispose)||void 0===r?void 0:r.call(t)})),Object(x.c)(this.managers.structure,(function(e){var t,r;return null===(r=null===(t=e)||void 0===t?void 0:t.dispose)||void 0===r?void 0:r.call(t)})),this.disposed=!0}},e.prototype.initBehaviorEvents=function(){var e=this;this.subs.push(Object(c.a)(this.state.data.behaviors.isUpdating,this.state.behaviors.behaviors.isUpdating).subscribe((function(t){e.behaviors.state.isUpdating.value!==t&&e.behaviors.state.isUpdating.next(t)})));var t=this.config.get(P.PluginConfig.General.IsBusyTimeoutMs)||750,r=this.behaviors.state.isBusy,n=void 0,i=function(){r.value||r.next(!0)},a=function(){void 0!==n&&clearTimeout(n),n=void 0};this.subs.push(Object(c.a)(this.behaviors.state.isUpdating,this.behaviors.state.isAnimating).subscribe((function(o){var s=e.behaviors.state.isUpdating.value,u=e.behaviors.state.isAnimating.value;s||u?r.value||(a(),n=setTimeout(i,t)):(a(),r.next(!1))}))),this.subs.push(this.behaviors.interaction.selectionMode.subscribe((function(t){var r;t||null===(r=e.managers.interactivity)||void 0===r||r.lociSelects.deselectAll()})))},e.prototype.initBuiltInBehavior=function(){var e=this;dc.BuiltInPluginBehaviors.State.registerDefault(this),dc.BuiltInPluginBehaviors.Representation.registerDefault(this),dc.BuiltInPluginBehaviors.Camera.registerDefault(this),dc.BuiltInPluginBehaviors.Misc.registerDefault(this),this.subs.push(Object(c.a)(this.state.data.events.log,this.state.behaviors.events.log).subscribe((function(t){return e.events.log.next(t)})))},e.prototype.initBehaviors=function(){return Object(o.__awaiter)(this,void 0,void 0,(function(){var e,t,r,n,i,a,s,u,c;return Object(o.__generator)(this,(function(o){switch(o.label){case 0:for(e=this.state.behaviors.build(),t=0,r=Object.keys(fc.a.Categories);t<r.length;t++)c=r[t],e.toRoot().apply(fc.a.CreateCategory,{label:fc.a.Categories[c]},{ref:c,state:{isLocked:!0}});for(n=0,i=this.spec.behaviors;n<i.length;n++)u=i[n],"custom-props"===(c=fc.a.getCategoryId(u.transformer))&&e.to(fc.a.getCategoryId(u.transformer)).apply(u.transformer,u.defaultParams,{ref:u.transformer.id});return[4,this.runTask(this.state.behaviors.updateTree(e,{doNotUpdateCurrent:!0,doNotLogTiming:!0}))];case 1:for(o.sent(),e=this.state.behaviors.build(),a=0,s=this.spec.behaviors;a<s.length;a++)u=s[a],"custom-props"!==(c=fc.a.getCategoryId(u.transformer))&&e.to(fc.a.getCategoryId(u.transformer)).apply(u.transformer,u.defaultParams,{ref:u.transformer.id});return[4,this.runTask(this.state.behaviors.updateTree(e,{doNotUpdateCurrent:!0,doNotLogTiming:!0}))];case 2:return o.sent(),[2]}}))}))},e.prototype.initCustomFormats=function(){if(this.spec.customFormats)for(var e=0,t=this.spec.customFormats;e<t.length;e++){var r=t[e];this.dataFormats.add(r[0],r[1])}},e.prototype.initDataActions=function(){for(var e=0,t=this.spec.actions;e<t.length;e++){var r=t[e];this.state.data.actions.add(r.action)}},e.prototype.initAnimations=function(){if(this.spec.animations)for(var e=0,t=this.spec.animations;e<t.length;e++){var r=t[e];this.managers.animation.register(r)}},e.prototype.initCustomParamEditors=function(){if(this.spec.customParamEditors)for(var e=0,t=this.spec.customParamEditors;e<t.length;e++){var r=t[e],n=r[0],i=r[1];this.customParamEditors.set(n.id,i)}},e.prototype.init=function(){return Object(o.__awaiter)(this,void 0,void 0,(function(){var e=this;return Object(o.__generator)(this,(function(t){switch(t.label){case 0:return this.subs.push(this.events.log.subscribe((function(t){return e.log.entries=e.log.entries.push(t)}))),this.initCustomFormats(),this.initBehaviorEvents(),this.initBuiltInBehavior(),this.managers.interactivity=new be.a(this),this.managers.lociLabels=new Se(this),this.builders.structure=new Q(this),this.initDataActions(),this.initAnimations(),this.initCustomParamEditors(),[4,this.initBehaviors()];case 1:return t.sent(),this.log.message("Mol* Plugin "+Dc.a+" ["+Dc.b.toLocaleString()+"]"),S.b||this.log.message("Development mode enabled"),S.a&&this.log.message("Debug mode enabled"),[2]}}))}))},e}()},function(e,t,r){"use strict";r.r(t),r.d(t,"Plugin",(function(){return re})),r.d(t,"PluginContextContainer",(function(){return ne})),r.d(t,"ControlsWrapper",(function(){return ae})),r.d(t,"DefaultViewport",(function(){return oe})),r.d(t,"Log",(function(){return se}));var n=r(0),i=r(3),a=r(5),o=r(33),s=r(278),u=r(146),c=r(27),l=r(13),d=r(18),f=r(73),p=r(399),m=r(292),h=r(386),g=r(195),v=r(15),b=function(e){function t(){var t,r=e.apply(this,arguments)||this;return r.state={tab:r.plugin.behaviors.layout.leftPanelTabName.value},r.set=function(e){if(r.state.tab===e)return r.setState({tab:"none"},(function(){return r.plugin.behaviors.layout.leftPanelTabName.next("none")})),void c.PluginCommands.Layout.Update(r.plugin,{state:{regionState:Object(n.__assign)(Object(n.__assign)({},r.plugin.layout.state.regionState),{left:"collapsed"})}});r.setState({tab:e},(function(){return r.plugin.behaviors.layout.leftPanelTabName.next(e)})),"full"!==r.plugin.layout.state.regionState.left&&c.PluginCommands.Layout.Update(r.plugin,{state:{regionState:Object(n.__assign)(Object(n.__assign)({},r.plugin.layout.state.regionState),{left:"full"})}})},r.tabs={none:i.createElement(i.Fragment,null),root:i.createElement(i.Fragment,null,i.createElement(d.SectionHeader,{icon:v.HomeOutlinedSvg,title:"Home"}),i.createElement(p.StateObjectActions,{state:r.plugin.state.data,nodeRef:l.StateTransform.RootRef,hideHeader:!0,initiallyCollapsed:!0,alwaysExpandFirst:!0}),"none"!==(null===(t=r.plugin.spec.components)||void 0===t?void 0:t.remoteState)&&i.createElement(m.RemoteStateSnapshots,{listOnly:!0})),data:i.createElement(i.Fragment,null,i.createElement(d.SectionHeader,{icon:v.AccountTreeOutlinedSvg,title:i.createElement(i.Fragment,null,i.createElement(S,null)," State Tree")}),i.createElement(h.StateTree,{state:r.plugin.state.data})),states:i.createElement(m.StateSnapshots,null),settings:i.createElement(i.Fragment,null,i.createElement(d.SectionHeader,{icon:v.TuneSvg,title:"Plugin Settings"}),i.createElement(_,null)),help:i.createElement(i.Fragment,null,i.createElement(d.SectionHeader,{icon:v.HelpOutlineSvg,title:"Help"}),i.createElement(g.HelpContent,null))},r}return Object(n.__extends)(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.behaviors.layout.leftPanelTabName,(function(t){e.state.tab!==t&&e.setState({tab:t}),"none"===t&&"collapsed"!==e.plugin.layout.state.regionState.left&&c.PluginCommands.Layout.Update(e.plugin,{state:{regionState:Object(n.__assign)(Object(n.__assign)({},e.plugin.layout.state.regionState),{left:"collapsed"})}})})),this.subscribe(this.plugin.state.data.events.changed,(function(t){var r=t.state;"data"===e.state.tab&&1===r.cells.size&&e.set("root")}))},t.prototype.render=function(){var e=this,t=this.state.tab;return i.createElement("div",{className:"msp-left-panel-controls"},i.createElement("div",{className:"msp-left-panel-controls-buttons"},i.createElement(d.IconButton,{svg:v.HomeOutlinedSvg,toggleState:"root"===t,transparent:!0,onClick:function(){return e.set("root")},title:"Home"}),i.createElement(y,{set:this.set}),i.createElement(d.IconButton,{svg:v.SaveOutlinedSvg,toggleState:"states"===t,transparent:!0,onClick:function(){return e.set("states")},title:"Plugin State"}),i.createElement(d.IconButton,{svg:v.HelpOutlineSvg,toggleState:"help"===t,transparent:!0,onClick:function(){return e.set("help")},title:"Help"}),i.createElement("div",{className:"msp-left-panel-controls-buttons-bottom"},i.createElement(d.IconButton,{svg:v.TuneSvg,toggleState:"settings"===t,transparent:!0,onClick:function(){return e.set("settings")},title:"Settings"}))),i.createElement("div",{className:"msp-scrollable-container"},this.tabs[t]))},t}(o.PluginUIComponent),y=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={changed:!1},t}return Object(n.__extends)(t,e),Object.defineProperty(t.prototype,"tab",{get:function(){return this.plugin.behaviors.layout.leftPanelTabName.value},enumerable:!1,configurable:!0}),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.behaviors.layout.leftPanelTabName,(function(t){"data"===e.tab?e.setState({changed:!1}):e.forceUpdate()})),this.subscribe(this.plugin.state.data.events.changed,(function(t){"data"!==e.tab&&e.setState({changed:!0})}))},t.prototype.render=function(){var e=this;return i.createElement(d.IconButton,{svg:v.AccountTreeOutlinedSvg,toggleState:"data"===this.tab,transparent:!0,onClick:function(){return e.props.set("data")},title:"State Tree",style:{position:"relative"},extraContent:this.state.changed?i.createElement("div",{className:"msp-left-panel-controls-button-data-dirty"}):void 0})},t}(o.PluginUIComponent),_=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.setSettings=function(e){var r;c.PluginCommands.Canvas3D.SetSettings(t.plugin,{settings:(r={},r[e.name]=e.value,r)})},t}return Object(n.__extends)(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.events.canvas3d.settingsUpdated,(function(){return e.forceUpdate()})),this.subscribe(this.plugin.layout.events.updated,(function(){return e.forceUpdate()})),this.subscribe(this.plugin.canvas3d.camera.stateChanged,(function(t){void 0===t.radiusMax&&void 0===t.radius||e.forceUpdate()}))},t.prototype.render=function(){return i.createElement(i.Fragment,null,this.plugin.canvas3d&&i.createElement(i.Fragment,null,i.createElement(d.SectionHeader,{title:"Viewport"}),i.createElement(f.ParameterControls,{params:u.Canvas3DParams,values:this.plugin.canvas3d.props,onChange:this.setSettings})),i.createElement(d.SectionHeader,{title:"Behavior"}),i.createElement(h.StateTree,{state:this.plugin.state.behaviors}))},t}(o.PluginUIComponent),S=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.remove=function(e){e.preventDefault(),c.PluginCommands.State.RemoveObject(t.plugin,{state:t.plugin.state.data,ref:l.StateTransform.RootRef})},t}return Object(n.__extends)(t,e),t.prototype.componentDidMount=function(){var e=this;this.subscribe(this.plugin.state.events.cell.created,(function(t){t.cell.transform.parent===l.StateTransform.RootRef&&e.forceUpdate()})),this.subscribe(this.plugin.state.events.cell.removed,(function(t){t.parent===l.StateTransform.RootRef&&e.forceUpdate()}))},t.prototype.render=function(){return 0===this.plugin.state.data.tree.children.get(l.StateTransform.RootRef).size?null:i.createElement(d.IconButton,{svg:v.DeleteOutlinedSvg,onClick:this.remove,title:"Remove All",style:{display:"inline-block"},small:!0,className:"msp-no-hover-outline",transparent:!0})},t}(o.PluginUIComponent),x=r(8),O=r(90),w=r(4),C=r(62),j=r(400),P=r(6),E=r(41),A=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.parentDiv=i.createRef(),t.lastMouseOverSeqIdx=-1,t.highlightQueue=new C.a,t.lociHighlightProvider=function(e,r){t.props.sequenceWrapper.markResidue(e.loci,r)&&t.updateMarker()},t.lociSelectionProvider=function(e,r){t.props.sequenceWrapper.markResidue(e.loci,r)&&t.updateMarker()},t.contextMenu=function(e){e.preventDefault()},t.mouseDownLoci=void 0,t.mouseDown=function(e){e.stopPropagation();var r=t.getSeqIdx(e),n=t.getLoci(r),i=Object(O.e)(e.nativeEvent),a=Object(O.d)(e.nativeEvent),o=Object(O.f)(e.nativeEvent);t.click(n,i,a,o),t.mouseDownLoci=n},t.mouseUp=function(e){if(e.stopPropagation(),void 0!==t.mouseDownLoci){var r=t.getSeqIdx(e),n=t.getLoci(r);if(n&&!w.StructureElement.Loci.areEqual(t.mouseDownLoci,n)){var i=Object(O.e)(e.nativeEvent),a=Object(O.d)(e.nativeEvent),o=Object(O.f)(e.nativeEvent),s=t.mouseDownLoci.elements[0],u=n.elements[0],c=Math.min(P.OrderedSet.min(s.indices),P.OrderedSet.min(u.indices)),l=Math.max(P.OrderedSet.max(s.indices),P.OrderedSet.max(u.indices)),d=w.StructureElement.Loci(n.structure,[{unit:s.unit,indices:P.OrderedSet.ofRange(c,l)}]);t.click(w.StructureElement.Loci.subtract(d,t.mouseDownLoci),i,a,o)}t.mouseDownLoci=void 0}},t.location=w.StructureElement.Location.create(void 0),t.mouseMove=function(e){e.stopPropagation();var r=Object(O.e)(e.nativeEvent),i=Object(O.d)(e.nativeEvent),a=Object(O.f)(e.nativeEvent),o=e.target;if(!o||!o.getAttribute){if(-1===t.lastMouseOverSeqIdx)return;return t.lastMouseOverSeqIdx=-1,void t.highlightQueue.next({seqIdx:-1,buttons:r,button:i,modifiers:a})}var s=o.hasAttribute("data-seqid")?+o.getAttribute("data-seqid"):-1;if(t.lastMouseOverSeqIdx!==s)if(t.lastMouseOverSeqIdx=s,void 0!==t.mouseDownLoci){var u=t.getLoci(s);t.hover(u,0,0,Object(n.__assign)(Object(n.__assign)({},a),{shift:!0}))}else t.highlightQueue.next({seqIdx:s,buttons:r,button:i,modifiers:a})},t.mouseLeave=function(e){if(e.stopPropagation(),t.mouseDownLoci=void 0,-1!==t.lastMouseOverSeqIdx){t.lastMouseOverSeqIdx=-1;var r=Object(O.e)(e.nativeEvent),n=Object(O.d)(e.nativeEvent),i=Object(O.f)(e.nativeEvent);t.highlightQueue.next({seqIdx:-1,buttons:r,button:n,modifiers:i})}},t}return Object(n.__extends)(t,e),Object.defineProperty(t.prototype,"sequenceNumberPeriod",{get:function(){return void 0!==this.props.sequenceNumberPeriod?this.props.sequenceNumberPeriod:this.props.sequenceWrapper.length>10?10:this.getSequenceNumber(this.props.sequenceWrapper.length-1).length>1?5:1},enumerable:!1,configurable:!0}),t.prototype.componentDidMount=function(){var e=this;this.plugin.managers.interactivity.lociHighlights.addProvider(this.lociHighlightProvider),this.plugin.managers.interactivity.lociSelects.addProvider(this.lociSelectionProvider),this.subscribe(Object(j.a)(15)(this.highlightQueue),(function(t){var r=e.getLoci(t.seqIdx<0?void 0:t.seqIdx);e.hover(r,t.buttons,t.button,t.modifiers)}))},t.prototype.componentWillUnmount=function(){e.prototype.componentWillUnmount.call(this),this.plugin.managers.interactivity.lociHighlights.removeProvider(this.lociHighlightProvider),this.plugin.managers.interactivity.lociSelects.removeProvider(this.lociSelectionProvider)},t.prototype.getLoci=function(e){if(void 0!==e){var t=this.props.sequenceWrapper.getLoci(e);if(!w.StructureElement.Loci.isEmpty(t))return t}},t.prototype.getSeqIdx=function(e){var t=void 0,r=e.target;return r&&r.getAttribute&&(t=r.hasAttribute("data-seqid")?+r.getAttribute("data-seqid"):void 0),t},t.prototype.hover=function(e,t,r,n){var i={current:E.a.Loci.Empty,buttons:t,button:r,modifiers:n};void 0===e||w.StructureElement.Loci.isEmpty(e)||(i.current={loci:e}),this.plugin.behaviors.interaction.hover.next(i)},t.prototype.click=function(e,t,r,n){var i={current:E.a.Loci.Empty,buttons:t,button:r,modifiers:n};void 0===e||w.StructureElement.Loci.isEmpty(e)||(i.current={loci:e}),this.plugin.behaviors.interaction.click.next(i)},t.prototype.getBackgroundColor=function(e){return void 0===e&&console.error("unexpected marker value"),0===e?"":e%2==0?"rgb(51, 255, 25)":"rgb(255, 102, 153)"},t.prototype.getResidueClass=function(e,t){return t.length>1?this.props.sequenceWrapper.residueClass(e)+(0===e?" msp-sequence-residue-long-begin":" msp-sequence-residue-long"):this.props.sequenceWrapper.residueClass(e)},t.prototype.residue=function(e,t,r){return i.createElement("span",{key:e,"data-seqid":e,style:{backgroundColor:this.getBackgroundColor(r)},className:this.getResidueClass(e,t)},"​"+t+"​")},t.prototype.getSequenceNumberClass=function(e,t,r){var n=["msp-sequence-number"];return t.startsWith("-")?r.length>1&&e>0?n.push("msp-sequence-number-long-negative"):n.push("msp-sequence-number-negative"):r.length>1&&e>0&&n.push("msp-sequence-number-long"),n.join(" ")},t.prototype.getSequenceNumber=function(e){var t="",r=this.props.sequenceWrapper.getLoci(e),n=w.StructureElement.Loci.getFirstLocation(r,this.location);if(n)if(w.Unit.isAtomic(n.unit)){var i=w.StructureProperties.residue.auth_seq_id(n),a=w.StructureProperties.residue.pdbx_PDB_ins_code(n);t=""+i+(a||"")}else w.Unit.isCoarse(n.unit)&&(t=""+(e+1));return t},t.prototype.padSeqNum=function(e){return e.length<5?e+new Array(5-e.length+1).join(" "):e},t.prototype.getSequenceNumberSpan=function(e,t){var r=this.getSequenceNumber(e);return i.createElement("span",{key:"marker-"+e,className:this.getSequenceNumberClass(e,r,t)},this.padSeqNum(r))},t.prototype.updateMarker=function(){if(this.parentDiv.current)for(var e=this.parentDiv.current.children,t=this.props.sequenceWrapper.markerArray,r=!this.props.hideSequenceNumbers,n=this.sequenceNumberPeriod,i=0,a=0,o=t.length;a<o;a++){r&&a%n==0&&a<o&&i++;var s=e[i];if(!s)return;i++;var u=this.getBackgroundColor(t[a]);s.style.backgroundColor!==u&&(s.style.backgroundColor=u)}},t.prototype.render=function(){for(var e=this.props.sequenceWrapper,t=[],r=!this.props.hideSequenceNumbers,n=this.sequenceNumberPeriod,a=0,o=e.length;a<o;++a){var s=e.residueLabel(a);r&&a%n==0&&a<o&&(t[t.length]=this.getSequenceNumberSpan(a,s)),t[t.length]=this.residue(a,s,e.markerArray[a])}return this.updateMarker(),i.createElement("div",{className:"msp-sequence-wrapper",onContextMenu:this.contextMenu,onMouseDown:this.mouseDown,onMouseUp:this.mouseUp,onMouseMove:this.mouseMove,onMouseLeave:this.mouseLeave,ref:this.parentDiv},t)},t}(o.PluginUIComponent),D=r(23),T=r(51),I=function(){function e(e,t,r){this.data=e,this.markerArray=t,this.length=r}return e.prototype.markResidue=function(e,t){return Object(D.isEveryLoci)(e)?Object(T.c)(this.markerArray,P.Interval.ofLength(this.length),t):this.mark(e,t)},e}(),M=r(47),k=function(e){function t(t){var r=this,n=w.StructureElement.Location.create(t.structure,t.units[0],t.units[0].elements[0]),i=t.units[0].model.sequence.byEntityKey[w.StructureProperties.entity.key(n)],a=i.sequence.length,o=new Uint8Array(a);(r=e.call(this,t,o,a)||this).unitMap=new Map;for(var s=0,u=t.units;s<u.length;s++){var c=u[s];r.unitMap.set(c.id,c)}r.sequence=i.sequence,r.missing=t.units[0].model.properties.missingResidues,r.modelNum=t.units[0].model.modelNum,r.asymId=w.Unit.isAtomic(t.units[0])?w.StructureProperties.chain.label_asym_id(n):w.StructureProperties.coarse.asym_id(n);for(var l=[],d=0;d<a;++d)r.missing.has(r.modelNum,r.asymId,r.seqId(d))&&l.push(d);return r.observed=P.OrderedSet.subtract(P.Interval.ofBounds(0,a),P.SortedArray.ofSortedArray(l)),r}return Object(n.__extends)(t,e),t.prototype.seqId=function(e){return this.sequence.seqId.value(e)},t.prototype.residueLabel=function(e){return this.sequence.label.value(e)||this.sequence.code.value(e)},t.prototype.residueColor=function(e){return this.missing.has(this.modelNum,this.asymId,this.seqId(e))?M.a.grey:M.a.black},t.prototype.residueClass=function(e){return this.missing.has(this.modelNum,this.asymId,this.seqId(e))?"msp-sequence-missing":"msp-sequence-present"},t.prototype.mark=function(e,t){var r=this,n=!1,i=this.data.structure,a=function(e){return r.sequence.index(e)};if(w.StructureElement.Loci.is(e)){if(!w.Structure.areRootsEquivalent(e.structure,i))return!1;for(var o=0,s=(e=w.StructureElement.Loci.remap(e,i)).elements;o<s.length;o++){var u=s[o];this.unitMap.has(u.unit.id)&&(n=w.Unit.isAtomic(u.unit)?B(u,t,this.markerArray,a)||n:V(u,t,this.markerArray,a)||n)}}else if(w.Structure.isLoci(e)){if(!w.Structure.areRootsEquivalent(e.structure,i))return!1;Object(T.c)(this.markerArray,this.observed,t)&&(n=!0)}return n},t.prototype.getLoci=function(e){var t,r,n,i=(t=this.data.units[0].chainGroupId,r=this.data.units[0].conformation.operator.name,n=this.seqId(e),w.Queries.generators.atoms({unitTest:function(e){return w.StructureProperties.unit.chainGroupId(e.element)===t&&w.StructureProperties.unit.operator_name(e.element)===r},residueTest:function(e){return 0===e.element.unit.kind?w.StructureProperties.residue.label_seq_id(e.element)===n:w.StructureProperties.coarse.seq_id_begin(e.element)<=n&&w.StructureProperties.coarse.seq_id_end(e.element)>=n}}));return w.StructureSelection.toLociWithSourceUnits(w.StructureQuery.run(i,this.data.structure))},t}(I);function B(e,t,r,n){var i=e.unit,a=i.model,o=i.elements,s=a.atomicHierarchy.residueAtomSegments.index,u=a.atomicHierarchy.residues.label_seq_id,c=!1;return P.OrderedSet.forEachSegment(e.indices,(function(e){return s[o[e]]}),(function(e){var i=u.value(e);c=Object(T.d)(r,n(i),t)||c})),c}function V(e,t,r,n){var i=e.unit,a=i.model,o=i.elements,s=w.Unit.isSpheres(e.unit)?a.coarseHierarchy.spheres.seq_id_begin:a.coarseHierarchy.gaussians.seq_id_begin,u=w.Unit.isSpheres(e.unit)?a.coarseHierarchy.spheres.seq_id_end:a.coarseHierarchy.gaussians.seq_id_end,c=!1;return P.OrderedSet.forEach(e.indices,(function(e){for(var i=o[e],a=n(s.value(i)),l=n(u.value(i));a<=l;a++)c=Object(T.d)(r,a,t)||c})),c}var R=r(2),L=function(e){function t(t){for(var r=this,n=[],i=new Map,a=new Map,o=new Map,s=0,u=t.units.length;s<u;++s)for(var c=(b=t.units[s]).model.atomicHierarchy,l=c.residueAtomSegments,d=c.atoms,f=P.Segmentation.transientSegments(l,b.elements);f.hasNext;){var p=f.move().index;i.set(p,n.length),a.set(n.length,p),o.set(n.length,b),n.push(d.label_comp_id.value(l.offsets[p]))}var m=n.length,h=new Uint8Array(m);(r=e.call(this,t,h,m)||this).unitMap=new Map;for(var g=0,v=t.units;g<v.length;g++){var b=v[g];r.unitMap.set(b.id,b)}return r.sequence=n,r.sequenceIndices=i,r.residueIndices=a,r.seqToUnit=o,r}return Object(n.__extends)(t,e),t.prototype.residueLabel=function(e){return this.sequence[e]},t.prototype.residueColor=function(e){return M.a.black},t.prototype.residueClass=function(e){return"msp-sequence-present"},t.prototype.mark=function(e,t){var r=this,n=!1,i=this.data.structure;if(w.StructureElement.Loci.is(e)){if(!w.Structure.areRootsEquivalent(e.structure,i))return!1;e=w.StructureElement.Loci.remap(e,i);for(var a=function(e){var i=o.unitMap.get(e.unit.id);if(i){var a=e.unit.model.atomicHierarchy.residueAtomSegments.index;P.OrderedSet.forEach(e.indices,(function(e){var o=r.sequenceIndices.get(a[i.elements[e]]);void 0!==o&&Object(T.c)(r.markerArray,P.Interval.ofSingleton(o),t)&&(n=!0)}))}},o=this,s=0,u=e.elements;s<u.length;s++){a(u[s])}}else if(w.Structure.isLoci(e)){if(!w.Structure.areRootsEquivalent(e.structure,i))return!1;Object(T.c)(this.markerArray,P.Interval.ofBounds(0,this.length),t)&&(n=!0)}return n},t.prototype.getLoci=function(e){var t=[],r=this.residueIndices.get(e);if(void 0!==r){var n=this.seqToUnit.get(e),i=n.model.atomicHierarchy.residueAtomSegments.offsets,a=P.SortedArray.findPredecessorIndex(n.elements,i[r]),o=P.SortedArray.findPredecessorIndex(n.elements,i[r+1]);t.push({unit:n,indices:P.Interval.ofBounds(a,o)})}return w.StructureElement.Loci(this.data.structure,t)},t}(I),N=function(e){function t(t){for(var r=this,n=0,i=0,a=[],o=w.StructureElement.Location.create(t.structure),s=new Map,u=[],c=0,l=t.units.length;c<l;++c){var d=t.units[c];w.StructureElement.Location.set(o,t.structure,d,d.elements[0]);var f=d.model.sequence.byEntityKey[w.StructureProperties.entity.key(o)];f&&(n+=f.sequence.length),i+=d.elements.length;var p=P.Interval.ofBounds(0,d.elements.length);s.set(d.id,p),u.push({unit:d,indices:p})}n>0&&a.push(n+" residues"),a.push(i+" elements");var m=new Uint8Array(1);return(r=e.call(this,t,m,1)||this).label="Whole Chain ("+a.join(", ")+")",r.unitIndices=s,r.loci=w.StructureElement.Loci(r.data.structure,u),r}return Object(n.__extends)(t,e),t.prototype.residueLabel=function(e){return this.label},t.prototype.residueColor=function(e){return M.a.black},t.prototype.residueClass=function(e){return"msp-sequence-present"},t.prototype.mark=function(e,t){var r=!1,n=this.data.structure;if(w.StructureElement.Loci.is(e)){if(!w.Structure.areRootsEquivalent(e.structure,n))return!1;for(var i=0,a=(e=w.StructureElement.Loci.remap(e,n)).elements;i<a.length;i++){var o=a[i],s=this.unitIndices.get(o.unit.id);s&&P.OrderedSet.isSubset(s,o.indices)&&Object(T.c)(this.markerArray,P.Interval.ofSingleton(0),t)&&(r=!0)}}else if(w.Structure.isLoci(e)){if(!w.Structure.areRootsEquivalent(e.structure,n))return!1;Object(T.c)(this.markerArray,P.Interval.ofSingleton(0),t)&&(r=!0)}return r},t.prototype.getLoci=function(e){return this.loci},t}(I),F=function(e){function t(t){for(var r=this,n=0,i=new Map,a=[],o=0,s=t.units.length;o<s;++o){var u=t.units[o];n+=u.elements.length;var c=P.Interval.ofBounds(0,u.elements.length);i.set(u.id,c),a.push({unit:u,indices:c})}var l=new Uint8Array(n);return(r=e.call(this,t,l,n)||this).unitIndices=i,r}return Object(n.__extends)(t,e),t.prototype.residueLabel=function(e){return"X"},t.prototype.residueColor=function(e){return M.a.black},t.prototype.residueClass=function(e){return"msp-sequence-present"},t.prototype.mark=function(e,t){var r=!1,n=this.data,i=n.structure,a=n.units;if(w.StructureElement.Loci.is(e)){if(!w.Structure.areRootsEquivalent(e.structure,i))return!1;for(var o=0,s=(e=w.StructureElement.Loci.remap(e,i)).elements;o<s.length;o++){var u=s[o];(d=this.unitIndices.get(u.unit.id))&&P.OrderedSet.isSubset(d,u.indices)&&Object(T.c)(this.markerArray,u.indices,t)&&(r=!0)}}else if(w.Structure.isLoci(e)){if(!w.Structure.areRootsEquivalent(e.structure,i))return!1;for(var c=0,l=a.length;c<l;++c){var d=this.unitIndices.get(a[c].id);Object(T.c)(this.markerArray,d,t)&&(r=!0)}}return r},t.prototype.getLoci=function(e){for(var t=this.data.units,r=[],n=0,i=0,a=t.length;i<a;++i){var o=t[i];if(e<n+o.elements.length){r.push({unit:o,indices:P.Interval.ofSingleton(e-n)});break}n+=o.elements.length}return w.StructureElement.Loci(this.data.structure,r)},t}(I),U=r(77),z=r(29);function H(e){var t=w.StructureProperties.unit.pdbx_struct_oper_list_ids(e),r=w.StructureProperties.unit.struct_ncs_oper_id(e),n=w.StructureProperties.unit.hkl(e),i=w.StructureProperties.unit.spgrOp(e);return t.sort().join(",")+"|"+r+"|"+n+"|"+i}function G(e){var t=e.split("|"),r=t[0],n=t[1];return[parseInt(r),n]}function q(e,t){for(var r=e.structure,n=e.modelEntityId,i=e.chainGroupId,a=e.operatorKey,o=w.StructureElement.Location.create(r),s=G(n),u=s[0],c=s[1],l=[],d=0,f=r.units;d<f.length;d++){var p=f[d];w.StructureElement.Location.set(o,r,p,p.elements[0]),r.getModelIndex(p.model)===u&&(w.StructureProperties.entity.id(o)===c&&p.chainGroupId===i&&H(o)===a&&l.push(p))}if(l.length>0){var m={structure:r,units:l},h=void 0;if((p=l[0]).polymerElements.length){var g=w.StructureElement.Location.create(r,p,p.elements[0]),v=p.model.sequence.byEntityKey[w.StructureProperties.entity.key(g)];if(v&&v.sequence.length<=5e3)h=new k(m);else{var b=l.reduce((function(e,t){return e+t.polymerElements.length}),0);h=w.Unit.isAtomic(p)||b>5e3?new N(m):new F(m)}}else if(w.Unit.isAtomic(p)){h=l.reduce((function(e,t){return e+t.residueCount}),0)>5e3?new N(m):new L(m)}else console.warn("should not happen, expecting coarse units to be polymeric"),h=new N(m);return h.markResidue(t.getLoci(r),T.a.Select),h}return"No sequence available"}function W(e,t){void 0===t&&(t=!1);for(var r=[],n=w.StructureElement.Location.create(e),i=new Set,a=0,o=e.units;a<o.length;a++){var s=o[a];w.StructureElement.Location.set(n,e,s,s.elements[0]);var u=w.StructureProperties.entity.id(n),c=e.getModelIndex(s.model),l=c+"|"+u;if(!i.has(l)&&(!t||"polymer"===w.StructureProperties.entity.type(n))){var d=w.StructureProperties.entity.pdbx_description(n).join(", ");e.models.length&&(e.representativeModel?d+=" (Model "+e.models[c].modelNum+")":d.startsWith("Polymer ")&&(d+=" ("+e.models[c].entry+")"));var f=u+": "+d;r.push([l,f]),i.add(l)}}return 0===r.length&&r.push(["","No entities"]),r}function X(e,t){for(var r=[],n=w.StructureElement.Location.create(e),i=new Set,a=G(t),o=a[0],s=a[1],u=0,c=e.units;u<c.length;u++){var l=c[u];if(w.StructureElement.Location.set(n,e,l,l.elements[0]),e.getModelIndex(l.model)===o&&w.StructureProperties.entity.id(n)===s){var d=l.chainGroupId;if(!i.has(d)){var f=Object(U.elementLabel)(n,{granularity:"chain",hidePrefix:!0,htmlStyling:!1});r.push([d,f]),i.add(d)}}}return 0===r.length&&r.push([-1,"No units"]),r}function Y(e,t,r){for(var n=[],i=w.StructureElement.Location.create(e),a=new Set,o=G(t),s=o[0],u=o[1],c=0,l=e.units;c<l.length;c++){var d=l[c];if(w.StructureElement.Location.set(i,e,d,d.elements[0]),e.getModelIndex(d.model)===s&&w.StructureProperties.entity.id(i)===u&&d.chainGroupId===r){var f=H(i);if(!a.has(f)){var p=d.conformation.operator.name;n.push([f,p]),a.add(f)}}}return 0===n.length&&n.push(["","No operators"]),n}function Q(e){for(var t,r=[],n=[],i=0,a=e.select(l.StateSelection.Generators.rootsOfType(x.a.Molecule.Structure));i<a.length;i++){var o=a[i];(null===(t=o.obj)||void 0===t?void 0:t.data)&&(n.push(o.obj.data),r.push([o.transform.ref,o.obj.data.label]))}return 0===r.length&&r.push(["","No structure"]),{options:r,all:n}}var K=R.ParamDefinition.Select("single",[["single","Chain"],["polymers","Polymers"],["all","Everything"]]),Z=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.state={structureOptions:{options:[],all:[]},structure:w.Structure.Empty,structureRef:"",modelEntityId:"",chainGroupId:-1,operatorKey:"",mode:"single"},t.setParamProps=function(e){var r=Object(n.__assign)({},t.state);switch(e.name){case"mode":if(r.mode=e.value,t.state.mode===r.mode)return;if("all"===r.mode||"polymers"===r.mode)break;case"structure":"structure"===e.name&&(r.structureRef=e.value),r.structure=t.getStructure(r.structureRef),r.modelEntityId=W(r.structure)[0][0],r.chainGroupId=X(r.structure,r.modelEntityId)[0][0],r.operatorKey=Y(r.structure,r.modelEntityId,r.chainGroupId)[0][0];break;case"entity":r.modelEntityId=e.value,r.chainGroupId=X(r.structure,r.modelEntityId)[0][0],r.operatorKey=Y(r.structure,r.modelEntityId,r.chainGroupId)[0][0];break;case"chain":r.chainGroupId=e.value,r.operatorKey=Y(r.structure,r.modelEntityId,r.chainGroupId)[0][0];break;case"operator":r.operatorKey=e.value}t.setState(r)},t}return Object(n.__extends)(t,e),t.prototype.componentDidMount=function(){var e=this;this.plugin.state.data.select(l.StateSelection.Generators.rootsOfType(x.a.Molecule.Structure)).length>0&&this.setState(this.getInitialState()),this.subscribe(this.plugin.state.events.object.updated,(function(t){var r=t.ref,n=t.obj;r===e.state.structureRef&&n&&n.type===x.a.Molecule.Structure.type&&n.data!==e.state.structure&&e.sync()})),this.subscribe(this.plugin.state.events.object.created,(function(t){var r=t.obj;r&&r.type===x.a.Molecule.Structure.type&&e.sync()})),this.subscribe(this.plugin.state.events.object.removed,(function(t){var r=t.obj;r&&r.type===x.a.Molecule.Structure.type&&r.data===e.state.structure&&e.sync()}))},t.prototype.sync=function(){var e=Q(this.plugin.state.data);Object(z.arrayEqual)(e.all,this.state.structureOptions.all)||this.setState(this.getInitialState())},t.prototype.getStructure=function(e){var t=this.plugin.state.data.select(e)[0];return e&&t&&t.obj?t.obj.data:w.Structure.Empty},t.prototype.getSequenceWrapper=function(e){return{wrapper:q(this.state,this.plugin.managers.structure.selection),label:R.ParamDefinition.optionLabel(e.chain,this.state.chainGroupId)+" | "+R.ParamDefinition.optionLabel(e.entity,this.state.modelEntityId)}},t.prototype.getSequenceWrappers=function(e){if("single"===this.state.mode)return[this.getSequenceWrapper(e)];for(var t=this.getStructure(this.state.structureRef),r=[],n=0,i=W(t,"polymers"===this.state.mode);n<i.length;n++)for(var a=i[n],o=a[0],s=a[1],u=0,c=X(t,o);u<c.length;u++)for(var l=c[u],d=l[0],f=l[1],p=0,m=Y(t,o,d);p<m.length;p++){var h=m[p][0];r.push({wrapper:q({structure:t,modelEntityId:o,chainGroupId:d,operatorKey:h},this.plugin.managers.structure.selection),label:f+" | "+s})}return r},t.prototype.getInitialState=function(){var e,t=Q(this.plugin.state.data),r=t.options[0][0],n=this.getStructure(r),i=W(n)[0][0],a=X(n,i)[0][0],o=Y(n,i,a)[0][0];return 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e=this.state,t=e.structureOptions,r=e.structure,n=e.modelEntityId,i=e.chainGroupId,a=W(r),o=X(r,n),s=Y(r,n,i);return{structure:R.ParamDefinition.Select(t.options[0][0],t.options,{shortLabel:!0}),entity:R.ParamDefinition.Select(a[0][0],a,{shortLabel:!0}),chain:R.ParamDefinition.Select(o[0][0],o,{shortLabel:!0,twoColumns:!0,label:"Chain"}),operator:R.ParamDefinition.Select(s[0][0],s,{shortLabel:!0,twoColumns:!0}),mode:K}},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"values",{get:function(){return{structure:this.state.structureRef,entity:this.state.modelEntityId,chain:this.state.chainGroupId,operator:this.state.operatorKey,mode:this.state.mode}},enumerable:!1,configurable:!0}),t.prototype.render=function(){if(this.getStructure(this.state.structureRef)===w.Structure.Empty)return i.createElement("div",{className:"msp-sequence"},i.createElement("div",{className:"msp-sequence-select"},i.createElement(v.Icon,{svg:v.HelpOutlineSvg,style:{cursor:"help",position:"absolute",right:0,top:0},title:"Shows a sequence of one or more chains. Use the controls to alter selection."}),i.createElement("span",null,"Sequence"),i.createElement("span",{style:{fontWeight:"normal"}},"No structure available")));var e=this.params,t=this.values,r=this.getSequenceWrappers(e);return i.createElement("div",{className:"msp-sequence"},i.createElement("div",{className:"msp-sequence-select"},i.createElement(v.Icon,{svg:v.HelpOutlineSvg,style:{cursor:"help",position:"absolute",right:0,top:0},title:"This shows a single sequence. Use the controls to show a different sequence."}),i.createElement("span",null,"Sequence of"),i.createElement(f.PureSelectControl,{title:"[Structure] "+R.ParamDefinition.optionLabel(e.structure,t.structure),param:e.structure,name:"structure",value:t.structure,onChange:this.setParamProps}),i.createElement(f.PureSelectControl,{title:"[Mode]",param:K,name:"mode",value:t.mode,onChange:this.setParamProps}),"single"===t.mode&&i.createElement(f.PureSelectControl,{title:"[Entity] "+R.ParamDefinition.optionLabel(e.entity,t.entity),param:e.entity,name:"entity",value:t.entity,onChange:this.setParamProps}),"single"===t.mode&&i.createElement(f.PureSelectControl,{title:"[Chain] "+R.ParamDefinition.optionLabel(e.chain,t.chain),param:e.chain,name:"chain",value:t.chain,onChange:this.setParamProps}),e.operator.options.length>1&&i.createElement(i.Fragment,null,i.createElement(f.PureSelectControl,{title:"[Instance] 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i.createElement(o.PluginReactContext.Provider,{value:this.props.plugin},i.createElement(ie,null))},t}(i.Component),ne=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return Object(n.__extends)(t,e),t.prototype.render=function(){return i.createElement(o.PluginReactContext.Provider,{value:this.props.plugin},i.createElement("div",{className:"msp-plugin"},this.props.children))},t}(i.Component),ie=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.onDrop=function(e){var r;if(e.preventDefault(),e.dataTransfer.items){for(var n=0;n<e.dataTransfer.items.length;n++)if("file"===e.dataTransfer.items[n].kind){r=e.dataTransfer.items[n].getAsFile();break}}else r=e.dataTransfer.files[0];if(r){var i=(null==r?void 0:r.name.toLowerCase())||"";(i.endsWith("molx")||i.endsWith("molj"))&&c.PluginCommands.State.Snapshots.OpenFile(t.plugin,{file:r})}},t.onDragOver=function(e){e.preventDefault()},t}return 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/**
@license
Copyright (c) 2019 The Polymer Project Authors. All rights reserved.
This code may only be used under the BSD style license found at
http://polymer.github.io/LICENSE.txt The complete set of authors may be found at
http://polymer.github.io/AUTHORS.txt The complete set of contributors may be
found at http://polymer.github.io/CONTRIBUTORS.txt Code distributed by Google as
part of the polymer project is also subject to an additional IP rights grant
found at http://polymer.github.io/PATENTS.txt
*/
const K=window.ShadowRoot&&(void 0===window.ShadyCSS||window.ShadyCSS.nativeShadow)&&"adoptedStyleSheets"in Document.prototype&&"replace"in CSSStyleSheet.prototype,Q=Symbol();class X{constructor(t,e){if(e!==Q)throw new Error("CSSResult is not constructable. Use `unsafeCSS` or `css` instead.");this.cssText=t}get styleSheet(){return void 0===this._styleSheet&&(K?(this._styleSheet=new CSSStyleSheet,this._styleSheet.replaceSync(this.cssText)):this._styleSheet=null),this._styleSheet}toString(){return this.cssText}}
/**
 * @license
 * Copyright (c) 2017 The Polymer Project Authors. All rights reserved.
 * This code may only be used under the BSD style license found at
 * http://polymer.github.io/LICENSE.txt
 * The complete set of authors may be found at
 * http://polymer.github.io/AUTHORS.txt
 * The complete set of contributors may be found at
 * http://polymer.github.io/CONTRIBUTORS.txt
 * Code distributed by Google as part of the polymer project is also
 * subject to an additional IP rights grant found at
 * http://polymer.github.io/PATENTS.txt
 */
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t=["customDataUrl","customDataFormat","ligandLabelCompId","bgColorR","bgColorG","bgColorB","ligandAuthAsymId","ligandAuthSeqId","ligandHydrogens","highlightColorR","highlightColorG","highlightColorB","selectColorR","selectColorG","selectColorB","hidePolymer","hideWater","hideHet","hideCarbs","hideNonStandard","hideCoarse","hideExpandIcon","hideSelectionIcon","hideAnimationIcon"],e=this.constructor.properties;if(e)for(let i in e)this[i]&&(this.initParams||(this.initParams=Object.assign({},{})),-1==t.indexOf(i)?this.initParams[i]=this[i]:this.formatParam(i))}connectedCallback(){super.connectedCallback(),this.createParamModel(),this.viewerInstance=new PDBeMolstarPlugin,this.validateParams()&&this.initParams&&this.viewerInstance.render(this,this.initParams)}createRenderRoot(){return this}}e.default=tt;customElements.define("pdbe-molstar",tt)}]);
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