KarrLab/wc_rules

{
    "binding": {
        "ligand_receptor": {
            "monomer": {
                "association_constant": 1.3e-07,
                "dissociation_constant": 0.0
            },
            "dimer": {
                "association_constant": 0.25,
                "dissociation_constant": 0.0
            }
        },
        "lyn_receptor": {
            "constitutive": {
                "association_constant": 0.05,
                "dissociation_constant": 20.0
            },
            "active": {
                "association_constant": 0.05,
                "dissociation_constant": 0.12
            }
        },
        "syk_receptor": {
            "association_constant": 0.06,
            "dissociation_constant": 20.0
        }
    },
    "transphosphorylation": {
        "lyn_kinase": {
            "constitutive": {
                "beta": {
                    "phosphorylation_rate": 30
                },
                "gamma": {
                    "phosphorylation_rate": 1
                },
                "linker": {
                    "phosphorylation_rate": 30
                }
            },
            "active": {
                "beta": {
                    "phosphorylation_rate": 100
                },
                "gamma": {
                    "phosphorylation_rate": 3
                },
                "linker": {
                    "phosphorylation_rate": 100
                }
            }
        },
        "syk_kinase": {
            "aloop_unphosphorylated": {
                "phosphorylation_rate": 100
            },
            "aloop_phosphorylated": {
                "phosphorylation_rate": 200
            }
        }
    },
    "dephosphorylation": {
        "receptor": {
            "dephosphorylation_rate": 20.0
        },
        "membrane_syk": {
            "dephosphorylation_rate": 20.0
        },
        "free_syk": {
            "dephosphorylation_rate": 20.0
        }
    }
}