KarrLab/wc_rules

binding:
  ligand_receptor:
    dimer:
      association_constant: 0.25
      dissociation_constant: 0.0
    monomer:
      association_constant: 1.3e-07
      dissociation_constant: 0.0
  lyn_receptor:
    active:
      association_constant: 0.05
      dissociation_constant: 0.12
    constitutive:
      association_constant: 0.05
      dissociation_constant: 20.0
  syk_receptor:
    association_constant: 0.06
    dissociation_constant: 20.0
dephosphorylation:
  free_syk:
    dephosphorylation_rate: 20.0
  membrane_syk:
    dephosphorylation_rate: 20.0
  receptor:
    dephosphorylation_rate: 20.0
transphosphorylation:
  lyn_kinase:
    active:
      beta:
        phosphorylation_rate: 100
      gamma:
        phosphorylation_rate: 3
      linker:
        phosphorylation_rate: 100
    constitutive:
      beta:
        phosphorylation_rate: 30
      gamma:
        phosphorylation_rate: 1
      linker:
        phosphorylation_rate: 30
  syk_kinase:
    aloop_phosphorylated:
      phosphorylation_rate: 200
    aloop_unphosphorylated:
      phosphorylation_rate: 100